SERPINB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)8.11258450
2regulation of integrin activation (GO:0033623)6.79597291
3positive regulation of actin filament depolymerization (GO:0030836)6.48445495
4regulation of vitamin metabolic process (GO:0030656)6.44252427
5response to peptidoglycan (GO:0032494)6.42340232
6detection of bacterium (GO:0016045)6.31583692
7detection of other organism (GO:0098543)6.07496874
8regulation of heat generation (GO:0031650)5.51413200
9regulation of podosome assembly (GO:0071801)5.31574514
10thrombin receptor signaling pathway (GO:0070493)5.21401276
11regulation of chronic inflammatory response (GO:0002676)5.15530334
12detection of external biotic stimulus (GO:0098581)5.14940309
13regulation of cytokine secretion involved in immune response (GO:0002739)5.06235539
14regulation of membrane protein ectodomain proteolysis (GO:0051043)5.01799035
15positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.96928525
16bundle of His cell to Purkinje myocyte communication (GO:0086069)4.94556446
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.77151685
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.77151685
19modulation by symbiont of host immune response (GO:0052553)4.77151685
20positive regulation by symbiont of host defense response (GO:0052509)4.77151685
21modulation by symbiont of host defense response (GO:0052031)4.77151685
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.77151685
23cellular extravasation (GO:0045123)4.56806562
24G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.48971642
25regulation of heterotypic cell-cell adhesion (GO:0034114)4.47977741
26detection of biotic stimulus (GO:0009595)4.47718223
27negative regulation of amino acid transport (GO:0051956)4.45885832
28desmosome organization (GO:0002934)4.42438092
29monocyte chemotaxis (GO:0002548)4.26821362
30detection of molecule of bacterial origin (GO:0032490)4.23917936
31negative regulation by host of viral transcription (GO:0043922)4.08387663
32cellular response to nicotine (GO:0071316)4.05849765
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.98751391
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.98497382
35linoleic acid metabolic process (GO:0043651)3.97539877
36chronic inflammatory response (GO:0002544)3.94823246
37cytokine secretion (GO:0050663)3.93725732
38regulation of lymphocyte chemotaxis (GO:1901623)3.92441620
39regulation of nitric oxide biosynthetic process (GO:0045428)3.90718337
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.85887793
41hydrogen peroxide biosynthetic process (GO:0050665)3.82754526
42regulation of inositol phosphate biosynthetic process (GO:0010919)3.80089800
43branching involved in labyrinthine layer morphogenesis (GO:0060670)3.75973057
44protein kinase C signaling (GO:0070528)3.73420599
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.71620074
46regulation of immunoglobulin secretion (GO:0051023)3.68266143
47positive regulation of hemostasis (GO:1900048)3.67469607
48positive regulation of blood coagulation (GO:0030194)3.67469607
49positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.64550585
50negative regulation of lipid storage (GO:0010888)3.64116621
51lipoxygenase pathway (GO:0019372)3.63465794
52negative regulation of cytokine production involved in immune response (GO:0002719)3.61271589
53positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.60988651
54positive regulation of acute inflammatory response (GO:0002675)3.58234492
55negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.56625320
56cellular response to lipopolysaccharide (GO:0071222)3.56579944
57regulation of interferon-alpha production (GO:0032647)3.52569710
58regulation of NF-kappaB import into nucleus (GO:0042345)3.51372636
59positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.50678742
60negative regulation of nitric oxide biosynthetic process (GO:0045019)3.49089511
61positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.46867493
62cellular copper ion homeostasis (GO:0006878)3.46355756
63neutrophil chemotaxis (GO:0030593)3.43714310
64G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.43584632
65cellular response to molecule of bacterial origin (GO:0071219)3.40999554
66NIK/NF-kappaB signaling (GO:0038061)3.40147723
67positive regulation of lymphocyte migration (GO:2000403)3.40145366
68regulation of vascular endothelial growth factor production (GO:0010574)3.39644768
69regulation of fever generation (GO:0031620)3.39387802
70germinal center formation (GO:0002467)3.36204699
71negative regulation of interleukin-12 production (GO:0032695)3.36052477
72reactive oxygen species biosynthetic process (GO:1903409)3.36001515
73positive regulation of coagulation (GO:0050820)3.34474564
74positive regulation of chemokine biosynthetic process (GO:0045080)3.34466500
75superoxide anion generation (GO:0042554)3.34445625
76neutrophil migration (GO:1990266)3.34139133
77response to protozoan (GO:0001562)3.33197592
78activation of MAPKKK activity (GO:0000185)3.31645228
79positive regulation of heat generation (GO:0031652)3.27885916
80neutrophil activation involved in immune response (GO:0002283)3.26987765
81positive regulation of mast cell activation involved in immune response (GO:0033008)3.23250585
82positive regulation of mast cell degranulation (GO:0043306)3.23250585
83regulation of interleukin-8 biosynthetic process (GO:0045414)3.22613163
84negative regulation of interleukin-17 production (GO:0032700)3.22431415
85regulation of prostaglandin secretion (GO:0032306)3.19235377
86positive regulation of macrophage cytokine production (GO:0060907)3.19084214
87negative regulation of organic acid transport (GO:0032891)3.17758383
88inflammatory response to antigenic stimulus (GO:0002437)3.17141804
89regulation of T-helper 2 cell differentiation (GO:0045628)3.16640350
90macrophage activation involved in immune response (GO:0002281)3.15430555
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14561739
92positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.14129132
93regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.09964917
94heart valve formation (GO:0003188)3.09778605
95positive regulation of prostaglandin secretion (GO:0032308)3.09614344
96cellular response to type I interferon (GO:0071357)3.09474281
97type I interferon signaling pathway (GO:0060337)3.09474281
98modulation of growth of symbiont involved in interaction with host (GO:0044144)3.08552947
99regulation of growth of symbiont in host (GO:0044126)3.08552947
100negative regulation of growth of symbiont in host (GO:0044130)3.08552947
101negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.08552947
102positive regulation of transcription factor import into nucleus (GO:0042993)3.08519430
103regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.07096946
104T-helper 1 type immune response (GO:0042088)3.05920602
105positive regulation of type 2 immune response (GO:0002830)3.05666640
106regulation of interleukin-2 biosynthetic process (GO:0045076)3.05588655
107positive regulation of chemokine production (GO:0032722)3.05308063
108low-density lipoprotein particle clearance (GO:0034383)3.05065008
109response to type I interferon (GO:0034340)3.04967158
110gap junction assembly (GO:0016264)3.03865345
111regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.02581628
112negative regulation of membrane potential (GO:0045837)3.00466545
113granulocyte chemotaxis (GO:0071621)2.99619029
114regulation of T-helper 1 cell differentiation (GO:0045625)2.98722883
115production of molecular mediator involved in inflammatory response (GO:0002532)2.98692609
116granulocyte activation (GO:0036230)2.98182101
117response to muramyl dipeptide (GO:0032495)2.98139936
118eosinophil chemotaxis (GO:0048245)2.98099432
119glycosphingolipid catabolic process (GO:0046479)2.96419775
120negative regulation of T cell mediated immunity (GO:0002710)2.95947724
121cellular response to biotic stimulus (GO:0071216)2.95711879
122regulation of interleukin-6 production (GO:0032675)2.94518382
123positive regulation vascular endothelial growth factor production (GO:0010575)2.93917837
124regulation of lymphocyte migration (GO:2000401)2.92895206
125negative regulation of alcohol biosynthetic process (GO:1902931)2.91906532
126positive regulation of NF-kappaB import into nucleus (GO:0042346)2.91665120
127positive regulation of interleukin-10 production (GO:0032733)2.91490903
128defense response to protozoan (GO:0042832)2.90766766
129oligosaccharide catabolic process (GO:0009313)2.90446505
130negative regulation of production of molecular mediator of immune response (GO:0002701)2.89703154
131positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.87408036
132neutrophil mediated immunity (GO:0002446)2.86962271
133regulation of mast cell degranulation (GO:0043304)2.86085389
134granulocyte migration (GO:0097530)2.85419463
135myeloid dendritic cell differentiation (GO:0043011)2.83190711
136negative regulation of glucose transport (GO:0010829)2.82387903
137positive regulation of mast cell activation (GO:0033005)2.82117303
138positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.81328517
139xenobiotic catabolic process (GO:0042178)2.80594865
140purinergic nucleotide receptor signaling pathway (GO:0035590)2.80102771
141leukocyte aggregation (GO:0070486)2.79904770
142positive regulation of steroid biosynthetic process (GO:0010893)2.79143239
143adhesion of symbiont to host cell (GO:0044650)2.78824836
144virion attachment to host cell (GO:0019062)2.78824836
145positive regulation of interleukin-6 production (GO:0032755)2.78609734
146response to ATP (GO:0033198)2.78361683
147negative regulation of myeloid cell apoptotic process (GO:0033033)2.78053959
148respiratory burst (GO:0045730)2.76049467
149long-chain fatty acid biosynthetic process (GO:0042759)2.75600548
150positive regulation of interferon-alpha production (GO:0032727)2.74567370
151regulation of mononuclear cell migration (GO:0071675)2.73258146
152regulation of interleukin-12 biosynthetic process (GO:0045075)2.72747306
153regulation of interleukin-12 production (GO:0032655)2.72638256
154positive regulation of cytokine secretion (GO:0050715)2.72221042
155positive regulation of T-helper cell differentiation (GO:0045624)2.71915988
156microglial cell activation (GO:0001774)2.71672673
157regulation of chemokine biosynthetic process (GO:0045073)2.71372962
158interferon-gamma-mediated signaling pathway (GO:0060333)2.70512248
159nitric oxide mediated signal transduction (GO:0007263)2.69745547
160cortical actin cytoskeleton organization (GO:0030866)2.69145616
161ovulation (GO:0030728)2.68739162
162response to manganese ion (GO:0010042)2.68513151
163regulation of B cell differentiation (GO:0045577)2.67735381
164regulation of water loss via skin (GO:0033561)2.64228758
165regulation of gonadotropin secretion (GO:0032276)2.64032430
166positive regulation of nitric oxide biosynthetic process (GO:0045429)2.63429633
167regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63423974
168cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.63137634
169response to host immune response (GO:0052572)2.62700755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.84548102
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.29585854
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.27644839
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24771127
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.67883315
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57547329
7* IRF8_27001747_Chip-Seq_BMDM_Mouse2.52005830
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.41050574
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32998379
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32449678
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32079628
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16416193
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.08761094
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.04632504
15BP1_19119308_ChIP-ChIP_Hs578T_Human11.3201986
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95799331
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83378514
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79486634
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77484026
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74164628
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69490952
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63479582
23VDR_24787735_ChIP-Seq_THP-1_Human1.62654901
24GATA1_22025678_ChIP-Seq_K562_Human1.60853877
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55799641
26SPI1_23547873_ChIP-Seq_NB4_Human1.48151494
27* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48099356
28VDR_21846776_ChIP-Seq_THP-1_Human1.44478549
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41616552
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.40254527
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38583679
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.36359968
33SOX2_20726797_ChIP-Seq_SW620_Human1.34500027
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33793223
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32710159
36* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30563121
37SCL_19346495_ChIP-Seq_HPC-7_Human1.29313292
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29027903
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28600964
40RUNX_20019798_ChIP-Seq_JUKART_Human1.25054183
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25028637
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24857190
43* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23100497
44* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23100497
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21668089
46RXR_22108803_ChIP-Seq_LS180_Human1.20068922
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.19480521
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19324361
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.19315003
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19059312
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17174937
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17085805
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16016316
54* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15279117
55MAF_26560356_Chip-Seq_TH1_Human1.14912249
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.13762804
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.11297253
58GATA1_19941826_ChIP-Seq_K562_Human1.10099717
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.09134310
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08735974
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08735974
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08735974
63MYB_26560356_Chip-Seq_TH2_Human1.08058807
64TCF7_22412390_ChIP-Seq_EML_Mouse1.07808602
65* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07231836
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03097047
67TFEB_21752829_ChIP-Seq_HELA_Human1.02520205
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02235935
69CJUN_26792858_Chip-Seq_BT549_Human1.02058226
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.00896948
71CLOCK_20551151_ChIP-Seq_293T_Human0.98368543
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97073740
73* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96462021
74EGR1_19374776_ChIP-ChIP_THP-1_Human0.95553155
75* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95552266
76* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95382050
77KDM2B_26808549_Chip-Seq_DND41_Human0.95217234
78* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94613285
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94051990
80GBX2_23144817_ChIP-Seq_PC3_Human0.93558188
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93433640
82* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93195035
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93138548
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.92500722
85VDR_24763502_ChIP-Seq_THP-1_Human0.92369868
86LXR_22292898_ChIP-Seq_THP-1_Human0.91788697
87* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91006705
88TP63_23658742_ChIP-Seq_EP156T_Human0.90992718
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90460145
90TCF4_18268006_ChIP-ChIP_LS174T_Human0.89700141
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89461202
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87498906
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87498906
94* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85023339
95EGR1_19032775_ChIP-ChIP_M12_Human0.84958937
96* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84852716
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84774874
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84477810
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83930357
100* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82611036
101KDM2B_26808549_Chip-Seq_K562_Human0.82461727
102LXR_22158963_ChIP-Seq_LIVER_Mouse0.82320541
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.82270664
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82227521
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81040219
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80482500
107EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80366269
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80138678
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79276621
110UTX_26944678_Chip-Seq_JUKART_Human0.79275892
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78838272
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78815253
113MYB_26560356_Chip-Seq_TH1_Human0.77935309
114* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77646622
115RXR_22158963_ChIP-Seq_LIVER_Mouse0.77515333
116TP53_18474530_ChIP-ChIP_U2OS_Human0.76405757
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74802575
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74484091
119* PU_27001747_Chip-Seq_BMDM_Mouse0.73607249
120VDR_22108803_ChIP-Seq_LS180_Human0.73253825
121* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72564474
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71987446
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.71203079
124* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70011522
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.68112223
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.67917406
127TP53_16413492_ChIP-PET_HCT116_Human0.66999048
128GATA2_19941826_ChIP-Seq_K562_Human0.66753460
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.66395684
130GATA3_26560356_Chip-Seq_TH2_Human0.64827996
131SUZ12_27294783_Chip-Seq_ESCs_Mouse0.64773528
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.64228190
133ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64093487
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.64001353
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.63412343
136SPI1_23127762_ChIP-Seq_K562_Human0.63367938
137* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.63194551
138AR_21572438_ChIP-Seq_LNCaP_Human0.62762937
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.62627683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.25596651
2MP0009785_altered_susceptibility_to4.19183457
3MP0003436_decreased_susceptibility_to3.57153545
4MP0002148_abnormal_hypersensitivity_rea3.47297217
5MP0002419_abnormal_innate_immunity3.07051765
6MP0009840_abnormal_foam_cell2.95434714
7MP0010352_gastrointestinal_tract_polyps2.79244731
8MP0005025_abnormal_response_to2.73109183
9MP0005000_abnormal_immune_tolerance2.73046465
10MP0004947_skin_inflammation2.69937054
11MP0003453_abnormal_keratinocyte_physiol2.68569740
12MP0003828_pulmonary_edema2.55996485
13MP0003300_gastrointestinal_ulcer2.53398839
14MP0002139_abnormal_hepatobiliary_system2.53083802
15MP0005058_abnormal_lysosome_morphology2.45736830
16MP0003191_abnormal_cellular_cholesterol2.41446802
17MP0002254_reproductive_system_inflammat2.35995747
18MP0005464_abnormal_platelet_physiology2.34951420
19MP0009764_decreased_sensitivity_to2.33288253
20MP0006082_CNS_inflammation2.31678258
21MP0002796_impaired_skin_barrier2.27789673
22MP0008004_abnormal_stomach_pH2.26136485
23MP0000383_abnormal_hair_follicle2.18065648
24MP0001533_abnormal_skeleton_physiology2.13601254
25MP0005451_abnormal_body_composition2.10178062
26MP0003075_altered_response_to2.02415620
27MP0001790_abnormal_immune_system1.95860985
28MP0005387_immune_system_phenotype1.95860985
29MP0001835_abnormal_antigen_presentation1.95383875
30MP0005275_abnormal_skin_tensile1.95251810
31MP0003303_peritoneal_inflammation1.94353159
32MP0002452_abnormal_antigen_presenting1.93701711
33MP0002723_abnormal_immune_serum1.92068971
34MP0006054_spinal_hemorrhage1.89155659
35MP0001800_abnormal_humoral_immune1.84242371
36MP0002933_joint_inflammation1.83845988
37MP0002098_abnormal_vibrissa_morphology1.76738713
38MP0002006_tumorigenesis1.75206521
39MP0001845_abnormal_inflammatory_respons1.68344835
40MP0000343_altered_response_to1.66699007
41MP0002420_abnormal_adaptive_immunity1.63023284
42MP0001819_abnormal_immune_cell1.62354040
43MP0010678_abnormal_skin_adnexa1.61718863
44MP0003172_abnormal_lysosome_physiology1.60966364
45MP0001216_abnormal_epidermal_layer1.58661985
46MP0003941_abnormal_skin_development1.57381099
47MP0002060_abnormal_skin_morphology1.56852497
48MP0005165_increased_susceptibility_to1.55756300
49MP0003656_abnormal_erythrocyte_physiolo1.55079713
50MP0000604_amyloidosis1.51575019
51MP0001545_abnormal_hematopoietic_system1.49755441
52MP0005397_hematopoietic_system_phenotyp1.49755441
53MP0002405_respiratory_system_inflammati1.45593636
54MP0003195_calcinosis1.45242780
55MP0001853_heart_inflammation1.37920428
56MP0010771_integument_phenotype1.36881563
57MP0003566_abnormal_cell_adhesion1.35184705
58MP0000566_synostosis1.34962178
59MP0005167_abnormal_blood-brain_barrier1.34326997
60MP0000579_abnormal_nail_morphology1.34017961
61MP0005623_abnormal_meninges_morphology1.32730245
62MP0008469_abnormal_protein_level1.30778331
63MP0004381_abnormal_hair_follicle1.27239635
64MP0005390_skeleton_phenotype1.25592672
65MP0010155_abnormal_intestine_physiology1.23842848
66MP0002295_abnormal_pulmonary_circulatio1.21968513
67MP0005166_decreased_susceptibility_to1.21384907
68MP0005171_absent_coat_pigmentation1.17805543
69MP0003448_altered_tumor_morphology1.16784257
70MP0002998_abnormal_bone_remodeling1.14265596
71MP0001501_abnormal_sleep_pattern1.12557234
72MP0001191_abnormal_skin_condition1.10656775
73MP0010234_abnormal_vibrissa_follicle1.10414084
74MP0005310_abnormal_salivary_gland1.09997724
75MP0003806_abnormal_nucleotide_metabolis1.07125139
76MP0005023_abnormal_wound_healing1.06166045
77MP0005501_abnormal_skin_physiology1.05784381
78MP0003705_abnormal_hypodermis_morpholog1.03513430
79MP0001243_abnormal_dermal_layer1.00772864
80MP0003880_abnormal_central_pattern0.99928710
81MP0000685_abnormal_immune_system0.99639176
82MP0001542_abnormal_bone_strength0.98664933
83MP0000920_abnormal_myelination0.95974349
84MP0005164_abnormal_response_to0.95372275
85MP0003091_abnormal_cell_migration0.94826653
86MP0009697_abnormal_copulation0.94685926
87MP0009765_abnormal_xenobiotic_induced0.94655660
88MP0005085_abnormal_gallbladder_physiolo0.93100335
89MP0009333_abnormal_splenocyte_physiolog0.91940655
90MP0004782_abnormal_surfactant_physiolog0.89155941
91MP0003186_abnormal_redox_activity0.85531681
92MP0009763_increased_sensitivity_to0.83226000
93MP0002277_abnormal_respiratory_mucosa0.83042692
94MP0002877_abnormal_melanocyte_morpholog0.82775726
95MP0004510_myositis0.82529052
96MP0005647_abnormal_sex_gland0.82224800
97MP0003950_abnormal_plasma_membrane0.80143661
98MP0000858_altered_metastatic_potential0.80088824
99MP0009278_abnormal_bone_marrow0.78925402
100MP0003690_abnormal_glial_cell0.78136906
101MP0005535_abnormal_body_temperature0.76497076
102MP0005671_abnormal_response_to0.76400122
103MP0000367_abnormal_coat/_hair0.75712080
104MP0001663_abnormal_digestive_system0.75668918
105MP0008438_abnormal_cutaneous_collagen0.75357611
106* MP0000716_abnormal_immune_system0.74738780
107MP0003646_muscle_fatigue0.72955945
108MP0002332_abnormal_exercise_endurance0.72590670
109MP0000249_abnormal_blood_vessel0.72566374
110MP0005076_abnormal_cell_differentiation0.71534605
111MP0008874_decreased_physiological_sensi0.71059699
112MP0005257_abnormal_intraocular_pressure0.70870830
113MP0009931_abnormal_skin_appearance0.70779835
114* MP0002398_abnormal_bone_marrow0.70706045
115MP0004808_abnormal_hematopoietic_stem0.70366192
116MP0004883_abnormal_blood_vessel0.70345563
117MP0002133_abnormal_respiratory_system0.69170875
118MP0005388_respiratory_system_phenotype0.69170875
119MP0001851_eye_inflammation0.69081935
120MP0002736_abnormal_nociception_after0.68627115
121* MP0002429_abnormal_blood_cell0.68239146
122MP0003252_abnormal_bile_duct0.68009495
123MP0000467_abnormal_esophagus_morphology0.67525601
124MP0000371_diluted_coat_color0.65498302
125MP0001346_abnormal_lacrimal_gland0.65277452
126MP0002722_abnormal_immune_system0.64931529
127MP0003795_abnormal_bone_structure0.63601044
128MP0001727_abnormal_embryo_implantation0.63581988
129MP0003329_amyloid_beta_deposits0.61016258
130MP0005595_abnormal_vascular_smooth0.59442213
131MP0000689_abnormal_spleen_morphology0.58734325
132MP0005266_abnormal_metabolism0.58032344
133MP0002138_abnormal_hepatobiliary_system0.57694637
134MP0010307_abnormal_tumor_latency0.53568071
135MP0000750_abnormal_muscle_regeneration0.53343933
136MP0003045_fibrosis0.52584727

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)8.31701949
2Recurrent abscess formation (HP:0002722)7.68714147
3Abnormality of liposaccharide metabolism (HP:0010968)7.09011548
4Abnormality of glycosphingolipid metabolism (HP:0004343)7.09011548
5Abnormality of glycolipid metabolism (HP:0010969)7.09011548
6Increased neuronal autofluorescent lipopigment (HP:0002074)6.74788684
7Interstitial pulmonary disease (HP:0006530)6.32058868
8Increased cerebral lipofuscin (HP:0011813)6.20653948
9Recurrent bacterial skin infections (HP:0005406)5.64897962
10Eczematoid dermatitis (HP:0000976)5.60157499
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)5.27474959
12Recurrent gram-negative bacterial infections (HP:0005420)5.10648632
13Systemic lupus erythematosus (HP:0002725)5.07205313
14Loss of speech (HP:0002371)4.54201530
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.51353411
16Dysostosis multiplex (HP:0000943)4.45073320
17Thick nail (HP:0001805)4.37213737
18Mediastinal lymphadenopathy (HP:0100721)4.31001979
19Neurofibrillary tangles (HP:0002185)3.89857904
20Nuclear cataract (HP:0100018)3.85301875
21Gingivitis (HP:0000230)3.80690223
22Pustule (HP:0200039)3.79352851
23Mutism (HP:0002300)3.77290948
24Autoimmune thrombocytopenia (HP:0001973)3.60713352
25Keratoconjunctivitis sicca (HP:0001097)3.54590310
26Fused cervical vertebrae (HP:0002949)3.50080699
27Apathy (HP:0000741)3.38523288
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.30910205
29Abnormality of polysaccharide metabolism (HP:0011012)3.30910205
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.30910205
31Congenital ichthyosiform erythroderma (HP:0007431)3.30525929
32Abnormality of macrophages (HP:0004311)3.27810152
33Diminished motivation (HP:0000745)3.25213989
34Keratoconjunctivitis (HP:0001096)3.21323985
35Nausea (HP:0002018)3.14662687
36Parakeratosis (HP:0001036)3.11832899
37Mucopolysacchariduria (HP:0008155)3.11807917
38Urinary glycosaminoglycan excretion (HP:0003541)3.11807917
39Vacuolated lymphocytes (HP:0001922)2.98422191
40Recurrent skin infections (HP:0001581)2.94408316
41Plantar hyperkeratosis (HP:0007556)2.93476796
42Right ventricular cardiomyopathy (HP:0011663)2.88755324
43Obstructive lung disease (HP:0006536)2.87411123
44Chronic obstructive pulmonary disease (HP:0006510)2.87411123
45Elevated erythrocyte sedimentation rate (HP:0003565)2.82036953
46Spinal muscular atrophy (HP:0007269)2.80637171
47Cerebral inclusion bodies (HP:0100314)2.80035625
48Increased serum ferritin (HP:0003281)2.77527524
49Amyloidosis (HP:0011034)2.70488748
50Periodontitis (HP:0000704)2.69803493
51Increased IgE level (HP:0003212)2.68654004
52Petechiae (HP:0000967)2.66667473
53Axonal loss (HP:0003447)2.66081792
54Glomerulonephritis (HP:0000099)2.63959569
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.62815862
56Palmoplantar hyperkeratosis (HP:0000972)2.62339111
57Polyneuropathy (HP:0001271)2.57816083
58Purpura (HP:0000979)2.57490392
59Neuronal loss in central nervous system (HP:0002529)2.57446741
60Palmar hyperkeratosis (HP:0010765)2.54794795
61Premature loss of primary teeth (HP:0006323)2.53175125
62Atrioventricular block (HP:0001678)2.52845137
63Joint swelling (HP:0001386)2.51631466
64Cellulitis (HP:0100658)2.50643984
65Inappropriate behavior (HP:0000719)2.47447183
66Recurrent fungal infections (HP:0002841)2.46296283
67Vasculitis (HP:0002633)2.44112536
68Colitis (HP:0002583)2.44024810
69Progressive neurologic deterioration (HP:0002344)2.43137997
70Retrobulbar optic neuritis (HP:0100654)2.40171007
71Optic neuritis (HP:0100653)2.40171007
72Orchitis (HP:0100796)2.37613250
73Corneal erosion (HP:0200020)2.34331640
74Milia (HP:0001056)2.33022811
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.32874734
76Myositis (HP:0100614)2.31907149
77Sepsis (HP:0100806)2.31804020
78Metaphyseal irregularity (HP:0003025)2.29624012
79Disinhibition (HP:0000734)2.29135422
80Urticaria (HP:0001025)2.24681306
81Bone pain (HP:0002653)2.23886232
82Woolly hair (HP:0002224)2.23591091
83Hypotrichosis (HP:0001006)2.22882547
84Gangrene (HP:0100758)2.21143720
85Pruritus (HP:0000989)2.20345038
86Lip pit (HP:0100267)2.18835963
87Sex reversal (HP:0012245)2.18679380
88Abnormal sex determination (HP:0012244)2.18679380
89Autoimmune hemolytic anemia (HP:0001890)2.17338421
90Prolonged neonatal jaundice (HP:0006579)2.15410773
91Abnormality of the pericardium (HP:0001697)2.15224704
92Tetraparesis (HP:0002273)2.14278621
93Erythroderma (HP:0001019)2.13569042
94Nephritis (HP:0000123)2.11190467
95Progressive visual loss (HP:0000529)2.09376329
96Arterial thrombosis (HP:0004420)2.08473139
97Asymmetric septal hypertrophy (HP:0001670)2.08441009
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.08004085
99Osteolytic defects of the hand bones (HP:0009699)2.08004085
100IgM deficiency (HP:0002850)2.07614264
101Increased IgM level (HP:0003496)2.06571523
102Abnormality of iron homeostasis (HP:0011031)2.05949652
103Erythema (HP:0010783)2.05898939
104Hemoptysis (HP:0002105)2.05290881
105Recurrent viral infections (HP:0004429)2.04791341
106Abnormality of complement system (HP:0005339)2.03741485
107Supranuclear gaze palsy (HP:0000605)2.03184545
108Episodic fever (HP:0001954)2.02949088
109Peritonitis (HP:0002586)2.01719763
110Hypohidrosis (HP:0000966)2.00877056
111Vertigo (HP:0002321)1.99578991
112Pulmonary infiltrates (HP:0002113)1.99229183
113Osteomyelitis (HP:0002754)1.99081293
114Clumsiness (HP:0002312)1.98311000
115Myocardial infarction (HP:0001658)1.97207963
116Submucous cleft hard palate (HP:0000176)1.90818208
117Vertebral compression fractures (HP:0002953)1.89821311
118Prolonged partial thromboplastin time (HP:0003645)1.89160915
119Personality changes (HP:0000751)1.89070524
120Dementia (HP:0000726)1.88704561
121Spontaneous hematomas (HP:0007420)1.88499133
122Leukocytosis (HP:0001974)1.88131748
123Basal ganglia calcification (HP:0002135)1.86746668
124Abnormality of the pleura (HP:0002103)1.86582501
125T lymphocytopenia (HP:0005403)1.86056955
126Malnutrition (HP:0004395)1.85475498
127Alopecia of scalp (HP:0002293)1.85268387
128Hypergammaglobulinemia (HP:0010702)1.85103413
129Onycholysis (HP:0001806)1.83521678
130Anorexia (HP:0002039)1.81759671
131Memory impairment (HP:0002354)1.80760067
132Segmental peripheral demyelination/remyelination (HP:0003481)1.80100422
133Peripheral demyelination (HP:0011096)1.80064726
134Complement deficiency (HP:0004431)1.79927750
135Gingival bleeding (HP:0000225)1.79233108
136Skin ulcer (HP:0200042)1.79194345
137Arthralgia (HP:0002829)1.79062227
138Abnormal atrioventricular conduction (HP:0005150)1.79006296
139Keratitis (HP:0000491)1.78162499
140Natal tooth (HP:0000695)1.76817099
141Hepatosplenomegaly (HP:0001433)1.73352957
142Thin bony cortex (HP:0002753)1.72119489
143Ectropion (HP:0000656)1.71905291
144Arterial tortuosity (HP:0005116)1.71252343
145Increased CSF protein (HP:0002922)1.71037976
146White forelock (HP:0002211)1.70922087
147Meningitis (HP:0001287)1.69873907
148Hematochezia (HP:0002573)1.69857568
149Fragile nails (HP:0001808)1.68916281
150Aplasia cutis congenita (HP:0001057)1.67572788
151Heart block (HP:0012722)1.66657989
152Respiratory distress (HP:0002098)1.66054275
153Chronic otitis media (HP:0000389)1.65447991
154Agnosia (HP:0010524)1.64331126
155Rectal fistula (HP:0100590)1.60322894
156Rectovaginal fistula (HP:0000143)1.60322894
157Polygenic inheritance (HP:0010982)1.60247704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK9.20200676
2IRAK34.24519478
3MAP4K14.05084205
4TXK3.92244561
5TAOK23.14842792
6NME23.10965369
7BMPR1B2.55477796
8ADRBK12.35897581
9RIPK12.08513239
10MST42.06799273
11RIPK42.03843349
12MOS1.92618764
13MAP3K141.90979859
14PRPF4B1.90013253
15STK101.86115465
16MST1R1.85791266
17EPHB11.83176312
18MAP3K111.74689318
19TBK11.67833365
20CDC42BPA1.56424199
21ZAP701.54008152
22TYRO31.41461926
23IKBKB1.40991507
24NEK91.40466699
25LRRK21.37084178
26FGR1.36237224
27MAP2K31.35851184
28IRAK21.35174341
29EPHA31.34855457
30PRKCD1.31801935
31SYK1.25814439
32STK241.25241112
33ERBB31.23908673
34TYK21.23388579
35SIK31.20307940
36GRK71.17524436
37LYN1.17208975
38PDGFRA1.13545022
39FGFR41.10678595
40MAP3K131.09652935
41MAP3K51.08738574
42IKBKE1.08246921
43JAK31.08176808
44JAK11.03562446
45MAP3K121.03155535
46TEC1.02679123
47ACVR1B1.01050332
48PKN11.00428320
49HCK0.99083381
50LATS20.97005708
51TGFBR10.95566263
52TRPM70.94476618
53IRAK40.94379066
54JAK20.91913005
55FER0.91468495
56TGFBR20.90671609
57FES0.86458520
58MAP3K30.84285837
59CSK0.82998181
60DAPK20.81727423
61ERBB40.81507459
62LCK0.81338739
63MAP3K10.80913884
64MATK0.76892723
65ERN10.76798479
66TESK10.74846029
67PBK0.72535454
68ITK0.71788267
69CSF1R0.69167850
70BMPR20.68990085
71ARAF0.68667496
72KIT0.65083259
73EPHA20.64706100
74IRAK10.63810191
75NLK0.63742387
76BTK0.60473817
77FGFR30.59240670
78PIM20.59064353
79EGFR0.58690319
80BMX0.58014410
81CLK10.55835289
82CDK60.54968109
83FYN0.54207551
84CHUK0.53841870
85TAOK30.53641941
86DDR20.53397279
87NTRK30.51844960
88PDGFRB0.50751586
89PIM10.49398640
90EPHB20.47719336
91ABL10.46735186
92EIF2AK20.45564419
93PAK40.45434177
94DYRK30.43892695
95MAP3K90.42422072
96GRK50.42059478
97PLK20.41544676
98MAP2K60.41451147
99ALK0.40993876
100KSR20.39655028
101MELK0.39463245
102ICK0.37797845
103PAK30.37625403
104GSK3A0.37487773
105MAPKAPK30.36248209
106DAPK30.36124265
107PRKCG0.34945981
108PTK60.34249610
109IGF1R0.34243708
110PRKCQ0.34168242
111PIK3CG0.34167110
112RPS6KB20.33388265
113KSR10.31392062
114TAOK10.29689888
115TTN0.29142174
116PRKCA0.27277504
117PRKCE0.26304593
118ADRBK20.26084450
119RPS6KL10.26030975
120RPS6KC10.26030975
121MAPK40.25350659
122PRKD10.25191078
123EPHA40.24320086
124MAP2K10.23929667
125SRC0.23529863
126ABL20.23132987
127INSR0.23116356
128PRKACB0.22819368
129MARK30.21723513
130MAP3K20.21122790
131PRKACG0.19765440
132TESK20.19499029
133ERBB20.19137947
134CDK180.18967839
135CDK140.18709279
136HIPK20.18005749
137RPS6KA60.17893950
138CDK150.17726714
139CDK11A0.13631957
140STK30.12666305
141BRAF0.12256009
142LIMK10.12185473
143CAMKK20.11262324
144MAPK70.11090477
145MAPKAPK20.10419905
146CAMK1D0.08909165
147MAP3K80.08846473
148PDK10.08738634

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.73573422
2Graft-versus-host disease_Homo sapiens_hsa053323.64806118
3Legionellosis_Homo sapiens_hsa051343.20536709
4Leishmaniasis_Homo sapiens_hsa051402.93111272
5Rheumatoid arthritis_Homo sapiens_hsa053232.69719930
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.44692768
7Salmonella infection_Homo sapiens_hsa051322.32048591
8Type I diabetes mellitus_Homo sapiens_hsa049402.29421711
9Tuberculosis_Homo sapiens_hsa051522.28272241
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.25684801
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24012088
12Amoebiasis_Homo sapiens_hsa051462.21473920
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.07513424
14Malaria_Homo sapiens_hsa051442.05003207
15Pertussis_Homo sapiens_hsa051332.01927802
16Allograft rejection_Homo sapiens_hsa053301.88560323
17Osteoclast differentiation_Homo sapiens_hsa043801.85555798
18Hematopoietic cell lineage_Homo sapiens_hsa046401.84295175
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73855538
20Phagosome_Homo sapiens_hsa041451.66710711
21African trypanosomiasis_Homo sapiens_hsa051431.61897761
22TNF signaling pathway_Homo sapiens_hsa046681.50056696
23* Complement and coagulation cascades_Homo sapiens_hsa046101.48916658
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47294309
25Fatty acid biosynthesis_Homo sapiens_hsa000611.43069731
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37625894
27Lysosome_Homo sapiens_hsa041421.28464663
28Autoimmune thyroid disease_Homo sapiens_hsa053201.22803545
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19217821
30Collecting duct acid secretion_Homo sapiens_hsa049661.17088551
31Sphingolipid metabolism_Homo sapiens_hsa006001.16491908
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07436689
33Arginine biosynthesis_Homo sapiens_hsa002201.07370555
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05768388
35Histidine metabolism_Homo sapiens_hsa003401.05157584
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.04787626
37Measles_Homo sapiens_hsa051621.04314074
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99737041
39Phenylalanine metabolism_Homo sapiens_hsa003600.98951251
40Asthma_Homo sapiens_hsa053100.98046431
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96010304
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95101636
43Toxoplasmosis_Homo sapiens_hsa051450.95079276
44Antigen processing and presentation_Homo sapiens_hsa046120.93990051
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92546227
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.88760455
47B cell receptor signaling pathway_Homo sapiens_hsa046620.84718784
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.83283630
49Acute myeloid leukemia_Homo sapiens_hsa052210.80190974
50Prion diseases_Homo sapiens_hsa050200.79990159
51Prolactin signaling pathway_Homo sapiens_hsa049170.79092211
52Chemokine signaling pathway_Homo sapiens_hsa040620.78395919
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75846880
54Mineral absorption_Homo sapiens_hsa049780.74725133
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71981103
56Type II diabetes mellitus_Homo sapiens_hsa049300.65676471
57Arachidonic acid metabolism_Homo sapiens_hsa005900.63784155
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.63218249
59Epstein-Barr virus infection_Homo sapiens_hsa051690.61885224
60Chemical carcinogenesis_Homo sapiens_hsa052040.60440595
61Other glycan degradation_Homo sapiens_hsa005110.60181109
62Apoptosis_Homo sapiens_hsa042100.60178556
63Influenza A_Homo sapiens_hsa051640.60166076
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60020496
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59464351
66Viral myocarditis_Homo sapiens_hsa054160.59274876
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.56222872
68Vibrio cholerae infection_Homo sapiens_hsa051100.55925538
69Platelet activation_Homo sapiens_hsa046110.55769929
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.51828511
71beta-Alanine metabolism_Homo sapiens_hsa004100.50036353
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49311864
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.48541060
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48085896
75Caffeine metabolism_Homo sapiens_hsa002320.47234695
76VEGF signaling pathway_Homo sapiens_hsa043700.46604769
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45935465
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45259443
79T cell receptor signaling pathway_Homo sapiens_hsa046600.45258836
80Hepatitis B_Homo sapiens_hsa051610.43777670
81Herpes simplex infection_Homo sapiens_hsa051680.43721332
82Sulfur metabolism_Homo sapiens_hsa009200.42861444
83Proteoglycans in cancer_Homo sapiens_hsa052050.42451503
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42380547
85Renin-angiotensin system_Homo sapiens_hsa046140.41379608
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41204683
87Chronic myeloid leukemia_Homo sapiens_hsa052200.39580328
88HIF-1 signaling pathway_Homo sapiens_hsa040660.39479345
89PPAR signaling pathway_Homo sapiens_hsa033200.39069346
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38362593
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.38013511
92Synaptic vesicle cycle_Homo sapiens_hsa047210.37361596
93HTLV-I infection_Homo sapiens_hsa051660.34783283
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.32753352
95MAPK signaling pathway_Homo sapiens_hsa040100.32643961
96Pancreatic cancer_Homo sapiens_hsa052120.32489196
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32316486
98Hepatitis C_Homo sapiens_hsa051600.32065338
99Nitrogen metabolism_Homo sapiens_hsa009100.31207006
100Ether lipid metabolism_Homo sapiens_hsa005650.31055247
101Rap1 signaling pathway_Homo sapiens_hsa040150.30900697
102Dorso-ventral axis formation_Homo sapiens_hsa043200.29926288
103Insulin resistance_Homo sapiens_hsa049310.29160717
104Viral carcinogenesis_Homo sapiens_hsa052030.28038072
105Fatty acid degradation_Homo sapiens_hsa000710.26795332
106Renal cell carcinoma_Homo sapiens_hsa052110.26441918
107ECM-receptor interaction_Homo sapiens_hsa045120.25102909
108Notch signaling pathway_Homo sapiens_hsa043300.24251408
109Serotonergic synapse_Homo sapiens_hsa047260.22430154
110Tyrosine metabolism_Homo sapiens_hsa003500.20988538
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20893607
112Small cell lung cancer_Homo sapiens_hsa052220.19660804
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19602710
114MicroRNAs in cancer_Homo sapiens_hsa052060.19489429
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19441060
116Vitamin digestion and absorption_Homo sapiens_hsa049770.18998509
117Galactose metabolism_Homo sapiens_hsa000520.18644320
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18463654
119Bladder cancer_Homo sapiens_hsa052190.18384137
120Endocytosis_Homo sapiens_hsa041440.18344923
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17804884
122FoxO signaling pathway_Homo sapiens_hsa040680.17309187
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17074043
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.16706515
125GnRH signaling pathway_Homo sapiens_hsa049120.16636913
126Retinol metabolism_Homo sapiens_hsa008300.15975137
127Shigellosis_Homo sapiens_hsa051310.14814033
128Primary immunodeficiency_Homo sapiens_hsa053400.14731670
129Peroxisome_Homo sapiens_hsa041460.14347533
130Fatty acid metabolism_Homo sapiens_hsa012120.12560061
131Linoleic acid metabolism_Homo sapiens_hsa005910.12447214

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