ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratinization (GO:0031424)	9.77415609
2	motile cilium assembly (GO:0044458)	9.64973499
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	9.26560252
4	diterpenoid biosynthetic process (GO:0016102)	9.25357478
5	epithelial cilium movement (GO:0003351)	8.86280364
6	establishment of skin barrier (GO:0061436)	7.89311176
7	desmosome organization (GO:0002934)	7.22191050
8	multicellular organismal water homeostasis (GO:0050891)	7.17062147
9	regulation of water loss via skin (GO:0033561)	6.88810790
10	axoneme assembly (GO:0035082)	6.88462909
11	primary alcohol catabolic process (GO:0034310)	6.85458730
12	terpenoid biosynthetic process (GO:0016114)	6.49978989
13	keratinocyte differentiation (GO:0030216)	6.47616696
14	one-carbon compound transport (GO:0019755)	6.10139270
15	water homeostasis (GO:0030104)	6.00718886
16	ethanol metabolic process (GO:0006067)	5.81128315
17	left/right pattern formation (GO:0060972)	5.66418424
18	retinoic acid metabolic process (GO:0042573)	5.27539220
19	long-chain fatty acid biosynthetic process (GO:0042759)	5.24430161
20	left/right axis specification (GO:0070986)	5.21194097
21	lipoxygenase pathway (GO:0019372)	5.02933742
22	epidermal cell differentiation (GO:0009913)	4.98319753
23	establishment of tissue polarity (GO:0007164)	4.95942715
24	establishment of planar polarity (GO:0001736)	4.95942715
25	ethanol oxidation (GO:0006069)	4.84356299
26	vitamin transmembrane transport (GO:0035461)	4.82994079
27	retinol metabolic process (GO:0042572)	4.73128197
28	peptide cross-linking (GO:0018149)	4.69697431
29	keratinocyte proliferation (GO:0043616)	4.63374730
30	regulation of cilium movement (GO:0003352)	4.47841671
31	epidermis development (GO:0008544)	4.46701316
32	ventricular system development (GO:0021591)	4.42914974
33	microtubule bundle formation (GO:0001578)	4.24910326
34	surfactant homeostasis (GO:0043129)	4.20587921
35	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.15039686
36	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.14748910
37	potassium ion homeostasis (GO:0055075)	4.06306867
38	primary alcohol metabolic process (GO:0034308)	3.97947074
39	intraciliary transport (GO:0042073)	3.94993801
40	intestinal epithelial cell development (GO:0060576)	3.93369827
41	hypotonic response (GO:0006971)	3.88944721
42	gap junction assembly (GO:0016264)	3.81189954
43	hemidesmosome assembly (GO:0031581)	3.80826806
44	response to xenobiotic stimulus (GO:0009410)	3.77996958
45	polyol transport (GO:0015791)	3.64991376
46	cilium organization (GO:0044782)	3.63817826
47	chemical homeostasis within a tissue (GO:0048875)	3.63447666
48	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.63397154
49	lateral sprouting from an epithelium (GO:0060601)	3.58312775
50	lung epithelium development (GO:0060428)	3.54224833
51	O-glycan processing (GO:0016266)	3.52846285
52	cilium assembly (GO:0042384)	3.50943863
53	retinal metabolic process (GO:0042574)	3.45290754
54	glomerular epithelial cell development (GO:0072310)	3.39498942
55	negative regulation of interferon-gamma production (GO:0032689)	3.36661887
56	negative regulation of humoral immune response (GO:0002921)	3.35417317
57	regulation of apoptotic cell clearance (GO:2000425)	3.35312867
58	regulation of interleukin-5 production (GO:0032674)	3.27586274
59	progesterone metabolic process (GO:0042448)	3.26249992
60	detection of bacterium (GO:0016045)	3.26115193
61	sequestering of metal ion (GO:0051238)	3.25061012
62	tolerance induction (GO:0002507)	3.21198673
63	hair cycle (GO:0042633)	3.19841754
64	molting cycle (GO:0042303)	3.19841754
65	positive regulation of tolerance induction (GO:0002645)	3.16249811
66	iron ion import (GO:0097286)	3.14484255
67	sperm capacitation (GO:0048240)	3.11366761
68	establishment of apical/basal cell polarity (GO:0035089)	3.10981366
69	microtubule-based movement (GO:0007018)	3.03417933
70	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.98742981
71	detection of other organism (GO:0098543)	2.96316238
72	centriole assembly (GO:0098534)	2.92781302
73	regulation of interleukin-13 production (GO:0032656)	2.87479960
74	lateral ventricle development (GO:0021670)	2.86485438
75	negative regulation of B cell mediated immunity (GO:0002713)	2.85042706
76	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.85042706
77	cytoplasmic microtubule organization (GO:0031122)	2.84240686
78	cellular component assembly involved in morphogenesis (GO:0010927)	2.83587563
79	negative regulation of T cell differentiation in thymus (GO:0033085)	2.83368133
80	regulation of axon regeneration (GO:0048679)	2.83077601
81	regulation of neuron projection regeneration (GO:0070570)	2.83077601
82	oligosaccharide biosynthetic process (GO:0009312)	2.79019665
83	cell projection assembly (GO:0030031)	2.77211701
84	renal absorption (GO:0070293)	2.77195840
85	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.75818258
86	keratinocyte development (GO:0003334)	2.72933867
87	regulation of germinal center formation (GO:0002634)	2.72335185
88	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.69901517
89	excretion (GO:0007588)	2.68671940
90	skin morphogenesis (GO:0043589)	2.61949862
91	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.61247651
92	copper ion transport (GO:0006825)	2.60990941
93	apical protein localization (GO:0045176)	2.58518377
94	regulation of keratinocyte differentiation (GO:0045616)	2.58172938
95	antimicrobial humoral response (GO:0019730)	2.56719157
96	epithelial cell maturation (GO:0002070)	2.54159241
97	negative regulation of adaptive immune response (GO:0002820)	2.53612947
98	axonemal dynein complex assembly (GO:0070286)	14.8322920
99	cilium or flagellum-dependent cell motility (GO:0001539)	13.0843696
100	cilium movement (GO:0003341)	11.1240864

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	8.49531673
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.87088946
3	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.31551904
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.88181775
5	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.77613972
6	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.70475523
7	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.52625638
8	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.30882762
9	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.25997290
10	TP63_23658742_ChIP-Seq_EP156T_Human	2.21060178
11	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.12697684
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.11576495
13	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.10048578
14	* SOX2_20726797_ChIP-Seq_SW620_Human	2.02539539
15	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.01404387
16	AHR_22903824_ChIP-Seq_MCF-7_Human	2.01201805
17	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.00908660
18	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.00908660
19	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.95219168
20	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.88956326
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.82312592
22	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.81915740
23	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.80274511
24	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.73499423
25	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.73219390
26	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.69859641
27	TP53_18474530_ChIP-ChIP_U2OS_Human	1.66601775
28	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.65954385
29	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.62935800
30	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.59649613
31	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.57157522
32	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.56748888
33	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.52941100
34	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.49735124
35	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.49169486
36	KLF5_25053715_ChIP-Seq_YYC3_Human	1.46095178
37	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.45479957
38	TP53_16413492_ChIP-PET_HCT116_Human	1.39329188
39	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.38879411
40	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.34320278
41	GATA4_25053715_ChIP-Seq_YYC3_Human	1.33444805
42	DROSHA_22980978_ChIP-Seq_HELA_Human	1.31947108
43	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.31465186
44	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.31123456
45	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.24538873
46	* TP63_22573176_ChIP-Seq_HFKS_Human	1.20717859
47	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.19983304
48	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.19983304
49	CJUN_26792858_Chip-Seq_BT549_Human	1.19755572
50	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.18564834
51	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.18243535
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12996401
53	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.12246970
54	RXR_22108803_ChIP-Seq_LS180_Human	1.09373514
55	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.07395600
56	VDR_22108803_ChIP-Seq_LS180_Human	1.07087617
57	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.06439640
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.05562606
59	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.04730314
60	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.00015148
61	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99024469
62	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.98611794
63	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.96988136
64	AR_21572438_ChIP-Seq_LNCaP_Human	0.96728801
65	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.96599715
66	GATA6_25053715_ChIP-Seq_YYC3_Human	0.95986861
67	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95746609
68	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.92329976
69	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.91628846
70	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.90730268
71	SMC4_20622854_ChIP-Seq_HELA_Human	0.89367585
72	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.89051176
73	RBPJ_21746931_ChIP-Seq_IB4_Human	0.88710616
74	SMAD4_21799915_ChIP-Seq_A2780_Human	0.87954768
75	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.87249244
76	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.86443123
77	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.84958671
78	GATA1_19941826_ChIP-Seq_K562_Human	0.84143530
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.83537262
80	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.83330249
81	CEBPB_22108803_ChIP-Seq_LS180_Human	0.82795394
82	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.80114242
83	RACK7_27058665_Chip-Seq_MCF-7_Human	0.79927737
84	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.79700629
85	CDX2_22108803_ChIP-Seq_LS180_Human	0.78800583
86	CLOCK_20551151_ChIP-Seq_293T_Human	0.78190328
87	GATA2_19941826_ChIP-Seq_K562_Human	0.78077171
88	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.77748269
89	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.77069203
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.76986783
91	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.76199852
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.75642894
93	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.75602403
94	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.75602403
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.75417673
96	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.75338388
97	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.71086936
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.71064379
99	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.69826196
100	ELF5_23300383_ChIP-Seq_T47D_Human	0.69425205

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002796_impaired_skin_barrier	6.23208545
2	MP0010234_abnormal_vibrissa_follicle	5.89362918
3	MP0000579_abnormal_nail_morphology	4.56186321
4	MP0005275_abnormal_skin_tensile	4.10192771
5	MP0010678_abnormal_skin_adnexa	3.54909343
6	MP0005501_abnormal_skin_physiology	3.27984374
7	MP0008875_abnormal_xenobiotic_pharmacok	3.11611023
8	MP0003941_abnormal_skin_development	3.07663084
9	MP0000383_abnormal_hair_follicle	3.06698657
10	MP0003453_abnormal_keratinocyte_physiol	3.02176004
11	MP0004043_abnormal_pH_regulation	2.99863292
12	MP0000566_synostosis	2.98873230
13	MP0004264_abnormal_extraembryonic_tissu	2.52515605
14	MP0005377_hearing/vestibular/ear_phenot	2.44373928
15	MP0003878_abnormal_ear_physiology	2.44373928
16	MP0004782_abnormal_surfactant_physiolog	2.41039933
17	MP0001216_abnormal_epidermal_layer	2.40385159
18	MP0000467_abnormal_esophagus_morphology	2.40346445
19	MP0009780_abnormal_chondrocyte_physiolo	2.19656969
20	MP0004885_abnormal_endolymph	2.13833808
21	MP0002653_abnormal_ependyma_morphology	2.13249661
22	MP0002098_abnormal_vibrissa_morphology	2.08734098
23	MP0002060_abnormal_skin_morphology	2.06077219
24	MP0003566_abnormal_cell_adhesion	1.97807917
25	MP0008789_abnormal_olfactory_epithelium	1.90841801
26	MP0000465_gastrointestinal_hemorrhage	1.89318888
27	MP0010771_integument_phenotype	1.85852653
28	MP0005023_abnormal_wound_healing	1.83963424
29	MP0004947_skin_inflammation	1.82673980
30	MP0000762_abnormal_tongue_morphology	1.70167717
31	MP0005409_darkened_coat_color	1.66826167
32	MP0010352_gastrointestinal_tract_polyps	1.63879683
33	MP0001765_abnormal_ion_homeostasis	1.57657359
34	MP0003191_abnormal_cellular_cholesterol	1.57233109
35	MP0002132_abnormal_respiratory_system	1.54245846
36	MP0005248_abnormal_Harderian_gland	1.51188145
37	MP0000678_abnormal_parathyroid_gland	1.49232706
38	MP0000377_abnormal_hair_follicle	1.47622660
39	MP0001984_abnormal_olfaction	1.44425214
40	MP0002277_abnormal_respiratory_mucosa	1.39519461
41	MP0005164_abnormal_response_to	1.32056269
42	MP0004381_abnormal_hair_follicle	1.20573253
43	MP0004019_abnormal_vitamin_homeostasis	1.18401354
44	MP0010155_abnormal_intestine_physiology	1.16155338
45	MP0005623_abnormal_meninges_morphology	1.12238711
46	MP0000427_abnormal_hair_cycle	1.10366324
47	MP0005499_abnormal_olfactory_system	1.09488985
48	MP0005394_taste/olfaction_phenotype	1.09488985
49	MP0003950_abnormal_plasma_membrane	1.07126366
50	MP0005636_abnormal_mineral_homeostasis	1.03851462
51	MP0002282_abnormal_trachea_morphology	1.02129275
52	MP0003656_abnormal_erythrocyte_physiolo	1.00206790
53	MP0009053_abnormal_anal_canal	0.97707084
54	MP0001346_abnormal_lacrimal_gland	0.96060762
55	MP0002168_other_aberrant_phenotype	0.94914877
56	MP0009931_abnormal_skin_appearance	0.91601495
57	MP0005503_abnormal_tendon_morphology	0.90868052
58	MP0002233_abnormal_nose_morphology	0.90691236
59	MP0002133_abnormal_respiratory_system	0.88768987
60	MP0005388_respiratory_system_phenotype	0.88768987
61	MP0001188_hyperpigmentation	0.86591641
62	MP0005310_abnormal_salivary_gland	0.85817999
63	MP0005165_increased_susceptibility_to	0.84287201
64	MP0003705_abnormal_hypodermis_morpholog	0.84129770
65	MP0010030_abnormal_orbit_morphology	0.83192916
66	MP0001851_eye_inflammation	0.83141752
67	MP0008004_abnormal_stomach_pH	0.82068411
68	MP0001485_abnormal_pinna_reflex	0.80914171
69	MP0004883_abnormal_blood_vessel	0.80908111
70	MP0005408_hypopigmentation	0.78302818
71	MP0009379_abnormal_foot_pigmentation	0.78130006
72	MP0003329_amyloid_beta_deposits	0.76509229
73	MP0000367_abnormal_coat/_hair	0.75489235
74	MP0003828_pulmonary_edema	0.74784726
75	MP0005083_abnormal_biliary_tract	0.72428048
76	MP0000858_altered_metastatic_potential	0.71249394
77	MP0002136_abnormal_kidney_physiology	0.71151519
78	MP0001191_abnormal_skin_condition	0.65016253
79	MP0001849_ear_inflammation	0.63780340
80	MP0005166_decreased_susceptibility_to	0.61939406
81	MP0000627_abnormal_mammary_gland	0.61541627
82	MP0001790_abnormal_immune_system	0.61106525
83	MP0005387_immune_system_phenotype	0.61106525
84	MP0001299_abnormal_eye_distance/	0.59847148
85	MP0003075_altered_response_to	0.58840250
86	MP0000647_abnormal_sebaceous_gland	0.58479248
87	MP0003300_gastrointestinal_ulcer	0.56610832
88	MP0002095_abnormal_skin_pigmentation	0.56579525
89	MP0002249_abnormal_larynx_morphology	0.55535755
90	MP0009643_abnormal_urine_homeostasis	0.55443165
91	MP0002909_abnormal_adrenal_gland	0.53442502
92	MP0009765_abnormal_xenobiotic_induced	0.53346135
93	MP0001502_abnormal_circadian_rhythm	0.51774477
94	MP0001270_distended_abdomen	0.50949619
95	MP0001784_abnormal_fluid_regulation	0.50728566
96	MP0004133_heterotaxia	0.50572574
97	MP0003045_fibrosis	0.47856142
98	MP0001879_abnormal_lymphatic_vessel	0.46704126
99	MP0002896_abnormal_bone_mineralization	0.46346008
100	MP0000249_abnormal_blood_vessel	0.46160211

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.09614732
2	Abnormal ciliary motility (HP:0012262)	8.83942624
3	Abnormal respiratory motile cilium morphology (HP:0005938)	8.83782278
4	Abnormal respiratory epithelium morphology (HP:0012253)	8.83782278
5	Absent/shortened dynein arms (HP:0200106)	8.60011878
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	8.60011878
7	Rhinitis (HP:0012384)	8.58326957
8	Chronic bronchitis (HP:0004469)	7.15538837
9	Abnormality of nail color (HP:0100643)	6.56578237
10	Bronchiectasis (HP:0002110)	6.29394210
11	Nasal polyposis (HP:0100582)	5.60132498
12	Abnormality of the nasal mucosa (HP:0000433)	4.63734022
13	Palmoplantar hyperkeratosis (HP:0000972)	4.36304284
14	Oral leukoplakia (HP:0002745)	4.34459130
15	Palmar hyperkeratosis (HP:0010765)	4.14631096
16	Alopecia of scalp (HP:0002293)	3.88888729
17	Bronchitis (HP:0012387)	3.88793206
18	Plantar hyperkeratosis (HP:0007556)	3.86447490
19	Onycholysis (HP:0001806)	3.76774474
20	Hyperactive renin-angiotensin system (HP:0000841)	3.51463396
21	Recurrent sinusitis (HP:0011108)	3.50984206
22	Thick nail (HP:0001805)	3.50509502
23	Erythroderma (HP:0001019)	3.40758744
24	Infertility (HP:0000789)	3.38920536
25	Recurrent otitis media (HP:0000403)	3.31585235
26	Male infertility (HP:0003251)	3.30131069
27	Congenital ichthyosiform erythroderma (HP:0007431)	3.28097605
28	Chronic sinusitis (HP:0011109)	3.24715593
29	Corneal erosion (HP:0200020)	3.17028567
30	Increased IgE level (HP:0003212)	3.12275903
31	Lip pit (HP:0100267)	3.06657053
32	Abnormality of the axillary hair (HP:0100134)	2.88575811
33	Abnormality of secondary sexual hair (HP:0009888)	2.88575811
34	Erythema (HP:0010783)	2.81768401
35	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.75613691
36	Furrowed tongue (HP:0000221)	2.72084174
37	Chronic otitis media (HP:0000389)	2.52960325
38	Hypotrichosis (HP:0001006)	2.49951389
39	Occipital encephalocele (HP:0002085)	2.37370282
40	Absent eyelashes (HP:0000561)	2.35200252
41	Right ventricular cardiomyopathy (HP:0011663)	2.30442253
42	Popliteal pterygium (HP:0009756)	2.28570889
43	Atelectasis (HP:0100750)	2.26318517
44	Nail dystrophy (HP:0008404)	2.22805910
45	Hypoplastic labia majora (HP:0000059)	2.20178357
46	Hyperkalemia (HP:0002153)	2.18283810
47	True hermaphroditism (HP:0010459)	2.16125833
48	Pancreatic fibrosis (HP:0100732)	2.11127931
49	Parakeratosis (HP:0001036)	2.09482938
50	Sparse eyelashes (HP:0000653)	2.02945241
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	10.4065831
52	Abnormality of the labia majora (HP:0012881)	1.99050976
53	Palmoplantar keratoderma (HP:0000982)	1.98436124
54	Decreased circulating renin level (HP:0003351)	1.95022325
55	Abnormality of the salivary glands (HP:0010286)	1.93588642
56	Absent hair (HP:0002298)	1.91934020
57	Hypohidrosis (HP:0000966)	1.91052168
58	Recurrent corneal erosions (HP:0000495)	1.87895907
59	Renal salt wasting (HP:0000127)	1.87448373
60	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.86276256
61	Fragile nails (HP:0001808)	1.82824235
62	Abnormality of permanent molar morphology (HP:0011071)	1.80592829
63	Abnormality of the dental root (HP:0006486)	1.80592829
64	Taurodontia (HP:0000679)	1.80592829
65	Abnormal blistering of the skin (HP:0008066)	1.79707912
66	Gangrene (HP:0100758)	1.77865631
67	Ectropion (HP:0000656)	1.77736298
68	Abnormality of the distal phalanges of the toes (HP:0010182)	1.76078419
69	Tubulointerstitial nephritis (HP:0001970)	1.75543899
70	Abnormality of chloride homeostasis (HP:0011422)	1.74992103
71	Cystic liver disease (HP:0006706)	1.73878901
72	Absent frontal sinuses (HP:0002688)	1.72249687
73	Chronic hepatic failure (HP:0100626)	1.70144188
74	Abnormality of molar morphology (HP:0011070)	1.67645892
75	Abnormality of molar (HP:0011077)	1.67645892
76	Pili torti (HP:0003777)	1.64476834
77	Recurrent bronchitis (HP:0002837)	1.64155585
78	Pancreatic cysts (HP:0001737)	1.63516928
79	Dehydration (HP:0001944)	1.62267469
80	Abnormality of the dental pulp (HP:0006479)	1.61879425
81	Hyperaldosteronism (HP:0000859)	1.60280937
82	Sparse scalp hair (HP:0002209)	1.59707187
83	Woolly hair (HP:0002224)	1.59409867
84	Follicular hyperkeratosis (HP:0007502)	1.57043909
85	Milia (HP:0001056)	1.57000056
86	Abnormal hair laboratory examination (HP:0003328)	1.56814315
87	Abnormality of placental membranes (HP:0011409)	1.55212765
88	Amniotic constriction ring (HP:0009775)	1.55212765
89	Postaxial foot polydactyly (HP:0001830)	1.55045996
90	Bell-shaped thorax (HP:0001591)	1.54374375
91	Oligodontia (HP:0000677)	1.52940508
92	Abnormality of midbrain morphology (HP:0002418)	1.51522760
93	Molar tooth sign on MRI (HP:0002419)	1.51522760
94	Nephronophthisis (HP:0000090)	1.50523403
95	Pruritus (HP:0000989)	1.50126953
96	Abnormality of renin-angiotensin system (HP:0000847)	1.46005061
97	Labial hypoplasia (HP:0000066)	1.40027227
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.39192743
99	Autoamputation (HP:0001218)	1.37779601
100	Corneal dystrophy (HP:0001131)	1.37329997

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	8.65499938
2	EPHA2	5.06241446
3	MST4	4.68183774
4	MAP3K2	3.91393685
5	MST1R	3.11187709
6	STK24	2.85924461
7	MAP3K3	2.58447470
8	MAPKAPK3	2.30027722
9	ERBB3	2.11607143
10	MAP3K12	2.06772963
11	RIPK1	1.81646283
12	TGFBR1	1.77302054
13	LMTK2	1.76356829
14	LATS1	1.73408484
15	TRPM7	1.72699803
16	CSK	1.68200023
17	FER	1.57110147
18	MET	1.49739414
19	STK38L	1.46317125
20	BCR	1.36863807
21	STK39	1.36473078
22	FGFR3	1.32322059
23	NME1	1.24297262
24	MAP3K7	1.23037769
25	NEK6	1.20206444
26	EPHA3	1.16386581
27	BMPR2	1.15566547
28	SMG1	1.14592781
29	FRK	1.14455894
30	PBK	1.14024922
31	MAP3K6	1.13459330
32	EPHB1	1.08977841
33	EEF2K	0.97722919
34	STK38	0.89536104
35	STK10	0.88090260
36	MARK2	0.84705827
37	NLK	0.76318893
38	LRRK2	0.73631000
39	PDGFRB	0.73346354
40	GRK6	0.70263816
41	TTK	0.67964431
42	TBK1	0.64881815
43	IRAK1	0.64803511
44	SGK1	0.62270014
45	SGK223	0.59743174
46	SGK494	0.59743174
47	MYLK	0.58572904
48	JAK1	0.56710797
49	ICK	0.54019504
50	FGFR1	0.53387807
51	PTK2	0.48865763
52	BRSK2	0.48145176
53	CDK6	0.45879967
54	PTK2B	0.45722358
55	OXSR1	0.44316627
56	TESK1	0.43983421
57	PRKAA2	0.43746688
58	ERBB2	0.43001466
59	LATS2	0.42989040
60	PIK3CA	0.41248543
61	PRKCD	0.41080852
62	MAP3K13	0.41050007
63	ABL1	0.40942471
64	RPS6KB2	0.39588054
65	STK3	0.39242485
66	PRKCI	0.39130508
67	DMPK	0.38610026
68	SCYL2	0.38171522
69	CDC42BPA	0.35572121
70	RET	0.35187022
71	ACVR1B	0.34540728
72	PTK6	0.33709747
73	MELK	0.31459805
74	TAOK1	0.29439912
75	SGK2	0.28775466
76	EGFR	0.28218333
77	MAP3K1	0.27625332
78	RPS6KB1	0.27437476
79	EPHA4	0.26924669
80	ADRBK1	0.26789320
81	BMPR1B	0.26441770
82	PAK4	0.26117070
83	IKBKB	0.25572741
84	HIPK2	0.25193067
85	ROCK1	0.25131056
86	PRKCE	0.24806698
87	IKBKE	0.24431205
88	FYN	0.23897518
89	SRC	0.23613979
90	PDPK1	0.23410753
91	IGF1R	0.23187893
92	MAP3K9	0.23033539
93	FGFR4	0.22997873
94	SGK3	0.22755693
95	CAMK2G	0.22511457
96	MAP3K14	0.21811584
97	TYK2	0.21285025
98	TGFBR2	0.20273745
99	PRKCQ	0.19380368
100	ROCK2	0.19161592

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	4.18914524
2	Histidine metabolism_Homo sapiens_hsa00340	4.02076918
3	Phenylalanine metabolism_Homo sapiens_hsa00360	3.83351391
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.59624741
5	Linoleic acid metabolism_Homo sapiens_hsa00591	3.40713056
6	Chemical carcinogenesis_Homo sapiens_hsa05204	3.37534277
7	Tyrosine metabolism_Homo sapiens_hsa00350	3.23718605
8	Retinol metabolism_Homo sapiens_hsa00830	2.67207318
9	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.30803294
10	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.24224885
11	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.23338554
12	beta-Alanine metabolism_Homo sapiens_hsa00410	2.18857883
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.11995556
14	Sphingolipid metabolism_Homo sapiens_hsa00600	2.07102791
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.81876009
16	ABC transporters_Homo sapiens_hsa02010	1.65540628
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64916864
18	Glutathione metabolism_Homo sapiens_hsa00480	1.57716977
19	Circadian rhythm_Homo sapiens_hsa04710	1.44702084
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.33664360
21	* Amoebiasis_Homo sapiens_hsa05146	1.29838034
22	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.25067564
23	Adherens junction_Homo sapiens_hsa04520	1.21257505
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18051693
25	Tight junction_Homo sapiens_hsa04530	1.17633994
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.15879215
27	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.10898305
28	Caffeine metabolism_Homo sapiens_hsa00232	1.05449479
29	Arginine biosynthesis_Homo sapiens_hsa00220	1.04715359
30	Choline metabolism in cancer_Homo sapiens_hsa05231	1.00725141
31	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.94165628
32	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.94090898
33	Huntingtons disease_Homo sapiens_hsa05016	0.93432904
34	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.92399336
35	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.90084521
36	Fatty acid degradation_Homo sapiens_hsa00071	0.89322501
37	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.87937185
38	Salivary secretion_Homo sapiens_hsa04970	0.86444396
39	Hepatitis C_Homo sapiens_hsa05160	0.84648946
40	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.84471633
41	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80049503
42	ECM-receptor interaction_Homo sapiens_hsa04512	0.76264024
43	Complement and coagulation cascades_Homo sapiens_hsa04610	0.75936151
44	Pancreatic secretion_Homo sapiens_hsa04972	0.68618305
45	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.67388654
46	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.67231365
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66967836
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.65307434
49	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.65106265
50	GnRH signaling pathway_Homo sapiens_hsa04912	0.62603471
51	VEGF signaling pathway_Homo sapiens_hsa04370	0.59820856
52	Serotonergic synapse_Homo sapiens_hsa04726	0.57916084
53	Pancreatic cancer_Homo sapiens_hsa05212	0.56487351
54	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.53477833
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53164214
56	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53073077
57	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.52376768
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50885784
59	Peroxisome_Homo sapiens_hsa04146	0.50876858
60	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.48063190
61	p53 signaling pathway_Homo sapiens_hsa04115	0.47525180
62	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.46077915
63	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.44634294
64	Proteoglycans in cancer_Homo sapiens_hsa05205	0.44511521
65	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.43174114
66	Renin secretion_Homo sapiens_hsa04924	0.42977002
67	Salmonella infection_Homo sapiens_hsa05132	0.42790551
68	Endocytosis_Homo sapiens_hsa04144	0.40849904
69	Small cell lung cancer_Homo sapiens_hsa05222	0.39778362
70	Toxoplasmosis_Homo sapiens_hsa05145	0.38863663
71	Mineral absorption_Homo sapiens_hsa04978	0.38047992
72	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.37556323
73	Notch signaling pathway_Homo sapiens_hsa04330	0.36872906
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34854849
75	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.34701754
76	Pertussis_Homo sapiens_hsa05133	0.34458985
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31826364
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31517432
79	TNF signaling pathway_Homo sapiens_hsa04668	0.31479486
80	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.31334657
81	Influenza A_Homo sapiens_hsa05164	0.30986928
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30928028
83	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.30192608
84	Ras signaling pathway_Homo sapiens_hsa04014	0.29540501
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.29208556
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.28795148
87	Hippo signaling pathway_Homo sapiens_hsa04390	0.26137421
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24992579
89	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.24821342
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.23982594
91	Malaria_Homo sapiens_hsa05144	0.23208556
92	Focal adhesion_Homo sapiens_hsa04510	0.22449940
93	Renal cell carcinoma_Homo sapiens_hsa05211	0.21173696
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.20873667
95	Tuberculosis_Homo sapiens_hsa05152	0.20814554
96	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.19354458
97	Axon guidance_Homo sapiens_hsa04360	0.19237513
98	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.16678096
99	PPAR signaling pathway_Homo sapiens_hsa03320	0.16496067
100	Phagosome_Homo sapiens_hsa04145	0.16416260

SERPINB3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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