ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organismal water homeostasis (GO:0050891)	8.48118521
2	phosphatidylinositol acyl-chain remodeling (GO:0036149)	8.46519206
3	peptide cross-linking (GO:0018149)	8.38598560
4	phosphatidylserine acyl-chain remodeling (GO:0036150)	8.35095333
5	molting cycle (GO:0042303)	8.14561609
6	hair cycle (GO:0042633)	8.14561609
7	detection of bacterium (GO:0016045)	7.93774934
8	long-chain fatty acid biosynthetic process (GO:0042759)	7.87630689
9	epidermis development (GO:0008544)	7.74309619
10	sequestering of metal ion (GO:0051238)	7.44389554
11	detection of other organism (GO:0098543)	7.24355728
12	keratinocyte proliferation (GO:0043616)	7.05832707
13	water homeostasis (GO:0030104)	7.03775737
14	gap junction assembly (GO:0016264)	6.87369925
15	lipoxygenase pathway (GO:0019372)	6.71973884
16	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	6.70281280
17	positive regulation of monocyte chemotaxis (GO:0090026)	6.69454424
18	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	6.64299106
19	positive regulation of T cell chemotaxis (GO:0010820)	6.50158157
20	regulation of T cell chemotaxis (GO:0010819)	6.50158157
21	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.29652029
22	regulation of natural killer cell differentiation (GO:0032823)	6.05840366
23	linoleic acid metabolic process (GO:0043651)	5.88557201
24	phosphatidylcholine acyl-chain remodeling (GO:0036151)	5.87461117
25	negative regulation of interferon-gamma production (GO:0032689)	5.62129930
26	negative regulation of interleukin-17 production (GO:0032700)	5.19470487
27	phosphatidylserine metabolic process (GO:0006658)	5.12307954
28	skin morphogenesis (GO:0043589)	5.10351021
29	regulation of transforming growth factor beta1 production (GO:0032908)	5.04510753
30	regulation of monocyte chemotaxis (GO:0090025)	4.87954081
31	intermediate filament organization (GO:0045109)	4.74079028
32	intermediate filament cytoskeleton organization (GO:0045104)	4.66861123
33	hemidesmosome assembly (GO:0031581)	4.52239734
34	intermediate filament-based process (GO:0045103)	4.52238096
35	establishment of planar polarity (GO:0001736)	4.40638361
36	establishment of tissue polarity (GO:0007164)	4.40638361
37	detection of external biotic stimulus (GO:0098581)	4.12686409
38	alditol phosphate metabolic process (GO:0052646)	4.12167059
39	phospholipid catabolic process (GO:0009395)	4.10094611
40	ectoderm development (GO:0007398)	4.09423619
41	surfactant homeostasis (GO:0043129)	4.04074268
42	regulation of lymphocyte chemotaxis (GO:1901623)	3.92977843
43	ceramide biosynthetic process (GO:0046513)	3.86584360
44	positive regulation of glomerulus development (GO:0090193)	3.79576377
45	positive regulation of granulocyte chemotaxis (GO:0071624)	3.67393915
46	positive regulation of p38MAPK cascade (GO:1900745)	3.60440221
47	epithelium development (GO:0060429)	3.56068424
48	chemical homeostasis within a tissue (GO:0048875)	3.50521365
49	detection of biotic stimulus (GO:0009595)	3.47361500
50	phosphatidylglycerol metabolic process (GO:0046471)	3.46456690
51	keratinocyte development (GO:0003334)	3.46349587
52	interleukin-6-mediated signaling pathway (GO:0070102)	3.44186012
53	defense response to Gram-negative bacterium (GO:0050829)	3.39380891
54	peptidyl-proline hydroxylation (GO:0019511)	3.27603372
55	regulation of cell proliferation involved in kidney development (GO:1901722)	3.17557263
56	positive regulation of T cell migration (GO:2000406)	3.14550899
57	defense response to fungus (GO:0050832)	3.11092487
58	positive regulation of interleukin-6 production (GO:0032755)	2.91040049
59	regulation of interleukin-17 production (GO:0032660)	2.91000247
60	regulation of T cell migration (GO:2000404)	2.88930185
61	regulation of transmission of nerve impulse (GO:0051969)	2.88413455
62	negative regulation of keratinocyte proliferation (GO:0010839)	2.86967979
63	positive regulation of epidermis development (GO:0045684)	2.86600058
64	phosphatidic acid metabolic process (GO:0046473)	2.84796931
65	phosphatidic acid biosynthetic process (GO:0006654)	2.84796931
66	regulation of natural killer cell activation (GO:0032814)	2.81321124
67	lateral sprouting from an epithelium (GO:0060601)	2.76538296
68	regulation of interleukin-6 production (GO:0032675)	2.76320255
69	epithelial cell differentiation (GO:0030855)	2.75259522
70	response to UV-B (GO:0010224)	2.71782452
71	intestinal epithelial cell development (GO:0060576)	2.67113748
72	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.66225323
73	4-hydroxyproline metabolic process (GO:0019471)	2.63506915
74	positive regulation of transforming growth factor beta production (GO:0071636)	2.62222757
75	regulation of T-helper 2 cell differentiation (GO:0045628)	2.59153685
76	regulation of p38MAPK cascade (GO:1900744)	2.58656563
77	eyelid development in camera-type eye (GO:0061029)	2.55738116
78	positive regulation of type 2 immune response (GO:0002830)	2.52508491
79	positive regulation of lymphocyte migration (GO:2000403)	2.51817470
80	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.50494358
81	positive regulation of epidermal cell differentiation (GO:0045606)	2.50321927
82	regulation of neuron projection regeneration (GO:0070570)	2.49558166
83	regulation of axon regeneration (GO:0048679)	2.49558166
84	regulation of keratinocyte differentiation (GO:0045616)	2.48327023
85	regulation of glomerulus development (GO:0090192)	2.47651677
86	positive regulation of chemokine secretion (GO:0090197)	2.46697225
87	sphingolipid biosynthetic process (GO:0030148)	2.46500691
88	regulation of granulocyte chemotaxis (GO:0071622)	2.45732520
89	regulation of keratinocyte proliferation (GO:0010837)	2.45724936
90	response to zinc ion (GO:0010043)	2.45601700
91	protein hydroxylation (GO:0018126)	2.44970920
92	regulation of collagen biosynthetic process (GO:0032965)	2.44561005
93	male genitalia development (GO:0030539)	2.41526136
94	response to fungus (GO:0009620)	2.40597020
95	keratinization (GO:0031424)	19.9080427
96	establishment of skin barrier (GO:0061436)	15.3148603
97	keratinocyte differentiation (GO:0030216)	13.3203909
98	regulation of water loss via skin (GO:0033561)	13.1527542
99	desmosome organization (GO:0002934)	10.4287596
100	epidermal cell differentiation (GO:0009913)	10.0753691

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	6.20322595
2	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.86535058
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.71595344
4	HIF1A_21447827_ChIP-Seq_MCF-7_Human	3.09245760
5	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.78055678
6	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.78055678
7	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.48822357
8	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.20721745
9	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.08520645
10	TP63_23658742_ChIP-Seq_EP156T_Human	2.07207436
11	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.05816164
12	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.03402622
13	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.6437257
14	SOX2_20726797_ChIP-Seq_SW620_Human	1.95706678
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.87915377
16	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.82761275
17	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.78203263
18	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.76900016
19	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.76863107
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.75894062
21	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.63248765
22	CJUN_26792858_Chip-Seq_BT549_Human	1.61274101
23	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.60255293
24	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.57087328
25	ZNF263_19887448_ChIP-Seq_K562_Human	1.56403718
26	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.55838801
27	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.53100219
28	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.51504973
29	ERG_20517297_ChIP-Seq_VCAP_Human	1.51414803
30	RXR_22108803_ChIP-Seq_LS180_Human	1.47852151
31	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.47676949
32	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.46003874
33	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.43574768
34	* ATF3_27146783_Chip-Seq_COLON_Human	1.42114685
35	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.36784905
36	EGR1_19032775_ChIP-ChIP_M12_Human	1.36151230
37	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.35054285
38	TP63_22573176_ChIP-Seq_HFKS_Human	1.30363021
39	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.26799304
40	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.24454543
41	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.21243042
42	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.20744247
43	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.13994117
44	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.13580949
45	RBPJ_21746931_ChIP-Seq_IB4_Human	1.12226427
46	TP53_16413492_ChIP-PET_HCT116_Human	1.11000604
47	KLF5_25053715_ChIP-Seq_YYC3_Human	1.10670063
48	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.10527235
49	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.09709019
50	AHR_22903824_ChIP-Seq_MCF-7_Human	1.04885244
51	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.04766278
52	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.04144927
53	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.02496104
54	CLOCK_20551151_ChIP-Seq_293T_Human	1.00488121
55	TP53_18474530_ChIP-ChIP_U2OS_Human	1.00012462
56	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.99833328
57	GATA4_25053715_ChIP-Seq_YYC3_Human	0.97880613
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.96629777
59	GATA6_25053715_ChIP-Seq_YYC3_Human	0.95636002
60	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.94116019
61	RACK7_27058665_Chip-Seq_MCF-7_Human	0.94081418
62	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.92550447
63	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.91280841
64	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.89721075
65	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.88807199
66	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.87381949
67	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.86299579
68	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.84663909
69	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.83459394
70	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.82494008
71	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.82426921
72	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.82140473
73	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.81829697
74	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.81693410
75	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.81693410
76	SMC4_20622854_ChIP-Seq_HELA_Human	0.79640745
77	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.79290714
78	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.79251589
79	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.79087579
80	NCOR_22424771_ChIP-Seq_293T_Human	0.77511831
81	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.77089927
82	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.77042177
83	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.75175222
84	GATA2_19941826_ChIP-Seq_K562_Human	0.75132390
85	VDR_22108803_ChIP-Seq_LS180_Human	0.74524490
86	CDX2_22108803_ChIP-Seq_LS180_Human	0.72788969
87	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.72013630
88	E2F1_20622854_ChIP-Seq_HELA_Human	0.71506959
89	BCOR_27268052_Chip-Seq_Bcells_Human	0.70424511
90	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.69976461
91	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.68970738
92	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.68401280
93	CEBPB_22108803_ChIP-Seq_LS180_Human	0.68206576
94	P53_21459846_ChIP-Seq_SAOS-2_Human	0.65226922
95	CTCF_20526341_ChIP-Seq_ESCs_Human	0.65096903
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.64592788
97	ETV1_20927104_ChIP-Seq_GIST48_Human	0.63677497
98	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.63241392
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.62003610
100	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.61713475

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002796_impaired_skin_barrier	9.12445718
2	MP0005275_abnormal_skin_tensile	6.83784651
3	MP0000579_abnormal_nail_morphology	6.37009175
4	MP0010234_abnormal_vibrissa_follicle	5.67107800
5	MP0005501_abnormal_skin_physiology	5.36728202
6	MP0003453_abnormal_keratinocyte_physiol	3.60188399
7	MP0004885_abnormal_endolymph	3.42569838
8	MP0001216_abnormal_epidermal_layer	3.30516665
9	MP0005377_hearing/vestibular/ear_phenot	3.16900004
10	MP0003878_abnormal_ear_physiology	3.16900004
11	MP0002060_abnormal_skin_morphology	3.02003271
12	MP0003941_abnormal_skin_development	2.97364308
13	MP0010771_integument_phenotype	2.88312958
14	MP0010678_abnormal_skin_adnexa	2.68132710
15	MP0004264_abnormal_extraembryonic_tissu	2.31502208
16	MP0004947_skin_inflammation	2.27648025
17	MP0000383_abnormal_hair_follicle	2.22814383
18	MP0000467_abnormal_esophagus_morphology	2.20957877
19	MP0001188_hyperpigmentation	2.04903987
20	MP0003705_abnormal_hypodermis_morpholog	2.01286150
21	MP0003191_abnormal_cellular_cholesterol	1.95997814
22	MP0004381_abnormal_hair_follicle	1.93121942
23	MP0000762_abnormal_tongue_morphology	1.84698116
24	MP0005409_darkened_coat_color	1.76401888
25	MP0000377_abnormal_hair_follicle	1.76347934
26	MP0002098_abnormal_vibrissa_morphology	1.74681592
27	MP0009931_abnormal_skin_appearance	1.68545700
28	MP0004782_abnormal_surfactant_physiolog	1.66709396
29	MP0003566_abnormal_cell_adhesion	1.51138766
30	MP0003950_abnormal_plasma_membrane	1.41551054
31	MP0001191_abnormal_skin_condition	1.38067714
32	MP0005023_abnormal_wound_healing	1.27569941
33	MP0010352_gastrointestinal_tract_polyps	1.23556845
34	MP0000427_abnormal_hair_cycle	1.14174199
35	MP0000465_gastrointestinal_hemorrhage	1.10600129
36	MP0008004_abnormal_stomach_pH	1.09954731
37	MP0000367_abnormal_coat/_hair	1.09715723
38	MP0000647_abnormal_sebaceous_gland	1.05027800
39	MP0003011_delayed_dark_adaptation	1.02806119
40	MP0002095_abnormal_skin_pigmentation	1.01726614
41	MP0009053_abnormal_anal_canal	1.00582879
42	MP0000566_synostosis	0.99326960
43	MP0001851_eye_inflammation	0.97517211
44	MP0009379_abnormal_foot_pigmentation	0.87854042
45	MP0004043_abnormal_pH_regulation	0.75048329
46	MP0001784_abnormal_fluid_regulation	0.73061328
47	MP0006082_CNS_inflammation	0.72987481
48	MP0002006_tumorigenesis	0.71966323
49	MP0002177_abnormal_outer_ear	0.71633192
50	MP0004272_abnormal_basement_membrane	0.63037817
51	MP0004185_abnormal_adipocyte_glucose	0.58855607
52	MP0000627_abnormal_mammary_gland	0.56243331
53	MP0001243_abnormal_dermal_layer	0.53859564
54	MP0002111_abnormal_tail_morphology	0.53045974
55	MP0001485_abnormal_pinna_reflex	0.51825080
56	MP0000858_altered_metastatic_potential	0.51512655
57	MP0003300_gastrointestinal_ulcer	0.48738508
58	MP0002877_abnormal_melanocyte_morpholog	0.44794183
59	MP0009785_altered_susceptibility_to	0.42423912
60	MP0002332_abnormal_exercise_endurance	0.41998084
61	MP0003315_abnormal_perineum_morphology	0.38737321
62	MP0008260_abnormal_autophagy	0.37507011
63	MP0002234_abnormal_pharynx_morphology	0.35804569
64	MP0001790_abnormal_immune_system	0.34863580
65	MP0005387_immune_system_phenotype	0.34863580
66	MP0005166_decreased_susceptibility_to	0.34658425
67	MP0008438_abnormal_cutaneous_collagen	0.34562635
68	MP0002282_abnormal_trachea_morphology	0.32930515
69	MP0003448_altered_tumor_morphology	0.32732791
70	MP0003763_abnormal_thymus_physiology	0.32409192
71	MP0005666_abnormal_adipose_tissue	0.32129335
72	MP0003755_abnormal_palate_morphology	0.32101304
73	MP0009333_abnormal_splenocyte_physiolog	0.32093213
74	MP0000685_abnormal_immune_system	0.31933219
75	MP0005164_abnormal_response_to	0.31746581
76	MP0002009_preneoplasia	0.29297761
77	MP0002133_abnormal_respiratory_system	0.27145730
78	MP0005388_respiratory_system_phenotype	0.27145730
79	MP0001340_abnormal_eyelid_morphology	0.26766238
80	MP0002166_altered_tumor_susceptibility	0.25694305
81	MP0005375_adipose_tissue_phenotype	0.25345958
82	MP0001177_atelectasis	0.24322637
83	MP0001905_abnormal_dopamine_level	0.24032868
84	MP0003436_decreased_susceptibility_to	0.23031478
85	MP0000015_abnormal_ear_pigmentation	0.20212060
86	MP0002148_abnormal_hypersensitivity_rea	0.20194000
87	MP0000470_abnormal_stomach_morphology	0.19077007
88	MP0005197_abnormal_uvea_morphology	0.18268176
89	MP0005193_abnormal_anterior_eye	0.18026200
90	MP0003828_pulmonary_edema	0.17556212
91	MP0005257_abnormal_intraocular_pressure	0.15946721
92	MP0004197_abnormal_fetal_growth/weight/	0.15433435
93	MP0001765_abnormal_ion_homeostasis	0.14623296
94	MP0009780_abnormal_chondrocyte_physiolo	0.14519290
95	MP0010030_abnormal_orbit_morphology	0.14190806
96	MP0003091_abnormal_cell_migration	0.14152018
97	MP0005076_abnormal_cell_differentiation	0.13830244
98	MP0005025_abnormal_response_to	0.13363064
99	MP0001501_abnormal_sleep_pattern	0.13262491
100	MP0005174_abnormal_tail_pigmentation	0.12902103

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Palmoplantar hyperkeratosis (HP:0000972)	9.44636435
2	Palmar hyperkeratosis (HP:0010765)	8.98328423
3	Erythroderma (HP:0001019)	8.89298796
4	Oral leukoplakia (HP:0002745)	8.64932663
5	Plantar hyperkeratosis (HP:0007556)	7.69897546
6	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.27738347
7	Increased IgE level (HP:0003212)	7.25685605
8	Alopecia of scalp (HP:0002293)	7.20977794
9	Congenital ichthyosiform erythroderma (HP:0007431)	7.15918831
10	Parakeratosis (HP:0001036)	6.19130331
11	Thick nail (HP:0001805)	6.18609176
12	Onycholysis (HP:0001806)	5.91832326
13	Erythema (HP:0010783)	5.70995538
14	Corneal erosion (HP:0200020)	5.57316650
15	Conjunctival hamartoma (HP:0100780)	5.40836178
16	Abnormality of secondary sexual hair (HP:0009888)	5.28432932
17	Abnormality of the axillary hair (HP:0100134)	5.28432932
18	Hypotrichosis (HP:0001006)	5.03958373
19	Gangrene (HP:0100758)	4.43495157
20	Ectropion (HP:0000656)	4.22278856
21	Palmoplantar keratoderma (HP:0000982)	4.17200820
22	Hypohidrosis (HP:0000966)	4.16433923
23	Follicular hyperkeratosis (HP:0007502)	4.08188901
24	Nail dystrophy (HP:0008404)	4.02479148
25	Amniotic constriction ring (HP:0009775)	4.01038531
26	Abnormality of placental membranes (HP:0011409)	4.01038531
27	Absent eyelashes (HP:0000561)	3.74333226
28	Sparse eyelashes (HP:0000653)	3.72516895
29	Right ventricular cardiomyopathy (HP:0011663)	3.71936574
30	Pustule (HP:0200039)	3.63934954
31	Hamartoma of the eye (HP:0010568)	3.54746439
32	Absent hair (HP:0002298)	3.41044625
33	Furrowed tongue (HP:0000221)	3.34054200
34	Abnormal blistering of the skin (HP:0008066)	3.27562775
35	Lip pit (HP:0100267)	3.06811474
36	Woolly hair (HP:0002224)	2.91537807
37	Autoamputation (HP:0001218)	2.91051496
38	Fragile nails (HP:0001808)	2.86302989
39	Abnormality of the salivary glands (HP:0010286)	2.73983827
40	Pruritus (HP:0000989)	2.65878671
41	Lack of skin elasticity (HP:0100679)	2.60353522
42	Recurrent corneal erosions (HP:0000495)	2.58665637
43	Multifactorial inheritance (HP:0001426)	2.51318748
44	Sparse scalp hair (HP:0002209)	2.43336349
45	Paralysis (HP:0003470)	2.42552602
46	Keratoconjunctivitis sicca (HP:0001097)	2.41679380
47	Blepharitis (HP:0000498)	2.39403006
48	Laryngomalacia (HP:0001601)	2.35916414
49	Pili torti (HP:0003777)	2.28549911
50	Urticaria (HP:0001025)	2.27910326
51	Ridged nail (HP:0001807)	2.23699431
52	Dehydration (HP:0001944)	2.20183705
53	Keratoconjunctivitis (HP:0001096)	2.18933468
54	Abnormal hair laboratory examination (HP:0003328)	2.16820904
55	Hyperhidrosis (HP:0000975)	2.06729994
56	Melanocytic nevus (HP:0000995)	2.06059829
57	Corneal dystrophy (HP:0001131)	2.03267167
58	Abnormality of nail color (HP:0100643)	13.6011441
59	Milia (HP:0001056)	1.99483053
60	Hypergammaglobulinemia (HP:0010702)	1.98719518
61	Recurrent bacterial skin infections (HP:0005406)	1.95702022
62	Skin ulcer (HP:0200042)	1.84532960
63	Natal tooth (HP:0000695)	1.77575886
64	Anonychia (HP:0001798)	1.77454957
65	Carious teeth (HP:0000670)	1.75938826
66	Brittle hair (HP:0002299)	1.71855427
67	Xerostomia (HP:0000217)	1.71014118
68	Eczematoid dermatitis (HP:0000976)	1.70043976
69	Hypoplastic labia majora (HP:0000059)	1.65183551
70	Sepsis (HP:0100806)	1.62537868
71	Verrucae (HP:0200043)	1.60155002
72	Papilloma (HP:0012740)	1.60155002
73	Hamartoma (HP:0010566)	1.59068416
74	Advanced eruption of teeth (HP:0006288)	1.59009546
75	Hypoplastic toenails (HP:0001800)	1.58856054
76	Preauricular skin tag (HP:0000384)	1.58547420
77	Abnormalities of placenta or umbilical cord (HP:0001194)	1.55093984
78	Abnormality of the fingernails (HP:0001231)	1.54305708
79	Abnormality of hair growth rate (HP:0011363)	1.54116995
80	Slow-growing hair (HP:0002217)	1.54116995
81	Dry skin (HP:0000958)	1.53720048
82	Selective tooth agenesis (HP:0001592)	1.49492737
83	Dry hair (HP:0011359)	1.49031343
84	Abnormality of the labia majora (HP:0012881)	1.48865634
85	Ankyloglossia (HP:0010296)	1.46996407
86	Squamous cell carcinoma (HP:0002860)	1.46965550
87	Fine hair (HP:0002213)	1.46437049
88	Knee flexion contracture (HP:0006380)	1.33137179
89	Skin tags (HP:0010609)	1.30172127
90	Split foot (HP:0001839)	1.29002817
91	Curly hair (HP:0002212)	1.27993015
92	Recurrent skin infections (HP:0001581)	1.27082918
93	Popliteal pterygium (HP:0009756)	1.26478733
94	Duplicated collecting system (HP:0000081)	1.26318168
95	Acanthocytosis (HP:0001927)	1.21966790
96	Acanthosis nigricans (HP:0000956)	1.18806925
97	Axonal loss (HP:0003447)	1.17289029
98	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.12322785
99	Ventricular tachycardia (HP:0004756)	1.12012825
100	Generalized hyperpigmentation (HP:0007440)	1.11779059

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TGFBR1	4.30491225
2	MAP3K9	4.28441447
3	EPHA2	4.02627050
4	MST4	3.99299790
5	MAP3K6	3.98682337
6	LATS2	3.34429576
7	EPHA3	3.32431500
8	FER	3.19408247
9	MST1R	2.84813527
10	MAP3K2	2.32015185
11	MAP3K3	2.30029125
12	STK24	2.19151185
13	EPHB1	2.19048633
14	EPHB2	2.10085561
15	LATS1	2.01714557
16	FGFR4	1.93432422
17	FGFR3	1.91344025
18	RIPK1	1.89216863
19	ERN1	1.84185603
20	MAP3K13	1.80492081
21	BCR	1.76874483
22	PBK	1.70335371
23	FGFR1	1.68937405
24	ARAF	1.55853434
25	MAPKAPK3	1.49329837
26	IRAK1	1.48584634
27	SGK223	1.41805294
28	SGK494	1.41805294
29	IKBKB	1.37792547
30	MAP3K12	1.37735782
31	MET	1.27313322
32	ERBB3	1.23131629
33	STK38L	1.19032608
34	BMPR1B	1.17884701
35	GRK6	1.14883661
36	TRPM7	1.11478218
37	LMTK2	1.10160388
38	PTK2	1.09547482
39	IRAK3	1.04452213
40	BMPR2	1.01840114
41	MAP3K1	1.01650310
42	SIK3	0.94607998
43	BMX	0.94577655
44	NLK	0.91499927
45	MAP2K6	0.86512155
46	MAPK7	0.72611945
47	JAK3	0.71715137
48	TAOK1	0.69671186
49	STK38	0.67308357
50	JAK1	0.63956207
51	IKBKE	0.63349560
52	MAPKAPK2	0.62317976
53	MARK2	0.61477392
54	PIK3CA	0.61313854
55	MOS	0.61146667
56	NEK6	0.60953579
57	STK3	0.59672795
58	KSR2	0.59135998
59	RET	0.58250114
60	GSK3A	0.53042672
61	SIK1	0.52608964
62	PKN1	0.51619020
63	PIM2	0.51091158
64	EIF2AK3	0.50133146
65	PDGFRA	0.49091875
66	PDGFRB	0.48455776
67	HIPK2	0.48074127
68	CDK12	0.45520040
69	CDK6	0.43035417
70	BLK	0.42582685
71	PRKCE	0.41990638
72	MAP3K14	0.41604802
73	CDK9	0.41187745
74	PRPF4B	0.41007696
75	TYK2	0.40693665
76	KIT	0.38592175
77	KSR1	0.37684895
78	TAOK3	0.33215978
79	MYLK	0.33153972
80	YES1	0.32096032
81	ABL1	0.30907079
82	MTOR	0.30446563
83	TGFBR2	0.29601774
84	CDC42BPA	0.28642899
85	PRKCI	0.27752405
86	HCK	0.27381560
87	ABL2	0.23773831
88	CSK	0.22817727
89	SGK1	0.22137520
90	MAP3K7	0.21071798
91	PAK4	0.20836224
92	TAOK2	0.20780541
93	CASK	0.20750904
94	PTK6	0.19869074
95	PRKCD	0.19499506
96	ADRBK1	0.17990324
97	PAK2	0.17868568
98	IGF1R	0.17438268
99	CDK8	0.16632092
100	FLT3	0.16254821

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	7.35338399
2	Linoleic acid metabolism_Homo sapiens_hsa00591	6.14509274
3	Ether lipid metabolism_Homo sapiens_hsa00565	4.28002698
4	Arachidonic acid metabolism_Homo sapiens_hsa00590	4.03067945
5	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.16762752
6	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.17633457
7	VEGF signaling pathway_Homo sapiens_hsa04370	2.05299061
8	GnRH signaling pathway_Homo sapiens_hsa04912	2.00295346
9	Sphingolipid metabolism_Homo sapiens_hsa00600	1.99475570
10	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.74949272
11	Long-term depression_Homo sapiens_hsa04730	1.69815022
12	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.67474927
13	Pertussis_Homo sapiens_hsa05133	1.67274345
14	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.52236242
15	Histidine metabolism_Homo sapiens_hsa00340	1.50622863
16	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.43667681
17	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.41724656
18	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.40871000
19	* Amoebiasis_Homo sapiens_hsa05146	1.31768735
20	TNF signaling pathway_Homo sapiens_hsa04668	1.28025055
21	Serotonergic synapse_Homo sapiens_hsa04726	1.22339686
22	Choline metabolism in cancer_Homo sapiens_hsa05231	1.20159576
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.16974054
24	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.14933369
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.09384913
26	African trypanosomiasis_Homo sapiens_hsa05143	1.07818440
27	Salmonella infection_Homo sapiens_hsa05132	1.07534824
28	Ras signaling pathway_Homo sapiens_hsa04014	0.99360496
29	Fat digestion and absorption_Homo sapiens_hsa04975	0.98657736
30	Circadian rhythm_Homo sapiens_hsa04710	0.92855647
31	Malaria_Homo sapiens_hsa05144	0.89956148
32	Legionellosis_Homo sapiens_hsa05134	0.89298703
33	Prion diseases_Homo sapiens_hsa05020	0.87501702
34	Platelet activation_Homo sapiens_hsa04611	0.83973344
35	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.82547506
36	Phototransduction_Homo sapiens_hsa04744	0.81127671
37	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.78601522
38	Phenylalanine metabolism_Homo sapiens_hsa00360	0.76057592
39	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.74501161
40	Influenza A_Homo sapiens_hsa05164	0.72596634
41	Graft-versus-host disease_Homo sapiens_hsa05332	0.71952643
42	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.69784851
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65931675
44	p53 signaling pathway_Homo sapiens_hsa04115	0.65330324
45	Renal cell carcinoma_Homo sapiens_hsa05211	0.64302801
46	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.63244402
47	Pancreatic secretion_Homo sapiens_hsa04972	0.61504492
48	Renin secretion_Homo sapiens_hsa04924	0.61067199
49	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.60549802
50	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.60543334
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.58422036
52	ECM-receptor interaction_Homo sapiens_hsa04512	0.53033956
53	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.51752707
54	MAPK signaling pathway_Homo sapiens_hsa04010	0.49371618
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.49231456
56	Tuberculosis_Homo sapiens_hsa05152	0.48457831
57	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.48232575
58	Acute myeloid leukemia_Homo sapiens_hsa05221	0.48029121
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43320694
60	Bladder cancer_Homo sapiens_hsa05219	0.42299265
61	ErbB signaling pathway_Homo sapiens_hsa04012	0.41757387
62	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.40988699
63	Glioma_Homo sapiens_hsa05214	0.40822532
64	Adherens junction_Homo sapiens_hsa04520	0.40702686
65	MicroRNAs in cancer_Homo sapiens_hsa05206	0.38564034
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37628366
67	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37595793
68	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36721869
69	Mineral absorption_Homo sapiens_hsa04978	0.36306336
70	Sulfur metabolism_Homo sapiens_hsa00920	0.35193883
71	Proteoglycans in cancer_Homo sapiens_hsa05205	0.35135995
72	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.33600670
73	Pancreatic cancer_Homo sapiens_hsa05212	0.32848579
74	Retinol metabolism_Homo sapiens_hsa00830	0.32402195
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.32280061
76	Hepatitis C_Homo sapiens_hsa05160	0.30204043
77	FoxO signaling pathway_Homo sapiens_hsa04068	0.29558609
78	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.28557111
79	Melanogenesis_Homo sapiens_hsa04916	0.27405330
80	ABC transporters_Homo sapiens_hsa02010	0.26292500
81	Shigellosis_Homo sapiens_hsa05131	0.24812715
82	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.24382628
83	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.24201144
84	Gastric acid secretion_Homo sapiens_hsa04971	0.24167504
85	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23843431
86	Chemokine signaling pathway_Homo sapiens_hsa04062	0.21905983
87	Galactose metabolism_Homo sapiens_hsa00052	0.21837900
88	Toxoplasmosis_Homo sapiens_hsa05145	0.21718171
89	Thyroid cancer_Homo sapiens_hsa05216	0.21700951
90	Estrogen signaling pathway_Homo sapiens_hsa04915	0.20883324
91	Long-term potentiation_Homo sapiens_hsa04720	0.20671646
92	Measles_Homo sapiens_hsa05162	0.20550863
93	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.20351872
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.20076020
95	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.18286574
96	Tight junction_Homo sapiens_hsa04530	0.18233154
97	Pathways in cancer_Homo sapiens_hsa05200	0.17725766
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.17465834
99	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.17390027
100	Rap1 signaling pathway_Homo sapiens_hsa04015	0.17324284

SERPINB4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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