ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of metalloenzyme activity (GO:0048552)	4.04800302
2	Golgi transport vesicle coating (GO:0048200)	3.70026967
3	COPI coating of Golgi vesicle (GO:0048205)	3.70026967
4	angiotensin maturation (GO:0002003)	3.52507333
5	endothelium development (GO:0003158)	3.51494986
6	barbed-end actin filament capping (GO:0051016)	3.44852927
7	NADH metabolic process (GO:0006734)	3.36775496
8	pinocytosis (GO:0006907)	3.36108275
9	peptide catabolic process (GO:0043171)	3.33846941
10	fibril organization (GO:0097435)	3.27250938
11	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.24819351
12	protein maturation by protein folding (GO:0022417)	3.17875505
13	extracellular fibril organization (GO:0043206)	3.16842310
14	cyclooxygenase pathway (GO:0019371)	3.15100024
15	glycosphingolipid catabolic process (GO:0046479)	3.08435754
16	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.03307947
17	glycolipid catabolic process (GO:0019377)	2.99362512
18	response to thyroid hormone (GO:0097066)	2.96044004
19	cellular response to thyroid hormone stimulus (GO:0097067)	2.92419234
20	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.86700448
21	neutrophil activation involved in immune response (GO:0002283)	2.86491898
22	regulation of integrin-mediated signaling pathway (GO:2001044)	2.84642998
23	adhesion of symbiont to host cell (GO:0044650)	2.84447846
24	virion attachment to host cell (GO:0019062)	2.84447846
25	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.83133251
26	thrombin receptor signaling pathway (GO:0070493)	2.79633909
27	protein retention in ER lumen (GO:0006621)	2.79276924
28	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.78521177
29	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.73874601
30	negative regulation of erythrocyte differentiation (GO:0045647)	2.71035891
31	adhesion of symbiont to host (GO:0044406)	2.67330126
32	hydrogen peroxide catabolic process (GO:0042744)	2.63227309
33	pentose-phosphate shunt (GO:0006098)	2.61971673
34	renal filtration (GO:0097205)	2.51600154
35	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.51098135
36	angiogenesis involved in wound healing (GO:0060055)	2.50713055
37	hyaluronan catabolic process (GO:0030214)	2.48553315
38	ceramide catabolic process (GO:0046514)	2.46999421
39	glucose catabolic process (GO:0006007)	2.46765704
40	glomerular filtration (GO:0003094)	2.45723762
41	autophagic vacuole fusion (GO:0000046)	2.45696583
42	fructose metabolic process (GO:0006000)	2.44479220
43	L-ascorbic acid metabolic process (GO:0019852)	2.43549034
44	nucleoside diphosphate biosynthetic process (GO:0009133)	2.39811496
45	keratan sulfate catabolic process (GO:0042340)	2.37072645
46	oxaloacetate metabolic process (GO:0006107)	2.36710323
47	oligosaccharide catabolic process (GO:0009313)	2.36356752
48	definitive hemopoiesis (GO:0060216)	2.30225238
49	positive regulation of pseudopodium assembly (GO:0031274)	2.28730576
50	GDP-mannose metabolic process (GO:0019673)	2.27144312
51	transcytosis (GO:0045056)	2.26299754
52	response to interferon-beta (GO:0035456)	2.25632643
53	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.25449312
54	response to peptidoglycan (GO:0032494)	2.25357392
55	UV protection (GO:0009650)	2.24808081
56	NADPH regeneration (GO:0006740)	2.24751894
57	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.24527721
58	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.24397443
59	negative regulation of protein localization to plasma membrane (GO:1903077)	2.23818270
60	negative regulation of humoral immune response (GO:0002921)	2.23345452
61	apoptotic cell clearance (GO:0043277)	2.21852202
62	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.21708793
63	regulation of superoxide anion generation (GO:0032928)	2.21672381
64	xenobiotic catabolic process (GO:0042178)	2.21615345
65	glycoside metabolic process (GO:0016137)	2.21152783
66	glutathione biosynthetic process (GO:0006750)	2.20344215
67	regulation of necrotic cell death (GO:0010939)	2.19886640
68	mature B cell differentiation involved in immune response (GO:0002313)	2.18939550
69	regulation of cellular extravasation (GO:0002691)	2.17814459
70	proline biosynthetic process (GO:0006561)	2.16271321
71	glutathione derivative biosynthetic process (GO:1901687)	2.16261232
72	glutathione derivative metabolic process (GO:1901685)	2.16261232
73	phagocytosis, engulfment (GO:0006911)	2.15299806
74	peptidyl-proline hydroxylation (GO:0019511)	2.15122508
75	hydrogen peroxide metabolic process (GO:0042743)	2.14469736
76	negative regulation of complement activation (GO:0045916)	2.13817349
77	cell volume homeostasis (GO:0006884)	2.13147364
78	regulation of pseudopodium assembly (GO:0031272)	2.12362047
79	immunoglobulin mediated immune response (GO:0016064)	2.12253560
80	positive regulation of receptor recycling (GO:0001921)	2.11588949
81	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.11039570
82	tricarboxylic acid metabolic process (GO:0072350)	2.10920257
83	sphingolipid catabolic process (GO:0030149)	2.10069876
84	ethanol oxidation (GO:0006069)	2.09237428
85	actin filament depolymerization (GO:0030042)	2.08988112
86	membrane lipid catabolic process (GO:0046466)	2.07903292
87	positive regulation of odontogenesis (GO:0042482)	2.07785746
88	regulation of membrane protein ectodomain proteolysis (GO:0051043)	2.07647257
89	regulation of extracellular matrix disassembly (GO:0010715)	2.07579021
90	nonribosomal peptide biosynthetic process (GO:0019184)	2.06185741
91	hypotonic response (GO:0006971)	2.05518957
92	positive regulation of reactive oxygen species metabolic process (GO:2000379)	2.05087888
93	cellular response to cadmium ion (GO:0071276)	2.04630200
94	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.04565501
95	glutathione metabolic process (GO:0006749)	2.04488940
96	vascular endothelial growth factor signaling pathway (GO:0038084)	2.04352701
97	ethanol metabolic process (GO:0006067)	2.04281796
98	arachidonic acid metabolic process (GO:0019369)	2.04129251
99	membrane invagination (GO:0010324)	2.03797706
100	positive regulation of fatty acid biosynthetic process (GO:0045723)	2.03448369

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.23009451
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.20885155
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.86291558
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.72902445
5	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.70030159
6	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.57681447
7	ZNF263_19887448_ChIP-Seq_K562_Human	2.43884470
8	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.30320581
9	GATA2_21666600_ChIP-Seq_HMVEC_Human	2.13668862
10	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.13044665
11	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	2.09607029
12	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.98902418
13	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.96795861
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96287913
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.95449253
16	CLOCK_20551151_ChIP-Seq_293T_Human	1.92869141
17	LXR_22292898_ChIP-Seq_THP-1_Human	1.92257519
18	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.89816907
19	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.73889073
20	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.73870506
21	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.73096376
22	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.72435141
23	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.69018829
24	RACK7_27058665_Chip-Seq_MCF-7_Human	1.68900675
25	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.62211766
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.59183995
27	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.57150667
28	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.56595946
29	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.52214335
30	SPI1_23127762_ChIP-Seq_K562_Human	1.52116469
31	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.50078799
32	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.49503422
33	GATA1_19941826_ChIP-Seq_K562_Human	1.49255919
34	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.47548314
35	SOX2_20726797_ChIP-Seq_SW620_Human	1.47201522
36	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.47031563
37	VDR_21846776_ChIP-Seq_THP-1_Human	1.46574254
38	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.46270829
39	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.44910244
40	VDR_24763502_ChIP-Seq_THP-1_Human	1.44324565
41	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.43891718
42	SCL_19346495_ChIP-Seq_HPC-7_Human	1.43603158
43	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.42740736
44	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.39685205
45	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.38224768
46	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.36979894
47	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.36862078
48	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.36214297
49	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.36210135
50	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.35670573
51	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.34331227
52	NCOR1_26117541_ChIP-Seq_K562_Human	1.33992471
53	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30726737
54	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.29974804
55	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.29731815
56	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.25378744
57	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.24186399
58	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.24121038
59	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.20284350
60	STAT1_20625510_ChIP-Seq_HELA_Human	1.20277565
61	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.20260473
62	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.20068823
63	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.19904655
64	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.18864559
65	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.18844772
66	* BCOR_27268052_Chip-Seq_Bcells_Human	1.18779230
67	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.18119291
68	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.18070758
69	* BCL6_27268052_Chip-Seq_Bcells_Human	1.17947728
70	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.17003458
71	ATF3_27146783_Chip-Seq_COLON_Human	1.16043231
72	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15386462
73	SPI1_23547873_ChIP-Seq_NB4_Human	1.15021900
74	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.13715357
75	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.13243304
76	GATA4_25053715_ChIP-Seq_YYC3_Human	1.12582001
77	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.12023265
78	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.11309081
79	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.10319103
80	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.10019721
81	* GATA2_19941826_ChIP-Seq_K562_Human	1.08836684
82	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.08443323
83	* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.08042436
84	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.06654342
85	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.06267167
86	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.05971868
87	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.05351557
88	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.05351557
89	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04801693
90	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.04009188
91	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.03818968
92	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.02376014
93	GATA6_25053715_ChIP-Seq_YYC3_Human	1.01397730
94	* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01083808
95	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00574114
96	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.00367837
97	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.00367837
98	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.00233655
99	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.00143408
100	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99813920

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005058_abnormal_lysosome_morphology	3.42703111
2	MP0009840_abnormal_foam_cell	3.06083461
3	MP0003191_abnormal_cellular_cholesterol	2.69994315
4	MP0003806_abnormal_nucleotide_metabolis	2.61995328
5	MP0008438_abnormal_cutaneous_collagen	2.57440372
6	MP0006054_spinal_hemorrhage	2.45507793
7	MP0005464_abnormal_platelet_physiology	2.38163700
8	MP0005165_increased_susceptibility_to	2.26636618
9	MP0005360_urolithiasis	2.20905880
10	MP0003075_altered_response_to	1.99131256
11	MP0002139_abnormal_hepatobiliary_system	1.91885955
12	MP0003279_aneurysm	1.84812922
13	MP0008004_abnormal_stomach_pH	1.83866022
14	MP0005451_abnormal_body_composition	1.81594365
15	MP0003436_decreased_susceptibility_to	1.81166313
16	MP0003724_increased_susceptibility_to	1.80031185
17	MP0000343_altered_response_to	1.78829321
18	MP0000465_gastrointestinal_hemorrhage	1.69694466
19	MP0010155_abnormal_intestine_physiology	1.69073099
20	MP0010368_abnormal_lymphatic_system	1.68776102
21	MP0003303_peritoneal_inflammation	1.67504850
22	MP0002148_abnormal_hypersensitivity_rea	1.64144514
23	MP0005365_abnormal_bile_salt	1.58397894
24	MP0004272_abnormal_basement_membrane	1.52651763
25	MP0003566_abnormal_cell_adhesion	1.52125967
26	MP0005166_decreased_susceptibility_to	1.49064440
27	MP0001533_abnormal_skeleton_physiology	1.48028783
28	MP0005397_hematopoietic_system_phenotyp	1.46186926
29	MP0001545_abnormal_hematopoietic_system	1.46186926
30	MP0003828_pulmonary_edema	1.44060899
31	MP0005023_abnormal_wound_healing	1.43956739
32	MP0003705_abnormal_hypodermis_morpholog	1.43617372
33	MP0009780_abnormal_chondrocyte_physiolo	1.39142678
34	MP0001835_abnormal_antigen_presentation	1.38925748
35	MP0005670_abnormal_white_adipose	1.38718811
36	MP0003172_abnormal_lysosome_physiology	1.37313874
37	MP0010234_abnormal_vibrissa_follicle	1.36456683
38	MP0006082_CNS_inflammation	1.35510886
39	MP0000013_abnormal_adipose_tissue	1.32137940
40	MP0003186_abnormal_redox_activity	1.31497370
41	MP0003950_abnormal_plasma_membrane	1.28502154
42	MP0002419_abnormal_innate_immunity	1.27917666
43	MP0002132_abnormal_respiratory_system	1.23322192
44	MP0008260_abnormal_autophagy	1.22625822
45	MP0004510_myositis	1.22020198
46	MP0009643_abnormal_urine_homeostasis	1.21604576
47	MP0005330_cardiomyopathy	1.21091130
48	MP0004858_abnormal_nervous_system	1.20961586
49	MP0000751_myopathy	1.20830126
50	MP0009278_abnormal_bone_marrow	1.20672805
51	MP0002877_abnormal_melanocyte_morpholog	1.18750867
52	MP0005025_abnormal_response_to	1.16447980
53	MP0006036_abnormal_mitochondrial_physio	1.15404358
54	MP0003300_gastrointestinal_ulcer	1.14275120
55	MP0009785_altered_susceptibility_to	1.13389552
56	MP0001666_abnormal_nutrient_absorption	1.13064590
57	MP0008469_abnormal_protein_level	1.12033871
58	MP0004782_abnormal_surfactant_physiolog	1.08858864
59	MP0000858_altered_metastatic_potential	1.06711404
60	MP0000681_abnormal_thyroid_gland	1.06691345
61	MP0004036_abnormal_muscle_relaxation	1.05662558
62	MP0008775_abnormal_heart_ventricle	1.05324736
63	MP0001958_emphysema	1.04595952
64	MP0005085_abnormal_gallbladder_physiolo	1.03629259
65	MP0000678_abnormal_parathyroid_gland	1.02988344
66	MP0004019_abnormal_vitamin_homeostasis	1.02697377
67	MP0005164_abnormal_response_to	1.01787570
68	MP0002998_abnormal_bone_remodeling	1.00524617
69	MP0001845_abnormal_inflammatory_respons	0.99976156
70	MP0005319_abnormal_enzyme/_coenzyme	0.99945735
71	MP0001873_stomach_inflammation	0.99473398
72	MP0001542_abnormal_bone_strength	0.98232618
73	MP0000249_abnormal_blood_vessel	0.98190925
74	MP0005083_abnormal_biliary_tract	0.97314891
75	MP0004084_abnormal_cardiac_muscle	0.95306247
76	MP0004147_increased_porphyrin_level	0.93857953
77	MP0004264_abnormal_extraembryonic_tissu	0.93831890
78	MP0001663_abnormal_digestive_system	0.93543685
79	MP0009764_decreased_sensitivity_to	0.92902967
80	MP0002896_abnormal_bone_mineralization	0.92774238
81	MP0010352_gastrointestinal_tract_polyps	0.90876031
82	MP0000604_amyloidosis	0.89432863
83	MP0003656_abnormal_erythrocyte_physiolo	0.89220468
84	MP0005332_abnormal_amino_acid	0.87950364
85	MP0005167_abnormal_blood-brain_barrier	0.87149450
86	MP0000747_muscle_weakness	0.87092121
87	MP0005390_skeleton_phenotype	0.86706876
88	MP0001853_heart_inflammation	0.85854554
89	MP0000003_abnormal_adipose_tissue	0.84830345
90	MP0003448_altered_tumor_morphology	0.84155087
91	MP0002118_abnormal_lipid_homeostasis	0.83487074
92	MP0005584_abnormal_enzyme/coenzyme_acti	0.83419591
93	MP0001664_abnormal_digestion	0.83313681
94	MP0005375_adipose_tissue_phenotype	0.83007338
95	MP0008875_abnormal_xenobiotic_pharmacok	0.81842255
96	MP0004947_skin_inflammation	0.81549411
97	MP0005636_abnormal_mineral_homeostasis	0.81515434
98	MP0005275_abnormal_skin_tensile	0.81292694
99	MP0001756_abnormal_urination	0.80875401
100	MP0005666_abnormal_adipose_tissue	0.80684762

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus (HP:0002725)	3.95173001
2	Abnormality of liposaccharide metabolism (HP:0010968)	3.87024124
3	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.87024124
4	Abnormality of glycolipid metabolism (HP:0010969)	3.87024124
5	Petechiae (HP:0000967)	3.36804955
6	Dysostosis multiplex (HP:0000943)	3.34428856
7	Nuclear cataract (HP:0100018)	3.18073984
8	Distal lower limb muscle weakness (HP:0009053)	3.03386252
9	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.98066018
10	Vacuolated lymphocytes (HP:0001922)	2.96167263
11	Vertebral compression fractures (HP:0002953)	2.88985249
12	Purpura (HP:0000979)	2.86550615
13	Premature rupture of membranes (HP:0001788)	2.82584990
14	Loss of speech (HP:0002371)	2.82510599
15	Abnormality of polysaccharide metabolism (HP:0011012)	2.78910677
16	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.78910677
17	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.78910677
18	Urinary glycosaminoglycan excretion (HP:0003541)	2.77772285
19	Mucopolysacchariduria (HP:0008155)	2.77772285
20	Protrusio acetabuli (HP:0003179)	2.76428667
21	Asymmetric septal hypertrophy (HP:0001670)	2.75805973
22	Amyloidosis (HP:0011034)	2.67818466
23	Malnutrition (HP:0004395)	2.66192762
24	Abnormality of the nasal mucosa (HP:0000433)	2.54372926
25	Rhabdomyolysis (HP:0003201)	2.46972950
26	Hydroxyprolinuria (HP:0003080)	2.46915448
27	Abnormality of proline metabolism (HP:0010907)	2.46915448
28	Abnormality of complement system (HP:0005339)	2.46448141
29	Axonal loss (HP:0003447)	2.42909260
30	Glomerulonephritis (HP:0000099)	2.39416299
31	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.38655724
32	Complement deficiency (HP:0004431)	2.38239724
33	Prolonged bleeding time (HP:0003010)	2.33893342
34	Increased cerebral lipofuscin (HP:0011813)	2.30869739
35	Exercise-induced myalgia (HP:0003738)	2.29659933
36	Myoglobinuria (HP:0002913)	2.21597185
37	Hypertensive crisis (HP:0100735)	2.19778869
38	Hepatosplenomegaly (HP:0001433)	2.14371080
39	Osteolytic defects of the hand bones (HP:0009699)	2.10508725
40	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.10508725
41	Distal upper limb amyotrophy (HP:0007149)	2.05390019
42	Upper limb amyotrophy (HP:0009129)	2.05390019
43	J-shaped sella turcica (HP:0002680)	2.03551547
44	Cervical subluxation (HP:0003308)	2.02166862
45	Polycythemia (HP:0001901)	2.01295296
46	Elevated erythrocyte sedimentation rate (HP:0003565)	2.01194467
47	Increased serum ferritin (HP:0003281)	1.99753108
48	Interstitial pulmonary disease (HP:0006530)	1.98549555
49	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.98221794
50	Increased connective tissue (HP:0009025)	1.96202866
51	Abnormality of macrophages (HP:0004311)	1.96169971
52	Epistaxis (HP:0000421)	1.93864077
53	Hemorrhage of the eye (HP:0011885)	1.92182726
54	Myocardial infarction (HP:0001658)	1.91432543
55	Atelectasis (HP:0100750)	1.91152405
56	Prolonged neonatal jaundice (HP:0006579)	1.90922661
57	Joint stiffness (HP:0001387)	1.90028528
58	Nasal polyposis (HP:0100582)	1.89589685
59	Aortic aneurysm (HP:0004942)	1.86645396
60	Growth hormone excess (HP:0000845)	1.85817307
61	Impaired platelet aggregation (HP:0003540)	1.85498707
62	Abnormal platelet function (HP:0011869)	1.85498707
63	Fat malabsorption (HP:0002630)	1.84341176
64	Bulbar palsy (HP:0001283)	1.83750118
65	Ileus (HP:0002595)	1.83575162
66	Progressive neurologic deterioration (HP:0002344)	1.82943806
67	Cholecystitis (HP:0001082)	1.82744117
68	Abnormal gallbladder physiology (HP:0012438)	1.82744117
69	Cerebral aneurysm (HP:0004944)	1.81580271
70	Ragged-red muscle fibers (HP:0003200)	1.81471720
71	Steatorrhea (HP:0002570)	1.81234378
72	Abnormality of skeletal muscle fiber size (HP:0012084)	1.80981121
73	Vascular calcification (HP:0004934)	1.80401204
74	Abnormality of iron homeostasis (HP:0011031)	1.79796960
75	Cardiovascular calcification (HP:0011915)	1.77631636
76	Increased CSF protein (HP:0002922)	1.77615621
77	Myopathic facies (HP:0002058)	1.76098224
78	Xanthomatosis (HP:0000991)	1.75992704
79	Type 1 muscle fiber predominance (HP:0003803)	1.74786965
80	Insulin-resistant diabetes mellitus (HP:0000831)	1.74371454
81	Increased variability in muscle fiber diameter (HP:0003557)	1.74349076
82	Polygenic inheritance (HP:0010982)	1.74081239
83	Hyperammonemia (HP:0001987)	1.73729118
84	Nemaline bodies (HP:0003798)	1.71979014
85	Stridor (HP:0010307)	1.71877349
86	Recurrent abscess formation (HP:0002722)	1.71841694
87	Fragile skin (HP:0001030)	1.70159186
88	Menorrhagia (HP:0000132)	1.69394022
89	Hand muscle atrophy (HP:0009130)	1.68633760
90	Glucose intolerance (HP:0000833)	1.68073446
91	Reduced subcutaneous adipose tissue (HP:0003758)	1.66944837
92	Stroke (HP:0001297)	1.65838122
93	Spinal rigidity (HP:0003306)	1.64626920
94	Abnormality of fatty-acid metabolism (HP:0004359)	1.64292594
95	Nausea (HP:0002018)	1.64227450
96	Right ventricular cardiomyopathy (HP:0011663)	1.63195578
97	Nephritis (HP:0000123)	1.63017773
98	Thrombocytosis (HP:0001894)	1.62770866
99	Hyperparathyroidism (HP:0000843)	1.62598172
100	Distal lower limb amyotrophy (HP:0008944)	1.62307374

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	3.80887091
2	NME2	3.74859469
3	MYLK	2.76693199
4	TESK1	2.54089148
5	IRAK3	2.52262780
6	MST1R	2.50863297
7	EPHA2	2.28602515
8	PDK2	2.15632484
9	MAP2K3	2.05894396
10	RIPK1	2.03979358
11	TGFBR2	1.95163041
12	MST4	1.90414918
13	TBK1	1.87324200
14	TESK2	1.85953065
15	SCYL2	1.82572724
16	MAPKAPK3	1.79257096
17	MAP3K3	1.65773365
18	LIMK1	1.53833877
19	TIE1	1.51220417
20	PRKG2	1.46324539
21	ZAP70	1.44239380
22	ABL2	1.43953079
23	TYK2	1.42566662
24	MAP3K12	1.42484722
25	PIM2	1.38693615
26	PAK4	1.38202825
27	LMTK2	1.35512162
28	KDR	1.31222828
29	KIT	1.27752732
30	FER	1.23994554
31	TRPM7	1.22116890
32	LRRK2	1.21680035
33	TRIB3	1.21111590
34	TTN	1.19901524
35	PBK	1.19306467
36	BCKDK	1.17970975
37	ILK	1.17555428
38	PTK2	1.11226994
39	FLT3	1.10447230
40	MAP3K11	1.09396486
41	JAK3	1.03585260
42	MAP3K1	1.01554849
43	MET	1.01250891
44	MAP2K6	1.00176487
45	MAP3K6	1.00097899
46	EPHB1	0.98390080
47	DDR2	0.97729732
48	TAOK2	0.93187800
49	RIPK4	0.92847375
50	MAP3K2	0.91579181
51	BMX	0.91279985
52	BMPR2	0.90948273
53	ACVR1B	0.90170000
54	MAP3K14	0.89319449
55	EPHB2	0.87824761
56	PDPK1	0.86777237
57	EIF2AK1	0.85309845
58	PHKG1	0.82575674
59	PHKG2	0.82575674
60	VRK2	0.79569175
61	ERBB4	0.74525669
62	PRKD2	0.74087571
63	PTK2B	0.71933204
64	SMG1	0.70322756
65	STK10	0.68289549
66	PTK6	0.66280292
67	FES	0.62597704
68	ARAF	0.62505658
69	CDC42BPA	0.60498516
70	TEC	0.59440779
71	PIK3CG	0.58888260
72	DAPK3	0.57984416
73	DAPK1	0.57884910
74	GRK7	0.57837788
75	TNK2	0.56934593
76	CSF1R	0.56641039
77	HIPK2	0.55943882
78	PAK1	0.55214193
79	CSK	0.53839324
80	MATK	0.53445393
81	PRPF4B	0.52765046
82	MAP2K2	0.51471876
83	MOS	0.51108933
84	PRKAA2	0.49720017
85	BLK	0.48277775
86	PRKD1	0.47743027
87	CAMK2G	0.47598622
88	STK16	0.47302411
89	PAK2	0.46714767
90	IKBKB	0.44734126
91	MAP3K8	0.44617922
92	PKN2	0.44052326
93	GSK3A	0.43838480
94	BTK	0.43467626
95	MAP2K1	0.42436525
96	PDGFRA	0.41139812
97	CAMK2D	0.40677824
98	NEK9	0.40096383
99	MAPK11	0.39402792
100	JAK1	0.38449823

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	3.97477736
2	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.79121417
3	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.28031664
4	Lysosome_Homo sapiens_hsa04142	2.24666937
5	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.22808724
6	Pentose phosphate pathway_Homo sapiens_hsa00030	2.19072076
7	Glutathione metabolism_Homo sapiens_hsa00480	2.18718874
8	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.15176407
9	Sulfur metabolism_Homo sapiens_hsa00920	2.12467239
10	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.03764839
11	Galactose metabolism_Homo sapiens_hsa00052	2.02298349
12	Renin-angiotensin system_Homo sapiens_hsa04614	1.93032482
13	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.91924102
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.79475968
15	Fat digestion and absorption_Homo sapiens_hsa04975	1.66328304
16	Fatty acid elongation_Homo sapiens_hsa00062	1.65795626
17	Mineral absorption_Homo sapiens_hsa04978	1.62227685
18	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.57952872
19	Asthma_Homo sapiens_hsa05310	1.56591061
20	Arginine biosynthesis_Homo sapiens_hsa00220	1.53441983
21	Pertussis_Homo sapiens_hsa05133	1.40175195
22	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.38375439
23	Protein digestion and absorption_Homo sapiens_hsa04974	1.30758705
24	Fatty acid degradation_Homo sapiens_hsa00071	1.30726573
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.29943284
26	Carbon metabolism_Homo sapiens_hsa01200	1.27420530
27	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.25065183
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.22525554
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.22193963
30	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.18511318
31	Leishmaniasis_Homo sapiens_hsa05140	1.16684454
32	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.15536428
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13909729
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.13483257
35	Complement and coagulation cascades_Homo sapiens_hsa04610	1.13254378
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11655426
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.11510978
38	Histidine metabolism_Homo sapiens_hsa00340	1.07433260
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05136237
40	Rheumatoid arthritis_Homo sapiens_hsa05323	1.05075159
41	Allograft rejection_Homo sapiens_hsa05330	1.03282603
42	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.01635283
43	Fatty acid metabolism_Homo sapiens_hsa01212	0.97427456
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96014074
45	Platelet activation_Homo sapiens_hsa04611	0.94076424
46	Phenylalanine metabolism_Homo sapiens_hsa00360	0.92935099
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.92593065
48	Vibrio cholerae infection_Homo sapiens_hsa05110	0.88075183
49	Salmonella infection_Homo sapiens_hsa05132	0.87172140
50	Peroxisome_Homo sapiens_hsa04146	0.86870220
51	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.86689587
52	Pancreatic secretion_Homo sapiens_hsa04972	0.84572603
53	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.83954129
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.83917098
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.83749865
56	Sphingolipid metabolism_Homo sapiens_hsa00600	0.83539023
57	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.83022868
58	Tyrosine metabolism_Homo sapiens_hsa00350	0.80922289
59	* Amoebiasis_Homo sapiens_hsa05146	0.80688654
60	Shigellosis_Homo sapiens_hsa05131	0.79518632
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79133517
62	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.78939907
63	Toxoplasmosis_Homo sapiens_hsa05145	0.78314761
64	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.76386788
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.76020574
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.74746004
67	Tuberculosis_Homo sapiens_hsa05152	0.74043307
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.72435192
69	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.71481584
70	Phagosome_Homo sapiens_hsa04145	0.71457747
71	Graft-versus-host disease_Homo sapiens_hsa05332	0.70232895
72	Legionellosis_Homo sapiens_hsa05134	0.69530865
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68789978
74	Osteoclast differentiation_Homo sapiens_hsa04380	0.67801630
75	Viral myocarditis_Homo sapiens_hsa05416	0.62840944
76	Insulin resistance_Homo sapiens_hsa04931	0.62794758
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62369864
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61526839
79	Tryptophan metabolism_Homo sapiens_hsa00380	0.58300928
80	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.57533755
81	Folate biosynthesis_Homo sapiens_hsa00790	0.54945057
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53205556
83	Hepatitis C_Homo sapiens_hsa05160	0.53202638
84	Influenza A_Homo sapiens_hsa05164	0.52919637
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52115039
86	ECM-receptor interaction_Homo sapiens_hsa04512	0.49773291
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.49584356
88	Prion diseases_Homo sapiens_hsa05020	0.49420780
89	Malaria_Homo sapiens_hsa05144	0.48436725
90	Retinol metabolism_Homo sapiens_hsa00830	0.47826771
91	Endocytosis_Homo sapiens_hsa04144	0.47750706
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47194918
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.45849591
94	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44877441
95	TNF signaling pathway_Homo sapiens_hsa04668	0.42816208
96	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40597436
97	Focal adhesion_Homo sapiens_hsa04510	0.40464402
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40314298
99	African trypanosomiasis_Homo sapiens_hsa05143	0.39843141
100	Sulfur relay system_Homo sapiens_hsa04122	0.39380263

SERPINB6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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