SERPINB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)8.88163566
2long-chain fatty acid biosynthetic process (GO:0042759)7.53582637
3keratinocyte differentiation (GO:0030216)7.23681274
4detection of bacterium (GO:0016045)6.78570934
5positive regulation of interleukin-8 secretion (GO:2000484)6.46069245
6keratinocyte proliferation (GO:0043616)6.39714202
7sphingoid metabolic process (GO:0046519)6.18742551
8chemical homeostasis within a tissue (GO:0048875)6.13205702
9epidermal cell differentiation (GO:0009913)6.10379278
10surfactant homeostasis (GO:0043129)5.87974193
11detection of other organism (GO:0098543)5.84183271
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.83647685
13regulation of ruffle assembly (GO:1900027)5.82449737
14hemidesmosome assembly (GO:0031581)5.62360898
15peptide cross-linking (GO:0018149)5.53581886
16positive regulation of cellular amide metabolic process (GO:0034250)5.52934341
17fatty acid elongation (GO:0030497)5.41990285
18linoleic acid metabolic process (GO:0043651)5.39428054
19positive regulation of p38MAPK cascade (GO:1900745)5.22412565
20sphingosine metabolic process (GO:0006670)5.08835462
21lipoxygenase pathway (GO:0019372)5.07547991
22bundle of His cell to Purkinje myocyte communication (GO:0086069)5.06371259
23phospholipid efflux (GO:0033700)4.89951014
24glucosamine-containing compound catabolic process (GO:1901072)4.83549288
25epidermis development (GO:0008544)4.80703264
26positive regulation of cholesterol efflux (GO:0010875)4.69764651
27phospholipid scrambling (GO:0017121)4.64576117
28skin morphogenesis (GO:0043589)4.61662814
29regulation of interleukin-8 secretion (GO:2000482)4.52470979
30diol metabolic process (GO:0034311)4.51711901
31hair cycle (GO:0042633)4.49958513
32molting cycle (GO:0042303)4.49958513
33regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.46422947
34positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.46422947
35positive regulation of cholesterol transport (GO:0032376)4.22344738
36positive regulation of sterol transport (GO:0032373)4.22344738
37cell adhesion mediated by integrin (GO:0033627)4.05774897
38hypotonic response (GO:0006971)4.05106603
39gap junction assembly (GO:0016264)3.90120708
40regulation of natural killer cell differentiation (GO:0032823)3.85490551
41regulation of phospholipase A2 activity (GO:0032429)3.85302564
42cell-substrate junction assembly (GO:0007044)3.84505363
43defense response to Gram-negative bacterium (GO:0050829)3.81102481
44intermediate filament organization (GO:0045109)3.77469999
45chronic inflammatory response (GO:0002544)3.70586051
46cyclooxygenase pathway (GO:0019371)3.67069931
47glutathione biosynthetic process (GO:0006750)3.65818083
48negative regulation of keratinocyte proliferation (GO:0010839)3.65201462
49long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.56871369
50regulation of p38MAPK cascade (GO:1900744)3.53712760
51transepithelial transport (GO:0070633)3.51181532
52ectoderm development (GO:0007398)3.49481319
53nonribosomal peptide biosynthetic process (GO:0019184)3.44140348
54interferon-gamma secretion (GO:0072643)3.43883626
55G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.42870444
56negative regulation of interferon-gamma production (GO:0032689)3.40912471
57viral transcription (GO:0019083)3.29356992
58negative regulation of stress fiber assembly (GO:0051497)3.23865273
59regulation of cholesterol efflux (GO:0010874)3.23437040
60positive regulation of humoral immune response (GO:0002922)3.21406780
61prostaglandin biosynthetic process (GO:0001516)3.20904294
62prostanoid biosynthetic process (GO:0046457)3.20904294
63hormone catabolic process (GO:0042447)3.20306161
64purinergic nucleotide receptor signaling pathway (GO:0035590)3.19861524
65regulation of hypersensitivity (GO:0002883)3.16532324
66negative regulation of interleukin-17 production (GO:0032700)3.13136612
67protein localization to endosome (GO:0036010)3.12658408
68positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.11816767
69intermediate filament cytoskeleton organization (GO:0045104)3.11474812
70positive regulation of epidermis development (GO:0045684)3.10220727
71negative regulation of lipid storage (GO:0010888)3.09873397
72translational termination (GO:0006415)3.05779837
73dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.05575952
74intermediate filament-based process (GO:0045103)3.04659670
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03700836
76regulation of protein localization to cell surface (GO:2000008)3.00788688
77eyelid development in camera-type eye (GO:0061029)2.98663134
78endocardial cushion development (GO:0003197)2.98476452
79gland morphogenesis (GO:0022612)2.98223829
80activation of MAPKKK activity (GO:0000185)2.98121314
81fatty-acyl-CoA metabolic process (GO:0035337)2.94302202
82sphingolipid biosynthetic process (GO:0030148)2.93332500
83mammary gland epithelial cell proliferation (GO:0033598)2.92792206
84endodermal cell differentiation (GO:0035987)2.92590022
85negative regulation of stem cell proliferation (GO:2000647)2.89639158
86positive regulation of mitochondrial membrane permeability (GO:0035794)2.88817526
87phosphatidylinositol acyl-chain remodeling (GO:0036149)2.87697153
88hair cell differentiation (GO:0035315)2.87631184
89cellular response to arsenic-containing substance (GO:0071243)2.87370131
90cardiac right ventricle morphogenesis (GO:0003215)2.86952488
91keratinocyte development (GO:0003334)2.85406409
92natural killer cell mediated cytotoxicity (GO:0042267)2.82078123
93natural killer cell mediated immunity (GO:0002228)2.82078123
94polarized epithelial cell differentiation (GO:0030859)2.82049501
95unsaturated fatty acid biosynthetic process (GO:0006636)2.81628479
96extracellular matrix assembly (GO:0085029)2.81609357
97positive regulation of vesicle fusion (GO:0031340)2.79911668
98negative regulation of kidney development (GO:0090185)2.78445959
99mesodermal cell differentiation (GO:0048333)2.77724596
100detection of external biotic stimulus (GO:0098581)2.77160415
101response to progesterone (GO:0032570)2.75266237
102ribosomal small subunit biogenesis (GO:0042274)2.73341273
103copper ion transport (GO:0006825)2.70653633
104negative regulation of T cell mediated immunity (GO:0002710)2.69364873
105positive regulation of T-helper 1 type immune response (GO:0002827)2.68520159
106CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.68373726
107T-helper cell differentiation (GO:0042093)2.68373726
108substrate-dependent cell migration (GO:0006929)2.67312018
109establishment of tissue polarity (GO:0007164)2.67102853
110establishment of planar polarity (GO:0001736)2.67102853
111peptidyl-proline hydroxylation (GO:0019511)2.66458259
112wound healing (GO:0042060)2.66138832
113defense response to fungus (GO:0050832)2.65127461
114regulation of T-helper 1 type immune response (GO:0002825)2.64830352
115opsonization (GO:0008228)2.64004550
116regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61895353
117decidualization (GO:0046697)2.61562942
118chondrocyte proliferation (GO:0035988)2.60911828
119regulation of chemokine secretion (GO:0090196)2.60809806
120regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60665870
121collagen fibril organization (GO:0030199)2.60029457
122long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.57854911
123phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.56453614
124positive regulation of keratinocyte differentiation (GO:0045618)2.55832702
125negative regulation of interleukin-2 production (GO:0032703)2.55471551
126neural crest cell development (GO:0014032)2.54964486
127phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.54225455
128viral life cycle (GO:0019058)2.53743568
129intestinal epithelial cell development (GO:0060576)2.53687382
130regulation of keratinocyte proliferation (GO:0010837)2.53679501
131prostanoid metabolic process (GO:0006692)2.53504353
132prostaglandin metabolic process (GO:0006693)2.53504353
133regulation of metalloenzyme activity (GO:0048552)2.51763317
134positive regulation of interleukin-6 production (GO:0032755)2.51253873
135epithelial cell proliferation (GO:0050673)2.50324705
136protein hydroxylation (GO:0018126)2.49872571
137membrane raft organization (GO:0031579)2.48704405
138positive regulation of epidermal cell differentiation (GO:0045606)2.48422429
139regulation of cellular amide metabolic process (GO:0034248)2.46764687
140kidney mesenchyme development (GO:0072074)2.46670340
141cellular response to vitamin D (GO:0071305)2.46407603
142negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.45729175
143negative regulation of acute inflammatory response (GO:0002674)2.45199900
144regulation of tight junction assembly (GO:2000810)2.41970198
145epithelium development (GO:0060429)2.41858862
146regulation of epidermis development (GO:0045682)2.41429203
147positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40024396
148antimicrobial humoral response (GO:0019730)2.39512289
149calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.39092322
150positive regulation of response to biotic stimulus (GO:0002833)2.38905587
151cellular response to vitamin (GO:0071295)2.37384058
152atrioventricular valve morphogenesis (GO:0003181)2.37220186
153very long-chain fatty acid metabolic process (GO:0000038)2.37205703
154SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.34952878
155cardiolipin metabolic process (GO:0032048)2.34949742
156peptide biosynthetic process (GO:0043043)2.33928604
157phosphatidylserine acyl-chain remodeling (GO:0036150)2.33656529
158peptide catabolic process (GO:0043171)2.33642663
159establishment of skin barrier (GO:0061436)18.6221783
160regulation of water loss via skin (GO:0033561)16.2804514
161desmosome organization (GO:0002934)12.4771972
162multicellular organismal water homeostasis (GO:0050891)10.6683415
163keratinization (GO:0031424)10.6032458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.77269849
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.24325247
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.22758993
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.94087048
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.64377195
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53254267
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.46602834
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.42050067
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.40149309
10FOXO3_23340844_ChIP-Seq_DLD1_Human2.21891373
11* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10844499
12TCF4_18268006_ChIP-ChIP_LS174T_Human2.01433314
13TP63_17297297_ChIP-ChIP_HaCaT_Human13.0476544
14ZNF263_19887448_ChIP-Seq_K562_Human1.95353505
15BRD4_25478319_ChIP-Seq_HGPS_Human1.93557540
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87106025
17JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84416762
18ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.82486283
19* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.81377065
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.81377065
21SOX2_20726797_ChIP-Seq_SW620_Human1.73437032
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72805148
23TP53_18474530_ChIP-ChIP_U2OS_Human1.71208944
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65025278
25* TP63_23658742_ChIP-Seq_EP156T_Human1.63772080
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60980909
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52169451
28CLOCK_20551151_ChIP-Seq_293T_Human1.47024291
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42989212
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42792334
31CJUN_26792858_Chip-Seq_BT549_Human1.41110561
32KLF5_25053715_ChIP-Seq_YYC3_Human1.36734655
33GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.33220253
34RXR_22108803_ChIP-Seq_LS180_Human1.31440836
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.30637699
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.29943984
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29749038
38BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29427534
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29018270
40GATA4_25053715_ChIP-Seq_YYC3_Human1.27909827
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27006104
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.26190552
43TP63_22573176_ChIP-Seq_HFKS_Human1.25180076
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.23222280
45CEBPB_22108803_ChIP-Seq_LS180_Human1.23112961
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19530791
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19191729
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18510031
49GATA6_21074721_ChIP-Seq_CACO-2_Human1.17949914
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17520219
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15346903
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.15093196
53AR_21572438_ChIP-Seq_LNCaP_Human1.13911295
54BCAT_22108803_ChIP-Seq_LS180_Human1.12906781
55GATA3_24758297_ChIP-Seq_MCF-7_Human1.12856301
56EGR1_19032775_ChIP-ChIP_M12_Human1.11837381
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08223036
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06421958
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04565311
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04481191
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03668819
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01819257
63SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99481919
64TAF15_26573619_Chip-Seq_HEK293_Human0.97911680
65SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96522085
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96172850
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95987908
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95543356
69* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95293331
70TP53_22127205_ChIP-Seq_IMR90_Human0.95275616
71RBPJ_21746931_ChIP-Seq_IB4_Human0.94758234
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94211263
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92758297
74EED_16625203_ChIP-ChIP_MESCs_Mouse0.92378386
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91052623
76AHR_22903824_ChIP-Seq_MCF-7_Human0.90836852
77SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90342309
78TP53_20018659_ChIP-ChIP_R1E_Mouse0.88877189
79TP53_16413492_ChIP-PET_HCT116_Human0.88134193
80* TCF4_22108803_ChIP-Seq_LS180_Human0.85791608
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85529314
82PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85205525
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84878197
84ATF3_27146783_Chip-Seq_COLON_Human0.84263436
85VDR_22108803_ChIP-Seq_LS180_Human0.83989529
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.83895760
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83687280
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82623905
89MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82543242
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82176810
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81811242
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81334693
93RACK7_27058665_Chip-Seq_MCF-7_Human0.80442334
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80423563
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80199559
96HNFA_21074721_ChIP-Seq_CACO-2_Human0.79796099
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.79180353
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78868366
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.78845318
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78584596
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78362137
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78079823
103CTCF_27219007_Chip-Seq_Bcells_Human0.77932401
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76864236
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76864236
106PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76656033
107EZH2_27304074_Chip-Seq_ESCs_Mouse0.76287679
108GATA6_25053715_ChIP-Seq_YYC3_Human0.75188604
109SMC1_22415368_ChIP-Seq_MEFs_Mouse0.74707945
110JARID2_20075857_ChIP-Seq_MESCs_Mouse0.74427951
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74426109
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.72874493
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.72361138
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.71035602
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.70904137
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.70365375
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.70323060
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.70281459
119RNF2_27304074_Chip-Seq_ESCs_Mouse0.69808490
120GATA3_21867929_ChIP-Seq_TH1_Mouse0.68869628
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.68147044
122CBX2_22325352_ChIP-Seq_293T-Rex_Human0.67550985
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67485102
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.67398909
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67224186
126LXR_22292898_ChIP-Seq_THP-1_Human0.67095508
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.66994736
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66496981
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.66326847
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66057528
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.66004054
132P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.64764751
133LXR_22158963_ChIP-Seq_LIVER_Mouse0.64752603
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.63515863
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.63515863
136NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.63081311
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.61997988
138CDX2_22108803_ChIP-Seq_LS180_Human0.59611285
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.56082952
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.55271208
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.55114359
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.54257082
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.54031294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.68335542
2MP0010234_abnormal_vibrissa_follicle7.26998533
3MP0003941_abnormal_skin_development6.62035850
4MP0005275_abnormal_skin_tensile5.89744327
5MP0005451_abnormal_body_composition5.43186757
6MP0005501_abnormal_skin_physiology5.20401693
7MP0004381_abnormal_hair_follicle3.87310212
8MP0008438_abnormal_cutaneous_collagen3.59005921
9MP0002060_abnormal_skin_morphology3.36467010
10MP0001216_abnormal_epidermal_layer3.18278855
11MP0010678_abnormal_skin_adnexa3.17027664
12MP0010771_integument_phenotype3.11095271
13MP0004947_skin_inflammation3.10860855
14MP0003191_abnormal_cellular_cholesterol2.81689029
15MP0004272_abnormal_basement_membrane2.63115459
16MP0002254_reproductive_system_inflammat2.55142546
17MP0003453_abnormal_keratinocyte_physiol2.38705232
18MP0000383_abnormal_hair_follicle2.35278138
19MP0002098_abnormal_vibrissa_morphology2.26157208
20MP0000647_abnormal_sebaceous_gland2.15552100
21MP0004782_abnormal_surfactant_physiolog2.10969328
22MP0000377_abnormal_hair_follicle1.85068672
23MP0004185_abnormal_adipocyte_glucose1.79490332
24MP0009931_abnormal_skin_appearance1.71867231
25MP0000579_abnormal_nail_morphology1.67646122
26MP0005257_abnormal_intraocular_pressure1.64716435
27MP0001191_abnormal_skin_condition1.62745231
28MP0005503_abnormal_tendon_morphology1.61462308
29MP0003279_aneurysm1.56800364
30MP0000467_abnormal_esophagus_morphology1.55460663
31MP0001958_emphysema1.52913551
32MP0000427_abnormal_hair_cycle1.46619940
33MP0000566_synostosis1.38785656
34MP0002009_preneoplasia1.37449137
35MP0009379_abnormal_foot_pigmentation1.28686389
36MP0003091_abnormal_cell_migration1.21841325
37MP0000762_abnormal_tongue_morphology1.21827832
38MP0003566_abnormal_cell_adhesion1.17046555
39MP0009780_abnormal_chondrocyte_physiolo1.04723112
40MP0000367_abnormal_coat/_hair1.03063553
41MP0003300_gastrointestinal_ulcer0.98806908
42MP0001346_abnormal_lacrimal_gland0.95001093
43MP0005623_abnormal_meninges_morphology0.94287956
44MP0001243_abnormal_dermal_layer0.92418333
45MP0000465_gastrointestinal_hemorrhage0.90785481
46MP0003136_yellow_coat_color0.90573220
47MP0010368_abnormal_lymphatic_system0.88886638
48MP0008961_abnormal_basal_metabolism0.88663821
49MP0003705_abnormal_hypodermis_morpholog0.87513210
50MP0003950_abnormal_plasma_membrane0.85539602
51MP0005197_abnormal_uvea_morphology0.82218264
52MP0001340_abnormal_eyelid_morphology0.82076482
53MP0001851_eye_inflammation0.81593596
54MP0002295_abnormal_pulmonary_circulatio0.79591953
55MP0005164_abnormal_response_to0.77560528
56MP0009840_abnormal_foam_cell0.71992338
57MP0008004_abnormal_stomach_pH0.71102037
58MP0003828_pulmonary_edema0.69723561
59MP0002332_abnormal_exercise_endurance0.69173593
60MP0001348_abnormal_lacrimal_gland0.68916859
61MP0001177_atelectasis0.67748434
62MP0003448_altered_tumor_morphology0.65690353
63MP0005595_abnormal_vascular_smooth0.65365634
64MP0002277_abnormal_respiratory_mucosa0.64192367
65MP0000767_abnormal_smooth_muscle0.63515024
66MP0001784_abnormal_fluid_regulation0.62934788
67MP0000733_abnormal_muscle_development0.61852173
68MP0000003_abnormal_adipose_tissue0.59994265
69MP0006054_spinal_hemorrhage0.59178240
70MP0000858_altered_metastatic_potential0.57705330
71MP0000750_abnormal_muscle_regeneration0.57115451
72MP0002090_abnormal_vision0.52541510
73MP0009384_cardiac_valve_regurgitation0.51944697
74MP0002177_abnormal_outer_ear0.50760756
75MP0005076_abnormal_cell_differentiation0.50565840
76MP0005666_abnormal_adipose_tissue0.49543671
77MP0001188_hyperpigmentation0.48968095
78MP0008260_abnormal_autophagy0.48207401
79MP0004510_myositis0.47332008
80MP0005193_abnormal_anterior_eye0.47286910
81MP0002998_abnormal_bone_remodeling0.46301372
82MP0000428_abnormal_craniofacial_morphol0.45686747
83MP0005390_skeleton_phenotype0.44789189
84MP0003329_amyloid_beta_deposits0.44718939
85MP0005187_abnormal_penis_morphology0.44712345
86MP0010030_abnormal_orbit_morphology0.43643169
87MP0002095_abnormal_skin_pigmentation0.42808741
88MP0005621_abnormal_cell_physiology0.42059743
89MP0001881_abnormal_mammary_gland0.41002538
90MP0002877_abnormal_melanocyte_morpholog0.39537037
91MP0010352_gastrointestinal_tract_polyps0.38989182
92MP0005171_absent_coat_pigmentation0.38282544
93MP0006082_CNS_inflammation0.38221443
94MP0004043_abnormal_pH_regulation0.37916577
95MP0001542_abnormal_bone_strength0.37543275
96MP0005023_abnormal_wound_healing0.36737404
97MP0005375_adipose_tissue_phenotype0.36382796
98MP0004019_abnormal_vitamin_homeostasis0.35265637
99MP0005409_darkened_coat_color0.33895957
100MP0002166_altered_tumor_susceptibility0.33304619
101MP0002132_abnormal_respiratory_system0.32321873
102MP0001984_abnormal_olfaction0.31875994
103MP0000627_abnormal_mammary_gland0.30623842
104MP0003638_abnormal_response/metabolism_0.29645712
105MP0009672_abnormal_birth_weight0.29518620
106MP0000013_abnormal_adipose_tissue0.29495390
107MP0002234_abnormal_pharynx_morphology0.29238550
108MP0001299_abnormal_eye_distance/0.28773618
109MP0002006_tumorigenesis0.27346601
110MP0005075_abnormal_melanosome_morpholog0.27145591
111MP0010386_abnormal_urinary_bladder0.26852019
112MP0002111_abnormal_tail_morphology0.26296390
113MP0002249_abnormal_larynx_morphology0.25090694
114MP0002282_abnormal_trachea_morphology0.23195264
115MP0003763_abnormal_thymus_physiology0.22825295
116MP0002896_abnormal_bone_mineralization0.21596170
117MP0005647_abnormal_sex_gland0.21259274
118MP0000470_abnormal_stomach_morphology0.21236213
119MP0005508_abnormal_skeleton_morphology0.21021339
120MP0003938_abnormal_ear_development0.20701538
121MP0002876_abnormal_thyroid_physiology0.20663226
122MP0002233_abnormal_nose_morphology0.19804350
123MP0000538_abnormal_urinary_bladder0.19728565
124MP0000432_abnormal_head_morphology0.19620831
125MP0003755_abnormal_palate_morphology0.18841639
126MP0001849_ear_inflammation0.18035090
127MP0004264_abnormal_extraembryonic_tissu0.17709704
128MP0002148_abnormal_hypersensitivity_rea0.17524780
129MP0003436_decreased_susceptibility_to0.17378195
130MP0005388_respiratory_system_phenotype0.17138131
131MP0002133_abnormal_respiratory_system0.17138131
132MP0005367_renal/urinary_system_phenotyp0.15325460
133MP0000516_abnormal_urinary_system0.15325460
134MP0003011_delayed_dark_adaptation0.15234883
135MP0008875_abnormal_xenobiotic_pharmacok0.14718602
136MP0003195_calcinosis0.14542380
137MP0002971_abnormal_brown_adipose0.14187934
138MP0009053_abnormal_anal_canal0.13814727

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.96213263
2Hypotrichosis (HP:0001006)6.23897704
3Gangrene (HP:0100758)6.08427578
4Erythroderma (HP:0001019)5.92977171
5Ectropion (HP:0000656)5.90668118
6Parakeratosis (HP:0001036)5.85240696
7Abnormality of nail color (HP:0100643)5.78409058
8Follicular hyperkeratosis (HP:0007502)5.56073924
9Right ventricular cardiomyopathy (HP:0011663)5.55347089
10Lip pit (HP:0100267)5.49809320
11Erythema (HP:0010783)5.16544522
12Onycholysis (HP:0001806)5.11416171
13Corneal erosion (HP:0200020)5.08176643
14Plantar hyperkeratosis (HP:0007556)4.92581332
15Woolly hair (HP:0002224)4.85188489
16Palmoplantar hyperkeratosis (HP:0000972)4.60594711
17Fragile nails (HP:0001808)4.58989357
18Hypohidrosis (HP:0000966)4.57160019
19Hyporeflexia of lower limbs (HP:0002600)4.53542094
20Oral leukoplakia (HP:0002745)4.44987621
21Palmar hyperkeratosis (HP:0010765)4.33108275
22Pruritus (HP:0000989)4.28817101
23Lack of skin elasticity (HP:0100679)3.89812206
24Curly hair (HP:0002212)3.83431633
25Eczematoid dermatitis (HP:0000976)3.71734895
26Premature rupture of membranes (HP:0001788)3.68798804
27Sparse scalp hair (HP:0002209)3.58620808
28Dehydration (HP:0001944)3.46836015
29Distal lower limb muscle weakness (HP:0009053)3.46493449
30Milia (HP:0001056)3.42317097
31Acanthosis nigricans (HP:0000956)3.34580266
32Areflexia of lower limbs (HP:0002522)3.27501442
33Malignant hyperthermia (HP:0002047)3.24412452
34Protrusio acetabuli (HP:0003179)3.11052547
35Abnormal blistering of the skin (HP:0008066)3.10371866
36Fragile skin (HP:0001030)3.07429121
37Concave nail (HP:0001598)3.05149655
38Dry skin (HP:0000958)3.02303359
39Natal tooth (HP:0000695)2.99689540
40* Palmoplantar keratoderma (HP:0000982)2.98042852
41Nail dystrophy (HP:0008404)2.95030399
42Premature ovarian failure (HP:0008209)2.86539976
43Popliteal pterygium (HP:0009756)2.80412961
44Conjunctival hamartoma (HP:0100780)2.76701660
45Ventricular tachycardia (HP:0004756)2.73730892
46Vascular tortuosity (HP:0004948)2.69912516
47Dry hair (HP:0011359)2.67952458
48Hypergammaglobulinemia (HP:0010702)2.65361752
49Abnormality of the salivary glands (HP:0010286)2.63165052
50Abnormality of small intestinal villus morphology (HP:0011472)2.62198196
51Villous atrophy (HP:0011473)2.62198196
52Sepsis (HP:0100806)2.59544107
53Brittle hair (HP:0002299)2.59169230
54Abnormality of the axillary hair (HP:0100134)2.59151082
55Abnormality of secondary sexual hair (HP:0009888)2.59151082
56Advanced eruption of teeth (HP:0006288)2.59017866
57Sparse eyelashes (HP:0000653)2.58777607
58Thick nail (HP:0001805)2.56656153
59Neonatal short-limb short stature (HP:0008921)2.55681145
60Arterial tortuosity (HP:0005116)2.53435124
61Paralysis (HP:0003470)2.51670201
62Sensory axonal neuropathy (HP:0003390)2.43836350
63Laryngomalacia (HP:0001601)2.42648958
64Cardiovascular calcification (HP:0011915)2.41338182
65Aortic dissection (HP:0002647)2.37554169
66* Hyperhidrosis (HP:0000975)2.32354753
67Selective tooth agenesis (HP:0001592)2.31298378
68Aortic aneurysm (HP:0004942)2.27594547
69Hypoplastic labia majora (HP:0000059)2.27194678
70Anhidrosis (HP:0000970)2.25667869
71Oligodontia (HP:0000677)2.23163932
72Corneal dystrophy (HP:0001131)2.20218499
73Absent eyelashes (HP:0000561)2.18121727
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15782230
75Pili torti (HP:0003777)2.12123689
76Pustule (HP:0200039)2.10312975
77Severe Myopia (HP:0011003)2.08639287
78Vascular calcification (HP:0004934)2.07604079
79Abnormality of the labia majora (HP:0012881)2.06941803
80Soft skin (HP:0000977)2.03748651
81Atrophic scars (HP:0001075)2.00733473
82Congenital ichthyosiform erythroderma (HP:0007431)10.6174650
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)10.3326155
84Chronic bronchitis (HP:0004469)1.99794141
85Conical tooth (HP:0000698)1.99624816
86Ridged nail (HP:0001807)1.97768521
87Short nail (HP:0001799)1.97640990
88Cervical subluxation (HP:0003308)1.96623877
89Bladder diverticulum (HP:0000015)1.95595180
90Abnormal hemoglobin (HP:0011902)1.94890307
91Everted lower lip vermilion (HP:0000232)1.94839854
92Ankle contracture (HP:0006466)1.93635245
93Amniotic constriction ring (HP:0009775)1.93441852
94Abnormality of placental membranes (HP:0011409)1.93441852
95Tetraparesis (HP:0002273)1.90942998
96Urticaria (HP:0001025)1.89857892
97Wormian bones (HP:0002645)1.88948925
98Congenital, generalized hypertrichosis (HP:0004540)1.87670809
99Elbow flexion contracture (HP:0002987)1.87301715
100Reduced subcutaneous adipose tissue (HP:0003758)1.86952349
101Hypoplasia of dental enamel (HP:0006297)1.86516611
102Osteolytic defects of the phalanges of the hand (HP:0009771)1.86022024
103Osteolytic defects of the hand bones (HP:0009699)1.86022024
104Abnormality of the gastric mucosa (HP:0004295)1.85975721
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85478379
106Ventricular fibrillation (HP:0001663)1.81951256
107Alopecia of scalp (HP:0002293)1.80980815
108Asthma (HP:0002099)1.79244029
109Dilatation of the ascending aorta (HP:0005111)1.78644274
110Short middle phalanx of the 5th finger (HP:0004220)1.78106766
111Carious teeth (HP:0000670)1.76108367
112Anonychia (HP:0001798)1.75987710
113Spinal rigidity (HP:0003306)1.71649704
114Pterygium (HP:0001059)1.71523482
115Abnormality of the neuromuscular junction (HP:0003398)1.69998470
116Fatigable weakness (HP:0003473)1.69998470
117Entropion (HP:0000621)1.69483936
118Type 1 muscle fiber predominance (HP:0003803)1.68733719
119Ulnar claw (HP:0001178)1.68507485
120Septate vagina (HP:0001153)1.67458120
121Type I diabetes mellitus (HP:0100651)1.66806543
122Mildly elevated creatine phosphokinase (HP:0008180)1.66702364
123Spondylolisthesis (HP:0003302)1.66491700
124Hamartoma of the eye (HP:0010568)1.65702141
125Stenosis of the external auditory canal (HP:0000402)1.64573869
126Xerostomia (HP:0000217)1.63667338
127Abnormal hair laboratory examination (HP:0003328)1.63263159
128Achilles tendon contracture (HP:0001771)1.62617590
129Abnormality of cells of the erythroid lineage (HP:0012130)1.62390744
130Knee flexion contracture (HP:0006380)1.61787839
131Vertebral compression fractures (HP:0002953)1.61439801
132Mitral stenosis (HP:0001718)1.60127885
133Ankyloglossia (HP:0010296)1.59479810
134Humeroradial synostosis (HP:0003041)1.59247295
135Synostosis involving the elbow (HP:0003938)1.59247295
136Blepharitis (HP:0000498)1.59174651
137Coronal craniosynostosis (HP:0004440)1.57038123
138Abnormality of the fingernails (HP:0001231)1.55604341
139Spinal cord lesions (HP:0100561)1.55153967
140Steppage gait (HP:0003376)1.53154346
141Abnormality of the Achilles tendon (HP:0005109)1.51922184
142Hydroxyprolinuria (HP:0003080)1.50354994
143Abnormality of proline metabolism (HP:0010907)1.50354994
144Skin pits (HP:0100276)1.49790759
145Hypodontia (HP:0000668)1.49540006
146Absent eyebrow (HP:0002223)1.42231656
147Emphysema (HP:0002097)1.41850157
148Reticulocytopenia (HP:0001896)1.41831529
149Skin rash (HP:0000988)1.41558389
150Bifid scrotum (HP:0000048)1.39941605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK35.77152102
2MST45.27152368
3LMTK23.87811088
4MAP3K23.60534757
5MST1R3.43217376
6AKT33.26656576
7MAP3K33.15394789
8MYLK2.75499347
9RPS6KB22.63710467
10FER2.62043946
11MOS2.12586670
12PDGFRA2.00162699
13MAPKAPK51.93513964
14FGFR11.88951532
15MAP3K91.88066995
16BMPR21.85614769
17TRPM71.82132870
18ERBB31.77642365
19STK101.76427694
20MAP3K141.75956597
21DDR21.75234588
22STK241.72228913
23PIM21.62535720
24LATS11.61950159
25LRRK21.60414528
26MAP3K121.53767721
27SRPK11.53262784
28ARAF1.48249149
29TGFBR11.47637110
30PAK41.45253331
31RIPK11.41913427
32PAK21.41228523
33BCR1.39364345
34TESK11.38655626
35EPHA31.36496787
36DYRK1B1.36097371
37FLT31.35930052
38ABL21.35559918
39MAP3K111.35028881
40IRAK31.32177956
41GRK51.30234332
42PTK61.26290970
43PDGFRB1.23507190
44STK381.23004249
45NTRK11.20430185
46MAP3K71.19794649
47MAP3K131.14685455
48NEK91.13485584
49PIK3CG1.12742159
50ERN11.11314116
51MAP3K61.09888766
52PAK31.09301215
53BMPR1B1.08271728
54ITK1.07499480
55WNK11.06566896
56BLK1.04911536
57EPHA21.00879455
58MAP3K10.99826815
59EPHB20.99817981
60FGR0.96069140
61EPHB10.95840219
62FGFR40.93206270
63PBK0.92765023
64PRKD20.91378268
65MAP2K60.88131273
66MAPKAPK20.83194900
67MARK20.81502220
68TAOK20.80472610
69LATS20.79673759
70IKBKB0.79464846
71SYK0.78810451
72EPHA40.77385700
73GSK3A0.74529594
74NTRK20.73690437
75DMPK0.73251050
76HIPK20.72771916
77GRK70.72728811
78MET0.71757823
79PRKG20.71300616
80MAP2K40.70045969
81MAPK70.67265538
82CDK60.66100719
83ADRBK10.65625500
84CSNK1D0.64141957
85ICK0.63954255
86MTOR0.63679378
87ROCK10.62910129
88PRKD10.62711292
89PTK2B0.62101308
90EIF2AK20.62090668
91DYRK30.58438228
92LIMK10.58359671
93TYRO30.58156981
94CASK0.57365528
95MAP2K10.55472883
96GRK10.55447466
97PKN10.55023153
98TTN0.53638378
99IKBKE0.53331540
100TYK20.53000559
101PRKCE0.51422805
102TAOK10.50207547
103AURKA0.49606466
104BMX0.47462592
105FGFR30.46918220
106STK38L0.46791804
107TGFBR20.46371273
108STK110.45320901
109IRAK20.45156132
110CHUK0.45132569
111FGFR20.44835588
112SIK10.44786666
113MAP3K50.44683929
114MAP2K20.43815165
115EIF2AK30.43463625
116PRPF4B0.42757901
117EEF2K0.42463160
118ROCK20.41797009
119ERBB40.40484913
120RPS6KL10.40456985
121RPS6KC10.40456985
122BRAF0.40059706
123PRKCI0.39969550
124MUSK0.39712953
125CDC42BPA0.39606267
126FRK0.38908497
127ILK0.38603965
128STK30.37695931
129MAPK150.36546671
130DAPK30.36233153
131JAK10.35779261
132NME20.35335818
133RPS6KA10.35126929
134RPS6KA20.34807687
135IRAK10.34792750
136PTK20.34755954
137SIK30.34015967
138TBK10.33922600
139ABL10.33738056
140MAP2K30.33073946
141IRAK40.27592032
142SGK4940.23794624
143SGK2230.23794624
144CDK120.23744460
145SGK30.23296412
146CAMK2G0.20340460

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.90222118
2Sphingolipid metabolism_Homo sapiens_hsa006004.24853759
3Arachidonic acid metabolism_Homo sapiens_hsa005903.09348070
4Fatty acid elongation_Homo sapiens_hsa000623.08665199
5Linoleic acid metabolism_Homo sapiens_hsa005912.99325193
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.93969968
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86235635
8ABC transporters_Homo sapiens_hsa020102.68946502
9Ribosome_Homo sapiens_hsa030102.66434284
10Histidine metabolism_Homo sapiens_hsa003402.29278614
11Focal adhesion_Homo sapiens_hsa045102.10020128
12Ether lipid metabolism_Homo sapiens_hsa005652.00204324
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87536441
14Tight junction_Homo sapiens_hsa045301.80631204
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72375438
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66335966
17Retinol metabolism_Homo sapiens_hsa008301.65802393
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64480568
19Glutathione metabolism_Homo sapiens_hsa004801.61828409
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60680054
21Small cell lung cancer_Homo sapiens_hsa052221.50370682
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44361224
23Chemical carcinogenesis_Homo sapiens_hsa052041.42440257
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39870384
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39850815
26Phenylalanine metabolism_Homo sapiens_hsa003601.33323745
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27066552
28Adherens junction_Homo sapiens_hsa045201.26759531
29Axon guidance_Homo sapiens_hsa043601.23233981
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22966152
31Shigellosis_Homo sapiens_hsa051311.22261444
32Collecting duct acid secretion_Homo sapiens_hsa049661.17401277
33Dorso-ventral axis formation_Homo sapiens_hsa043201.17013237
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16213647
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16139461
36Prion diseases_Homo sapiens_hsa050201.11944465
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.11775895
38Protein digestion and absorption_Homo sapiens_hsa049741.10669247
39VEGF signaling pathway_Homo sapiens_hsa043701.10084703
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07139842
41Sulfur metabolism_Homo sapiens_hsa009201.04556180
42Serotonergic synapse_Homo sapiens_hsa047261.03333762
43Staphylococcus aureus infection_Homo sapiens_hsa051501.03237917
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00395860
45Basal cell carcinoma_Homo sapiens_hsa052170.96382035
46Renin secretion_Homo sapiens_hsa049240.96110901
47ErbB signaling pathway_Homo sapiens_hsa040120.94707713
48Circadian rhythm_Homo sapiens_hsa047100.94428451
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94428179
50Pathways in cancer_Homo sapiens_hsa052000.92688615
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.91817634
52GnRH signaling pathway_Homo sapiens_hsa049120.88828104
53Renal cell carcinoma_Homo sapiens_hsa052110.88742330
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87846970
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86542538
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.84900035
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84706483
58p53 signaling pathway_Homo sapiens_hsa041150.84681388
59Pertussis_Homo sapiens_hsa051330.83410456
60Fat digestion and absorption_Homo sapiens_hsa049750.80782110
61Thyroid cancer_Homo sapiens_hsa052160.80697164
62Hepatitis C_Homo sapiens_hsa051600.79871921
63Hippo signaling pathway_Homo sapiens_hsa043900.77363154
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76096741
65Rheumatoid arthritis_Homo sapiens_hsa053230.76026683
66Pancreatic cancer_Homo sapiens_hsa052120.75095888
67Influenza A_Homo sapiens_hsa051640.74218835
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73335073
69Amoebiasis_Homo sapiens_hsa051460.73263727
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73027926
71Fatty acid biosynthesis_Homo sapiens_hsa000610.72299745
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72058671
73Melanogenesis_Homo sapiens_hsa049160.71764541
74FoxO signaling pathway_Homo sapiens_hsa040680.70643146
75Gastric acid secretion_Homo sapiens_hsa049710.70606111
76Chronic myeloid leukemia_Homo sapiens_hsa052200.70420730
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69582046
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68481593
79Pancreatic secretion_Homo sapiens_hsa049720.68092170
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67630290
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.67111166
82Dilated cardiomyopathy_Homo sapiens_hsa054140.66698031
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66674621
84Mineral absorption_Homo sapiens_hsa049780.65780837
85Apoptosis_Homo sapiens_hsa042100.64120887
86Tyrosine metabolism_Homo sapiens_hsa003500.62363103
87Glioma_Homo sapiens_hsa052140.62004218
88Ras signaling pathway_Homo sapiens_hsa040140.62003242
89Proteoglycans in cancer_Homo sapiens_hsa052050.61773682
90African trypanosomiasis_Homo sapiens_hsa051430.61247881
91Long-term potentiation_Homo sapiens_hsa047200.60182463
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.58871683
93TNF signaling pathway_Homo sapiens_hsa046680.57453252
94Prostate cancer_Homo sapiens_hsa052150.57119122
95Lysosome_Homo sapiens_hsa041420.56285706
96ECM-receptor interaction_Homo sapiens_hsa045120.55222884
97Choline metabolism in cancer_Homo sapiens_hsa052310.54832931
98Long-term depression_Homo sapiens_hsa047300.53885238
99Phototransduction_Homo sapiens_hsa047440.53495052
100Bladder cancer_Homo sapiens_hsa052190.53205199
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.52714019
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.52367125
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.50810409
104Toxoplasmosis_Homo sapiens_hsa051450.50554879
105Ovarian steroidogenesis_Homo sapiens_hsa049130.50366212
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50289112
107Platelet activation_Homo sapiens_hsa046110.49902112
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.49807585
109MicroRNAs in cancer_Homo sapiens_hsa052060.49791926
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.48742844
111HIF-1 signaling pathway_Homo sapiens_hsa040660.47001298
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46650595
113Other glycan degradation_Homo sapiens_hsa005110.44751308
114Hepatitis B_Homo sapiens_hsa051610.44624435
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44383493
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44318608
117Fatty acid degradation_Homo sapiens_hsa000710.44050878
118Inositol phosphate metabolism_Homo sapiens_hsa005620.43893204
119Malaria_Homo sapiens_hsa051440.43479807
120Measles_Homo sapiens_hsa051620.43358289
121Endocytosis_Homo sapiens_hsa041440.41813705
122MAPK signaling pathway_Homo sapiens_hsa040100.41646735
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.41114345
124beta-Alanine metabolism_Homo sapiens_hsa004100.40042004
125Rap1 signaling pathway_Homo sapiens_hsa040150.37194695
126Fatty acid metabolism_Homo sapiens_hsa012120.35719875
127Glycerolipid metabolism_Homo sapiens_hsa005610.35439266
128Oxytocin signaling pathway_Homo sapiens_hsa049210.35137539
129Tuberculosis_Homo sapiens_hsa051520.34989886
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34915954
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34616190
132Wnt signaling pathway_Homo sapiens_hsa043100.33507158
133TGF-beta signaling pathway_Homo sapiens_hsa043500.33426277
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33296764
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.33225613
136Legionellosis_Homo sapiens_hsa051340.32921770
137Insulin resistance_Homo sapiens_hsa049310.30846629
138Hedgehog signaling pathway_Homo sapiens_hsa043400.30067495
139Melanoma_Homo sapiens_hsa052180.29491976
140T cell receptor signaling pathway_Homo sapiens_hsa046600.29052425
141Complement and coagulation cascades_Homo sapiens_hsa046100.28486567
142Phagosome_Homo sapiens_hsa041450.27480943
143Vibrio cholerae infection_Homo sapiens_hsa051100.27098869
144Salmonella infection_Homo sapiens_hsa051320.26221661
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26197166
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25379596

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »