SERPINB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)7.85157296
2regulation of water loss via skin (GO:0033561)6.92650206
3desmosome organization (GO:0002934)6.70185519
4hemidesmosome assembly (GO:0031581)5.01683030
5keratinization (GO:0031424)4.98733499
6water homeostasis (GO:0030104)4.53756827
7multicellular organismal water homeostasis (GO:0050891)4.52803661
8negative regulation of interleukin-12 production (GO:0032695)4.41825653
9detection of other organism (GO:0098543)4.41293339
10detection of bacterium (GO:0016045)4.34268026
11regulation of vitamin D biosynthetic process (GO:0060556)3.89307320
12keratinocyte differentiation (GO:0030216)3.88668827
13lipopolysaccharide-mediated signaling pathway (GO:0031663)3.88488080
14positive regulation of monocyte chemotaxis (GO:0090026)3.81711039
15cellular extravasation (GO:0045123)3.79784429
16peptide cross-linking (GO:0018149)3.75848615
17keratinocyte proliferation (GO:0043616)3.72224865
18positive regulation of gamma-delta T cell activation (GO:0046645)3.70856523
19detection of biotic stimulus (GO:0009595)3.68996484
20positive regulation of chemokine biosynthetic process (GO:0045080)3.66800799
21detection of external biotic stimulus (GO:0098581)3.64230845
22positive regulation of cholesterol efflux (GO:0010875)3.61833441
23phospholipid efflux (GO:0033700)3.61607815
24lipoxygenase pathway (GO:0019372)3.60820379
25immunoglobulin mediated immune response (GO:0016064)3.58894378
26regulation of chemokine biosynthetic process (GO:0045073)3.54717097
27regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48345556
28positive regulation by symbiont of host defense response (GO:0052509)3.42666128
29modulation by symbiont of host defense response (GO:0052031)3.42666128
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.42666128
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.42666128
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.42666128
33modulation by symbiont of host immune response (GO:0052553)3.42666128
34regulation of cell proliferation involved in kidney development (GO:1901722)3.40913741
35regulation of phospholipase A2 activity (GO:0032429)3.32860496
36G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.32733529
37positive regulation of Cdc42 GTPase activity (GO:0043089)3.31501151
38positive regulation of cellular amide metabolic process (GO:0034250)3.28025528
39germinal center formation (GO:0002467)3.25363100
40regulation of monocyte chemotaxis (GO:0090025)3.24813789
41positive regulation of antigen processing and presentation (GO:0002579)3.24024519
42detection of molecule of bacterial origin (GO:0032490)3.19692207
43protein localization to endosome (GO:0036010)3.19419719
44positive regulation of sterol transport (GO:0032373)3.19395224
45positive regulation of cholesterol transport (GO:0032376)3.19395224
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18100900
47neutrophil mediated immunity (GO:0002446)3.14952194
48NIK/NF-kappaB signaling (GO:0038061)3.12680141
49regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10428094
50granulocyte activation (GO:0036230)3.09875621
51regulation of interleukin-8 secretion (GO:2000482)3.05836933
52interferon-gamma-mediated signaling pathway (GO:0060333)3.05258669
53regulation of T-helper 2 cell differentiation (GO:0045628)3.04661114
54regulation of interferon-beta biosynthetic process (GO:0045357)3.03627041
55regulation of vitamin metabolic process (GO:0030656)3.02732342
56surfactant homeostasis (GO:0043129)2.99461893
57bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98473014
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.96608059
59regulation of mast cell degranulation (GO:0043304)2.96424623
60membrane raft organization (GO:0031579)2.94681507
61hair cycle (GO:0042633)2.94204405
62molting cycle (GO:0042303)2.94204405
63positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.93361744
64regulation of integrin activation (GO:0033623)2.92014688
65T-helper 1 type immune response (GO:0042088)2.92007352
66myeloid cell activation involved in immune response (GO:0002275)2.91693633
67epidermal cell differentiation (GO:0009913)2.91330575
68chemical homeostasis within a tissue (GO:0048875)2.90858526
69regulation of T-helper 1 cell differentiation (GO:0045625)2.87466703
70negative regulation of cell killing (GO:0031342)2.86519685
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86519685
72regulation of podosome assembly (GO:0071801)2.86187590
73regulation of transforming growth factor beta1 production (GO:0032908)2.84840950
74positive regulation of type 2 immune response (GO:0002830)2.82830295
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82717468
76neutrophil activation (GO:0042119)2.81988138
77regulation of interferon-alpha production (GO:0032647)2.79276586
78defense response to protozoan (GO:0042832)2.79057339
79positive regulation of interleukin-6 production (GO:0032755)2.78891540
80type I interferon signaling pathway (GO:0060337)2.78772866
81cellular response to type I interferon (GO:0071357)2.78772866
82regulation of antigen processing and presentation (GO:0002577)2.78594845
83regulation of natural killer cell differentiation (GO:0032823)2.78417879
84response to protozoan (GO:0001562)2.78190615
85sphingosine metabolic process (GO:0006670)2.77898962
86superoxide anion generation (GO:0042554)2.77788396
87myeloid dendritic cell differentiation (GO:0043011)2.77102442
88regulation of leukocyte degranulation (GO:0043300)2.75872308
89regulation of mast cell activation involved in immune response (GO:0033006)2.74521945
90positive regulation of mast cell activation (GO:0033005)2.74446372
91response to type I interferon (GO:0034340)2.74155924
92negative regulation of nitric oxide biosynthetic process (GO:0045019)2.73221804
93mature B cell differentiation involved in immune response (GO:0002313)2.71803236
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71370969
95negative regulation of growth of symbiont in host (GO:0044130)2.70667259
96negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.70667259
97modulation of growth of symbiont involved in interaction with host (GO:0044144)2.70667259
98regulation of growth of symbiont in host (GO:0044126)2.70667259
99positive regulation of leukocyte degranulation (GO:0043302)2.70341323
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69920956
101glycosphingolipid catabolic process (GO:0046479)2.68712762
102leukocyte aggregation (GO:0070486)2.68612273
103B cell mediated immunity (GO:0019724)2.68185887
104positive regulation of interleukin-1 beta secretion (GO:0050718)2.67838083
105negative regulation of interleukin-17 production (GO:0032700)2.66351544
106positive regulation of interferon-alpha production (GO:0032727)2.65792652
107negative regulation of cytokine production involved in immune response (GO:0002719)2.65617933
108neutrophil activation involved in immune response (GO:0002283)2.65146246
109antigen processing and presentation of endogenous antigen (GO:0019883)2.64034927
110long-chain fatty acid biosynthetic process (GO:0042759)2.63478665
111positive regulation of glomerulus development (GO:0090193)2.62290099
112positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62177386
113regulation of interleukin-6 production (GO:0032675)2.62140747
114regulation of type 2 immune response (GO:0002828)2.61294797
115myeloid dendritic cell activation (GO:0001773)2.61027983
116regulation of mast cell activation (GO:0033003)2.60855636
117regulation of T cell tolerance induction (GO:0002664)2.60249903
118cellular response to lipopolysaccharide (GO:0071222)2.59706473
119hydrogen peroxide biosynthetic process (GO:0050665)2.58671406
120regulation of tolerance induction (GO:0002643)2.58031889
121dendritic cell migration (GO:0036336)2.56620853
122cellular response to molecule of bacterial origin (GO:0071219)2.55721864
123sphingoid metabolic process (GO:0046519)2.55656996
124positive regulation of mast cell activation involved in immune response (GO:0033008)2.55427707
125positive regulation of mast cell degranulation (GO:0043306)2.55427707
126microglial cell activation (GO:0001774)2.54791960
127cellular response to thyroid hormone stimulus (GO:0097067)2.54544601
128macrophage activation involved in immune response (GO:0002281)2.54528255
129epidermis development (GO:0008544)2.54196721
130positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54150118
131regulation of B cell receptor signaling pathway (GO:0050855)2.53756202
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53631846
133positive regulation of odontogenesis (GO:0042482)2.53341186
134eosinophil chemotaxis (GO:0048245)2.52522123
135response to host immune response (GO:0052572)2.52460697
136purinergic nucleotide receptor signaling pathway (GO:0035590)2.51800140
137glucosamine-containing compound catabolic process (GO:1901072)2.51294161
138regulation of mononuclear cell migration (GO:0071675)2.50380133
139regulation of hypersensitivity (GO:0002883)2.49453337
140positive regulation of T-helper 1 type immune response (GO:0002827)2.48919127
141positive regulation of interleukin-1 secretion (GO:0050716)2.48173564
142positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.47013461
143positive regulation of granulocyte chemotaxis (GO:0071624)2.46382168
144positive regulation of hair cycle (GO:0042635)2.45415901
145positive regulation of hair follicle development (GO:0051798)2.45415901
146keratinocyte development (GO:0003334)2.44507361
147monocyte chemotaxis (GO:0002548)2.40596842
148response to peptidoglycan (GO:0032494)2.40465770
149pinocytosis (GO:0006907)2.39983052
150skin morphogenesis (GO:0043589)2.39230188
151eosinophil migration (GO:0072677)2.39142384
152regulation of hair follicle development (GO:0051797)2.37415515
153regulation of heterotypic cell-cell adhesion (GO:0034114)2.37326620
154fibrinolysis (GO:0042730)2.36838446
155regulation of interleukin-1 beta secretion (GO:0050706)2.36783282
156positive regulation of lymphocyte migration (GO:2000403)2.35099895
157diol metabolic process (GO:0034311)2.32877338
158positive regulation of T cell migration (GO:2000406)2.31434263
159positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.30157453
160cyclooxygenase pathway (GO:0019371)2.29633131
161regulation of cholesterol efflux (GO:0010874)2.27583993
162pericardium development (GO:0060039)2.27074595
163positive regulation of interleukin-8 secretion (GO:2000484)2.26473567
164positive regulation of interleukin-1 beta production (GO:0032731)2.26008263
165regulation of interleukin-1 secretion (GO:0050704)2.25687770
166positive regulation of chemokine secretion (GO:0090197)2.25624794
167respiratory burst (GO:0045730)2.23952427
168negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.23277797
169regulation of Cdc42 GTPase activity (GO:0043088)2.23140640
170macrophage activation (GO:0042116)2.22971651
171regulation of interleukin-8 biosynthetic process (GO:0045414)2.22680494
172response to muramyl dipeptide (GO:0032495)2.22625392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.76497970
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.02398751
3* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.01144639
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94504360
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.78775545
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.46538228
7VDR_24763502_ChIP-Seq_THP-1_Human2.44683193
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.41306208
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.36310769
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35365653
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.35026872
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31168163
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28418302
14VDR_21846776_ChIP-Seq_THP-1_Human2.24105678
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15156981
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14811081
17SPI1_23547873_ChIP-Seq_NB4_Human2.13928822
18* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.12423271
19P63_26484246_Chip-Seq_KERATINOCYTES_Human2.01978403
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.99314802
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94533849
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93377597
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89027165
24SPI1_23127762_ChIP-Seq_K562_Human1.85584021
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85456033
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81044645
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.80716198
28* IRF8_27001747_Chip-Seq_BMDM_Mouse1.80173917
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71264609
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.70662789
31TP53_18474530_ChIP-ChIP_U2OS_Human1.69801883
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69498999
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68812361
34CJUN_26792858_Chip-Seq_BT549_Human1.65804279
35* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65733447
36RUNX_20019798_ChIP-Seq_JUKART_Human1.65111656
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65088514
38MYB_26560356_Chip-Seq_TH2_Human1.63530257
39MAF_26560356_Chip-Seq_TH1_Human1.63408794
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.60470919
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56351230
42* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55986726
43* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55986726
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.52082786
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51924352
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51537940
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51087601
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51087601
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49827679
50* SOX2_20726797_ChIP-Seq_SW620_Human1.47592504
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46022666
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45157520
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44260931
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43952277
55RXR_22108803_ChIP-Seq_LS180_Human1.43775131
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43021213
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42924607
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38930294
59MYB_26560356_Chip-Seq_TH1_Human1.38690851
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.37724406
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35540406
62SCL_19346495_ChIP-Seq_HPC-7_Human1.34898048
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.34543067
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30230674
65TP63_23658742_ChIP-Seq_EP156T_Human1.29966817
66UTX_26944678_Chip-Seq_JUKART_Human1.29857397
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29352240
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29224675
69VDR_24787735_ChIP-Seq_THP-1_Human1.28901725
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28021349
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.26652669
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26399602
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25147645
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.25035905
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24892674
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24813349
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23818417
78TFEB_21752829_ChIP-Seq_HELA_Human1.23675410
79TCF7_22412390_ChIP-Seq_EML_Mouse1.23453797
80AR_21572438_ChIP-Seq_LNCaP_Human1.23404338
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23110203
82MYC_22102868_ChIP-Seq_BL_Human1.22439161
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22182281
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21861103
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21761550
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17015423
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16202320
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16039637
89* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15563955
90* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14749686
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14101663
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13526413
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11541427
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11520642
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11428399
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.11420578
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11077093
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10794169
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10786881
100TP53_16413492_ChIP-PET_HCT116_Human1.09332030
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07303958
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06415469
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05773579
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05657823
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04795167
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04677569
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04067979
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03176308
109MAF_26560356_Chip-Seq_TH2_Human1.03081880
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02201322
111EED_16625203_ChIP-ChIP_MESCs_Mouse1.01503037
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01464941
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01441837
114KDM2B_26808549_Chip-Seq_DND41_Human1.01316758
115BRD4_25478319_ChIP-Seq_HGPS_Human1.01311252
116LXR_22292898_ChIP-Seq_THP-1_Human1.00723676
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00651476
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00551680
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99171506
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98825064
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.98380553
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98003689
123CLOCK_20551151_ChIP-Seq_293T_Human0.97201706
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96940223
125EGR1_19032775_ChIP-ChIP_M12_Human0.96040260
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95669425
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.95433640
128VDR_22108803_ChIP-Seq_LS180_Human0.95185184
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.94830068
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.93709288
131SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93686253
132GATA3_27048872_Chip-Seq_THYMUS_Human0.93426163
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92899636
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92660328
135GATA3_26560356_Chip-Seq_TH2_Human0.91089327
136ATF3_27146783_Chip-Seq_COLON_Human0.90591771
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88758047
138IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87905200
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86620642
140AHR_22903824_ChIP-Seq_MCF-7_Human0.86602871
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86347888
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.85473577
143GATA4_25053715_ChIP-Seq_YYC3_Human0.85421867
144MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85052192
145KLF5_25053715_ChIP-Seq_YYC3_Human0.83635898
146* BCAT_22108803_ChIP-Seq_LS180_Human0.82793660
147* TCF4_22108803_ChIP-Seq_LS180_Human0.82539469
148* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82336817
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82165435
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.81650476
151PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80178313
152WT1_19549856_ChIP-ChIP_CCG9911_Human0.79284773
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.77435041
154HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77214211
155SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.77110109
156SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75910820
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74640676
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73895107
159CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73834626
160NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.73610197
161* PU_27001747_Chip-Seq_BMDM_Mouse0.72386673
162JARID2_20075857_ChIP-Seq_MESCs_Mouse0.72208875
163SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70607288
164EZH2_18974828_ChIP-Seq_MESCs_Mouse0.70154428
165RNF2_18974828_ChIP-Seq_MESCs_Mouse0.70154428
166GATA1_22025678_ChIP-Seq_K562_Human0.68634729
167SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68422933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.58609833
2MP0002254_reproductive_system_inflammat5.24594555
3MP0005275_abnormal_skin_tensile4.51815060
4MP0003941_abnormal_skin_development3.81828113
5MP0010234_abnormal_vibrissa_follicle3.29099037
6MP0005501_abnormal_skin_physiology3.16769156
7MP0005451_abnormal_body_composition3.07616802
8MP0002060_abnormal_skin_morphology3.07143673
9MP0004947_skin_inflammation2.81243560
10MP0003705_abnormal_hypodermis_morpholog2.59514300
11MP0001216_abnormal_epidermal_layer2.58766121
12MP0003191_abnormal_cellular_cholesterol2.46147727
13MP0000383_abnormal_hair_follicle2.43400083
14MP0003453_abnormal_keratinocyte_physiol2.39283762
15MP0010771_integument_phenotype2.28785710
16MP0010678_abnormal_skin_adnexa2.25249023
17MP0000579_abnormal_nail_morphology2.23742212
18MP0004381_abnormal_hair_follicle2.19037236
19MP0003172_abnormal_lysosome_physiology2.14792892
20MP0001835_abnormal_antigen_presentation2.10951485
21MP0001346_abnormal_lacrimal_gland2.05536366
22MP0003436_decreased_susceptibility_to2.00436403
23MP0002098_abnormal_vibrissa_morphology1.89234126
24MP0002148_abnormal_hypersensitivity_rea1.87763982
25MP0006054_spinal_hemorrhage1.84065455
26MP0000858_altered_metastatic_potential1.81912868
27MP0000647_abnormal_sebaceous_gland1.80546879
28MP0000427_abnormal_hair_cycle1.76286725
29MP0003566_abnormal_cell_adhesion1.73132679
30MP0004782_abnormal_surfactant_physiolog1.68649688
31MP0000377_abnormal_hair_follicle1.56184474
32MP0001191_abnormal_skin_condition1.49801420
33MP0002419_abnormal_innate_immunity1.48174661
34MP0003091_abnormal_cell_migration1.48063192
35MP0008260_abnormal_autophagy1.46987915
36MP0001851_eye_inflammation1.46881912
37MP0008438_abnormal_cutaneous_collagen1.46556440
38MP0005164_abnormal_response_to1.46539170
39MP0003724_increased_susceptibility_to1.46496584
40MP0008004_abnormal_stomach_pH1.39736480
41MP0009931_abnormal_skin_appearance1.37049263
42MP0002877_abnormal_melanocyte_morpholog1.34961236
43MP0009333_abnormal_splenocyte_physiolog1.33491810
44MP0009278_abnormal_bone_marrow1.33117113
45MP0005397_hematopoietic_system_phenotyp1.31535854
46MP0001545_abnormal_hematopoietic_system1.31535854
47MP0009840_abnormal_foam_cell1.29076767
48MP0001533_abnormal_skeleton_physiology1.27961340
49MP0004185_abnormal_adipocyte_glucose1.26402676
50MP0005000_abnormal_immune_tolerance1.26373375
51MP0005025_abnormal_response_to1.26336987
52MP0000716_abnormal_immune_system1.26258710
53MP0000685_abnormal_immune_system1.25072785
54MP0003763_abnormal_thymus_physiology1.23288972
55MP0003950_abnormal_plasma_membrane1.23021678
56MP0009764_decreased_sensitivity_to1.21618688
57MP0010352_gastrointestinal_tract_polyps1.21454880
58MP0001243_abnormal_dermal_layer1.21177342
59MP0000566_synostosis1.20904029
60MP0005058_abnormal_lysosome_morphology1.19466121
61MP0009785_altered_susceptibility_to1.18889545
62MP0003656_abnormal_erythrocyte_physiolo1.14402097
63MP0002398_abnormal_bone_marrow1.12623596
64MP0000467_abnormal_esophagus_morphology1.11776842
65MP0002277_abnormal_respiratory_mucosa1.11075077
66MP0004883_abnormal_blood_vessel1.11003294
67MP0006082_CNS_inflammation1.08842956
68MP0003806_abnormal_nucleotide_metabolis1.07354287
69MP0005387_immune_system_phenotype1.07136999
70MP0001790_abnormal_immune_system1.07136999
71MP0002332_abnormal_exercise_endurance1.06999157
72MP0005257_abnormal_intraocular_pressure1.06452697
73MP0000367_abnormal_coat/_hair1.03321042
74MP0000465_gastrointestinal_hemorrhage1.01314087
75MP0001958_emphysema1.01127898
76MP0003828_pulmonary_edema1.00976076
77MP0004019_abnormal_vitamin_homeostasis1.00706338
78MP0000762_abnormal_tongue_morphology1.00275752
79MP0005165_increased_susceptibility_to0.99891256
80MP0002452_abnormal_antigen_presenting0.99802135
81MP0001853_heart_inflammation0.99718177
82MP0002429_abnormal_blood_cell0.98979825
83MP0003075_altered_response_to0.98439422
84MP0009763_increased_sensitivity_to0.96369710
85MP0002998_abnormal_bone_remodeling0.96299284
86MP0002009_preneoplasia0.94729985
87MP0005464_abnormal_platelet_physiology0.92548401
88MP0005023_abnormal_wound_healing0.92003640
89MP0000689_abnormal_spleen_morphology0.91032416
90MP0002722_abnormal_immune_system0.90988197
91MP0009384_cardiac_valve_regurgitation0.90864980
92MP0002139_abnormal_hepatobiliary_system0.88580356
93MP0005390_skeleton_phenotype0.87790919
94MP0001800_abnormal_humoral_immune0.86880667
95MP0004510_myositis0.86637322
96MP0002138_abnormal_hepatobiliary_system0.85281590
97MP0000249_abnormal_blood_vessel0.85191910
98MP0000604_amyloidosis0.85031220
99MP0004808_abnormal_hematopoietic_stem0.84195446
100MP0002723_abnormal_immune_serum0.83141539
101MP0001873_stomach_inflammation0.81732770
102MP0001845_abnormal_inflammatory_respons0.81179994
103MP0000343_altered_response_to0.79794820
104MP0001542_abnormal_bone_strength0.78696535
105MP0003448_altered_tumor_morphology0.78532570
106MP0010155_abnormal_intestine_physiology0.77733021
107MP0000767_abnormal_smooth_muscle0.75166963
108MP0003303_peritoneal_inflammation0.75128477
109MP0005647_abnormal_sex_gland0.74528163
110MP0002405_respiratory_system_inflammati0.73864138
111MP0000538_abnormal_urinary_bladder0.73697460
112MP0002933_joint_inflammation0.72326358
113MP0005167_abnormal_blood-brain_barrier0.71144550
114MP0002006_tumorigenesis0.70466640
115MP0003690_abnormal_glial_cell0.69555566
116MP0002166_altered_tumor_susceptibility0.68635071
117MP0000569_abnormal_digit_pigmentation0.68625130
118MP0002420_abnormal_adaptive_immunity0.68280226
119MP0001819_abnormal_immune_cell0.68243294
120MP0003300_gastrointestinal_ulcer0.67898962
121MP0003195_calcinosis0.67852222
122MP0009765_abnormal_xenobiotic_induced0.67506342
123MP0001340_abnormal_eyelid_morphology0.66035916
124MP0002876_abnormal_thyroid_physiology0.65753236
125MP0003279_aneurysm0.65737733
126MP0005310_abnormal_salivary_gland0.65047426
127MP0008469_abnormal_protein_level0.62067629
128MP0003045_fibrosis0.61434646
129MP0009379_abnormal_foot_pigmentation0.60356655
130MP0004272_abnormal_basement_membrane0.59650685
131MP0005166_decreased_susceptibility_to0.58752154
132MP0003795_abnormal_bone_structure0.57409261
133MP0005671_abnormal_response_to0.57004695
134MP0003183_abnormal_peptide_metabolism0.55294373
135MP0000627_abnormal_mammary_gland0.55236907

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.52522813
2Abnormality of liposaccharide metabolism (HP:0010968)5.03560138
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.03560138
4Abnormality of glycolipid metabolism (HP:0010969)5.03560138
5Increased IgE level (HP:0003212)4.81285806
6Systemic lupus erythematosus (HP:0002725)4.69733928
7Congenital ichthyosiform erythroderma (HP:0007431)4.60753514
8Plantar hyperkeratosis (HP:0007556)4.45295354
9Onycholysis (HP:0001806)4.30063929
10Thick nail (HP:0001805)4.20209812
11Hypotrichosis (HP:0001006)4.01766596
12Fragile nails (HP:0001808)3.99198311
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.99127998
14Right ventricular cardiomyopathy (HP:0011663)3.89615252
15Palmoplantar hyperkeratosis (HP:0000972)3.79611341
16Abnormality of nail color (HP:0100643)3.78974235
17Recurrent abscess formation (HP:0002722)3.69853633
18Gangrene (HP:0100758)3.68000677
19Lip pit (HP:0100267)3.66925420
20Recurrent bacterial skin infections (HP:0005406)3.61146617
21Palmar hyperkeratosis (HP:0010765)3.55561376
22Parakeratosis (HP:0001036)3.51266715
23Prostate neoplasm (HP:0100787)3.49571934
24Milia (HP:0001056)3.45921878
25Elevated erythrocyte sedimentation rate (HP:0003565)3.37200598
26Erythema (HP:0010783)3.34756891
27Erythroderma (HP:0001019)3.31567937
28Loss of speech (HP:0002371)3.29679934
29Recurrent gram-negative bacterial infections (HP:0005420)3.27725005
30Ectropion (HP:0000656)3.27279182
31Woolly hair (HP:0002224)3.20764168
32Distal lower limb muscle weakness (HP:0009053)3.15665667
33Optic neuritis (HP:0100653)3.11898691
34Retrobulbar optic neuritis (HP:0100654)3.11898691
35Alopecia of scalp (HP:0002293)3.08359510
36Corneal erosion (HP:0200020)3.04773760
37Glomerulonephritis (HP:0000099)2.95676681
38Atrophic scars (HP:0001075)2.94899276
39Stomatitis (HP:0010280)2.88081536
40Abnormality of polysaccharide metabolism (HP:0011012)2.86757101
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86757101
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86757101
43Spondylolisthesis (HP:0003302)2.85643556
44Abnormality of complement system (HP:0005339)2.84481316
45Mucopolysacchariduria (HP:0008155)2.78194123
46Urinary glycosaminoglycan excretion (HP:0003541)2.78194123
47Pruritus (HP:0000989)2.74311385
48Aplasia cutis congenita (HP:0001057)2.73568246
49Increased cerebral lipofuscin (HP:0011813)2.71417461
50Xerostomia (HP:0000217)2.66345611
51Nail dystrophy (HP:0008404)2.62594468
52Autoimmune thrombocytopenia (HP:0001973)2.61259890
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.60919751
54Vasculitis (HP:0002633)2.53448073
55Congenital malformation of the right heart (HP:0011723)2.53280752
56Double outlet right ventricle (HP:0001719)2.53280752
57Natal tooth (HP:0000695)2.52901219
58Vacuolated lymphocytes (HP:0001922)2.51394747
59Abnormality of macrophages (HP:0004311)2.50964528
60Complement deficiency (HP:0004431)2.48067834
61Abnormal blistering of the skin (HP:0008066)2.47577324
62Nephritis (HP:0000123)2.43001492
63Vertebral compression fractures (HP:0002953)2.42493223
64Hemoptysis (HP:0002105)2.42248329
65Hypohidrosis (HP:0000966)2.42135900
66Pustule (HP:0200039)2.41877859
67Urticaria (HP:0001025)2.40532962
68Recurrent skin infections (HP:0001581)2.39915033
69Abnormality of the axillary hair (HP:0100134)2.35240179
70Abnormality of secondary sexual hair (HP:0009888)2.35240179
71Recurrent viral infections (HP:0004429)2.34176824
72Keratoconjunctivitis sicca (HP:0001097)2.33670497
73Osteolytic defects of the hand bones (HP:0009699)2.30497489
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.30497489
75Disinhibition (HP:0000734)2.27607026
76Abnormality of proline metabolism (HP:0010907)2.27161511
77Hydroxyprolinuria (HP:0003080)2.27161511
78Meningitis (HP:0001287)2.26781101
79Axonal loss (HP:0003447)2.26665052
80Advanced eruption of teeth (HP:0006288)2.26476684
81Neurofibrillary tangles (HP:0002185)2.26277778
82Spontaneous hematomas (HP:0007420)2.23154195
83Myocardial infarction (HP:0001658)2.21640140
84Amyloidosis (HP:0011034)2.21508912
85Thrombocytosis (HP:0001894)2.21073692
86Mediastinal lymphadenopathy (HP:0100721)2.20518633
87Acanthosis nigricans (HP:0000956)2.19406821
88Hematochezia (HP:0002573)2.18357615
89Orchitis (HP:0100796)2.16776408
90Conical tooth (HP:0000698)2.16362216
91Hypergammaglobulinemia (HP:0010702)2.15143922
92Gingivitis (HP:0000230)2.15102326
93Hyporeflexia of lower limbs (HP:0002600)2.13303833
94Joint hemorrhage (HP:0005261)2.13284406
95Peritonitis (HP:0002586)2.12850925
96Premature loss of primary teeth (HP:0006323)2.11212427
97Hepatosplenomegaly (HP:0001433)2.10853449
98Keratoconjunctivitis (HP:0001096)2.10609245
99Increased serum ferritin (HP:0003281)2.09391086
100Petechiae (HP:0000967)2.09185463
101Gastrointestinal infarctions (HP:0005244)2.05792757
102Cellulitis (HP:0100658)2.05609299
103Chest pain (HP:0100749)2.03579797
104Gingival bleeding (HP:0000225)2.02650054
105Xanthomatosis (HP:0000991)2.02111622
106Sepsis (HP:0100806)2.00756159
107Anhidrosis (HP:0000970)1.99848346
108Epistaxis (HP:0000421)1.99639212
109Nuclear cataract (HP:0100018)1.97974016
110Abnormality of the pericardium (HP:0001697)1.97862141
111Arterial thrombosis (HP:0004420)1.96937354
112T lymphocytopenia (HP:0005403)1.95877888
113Leukocytosis (HP:0001974)1.94664007
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94088912
115Glomerulopathy (HP:0100820)1.93475256
116Periodontitis (HP:0000704)1.92590316
117Mutism (HP:0002300)1.92364115
118Polyneuropathy (HP:0001271)1.92030734
119Purpura (HP:0000979)1.91995995
120Progressive neurologic deterioration (HP:0002344)1.89806877
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89390407
122Skin ulcer (HP:0200042)1.89291854
123Upper limb muscle weakness (HP:0003484)1.88743278
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.88130124
125Tetraparesis (HP:0002273)1.87471978
126Asymmetric septal hypertrophy (HP:0001670)1.87094023
127Myositis (HP:0100614)1.86914424
128Abnormality of T cell number (HP:0011839)1.86599854
129Interstitial pulmonary disease (HP:0006530)1.86517602
130Fragile skin (HP:0001030)1.86216414
131Chronic obstructive pulmonary disease (HP:0006510)1.85929638
132Obstructive lung disease (HP:0006536)1.85929638
133Recurrent cutaneous fungal infections (HP:0011370)1.85001575
134Chronic mucocutaneous candidiasis (HP:0002728)1.85001575
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.84938774
136Basal ganglia calcification (HP:0002135)1.83412394
137Palmoplantar keratoderma (HP:0000982)1.83351490
138Apathy (HP:0000741)1.82740623
139Autoimmune hemolytic anemia (HP:0001890)1.82709706
140Bone pain (HP:0002653)1.82408118
141Fatigue (HP:0012378)1.82168260
142Diminished motivation (HP:0000745)1.81653124
143Recurrent corneal erosions (HP:0000495)1.81551294
144Recurrent fungal infections (HP:0002841)1.80561503
145Corneal dystrophy (HP:0001131)1.79149019
146Premature rupture of membranes (HP:0001788)1.79097155
147Sparse scalp hair (HP:0002209)1.76462271
148Abnormality of the nasal septum (HP:0000419)1.74980823
149Pulmonary infiltrates (HP:0002113)1.74228550
150Curly hair (HP:0002212)1.73403550
151Dysostosis multiplex (HP:0000943)1.72662987
152Malignant hyperthermia (HP:0002047)1.71653464
153Lack of skin elasticity (HP:0100679)1.71500989
154Ventricular tachycardia (HP:0004756)1.71487084
155Hypoplasia of dental enamel (HP:0006297)1.71470880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.47408167
2MAP3K143.44826362
3BLK2.91704917
4PRPF4B2.43021049
5TGFBR22.36845225
6TYK22.36097306
7MAPKAPK32.34132061
8TRPM72.29997538
9ERN12.14665655
10RIPK42.14514075
11EPHA32.10001837
12MAP2K32.08554450
13NME22.01206535
14CSK1.97084088
15MET1.96564729
16MAP4K11.85163023
17EPHB21.83173608
18MAP3K31.83115484
19IRAK41.82874062
20ZAP701.82669470
21BMPR21.82122766
22IKBKE1.77634345
23PIK3CG1.75562847
24ERBB31.71322203
25FER1.70196697
26TBK11.70145274
27MST41.69068477
28MAP3K131.64670694
29PIM21.64417224
30IRAK31.64123338
31GRK71.59201915
32IKBKB1.57692282
33SIK31.53133673
34LATS11.50950705
35TAOK11.40457114
36TEC1.39324273
37SIK11.36033894
38STK101.34424996
39BMPR1B1.26862772
40LRRK21.25448610
41ARAF1.23957257
42PTK61.23793785
43FES1.23660926
44BMX1.22825849
45CASK1.15997253
46MOS1.15732141
47EIF2AK21.14269253
48PAK41.08726025
49RPS6KA41.07046246
50TESK21.05954286
51TESK11.05503011
52HCK1.02590729
53EPHB11.02214681
54JAK11.02075097
55CDC42BPA1.01684866
56FGFR40.98414875
57GRK50.95482593
58MAP3K20.94018718
59MAPKAPK50.93831475
60RIPK10.93238586
61NLK0.90667681
62KIT0.90213164
63CHUK0.89989410
64INSRR0.88464453
65PBK0.87976485
66MYLK0.85330219
67MAP3K50.85170374
68PDGFRA0.84452328
69JAK30.84105316
70ITK0.83065435
71MAP3K110.82179358
72JAK20.80377539
73TTN0.80254169
74FRK0.77576032
75BTK0.76800883
76IRAK10.76125367
77MAP3K10.75950787
78MAP3K120.74851972
79FGFR10.74825085
80IRAK20.73094063
81SYK0.70939053
82FGFR30.68454615
83PDGFRB0.65539266
84PRKD20.64500714
85MAP2K10.64431765
86MAPKAPK20.63583733
87MAP2K20.59336371
88FGR0.59228555
89STK240.58367723
90TAOK30.58294932
91CDK80.56888813
92MAPK120.56801968
93MAP3K60.54714551
94CDK60.54537104
95FLT30.54509208
96NEK90.53918449
97ERBB40.53681681
98CDK190.53590797
99MAPK70.52018976
100KSR20.51988176
101PRKCD0.51581188
102CSF1R0.50045662
103PRKCE0.50032932
104LIMK10.49426284
105GRK60.49396819
106PDPK10.49013934
107LYN0.47380409
108TGFBR10.46243072
109DAPK20.45922584
110MAP3K80.45833077
111IGF1R0.44887730
112DYRK1B0.44246639
113STK30.43931585
114MATK0.43774753
115EGFR0.43351167
116PDK10.43132261
117CDK30.43009062
118MARK30.42694051
119EIF2AK30.42632471
120GRK10.42506526
121ABL20.41522395
122ABL10.39825303
123PAK20.39725536
124SIK20.39643049
125TAOK20.39283310
126PTK20.39031326
127LCK0.37893000
128MAPK40.36115265
129NTRK10.35715949
130TXK0.35142063
131TRIB30.34841194
132PTK2B0.34709112
133ADRBK20.34050030
134DDR20.33191598
135CAMK1D0.33046043
136CLK10.32898352
137GSK3A0.32419513
138EPHA20.31611791
139HIPK20.30551864
140INSR0.30338202
141RPS6KC10.29146489
142RPS6KL10.29146489

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.92826380
2Complement and coagulation cascades_Homo sapiens_hsa046102.32421163
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.26501588
4Pertussis_Homo sapiens_hsa051332.17040246
5Leishmaniasis_Homo sapiens_hsa051402.11993406
6Autoimmune thyroid disease_Homo sapiens_hsa053202.04572649
7Malaria_Homo sapiens_hsa051441.98731100
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92287179
9Rheumatoid arthritis_Homo sapiens_hsa053231.85220172
10Type I diabetes mellitus_Homo sapiens_hsa049401.77170985
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.76381416
12Sphingolipid metabolism_Homo sapiens_hsa006001.71885059
13Osteoclast differentiation_Homo sapiens_hsa043801.71573959
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69588755
15Lysosome_Homo sapiens_hsa041421.65587649
16Viral myocarditis_Homo sapiens_hsa054161.60867937
17Tuberculosis_Homo sapiens_hsa051521.60422057
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55597451
19Histidine metabolism_Homo sapiens_hsa003401.55305564
20Arachidonic acid metabolism_Homo sapiens_hsa005901.51959619
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51673958
22Phagosome_Homo sapiens_hsa041451.51511843
23Amoebiasis_Homo sapiens_hsa051461.49175771
24Legionellosis_Homo sapiens_hsa051341.45703005
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45696046
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.45147113
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43788102
28Other glycan degradation_Homo sapiens_hsa005111.35785662
29Arginine biosynthesis_Homo sapiens_hsa002201.30599187
30ABC transporters_Homo sapiens_hsa020101.28256162
31Caffeine metabolism_Homo sapiens_hsa002321.20053036
32Herpes simplex infection_Homo sapiens_hsa051681.19956804
33Asthma_Homo sapiens_hsa053101.17400774
34Toxoplasmosis_Homo sapiens_hsa051451.17353891
35Chemical carcinogenesis_Homo sapiens_hsa052041.16782419
36Retinol metabolism_Homo sapiens_hsa008301.16531881
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15458352
38Hepatitis B_Homo sapiens_hsa051611.14480547
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13638403
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12265809
41TNF signaling pathway_Homo sapiens_hsa046681.12183051
42Linoleic acid metabolism_Homo sapiens_hsa005911.09936511
43Acute myeloid leukemia_Homo sapiens_hsa052211.08265195
44Bladder cancer_Homo sapiens_hsa052191.07295050
45Salmonella infection_Homo sapiens_hsa051321.05821131
46African trypanosomiasis_Homo sapiens_hsa051431.03851055
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02596259
48Hematopoietic cell lineage_Homo sapiens_hsa046401.00759565
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.00468989
50T cell receptor signaling pathway_Homo sapiens_hsa046600.99307406
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.99116467
52Phenylalanine metabolism_Homo sapiens_hsa003600.96691249
53ECM-receptor interaction_Homo sapiens_hsa045120.95470795
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95354444
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94238235
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92852307
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.92695078
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89375728
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.88327116
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.86917782
61Prion diseases_Homo sapiens_hsa050200.86884766
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86748463
63Proteoglycans in cancer_Homo sapiens_hsa052050.85472455
64Primary immunodeficiency_Homo sapiens_hsa053400.85462099
65Chemokine signaling pathway_Homo sapiens_hsa040620.82604984
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81716900
67Hepatitis C_Homo sapiens_hsa051600.79506454
68Collecting duct acid secretion_Homo sapiens_hsa049660.79353418
69Melanoma_Homo sapiens_hsa052180.79141763
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78203660
71Chronic myeloid leukemia_Homo sapiens_hsa052200.76587027
72Apoptosis_Homo sapiens_hsa042100.74641204
73VEGF signaling pathway_Homo sapiens_hsa043700.74164464
74Measles_Homo sapiens_hsa051620.73420128
75PPAR signaling pathway_Homo sapiens_hsa033200.73408803
76Fatty acid elongation_Homo sapiens_hsa000620.73269314
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73247556
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72125056
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71127748
80Graft-versus-host disease_Homo sapiens_hsa053320.71110100
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.69158061
82Influenza A_Homo sapiens_hsa051640.67370043
83Epstein-Barr virus infection_Homo sapiens_hsa051690.66976168
84Platelet activation_Homo sapiens_hsa046110.66370142
85Basal cell carcinoma_Homo sapiens_hsa052170.65738315
86Adherens junction_Homo sapiens_hsa045200.64372161
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64246421
88Ether lipid metabolism_Homo sapiens_hsa005650.62337982
89Mineral absorption_Homo sapiens_hsa049780.61793747
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58441143
91Vitamin digestion and absorption_Homo sapiens_hsa049770.57539343
92Prolactin signaling pathway_Homo sapiens_hsa049170.57429782
93B cell receptor signaling pathway_Homo sapiens_hsa046620.57295346
94Renal cell carcinoma_Homo sapiens_hsa052110.56930773
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55595002
96HTLV-I infection_Homo sapiens_hsa051660.54372644
97Vibrio cholerae infection_Homo sapiens_hsa051100.54334845
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54051959
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.52976409
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50010002
101Peroxisome_Homo sapiens_hsa041460.48305379
102beta-Alanine metabolism_Homo sapiens_hsa004100.47788357
103HIF-1 signaling pathway_Homo sapiens_hsa040660.47324077
104Pancreatic cancer_Homo sapiens_hsa052120.46945571
105Fatty acid degradation_Homo sapiens_hsa000710.46879881
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.46778108
107Focal adhesion_Homo sapiens_hsa045100.46421378
108Non-small cell lung cancer_Homo sapiens_hsa052230.45968326
109TGF-beta signaling pathway_Homo sapiens_hsa043500.45862186
110Allograft rejection_Homo sapiens_hsa053300.45511627
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44423624
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.44046905
113Rap1 signaling pathway_Homo sapiens_hsa040150.43484566
114Ras signaling pathway_Homo sapiens_hsa040140.43198261
115Small cell lung cancer_Homo sapiens_hsa052220.42577500
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42328493
117Dorso-ventral axis formation_Homo sapiens_hsa043200.41732048
118Tyrosine metabolism_Homo sapiens_hsa003500.40956364
119Nitrogen metabolism_Homo sapiens_hsa009100.40558859
120Viral carcinogenesis_Homo sapiens_hsa052030.40366475
121Antigen processing and presentation_Homo sapiens_hsa046120.40345135
122Fatty acid biosynthesis_Homo sapiens_hsa000610.39770648
123Shigellosis_Homo sapiens_hsa051310.39168993
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38159920
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37978260
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37533035
127GnRH signaling pathway_Homo sapiens_hsa049120.35511131
128Galactose metabolism_Homo sapiens_hsa000520.35364789
129Endocytosis_Homo sapiens_hsa041440.34604522
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34301570
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.33107653
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31680520
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29785897
134Notch signaling pathway_Homo sapiens_hsa043300.29374335
135Sulfur metabolism_Homo sapiens_hsa009200.28631523
136Prostate cancer_Homo sapiens_hsa052150.24879676
137MAPK signaling pathway_Homo sapiens_hsa040100.24262039
138FoxO signaling pathway_Homo sapiens_hsa040680.24219209
139Insulin resistance_Homo sapiens_hsa049310.21856657

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