SERPINB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serine transport (GO:0032329)6.13660358
2L-serine transport (GO:0015825)6.10030751
3phospholipid scrambling (GO:0017121)5.95627737
4antigen processing and presentation of endogenous antigen (GO:0019883)5.63387103
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.59583316
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.59583316
7DNA deamination (GO:0045006)5.40882795
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.30079715
9positive regulation of natural killer cell differentiation (GO:0032825)5.18397746
10endoderm formation (GO:0001706)5.12292973
11positive regulation of T-helper cell differentiation (GO:0045624)5.10444617
12regulation of T-helper 1 cell differentiation (GO:0045625)5.07402566
13negative regulation of viral genome replication (GO:0045071)5.06896394
14myeloid dendritic cell differentiation (GO:0043011)5.06471147
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.00720817
16NIK/NF-kappaB signaling (GO:0038061)4.91634105
17regulation of mesoderm development (GO:2000380)4.85660836
18regulation of T-helper 2 cell differentiation (GO:0045628)4.81726216
19positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.68994735
20cytidine metabolic process (GO:0046087)4.66908116
21cytidine catabolic process (GO:0006216)4.66908116
22cytidine deamination (GO:0009972)4.66908116
23Rap protein signal transduction (GO:0032486)4.61407323
24positive regulation of type 2 immune response (GO:0002830)4.60969581
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.56736056
26myeloid dendritic cell activation (GO:0001773)4.56619862
27regulation of T cell tolerance induction (GO:0002664)4.48385165
28somite rostral/caudal axis specification (GO:0032525)4.45220188
29regulation of activation of Janus kinase activity (GO:0010533)4.43432986
30regulation of memory T cell differentiation (GO:0043380)4.35969223
31positive regulation of alpha-beta T cell proliferation (GO:0046641)4.30756055
32positive regulation of interleukin-12 production (GO:0032735)4.30248549
33neutrophil activation involved in immune response (GO:0002283)4.29703252
34T-helper 1 type immune response (GO:0042088)4.27860327
35interferon-gamma production (GO:0032609)4.18990130
36positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.14303924
37cellular response to type I interferon (GO:0071357)4.14255359
38type I interferon signaling pathway (GO:0060337)4.14255359
39regulation of T-helper cell differentiation (GO:0045622)4.13166383
40regulation of alpha-beta T cell proliferation (GO:0046640)4.11972334
41response to type I interferon (GO:0034340)4.11864028
42negative thymic T cell selection (GO:0045060)4.11561258
43pyrimidine ribonucleoside catabolic process (GO:0046133)4.11113909
44regulation of interleukin-12 biosynthetic process (GO:0045075)4.09881278
45regulation of RIG-I signaling pathway (GO:0039535)4.09357174
46natural killer cell activation (GO:0030101)4.00578512
47positive regulation of activated T cell proliferation (GO:0042104)4.00261445
48negative regulation of activin receptor signaling pathway (GO:0032926)3.95064656
49primitive streak formation (GO:0090009)3.92933096
50negative T cell selection (GO:0043383)3.91977514
51natural killer cell differentiation (GO:0001779)3.86491595
52positive regulation of gamma-delta T cell activation (GO:0046645)3.82603398
53neutrophil activation (GO:0042119)3.81355257
54regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.81256335
55positive regulation of isotype switching (GO:0045830)3.80216693
56positive regulation of interleukin-2 production (GO:0032743)3.78400334
57growth hormone receptor signaling pathway (GO:0060396)3.77506408
58regulation of natural killer cell mediated immunity (GO:0002715)3.74861973
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.74861973
60regulation of immunoglobulin secretion (GO:0051023)3.74622583
61dendritic cell differentiation (GO:0097028)3.73915377
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.71133511
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.71058022
64granulocyte activation (GO:0036230)3.70850138
65response to muramyl dipeptide (GO:0032495)3.67721055
66interferon-gamma-mediated signaling pathway (GO:0060333)3.64126320
67positive regulation of heat generation (GO:0031652)3.64073080
68regulation of natural killer cell differentiation (GO:0032823)3.60493470
69positive regulation of defense response to virus by host (GO:0002230)3.59743269
70regulation of viral genome replication (GO:0045069)3.56715059
71negative regulation of B cell proliferation (GO:0030889)3.55292252
72positive regulation of interferon-alpha production (GO:0032727)3.54877693
73positive regulation of natural killer cell mediated immunity (GO:0002717)3.53862504
74positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.53862504
75positive regulation of T cell cytokine production (GO:0002726)3.53597916
76natural killer cell mediated immunity (GO:0002228)3.52627603
77natural killer cell mediated cytotoxicity (GO:0042267)3.52627603
78regulation of T-helper 1 type immune response (GO:0002825)3.50501461
79response to interferon-alpha (GO:0035455)3.50224835
80cellular response to zinc ion (GO:0071294)3.49480725
81cell migration involved in gastrulation (GO:0042074)3.48579957
82regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.48100554
83positive regulation of T-helper 1 type immune response (GO:0002827)3.46778288
84regulation of fever generation (GO:0031620)3.45114511
85regulation of tolerance induction (GO:0002643)3.43855300
86negative regulation of interleukin-17 production (GO:0032700)3.42344879
87positive regulation of DNA recombination (GO:0045911)3.40960738
88defense response to protozoan (GO:0042832)3.40755301
89positive regulation of antigen processing and presentation (GO:0002579)3.39806051
90regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.38417375
91positive regulation of NF-kappaB import into nucleus (GO:0042346)3.37315909
92T cell activation involved in immune response (GO:0002286)3.36459009
93regulation of hypersensitivity (GO:0002883)3.36099106
94immunoglobulin mediated immune response (GO:0016064)3.35097983
95regulation of interferon-alpha production (GO:0032647)3.34848072
96CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.33726083
97T-helper cell differentiation (GO:0042093)3.33726083
98positive regulation of B cell differentiation (GO:0045579)3.33352128
99mucosal-associated lymphoid tissue development (GO:0048537)3.32800119
100Peyers patch development (GO:0048541)3.32800119
101regulation of chronic inflammatory response (GO:0002676)3.30615928
102T cell differentiation involved in immune response (GO:0002292)3.29900563
103alpha-beta T cell differentiation involved in immune response (GO:0002293)3.29900563
104alpha-beta T cell activation involved in immune response (GO:0002287)3.29900563
105anterior/posterior axis specification (GO:0009948)3.27431125
106regulation of interleukin-12 production (GO:0032655)3.26511789
107positive regulation of humoral immune response (GO:0002922)3.26446480
108cellular response to growth hormone stimulus (GO:0071378)3.24787281
109regulation of interleukin-2 biosynthetic process (GO:0045076)3.22937708
110regulation of leukocyte mediated cytotoxicity (GO:0001910)3.22904732
111regulation of B cell receptor signaling pathway (GO:0050855)3.22177843
112positive regulation of macrophage differentiation (GO:0045651)3.21424812
113regulation of activin receptor signaling pathway (GO:0032925)3.20412259
114cellular response to interleukin-15 (GO:0071350)3.19459716
115positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16815725
116response to interleukin-15 (GO:0070672)3.16141279
117regulation of lymphocyte chemotaxis (GO:1901623)3.15252278
118regulation of isotype switching to IgG isotypes (GO:0048302)3.13422707
119antigen processing and presentation via MHC class Ib (GO:0002475)3.12869679
120nodal signaling pathway (GO:0038092)3.12481964
121positive regulation of T cell proliferation (GO:0042102)3.12049984
122positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.11863355
123positive regulation of alpha-beta T cell differentiation (GO:0046638)3.11695107
124regulation of interleukin-17 production (GO:0032660)3.10794223
125negative regulation of interleukin-12 production (GO:0032695)3.10610087
126response to protozoan (GO:0001562)3.09920865
127positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08431008
128anterior/posterior axis specification, embryo (GO:0008595)3.07625552
129negative regulation of viral process (GO:0048525)3.07519507
130B cell mediated immunity (GO:0019724)3.06737139
131positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.06654581
132response to interferon-beta (GO:0035456)3.06620205
133T cell migration (GO:0072678)3.06189788
134positive regulation of B cell mediated immunity (GO:0002714)3.05301199
135positive regulation of immunoglobulin mediated immune response (GO:0002891)3.05301199
136regulation of regulatory T cell differentiation (GO:0045589)3.04937973
137positive regulation of interleukin-17 production (GO:0032740)3.04890106
138monocyte chemotaxis (GO:0002548)3.03275175
139regulation of cytokine secretion involved in immune response (GO:0002739)3.01514434
140regulation of vitamin D biosynthetic process (GO:0060556)2.89706452
141positive regulation of interferon-beta production (GO:0032728)2.89219170
142positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82446241
143regulation of B cell differentiation (GO:0045577)2.82029601
144positive regulation of prostaglandin secretion (GO:0032308)2.79619709
145platelet dense granule organization (GO:0060155)2.79280342
146defense response to virus (GO:0051607)2.78537891
147embryonic axis specification (GO:0000578)2.76124411
148cellular response to interferon-gamma (GO:0071346)2.75863140
149regulation of interleukin-1 beta secretion (GO:0050706)2.74627276
150sequestering of extracellular ligand from receptor (GO:0035581)2.72041443
151regulation of NF-kappaB import into nucleus (GO:0042345)2.70621465
152positive regulation of lymphocyte migration (GO:2000403)2.70182619
153RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70025863
154negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69760601
155positive regulation of interleukin-1 beta secretion (GO:0050718)2.69755892
156mast cell activation (GO:0045576)2.69098064
157response to interferon-gamma (GO:0034341)2.68791103
158cellular response to interleukin-6 (GO:0071354)2.65875749
159positive regulation of mRNA catabolic process (GO:0061014)2.65256269
160somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65146402
161isotype switching (GO:0045190)2.65146402
162somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65146402
163vitamin catabolic process (GO:0009111)2.62681618
164fat-soluble vitamin catabolic process (GO:0042363)2.62681618
165branching involved in labyrinthine layer morphogenesis (GO:0060670)2.62391181
166regulation of heat generation (GO:0031650)2.61234155
167regulation of interferon-beta biosynthetic process (GO:0045357)2.60379281
168female gonad development (GO:0008585)2.58242421
169signal transduction involved in regulation of gene expression (GO:0023019)2.58193415
170regulation of T cell chemotaxis (GO:0010819)2.56492560
171positive regulation of T cell chemotaxis (GO:0010820)2.56492560
172negative regulation of B cell activation (GO:0050869)2.55029242
173regulation of prostaglandin secretion (GO:0032306)2.52361683
174regulation of interferon-beta production (GO:0032648)2.51930430
175negative regulation of T cell mediated immunity (GO:0002710)2.51889872
176regulation of defense response to virus by host (GO:0050691)2.51861557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.69691989
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.02042201
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.49897448
4IRF8_21731497_ChIP-ChIP_J774_Mouse5.38295602
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.98170785
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.52036602
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.67888180
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.63845340
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.55548605
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45566625
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.39024441
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.24477237
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.95896866
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.93788868
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88345635
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77823903
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.74543493
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72880015
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72880015
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72880015
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65872432
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62259965
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.61804112
24SMAD3_21741376_ChIP-Seq_HESCs_Human2.58736939
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52587440
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.49939153
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42681161
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.37103705
29MYB_26560356_Chip-Seq_TH2_Human2.31727202
30RUNX_20019798_ChIP-Seq_JUKART_Human2.28506830
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.12784514
32* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.12703489
33MAF_26560356_Chip-Seq_TH1_Human2.10838932
34PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03654346
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97369002
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96545257
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96251622
38SMAD4_21741376_ChIP-Seq_HESCs_Human1.96244093
39MYB_26560356_Chip-Seq_TH1_Human1.95297263
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92926762
41VDR_24787735_ChIP-Seq_THP-1_Human1.82005600
42EOMES_21245162_ChIP-Seq_HESCs_Human1.78303163
43VDR_22108803_ChIP-Seq_LS180_Human1.72870936
44GATA1_22025678_ChIP-Seq_K562_Human1.71219564
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67295755
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.64676138
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63040041
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.61772881
49SPI1_23547873_ChIP-Seq_NB4_Human1.60289486
50* GATA3_27048872_Chip-Seq_THYMUS_Human1.55346859
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.47094519
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.45567522
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43472828
54* P300_19829295_ChIP-Seq_ESCs_Human1.43228574
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42959885
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41772390
57ELK1_19687146_ChIP-ChIP_HELA_Human1.41469707
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38857579
59BCAT_22108803_ChIP-Seq_LS180_Human1.36261592
60VDR_24763502_ChIP-Seq_THP-1_Human1.36048004
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35894836
62GATA3_26560356_Chip-Seq_TH2_Human1.33247324
63PU_27001747_Chip-Seq_BMDM_Mouse1.32297570
64SCL_19346495_ChIP-Seq_HPC-7_Human1.29476851
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.26899289
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26888252
67* SMAD4_21741376_ChIP-Seq_EPCs_Human1.26762928
68SPI1_23127762_ChIP-Seq_K562_Human1.26198711
69VDR_23849224_ChIP-Seq_CD4+_Human1.25971857
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24192789
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22287567
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21669213
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21281723
74FOXP3_21729870_ChIP-Seq_TREG_Human1.21211458
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19161927
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18431168
77NANOG_19829295_ChIP-Seq_ESCs_Human1.17548525
78SOX2_19829295_ChIP-Seq_ESCs_Human1.17548525
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16396313
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.16210096
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15241259
82CLOCK_20551151_ChIP-Seq_293T_Human1.13975203
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.13925926
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13380282
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13380282
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13072295
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12630806
88MAF_26560356_Chip-Seq_TH2_Human1.12292738
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11148775
90VDR_21846776_ChIP-Seq_THP-1_Human1.10890788
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.10813467
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10253320
93UTX_26944678_Chip-Seq_JUKART_Human1.07750587
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07327160
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06757421
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05333863
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05005711
98TCF7_22412390_ChIP-Seq_EML_Mouse1.04918317
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.04299811
100* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03802740
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03674554
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.03055658
103ZNF274_21170338_ChIP-Seq_K562_Hela1.03005104
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00990608
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00764761
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00608441
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98776622
108CRX_20693478_ChIP-Seq_RETINA_Mouse0.97923963
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97877150
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96214896
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96001554
112* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95606045
113* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95375075
114GATA3_26560356_Chip-Seq_TH1_Human0.94910280
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93991956
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93163543
117EGR1_19032775_ChIP-ChIP_M12_Human0.92363370
118SOX2_20726797_ChIP-Seq_SW620_Human0.92326780
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92109563
120OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91839746
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.91580666
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90694272
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90663326
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90564573
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90401379
126* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88005779
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87776951
128EWS_26573619_Chip-Seq_HEK293_Human0.86566475
129TP53_22573176_ChIP-Seq_HFKS_Human0.86331058
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.85682857
131* CDX2_22108803_ChIP-Seq_LS180_Human0.85089135
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85071111
133CJUN_26792858_Chip-Seq_BT549_Human0.84907921
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82968676
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82877922
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82751270
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82483422
138GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82248803
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80252842
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80247072
141JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80108804
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78959578
143* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78857887
144* SMRT_27268052_Chip-Seq_Bcells_Human0.77102057
145* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76555377
146* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76555377
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75378518
148EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74663015
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73575222
150ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73349211
151RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73330237
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72870586
153KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72332208
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70957937
155KDM2B_26808549_Chip-Seq_DND41_Human0.70394892
156ELF1_17652178_ChIP-ChIP_JURKAT_Human0.69463701
157TRIM28_21343339_ChIP-Seq_HEK293_Human0.68187633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH6.29290543
2MP0001835_abnormal_antigen_presentation5.15717444
3MP0003890_abnormal_embryonic-extraembry4.33049793
4MP0000685_abnormal_immune_system4.13820604
5* MP0005671_abnormal_response_to3.97720361
6MP0009785_altered_susceptibility_to3.68932539
7MP0005387_immune_system_phenotype3.56519867
8MP0001790_abnormal_immune_system3.56519867
9MP0002138_abnormal_hepatobiliary_system3.38986592
10MP0002148_abnormal_hypersensitivity_rea3.20002061
11MP0002166_altered_tumor_susceptibility3.06981301
12MP0006082_CNS_inflammation2.98628668
13MP0001348_abnormal_lacrimal_gland2.92333514
14MP0005000_abnormal_immune_tolerance2.89758692
15MP0003724_increased_susceptibility_to2.78358235
16MP0002006_tumorigenesis2.68099791
17MP0003195_calcinosis2.68008660
18MP0001800_abnormal_humoral_immune2.66252912
19MP0003436_decreased_susceptibility_to2.64888944
20MP0004510_myositis2.61989455
21MP0002163_abnormal_gland_morphology2.60725816
22* MP0005025_abnormal_response_to2.55475741
23MP0002723_abnormal_immune_serum2.52400386
24MP0002452_abnormal_antigen_presenting2.37997690
25* MP0001819_abnormal_immune_cell2.29561942
26MP0002254_reproductive_system_inflammat2.26035957
27* MP0002420_abnormal_adaptive_immunity2.26018891
28MP0002419_abnormal_innate_immunity2.08160919
29MP0001346_abnormal_lacrimal_gland2.05711361
30MP0005394_taste/olfaction_phenotype1.94984999
31MP0005499_abnormal_olfactory_system1.94984999
32MP0003763_abnormal_thymus_physiology1.92514664
33MP0002736_abnormal_nociception_after1.85449231
34MP0005310_abnormal_salivary_gland1.84988274
35MP0002405_respiratory_system_inflammati1.81642878
36MP0003448_altered_tumor_morphology1.81369581
37MP0002398_abnormal_bone_marrow1.79384493
38* MP0000716_abnormal_immune_system1.77929869
39MP0010155_abnormal_intestine_physiology1.72911359
40MP0002877_abnormal_melanocyte_morpholog1.63876809
41MP0001845_abnormal_inflammatory_respons1.63508171
42MP0001853_heart_inflammation1.60745442
43MP0009333_abnormal_splenocyte_physiolog1.59847012
44MP0002009_preneoplasia1.58803683
45MP0004947_skin_inflammation1.57567378
46MP0001873_stomach_inflammation1.52820376
47MP0003119_abnormal_digestive_system1.51959752
48MP0004782_abnormal_surfactant_physiolog1.45139170
49MP0008469_abnormal_protein_level1.44339382
50MP0009764_decreased_sensitivity_to1.42170753
51* MP0002429_abnormal_blood_cell1.38950113
52MP0005464_abnormal_platelet_physiology1.37809524
53MP0003300_gastrointestinal_ulcer1.37514046
54MP0001533_abnormal_skeleton_physiology1.37103366
55MP0002722_abnormal_immune_system1.30371811
56MP0005379_endocrine/exocrine_gland_phen1.29770310
57MP0001879_abnormal_lymphatic_vessel1.28490764
58MP0001984_abnormal_olfaction1.26895949
59MP0000689_abnormal_spleen_morphology1.26740343
60MP0008872_abnormal_physiological_respon1.25621133
61MP0008995_early_reproductive_senescence1.24269537
62MP0002277_abnormal_respiratory_mucosa1.20037816
63MP0000372_irregular_coat_pigmentation1.19877420
64MP0001958_emphysema1.16885864
65MP0000858_altered_metastatic_potential1.16291732
66MP0005076_abnormal_cell_differentiation1.14931871
67MP0003806_abnormal_nucleotide_metabolis1.13808403
68MP0001881_abnormal_mammary_gland1.12419271
69MP0005397_hematopoietic_system_phenotyp1.11862305
70MP0001545_abnormal_hematopoietic_system1.11862305
71MP0003303_peritoneal_inflammation1.10460260
72MP0003091_abnormal_cell_migration1.09301330
73MP0005623_abnormal_meninges_morphology1.07811394
74MP0004133_heterotaxia1.07145639
75MP0003566_abnormal_cell_adhesion0.97425987
76MP0000703_abnormal_thymus_morphology0.96931622
77MP0002998_abnormal_bone_remodeling0.94612875
78MP0004957_abnormal_blastocyst_morpholog0.94024361
79MP0010307_abnormal_tumor_latency0.92153076
80MP0000343_altered_response_to0.91933396
81MP0000249_abnormal_blood_vessel0.91228083
82MP0004264_abnormal_extraembryonic_tissu0.88629224
83MP0002933_joint_inflammation0.87947397
84MP0009763_increased_sensitivity_to0.85955631
85MP0001663_abnormal_digestive_system0.84248149
86MP0003172_abnormal_lysosome_physiology0.83677625
87MP0003786_premature_aging0.82409760
88MP0001968_abnormal_touch/_nociception0.81909126
89MP0002396_abnormal_hematopoietic_system0.81359233
90MP0003567_abnormal_fetal_cardiomyocyte0.80322035
91MP0010094_abnormal_chromosome_stability0.80240993
92MP0004381_abnormal_hair_follicle0.78472056
93MP0003866_abnormal_defecation0.76879537
94MP0005084_abnormal_gallbladder_morpholo0.76775409
95MP0005075_abnormal_melanosome_morpholog0.75790555
96MP0003453_abnormal_keratinocyte_physiol0.75305294
97MP0010352_gastrointestinal_tract_polyps0.74721947
98MP0004808_abnormal_hematopoietic_stem0.74464747
99MP0003075_altered_response_to0.74018319
100MP0003186_abnormal_redox_activity0.73551593
101MP0005167_abnormal_blood-brain_barrier0.70875108
102MP0000767_abnormal_smooth_muscle0.70633828
103MP0000465_gastrointestinal_hemorrhage0.70176653
104MP0002136_abnormal_kidney_physiology0.69538966
105MP0003828_pulmonary_edema0.69498804
106MP0002132_abnormal_respiratory_system0.69494188
107MP0008057_abnormal_DNA_replication0.68451279
108MP0001919_abnormal_reproductive_system0.68104134
109MP0010368_abnormal_lymphatic_system0.67852085
110MP0003943_abnormal_hepatobiliary_system0.66486317
111MP0000627_abnormal_mammary_gland0.65208818
112MP0000613_abnormal_salivary_gland0.63581930
113MP0005647_abnormal_sex_gland0.62918692
114MP0002332_abnormal_exercise_endurance0.62807399
115MP0001851_eye_inflammation0.62536957
116MP0002102_abnormal_ear_morphology0.62245192
117MP0003191_abnormal_cellular_cholesterol0.61892770
118MP0000470_abnormal_stomach_morphology0.60973792
119MP0002693_abnormal_pancreas_physiology0.60869730
120MP0009765_abnormal_xenobiotic_induced0.60355464
121MP0003221_abnormal_cardiomyocyte_apopto0.60339115
122MP0002876_abnormal_thyroid_physiology0.59948315
123MP0002139_abnormal_hepatobiliary_system0.58508506
124MP0002295_abnormal_pulmonary_circulatio0.57020109
125MP0002928_abnormal_bile_duct0.56874048
126MP0003045_fibrosis0.56842812
127MP0005381_digestive/alimentary_phenotyp0.56580391
128MP0002019_abnormal_tumor_incidence0.56405639
129MP0005380_embryogenesis_phenotype0.55722000
130MP0001672_abnormal_embryogenesis/_devel0.55722000
131MP0008877_abnormal_DNA_methylation0.55519528
132MP0006054_spinal_hemorrhage0.54855414
133MP0000609_abnormal_liver_physiology0.54470574
134MP0005166_decreased_susceptibility_to0.53975227
135MP0005058_abnormal_lysosome_morphology0.53713173
136MP0005390_skeleton_phenotype0.53462122
137MP0009278_abnormal_bone_marrow0.53215906
138MP0005220_abnormal_exocrine_pancreas0.52968422
139MP0008873_increased_physiological_sensi0.52504688

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)6.36887700
2Retrobulbar optic neuritis (HP:0100654)6.36887700
3Orchitis (HP:0100796)6.06702715
4Myositis (HP:0100614)6.01427213
5Increased IgM level (HP:0003496)5.83594074
6Autoimmune thrombocytopenia (HP:0001973)4.76260398
7Eczematoid dermatitis (HP:0000976)4.54890920
8Elevated erythrocyte sedimentation rate (HP:0003565)4.45403270
9Chronic otitis media (HP:0000389)4.42342893
10Nasal polyposis (HP:0100582)4.08949937
11Abnormality of the nasal mucosa (HP:0000433)4.05867776
12Vasculitis (HP:0002633)4.05167177
13Keratoconjunctivitis sicca (HP:0001097)4.03743524
14Abnormality of macrophages (HP:0004311)4.00310734
15Stomatitis (HP:0010280)3.98418841
16Keratoconjunctivitis (HP:0001096)3.90637616
17Abnormality of T cell number (HP:0011839)3.87305344
18Arterial thrombosis (HP:0004420)3.81818594
19Interstitial pulmonary disease (HP:0006530)3.80748774
20Gonadal dysgenesis (HP:0000133)3.80678525
21Recurrent fungal infections (HP:0002841)3.78115389
22Pulmonary infiltrates (HP:0002113)3.77786368
23Abnormality of the fetal cardiovascular system (HP:0010948)3.73021039
24Abnormal umbilical cord blood vessels (HP:0011403)3.73021039
25Single umbilical artery (HP:0001195)3.73021039
26Recurrent bacterial skin infections (HP:0005406)3.71335111
27Recurrent abscess formation (HP:0002722)3.68694716
28Joint swelling (HP:0001386)3.64683650
29Hypergammaglobulinemia (HP:0010702)3.57019297
30Congenital malformation of the right heart (HP:0011723)3.51817481
31Double outlet right ventricle (HP:0001719)3.51817481
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.47661118
33Encephalitis (HP:0002383)3.47163394
34Recurrent viral infections (HP:0004429)3.45357984
35Eosinophilia (HP:0001880)3.38144744
36Gastrointestinal infarctions (HP:0005244)3.35142786
37Abnormality of abdominal situs (HP:0011620)3.29922582
38Abdominal situs inversus (HP:0003363)3.29922582
39Recurrent bronchitis (HP:0002837)3.23369244
40Septo-optic dysplasia (HP:0100842)3.22281049
41Autoimmune hemolytic anemia (HP:0001890)3.21145024
42Thrombocytosis (HP:0001894)3.19142981
43Spontaneous hematomas (HP:0007420)3.17075499
44Hemoptysis (HP:0002105)3.15012852
45Fused cervical vertebrae (HP:0002949)3.14738223
46Mediastinal lymphadenopathy (HP:0100721)3.13037128
47Asplenia (HP:0001746)3.08211196
48Anal stenosis (HP:0002025)3.07415456
49Oligodactyly (hands) (HP:0001180)3.07283141
50Abnormality of B cell number (HP:0010975)2.97066281
51T lymphocytopenia (HP:0005403)2.92592227
52Recurrent gram-negative bacterial infections (HP:0005420)2.91689729
53Abnormality of the parathyroid morphology (HP:0011766)2.91552747
54Meningitis (HP:0001287)2.90407919
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.88682120
56Tetraparesis (HP:0002273)2.88474433
57Granulocytopenia (HP:0001913)2.88305052
58Abnormal pancreas size (HP:0012094)2.84390255
59Abnormality of eosinophils (HP:0001879)2.82587902
60Leukocytosis (HP:0001974)2.82489333
61Abnormality of T cells (HP:0002843)2.79005169
62Intestinal atresia (HP:0011100)2.78696414
63Absent radius (HP:0003974)2.78622740
64Hypoproteinemia (HP:0003075)2.77351029
65Osteolytic defects of the hand bones (HP:0009699)2.74385537
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.74385537
67Lymphopenia (HP:0001888)2.74252316
68Chronic sinusitis (HP:0011109)2.65428172
69Carpal bone hypoplasia (HP:0001498)2.64780963
70Recurrent skin infections (HP:0001581)2.64631974
71Abnormality of T cell physiology (HP:0011840)2.63693938
72Hematochezia (HP:0002573)2.62922510
73Vertebral compression fractures (HP:0002953)2.60722303
74Pulmonary embolism (HP:0002204)2.59590225
75Horseshoe kidney (HP:0000085)2.59097840
76Anorexia (HP:0002039)2.58659314
77Aplasia involving forearm bones (HP:0009822)2.58594156
78Absent forearm bone (HP:0003953)2.58594156
79IgA deficiency (HP:0002720)2.57171895
80Fatigue (HP:0012378)2.56584034
81Chin dimple (HP:0010751)2.54195973
82Hypochromic anemia (HP:0001931)2.53560388
83Esophageal varix (HP:0002040)2.49515008
84Basal ganglia calcification (HP:0002135)2.48124842
85Porencephaly (HP:0002132)2.47513460
86Gingival bleeding (HP:0000225)2.47210735
87Cleft eyelid (HP:0000625)2.46898469
88Amaurosis fugax (HP:0100576)2.46831618
89Aqueductal stenosis (HP:0002410)2.44172924
90IgG deficiency (HP:0004315)2.43294843
91Recurrent cutaneous fungal infections (HP:0011370)2.42493682
92Chronic mucocutaneous candidiasis (HP:0002728)2.42493682
93Polycythemia (HP:0001901)2.42377625
94Gangrene (HP:0100758)2.41482352
95Increased IgE level (HP:0003212)2.37573933
96Periodontitis (HP:0000704)2.37222054
97Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.36376904
98Abnormality of the pericardium (HP:0001697)2.35808493
99Short middle phalanx of the 5th finger (HP:0004220)2.34890752
100B lymphocytopenia (HP:0010976)2.30892232
101Increased serum ferritin (HP:0003281)2.29728573
102Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.26895237
103Thrombophlebitis (HP:0004418)2.25969695
104Hypoplastic pelvis (HP:0008839)2.21503941
105Aplasia/hypoplasia of the humerus (HP:0006507)2.21300496
106Chronic diarrhea (HP:0002028)2.20683059
107Chest pain (HP:0100749)2.19753670
108Hemiplegia (HP:0002301)2.18040692
109Cerebral ischemia (HP:0002637)2.16325885
110Agammaglobulinemia (HP:0004432)2.16241025
111Peritonitis (HP:0002586)2.14239807
112Arthralgia (HP:0002829)2.14069535
113Severe combined immunodeficiency (HP:0004430)2.14002979
114Inflammation of the large intestine (HP:0002037)2.13905611
115Alveolar cell carcinoma (HP:0006519)2.13269365
116Progressive inability to walk (HP:0002505)2.12525143
117Amelogenesis imperfecta (HP:0000705)2.12303918
118Abnormality of proline metabolism (HP:0010907)2.11132937
119Hydroxyprolinuria (HP:0003080)2.11132937
120Thyroiditis (HP:0100646)2.11108831
121Abnormality of the umbilical cord (HP:0010881)2.10954786
122Aplasia/Hypoplasia of the fovea (HP:0008060)2.10761582
123Hypoplasia of the fovea (HP:0007750)2.10761582
124Abolished electroretinogram (ERG) (HP:0000550)2.08710849
125Abnormality of cells of the lymphoid lineage (HP:0012140)2.08442014
126Vertigo (HP:0002321)2.07415841
127Abnormality of the common coagulation pathway (HP:0010990)2.06311061
128Cellulitis (HP:0100658)2.05575367
129Emphysema (HP:0002097)2.05487148
130Colitis (HP:0002583)2.04742093
131Hypomagnesemia (HP:0002917)2.04536213
132Panhypogammaglobulinemia (HP:0003139)2.03927104
133Gingivitis (HP:0000230)2.03716256
134Abnormality of the prostate (HP:0008775)2.03580780
135Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.02721846
136Myocardial infarction (HP:0001658)2.02203456
137Deep palmar crease (HP:0006191)2.01405223
138Intrahepatic cholestasis (HP:0001406)1.99874165
139Gonadotropin excess (HP:0000837)1.99677573
140Neoplasm of the tracheobronchial system (HP:0100552)1.99218329
141Abnormality of the phalanges of the 5th finger (HP:0004213)1.98725306
142Bronchitis (HP:0012387)1.98432134
143Abnormality of the pleura (HP:0002103)1.98080641
144Osteomyelitis (HP:0002754)1.97658445
145Polyneuropathy (HP:0001271)1.97455203
146Adactyly (HP:0009776)1.96766649
147Hypoalphalipoproteinemia (HP:0003233)1.96650562
148Gastrointestinal inflammation (HP:0004386)1.96342798
149Urticaria (HP:0001025)1.96252810
150Epistaxis (HP:0000421)1.96178540
151Labial hypoplasia (HP:0000066)1.95998891
152Facial diplegia (HP:0001349)1.95990455
153Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94604665
154Keratitis (HP:0000491)1.93893875
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93610509
156Cellular immunodeficiency (HP:0005374)1.93389243
157Abnormality of iron homeostasis (HP:0011031)1.89418834
158Oligodactyly (HP:0012165)1.85085322
159Abnormality of the fovea (HP:0000493)1.83177369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.84625582
2ACVR1B5.07770574
3JAK33.88858374
4TBK13.78077576
5PBK3.65269110
6TRIM283.50348157
7TXK3.29063158
8EIF2AK33.19653937
9BMPR1B3.15354536
10IKBKB3.14309463
11TYK23.00937090
12JAK12.93671999
13IKBKE2.84181457
14ERBB42.67260750
15EPHB12.64453059
16MAP3K132.62842120
17CHUK2.15036865
18MST42.10281419
19BMPR22.02640088
20MAP4K12.02399367
21IRAK41.85138274
22MKNK21.80714157
23KIT1.79027627
24FGFR41.74403038
25PDK21.67420779
26EPHA31.61031819
27FGFR31.60533898
28PLK41.57760751
29ZAP701.54269780
30TESK11.46430242
31BCR1.45954667
32PIM21.44616898
33PTK61.40113926
34EIF2AK11.37876536
35KDR1.37094207
36TAOK31.34109303
37RIPK41.33958146
38TNIK1.33639618
39WNK31.30650569
40SYK1.29062422
41BTK1.28065408
42PIM11.26319245
43FGR1.24688005
44IRAK31.22199110
45MAP3K91.22193226
46PLK21.20984405
47BMX1.20915228
48CSK1.20297438
49BRSK21.16034404
50SCYL21.13863521
51JAK21.11905121
52LCK1.09819358
53FLT31.08899256
54IRAK21.08062291
55MKNK11.07536822
56CSF1R1.05166433
57NLK1.03493379
58GRK71.00403139
59TIE10.97145635
60TEC0.96468277
61TGFBR20.93804660
62ITK0.92485697
63BLK0.91574759
64RIPK10.91509839
65ADRBK20.89758752
66NEK90.89724463
67STK100.89325055
68LRRK20.88088345
69GRK10.86665765
70PKN10.83818491
71RPS6KA40.81459515
72PRKCQ0.80976227
73MAPKAPK20.80015746
74HCK0.79495203
75MELK0.79434045
76TAF10.78620031
77EIF2AK20.75296902
78PAK40.73259066
79SIK30.71908057
80STK240.69516309
81PRKD30.68984802
82NUAK10.67450135
83VRK20.65590335
84MAP2K60.63573927
85TRPM70.62807004
86BRD40.60190064
87LYN0.59892273
88INSRR0.58955533
89ERN10.57500034
90GSK3A0.55731845
91DMPK0.53619454
92NEK10.53003482
93SRPK10.52639604
94IRAK10.52418608
95TTN0.52402449
96STK30.51686983
97TGFBR10.50936923
98ABL10.50561134
99ZAK0.49938465
100DAPK20.49391556
101CDK40.48655389
102PRKCD0.47459434
103FER0.47440691
104SIK20.45328627
105PTK2B0.45230022
106ABL20.45060452
107FES0.44667206
108EGFR0.44146295
109RPS6KA10.43560601
110CDK60.42989181
111PLK30.42538741
112STK40.42442169
113WEE10.41824940
114TNK20.41227205
115LIMK10.39047097
116MAP3K10.38559381
117IGF1R0.37932663
118BCKDK0.37710963
119MAP3K120.36045377
120INSR0.35077416
121MAP3K80.34819264
122FGFR10.34208878
123RAF10.33512649
124MARK30.33322938
125PTK20.33195660
126OXSR10.32527387
127MOS0.31815455
128ADRBK10.31525110
129RET0.30937808
130ARAF0.30920978
131MAP3K20.29884042
132DAPK10.29379589
133MAP2K30.28346634
134HIPK20.28240462
135ERBB30.28213055
136MATK0.28112462
137PDGFRB0.27950658
138RPS6KA50.27907953
139FRK0.27815809
140ALK0.25681057
141TLK10.23155295
142PKN20.21857966
143TSSK60.21823713

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053305.92745027
2Graft-versus-host disease_Homo sapiens_hsa053325.85642907
3Autoimmune thyroid disease_Homo sapiens_hsa053204.01548659
4Type I diabetes mellitus_Homo sapiens_hsa049403.75954725
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.86592267
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.46350958
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19212898
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17727326
9Measles_Homo sapiens_hsa051622.17645985
10Viral myocarditis_Homo sapiens_hsa054162.15743031
11Leishmaniasis_Homo sapiens_hsa051402.10316324
12Antigen processing and presentation_Homo sapiens_hsa046122.00025757
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98045326
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89224036
15TNF signaling pathway_Homo sapiens_hsa046681.88457011
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86659652
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83615085
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76484652
19Steroid biosynthesis_Homo sapiens_hsa001001.76223134
20Primary immunodeficiency_Homo sapiens_hsa053401.70087086
21Toxoplasmosis_Homo sapiens_hsa051451.67940915
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.64924237
23Malaria_Homo sapiens_hsa051441.57751395
24Apoptosis_Homo sapiens_hsa042101.57309778
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56503230
26Osteoclast differentiation_Homo sapiens_hsa043801.53012217
27Influenza A_Homo sapiens_hsa051641.47226025
28Legionellosis_Homo sapiens_hsa051341.43960112
29Rheumatoid arthritis_Homo sapiens_hsa053231.39357145
30Herpes simplex infection_Homo sapiens_hsa051681.33511462
31Pertussis_Homo sapiens_hsa051331.33207467
32Chemokine signaling pathway_Homo sapiens_hsa040621.31378475
33Basal transcription factors_Homo sapiens_hsa030221.28961301
34African trypanosomiasis_Homo sapiens_hsa051431.26101538
35Shigellosis_Homo sapiens_hsa051311.25235627
36Protein export_Homo sapiens_hsa030601.23800774
37T cell receptor signaling pathway_Homo sapiens_hsa046601.23112197
38B cell receptor signaling pathway_Homo sapiens_hsa046621.18466377
39Non-homologous end-joining_Homo sapiens_hsa034501.13902524
40Asthma_Homo sapiens_hsa053101.10620340
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07475931
42Hepatitis B_Homo sapiens_hsa051611.03614120
43Salmonella infection_Homo sapiens_hsa051320.98594480
44Tuberculosis_Homo sapiens_hsa051520.97709941
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.94064963
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92742731
47Acute myeloid leukemia_Homo sapiens_hsa052210.92159764
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91442122
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90724530
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87152083
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87096148
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86185431
53Prolactin signaling pathway_Homo sapiens_hsa049170.85725910
54RNA degradation_Homo sapiens_hsa030180.83173694
55Hematopoietic cell lineage_Homo sapiens_hsa046400.80499217
56Staphylococcus aureus infection_Homo sapiens_hsa051500.80050857
57Hepatitis C_Homo sapiens_hsa051600.79011679
58Small cell lung cancer_Homo sapiens_hsa052220.78223739
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76879337
60Butanoate metabolism_Homo sapiens_hsa006500.75428059
61Proteasome_Homo sapiens_hsa030500.71251425
62Chronic myeloid leukemia_Homo sapiens_hsa052200.68942783
63Epstein-Barr virus infection_Homo sapiens_hsa051690.65830497
64TGF-beta signaling pathway_Homo sapiens_hsa043500.63776438
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62265396
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61499423
67Propanoate metabolism_Homo sapiens_hsa006400.56993979
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56916102
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56053478
70Olfactory transduction_Homo sapiens_hsa047400.53649277
71Pancreatic cancer_Homo sapiens_hsa052120.52805738
72HTLV-I infection_Homo sapiens_hsa051660.52055919
73Platelet activation_Homo sapiens_hsa046110.51493715
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51303584
75Viral carcinogenesis_Homo sapiens_hsa052030.51097678
76p53 signaling pathway_Homo sapiens_hsa041150.47350393
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46737913
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46680267
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.45981635
80* Amoebiasis_Homo sapiens_hsa051460.45409401
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.38904692
82Peroxisome_Homo sapiens_hsa041460.38893737
83VEGF signaling pathway_Homo sapiens_hsa043700.35135039
84Homologous recombination_Homo sapiens_hsa034400.34958341
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34063066
86Glutathione metabolism_Homo sapiens_hsa004800.33470385
87Phagosome_Homo sapiens_hsa041450.33257266
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33190742
89Proteoglycans in cancer_Homo sapiens_hsa052050.31510946
90Fanconi anemia pathway_Homo sapiens_hsa034600.30372401
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30037024
92Focal adhesion_Homo sapiens_hsa045100.29922772
93RNA transport_Homo sapiens_hsa030130.29795096
94Phenylalanine metabolism_Homo sapiens_hsa003600.28236534
95HIF-1 signaling pathway_Homo sapiens_hsa040660.28065856
96Prion diseases_Homo sapiens_hsa050200.27462747
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26869962
98Wnt signaling pathway_Homo sapiens_hsa043100.26816192
99MicroRNAs in cancer_Homo sapiens_hsa052060.26794904
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25952177
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25826294
102Adherens junction_Homo sapiens_hsa045200.24023187
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22347618
104Tryptophan metabolism_Homo sapiens_hsa003800.21913659
105Insulin resistance_Homo sapiens_hsa049310.21660185
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20735631
107MAPK signaling pathway_Homo sapiens_hsa040100.19856473
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19527839
109Pyruvate metabolism_Homo sapiens_hsa006200.19324339
110Collecting duct acid secretion_Homo sapiens_hsa049660.19280455
111Endocytosis_Homo sapiens_hsa041440.17615229
112Notch signaling pathway_Homo sapiens_hsa043300.17396412
113Ether lipid metabolism_Homo sapiens_hsa005650.16885113
114Lysosome_Homo sapiens_hsa041420.15362116
115Pathways in cancer_Homo sapiens_hsa052000.14602954
116FoxO signaling pathway_Homo sapiens_hsa040680.14219656
117mRNA surveillance pathway_Homo sapiens_hsa030150.13954817
118Caffeine metabolism_Homo sapiens_hsa002320.13899403
119Prostate cancer_Homo sapiens_hsa052150.13650024
120Renal cell carcinoma_Homo sapiens_hsa052110.12009893
121Mismatch repair_Homo sapiens_hsa034300.11196637
122Type II diabetes mellitus_Homo sapiens_hsa049300.10339116
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08949394
124Fatty acid metabolism_Homo sapiens_hsa012120.08365152
125Complement and coagulation cascades_Homo sapiens_hsa046100.08234226
126Cell cycle_Homo sapiens_hsa041100.08232883
127Non-small cell lung cancer_Homo sapiens_hsa052230.07891424
128Fatty acid elongation_Homo sapiens_hsa000620.07843232
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07605623
130Ras signaling pathway_Homo sapiens_hsa040140.06519725
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06121852
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03773776
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.03336306
134Systemic lupus erythematosus_Homo sapiens_hsa053220.03054452
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.02292628
136Rap1 signaling pathway_Homo sapiens_hsa040150.01507078
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.01109686

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »