SERPIND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.58977533
2L-phenylalanine catabolic process (GO:0006559)7.58977533
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.24476446
4L-phenylalanine metabolic process (GO:0006558)7.24476446
5aromatic amino acid family catabolic process (GO:0009074)6.81789209
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.40306301
7tryptophan catabolic process (GO:0006569)6.13394619
8indole-containing compound catabolic process (GO:0042436)6.13394619
9indolalkylamine catabolic process (GO:0046218)6.13394619
10kynurenine metabolic process (GO:0070189)6.02784389
11bile acid biosynthetic process (GO:0006699)5.96599090
12regulation of plasminogen activation (GO:0010755)5.84909962
13intestinal cholesterol absorption (GO:0030299)5.82367632
14glyoxylate metabolic process (GO:0046487)5.82082040
15tryptophan metabolic process (GO:0006568)5.77944532
16negative regulation of fibrinolysis (GO:0051918)5.77899797
17urea metabolic process (GO:0019627)5.67879628
18urea cycle (GO:0000050)5.67879628
19high-density lipoprotein particle remodeling (GO:0034375)5.66861226
20regulation of fibrinolysis (GO:0051917)5.56585491
21alpha-linolenic acid metabolic process (GO:0036109)5.56380589
22protein carboxylation (GO:0018214)5.45701981
23peptidyl-glutamic acid carboxylation (GO:0017187)5.45701981
24regulation of protein activation cascade (GO:2000257)5.43650168
25complement activation, alternative pathway (GO:0006957)5.43193616
26sulfur amino acid catabolic process (GO:0000098)5.35451863
27cysteine metabolic process (GO:0006534)5.34428659
28exogenous drug catabolic process (GO:0042738)5.24549078
29nitrogen cycle metabolic process (GO:0071941)5.21898385
30serine family amino acid catabolic process (GO:0009071)5.10046062
31bile acid metabolic process (GO:0008206)5.09951316
32regulation of complement activation (GO:0030449)5.07279967
33epoxygenase P450 pathway (GO:0019373)5.03543752
34regulation of apoptotic cell clearance (GO:2000425)4.99347653
35reverse cholesterol transport (GO:0043691)4.99052753
36aromatic amino acid family metabolic process (GO:0009072)4.95001275
37protein-lipid complex subunit organization (GO:0071825)4.93684030
38regulation of cholesterol esterification (GO:0010872)4.93244711
39negative regulation of protein activation cascade (GO:2000258)4.91065194
40negative regulation of blood coagulation (GO:0030195)4.87809773
41negative regulation of hemostasis (GO:1900047)4.87809773
42protein-lipid complex remodeling (GO:0034368)4.87046616
43macromolecular complex remodeling (GO:0034367)4.87046616
44plasma lipoprotein particle remodeling (GO:0034369)4.87046616
45regulation of triglyceride catabolic process (GO:0010896)4.85072292
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84104471
47tyrosine metabolic process (GO:0006570)4.80489029
48homocysteine metabolic process (GO:0050667)4.76160680
49triglyceride homeostasis (GO:0070328)4.64797842
50acylglycerol homeostasis (GO:0055090)4.64797842
51phospholipid efflux (GO:0033700)4.64053860
52alpha-amino acid catabolic process (GO:1901606)4.63600904
53positive regulation of blood coagulation (GO:0030194)4.63233866
54positive regulation of hemostasis (GO:1900048)4.63233866
55amino-acid betaine metabolic process (GO:0006577)4.58382281
56negative regulation of sterol transport (GO:0032372)4.57282155
57negative regulation of cholesterol transport (GO:0032375)4.57282155
58lysine catabolic process (GO:0006554)4.56297927
59lysine metabolic process (GO:0006553)4.56297927
60plasma lipoprotein particle clearance (GO:0034381)4.49302535
61cellular ketone body metabolic process (GO:0046950)4.47425346
62negative regulation of coagulation (GO:0050819)4.47322310
63glycine metabolic process (GO:0006544)4.42944648
64bile acid and bile salt transport (GO:0015721)4.41744224
65regulation of humoral immune response (GO:0002920)4.37405695
66positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.36212524
67imidazole-containing compound metabolic process (GO:0052803)4.35530702
68indolalkylamine metabolic process (GO:0006586)4.34975970
69coenzyme catabolic process (GO:0009109)4.33724950
70cholesterol efflux (GO:0033344)4.32262438
71omega-hydroxylase P450 pathway (GO:0097267)4.31121306
72negative regulation of wound healing (GO:0061045)4.30014963
73cellular amino acid catabolic process (GO:0009063)4.26795738
74cellular biogenic amine catabolic process (GO:0042402)4.25965643
75amine catabolic process (GO:0009310)4.25965643
76positive regulation of coagulation (GO:0050820)4.25475042
77cellular glucuronidation (GO:0052695)4.24344179
78glutamate metabolic process (GO:0006536)4.24170170
79acute-phase response (GO:0006953)4.21156349
80serine family amino acid metabolic process (GO:0009069)4.18327654
81benzene-containing compound metabolic process (GO:0042537)4.11510889
82plasma lipoprotein particle assembly (GO:0034377)4.09882774
83fibrinolysis (GO:0042730)4.09764744
84low-density lipoprotein particle remodeling (GO:0034374)4.08542119
85serine family amino acid biosynthetic process (GO:0009070)4.06487943
86ethanol oxidation (GO:0006069)4.06348149
87dicarboxylic acid biosynthetic process (GO:0043650)4.05488249
88cellular modified amino acid catabolic process (GO:0042219)4.04497117
89arginine metabolic process (GO:0006525)4.01745659
90negative regulation of complement activation (GO:0045916)4.01402146
91aldehyde catabolic process (GO:0046185)4.00516692
92lipoprotein metabolic process (GO:0042157)3.99248034
93blood coagulation, intrinsic pathway (GO:0007597)3.96481895
94ethanol metabolic process (GO:0006067)3.96140330
95ketone body metabolic process (GO:1902224)3.87409948
96drug catabolic process (GO:0042737)3.87392526
97positive regulation of lipoprotein lipase activity (GO:0051006)3.84220077
98positive regulation of triglyceride lipase activity (GO:0061365)3.84220077
99sterol transport (GO:0015918)3.82428218
100cholesterol transport (GO:0030301)3.82428218
101phospholipid homeostasis (GO:0055091)3.81286003
102complement activation, classical pathway (GO:0006958)3.80670342
103cofactor catabolic process (GO:0051187)3.80641663
104very-low-density lipoprotein particle assembly (GO:0034379)3.79884614
105protein activation cascade (GO:0072376)3.78461794
106cholesterol homeostasis (GO:0042632)3.78261848
107complement activation (GO:0006956)3.77737847
108positive regulation of lipid catabolic process (GO:0050996)3.77397586
109intestinal absorption (GO:0050892)3.76811831
110uronic acid metabolic process (GO:0006063)3.76299886
111glucuronate metabolic process (GO:0019585)3.76299886
112negative regulation of lipase activity (GO:0060192)3.74213792
113positive regulation of fatty acid biosynthetic process (GO:0045723)3.72935409
114organic acid catabolic process (GO:0016054)3.72532534
115carboxylic acid catabolic process (GO:0046395)3.72532534
116sterol homeostasis (GO:0055092)3.71888892
117plasma lipoprotein particle organization (GO:0071827)3.70993933
118cytolysis (GO:0019835)3.69481507
119regulation of bile acid biosynthetic process (GO:0070857)3.68925098
120protein-lipid complex assembly (GO:0065005)3.67640724
121short-chain fatty acid metabolic process (GO:0046459)3.64136201
122acetyl-CoA metabolic process (GO:0006084)3.62759960
123drug metabolic process (GO:0017144)3.61999537
124regulation of cholesterol homeostasis (GO:2000188)3.59143810
125proline metabolic process (GO:0006560)3.56226330
126opsonization (GO:0008228)3.52808938
127NAD biosynthetic process (GO:0009435)3.52305882
128positive regulation of extracellular matrix organization (GO:1903055)3.49251316
129positive regulation of steroid metabolic process (GO:0045940)3.43657263
130negative regulation of lipid transport (GO:0032369)3.38534291
131regulation of cholesterol biosynthetic process (GO:0045540)3.37347179
132regulation of lipoprotein particle clearance (GO:0010984)3.31924335
133peptidyl-glutamic acid modification (GO:0018200)3.28977133
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.28521323
135diacylglycerol metabolic process (GO:0046339)3.28308679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.38025787
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19510549
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07959052
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.52289793
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28787207
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.06975721
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.78042103
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06850761
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02785374
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07299708
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9576021
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98362963
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96849256
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91892788
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.63900481
16HTT_18923047_ChIP-ChIP_STHdh_Human1.61045606
17CLOCK_20551151_ChIP-Seq_293T_Human1.52509370
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.51240409
19GATA1_22025678_ChIP-Seq_K562_Human1.49588587
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.41342933
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38356091
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31127616
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28928845
24* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17326527
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15851903
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15663618
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13141339
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10283648
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.00742411
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00279578
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99492498
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96527538
33AR_21909140_ChIP-Seq_LNCAP_Human0.96053567
34TRIM28_21343339_ChIP-Seq_HEK293_Human0.95266603
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92970210
36SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91934881
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91522666
38NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88840058
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88788257
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85586353
41AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84227561
42GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83871017
43CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83165240
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81680807
45IRF8_22096565_ChIP-ChIP_GC-B_Human0.81639087
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81579006
47SOX2_20726797_ChIP-Seq_SW620_Human0.80663953
48RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80351679
49POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79318848
50* GATA4_25053715_ChIP-Seq_YYC3_Human0.77792435
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77764740
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77690772
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76879561
54KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75842810
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74205339
56RARA_24833708_ChIP-Seq_LIVER_Mouse0.73275789
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73201093
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73058427
59ZNF263_19887448_ChIP-Seq_K562_Human0.72589494
60PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70656326
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70042554
62SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69274180
63CTNNB1_20460455_ChIP-Seq_HCT116_Human0.68501783
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68438536
65NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68438536
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68337015
67ESR2_21235772_ChIP-Seq_MCF-7_Human0.66772431
68TP53_16413492_ChIP-PET_HCT116_Human0.65262529
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.64369857
70SMAD1_18555785_Chip-Seq_ESCs_Mouse0.63654718
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62038858
72RAC3_21632823_ChIP-Seq_H3396_Human0.61668168
73RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61359192
74* RARB_24833708_ChIP-Seq_LIVER_Mouse0.60512575
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60465314
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60362522
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60187727
78CEBPB_22108803_ChIP-Seq_LS180_Human0.57762064
79SOX2_21211035_ChIP-Seq_LN229_Human0.57333558
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57092044
81NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.56389051
82EGR1_19032775_ChIP-ChIP_M12_Human0.56209937
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.55209808
84SOX11_22085726_ChIP-Seq_ESNs_Mouse0.55107698
85FOXA1_25552417_ChIP-Seq_VCAP_Human0.54650773
86ESRRB_18555785_Chip-Seq_ESCs_Mouse0.53729815
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.53589973
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.53523003
89MYC_19915707_ChIP-ChIP_AK7_Human0.52433990
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52378810
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.52360043
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52303918
93TAF15_26573619_Chip-Seq_HEK293_Human0.52085121
94AR_20517297_ChIP-Seq_VCAP_Human0.52076650
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50941663
96* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49962820
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49837797
98ZFX_18555785_Chip-Seq_ESCs_Mouse0.49823032
99CBP_21632823_ChIP-Seq_H3396_Human0.49650277
100GATA3_24758297_ChIP-Seq_MCF-7_Human0.49412151
101RUNX1_27457419_Chip-Seq_LIVER_Mouse0.49287782
102* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.49169642
103SMC4_20622854_ChIP-Seq_HELA_Human0.48765681
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.48437232
105* LXR_22292898_ChIP-Seq_THP-1_Human0.47867738
106STAT1_17558387_ChIP-Seq_HELA_Human0.47641667
107AR_21572438_ChIP-Seq_LNCaP_Human0.47531796
108GATA1_19941826_ChIP-Seq_K562_Human0.47431329
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46983151
110P53_21459846_ChIP-Seq_SAOS-2_Human0.46555985
111* ESET_19884257_ChIP-Seq_ESCs_Mouse0.46362165
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.45529660
113PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45049966
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44708223
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43842727
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.43479910
117TAF2_19829295_ChIP-Seq_ESCs_Human0.42783595
118GATA2_19941826_ChIP-Seq_K562_Human0.42344646
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.41810256
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41332165
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.40991541
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.40765066
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.40576193
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39958777
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39764845
126BCAT_22108803_ChIP-Seq_LS180_Human0.39632270
127GATA6_25053715_ChIP-Seq_YYC3_Human0.38142959
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.37527736
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.37271368
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36760434
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36649172
132LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35751427
133SPI1_26923725_Chip-Seq_HPCs_Mouse0.34929149
134* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.34750832
135NCOR_22424771_ChIP-Seq_293T_Human0.34417155
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.34261193
137ERG_20517297_ChIP-Seq_VCAP_Human0.33865715
138CDX2_22108803_ChIP-Seq_LS180_Human0.33846769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29474337
2MP0005360_urolithiasis7.60188742
3MP0005085_abnormal_gallbladder_physiolo6.45685556
4MP0005365_abnormal_bile_salt6.17378591
5MP0008875_abnormal_xenobiotic_pharmacok5.10102180
6MP0003806_abnormal_nucleotide_metabolis4.30823095
7MP0003252_abnormal_bile_duct3.91795473
8MP0010329_abnormal_lipoprotein_level3.62210012
9MP0009840_abnormal_foam_cell3.30763665
10MP0003122_maternal_imprinting3.14987153
11MP0005083_abnormal_biliary_tract3.12742379
12MP0003195_calcinosis2.84091167
13MP0005332_abnormal_amino_acid2.74619699
14MP0001666_abnormal_nutrient_absorption2.60187625
15MP0003191_abnormal_cellular_cholesterol2.36509494
16MP0000609_abnormal_liver_physiology2.17001794
17MP0004019_abnormal_vitamin_homeostasis2.12763204
18MP0002118_abnormal_lipid_homeostasis2.10739530
19MP0002138_abnormal_hepatobiliary_system1.95481729
20MP0003868_abnormal_feces_composition1.93755209
21MP0005319_abnormal_enzyme/_coenzyme1.82414159
22MP0001764_abnormal_homeostasis1.68272820
23MP0009697_abnormal_copulation1.65100654
24MP0001915_intracranial_hemorrhage1.64577683
25MP0000566_synostosis1.62428000
26MP0005584_abnormal_enzyme/coenzyme_acti1.57676407
27MP0003123_paternal_imprinting1.46013794
28MP0002089_abnormal_postnatal_growth/wei1.42633652
29MP0003011_delayed_dark_adaptation1.42202841
30MP0005451_abnormal_body_composition1.38803284
31MP0003656_abnormal_erythrocyte_physiolo1.35715239
32MP0003186_abnormal_redox_activity1.26498031
33MP0009643_abnormal_urine_homeostasis1.22370480
34MP0003172_abnormal_lysosome_physiology1.22324348
35MP0000598_abnormal_liver_morphology1.18105231
36MP0005647_abnormal_sex_gland1.13558144
37MP0000604_amyloidosis1.13112462
38MP0003705_abnormal_hypodermis_morpholog1.12826074
39MP0002254_reproductive_system_inflammat1.04895894
40MP0009764_decreased_sensitivity_to1.04824081
41MP0009763_increased_sensitivity_to1.03110835
42MP0010368_abnormal_lymphatic_system1.00625718
43MP0005636_abnormal_mineral_homeostasis0.93650772
44MP0008469_abnormal_protein_level0.89436714
45MP0005408_hypopigmentation0.88746933
46MP0005409_darkened_coat_color0.86502918
47* MP0009642_abnormal_blood_homeostasis0.86279062
48MP0004272_abnormal_basement_membrane0.81428335
49MP0006036_abnormal_mitochondrial_physio0.81297086
50MP0005084_abnormal_gallbladder_morpholo0.79913781
51MP0009765_abnormal_xenobiotic_induced0.79419068
52MP0009780_abnormal_chondrocyte_physiolo0.78515981
53MP0006054_spinal_hemorrhage0.77867806
54MP0002078_abnormal_glucose_homeostasis0.77678549
55MP0002876_abnormal_thyroid_physiology0.76525863
56MP0003121_genomic_imprinting0.73991644
57* MP0005376_homeostasis/metabolism_phenot0.73908953
58MP0005220_abnormal_exocrine_pancreas0.73579855
59MP0005670_abnormal_white_adipose0.73530593
60MP0003690_abnormal_glial_cell0.72454564
61MP0003879_abnormal_hair_cell0.70982896
62MP0002971_abnormal_brown_adipose0.70528192
63MP0001661_extended_life_span0.69393089
64MP0004130_abnormal_muscle_cell0.68479107
65MP0005334_abnormal_fat_pad0.67530739
66MP0005535_abnormal_body_temperature0.67095727
67MP0003329_amyloid_beta_deposits0.66860539
68MP0005257_abnormal_intraocular_pressure0.65591319
69MP0009053_abnormal_anal_canal0.65207189
70MP0005266_abnormal_metabolism0.64186469
71MP0000639_abnormal_adrenal_gland0.63157220
72MP0003183_abnormal_peptide_metabolism0.60977760
73MP0003567_abnormal_fetal_cardiomyocyte0.59614458
74MP0002282_abnormal_trachea_morphology0.57985124
75MP0001756_abnormal_urination0.57219657
76MP0006035_abnormal_mitochondrial_morpho0.55900325
77MP0005448_abnormal_energy_balance0.55249549
78MP0003950_abnormal_plasma_membrane0.54626923
79MP0005377_hearing/vestibular/ear_phenot0.50708832
80MP0003878_abnormal_ear_physiology0.50708832
81MP0004264_abnormal_extraembryonic_tissu0.49875045
82MP0003632_abnormal_nervous_system0.49775742
83MP0000920_abnormal_myelination0.49263607
84MP0002909_abnormal_adrenal_gland0.49252404
85MP0002822_catalepsy0.49035028
86MP0005395_other_phenotype0.48871912
87MP0002933_joint_inflammation0.47798514
88MP0003718_maternal_effect0.46997910
89MP0002928_abnormal_bile_duct0.45637074
90MP0005023_abnormal_wound_healing0.45618541
91MP0008874_decreased_physiological_sensi0.45613092
92MP0003638_abnormal_response/metabolism_0.45039491
93MP0008873_increased_physiological_sensi0.44562857
94MP0002136_abnormal_kidney_physiology0.43774279
95MP0004782_abnormal_surfactant_physiolog0.42830396
96MP0001270_distended_abdomen0.42403275
97MP0003075_altered_response_to0.42195835
98MP0001324_abnormal_eye_pigmentation0.42144040
99MP0003436_decreased_susceptibility_to0.41924563
100MP0002837_dystrophic_cardiac_calcinosis0.41669777
101MP0003724_increased_susceptibility_to0.41158170
102MP0003953_abnormal_hormone_level0.40161284
103MP0004381_abnormal_hair_follicle0.40125495
104MP0003943_abnormal_hepatobiliary_system0.40018996
105* MP0005464_abnormal_platelet_physiology0.39360554
106MP0005410_abnormal_fertilization0.39040018
107MP0000003_abnormal_adipose_tissue0.38743763
108MP0005248_abnormal_Harderian_gland0.38700823
109MP0008872_abnormal_physiological_respon0.38545401
110MP0003566_abnormal_cell_adhesion0.38323177
111MP0005166_decreased_susceptibility_to0.38116577
112MP0002938_white_spotting0.37961446
113MP0003115_abnormal_respiratory_system0.37061884
114MP0009672_abnormal_birth_weight0.36898751
115MP0003941_abnormal_skin_development0.36384132
116MP0000579_abnormal_nail_morphology0.34822570
117MP0005666_abnormal_adipose_tissue0.34156493
118MP0003315_abnormal_perineum_morphology0.33630132
119MP0002796_impaired_skin_barrier0.33049768
120MP0006082_CNS_inflammation0.32079232
121MP0001243_abnormal_dermal_layer0.31797809
122MP0009115_abnormal_fat_cell0.31528256
123MP0003631_nervous_system_phenotype0.30961178
124MP0009384_cardiac_valve_regurgitation0.30942654
125MP0000230_abnormal_systemic_arterial0.30690197
126MP0002128_abnormal_blood_circulation0.30660265
127MP0005379_endocrine/exocrine_gland_phen0.30273841
128MP0002168_other_aberrant_phenotype0.29622430
129MP0005076_abnormal_cell_differentiation0.29548902
130MP0002970_abnormal_white_adipose0.28698260
131MP0001853_heart_inflammation0.28491891
132MP0001845_abnormal_inflammatory_respons0.27843351
133MP0001881_abnormal_mammary_gland0.26930304
134* MP0000249_abnormal_blood_vessel0.25879464
135MP0002132_abnormal_respiratory_system0.25091909
136MP0002090_abnormal_vision0.24460601
137MP0005058_abnormal_lysosome_morphology0.23185612
138MP0005167_abnormal_blood-brain_barrier0.22809932
139MP0002060_abnormal_skin_morphology0.22668192

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.41136656
2Intrahepatic cholestasis (HP:0001406)7.38640981
3* Deep venous thrombosis (HP:0002625)7.00243602
4Prolonged partial thromboplastin time (HP:0003645)6.73087851
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.62613884
6Hypobetalipoproteinemia (HP:0003563)6.46424165
7Xanthomatosis (HP:0000991)6.32207513
8Hyperlipoproteinemia (HP:0010980)5.58611343
9Complement deficiency (HP:0004431)5.49655684
10Joint hemorrhage (HP:0005261)4.94622277
11Hypolipoproteinemia (HP:0010981)4.86893181
12Hyperammonemia (HP:0001987)4.60359202
13Abnormality of the common coagulation pathway (HP:0010990)4.57519358
14Epidermoid cyst (HP:0200040)4.51602851
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45703306
16Hyperglycinemia (HP:0002154)4.42000501
17Abnormality of methionine metabolism (HP:0010901)4.27098576
18Hypoalphalipoproteinemia (HP:0003233)4.25537224
19Ketosis (HP:0001946)4.23001266
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.22790976
21Fat malabsorption (HP:0002630)4.17113026
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11098214
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09877122
24Abnormality of complement system (HP:0005339)4.00518613
25Abnormality of serine family amino acid metabolism (HP:0010894)3.90324598
26Abnormality of glycine metabolism (HP:0010895)3.90324598
27Hyperglycinuria (HP:0003108)3.87443499
28Hypoglycemic coma (HP:0001325)3.85723248
29Abnormality of the intrinsic pathway (HP:0010989)3.85061706
30Abnormality of pyrimidine metabolism (HP:0004353)3.79658466
31Conjugated hyperbilirubinemia (HP:0002908)3.78037340
32Hypercholesterolemia (HP:0003124)3.65180602
33Hyperbilirubinemia (HP:0002904)3.39941265
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32746895
35Abnormality of fatty-acid metabolism (HP:0004359)3.28919498
36Steatorrhea (HP:0002570)3.13125467
37Purpura (HP:0000979)3.11415185
38Delayed CNS myelination (HP:0002188)3.11206649
39Hypochromic microcytic anemia (HP:0004840)3.11119670
40Spontaneous abortion (HP:0005268)3.10777192
41Abnormality of serum amino acid levels (HP:0003112)3.06367707
42Hepatocellular carcinoma (HP:0001402)3.02620915
43Abnormality of nucleobase metabolism (HP:0010932)3.01194863
44Ketoacidosis (HP:0001993)2.97081409
45Myocardial infarction (HP:0001658)2.93279091
46Skin nodule (HP:0200036)2.78263575
47Systemic lupus erythematosus (HP:0002725)2.77401038
48Metabolic acidosis (HP:0001942)2.74929800
49Osteomalacia (HP:0002749)2.73325777
50Acanthocytosis (HP:0001927)2.72097482
51Abnormality of purine metabolism (HP:0004352)2.61963062
52Abnormality of carpal bone ossification (HP:0006257)2.58647893
53Arthropathy (HP:0003040)2.57973057
54Lethargy (HP:0001254)2.57950390
55Vascular calcification (HP:0004934)2.57193585
56Dicarboxylic aciduria (HP:0003215)2.54980131
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54980131
58Glomerulonephritis (HP:0000099)2.54305562
59Abnormal gallbladder morphology (HP:0012437)2.52475500
60Hypoglycemic seizures (HP:0002173)2.49317331
61Abnormal tarsal ossification (HP:0008369)2.48572429
62Cholelithiasis (HP:0001081)2.45966753
63Spastic diplegia (HP:0001264)2.43654707
64Cerebral edema (HP:0002181)2.42416419
65Recurrent gram-negative bacterial infections (HP:0005420)2.42276296
66Mitral stenosis (HP:0001718)2.41361091
67Gout (HP:0001997)2.37590898
68Cholecystitis (HP:0001082)2.36982340
69Abnormal gallbladder physiology (HP:0012438)2.36982340
70Amyloidosis (HP:0011034)2.35517130
71Irritability (HP:0000737)2.34366909
72Neonatal onset (HP:0003623)2.32861399
73Gingival bleeding (HP:0000225)2.29175191
74Cardiovascular calcification (HP:0011915)2.27880140
75Broad alveolar ridges (HP:0000187)2.27040173
76Esophageal varix (HP:0002040)2.20971251
77Menorrhagia (HP:0000132)2.20225488
78Malnutrition (HP:0004395)2.19951791
79Pancreatic islet-cell hyperplasia (HP:0004510)2.15282724
80Pancreatitis (HP:0001733)2.14072849
81Poikilocytosis (HP:0004447)2.13812696
82Thrombophlebitis (HP:0004418)2.12362678
83Sensorimotor neuropathy (HP:0007141)2.11710219
84Pulmonary embolism (HP:0002204)2.11640940
85Enlarged kidneys (HP:0000105)2.10663452
86Abnormality of the Achilles tendon (HP:0005109)2.09446539
87Flat acetabular roof (HP:0003180)2.09408320
88Brushfield spots (HP:0001088)2.08684936
89Late onset (HP:0003584)2.05795249
90Small epiphyses (HP:0010585)2.05477700
91Vomiting (HP:0002013)2.04682563
92Abnormality of the gallbladder (HP:0005264)2.04082971
93Increased serum pyruvate (HP:0003542)2.03544828
94Opisthotonus (HP:0002179)2.02548427
95Hyperinsulinemic hypoglycemia (HP:0000825)2.01966320
96Hemorrhage of the eye (HP:0011885)2.00839533
97Generalized aminoaciduria (HP:0002909)1.99178862
98Bifid scrotum (HP:0000048)1.95310330
99Rickets (HP:0002748)1.95109704
100Abnormality of the lumbar spine (HP:0100712)1.93148212
101Abnormality of iron homeostasis (HP:0011031)1.91706456
102Abnormal hand bone ossification (HP:0010660)1.89915103
103Hypophosphatemic rickets (HP:0004912)1.89639241
104Asymmetry of the thorax (HP:0001555)1.89594379
105Abnormality of transition element cation homeostasis (HP:0011030)1.89067561
106Facial shape deformation (HP:0011334)1.87716806
107Potter facies (HP:0002009)1.87716806
108Abnormality of the nasal septum (HP:0000419)1.86462780
109Abnormal ossification of hand bones (HP:0005921)1.86141435
110Epistaxis (HP:0000421)1.85345059
111Vaginal fistula (HP:0004320)1.85293992
112Abnormal cartilage morphology (HP:0002763)1.84717916
113Hepatoblastoma (HP:0002884)1.83548618
114Abnormality of glycolysis (HP:0004366)1.82482553
115Renal cortical cysts (HP:0000803)1.82457260
116Abnormal enzyme/coenzyme activity (HP:0012379)1.82067683
117Abnormality of proline metabolism (HP:0010907)1.81379771
118Hydroxyprolinuria (HP:0003080)1.81379771
119Elevated hepatic transaminases (HP:0002910)1.80574050
120Nephritis (HP:0000123)1.79354579
121Alkalosis (HP:0001948)1.78614814
122Status epilepticus (HP:0002133)1.77356102
123Broad palm (HP:0001169)1.77178746
124Abnormality of vitamin metabolism (HP:0100508)1.74582556
125Reticulocytosis (HP:0001923)1.74239649
126Reduced antithrombin III activity (HP:0001976)1.71213363
127Joint swelling (HP:0001386)1.70877423
128Peritonitis (HP:0002586)1.70133820
129Abnormal delivery (HP:0001787)1.65609896
130Pigmentary retinal degeneration (HP:0001146)1.64826076
131Submucous cleft hard palate (HP:0000176)1.63325397
132Hyperphosphaturia (HP:0003109)1.59906962
133Proximal tubulopathy (HP:0000114)1.57628405
134Fair hair (HP:0002286)1.56881520
135Glycosuria (HP:0003076)1.54827540
136Abnormality of urine glucose concentration (HP:0011016)1.54827540
137Prenatal maternal abnormality (HP:0002686)1.53716211
138Gangrene (HP:0100758)1.53377836
139Retinal atrophy (HP:0001105)1.52417781
140Abnormal foot bone ossification (HP:0010675)1.52098791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.22887632
2FGFR44.63519059
3SIK14.62806210
4ERN14.27969638
5WNK43.29250755
6TAOK33.14360850
7CDK123.07347754
8INSRR3.03429191
9ERBB42.89335522
10MAP2K42.36623486
11TYRO32.27435855
12PKN22.19890284
13MST1R2.15805394
14FGFR12.12273624
15PDGFRA1.98068010
16MAPK111.91981210
17FLT31.90708814
18PIK3CG1.86677858
19AKT31.74059515
20TYK21.73707811
21TRIB31.72855181
22WNK11.69325384
23DAPK21.63193791
24LATS11.59454199
25EIF2AK11.49334022
26ABL21.47502316
27PTK61.46431313
28SIK21.44069145
29FGFR21.43740780
30NEK91.37727166
31FRK1.36076251
32KDR1.30485382
33MAP3K21.26935226
34JAK21.23985751
35MAP3K71.19444298
36PINK11.15124274
37PRKAA21.11680891
38GRK61.07316609
39EEF2K1.06746020
40MAP2K31.06711487
41ERBB21.04425000
42JAK11.02406856
43TBK11.00793373
44DDR21.00378906
45MAP3K141.00069432
46MAPK40.98266866
47MAP3K100.95870237
48NTRK30.94185020
49MET0.94129031
50PRKCZ0.92957340
51EPHB10.91498313
52MAPKAPK30.86573585
53FGR0.85522246
54MAPK120.83974386
55MAP3K30.82397108
56EPHA30.82350899
57CDK70.81816233
58STK38L0.79859060
59SGK10.79630215
60CDK60.79380647
61MAPK150.78478522
62TIE10.77626012
63PRKACG0.77615323
64CSNK1E0.77340569
65MAP3K110.75759484
66RPS6KB10.74369539
67CAMK2G0.74262194
68BCR0.70822081
69CAMK1D0.69902582
70CSK0.69189418
71GSK3A0.68836675
72DYRK1B0.67509570
73PRKAA10.65237903
74CDC42BPA0.63223503
75SGK30.63073784
76MAP2K60.61808389
77RIPK10.58878625
78MAPK70.58469575
79TGFBR20.57660832
80BRD40.56714389
81CSF1R0.56599438
82FGFR30.55794077
83PDK20.55762767
84KSR20.55734008
85PTK20.55681052
86PRKCQ0.55516260
87IRAK30.55310495
88CSNK1D0.53827045
89PDPK10.52266924
90IKBKE0.51878392
91NEK10.51776130
92EPHA40.51348245
93BRSK10.51150932
94CSNK1G10.50892411
95BRSK20.49051664
96PKN10.48608136
97NEK20.47924933
98SGK20.46562470
99GRK10.46549846
100RET0.45476617
101PBK0.45213558
102IGF1R0.44382037
103MATK0.42654145
104SRC0.42648301
105ICK0.42296754
106PRKCG0.42173269
107PRKG10.42100663
108MAP2K10.41878524
109EPHA20.41598896
110MAP3K50.41595459
111NLK0.41582571
112TAOK20.41308823
113CSNK2A20.40857401
114CDK40.39933729
115SGK2230.39054894
116SGK4940.39054894
117MAP3K130.38844289
118RPS6KA30.38647293
119CSNK2A10.34755283
120MTOR0.34398789
121EGFR0.33953019
122MAP3K60.33834401
123PDK10.33316173
124STK390.32119204
125CSNK1G20.31625077
126CDK80.31304977
127CAMK40.31172927
128SMG10.30524183
129PDGFRB0.29653447
130PRKCB0.28801565
131CDK90.28537425
132CSNK1G30.28271885
133NTRK20.28135476
134MAP3K10.27163905
135PRKCA0.26792696
136MELK0.26524721
137MUSK0.25192711
138PAK30.24342453
139CAMK1G0.23276581
140IRAK10.21849895
141PIK3CA0.21614763
142IRAK20.21388488
143ABL10.20927355
144LATS20.20301543
145BMX0.19561790
146PRKACB0.19531506

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53141275
2Nitrogen metabolism_Homo sapiens_hsa009103.70796641
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38243280
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33694743
5Arginine biosynthesis_Homo sapiens_hsa002203.07893667
6* Complement and coagulation cascades_Homo sapiens_hsa046102.77358085
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68256400
8Tryptophan metabolism_Homo sapiens_hsa003802.67705621
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64358944
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56849434
11Fatty acid degradation_Homo sapiens_hsa000712.46634011
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37868053
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21951513
14Butanoate metabolism_Homo sapiens_hsa006502.14976427
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14452087
16Peroxisome_Homo sapiens_hsa041462.05065898
17Chemical carcinogenesis_Homo sapiens_hsa052041.95385493
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93090250
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.93047979
20Propanoate metabolism_Homo sapiens_hsa006401.92250766
21Histidine metabolism_Homo sapiens_hsa003401.91114176
22PPAR signaling pathway_Homo sapiens_hsa033201.84031392
23Staphylococcus aureus infection_Homo sapiens_hsa051501.79992701
24Fatty acid metabolism_Homo sapiens_hsa012121.79816847
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75405627
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.74751236
27Caffeine metabolism_Homo sapiens_hsa002321.73264872
28beta-Alanine metabolism_Homo sapiens_hsa004101.69935040
29Retinol metabolism_Homo sapiens_hsa008301.69603211
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63887198
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63265799
32Selenocompound metabolism_Homo sapiens_hsa004501.57728731
33Phenylalanine metabolism_Homo sapiens_hsa003601.55338063
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49652034
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49493232
36Bile secretion_Homo sapiens_hsa049761.48582071
37Tyrosine metabolism_Homo sapiens_hsa003501.44082602
38Sulfur metabolism_Homo sapiens_hsa009201.37353379
39Fatty acid elongation_Homo sapiens_hsa000621.35848868
40Pyruvate metabolism_Homo sapiens_hsa006201.34964153
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30709884
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26814179
43Steroid biosynthesis_Homo sapiens_hsa001001.24011960
44ABC transporters_Homo sapiens_hsa020101.20907817
45Folate biosynthesis_Homo sapiens_hsa007901.19855819
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19540981
47Fat digestion and absorption_Homo sapiens_hsa049751.18346348
48Carbon metabolism_Homo sapiens_hsa012001.11531570
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03039202
50Vitamin B6 metabolism_Homo sapiens_hsa007501.02675454
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01113046
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.00069953
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.97419024
54Arginine and proline metabolism_Homo sapiens_hsa003300.96382312
55Sulfur relay system_Homo sapiens_hsa041220.92948016
56Vitamin digestion and absorption_Homo sapiens_hsa049770.87233584
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85894359
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82781417
59Lysine degradation_Homo sapiens_hsa003100.79892374
60Other glycan degradation_Homo sapiens_hsa005110.79087951
61One carbon pool by folate_Homo sapiens_hsa006700.76368492
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68530113
63Glycerolipid metabolism_Homo sapiens_hsa005610.66436646
64Glutathione metabolism_Homo sapiens_hsa004800.65301161
65Pentose phosphate pathway_Homo sapiens_hsa000300.56178643
66Fatty acid biosynthesis_Homo sapiens_hsa000610.53293135
67Metabolic pathways_Homo sapiens_hsa011000.45586807
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45101998
69Pertussis_Homo sapiens_hsa051330.44048547
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38613088
71Prion diseases_Homo sapiens_hsa050200.38275401
72N-Glycan biosynthesis_Homo sapiens_hsa005100.34147970
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26059223
74Galactose metabolism_Homo sapiens_hsa000520.24460492
75Linoleic acid metabolism_Homo sapiens_hsa005910.23657059
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23233361
77Insulin resistance_Homo sapiens_hsa049310.22131066
78Fructose and mannose metabolism_Homo sapiens_hsa000510.21079256
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.21060810
80Mineral absorption_Homo sapiens_hsa049780.18245118
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.15680965
82Glucagon signaling pathway_Homo sapiens_hsa049220.08665295
83Sphingolipid metabolism_Homo sapiens_hsa006000.08143631
84AMPK signaling pathway_Homo sapiens_hsa041520.01016400
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2477835
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2398866
87Amoebiasis_Homo sapiens_hsa05146-0.2349438
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2249380
89Ether lipid metabolism_Homo sapiens_hsa00565-0.2211707
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1951462
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1890628
92Renin-angiotensin system_Homo sapiens_hsa04614-0.1881067
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1877273
94Hepatitis C_Homo sapiens_hsa05160-0.1802731
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1644541
96Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1636117
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1626574
98Regulation of autophagy_Homo sapiens_hsa04140-0.1399198
99Lysosome_Homo sapiens_hsa04142-0.1309545
100African trypanosomiasis_Homo sapiens_hsa05143-0.1308777
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1306760
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1227297
103Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1101088
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1093129
105Circadian rhythm_Homo sapiens_hsa04710-0.1074103
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0832637
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0787938
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0661135
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0474168
110ECM-receptor interaction_Homo sapiens_hsa04512-0.0301504

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