SERPINE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endodermal cell differentiation (GO:0035987)5.51160600
2sequestering of extracellular ligand from receptor (GO:0035581)5.48390492
3type B pancreatic cell proliferation (GO:0044342)5.39368937
4protein heterotrimerization (GO:0070208)5.35452739
5collagen fibril organization (GO:0030199)5.18474323
6hemidesmosome assembly (GO:0031581)5.13140816
7dermatan sulfate biosynthetic process (GO:0030208)5.08176781
8chondroitin sulfate catabolic process (GO:0030207)4.99080620
9dermatan sulfate metabolic process (GO:0030205)4.78293934
10skin morphogenesis (GO:0043589)4.61224294
11neuron cell-cell adhesion (GO:0007158)4.53461803
12extracellular matrix assembly (GO:0085029)4.51511363
13cellular response to vitamin D (GO:0071305)4.36787593
14cellular response to vitamin (GO:0071295)4.25509395
15bone trabecula formation (GO:0060346)4.21267886
16cell adhesion mediated by integrin (GO:0033627)4.07902338
17positive regulation of vascular permeability (GO:0043117)3.95490298
18locomotory exploration behavior (GO:0035641)3.94983998
19substrate-dependent cell migration (GO:0006929)3.93090952
20basement membrane organization (GO:0071711)3.87590188
21virion attachment to host cell (GO:0019062)3.86928349
22adhesion of symbiont to host cell (GO:0044650)3.86928349
23Golgi transport vesicle coating (GO:0048200)3.85547002
24COPI coating of Golgi vesicle (GO:0048205)3.85547002
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.83038286
26collagen metabolic process (GO:0032963)3.83021392
27protein retention in ER lumen (GO:0006621)3.82063199
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.76794282
29endothelial cell morphogenesis (GO:0001886)3.75341983
30cell-substrate junction assembly (GO:0007044)3.74521055
31adhesion of symbiont to host (GO:0044406)3.66951260
32collagen catabolic process (GO:0030574)3.65278590
33cell migration involved in heart development (GO:0060973)3.65002550
34lateral sprouting from an epithelium (GO:0060601)3.62088994
35regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.61102451
36negative regulation of chondrocyte differentiation (GO:0032331)3.60204021
37vocalization behavior (GO:0071625)3.56159513
38prepulse inhibition (GO:0060134)3.53415123
39extracellular fibril organization (GO:0043206)3.52879330
40multicellular organismal macromolecule metabolic process (GO:0044259)3.52000133
41extracellular negative regulation of signal transduction (GO:1900116)3.50686453
42extracellular regulation of signal transduction (GO:1900115)3.50686453
43chondroitin sulfate biosynthetic process (GO:0030206)3.50114619
44peptidyl-proline hydroxylation (GO:0019511)3.48475443
45cell migration involved in sprouting angiogenesis (GO:0002042)3.46552794
46extracellular matrix disassembly (GO:0022617)3.45242615
47postsynaptic membrane organization (GO:0001941)3.43935918
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.43618251
49axon extension involved in axon guidance (GO:0048846)3.43618251
50heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.43364630
51negative regulation of smooth muscle cell migration (GO:0014912)3.43178762
52positive regulation of blood vessel endothelial cell migration (GO:0043536)3.30870621
53establishment of nucleus localization (GO:0040023)3.30605439
54multicellular organismal metabolic process (GO:0044236)3.29691196
55multicellular organismal catabolic process (GO:0044243)3.29046851
56positive regulation of synapse assembly (GO:0051965)3.27506670
57endocardial cushion morphogenesis (GO:0003203)3.27312458
58regulation of gonadotropin secretion (GO:0032276)3.24385122
59response to auditory stimulus (GO:0010996)3.22558861
60blood vessel maturation (GO:0001955)3.22023187
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21250040
62protein localization to endosome (GO:0036010)3.17915181
63negative regulation of BMP signaling pathway (GO:0030514)3.16747270
64positive regulation of osteoblast proliferation (GO:0033690)3.16469553
65amino acid import (GO:0043090)3.15158189
66extracellular matrix organization (GO:0030198)3.14689147
67extracellular structure organization (GO:0043062)3.13522523
68substrate adhesion-dependent cell spreading (GO:0034446)3.13335946
69regulation of synapse structural plasticity (GO:0051823)3.12351051
70kidney mesenchyme development (GO:0072074)3.12110934
71protein hydroxylation (GO:0018126)3.10372206
72endocardial cushion development (GO:0003197)3.09341198
73regulation of extracellular matrix disassembly (GO:0010715)3.08569892
74vascular endothelial growth factor signaling pathway (GO:0038084)3.07769484
75glial cell proliferation (GO:0014009)3.05752666
76regulation of integrin-mediated signaling pathway (GO:2001044)3.03565574
77hyaluronan catabolic process (GO:0030214)3.03402209
78negative regulation of focal adhesion assembly (GO:0051895)3.01115933
79negative regulation of cell junction assembly (GO:1901889)3.01115933
80negative regulation of adherens junction organization (GO:1903392)3.01115933
81presynaptic membrane assembly (GO:0097105)3.01043501
82barbed-end actin filament capping (GO:0051016)3.00304827
83negative regulation of astrocyte differentiation (GO:0048712)2.99049988
84cellular response to cholesterol (GO:0071397)2.98857797
85negative regulation of axon extension involved in axon guidance (GO:0048843)2.98764778
86fibril organization (GO:0097435)2.96010403
87dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.95985843
88auditory behavior (GO:0031223)2.95859256
89regulation of early endosome to late endosome transport (GO:2000641)2.95557658
90chondrocyte development (GO:0002063)2.95037976
91exploration behavior (GO:0035640)2.92734004
92regulation of axon extension involved in axon guidance (GO:0048841)2.92245146
93glial cell migration (GO:0008347)2.91587544
94negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.91248524
95regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.90757859
96heparan sulfate proteoglycan metabolic process (GO:0030201)2.90428753
97regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.89860499
98chondrocyte proliferation (GO:0035988)2.89199905
99glomerular basement membrane development (GO:0032836)2.88622571
100alanine transport (GO:0032328)2.87632875
101neurotransmitter-gated ion channel clustering (GO:0072578)2.86906515
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85642151
103positive regulation of fibroblast migration (GO:0010763)2.84173501
104gonadal mesoderm development (GO:0007506)2.84045675
105stress fiber assembly (GO:0043149)2.83873099
106cellular potassium ion homeostasis (GO:0030007)2.82809409
107mesenchymal-epithelial cell signaling (GO:0060638)2.82716765
108regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82598221
109myelination in peripheral nervous system (GO:0022011)2.79128077
110peripheral nervous system axon ensheathment (GO:0032292)2.79128077
111* innervation (GO:0060384)2.79065167
112gamma-aminobutyric acid transport (GO:0015812)2.77172946
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75294417
114negative regulation of fatty acid transport (GO:2000192)2.73794609
115calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.72847015
116positive regulation of smoothened signaling pathway (GO:0045880)2.72709614
117mesenchyme morphogenesis (GO:0072132)2.72560737
118mesodermal cell differentiation (GO:0048333)2.72446265
119vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71378769
120apoptotic cell clearance (GO:0043277)2.70919192
121ovulation cycle (GO:0042698)2.69503397
122regulation of axon guidance (GO:1902667)2.69466577
123hypotonic response (GO:0006971)2.69053162
124chondroitin sulfate metabolic process (GO:0030204)2.68781765
125negative regulation of osteoblast proliferation (GO:0033689)2.68237082
126smooth muscle tissue development (GO:0048745)2.67494055
127lens fiber cell development (GO:0070307)2.67416516
128L-amino acid import (GO:0043092)2.66574009
129cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.66183809
130regulation of synapse assembly (GO:0051963)2.66151705
131regulation of osteoblast proliferation (GO:0033688)2.65634513
132anterior/posterior axis specification, embryo (GO:0008595)2.65235710
133retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64929498
134negative regulation of axon extension (GO:0030517)2.64483083
135cochlea morphogenesis (GO:0090103)2.64200046
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.64102518
137glomerular filtration (GO:0003094)2.63446591
138craniofacial suture morphogenesis (GO:0097094)2.63404701
139layer formation in cerebral cortex (GO:0021819)2.62968896
140* negative regulation of smoothened signaling pathway (GO:0045879)2.59211186
141cell proliferation in forebrain (GO:0021846)2.57466944
142positive regulation of axon extension (GO:0045773)2.56176820
143L-serine transport (GO:0015825)2.55884429
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54463958
145cerebellar granule cell differentiation (GO:0021707)2.51444825
146glomerulus development (GO:0032835)2.50906146
147sodium ion export (GO:0071436)2.49485700
148axonal fasciculation (GO:0007413)2.47563067
149dendrite morphogenesis (GO:0048813)2.47377468
150regulation of glutamate receptor signaling pathway (GO:1900449)2.46972177
151proline transport (GO:0015824)2.46961228
152regulation of synapse organization (GO:0050807)2.44750985
153startle response (GO:0001964)2.44102434
154positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.44022927
155epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.43413073
156* regulation of synaptic transmission, glutamatergic (GO:0051966)2.43301598
157renal filtration (GO:0097205)2.41963179
158oligodendrocyte differentiation (GO:0048709)2.41667664
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41434615
160cell communication by electrical coupling (GO:0010644)2.40952334
161photoreceptor cell differentiation (GO:0046530)2.40236809
162eye photoreceptor cell differentiation (GO:0001754)2.40236809
163neuroblast proliferation (GO:0007405)2.39386335
164positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.39285025
165neuron recognition (GO:0008038)2.39125619
166membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38013281
167presynaptic membrane organization (GO:0097090)2.37091303
168response to gravity (GO:0009629)2.36624389
169glutamate secretion (GO:0014047)2.36263658
170cellular response to sterol (GO:0036315)2.33457967
171outer ear morphogenesis (GO:0042473)2.33030127
172negative regulation of oligodendrocyte differentiation (GO:0048715)2.32581549
173mating behavior (GO:0007617)2.31794786
174synapse assembly (GO:0007416)2.30954003
175atrial cardiac muscle cell action potential (GO:0086014)2.30463054
176dendritic spine morphogenesis (GO:0060997)2.27341404
177regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.26913584
178sensory perception of smell (GO:0007608)2.26503966
179negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.25471362
180somatic stem cell division (GO:0048103)2.24968598
181mechanosensory behavior (GO:0007638)2.24555042
182cGMP-mediated signaling (GO:0019934)2.23690848
183G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.22958216
184regulation of respiratory system process (GO:0044065)2.22017969
185synapse organization (GO:0050808)2.21380390
186metanephric mesenchyme development (GO:0072075)2.19186443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.26425939
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.55809731
3EZH2_22144423_ChIP-Seq_EOC_Human4.05530159
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.08784588
5GBX2_23144817_ChIP-Seq_PC3_Human3.02961221
6RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.99881959
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97806737
8BRD4_25478319_ChIP-Seq_HGPS_Human2.82287677
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80116688
10AR_21572438_ChIP-Seq_LNCaP_Human2.79701858
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.78465928
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77608943
13* EED_16625203_ChIP-ChIP_MESCs_Mouse2.76970560
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74469714
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74469714
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69399847
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.65970417
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65082598
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.54591214
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51193452
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39140451
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33603907
23CLOCK_20551151_ChIP-Seq_293T_Human2.32299855
24* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.29144234
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24590102
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21552726
27* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.20855740
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.18502359
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.14348894
30* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.07984832
31* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06288103
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03919695
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01790394
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.94562582
35* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87021452
36* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.85458615
37* EZH2_27294783_Chip-Seq_ESCs_Mouse1.85215957
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84195607
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.80360223
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76060889
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72311184
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68845648
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68845648
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67870410
45* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66921395
46JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66040467
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65798410
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65244855
49ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.65193388
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64238965
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64058082
52DROSHA_22980978_ChIP-Seq_HELA_Human1.63724409
53* UBF1/2_26484160_Chip-Seq_HMECs_Human1.62641736
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62626551
55TP53_22127205_ChIP-Seq_IMR90_Human1.59842649
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.57553676
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55996135
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.53472084
59ZNF263_19887448_ChIP-Seq_K562_Human1.50990747
60* RING1B_27294783_Chip-Seq_ESCs_Mouse1.50066586
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49007101
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.48027504
63* TP53_20018659_ChIP-ChIP_R1E_Mouse1.47438155
64SMAD4_21799915_ChIP-Seq_A2780_Human1.46318996
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44926862
66TP53_18474530_ChIP-ChIP_U2OS_Human1.43637479
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43342877
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43172307
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41730804
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41723155
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41084414
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38992340
73* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37301221
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37133977
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36356812
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.36093180
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35595255
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35508348
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35442587
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.34734048
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.34544428
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33309992
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31063107
84P300_19829295_ChIP-Seq_ESCs_Human1.30793870
85BCAT_22108803_ChIP-Seq_LS180_Human1.30486079
86* TP53_23651856_ChIP-Seq_MEFs_Mouse1.29143118
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28763920
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.28450921
89SA1_22415368_ChIP-Seq_MEFs_Mouse1.28315073
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27918182
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.27275037
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.24951710
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24856776
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24710171
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24446631
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24287802
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24128771
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24092000
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.19878543
100REST_21632747_ChIP-Seq_MESCs_Mouse1.19610937
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18368134
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17959466
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17366703
104ATF3_27146783_Chip-Seq_COLON_Human1.16373785
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16214094
106AHR_22903824_ChIP-Seq_MCF-7_Human1.15620055
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.15599444
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15503180
109SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14758089
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14636035
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14412572
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13418606
113TP53_16413492_ChIP-PET_HCT116_Human1.12097069
114TBX20_22080862_ChIP-Seq_HEART_Mouse1.11494688
115TBX20_22328084_ChIP-Seq_HEART_Mouse1.11494688
116ZNF274_21170338_ChIP-Seq_K562_Hela1.11124534
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10492024
118AR_19668381_ChIP-Seq_PC3_Human1.08022335
119* STAT3_23295773_ChIP-Seq_U87_Human1.06429998
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06412704
121NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06412704
122AR_25329375_ChIP-Seq_VCAP_Human1.06243816
123RACK7_27058665_Chip-Seq_MCF-7_Human1.06053318
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05630623
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05410613
126TAF15_26573619_Chip-Seq_HEK293_Human1.05307193
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04195526
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04195526
129FUS_26573619_Chip-Seq_HEK293_Human1.03334298
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03184603
131MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02454464
132P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02177291
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01751967
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01121854
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00998081
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00058804
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00054439
138ESR2_21235772_ChIP-Seq_MCF-7_Human1.00000691
139RXR_22108803_ChIP-Seq_LS180_Human0.99743777
140* CJUN_26792858_Chip-Seq_BT549_Human0.99697370
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99343114
142ISL1_27105846_Chip-Seq_CPCs_Mouse0.98799029
143SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98400824
144* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98009105
145KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97851404
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97575133
147LXR_22292898_ChIP-Seq_THP-1_Human0.97315726
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95388792
149ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95089676
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95043945
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94827977
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94774208
153KDM2B_26808549_Chip-Seq_K562_Human0.94586241
154* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93739846
155AR_21909140_ChIP-Seq_LNCAP_Human0.93716632
156TET1_21490601_ChIP-Seq_MESCs_Mouse0.93678630
157* RUNX2_22187159_ChIP-Seq_PCA_Human0.92862321
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92103848
159LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91786059
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91204878
161SMAD3_21741376_ChIP-Seq_HESCs_Human0.89841381
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.89162422
163RARB_27405468_Chip-Seq_BRAIN_Mouse0.88823753
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.88562168
165ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87854760
166TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84858251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.25502469
2MP0008438_abnormal_cutaneous_collagen3.10055244
3MP0003136_yellow_coat_color3.10036748
4MP0005503_abnormal_tendon_morphology2.86103972
5MP0004859_abnormal_synaptic_plasticity2.62365701
6MP0001958_emphysema2.47389670
7MP0005171_absent_coat_pigmentation2.47162009
8MP0005623_abnormal_meninges_morphology2.37874860
9MP0009384_cardiac_valve_regurgitation2.35109790
10MP0002060_abnormal_skin_morphology2.30589615
11MP0006054_spinal_hemorrhage2.29028728
12MP0003279_aneurysm2.28418139
13MP0003566_abnormal_cell_adhesion2.24371896
14MP0009250_abnormal_appendicular_skeleto2.14567406
15MP0001984_abnormal_olfaction2.13407286
16MP0003941_abnormal_skin_development2.06783604
17MP0004272_abnormal_basement_membrane2.06436478
18* MP0003635_abnormal_synaptic_transmissio1.99009280
19MP0010368_abnormal_lymphatic_system1.91081306
20MP0000778_abnormal_nervous_system1.90227823
21MP0005023_abnormal_wound_healing1.89741309
22MP0004885_abnormal_endolymph1.85778973
23MP0001299_abnormal_eye_distance/1.85239910
24MP0000534_abnormal_ureter_morphology1.79767015
25MP0005423_abnormal_somatic_nervous1.78891743
26MP0001486_abnormal_startle_reflex1.78734969
27MP0003880_abnormal_central_pattern1.77870790
28MP0003942_abnormal_urinary_system1.70612061
29MP0010030_abnormal_orbit_morphology1.69573396
30* MP0004858_abnormal_nervous_system1.65230081
31MP0009780_abnormal_chondrocyte_physiolo1.64660968
32MP0002736_abnormal_nociception_after1.64331411
33MP0002063_abnormal_learning/memory/cond1.58342990
34MP0002282_abnormal_trachea_morphology1.56747215
35MP0002877_abnormal_melanocyte_morpholog1.56524565
36MP0005646_abnormal_pituitary_gland1.54579159
37MP0000767_abnormal_smooth_muscle1.52607463
38MP0005508_abnormal_skeleton_morphology1.50804716
39MP0002572_abnormal_emotion/affect_behav1.50072250
40MP0005275_abnormal_skin_tensile1.48499306
41MP0000049_abnormal_middle_ear1.47250472
42MP0001968_abnormal_touch/_nociception1.47027122
43MP0003385_abnormal_body_wall1.46336010
44* MP0003634_abnormal_glial_cell1.45463936
45MP0002108_abnormal_muscle_morphology1.41607236
46MP0002249_abnormal_larynx_morphology1.41493594
47MP0001243_abnormal_dermal_layer1.39842201
48* MP0009745_abnormal_behavioral_response1.38888917
49MP0009053_abnormal_anal_canal1.37616483
50MP0003690_abnormal_glial_cell1.37536220
51* MP0002064_seizures1.35833544
52* MP0002557_abnormal_social/conspecific_i1.35306303
53MP0004134_abnormal_chest_morphology1.32634026
54MP0001502_abnormal_circadian_rhythm1.31867446
55MP0003950_abnormal_plasma_membrane1.31156054
56MP0000428_abnormal_craniofacial_morphol1.29258912
57MP0001849_ear_inflammation1.28556776
58MP0001485_abnormal_pinna_reflex1.26564084
59MP0005408_hypopigmentation1.24206574
60MP0003183_abnormal_peptide_metabolism1.22553731
61MP0001348_abnormal_lacrimal_gland1.19178975
62MP0003115_abnormal_respiratory_system1.18649500
63MP0002295_abnormal_pulmonary_circulatio1.18614734
64MP0009046_muscle_twitch1.18495969
65* MP0002067_abnormal_sensory_capabilities1.18265342
66MP0000631_abnormal_neuroendocrine_gland1.17007608
67MP0004742_abnormal_vestibular_system1.16897628
68MP0003091_abnormal_cell_migration1.15757105
69MP0002233_abnormal_nose_morphology1.15612617
70MP0002089_abnormal_postnatal_growth/wei1.12007260
71MP0002116_abnormal_craniofacial_bone1.11971816
72MP0002184_abnormal_innervation1.09549829
73MP0000026_abnormal_inner_ear1.07822517
74MP0002932_abnormal_joint_morphology1.07340400
75MP0005257_abnormal_intraocular_pressure1.07295012
76MP0002653_abnormal_ependyma_morphology1.06636998
77MP0003283_abnormal_digestive_organ1.06371039
78MP0002734_abnormal_mechanical_nocicepti1.05224518
79MP0010352_gastrointestinal_tract_polyps1.04855160
80MP0003755_abnormal_palate_morphology1.04687825
81MP0004270_analgesia1.04579019
82MP0004233_abnormal_muscle_weight1.04181259
83MP0003329_amyloid_beta_deposits1.02717206
84MP0000163_abnormal_cartilage_morphology1.02301884
85MP0000955_abnormal_spinal_cord1.01707141
86MP0005248_abnormal_Harderian_gland0.99949366
87MP0002272_abnormal_nervous_system0.99339257
88MP0003937_abnormal_limbs/digits/tail_de0.99032603
89MP0000013_abnormal_adipose_tissue0.99025751
90* MP0002152_abnormal_brain_morphology0.98558298
91MP0000579_abnormal_nail_morphology0.96854591
92MP0001177_atelectasis0.96570934
93MP0005390_skeleton_phenotype0.96229270
94MP0005187_abnormal_penis_morphology0.96222100
95MP0002115_abnormal_skeleton_extremities0.96037836
96MP0001542_abnormal_bone_strength0.95520056
97MP0005595_abnormal_vascular_smooth0.95454189
98MP0005377_hearing/vestibular/ear_phenot0.94839652
99MP0003878_abnormal_ear_physiology0.94839652
100MP0001501_abnormal_sleep_pattern0.93912124
101MP0002882_abnormal_neuron_morphology0.93756015
102MP0000467_abnormal_esophagus_morphology0.93541092
103MP0005197_abnormal_uvea_morphology0.92938489
104MP0000751_myopathy0.91966484
105MP0005645_abnormal_hypothalamus_physiol0.91958876
106MP0000733_abnormal_muscle_development0.91170806
107MP0000432_abnormal_head_morphology0.89640251
108MP0000762_abnormal_tongue_morphology0.89592706
109MP0002090_abnormal_vision0.89126470
110MP0001905_abnormal_dopamine_level0.87866402
111MP0001963_abnormal_hearing_physiology0.86871469
112MP0002109_abnormal_limb_morphology0.86557782
113MP0000569_abnormal_digit_pigmentation0.86337539
114MP0000759_abnormal_skeletal_muscle0.85948960
115MP0002733_abnormal_thermal_nociception0.85631460
116MP0001440_abnormal_grooming_behavior0.85412474
117MP0003632_abnormal_nervous_system0.85065501
118MP0002896_abnormal_bone_mineralization0.84459705
119MP0004084_abnormal_cardiac_muscle0.84327124
120MP0000462_abnormal_digestive_system0.83126364
121MP0003938_abnormal_ear_development0.81369167
122MP0001529_abnormal_vocalization0.80480473
123MP0002938_white_spotting0.80028950
124MP0001943_abnormal_respiration0.79727050
125MP0002113_abnormal_skeleton_development0.78288687
126MP0001915_intracranial_hemorrhage0.73653531
127MP0000749_muscle_degeneration0.72729865
128MP0010386_abnormal_urinary_bladder0.72483203
129MP0002114_abnormal_axial_skeleton0.70661985
130MP0005409_darkened_coat_color0.69770930
131MP0005165_increased_susceptibility_to0.67921833
132MP0002133_abnormal_respiratory_system0.67697955
133MP0005388_respiratory_system_phenotype0.67697955
134MP0002128_abnormal_blood_circulation0.66162543
135MP0010771_integument_phenotype0.64941399
136MP0000003_abnormal_adipose_tissue0.64165136
137MP0003795_abnormal_bone_structure0.64084613
138MP0002998_abnormal_bone_remodeling0.64030055
139MP0001614_abnormal_blood_vessel0.63858363
140MP0002168_other_aberrant_phenotype0.63602049
141MP0001879_abnormal_lymphatic_vessel0.63327845
142MP0005058_abnormal_lysosome_morphology0.55833574
143MP0002177_abnormal_outer_ear0.55542598
144MP0003448_altered_tumor_morphology0.55276734
145MP0000604_amyloidosis0.55089042
146MP0009840_abnormal_foam_cell0.54706328
147MP0002925_abnormal_cardiovascular_devel0.54490962
148MP0001175_abnormal_lung_morphology0.52392097
149MP0003045_fibrosis0.52011873
150MP0000538_abnormal_urinary_bladder0.52004961
151MP0005193_abnormal_anterior_eye0.51903030
152MP0002933_joint_inflammation0.50929337

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)4.08105895
2Aplasia of the phalanges of the hand (HP:0009802)4.08105895
3Aplasia involving bones of the extremities (HP:0009825)4.08105895
4Vertebral compression fractures (HP:0002953)3.88004756
5Spinal rigidity (HP:0003306)3.75483008
6Cervical subluxation (HP:0003308)3.69001023
7Protrusio acetabuli (HP:0003179)3.53971387
8Premature rupture of membranes (HP:0001788)3.52169581
9Synostosis involving the elbow (HP:0003938)3.50974591
10Humeroradial synostosis (HP:0003041)3.50974591
11Fragile skin (HP:0001030)3.49194312
12Type 1 muscle fiber predominance (HP:0003803)3.40355326
13Megalencephaly (HP:0001355)3.30008206
14Slender build (HP:0001533)3.23067028
15Neonatal short-limb short stature (HP:0008921)3.13558727
16Coronal craniosynostosis (HP:0004440)3.10858729
17Morphological abnormality of the middle ear (HP:0008609)3.03207373
18Broad metatarsal (HP:0001783)3.01640867
19Hand muscle atrophy (HP:0009130)3.00088823
20Shallow orbits (HP:0000586)2.96976740
21Aortic dissection (HP:0002647)2.93797021
22Vascular tortuosity (HP:0004948)2.93014528
23Arterial tortuosity (HP:0005116)2.92387926
24Distal upper limb amyotrophy (HP:0007149)2.88599144
25Upper limb amyotrophy (HP:0009129)2.88599144
26Fibular aplasia (HP:0002990)2.84821434
27Elbow flexion contracture (HP:0002987)2.82348194
28Abnormality of dentin (HP:0010299)2.81113062
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.79860024
30Bowel diverticulosis (HP:0005222)2.78679735
31Broad ribs (HP:0000885)2.71067430
32Mildly elevated creatine phosphokinase (HP:0008180)2.69453446
33Abnormality of the middle phalanges of the toes (HP:0010183)2.68275744
34Biconcave vertebral bodies (HP:0004586)2.66458130
35Osteolytic defects of the hand bones (HP:0009699)2.64475386
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.64475386
37Oligodactyly (hands) (HP:0001180)2.63607587
38Short hallux (HP:0010109)2.56969836
39Mitral regurgitation (HP:0001653)2.56420450
40Aplasia/Hypoplasia of the fibula (HP:0006492)2.52863048
41Abnormality of the acetabulum (HP:0003170)2.51209252
42Adactyly (HP:0009776)2.50058282
43Increased variability in muscle fiber diameter (HP:0003557)2.44388116
44Abnormality of the 4th metacarpal (HP:0010012)2.42499975
45Tarsal synostosis (HP:0008368)2.40775530
46Joint laxity (HP:0001388)2.40594798
47Aortic aneurysm (HP:0004942)2.38619508
48Aortic regurgitation (HP:0001659)2.38091461
49Increased connective tissue (HP:0009025)2.37791008
50Natal tooth (HP:0000695)2.37597522
51Bell-shaped thorax (HP:0001591)2.33180771
52Synostosis involving bones of the feet (HP:0009140)2.32093091
53Synostosis involving bones of the lower limbs (HP:0009138)2.32093091
54Mild short stature (HP:0003502)2.30068524
55Wrist flexion contracture (HP:0001239)2.29981122
56Short nail (HP:0001799)2.29178552
57Abnormal delivery (HP:0001787)2.28658967
58Mitral stenosis (HP:0001718)2.27771910
59Aplasia/Hypoplasia of the hallux (HP:0008362)2.25610802
60Ankle contracture (HP:0006466)2.24713824
61Narrow nasal bridge (HP:0000446)2.22523508
62Peritonitis (HP:0002586)2.19384468
63Generalized amyotrophy (HP:0003700)2.17558783
64Achilles tendon contracture (HP:0001771)2.16407133
65Joint stiffness (HP:0001387)2.15408703
66Hemiplegia (HP:0002301)2.14689256
67Coxa vara (HP:0002812)2.14333502
68Bronchomalacia (HP:0002780)2.14277158
69Midline defect of the nose (HP:0004122)2.13857880
70Abnormality of carpal bone ossification (HP:0006257)2.13141252
71Limb dystonia (HP:0002451)2.11673585
72Bladder diverticulum (HP:0000015)2.11608662
73Soft skin (HP:0000977)2.10087822
74Upper limb muscle weakness (HP:0003484)2.08699917
75Short 4th metacarpal (HP:0010044)2.08140721
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08140721
77Fibular hypoplasia (HP:0003038)2.07711667
78Ulnar bowing (HP:0003031)2.06452168
79Short middle phalanx of the 5th finger (HP:0004220)2.06289757
80Abnormality of the distal phalanges of the toes (HP:0010182)2.06235385
81Renal duplication (HP:0000075)2.06198200
82Spinal cord compression (HP:0002176)2.05215501
83Limb-girdle muscle weakness (HP:0003325)2.05178178
84Insomnia (HP:0100785)2.02509766
85Neurofibrillary tangles (HP:0002185)2.02402453
86Aortic valve stenosis (HP:0001650)2.01731428
87Mitral valve prolapse (HP:0001634)2.01654043
88Abnormality of skeletal muscle fiber size (HP:0012084)2.01422472
89Aneurysm (HP:0002617)2.01393541
90Absent toe (HP:0010760)2.00061319
91Ovoid vertebral bodies (HP:0003300)1.99969400
92Split foot (HP:0001839)1.99798462
93Genu recurvatum (HP:0002816)1.99427632
94Hemiparesis (HP:0001269)1.98743425
95Cardiovascular calcification (HP:0011915)1.97019276
96Overgrowth (HP:0001548)1.95964459
97Cerebral aneurysm (HP:0004944)1.95738835
98Breech presentation (HP:0001623)1.95210220
99Follicular hyperkeratosis (HP:0007502)1.94941342
100Flared iliac wings (HP:0002869)1.94123183
101Delayed cranial suture closure (HP:0000270)1.93020914
102Flat cornea (HP:0007720)1.89467765
103Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.88856112
104Microglossia (HP:0000171)1.87253515
105Abnormality of the Achilles tendon (HP:0005109)1.87229219
106Abnormal ossification of hand bones (HP:0005921)1.86220378
107Entropion (HP:0000621)1.85349280
108Oligodactyly (HP:0012165)1.85088433
109Hallux valgus (HP:0001822)1.84272503
110Bifid tongue (HP:0010297)1.84029069
111Action tremor (HP:0002345)1.83978510
112Osteoarthritis (HP:0002758)1.82969190
113Small epiphyses (HP:0010585)1.82465184
114Abnormality of the pubic bones (HP:0003172)1.82212988
115Protruding ear (HP:0000411)1.82111816
116Inguinal hernia (HP:0000023)1.80900797
117Hyperextensible skin (HP:0000974)1.80414695
118Aplasia/Hypoplasia of the clavicles (HP:0006710)1.79651440
119Hypoplasia of the iris (HP:0007676)1.79480733
120Mesomelia (HP:0003027)1.78748669
121Disproportionate tall stature (HP:0001519)1.78293963
122Abnormality of the diencephalon (HP:0010662)1.77593983
123Broad long bones (HP:0005622)1.77352813
124Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77221750
125Mixed hearing impairment (HP:0000410)1.77113887
126Symphalangism affecting the phalanges of the hand (HP:0009773)1.75626880
127Infantile muscular hypotonia (HP:0008947)1.75529044
128Wide anterior fontanel (HP:0000260)1.74974678
129White forelock (HP:0002211)1.74427578
130Hyperacusis (HP:0010780)1.74068318
131Delayed closure of the anterior fontanelle (HP:0001476)1.73985609
132Cerebral inclusion bodies (HP:0100314)1.73270780
133Long toe (HP:0010511)1.73010540
134Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.72707357
135Progressive cerebellar ataxia (HP:0002073)1.71918279
136Round ear (HP:0100830)1.71887100
137Hypoventilation (HP:0002791)1.71449176
138Abnormality of the phalanges of the hallux (HP:0010057)1.70950925
139Atrophic scars (HP:0001075)1.70770656
140Camptodactyly of toe (HP:0001836)1.70451810
141Wormian bones (HP:0002645)1.70444575
142J-shaped sella turcica (HP:0002680)1.69987671
143Back pain (HP:0003418)1.69600083
144Venous insufficiency (HP:0005293)1.69360688
145Retinal dysplasia (HP:0007973)1.68985127
146Buphthalmos (HP:0000557)1.68390454
147Abnormality of skull ossification (HP:0002703)1.67643564
148Deviation of the hallux (HP:0010051)1.66658899
149Distal lower limb muscle weakness (HP:0009053)1.66190164
150Anophthalmia (HP:0000528)1.65337618
151Abnormality of the middle phalanges of the hand (HP:0009833)1.64965380
152Morphological abnormality of the inner ear (HP:0011390)1.64123370
153Femoral bowing (HP:0002980)1.62794581
154Dilatation of the ascending aorta (HP:0005111)1.62764561
155Blue sclerae (HP:0000592)1.61283149
156Cutaneous syndactyly (HP:0012725)1.60452139
157Abnormality of the proximal phalanges of the hand (HP:0009834)1.60032855
158Synostosis of carpal bones (HP:0005048)1.59980447
159Myokymia (HP:0002411)1.59973289
160Skull defect (HP:0001362)1.59211515
161Spondylolisthesis (HP:0003302)1.58378372
162Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.58293389
163Epiphyseal dysplasia (HP:0002656)1.55967282
164Hypoplastic nipples (HP:0002557)1.55959502
165Blue irides (HP:0000635)1.55884371
166Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.55673402
167Septo-optic dysplasia (HP:0100842)1.55372786
168Diplopia (HP:0000651)1.55148855
169Abnormality of binocular vision (HP:0011514)1.55148855
170Maternal diabetes (HP:0009800)1.54950292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.74449115
2PDGFRA3.23892708
3NTRK23.02019529
4PAK42.83389228
5DDR22.78686802
6LIMK12.52705657
7PHKG12.51271641
8PHKG22.51271641
9NTRK32.39930962
10TESK12.32245518
11NEK92.30514968
12NTRK11.99547804
13PAK31.98079729
14ARAF1.97708270
15LMTK21.96665259
16ERN11.95729560
17SIK11.93424743
18EPHA41.92786756
19MAPK131.82074761
20NME21.81105864
21PRKD21.79352293
22MAP3K41.77320847
23TRIB31.75043446
24PRKD31.68113594
25ERBB41.67792227
26MAP3K31.65716160
27MARK11.62115293
28FLT31.58255786
29PLK21.54985896
30MET1.51489329
31TYRO31.48488564
32TNIK1.48100016
33FER1.41932696
34AKT31.32977183
35ROCK11.32178261
36PAK61.30941716
37MAP2K71.29530434
38STK381.26601779
39KSR11.25512763
40PNCK1.25298692
41LATS11.23636933
42CAMK1G1.23412775
43PDGFRB1.22027433
44RET1.20602968
45PIM21.18845415
46LATS21.17918566
47PRPF4B1.09434889
48TAOK21.07440386
49ROCK21.05456115
50MUSK1.04912930
51DMPK1.04831244
52ERBB31.03401583
53MAP3K91.03326297
54CSNK1G21.00755973
55CSNK1G10.99501320
56MINK10.97422690
57ICK0.96372986
58EPHA30.93316881
59CDK50.92403169
60ADRBK10.91802720
61MOS0.91716822
62BMX0.91288257
63PAK20.90710560
64ABL20.90566352
65PRKCE0.90016960
66ILK0.86590466
67MYLK0.84625352
68EPHB20.84468659
69PRKCG0.81787416
70STK390.81776106
71SGK20.81426639
72MAPK150.80674369
73CSNK1G30.80193926
74BRAF0.78586648
75EPHA20.76872064
76PTK60.74755965
77NEK60.74651245
78CSNK1A1L0.73729262
79FGFR20.73047890
80PKN20.72834620
81CAMK2A0.72609773
82SCYL20.71995756
83SGK4940.70697110
84SGK2230.70697110
85FGR0.70030120
86IRAK30.69885116
87FGFR10.69745164
88RIPK10.69255217
89MTOR0.66872343
90STK240.66003478
91WNK40.65433572
92TTN0.65337618
93PAK10.65045599
94DYRK1A0.64968379
95PTK2B0.64814131
96CDK140.63655423
97MST1R0.62682090
98CDK150.61847226
99PRKCH0.60712998
100ERBB20.59690803
101MAP3K130.59241142
102IGF1R0.59026854
103RPS6KA20.58927730
104CDK120.58479258
105CDK180.58330127
106MAP3K60.58153169
107MAP2K40.57610454
108FGFR40.57251574
109CAMKK10.56689010
110CAMK1D0.56575712
111GRK50.56262201
112MKNK20.56204205
113IRAK10.55450377
114KSR20.55413138
115PKN10.54395809
116PIK3CA0.54093832
117MAPK70.53706392
118FRK0.52340672
119CDC42BPA0.52211388
120SGK30.52174972
121CDK11A0.50128243
122RAF10.50009396
123SMG10.49299985
124DAPK30.49085252
125PTK20.48284795
126TGFBR20.48088365
127MAP3K20.47179609
128STK30.47042659
129EPHB10.46789821
130WNK10.46192431
131GSK3A0.44911974
132SRC0.44740443
133MAPKAPK50.42937469
134TRPM70.42807663
135PRKCZ0.42366931
136MAP2K10.41383990
137PRKG20.41376660
138MAP3K80.39805826
139PIK3CG0.37595541
140MELK0.37357321
141PRKD10.34420518
142TGFBR10.33814523
143EEF2K0.32532456
144NEK20.32391786
145CAMK2G0.29564972
146BRSK10.28923058
147WEE10.28575574
148PDPK10.27260372

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.10300112
2Olfactory transduction_Homo sapiens_hsa047402.09470265
3Nicotine addiction_Homo sapiens_hsa050331.99946136
4ECM-receptor interaction_Homo sapiens_hsa045121.90795230
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78978438
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72648690
7GABAergic synapse_Homo sapiens_hsa047271.72347628
8Small cell lung cancer_Homo sapiens_hsa052221.69669072
9Glutamatergic synapse_Homo sapiens_hsa047241.67765721
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.66528182
11Cocaine addiction_Homo sapiens_hsa050301.63150394
12Circadian entrainment_Homo sapiens_hsa047131.57490775
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56875289
14Gap junction_Homo sapiens_hsa045401.55177450
15Basal cell carcinoma_Homo sapiens_hsa052171.52648268
16Hedgehog signaling pathway_Homo sapiens_hsa043401.51576471
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51075135
18Gastric acid secretion_Homo sapiens_hsa049711.50894614
19Axon guidance_Homo sapiens_hsa043601.49438294
20Insulin secretion_Homo sapiens_hsa049111.46752661
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.46165564
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46095906
23Salivary secretion_Homo sapiens_hsa049701.44595098
24Melanogenesis_Homo sapiens_hsa049161.42625480
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.40589458
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40143816
27Dilated cardiomyopathy_Homo sapiens_hsa054141.39805602
28Glioma_Homo sapiens_hsa052141.39587883
29Focal adhesion_Homo sapiens_hsa045101.38978934
30Amphetamine addiction_Homo sapiens_hsa050311.38794391
31Renin secretion_Homo sapiens_hsa049241.38562322
32Morphine addiction_Homo sapiens_hsa050321.37660735
33Long-term depression_Homo sapiens_hsa047301.37614715
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35140753
35Dorso-ventral axis formation_Homo sapiens_hsa043201.34844766
36Dopaminergic synapse_Homo sapiens_hsa047281.33451880
37Calcium signaling pathway_Homo sapiens_hsa040201.29089113
38Fatty acid biosynthesis_Homo sapiens_hsa000611.28352798
39N-Glycan biosynthesis_Homo sapiens_hsa005101.23771088
40GnRH signaling pathway_Homo sapiens_hsa049121.22583117
41Cholinergic synapse_Homo sapiens_hsa047251.21908368
42Hippo signaling pathway_Homo sapiens_hsa043901.21563775
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20402549
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19286845
45Estrogen signaling pathway_Homo sapiens_hsa049151.17718696
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15004771
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14855862
48Taste transduction_Homo sapiens_hsa047421.13832940
49Serotonergic synapse_Homo sapiens_hsa047261.12643208
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11002290
51Melanoma_Homo sapiens_hsa052181.10994158
52Synaptic vesicle cycle_Homo sapiens_hsa047211.10615824
53Wnt signaling pathway_Homo sapiens_hsa043101.10070634
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09644073
55Oxytocin signaling pathway_Homo sapiens_hsa049211.08157042
56Long-term potentiation_Homo sapiens_hsa047201.08133589
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07241152
58cAMP signaling pathway_Homo sapiens_hsa040241.06436140
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04501600
60Ovarian steroidogenesis_Homo sapiens_hsa049131.01654191
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98541924
62Proteoglycans in cancer_Homo sapiens_hsa052050.97850043
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97081085
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.96993814
65TGF-beta signaling pathway_Homo sapiens_hsa043500.95921172
66Thyroid hormone synthesis_Homo sapiens_hsa049180.95067264
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94868735
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94243852
69p53 signaling pathway_Homo sapiens_hsa041150.93489642
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92908803
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.91915533
72Thyroid cancer_Homo sapiens_hsa052160.90594785
73Rap1 signaling pathway_Homo sapiens_hsa040150.90084954
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86681778
75MicroRNAs in cancer_Homo sapiens_hsa052060.85436505
76ErbB signaling pathway_Homo sapiens_hsa040120.85399567
77Lysosome_Homo sapiens_hsa041420.85037065
78Protein digestion and absorption_Homo sapiens_hsa049740.84775154
79Galactose metabolism_Homo sapiens_hsa000520.83141461
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82225263
81Adherens junction_Homo sapiens_hsa045200.80648386
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80129401
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79329009
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77648943
85Prion diseases_Homo sapiens_hsa050200.77629648
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74218912
87Endocytosis_Homo sapiens_hsa041440.71794313
88Shigellosis_Homo sapiens_hsa051310.71469206
89Malaria_Homo sapiens_hsa051440.70326571
90Endometrial cancer_Homo sapiens_hsa052130.69995669
91Circadian rhythm_Homo sapiens_hsa047100.69206571
92Amoebiasis_Homo sapiens_hsa051460.68383481
93Choline metabolism in cancer_Homo sapiens_hsa052310.68322386
94Prostate cancer_Homo sapiens_hsa052150.68217135
95Tight junction_Homo sapiens_hsa045300.66237034
96Colorectal cancer_Homo sapiens_hsa052100.65826475
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64685292
98Pathways in cancer_Homo sapiens_hsa052000.63074194
99Ras signaling pathway_Homo sapiens_hsa040140.62160575
100Bladder cancer_Homo sapiens_hsa052190.61971136
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61696928
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60963241
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.60873433
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59514432
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.59417519
106Renal cell carcinoma_Homo sapiens_hsa052110.57527989
107Vitamin B6 metabolism_Homo sapiens_hsa007500.55821890
108Sulfur metabolism_Homo sapiens_hsa009200.53524726
109Pancreatic cancer_Homo sapiens_hsa052120.53077891
110Sphingolipid metabolism_Homo sapiens_hsa006000.52835642
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52051054
112Fatty acid metabolism_Homo sapiens_hsa012120.51614782
113MAPK signaling pathway_Homo sapiens_hsa040100.49688112
114Other glycan degradation_Homo sapiens_hsa005110.49303591
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48335355
116Pentose phosphate pathway_Homo sapiens_hsa000300.47641578
117Vibrio cholerae infection_Homo sapiens_hsa051100.46725551
118Chronic myeloid leukemia_Homo sapiens_hsa052200.46485924
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.46372055
120Glucagon signaling pathway_Homo sapiens_hsa049220.40776479
121Biosynthesis of amino acids_Homo sapiens_hsa012300.39819445
122Phagosome_Homo sapiens_hsa041450.38532795
123VEGF signaling pathway_Homo sapiens_hsa043700.37616943
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36954632
125mTOR signaling pathway_Homo sapiens_hsa041500.36646495
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.35759206
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34871634
128Non-small cell lung cancer_Homo sapiens_hsa052230.34509327
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33914390
130Inositol phosphate metabolism_Homo sapiens_hsa005620.29932909
131TNF signaling pathway_Homo sapiens_hsa046680.29764271
132HIF-1 signaling pathway_Homo sapiens_hsa040660.29617451
133Renin-angiotensin system_Homo sapiens_hsa046140.28756742

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