SERPINE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of lipoprotein metabolic process (GO:0050746)6.44951664
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.26543289
3vitamin A metabolic process (GO:0006776)5.80598454
4high-density lipoprotein particle remodeling (GO:0034375)5.66015836
5polyol transport (GO:0015791)5.34544697
6regulation of triglyceride catabolic process (GO:0010896)5.19832942
7diterpenoid biosynthetic process (GO:0016102)5.07366461
8reverse cholesterol transport (GO:0043691)4.98639138
9phospholipid efflux (GO:0033700)4.96580095
10regulation of hippo signaling (GO:0035330)4.87182544
11cullin deneddylation (GO:0010388)4.71071646
12RNA-dependent DNA replication (GO:0006278)4.65496881
13telomere maintenance via telomerase (GO:0007004)4.46056928
14protein deneddylation (GO:0000338)4.26380392
15sleep (GO:0030431)4.25975322
16righting reflex (GO:0060013)4.17151286
17transepithelial transport (GO:0070633)4.16616423
18neutrophil activation involved in immune response (GO:0002283)4.08581414
19negative regulation of dendrite morphogenesis (GO:0050774)4.07165814
20ER overload response (GO:0006983)4.02658492
21very-low-density lipoprotein particle assembly (GO:0034379)3.98746536
22regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.98437110
23response to misfolded protein (GO:0051788)3.94988141
24negative regulation of lipase activity (GO:0060192)3.89812230
25plasma lipoprotein particle assembly (GO:0034377)3.87958795
26cholesterol efflux (GO:0033344)3.87279294
27negative chemotaxis (GO:0050919)3.77587686
28regulation of activation of Janus kinase activity (GO:0010533)3.73697318
29misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.73635784
30melanin biosynthetic process (GO:0042438)3.73321675
31terpenoid biosynthetic process (GO:0016114)3.73127329
32response to pheromone (GO:0019236)3.70803039
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.58767161
34kinetochore organization (GO:0051383)3.58064912
35secondary metabolite biosynthetic process (GO:0044550)3.57717540
36T-helper 1 type immune response (GO:0042088)3.57012334
37adenosine metabolic process (GO:0046085)3.54074376
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50830280
39positive regulation of osteoblast proliferation (GO:0033690)3.46179001
40retinal metabolic process (GO:0042574)3.44671164
41melanin metabolic process (GO:0006582)3.40531430
42production of molecular mediator involved in inflammatory response (GO:0002532)3.36746351
43negative regulation of neurotransmitter secretion (GO:0046929)3.36556372
44attachment of spindle microtubules to kinetochore (GO:0008608)3.35420499
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34072538
46regulation of DNA endoreduplication (GO:0032875)3.30057217
47kinetochore assembly (GO:0051382)3.26667136
48platelet dense granule organization (GO:0060155)3.25421424
49regulation of fever generation (GO:0031620)3.25198024
50protein-lipid complex assembly (GO:0065005)3.22823604
51eye photoreceptor cell development (GO:0042462)3.22580281
52negative regulation of mast cell activation (GO:0033004)3.22270529
53signal peptide processing (GO:0006465)3.21731486
54photoreceptor cell development (GO:0042461)3.21641096
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20889762
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20889762
57DNA double-strand break processing (GO:0000729)3.17347214
58DNA integration (GO:0015074)3.15940780
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15784973
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.15784973
61modulation by symbiont of host immune response (GO:0052553)3.15784973
62positive regulation by symbiont of host defense response (GO:0052509)3.15784973
63modulation by symbiont of host defense response (GO:0052031)3.15784973
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15784973
65protein-lipid complex remodeling (GO:0034368)3.15505787
66macromolecular complex remodeling (GO:0034367)3.15505787
67plasma lipoprotein particle remodeling (GO:0034369)3.15505787
68cell wall macromolecule catabolic process (GO:0016998)3.14776741
69neutrophil activation (GO:0042119)3.14487790
70positive regulation of action potential (GO:0045760)3.13612455
71negative regulation of sterol transport (GO:0032372)3.12300550
72negative regulation of cholesterol transport (GO:0032375)3.12300550
73positive regulation of response to oxidative stress (GO:1902884)3.10893052
74positive regulation of cellular response to oxidative stress (GO:1900409)3.10893052
75protein K11-linked deubiquitination (GO:0035871)3.10851196
76modulation by symbiont of host cellular process (GO:0044068)3.09708908
77IMP biosynthetic process (GO:0006188)3.08755065
78negative regulation of phagocytosis (GO:0050765)3.04982836
79monoubiquitinated protein deubiquitination (GO:0035520)3.04399867
80triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.04362256
81regulation of penile erection (GO:0060405)3.02234504
82viral entry into host cell (GO:0046718)3.01436971
83regulation of protein glycosylation (GO:0060049)2.98534230
84ketone body metabolic process (GO:1902224)2.97806414
85replicative senescence (GO:0090399)2.97588365
86mitochondrion distribution (GO:0048311)2.96900225
87behavioral response to ethanol (GO:0048149)2.94614593
88positive regulation of protein homodimerization activity (GO:0090073)2.93950275
89retinal cone cell development (GO:0046549)2.93646249
90regulation of apoptotic cell clearance (GO:2000425)2.91903602
91regulation of immunoglobulin secretion (GO:0051023)2.91608971
92granulocyte activation (GO:0036230)2.91396238
93CENP-A containing nucleosome assembly (GO:0034080)2.88421585
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83955263
95negative regulation of translation, ncRNA-mediated (GO:0040033)2.83955263
96regulation of translation, ncRNA-mediated (GO:0045974)2.83955263
97IMP metabolic process (GO:0046040)2.82035428
98positive regulation of heat generation (GO:0031652)2.81230735
99thrombin receptor signaling pathway (GO:0070493)2.81226723
100regulation of NIK/NF-kappaB signaling (GO:1901222)2.80922831
101positive regulation of protein import into nucleus, translocation (GO:0033160)2.77461500
102negative regulation of exocytosis (GO:0045920)2.77376835
103nerve growth factor signaling pathway (GO:0038180)2.76854007
104melanosome organization (GO:0032438)2.76252741
105phagocytosis, recognition (GO:0006910)2.75086504
106urinary tract smooth muscle contraction (GO:0014848)2.74534856
107protein localization to kinetochore (GO:0034501)2.72881987
108regulation of cholesterol esterification (GO:0010872)2.68548511
109positive regulation of vasculogenesis (GO:2001214)2.67131804
110atrial cardiac muscle cell action potential (GO:0086014)2.65633779
111phototransduction, visible light (GO:0007603)2.65307687
112growth hormone secretion (GO:0030252)2.63597563
113DNA damage response, detection of DNA damage (GO:0042769)2.63317319
114ovulation from ovarian follicle (GO:0001542)2.63268372
115pigment granule organization (GO:0048753)2.62779377
116acrosome assembly (GO:0001675)2.61699839
117interkinetic nuclear migration (GO:0022027)2.61584386
118regulation of sarcomere organization (GO:0060297)2.59691951
119glial cell proliferation (GO:0014009)2.59004884
120C4-dicarboxylate transport (GO:0015740)2.58738722
121glucose 6-phosphate metabolic process (GO:0051156)2.58727650
122inositol metabolic process (GO:0006020)2.57551035
123detection of light stimulus involved in visual perception (GO:0050908)2.55776100
124detection of light stimulus involved in sensory perception (GO:0050962)2.55776100
125regulation of digestive system process (GO:0044058)2.55515114
126negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.55419522
127negative regulation of JUN kinase activity (GO:0043508)2.54669677
128peristalsis (GO:0030432)2.54593739
129dendritic cell migration (GO:0036336)2.54191198
130detection of visible light (GO:0009584)2.54046579
131detection of molecule of bacterial origin (GO:0032490)2.52896203
132regulation of centriole replication (GO:0046599)2.52789753
133water-soluble vitamin biosynthetic process (GO:0042364)2.52561936
134regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.52320615
135pyrimidine nucleobase catabolic process (GO:0006208)2.51867037
136quinone biosynthetic process (GO:1901663)2.51655974
137ubiquinone biosynthetic process (GO:0006744)2.51655974
138mitochondrial genome maintenance (GO:0000002)2.51078823
139chromatin remodeling at centromere (GO:0031055)2.51064872
140microtubule anchoring (GO:0034453)2.50167224
141regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.50103094
142sulfation (GO:0051923)2.49603461
143retinol metabolic process (GO:0042572)2.48878159
144positive regulation of growth hormone secretion (GO:0060124)2.48837339
145UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48431656
146gamma-aminobutyric acid signaling pathway (GO:0007214)2.47055318
147short-term memory (GO:0007614)2.46806061
148prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.46349237
149cell wall macromolecule metabolic process (GO:0044036)2.45594378
150ubiquinone metabolic process (GO:0006743)2.43531696
151anterograde synaptic vesicle transport (GO:0048490)2.43243533
152presynaptic membrane assembly (GO:0097105)2.42317353
153positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.41592057
154negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.41575804
155positive regulation of mitochondrial membrane permeability (GO:0035794)2.40701482
156purine nucleobase metabolic process (GO:0006144)2.39970136
157phototransduction (GO:0007602)2.39180001
158megakaryocyte development (GO:0035855)2.38777305
159detection of light stimulus (GO:0009583)2.37852560
160negative regulation of DNA recombination (GO:0045910)2.37180051
161positive regulation of cellular amide metabolic process (GO:0034250)2.36434470
162lipopolysaccharide-mediated signaling pathway (GO:0031663)2.35853113
163histone H3-K9 methylation (GO:0051567)2.35214829
164mitotic metaphase plate congression (GO:0007080)2.34878713
165regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.33508895
166regulation of mitotic spindle checkpoint (GO:1903504)2.33508895
167visual perception (GO:0007601)2.32988315
168positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.32822556
169mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.32822556
170protein-cofactor linkage (GO:0018065)2.32510686
171sensory perception of light stimulus (GO:0050953)2.31370540
172pericardium development (GO:0060039)2.31068025
173behavioral response to nicotine (GO:0035095)2.30848089
174Rap protein signal transduction (GO:0032486)2.30640033
175N-acetylglucosamine metabolic process (GO:0006044)2.29615160
176negative regulation of dendrite development (GO:2000171)2.29409613
177meiotic chromosome segregation (GO:0045132)2.29320846
178response to hyperoxia (GO:0055093)2.29317023
179response to increased oxygen levels (GO:0036296)2.29317023
180retinoid metabolic process (GO:0001523)2.29150361
181heart process (GO:0003015)2.28937999
182heart contraction (GO:0060047)2.28937999
183nucleotide transmembrane transport (GO:1901679)2.28906583
184negative regulation of DNA-dependent DNA replication (GO:2000104)2.28762156
185sister chromatid segregation (GO:0000819)2.28645717
186maturation of 5.8S rRNA (GO:0000460)2.27491299
187regulation of double-strand break repair via homologous recombination (GO:0010569)2.27381137
188ether lipid metabolic process (GO:0046485)2.25358083
189positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.24539424
190response to host immune response (GO:0052572)2.23221701
191response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.23221701
192regulation of heat generation (GO:0031650)2.22910713
193negative regulation of neurotransmitter transport (GO:0051589)2.22333929
194COPI coating of Golgi vesicle (GO:0048205)2.21069236
195Golgi transport vesicle coating (GO:0048200)2.21069236
196establishment of chromosome localization (GO:0051303)2.20963106
197antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.20474973
198viral mRNA export from host cell nucleus (GO:0046784)2.20342757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.61492718
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.35318103
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.85489517
4E2F7_22180533_ChIP-Seq_HELA_Human3.20125697
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99409032
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.94917640
7GATA1_22025678_ChIP-Seq_K562_Human2.91295789
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81755047
9FUS_26573619_Chip-Seq_HEK293_Human2.77584746
10GBX2_23144817_ChIP-Seq_PC3_Human2.73891560
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64490804
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.64387715
13EWS_26573619_Chip-Seq_HEK293_Human2.42805796
14ZNF274_21170338_ChIP-Seq_K562_Hela2.30389623
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26738705
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25268077
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.21732365
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.18394861
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18084583
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08633960
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00059322
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.98804040
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96451514
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.95372298
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93740793
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91146793
27TAF15_26573619_Chip-Seq_HEK293_Human1.89469908
28P300_19829295_ChIP-Seq_ESCs_Human1.88445592
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86672370
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86615769
31VDR_22108803_ChIP-Seq_LS180_Human1.86503802
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85771716
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.85087061
34ELK1_19687146_ChIP-ChIP_HELA_Human1.77157146
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73108463
36STAT3_23295773_ChIP-Seq_U87_Human1.72494910
37* CBP_20019798_ChIP-Seq_JUKART_Human1.71282811
38* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71282811
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71010107
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70446803
41BCAT_22108803_ChIP-Seq_LS180_Human1.67706742
42SMAD4_21799915_ChIP-Seq_A2780_Human1.65414276
43TP53_16413492_ChIP-PET_HCT116_Human1.61833608
44TCF4_23295773_ChIP-Seq_U87_Human1.59388749
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56351403
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55638832
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55638832
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55548750
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54740029
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54279839
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.52233999
52EZH2_22144423_ChIP-Seq_EOC_Human1.50828719
53ER_23166858_ChIP-Seq_MCF-7_Human1.49643478
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49141583
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48715331
56TP53_18474530_ChIP-ChIP_U2OS_Human1.48686837
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47597288
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46222533
59AR_21572438_ChIP-Seq_LNCaP_Human1.45093787
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44991860
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.44286992
62TCF4_22108803_ChIP-Seq_LS180_Human1.43834335
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41830631
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40353301
65AR_21909140_ChIP-Seq_LNCAP_Human1.40105201
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.37276779
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.36615889
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.36342026
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36137173
70AR_25329375_ChIP-Seq_VCAP_Human1.35057271
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34759937
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30795710
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30578995
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30578995
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30398966
76P53_22387025_ChIP-Seq_ESCs_Mouse1.30286574
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.30001822
78CDX2_22108803_ChIP-Seq_LS180_Human1.29677487
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29347088
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29221081
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28187279
82* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26359351
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.26306204
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.25922495
85NMYC_18555785_Chip-Seq_ESCs_Mouse1.25315055
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24845410
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24720150
88P300_18555785_Chip-Seq_ESCs_Mouse1.24564242
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22923310
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21915495
91IGF1R_20145208_ChIP-Seq_DFB_Human1.21815039
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21771533
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.20991078
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20392804
95GABP_17652178_ChIP-ChIP_JURKAT_Human1.20197003
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20138503
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19582056
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19374080
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18663627
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18334697
101IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18316169
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18257442
103TP53_22573176_ChIP-Seq_HFKS_Human1.17429456
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16765074
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16578403
106PU1_27457419_Chip-Seq_LIVER_Mouse1.15173837
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14564676
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14520079
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.12076988
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10953604
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10716985
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.10315300
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10106607
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09388701
115RNF2_27304074_Chip-Seq_NSC_Mouse1.08931844
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08532641
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.07656019
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06272841
119BRD4_25478319_ChIP-Seq_HGPS_Human1.05684548
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05549268
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.04831129
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04712836
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.03748499
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03408665
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03163487
126JUN_21703547_ChIP-Seq_K562_Human1.03057137
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02876721
128TBL1_22424771_ChIP-Seq_293T_Human1.02488026
129IRF8_27001747_Chip-Seq_BMDM_Mouse1.02407708
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02123733
131ZFX_18555785_Chip-Seq_ESCs_Mouse1.01829520
132FOXM1_23109430_ChIP-Seq_U2OS_Human1.01741964
133EP300_21415370_ChIP-Seq_HL-1_Mouse1.01602636
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00437188
135EST1_17652178_ChIP-ChIP_JURKAT_Human1.00269404
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97767831
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97733888
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.97646665
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97396781
140SALL4_22934838_ChIP-ChIP_CD34+_Human0.96702817
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96327567
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96296754
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96117030
144KDM2B_26808549_Chip-Seq_REH_Human0.96054174
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95839822
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95595362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005248_abnormal_Harderian_gland5.37481397
2MP0003011_delayed_dark_adaptation4.90457627
3MP0005646_abnormal_pituitary_gland3.56372793
4MP0009697_abnormal_copulation3.55021145
5MP0005377_hearing/vestibular/ear_phenot3.47307763
6MP0003878_abnormal_ear_physiology3.47307763
7MP0004147_increased_porphyrin_level3.42324009
8MP0009840_abnormal_foam_cell3.35481295
9MP0001188_hyperpigmentation3.33015027
10MP0000569_abnormal_digit_pigmentation3.22539071
11MP0006072_abnormal_retinal_apoptosis2.97215801
12MP0000372_irregular_coat_pigmentation2.90506846
13MP0005253_abnormal_eye_physiology2.85944780
14MP0003123_paternal_imprinting2.84977064
15MP0003880_abnormal_central_pattern2.83654011
16MP0009780_abnormal_chondrocyte_physiolo2.72285808
17MP0001835_abnormal_antigen_presentation2.64072944
18MP0005257_abnormal_intraocular_pressure2.51677454
19MP0002396_abnormal_hematopoietic_system2.49007140
20MP0005408_hypopigmentation2.40970428
21MP0004782_abnormal_surfactant_physiolog2.31462745
22MP0005171_absent_coat_pigmentation2.21695834
23MP0010094_abnormal_chromosome_stability2.15782216
24MP0001986_abnormal_taste_sensitivity2.07722465
25MP0008057_abnormal_DNA_replication2.07055749
26MP0006276_abnormal_autonomic_nervous2.02312758
27MP0002876_abnormal_thyroid_physiology2.01460337
28MP0005551_abnormal_eye_electrophysiolog2.01125864
29MP0004270_analgesia1.93746681
30MP0006292_abnormal_olfactory_placode1.90913919
31MP0002127_abnormal_cardiovascular_syste1.88289958
32MP0001324_abnormal_eye_pigmentation1.87012685
33MP0002419_abnormal_innate_immunity1.84986582
34MP0009785_altered_susceptibility_to1.81830754
35MP0002102_abnormal_ear_morphology1.77271752
36MP0001879_abnormal_lymphatic_vessel1.73367683
37MP0006054_spinal_hemorrhage1.72408530
38MP0002148_abnormal_hypersensitivity_rea1.70588080
39MP0008058_abnormal_DNA_repair1.67654716
40MP0001293_anophthalmia1.66154557
41MP0005360_urolithiasis1.65619782
42MP0003121_genomic_imprinting1.63013656
43MP0001984_abnormal_olfaction1.61396549
44MP0005379_endocrine/exocrine_gland_phen1.61050701
45MP0005423_abnormal_somatic_nervous1.61029886
46MP0005391_vision/eye_phenotype1.59919609
47MP0003136_yellow_coat_color1.54271631
48MP0002332_abnormal_exercise_endurance1.52660658
49MP0001529_abnormal_vocalization1.49725122
50MP0000371_diluted_coat_color1.47760196
51MP0005174_abnormal_tail_pigmentation1.47736359
52MP0005195_abnormal_posterior_eye1.47227505
53MP0002938_white_spotting1.44533534
54MP0000427_abnormal_hair_cycle1.43472392
55MP0004859_abnormal_synaptic_plasticity1.40916524
56MP0005000_abnormal_immune_tolerance1.38235284
57MP0008007_abnormal_cellular_replicative1.36851271
58MP0009046_muscle_twitch1.36837540
59MP0003787_abnormal_imprinting1.36621888
60MP0009745_abnormal_behavioral_response1.35202224
61MP0009764_decreased_sensitivity_to1.31428315
62MP0004084_abnormal_cardiac_muscle1.31025654
63MP0002452_abnormal_antigen_presenting1.30430937
64MP0010030_abnormal_orbit_morphology1.29524394
65MP0000465_gastrointestinal_hemorrhage1.29404853
66MP0008877_abnormal_DNA_methylation1.27442896
67MP0002064_seizures1.26582761
68MP0001348_abnormal_lacrimal_gland1.25023613
69MP0003122_maternal_imprinting1.24188231
70MP0010352_gastrointestinal_tract_polyps1.23969144
71MP0002075_abnormal_coat/hair_pigmentati1.23470193
72MP0003890_abnormal_embryonic-extraembry1.23377330
73MP0003436_decreased_susceptibility_to1.21046618
74MP0003656_abnormal_erythrocyte_physiolo1.20311874
75MP0000778_abnormal_nervous_system1.19961008
76MP0004808_abnormal_hematopoietic_stem1.17637825
77MP0003186_abnormal_redox_activity1.15619561
78MP0000015_abnormal_ear_pigmentation1.14885286
79MP0003111_abnormal_nucleus_morphology1.14366599
80MP0001905_abnormal_dopamine_level1.12173490
81MP0002420_abnormal_adaptive_immunity1.12111099
82MP0001819_abnormal_immune_cell1.09858133
83MP0002163_abnormal_gland_morphology1.09476571
84MP0004233_abnormal_muscle_weight1.09158758
85MP0001800_abnormal_humoral_immune1.08912674
86MP0008789_abnormal_olfactory_epithelium1.08853173
87MP0008775_abnormal_heart_ventricle1.08551945
88MP0002751_abnormal_autonomic_nervous1.08136485
89MP0000631_abnormal_neuroendocrine_gland1.08085869
90MP0005503_abnormal_tendon_morphology1.07996430
91MP0003943_abnormal_hepatobiliary_system1.07486204
92MP0003077_abnormal_cell_cycle1.07268324
93MP0010307_abnormal_tumor_latency1.06690845
94MP0002095_abnormal_skin_pigmentation1.06523826
95MP0002928_abnormal_bile_duct1.06271326
96MP0002723_abnormal_immune_serum1.04150659
97MP0003950_abnormal_plasma_membrane1.03957387
98MP0002734_abnormal_mechanical_nocicepti1.03499673
99MP0004924_abnormal_behavior1.03170755
100MP0005386_behavior/neurological_phenoty1.03170755
101MP0003724_increased_susceptibility_to1.03006387
102MP0004134_abnormal_chest_morphology1.02033953
103MP0005671_abnormal_response_to1.01577764
104MP0003300_gastrointestinal_ulcer1.01129170
105MP0003718_maternal_effect1.00824734
106MP0002006_tumorigenesis1.00804673
107MP0000566_synostosis1.00391465
108MP0003385_abnormal_body_wall1.00105969
109MP0005394_taste/olfaction_phenotype0.97590699
110MP0005499_abnormal_olfactory_system0.97590699
111MP0004142_abnormal_muscle_tone0.97577999
112MP0005387_immune_system_phenotype0.97087388
113MP0001790_abnormal_immune_system0.97087388
114MP0001485_abnormal_pinna_reflex0.96374099
115MP0005197_abnormal_uvea_morphology0.96033760
116MP0002090_abnormal_vision0.95692862
117MP0002736_abnormal_nociception_after0.95652016
118MP0000343_altered_response_to0.95113712
119MP0001968_abnormal_touch/_nociception0.94452693
120MP0000516_abnormal_urinary_system0.94111122
121MP0005367_renal/urinary_system_phenotyp0.94111122
122MP0001764_abnormal_homeostasis0.94062620
123MP0001177_atelectasis0.93408005
124MP0002272_abnormal_nervous_system0.93179450
125MP0002735_abnormal_chemical_nociception0.90806784
126MP0001501_abnormal_sleep_pattern0.90306996
127MP0002184_abnormal_innervation0.90107816
128MP0005220_abnormal_exocrine_pancreas0.89511410
129MP0004510_myositis0.88698576
130MP0002638_abnormal_pupillary_reflex0.88156855
131MP0003566_abnormal_cell_adhesion0.87685929
132MP0004264_abnormal_extraembryonic_tissu0.87153328
133MP0001186_pigmentation_phenotype0.86785502
134MP0005397_hematopoietic_system_phenotyp0.85219401
135MP0001545_abnormal_hematopoietic_system0.85219401
136MP0001440_abnormal_grooming_behavior0.85178127
137MP0004272_abnormal_basement_membrane0.84348819
138MP0002398_abnormal_bone_marrow0.84021671
139MP0001963_abnormal_hearing_physiology0.83913464
140MP0001119_abnormal_female_reproductive0.82783998
141MP0005164_abnormal_response_to0.82783000
142MP0002089_abnormal_postnatal_growth/wei0.81062658
143MP0002752_abnormal_somatic_nervous0.81053231
144MP0005376_homeostasis/metabolism_phenot0.80820126
145MP0001486_abnormal_startle_reflex0.80370933
146MP0002063_abnormal_learning/memory/cond0.80278387
147MP0004215_abnormal_myocardial_fiber0.77807585
148MP0005390_skeleton_phenotype0.77396724
149MP0005409_darkened_coat_color0.76816646
150MP0003635_abnormal_synaptic_transmissio0.76574774
151MP0005025_abnormal_response_to0.76480354
152MP0000716_abnormal_immune_system0.73795419
153MP0002697_abnormal_eye_size0.73176791
154MP0001533_abnormal_skeleton_physiology0.73036464
155MP0003690_abnormal_glial_cell0.72914995
156MP0005084_abnormal_gallbladder_morpholo0.71817832
157MP0002998_abnormal_bone_remodeling0.71425338
158MP0002160_abnormal_reproductive_system0.70877875
159MP0008875_abnormal_xenobiotic_pharmacok0.70689461
160MP0005076_abnormal_cell_differentiation0.70352401
161MP0001286_abnormal_eye_development0.70017226
162MP0001845_abnormal_inflammatory_respons0.70005849
163MP0000639_abnormal_adrenal_gland0.69230581
164MP0005389_reproductive_system_phenotype0.64662054
165MP0002233_abnormal_nose_morphology0.64103033
166MP0003755_abnormal_palate_morphology0.63738477
167MP0002882_abnormal_neuron_morphology0.63692720
168MP0003195_calcinosis0.63415014
169MP0005187_abnormal_penis_morphology0.62338266
170MP0001299_abnormal_eye_distance/0.62332479
171MP0008961_abnormal_basal_metabolism0.62146078
172MP0010386_abnormal_urinary_bladder0.60577497
173MP0002229_neurodegeneration0.60339807

Predicted human phenotypes

RankGene SetZ-score
1Choroideremia (HP:0001139)6.31789611
2Abnormality of the fovea (HP:0000493)5.56461629
3Dyschromatopsia (HP:0007641)4.52368499
4Abnormal rod and cone electroretinograms (HP:0008323)4.42422277
5Hypopigmentation of the fundus (HP:0007894)4.25768556
6Submucous cleft hard palate (HP:0000176)4.24249951
7Irregular epiphyses (HP:0010582)4.10991047
8Macular degeneration (HP:0000608)3.94870847
9Hypobetalipoproteinemia (HP:0003563)3.76942279
10Small epiphyses (HP:0010585)3.61259773
11Asymmetry of the thorax (HP:0001555)3.54728094
12Hyperventilation (HP:0002883)3.44257674
13Abnormality of the nasal septum (HP:0000419)3.38637255
14Abnormality of the astrocytes (HP:0100707)3.38331022
15Astrocytoma (HP:0009592)3.38331022
16Bony spicule pigmentary retinopathy (HP:0007737)3.34902090
17Pancreatic islet-cell hyperplasia (HP:0004510)3.25871341
18Abnormal hair whorl (HP:0010721)3.25485845
19Fair hair (HP:0002286)3.25165415
20Papillary thyroid carcinoma (HP:0002895)3.24603529
21Neoplasm of the adrenal cortex (HP:0100641)3.21246114
22Flat capital femoral epiphysis (HP:0003370)3.17387347
23Pigmentary retinal degeneration (HP:0001146)3.16282646
24Cellulitis (HP:0100658)3.11322080
25Scotoma (HP:0000575)3.03794137
26Cutaneous melanoma (HP:0012056)3.01723088
27Chronic hepatic failure (HP:0100626)2.99685128
28Hepatoblastoma (HP:0002884)2.99332328
29Epiphyseal dysplasia (HP:0002656)2.97875599
30Pendular nystagmus (HP:0012043)2.95047114
31Abnormal foot bone ossification (HP:0010675)2.89226655
32Spinal cord lesions (HP:0100561)2.87724626
33Syringomyelia (HP:0003396)2.87724626
34Cerebellar dysplasia (HP:0007033)2.83600704
35Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.81271771
36Absent epiphyses (HP:0010577)2.81271771
37Scanning speech (HP:0002168)2.78598736
38Microglossia (HP:0000171)2.75756330
39Prostate neoplasm (HP:0100787)2.74153747
40Genital tract atresia (HP:0001827)2.73343680
41Generalized hypopigmentation of hair (HP:0011358)2.72473281
42Type 2 muscle fiber atrophy (HP:0003554)2.71332665
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.71194182
44Tubulointerstitial nephritis (HP:0001970)2.70199445
45Abnormality of macular pigmentation (HP:0008002)2.69781739
46Abolished electroretinogram (ERG) (HP:0000550)2.69722483
47Congenital primary aphakia (HP:0007707)2.69214893
48Abnormality of placental membranes (HP:0011409)2.68694312
49Amniotic constriction ring (HP:0009775)2.68694312
50Medial flaring of the eyebrow (HP:0010747)2.68539456
51Gait imbalance (HP:0002141)2.68237876
52Bilateral sensorineural hearing impairment (HP:0008619)2.66110087
53Pancreatic fibrosis (HP:0100732)2.65650560
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.65311108
55Severe Myopia (HP:0011003)2.62263586
56Pancreatic cysts (HP:0001737)2.60528315
57Optic nerve hypoplasia (HP:0000609)2.59488161
58Hypoplasia of the fovea (HP:0007750)2.57991316
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.57991316
60Fetal akinesia sequence (HP:0001989)2.57749078
61Ependymoma (HP:0002888)2.56844163
62Glioma (HP:0009733)2.55982921
63Progressive cerebellar ataxia (HP:0002073)2.55939682
64Calf muscle hypertrophy (HP:0008981)2.54662713
65Autoamputation (HP:0001218)2.53038863
66Popliteal pterygium (HP:0009756)2.49160658
67Protruding tongue (HP:0010808)2.47692763
68Hypokinesia (HP:0002375)2.45622392
69Abnormality of incisor morphology (HP:0011063)2.44558380
70Rough bone trabeculation (HP:0100670)2.43440994
71Short chin (HP:0000331)2.42369829
72Vaginal atresia (HP:0000148)2.42133062
73Type II lissencephaly (HP:0007260)2.41653047
74Nephrogenic diabetes insipidus (HP:0009806)2.41548334
75Abnormal tarsal ossification (HP:0008369)2.39680478
76Poor coordination (HP:0002370)2.37185043
77Irregular vertebral endplates (HP:0003301)2.36734245
78Thyroid carcinoma (HP:0002890)2.36426109
79Barrel-shaped chest (HP:0001552)2.34650271
80Embryonal renal neoplasm (HP:0011794)2.31482764
81Febrile seizures (HP:0002373)2.28219881
82Relative macrocephaly (HP:0004482)2.27697804
83Nephroblastoma (Wilms tumor) (HP:0002667)2.27652919
84Mesomelia (HP:0003027)2.27439382
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.25615580
86Molar tooth sign on MRI (HP:0002419)2.25612891
87Abnormality of midbrain morphology (HP:0002418)2.25612891
88Hyperlipoproteinemia (HP:0010980)2.24063538
89Renal Fanconi syndrome (HP:0001994)2.24002370
90Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23041354
91Retinal dysplasia (HP:0007973)2.21359850
92Muscle fiber atrophy (HP:0100295)2.20001231
93Genetic anticipation (HP:0003743)2.18052136
94Colon cancer (HP:0003003)2.16194384
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15417636
96Chromsome breakage (HP:0040012)2.14589053
97Atonic seizures (HP:0010819)2.14561995
98Bone marrow hypocellularity (HP:0005528)2.13591983
99Aplasia/Hypoplasia involving the musculature (HP:0001460)2.13263518
100Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.11404664
101Neoplasm of the adrenal gland (HP:0100631)2.11028087
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10537764
103Birth length less than 3rd percentile (HP:0003561)2.10411789
104Shoulder girdle muscle weakness (HP:0003547)2.09970231
105Abnormality of the vertebral endplates (HP:0005106)2.09829634
106Abnormality of the labia minora (HP:0012880)2.09653018
107Blue irides (HP:0000635)2.09259344
108Vitreoretinal degeneration (HP:0000655)2.09005398
109Lissencephaly (HP:0001339)2.08492762
110Abnormality of endocrine pancreas physiology (HP:0012093)2.07858304
111Abnormality of the pancreatic islet cells (HP:0006476)2.07858304
112Clubbing of toes (HP:0100760)2.07608317
113Muscle hypertrophy of the lower extremities (HP:0008968)2.07333497
114Bifid tongue (HP:0010297)2.07083747
115Recurrent lower respiratory tract infections (HP:0002783)2.06222403
116Hypochromic anemia (HP:0001931)2.05684569
117Deep philtrum (HP:0002002)2.05512987
118Recurrent abscess formation (HP:0002722)2.04304466
119Keratoconjunctivitis sicca (HP:0001097)2.04234805
120Supernumerary spleens (HP:0009799)2.04171121
121Epileptic encephalopathy (HP:0200134)2.04131224
122Proximal amyotrophy (HP:0007126)2.03774805
123Thyroiditis (HP:0100646)2.03661362
124Attenuation of retinal blood vessels (HP:0007843)2.02720076
125Abnormality of the femoral head (HP:0003368)2.02149974
126Recurrent pneumonia (HP:0006532)2.01832994
127Drooling (HP:0002307)2.01496569
128Melanoma (HP:0002861)2.01222504
129Abnormal trabecular bone morphology (HP:0100671)2.00474296
130Neutropenia (HP:0001875)1.99702039
131Focal motor seizures (HP:0011153)1.99231754
132Horizontal nystagmus (HP:0000666)1.99006765
133Increased IgM level (HP:0003496)1.98960803
134Premature graying of hair (HP:0002216)1.98711796
135Chorioretinal atrophy (HP:0000533)1.98307515
136Encephalitis (HP:0002383)1.98113657
137Abnormality of the prostate (HP:0008775)1.97883012
138Freckling (HP:0001480)1.96851965
139Pelvic girdle muscle weakness (HP:0003749)1.96026052
140Abnormal biliary tract physiology (HP:0012439)1.94736264
141Bile duct proliferation (HP:0001408)1.94736264
142Stomatitis (HP:0010280)1.94717436
143Aplasia/Hypoplasia of the macula (HP:0008059)1.93518543
144Abnormality of the hip-girdle musculature (HP:0001445)1.91613101
145Abnormality of the musculature of the pelvis (HP:0001469)1.91613101
146Abnormality of the metopic suture (HP:0005556)1.91254956
147Stillbirth (HP:0003826)1.91002444
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90428438
149Severe visual impairment (HP:0001141)1.90300312
150Abnormality of the epiphysis of the femoral head (HP:0010574)1.90125354
151Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.89812951
152Abnormality of femoral epiphyses (HP:0006499)1.89812951
153Clumsiness (HP:0002312)1.89327878
154Hyperglycinemia (HP:0002154)1.88469787
155Abnormality of the preputium (HP:0100587)1.88295341
156Abnormality of binocular vision (HP:0011514)1.87237626
157Diplopia (HP:0000651)1.87237626
158Onycholysis (HP:0001806)1.86451070
159Abnormality of T cell physiology (HP:0011840)1.86102444
160Occipital encephalocele (HP:0002085)1.85853588
161Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84911814
162Meckel diverticulum (HP:0002245)1.84846290
163True hermaphroditism (HP:0010459)1.83913398
164Metaphyseal cupping (HP:0003021)1.83196661
165Heterotopia (HP:0002282)1.83018309
166Adrenal hypoplasia (HP:0000835)1.82669866
167Gaze-evoked nystagmus (HP:0000640)1.82610745
168Glycosuria (HP:0003076)1.82526080
169Abnormality of urine glucose concentration (HP:0011016)1.82526080
170Abnormality of T cell number (HP:0011839)1.82169793
171Microcytic anemia (HP:0001935)1.82153931
17211 pairs of ribs (HP:0000878)1.81990444
173Distal lower limb muscle weakness (HP:0009053)1.81906036
174Short tibia (HP:0005736)1.81594870
175Nephronophthisis (HP:0000090)1.81237365
176Absent frontal sinuses (HP:0002688)1.80629267
177Acute necrotizing encephalopathy (HP:0006965)1.80437050
178Generalized hypopigmentation (HP:0007513)1.78762100
179Abnormality of the ileum (HP:0001549)1.78621037
180Cystic hygroma (HP:0000476)1.78161335
181Facial hemangioma (HP:0000329)1.78016615
182Absent speech (HP:0001344)1.77619384
183Albinism (HP:0001022)1.77355546
184Lower limb asymmetry (HP:0100559)1.77097467
185Fibular hypoplasia (HP:0003038)1.76733877
186Abnormality of the anterior horn cell (HP:0006802)1.76692300
187Degeneration of anterior horn cells (HP:0002398)1.76692300
188Abnormality of the neuromuscular junction (HP:0003398)1.76428900
189Fatigable weakness (HP:0003473)1.76428900
190Abnormality of T cells (HP:0002843)1.76150788
191Alveolar cell carcinoma (HP:0006519)1.76126942
192Flattened epiphyses (HP:0003071)1.75972938
193Keratoconjunctivitis (HP:0001096)1.75832977
194Abnormality of chromosome stability (HP:0003220)1.74360006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.47781233
2CDK124.61276765
3MST43.34658595
4AKT33.15525028
5CASK2.78193044
6PLK22.69985911
7WNK32.50285543
8NUAK12.49516295
9TNK22.41398900
10EIF2AK32.37895961
11MAP3K142.30339212
12NME12.26135788
13EIF2AK12.25476641
14FGFR22.22312881
15PBK2.11262254
16IRAK32.09992031
17CLK12.05229398
18PLK31.90504368
19MKNK11.90430170
20TNIK1.87490845
21BRD41.87486901
22MAP3K41.82747631
23BMPR21.81009285
24BCR1.73612980
25MARK31.70995020
26SGK21.67823352
27TESK21.67098317
28BCKDK1.66540937
29TXK1.61563022
30TSSK61.60948719
31MET1.56559576
32STK38L1.56281658
33EIF2AK21.53977870
34SIK31.43548936
35MKNK21.40538208
36MYLK1.38785274
37DDR21.35462202
38BRSK21.34058210
39ERBB31.31813503
40CSNK1A1L1.25673045
41PLK41.22526130
42ZAK1.20101447
43OBSCN1.19208978
44MAP3K121.18293728
45SGK31.17608485
46DAPK11.12758503
47MST1R1.12022254
48CSNK1G21.11452681
49MAP2K71.10774154
50EPHA41.10407699
51NEK61.06050951
52ERBB41.04672847
53YES11.03908299
54CDK191.03372541
55FRK1.02651527
56MAP2K31.01716257
57CDC70.98888863
58NTRK30.98841746
59SRPK10.98067785
60CSNK1G10.98048186
61INSRR0.97252623
62STK100.91285695
63STK390.89240488
64IRAK40.88980794
65PASK0.87219541
66ADRBK10.86632206
67MAPK70.85612691
68PRKCE0.84887331
69MARK10.84005827
70CCNB10.82397929
71RAF10.81661952
72SGK4940.81170545
73SGK2230.81170545
74CSNK1G30.80542450
75DYRK1A0.78713933
76OXSR10.77840744
77TGFBR10.77365360
78STK380.76759693
79PRKG20.76622239
80LATS10.73709521
81PIM10.73067345
82BMPR1B0.72824830
83PIK3CA0.70897919
84KSR10.69984701
85MINK10.68707814
86CDK80.67122083
87NEK90.66570236
88STK40.66026554
89PIK3CG0.64718121
90TEC0.64584088
91RPS6KC10.64152555
92RPS6KL10.64152555
93FER0.63864129
94BMX0.63342202
95PKN10.62892403
96TIE10.61568596
97DYRK20.60619320
98RIPK40.60527404
99LIMK10.57684096
100MAP3K30.57149926
101RPS6KA60.55423291
102CAMK1G0.53764851
103TAOK30.53293214
104PAK60.53087011
105MUSK0.52991637
106GRK70.52766320
107BRAF0.52637240
108CAMK2A0.51145341
109PRKAA20.48540826
110FGFR30.48262890
111PRKCZ0.48124146
112PLK10.47000880
113BTK0.46807681
114PRKACB0.45511162
115CDK90.44109458
116ADRBK20.43468110
117HIPK20.42498116
118PRKCD0.42399958
119NLK0.41380202
120MAPKAPK20.41233212
121GRK50.40835554
122LYN0.40638485
123PRKCG0.40008959
124CDK50.38969986
125MAPK130.37956996
126ACVR1B0.37417920
127GRK10.36957105
128ATM0.36470595
129MAP3K60.35943684
130PDK20.35841016
131PAK30.35734858
132DYRK30.35618565
133CAMK2B0.35461609
134PRKG10.35447742
135PRKAA10.34996286
136CAMK2G0.34416351
137STK30.34163037
138VRK10.33887546
139ATR0.33756187
140RPS6KB10.32952020
141CAMK1D0.32267797
142PINK10.31547098
143ROCK10.29640492
144WNK40.28942236
145MAP2K40.27368116
146MELK0.26655956
147FLT30.25128990
148CSNK1D0.24356689
149BUB10.24026474
150TAF10.18952593
151MAP3K50.18894064

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.92648047
2Type I diabetes mellitus_Homo sapiens_hsa049402.89529240
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.79752052
4Protein export_Homo sapiens_hsa030602.54818565
5Graft-versus-host disease_Homo sapiens_hsa053322.52598621
6Proteasome_Homo sapiens_hsa030502.46781986
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.38404736
8Rheumatoid arthritis_Homo sapiens_hsa053232.27686251
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26698799
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.21691826
11Allograft rejection_Homo sapiens_hsa053302.05002738
12Circadian rhythm_Homo sapiens_hsa047102.02125858
13RNA degradation_Homo sapiens_hsa030181.92190967
14Steroid biosynthesis_Homo sapiens_hsa001001.90073540
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88293444
16Fanconi anemia pathway_Homo sapiens_hsa034601.84938331
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84128185
18Linoleic acid metabolism_Homo sapiens_hsa005911.75824140
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75320100
20Non-homologous end-joining_Homo sapiens_hsa034501.74888763
21Mismatch repair_Homo sapiens_hsa034301.72907092
22Autoimmune thyroid disease_Homo sapiens_hsa053201.70843729
23Nicotine addiction_Homo sapiens_hsa050331.69270470
24Fat digestion and absorption_Homo sapiens_hsa049751.67461967
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67159472
26Chemical carcinogenesis_Homo sapiens_hsa052041.66099984
27beta-Alanine metabolism_Homo sapiens_hsa004101.63438534
28Propanoate metabolism_Homo sapiens_hsa006401.61486661
29Ether lipid metabolism_Homo sapiens_hsa005651.61090565
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55743838
31RNA transport_Homo sapiens_hsa030131.55591069
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54989497
33Mineral absorption_Homo sapiens_hsa049781.53540318
34Histidine metabolism_Homo sapiens_hsa003401.51097549
35Phagosome_Homo sapiens_hsa041451.50964127
36Cell cycle_Homo sapiens_hsa041101.50456563
37Legionellosis_Homo sapiens_hsa051341.48842836
38Nucleotide excision repair_Homo sapiens_hsa034201.48129058
39Tyrosine metabolism_Homo sapiens_hsa003501.48086291
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46707542
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.46356703
42One carbon pool by folate_Homo sapiens_hsa006701.44661993
43Vibrio cholerae infection_Homo sapiens_hsa051101.43514981
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42098121
45Lysine degradation_Homo sapiens_hsa003101.41477094
46Selenocompound metabolism_Homo sapiens_hsa004501.41407739
47Taste transduction_Homo sapiens_hsa047421.41232057
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38430324
49Measles_Homo sapiens_hsa051621.38015833
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.35685783
51DNA replication_Homo sapiens_hsa030301.32843736
52Basal transcription factors_Homo sapiens_hsa030221.29717691
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25499529
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25333542
55African trypanosomiasis_Homo sapiens_hsa051431.23216158
56Malaria_Homo sapiens_hsa051441.18104444
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18013355
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.17396092
59Collecting duct acid secretion_Homo sapiens_hsa049661.15740737
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15530340
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15052191
62Antigen processing and presentation_Homo sapiens_hsa046121.14618334
63Sulfur metabolism_Homo sapiens_hsa009201.14185509
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13880369
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12441038
66Phototransduction_Homo sapiens_hsa047441.12096545
67Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11953975
68Herpes simplex infection_Homo sapiens_hsa051681.09048426
69Leishmaniasis_Homo sapiens_hsa051401.09038344
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08640010
71Retinol metabolism_Homo sapiens_hsa008301.07578836
72Regulation of autophagy_Homo sapiens_hsa041401.06629112
73Homologous recombination_Homo sapiens_hsa034401.06357058
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04390631
75Olfactory transduction_Homo sapiens_hsa047401.03812697
76NF-kappa B signaling pathway_Homo sapiens_hsa040641.03156796
77SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02770832
78Sphingolipid metabolism_Homo sapiens_hsa006001.01796608
79Hedgehog signaling pathway_Homo sapiens_hsa043401.00128351
80Phenylalanine metabolism_Homo sapiens_hsa003600.98893044
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98537724
82Butanoate metabolism_Homo sapiens_hsa006500.98377441
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96997543
84Long-term potentiation_Homo sapiens_hsa047200.96752448
85Pyrimidine metabolism_Homo sapiens_hsa002400.95199448
86Glutamatergic synapse_Homo sapiens_hsa047240.94331662
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94136114
88Base excision repair_Homo sapiens_hsa034100.91793329
89Inositol phosphate metabolism_Homo sapiens_hsa005620.91442334
90ABC transporters_Homo sapiens_hsa020100.90394824
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89061249
92Oxidative phosphorylation_Homo sapiens_hsa001900.88751861
93Serotonergic synapse_Homo sapiens_hsa047260.88074686
94Hippo signaling pathway_Homo sapiens_hsa043900.86073500
95Morphine addiction_Homo sapiens_hsa050320.82915730
96Influenza A_Homo sapiens_hsa051640.81933210
97Ovarian steroidogenesis_Homo sapiens_hsa049130.81568286
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81457171
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80088079
100Apoptosis_Homo sapiens_hsa042100.79295500
101GABAergic synapse_Homo sapiens_hsa047270.77371231
102Melanoma_Homo sapiens_hsa052180.77194148
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76580012
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76473434
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76098164
106Adherens junction_Homo sapiens_hsa045200.74718539
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.73143337
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72838576
109Circadian entrainment_Homo sapiens_hsa047130.72668983
110Purine metabolism_Homo sapiens_hsa002300.71527495
111Staphylococcus aureus infection_Homo sapiens_hsa051500.69579125
112Complement and coagulation cascades_Homo sapiens_hsa046100.69026792
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.68994623
114Glycerolipid metabolism_Homo sapiens_hsa005610.68213131
115Epstein-Barr virus infection_Homo sapiens_hsa051690.68031523
116Hematopoietic cell lineage_Homo sapiens_hsa046400.67479042
117Renin-angiotensin system_Homo sapiens_hsa046140.66538981
118Parkinsons disease_Homo sapiens_hsa050120.66249951
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66222954
120Metabolic pathways_Homo sapiens_hsa011000.66185619
121Tryptophan metabolism_Homo sapiens_hsa003800.65744268
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65569549
123Tight junction_Homo sapiens_hsa045300.65307882
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63967357
125Primary immunodeficiency_Homo sapiens_hsa053400.63540037
126Asthma_Homo sapiens_hsa053100.63408501
127Vitamin B6 metabolism_Homo sapiens_hsa007500.62072752
128Basal cell carcinoma_Homo sapiens_hsa052170.61151225
129Huntingtons disease_Homo sapiens_hsa050160.60988075
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60458913
131Oocyte meiosis_Homo sapiens_hsa041140.60388216
132Bile secretion_Homo sapiens_hsa049760.58339687
133Axon guidance_Homo sapiens_hsa043600.57962443
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57577167
135Dopaminergic synapse_Homo sapiens_hsa047280.57238773
136Tuberculosis_Homo sapiens_hsa051520.57008334
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56969639
138Wnt signaling pathway_Homo sapiens_hsa043100.55660257
139Dorso-ventral axis formation_Homo sapiens_hsa043200.55255731
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54224522
141cAMP signaling pathway_Homo sapiens_hsa040240.53392954
142mRNA surveillance pathway_Homo sapiens_hsa030150.53102094
143Galactose metabolism_Homo sapiens_hsa000520.52656740
144Amphetamine addiction_Homo sapiens_hsa050310.51708585
145Glutathione metabolism_Homo sapiens_hsa004800.51680669
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50053881
147Pertussis_Homo sapiens_hsa051330.49749360
148RNA polymerase_Homo sapiens_hsa030200.49691489
149Alzheimers disease_Homo sapiens_hsa050100.49586508
150Salmonella infection_Homo sapiens_hsa051320.49513303
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49505545
152Platelet activation_Homo sapiens_hsa046110.47564321
153Synaptic vesicle cycle_Homo sapiens_hsa047210.47382108
154TNF signaling pathway_Homo sapiens_hsa046680.46276227
155Dilated cardiomyopathy_Homo sapiens_hsa054140.45873168
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45086157
157Hepatitis C_Homo sapiens_hsa051600.44793012
158p53 signaling pathway_Homo sapiens_hsa041150.43862695
159Fatty acid degradation_Homo sapiens_hsa000710.42658630
160Arachidonic acid metabolism_Homo sapiens_hsa005900.42413529
161FoxO signaling pathway_Homo sapiens_hsa040680.42394115
162Cysteine and methionine metabolism_Homo sapiens_hsa002700.41816242
163Fructose and mannose metabolism_Homo sapiens_hsa000510.41351419
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40044794
165Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37959353
166TGF-beta signaling pathway_Homo sapiens_hsa043500.37394731
167Calcium signaling pathway_Homo sapiens_hsa040200.36397360
168HIF-1 signaling pathway_Homo sapiens_hsa040660.36103089

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