SERPINF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.59330775
2L-phenylalanine catabolic process (GO:0006559)7.59330775
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27861729
4L-phenylalanine metabolic process (GO:0006558)7.27861729
5aromatic amino acid family catabolic process (GO:0009074)6.78104812
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.43448363
7tryptophan catabolic process (GO:0006569)6.09416982
8indole-containing compound catabolic process (GO:0042436)6.09416982
9indolalkylamine catabolic process (GO:0046218)6.09416982
10glyoxylate metabolic process (GO:0046487)6.04886148
11kynurenine metabolic process (GO:0070189)5.96167362
12intestinal cholesterol absorption (GO:0030299)5.89674766
13bile acid biosynthetic process (GO:0006699)5.84849467
14epoxygenase P450 pathway (GO:0019373)5.75990973
15tryptophan metabolic process (GO:0006568)5.75060012
16high-density lipoprotein particle remodeling (GO:0034375)5.71276088
17urea metabolic process (GO:0019627)5.62966859
18urea cycle (GO:0000050)5.62966859
19exogenous drug catabolic process (GO:0042738)5.57699320
20cysteine metabolic process (GO:0006534)5.51960702
21alpha-linolenic acid metabolic process (GO:0036109)5.44179991
22regulation of apoptotic cell clearance (GO:2000425)5.42254028
23sulfur amino acid catabolic process (GO:0000098)5.39792847
24protein carboxylation (GO:0018214)5.39471198
25peptidyl-glutamic acid carboxylation (GO:0017187)5.39471198
26regulation of protein activation cascade (GO:2000257)5.35185469
27* negative regulation of fibrinolysis (GO:0051918)5.31300243
28complement activation, alternative pathway (GO:0006957)5.26247159
29serine family amino acid catabolic process (GO:0009071)5.22413880
30* regulation of fibrinolysis (GO:0051917)5.22120118
31nitrogen cycle metabolic process (GO:0071941)5.17838529
32omega-hydroxylase P450 pathway (GO:0097267)5.17357606
33reverse cholesterol transport (GO:0043691)5.08658395
34negative regulation of protein activation cascade (GO:2000258)5.04131003
35bile acid metabolic process (GO:0008206)4.98205809
36regulation of cholesterol esterification (GO:0010872)4.96478120
37regulation of complement activation (GO:0030449)4.96444129
38aromatic amino acid family metabolic process (GO:0009072)4.93634430
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.93406900
40plasma lipoprotein particle remodeling (GO:0034369)4.91789336
41protein-lipid complex remodeling (GO:0034368)4.91789336
42macromolecular complex remodeling (GO:0034367)4.91789336
43protein-lipid complex subunit organization (GO:0071825)4.91372525
44regulation of triglyceride catabolic process (GO:0010896)4.86158012
45homocysteine metabolic process (GO:0050667)4.79966658
46tyrosine metabolic process (GO:0006570)4.77893756
47regulation of humoral immune response (GO:0002920)4.75684008
48lysine metabolic process (GO:0006553)4.74742626
49lysine catabolic process (GO:0006554)4.74742626
50phospholipid efflux (GO:0033700)4.69245629
51acylglycerol homeostasis (GO:0055090)4.67963971
52triglyceride homeostasis (GO:0070328)4.67963971
53alpha-amino acid catabolic process (GO:1901606)4.66248739
54amino-acid betaine metabolic process (GO:0006577)4.65577906
55positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.61320537
56negative regulation of sterol transport (GO:0032372)4.57849893
57negative regulation of cholesterol transport (GO:0032375)4.57849893
58plasma lipoprotein particle clearance (GO:0034381)4.55240550
59cellular ketone body metabolic process (GO:0046950)4.54764329
60* acute-phase response (GO:0006953)4.48743165
61glycine metabolic process (GO:0006544)4.45479505
62* negative regulation of hemostasis (GO:1900047)4.45193837
63* negative regulation of blood coagulation (GO:0030195)4.45193837
64* regulation of plasminogen activation (GO:0010755)4.34381164
65cholesterol efflux (GO:0033344)4.33315404
66ethanol metabolic process (GO:0006067)4.32625301
67indolalkylamine metabolic process (GO:0006586)4.32278621
68glutamate metabolic process (GO:0006536)4.32031091
69cellular amino acid catabolic process (GO:0009063)4.30955458
70positive regulation of fatty acid biosynthetic process (GO:0045723)4.30530760
71serine family amino acid metabolic process (GO:0009069)4.30190431
72imidazole-containing compound metabolic process (GO:0052803)4.28958596
73coenzyme catabolic process (GO:0009109)4.26803675
74bile acid and bile salt transport (GO:0015721)4.26576844
75cellular biogenic amine catabolic process (GO:0042402)4.21994765
76amine catabolic process (GO:0009310)4.21994765
77cellular modified amino acid catabolic process (GO:0042219)4.18597748
78serine family amino acid biosynthetic process (GO:0009070)4.17721773
79plasma lipoprotein particle assembly (GO:0034377)4.17267202
80cellular glucuronidation (GO:0052695)4.11637518
81benzene-containing compound metabolic process (GO:0042537)4.09963563
82dicarboxylic acid biosynthetic process (GO:0043650)4.09289231
83aldehyde catabolic process (GO:0046185)4.07776138
84* negative regulation of coagulation (GO:0050819)4.06013999
85arginine metabolic process (GO:0006525)4.04983507
86drug catabolic process (GO:0042737)4.04761865
87negative regulation of complement activation (GO:0045916)4.03466988
88proline metabolic process (GO:0006560)4.03000592
89low-density lipoprotein particle remodeling (GO:0034374)4.02232347
90ethanol oxidation (GO:0006069)3.99377419
91lipoprotein metabolic process (GO:0042157)3.98322645
92blood coagulation, intrinsic pathway (GO:0007597)3.97242427
93ketone body metabolic process (GO:1902224)3.93622554
94* negative regulation of wound healing (GO:0061045)3.92767648
95positive regulation of triglyceride lipase activity (GO:0061365)3.91410390
96positive regulation of lipoprotein lipase activity (GO:0051006)3.91410390
97cytolysis (GO:0019835)3.90989595
98* positive regulation of hemostasis (GO:1900048)3.90686140
99* positive regulation of blood coagulation (GO:0030194)3.90686140
100drug metabolic process (GO:0017144)3.83125023
101phospholipid homeostasis (GO:0055091)3.82739703
102cholesterol homeostasis (GO:0042632)3.80643493
103cholesterol transport (GO:0030301)3.77313735
104sterol transport (GO:0015918)3.77313735
105cofactor catabolic process (GO:0051187)3.76945173
106very-low-density lipoprotein particle assembly (GO:0034379)3.76703394
107plasma lipoprotein particle organization (GO:0071827)3.76208794
108organic acid catabolic process (GO:0016054)3.76060553
109carboxylic acid catabolic process (GO:0046395)3.76060553
110sterol homeostasis (GO:0055092)3.74894771
111positive regulation of lipid catabolic process (GO:0050996)3.74723055
112* fibrinolysis (GO:0042730)3.74266868
113intestinal absorption (GO:0050892)3.74212746
114protein-lipid complex assembly (GO:0065005)3.74204731
115short-chain fatty acid metabolic process (GO:0046459)3.72598465
116negative regulation of lipase activity (GO:0060192)3.72220941
117protein activation cascade (GO:0072376)3.71414334
118complement activation, classical pathway (GO:0006958)3.69191556
119uronic acid metabolic process (GO:0006063)3.67385723
120glucuronate metabolic process (GO:0019585)3.67385723
121regulation of cholesterol homeostasis (GO:2000188)3.66660718
122regulation of bile acid biosynthetic process (GO:0070857)3.66373401
123complement activation (GO:0006956)3.65685396
124acetyl-CoA metabolic process (GO:0006084)3.64137752
125urate metabolic process (GO:0046415)3.63229005
126regulation of cholesterol biosynthetic process (GO:0045540)3.59286796
127drug transmembrane transport (GO:0006855)3.57406778
128heme transport (GO:0015886)3.56550472
129* positive regulation of coagulation (GO:0050820)3.54898278
130killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.51503707
131disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.51503707
132opsonization (GO:0008228)3.45208556
133positive regulation of extracellular matrix organization (GO:1903055)3.43966549
134positive regulation of steroid metabolic process (GO:0045940)3.36860090
135peptidyl-glutamic acid modification (GO:0018200)3.36810287
136negative regulation of lipid transport (GO:0032369)3.34893987
137regulation of lipoprotein particle clearance (GO:0010984)3.34224520
138diacylglycerol metabolic process (GO:0046339)3.34010435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.38858631
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20936282
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.92866150
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.47936613
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23913651
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.13176280
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89557280
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03294317
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01728932
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08490706
11* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04674491
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0968788
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.99235841
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98991121
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62129332
16CLOCK_20551151_ChIP-Seq_293T_Human1.57258156
17GATA1_22025678_ChIP-Seq_K562_Human1.52787151
18HTT_18923047_ChIP-ChIP_STHdh_Human1.47916527
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.43499020
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34949477
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.33429017
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20618715
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18007076
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13479006
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11434840
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.09901401
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09804536
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07034657
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.05306108
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03825588
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00271515
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93868509
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93733637
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91833456
35HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89685165
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89213597
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89176894
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87991151
39POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86608383
40IRF8_22096565_ChIP-ChIP_GC-B_Human0.86156716
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85129357
42DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83408333
43AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82768730
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82676959
45GATA4_25053715_ChIP-Seq_YYC3_Human0.82667135
46NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81703528
47SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79973091
48ZNF263_19887448_ChIP-Seq_K562_Human0.78489309
49SMC4_20622854_ChIP-Seq_HELA_Human0.76575309
50RARA_24833708_ChIP-Seq_LIVER_Mouse0.75199256
51AR_21909140_ChIP-Seq_LNCAP_Human0.74224297
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74207963
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73255833
54* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72371035
55RAC3_21632823_ChIP-Seq_H3396_Human0.71595023
56* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71508855
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69325672
58ESR2_21235772_ChIP-Seq_MCF-7_Human0.68010737
59SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67660407
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67367757
61SOX2_20726797_ChIP-Seq_SW620_Human0.67125411
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66750106
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66355707
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66068521
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65652725
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65633536
67NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.64904187
68RARB_24833708_ChIP-Seq_LIVER_Mouse0.63743892
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62802254
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62404122
71RACK7_27058665_Chip-Seq_MCF-7_Human0.62366304
72SOX2_21211035_ChIP-Seq_LN229_Human0.62309312
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.62173163
74* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61146267
75CSB_26484114_Chip-Seq_FIBROBLAST_Human0.60757275
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.60560671
77LXR_22292898_ChIP-Seq_THP-1_Human0.60286730
78STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58798306
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58695990
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58695990
81SOX11_22085726_ChIP-Seq_ESNs_Mouse0.58683521
82P68_20966046_ChIP-Seq_HELA_Human0.58520297
83CEBPB_22108803_ChIP-Seq_LS180_Human0.58029498
84EGR1_19032775_ChIP-ChIP_M12_Human0.57132948
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.56112413
86JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.55290355
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.54316050
88GATA1_19941826_ChIP-Seq_K562_Human0.53835708
89CTNNB1_20460455_ChIP-Seq_HCT116_Human0.53762585
90MYC_19915707_ChIP-ChIP_AK7_Human0.53734137
91E2F1_20622854_ChIP-Seq_HELA_Human0.53458025
92AR_20517297_ChIP-Seq_VCAP_Human0.53245246
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.53156767
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.52791805
95FOXA1_25552417_ChIP-Seq_VCAP_Human0.52401432
96ESR1_21235772_ChIP-Seq_MCF-7_Human0.52216950
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.51975853
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.51677394
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.51589905
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.51568565
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51259458
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50943645
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49959165
104SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.49689986
105SPI1_20517297_ChIP-Seq_HL60_Human0.47603395
106CBP_21632823_ChIP-Seq_H3396_Human0.47249767
107ESET_19884257_ChIP-Seq_ESCs_Mouse0.46860192
108P53_21459846_ChIP-Seq_SAOS-2_Human0.46579863
109GATA2_19941826_ChIP-Seq_K562_Human0.46054131
110TAF2_19829295_ChIP-Seq_ESCs_Human0.45576092
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.45138444
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44840121
113STAT1_17558387_ChIP-Seq_HELA_Human0.44668601
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44264339
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43495200
116GATA6_25053715_ChIP-Seq_YYC3_Human0.43033284
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.42694701
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42587257
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41693731
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40622415
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.39843207
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39482884
123MYC_27129775_Chip-Seq_CORNEA_Mouse0.37822342
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.35642660
125SPI1_26923725_Chip-Seq_HPCs_Mouse0.35360014
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.35040740
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.34911811
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.34715394
129OCT4_20526341_ChIP-Seq_ESCs_Human0.34641731
130FOXH1_21741376_ChIP-Seq_EPCs_Human0.34598386
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.34495083
132ERG_20517297_ChIP-Seq_VCAP_Human0.34488522
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33763782
134SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33584717
135* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.33469645
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.33429795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21624853
2MP0005360_urolithiasis7.65962296
3MP0005085_abnormal_gallbladder_physiolo6.32652166
4MP0005365_abnormal_bile_salt6.09151285
5MP0008875_abnormal_xenobiotic_pharmacok4.98332230
6MP0003806_abnormal_nucleotide_metabolis4.20182745
7MP0003252_abnormal_bile_duct3.86499799
8MP0010329_abnormal_lipoprotein_level3.59921587
9MP0009840_abnormal_foam_cell3.30643119
10MP0005083_abnormal_biliary_tract3.08946109
11MP0003195_calcinosis2.90490078
12MP0005332_abnormal_amino_acid2.88359584
13MP0003122_maternal_imprinting2.72778688
14MP0001666_abnormal_nutrient_absorption2.57318892
15MP0003191_abnormal_cellular_cholesterol2.49866372
16MP0004019_abnormal_vitamin_homeostasis2.29107456
17MP0000609_abnormal_liver_physiology2.16276980
18MP0002118_abnormal_lipid_homeostasis2.08831451
19MP0002138_abnormal_hepatobiliary_system2.08775560
20MP0000566_synostosis1.96405678
21MP0003868_abnormal_feces_composition1.83711470
22MP0005319_abnormal_enzyme/_coenzyme1.83523216
23MP0001764_abnormal_homeostasis1.69558613
24MP0005584_abnormal_enzyme/coenzyme_acti1.59973022
25MP0009697_abnormal_copulation1.55399726
26MP0001915_intracranial_hemorrhage1.54364204
27MP0002132_abnormal_respiratory_system1.54252214
28MP0002089_abnormal_postnatal_growth/wei1.54070694
29MP0003011_delayed_dark_adaptation1.46113851
30MP0003172_abnormal_lysosome_physiology1.44099801
31MP0003656_abnormal_erythrocyte_physiolo1.43922695
32MP0005451_abnormal_body_composition1.42795976
33MP0009643_abnormal_urine_homeostasis1.36579967
34MP0003186_abnormal_redox_activity1.31701050
35MP0003123_paternal_imprinting1.28997815
36MP0000598_abnormal_liver_morphology1.19714672
37MP0003705_abnormal_hypodermis_morpholog1.15473073
38MP0000604_amyloidosis1.12971967
39MP0005647_abnormal_sex_gland1.08630189
40MP0005636_abnormal_mineral_homeostasis1.08130245
41MP0009764_decreased_sensitivity_to1.04936187
42MP0002254_reproductive_system_inflammat1.02697962
43MP0009763_increased_sensitivity_to1.01549695
44MP0010368_abnormal_lymphatic_system0.99723808
45MP0008469_abnormal_protein_level0.90644809
46* MP0009642_abnormal_blood_homeostasis0.88579239
47MP0005084_abnormal_gallbladder_morpholo0.88504270
48MP0005408_hypopigmentation0.87065000
49MP0005409_darkened_coat_color0.86364994
50MP0006036_abnormal_mitochondrial_physio0.86105284
51MP0003879_abnormal_hair_cell0.82297278
52MP0005376_homeostasis/metabolism_phenot0.80759046
53MP0002078_abnormal_glucose_homeostasis0.78256869
54MP0009780_abnormal_chondrocyte_physiolo0.78005327
55MP0009765_abnormal_xenobiotic_induced0.77578501
56MP0002876_abnormal_thyroid_physiology0.76781183
57MP0004272_abnormal_basement_membrane0.76205354
58MP0005220_abnormal_exocrine_pancreas0.75624202
59MP0005670_abnormal_white_adipose0.73924346
60MP0002971_abnormal_brown_adipose0.70129360
61MP0001756_abnormal_urination0.69821855
62MP0002282_abnormal_trachea_morphology0.69115413
63MP0005167_abnormal_blood-brain_barrier0.69101894
64MP0001661_extended_life_span0.68585345
65MP0009053_abnormal_anal_canal0.67371225
66MP0005535_abnormal_body_temperature0.67360702
67MP0005334_abnormal_fat_pad0.66145428
68MP0003329_amyloid_beta_deposits0.64891184
69MP0003690_abnormal_glial_cell0.64866847
70MP0004130_abnormal_muscle_cell0.63812603
71MP0005257_abnormal_intraocular_pressure0.63355174
72MP0005266_abnormal_metabolism0.62836366
73MP0000639_abnormal_adrenal_gland0.59894261
74MP0005464_abnormal_platelet_physiology0.58663020
75MP0006035_abnormal_mitochondrial_morpho0.56317068
76MP0002136_abnormal_kidney_physiology0.55610191
77MP0002249_abnormal_larynx_morphology0.55488388
78MP0005448_abnormal_energy_balance0.53318360
79MP0005377_hearing/vestibular/ear_phenot0.51915575
80MP0003878_abnormal_ear_physiology0.51915575
81MP0005395_other_phenotype0.51130775
82MP0003121_genomic_imprinting0.50481269
83MP0005023_abnormal_wound_healing0.49719765
84MP0002928_abnormal_bile_duct0.49637821
85MP0003567_abnormal_fetal_cardiomyocyte0.47698834
86MP0004264_abnormal_extraembryonic_tissu0.47435579
87MP0003183_abnormal_peptide_metabolism0.47107928
88MP0003638_abnormal_response/metabolism_0.46924023
89MP0006054_spinal_hemorrhage0.46567265
90MP0002909_abnormal_adrenal_gland0.45888879
91MP0003718_maternal_effect0.45801902
92MP0003115_abnormal_respiratory_system0.45231002
93MP0002822_catalepsy0.44652063
94MP0008873_increased_physiological_sensi0.43377419
95MP0003724_increased_susceptibility_to0.42367260
96MP0008874_decreased_physiological_sensi0.42033302
97MP0003566_abnormal_cell_adhesion0.41775554
98MP0003075_altered_response_to0.41715637
99MP0000858_altered_metastatic_potential0.41400571
100MP0003953_abnormal_hormone_level0.41348525
101MP0005076_abnormal_cell_differentiation0.41132939
102MP0003436_decreased_susceptibility_to0.41067765
103MP0003632_abnormal_nervous_system0.40904493
104MP0009672_abnormal_birth_weight0.39251501
105MP0002837_dystrophic_cardiac_calcinosis0.39212711
106MP0004782_abnormal_surfactant_physiolog0.39169913
107MP0000920_abnormal_myelination0.38915397
108MP0002933_joint_inflammation0.38378115
109MP0005666_abnormal_adipose_tissue0.38361303
110MP0005166_decreased_susceptibility_to0.37936657
111MP0008872_abnormal_physiological_respon0.37427120
112MP0003943_abnormal_hepatobiliary_system0.35457809
113MP0004883_abnormal_blood_vessel0.34793891
114MP0002796_impaired_skin_barrier0.34624160
115MP0002092_abnormal_eye_morphology0.34281384
116MP0000003_abnormal_adipose_tissue0.34019079
117MP0002168_other_aberrant_phenotype0.33037907
118MP0005248_abnormal_Harderian_gland0.32867430
119MP0000230_abnormal_systemic_arterial0.32849942
120MP0000249_abnormal_blood_vessel0.32069557
121MP0004043_abnormal_pH_regulation0.32051472
122MP0005058_abnormal_lysosome_morphology0.31906901
123MP0009115_abnormal_fat_cell0.31750686
124MP0003950_abnormal_plasma_membrane0.31655046
125MP0001324_abnormal_eye_pigmentation0.31007091
126MP0006292_abnormal_olfactory_placode0.30610064
127MP0004381_abnormal_hair_follicle0.30256554
128MP0001243_abnormal_dermal_layer0.30047788
129MP0006082_CNS_inflammation0.29770789
130MP0000579_abnormal_nail_morphology0.29464955
131MP0001845_abnormal_inflammatory_respons0.29428747
132MP0002970_abnormal_white_adipose0.29157403
133MP0009384_cardiac_valve_regurgitation0.28981489
134MP0004147_increased_porphyrin_level0.28341028
135MP0001765_abnormal_ion_homeostasis0.28051618
136MP0005164_abnormal_response_to0.27115714
137MP0002135_abnormal_kidney_morphology0.26642467

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.38865060
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31327159
3Intrahepatic cholestasis (HP:0001406)7.14412780
4Prolonged partial thromboplastin time (HP:0003645)6.51728282
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.47573522
6Xanthomatosis (HP:0000991)6.27175398
7Hypobetalipoproteinemia (HP:0003563)6.22601813
8Hyperlipoproteinemia (HP:0010980)5.40153185
9Complement deficiency (HP:0004431)5.25133905
10Hypolipoproteinemia (HP:0010981)4.77417829
11Hyperammonemia (HP:0001987)4.62038835
12Abnormality of the common coagulation pathway (HP:0010990)4.54461358
13Hyperglycinemia (HP:0002154)4.43310171
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34451160
15Ketosis (HP:0001946)4.31635248
16Epidermoid cyst (HP:0200040)4.31021889
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.28576388
18Hypoalphalipoproteinemia (HP:0003233)4.24664224
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.22507301
20Abnormality of methionine metabolism (HP:0010901)4.16489848
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13146331
22* Joint hemorrhage (HP:0005261)4.12730283
23Hyperglycinuria (HP:0003108)4.06089258
24Abnormality of glycine metabolism (HP:0010895)4.02618257
25Abnormality of serine family amino acid metabolism (HP:0010894)4.02618257
26Fat malabsorption (HP:0002630)4.01431375
27Hypoglycemic coma (HP:0001325)3.89212686
28Abnormality of complement system (HP:0005339)3.82768426
29Abnormality of pyrimidine metabolism (HP:0004353)3.77758639
30Abnormality of the intrinsic pathway (HP:0010989)3.75728892
31Conjugated hyperbilirubinemia (HP:0002908)3.58870391
32Hypercholesterolemia (HP:0003124)3.52574904
33Hyperbilirubinemia (HP:0002904)3.40186263
34Abnormality of fatty-acid metabolism (HP:0004359)3.35966478
35Nephritis (HP:0000123)3.29820163
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27468492
37Purpura (HP:0000979)3.27256809
38Spontaneous abortion (HP:0005268)3.19354275
39Abnormality of nucleobase metabolism (HP:0010932)3.14120378
40Delayed CNS myelination (HP:0002188)3.12099270
41Hypochromic microcytic anemia (HP:0004840)3.09470958
42Ketoacidosis (HP:0001993)3.09043834
43Hepatocellular carcinoma (HP:0001402)3.08044416
44Abnormality of serum amino acid levels (HP:0003112)3.06484503
45Steatorrhea (HP:0002570)2.96306424
46Myocardial infarction (HP:0001658)2.85687795
47Metabolic acidosis (HP:0001942)2.83336784
48Abnormality of purine metabolism (HP:0004352)2.82301247
49Gout (HP:0001997)2.77183449
50Acanthocytosis (HP:0001927)2.72477741
51Systemic lupus erythematosus (HP:0002725)2.71464356
52Vascular calcification (HP:0004934)2.65655799
53Skin nodule (HP:0200036)2.65048957
54Dicarboxylic aciduria (HP:0003215)2.63359194
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63359194
56Lethargy (HP:0001254)2.62949219
57Abnormal gallbladder morphology (HP:0012437)2.49414931
58Hypoglycemic seizures (HP:0002173)2.48379284
59Glomerulonephritis (HP:0000099)2.46766487
60Cholelithiasis (HP:0001081)2.44952857
61Osteomalacia (HP:0002749)2.44872569
62Spastic diplegia (HP:0001264)2.43731416
63Cerebral edema (HP:0002181)2.43124619
64Amyloidosis (HP:0011034)2.41480178
65Abnormality of carpal bone ossification (HP:0006257)2.41159389
66Irritability (HP:0000737)2.37818683
67Neonatal onset (HP:0003623)2.36888620
68Abnormal gallbladder physiology (HP:0012438)2.36394899
69Cholecystitis (HP:0001082)2.36394899
70Mitral stenosis (HP:0001718)2.35823940
71Cardiovascular calcification (HP:0011915)2.35347182
72Gingival bleeding (HP:0000225)2.30510136
73Recurrent gram-negative bacterial infections (HP:0005420)2.30458975
74Malnutrition (HP:0004395)2.29847084
75Arthropathy (HP:0003040)2.28084028
76Abnormal tarsal ossification (HP:0008369)2.26121072
77Generalized aminoaciduria (HP:0002909)2.23635376
78Enlarged kidneys (HP:0000105)2.22450611
79Esophageal varix (HP:0002040)2.20639040
80Thrombophlebitis (HP:0004418)2.20406005
81Poikilocytosis (HP:0004447)2.20283724
82Pulmonary embolism (HP:0002204)2.19293498
83Menorrhagia (HP:0000132)2.18632634
84Pancreatitis (HP:0001733)2.17957585
85Sensorimotor neuropathy (HP:0007141)2.16479158
86Vomiting (HP:0002013)2.14740157
87Late onset (HP:0003584)2.14725640
88Abnormality of the Achilles tendon (HP:0005109)2.09083185
89Brushfield spots (HP:0001088)2.06185811
90Broad alveolar ridges (HP:0000187)2.06157368
91Increased serum pyruvate (HP:0003542)2.05862892
92Rickets (HP:0002748)2.04781009
93Abnormality of the gallbladder (HP:0005264)2.03993829
94Hyperinsulinemic hypoglycemia (HP:0000825)2.01724226
95Hemorrhage of the eye (HP:0011885)2.01490912
96Potter facies (HP:0002009)2.00511281
97Facial shape deformation (HP:0011334)2.00511281
98Opisthotonus (HP:0002179)1.99929998
99Alkalosis (HP:0001948)1.99008486
100Hydroxyprolinuria (HP:0003080)1.96636400
101Abnormality of proline metabolism (HP:0010907)1.96636400
102Bifid scrotum (HP:0000048)1.95856602
103Abnormality of iron homeostasis (HP:0011031)1.93874691
104Proximal tubulopathy (HP:0000114)1.93687710
105Abnormality of transition element cation homeostasis (HP:0011030)1.93454817
106Hypophosphatemic rickets (HP:0004912)1.91360410
107Abnormal enzyme/coenzyme activity (HP:0012379)1.89627746
108Flat acetabular roof (HP:0003180)1.89172985
109Hyperuricemia (HP:0002149)1.87239381
110Increased purine levels (HP:0004368)1.87239381
111Epistaxis (HP:0000421)1.86827803
112Pancreatic islet-cell hyperplasia (HP:0004510)1.86333349
113Abnormal cartilage morphology (HP:0002763)1.86090313
114Abnormality of glycolysis (HP:0004366)1.84489750
115Asymmetry of the thorax (HP:0001555)1.84218025
116Vaginal fistula (HP:0004320)1.83723143
117Elevated hepatic transaminases (HP:0002910)1.80543790
118Renal cortical cysts (HP:0000803)1.80198989
119Abnormality of the lumbar spine (HP:0100712)1.80045083
120Glycosuria (HP:0003076)1.79906114
121Small epiphyses (HP:0010585)1.78999287
122Abnormal delivery (HP:0001787)1.78385524
123Joint swelling (HP:0001386)1.75295620
124Abnormal ossification of hand bones (HP:0005921)1.74825891
125Abnormal hand bone ossification (HP:0010660)1.74636432
126Gangrene (HP:0100758)1.64557925
127Hepatoblastoma (HP:0002884)1.63250846
128Widely patent fontanelles and sutures (HP:0004492)1.61364350
129Increased serum ferritin (HP:0003281)1.57927835
130Fair hair (HP:0002286)1.55011287
131Abnormality of the nasal septum (HP:0000419)1.53892544
132Broad palm (HP:0001169)1.53189485
133Reduced antithrombin III activity (HP:0001976)1.49784443
134Urinary glycosaminoglycan excretion (HP:0003541)1.49004969
135Mucopolysacchariduria (HP:0008155)1.49004969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.38963024
2FGFR44.73263589
3ERN14.39584068
4SIK14.36489317
5TAOK32.98140579
6INSRR2.95229443
7CDK122.83329277
8ERBB42.81042716
9TYRO32.27042468
10MAP2K42.24841089
11MST1R2.21712695
12PKN22.12802053
13MAPK111.99893542
14PIK3CA1.99533184
15PDGFRA1.92133447
16TRIB31.87138901
17FGFR11.85398656
18FLT31.82064648
19PIK3CG1.79342671
20TYK21.76910341
21LATS11.58482359
22DAPK21.56101928
23PTK61.53015584
24ABL21.49980833
25AKT31.41251729
26NEK91.40521589
27KDR1.33709377
28WNK11.31640121
29EEF2K1.30279875
30SIK21.27719854
31JAK21.23869892
32GRK61.22582764
33FGFR21.21268518
34FRK1.21047048
35DDR21.15427938
36MAP3K71.15304515
37PINK11.12767562
38PRKAA21.11352069
39MAP2K31.10456840
40MAP3K21.07639417
41SMG11.07057241
42STK38L1.03905249
43ERBB21.03674477
44MAP3K101.03319106
45EIF2AK11.00260823
46TBK10.99882557
47NTRK30.96017085
48JAK10.95702325
49EPHB10.95216528
50MET0.93398952
51MAPK40.92817996
52MAP3K30.90831548
53MAP3K110.90492752
54PRKCZ0.90286262
55MAP3K140.86296120
56MAPK150.85803135
57CDK70.84290711
58CDK60.81563153
59TIE10.81234710
60EPHA20.80959003
61DYRK1B0.80517482
62MAPK120.79096743
63FGR0.78292072
64PRKACG0.77853488
65EPHA30.74690499
66GSK3A0.72851364
67MAPKAPK30.69262015
68CDC42BPA0.68626973
69PRKAA10.66881423
70SGK10.66861882
71CSK0.66252240
72CAMK2G0.65750075
73SGK30.65673176
74PTK20.64187387
75TGFBR20.63598919
76CSNK1E0.63238739
77MAP2K60.60924688
78RPS6KB10.60378019
79RIPK10.60002720
80KSR20.58292614
81CAMK1D0.58150526
82PDPK10.53730751
83IRAK30.52454056
84MAPK70.50387212
85FGFR30.50166746
86CSF1R0.49827309
87IKBKE0.49466111
88TAOK20.49185228
89SGK20.47903270
90PRKCQ0.47707732
91MATK0.47043331
92SGK2230.45863933
93SGK4940.45863933
94CDK40.45730298
95BRSK10.43780270
96MAP2K10.43399309
97GRK10.43331809
98CSNK1G10.43074648
99MAP3K50.41848997
100SRC0.41802349
101CSNK1D0.41599996
102PBK0.40439164
103PRKCG0.40174990
104EPHA40.39945489
105IGF1R0.39391477
106MTOR0.37025863
107RET0.36384713
108BRD40.35680990
109ICK0.35355190
110WNK40.34726543
111WNK30.34310071
112PRKG10.34203978
113PKN10.33454922
114MAP3K60.33394137
115EGFR0.32653473
116PDK10.32638992
117RPS6KA30.32586721
118CSNK2A20.32342473
119MAP3K130.32244015
120NEK20.31977932
121MARK20.31405830
122BCR0.30797651
123MAP3K10.30762117
124CAMK40.29173731
125CSNK2A10.28993478
126MAPK30.27154584
127NLK0.26726869
128CDK80.26275614
129PDK30.26266361
130PDK40.26266361
131PRKCA0.25738852
132BRSK20.25537903
133MAP2K20.24065793
134PDGFRB0.23616215
135PAK30.23346164
136BMX0.21864036
137PRKACA0.21688087
138CDK90.20838459
139NTRK20.20378206
140CSNK1G20.20115314
141LATS20.19972892
142PRKCB0.19317030
143NEK10.18552695
144PRKACB0.18269010

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.41536218
2Nitrogen metabolism_Homo sapiens_hsa009103.64409419
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39428793
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33778389
5Arginine biosynthesis_Homo sapiens_hsa002203.06997169
6* Complement and coagulation cascades_Homo sapiens_hsa046102.74156457
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71674911
8Tryptophan metabolism_Homo sapiens_hsa003802.66484878
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64176069
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61402476
11Fatty acid degradation_Homo sapiens_hsa000712.50381148
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41895762
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24094286
14Butanoate metabolism_Homo sapiens_hsa006502.23559383
15Peroxisome_Homo sapiens_hsa041462.08729132
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05960156
17Propanoate metabolism_Homo sapiens_hsa006401.96641899
18Histidine metabolism_Homo sapiens_hsa003401.89892188
19Chemical carcinogenesis_Homo sapiens_hsa052041.87238502
20PPAR signaling pathway_Homo sapiens_hsa033201.84836390
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.83678973
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83561798
23Fatty acid metabolism_Homo sapiens_hsa012121.81833526
24Staphylococcus aureus infection_Homo sapiens_hsa051501.76040488
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74704295
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73885530
27beta-Alanine metabolism_Homo sapiens_hsa004101.72074794
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.69350745
29Retinol metabolism_Homo sapiens_hsa008301.61424943
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60500357
31Selenocompound metabolism_Homo sapiens_hsa004501.60288700
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58252576
33Caffeine metabolism_Homo sapiens_hsa002321.57978767
34Phenylalanine metabolism_Homo sapiens_hsa003601.54989924
35Bile secretion_Homo sapiens_hsa049761.47736044
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45558895
37Pyruvate metabolism_Homo sapiens_hsa006201.41805913
38Tyrosine metabolism_Homo sapiens_hsa003501.41321813
39Sulfur metabolism_Homo sapiens_hsa009201.38019245
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32949076
41Fatty acid elongation_Homo sapiens_hsa000621.32272357
42Starch and sucrose metabolism_Homo sapiens_hsa005001.25499474
43Steroid biosynthesis_Homo sapiens_hsa001001.23694267
44Biosynthesis of amino acids_Homo sapiens_hsa012301.22659615
45Folate biosynthesis_Homo sapiens_hsa007901.22363743
46Fat digestion and absorption_Homo sapiens_hsa049751.18802803
47ABC transporters_Homo sapiens_hsa020101.17276624
48Carbon metabolism_Homo sapiens_hsa012001.16906803
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.14000198
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06303552
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04170608
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.03927154
53Vitamin B6 metabolism_Homo sapiens_hsa007501.02430877
54Arginine and proline metabolism_Homo sapiens_hsa003301.01458414
55Other glycan degradation_Homo sapiens_hsa005110.99942725
56Sulfur relay system_Homo sapiens_hsa041220.96929543
57Vitamin digestion and absorption_Homo sapiens_hsa049770.94403549
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92942047
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86166881
60Lysine degradation_Homo sapiens_hsa003100.83418199
61One carbon pool by folate_Homo sapiens_hsa006700.78882013
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72724637
63Glutathione metabolism_Homo sapiens_hsa004800.69772816
64Glycerolipid metabolism_Homo sapiens_hsa005610.68429323
65Pentose phosphate pathway_Homo sapiens_hsa000300.60394831
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54957046
67Pertussis_Homo sapiens_hsa051330.52337033
68Fatty acid biosynthesis_Homo sapiens_hsa000610.47640314
69Metabolic pathways_Homo sapiens_hsa011000.47071695
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34862555
71Prion diseases_Homo sapiens_hsa050200.32777589
72N-Glycan biosynthesis_Homo sapiens_hsa005100.30448903
73Galactose metabolism_Homo sapiens_hsa000520.27828504
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26559306
75Fructose and mannose metabolism_Homo sapiens_hsa000510.26215007
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23025566
77Insulin resistance_Homo sapiens_hsa049310.22129970
78Mineral absorption_Homo sapiens_hsa049780.20972776
79Linoleic acid metabolism_Homo sapiens_hsa005910.20642635
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.20616011
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.14684824
82Sphingolipid metabolism_Homo sapiens_hsa006000.11068589
83Glucagon signaling pathway_Homo sapiens_hsa049220.08693997
84AMPK signaling pathway_Homo sapiens_hsa041520.01368098
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2491175
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2443991
87Ether lipid metabolism_Homo sapiens_hsa00565-0.2420338
88Bladder cancer_Homo sapiens_hsa05219-0.2250137
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2056570
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1815959
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1754894
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1748652
93Hepatitis C_Homo sapiens_hsa05160-0.1711677
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1683609
95HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1681439
96Renin-angiotensin system_Homo sapiens_hsa04614-0.1575054
97Regulation of autophagy_Homo sapiens_hsa04140-0.1530231
98Lysosome_Homo sapiens_hsa04142-0.1464977
99African trypanosomiasis_Homo sapiens_hsa05143-0.1452411
100Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1387524
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1302049
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1293294
103Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1172898
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1118241
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1024593
106Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0917230
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0842303
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0661867
109ECM-receptor interaction_Homo sapiens_hsa04512-0.0331678
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0328489
111Amoebiasis_Homo sapiens_hsa05146-0.0122901

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