SERPINH1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.04178190
2chondrocyte proliferation (GO:0035988)4.02231691
3planar cell polarity pathway involved in neural tube closure (GO:0090179)3.68534705
4G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.59295821
5notochord development (GO:0030903)3.58319413
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.36441042
7viral mRNA export from host cell nucleus (GO:0046784)3.34472338
8protein retention in ER lumen (GO:0006621)3.19763770
9positive regulation of vascular permeability (GO:0043117)3.16081389
10cochlea morphogenesis (GO:0090103)3.12795768
11peptidyl-arginine omega-N-methylation (GO:0035247)3.10346639
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08539604
13mitochondrial fusion (GO:0008053)3.05550675
14mitotic chromosome condensation (GO:0007076)3.04070563
15nucleosome disassembly (GO:0006337)3.02688952
16protein-DNA complex disassembly (GO:0032986)3.02688952
17DNA replication initiation (GO:0006270)3.01301791
18kidney mesenchyme development (GO:0072074)3.00816780
19pharyngeal system development (GO:0060037)2.99093029
20Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.95879528
21protein localization to chromosome, centromeric region (GO:0071459)2.94416257
22histone arginine methylation (GO:0034969)2.92199637
23mesenchymal cell proliferation (GO:0010463)2.91011650
24response to gravity (GO:0009629)2.86185203
25negative regulation of fibroblast apoptotic process (GO:2000270)2.84172941
26regulation of establishment of planar polarity (GO:0090175)2.79503176
27mitotic sister chromatid segregation (GO:0000070)2.75683271
28cell proliferation involved in metanephros development (GO:0072203)2.75137963
29lens fiber cell development (GO:0070307)2.74808977
30paraxial mesoderm development (GO:0048339)2.70901687
31keratinocyte proliferation (GO:0043616)2.70363208
32heterochromatin organization (GO:0070828)2.69340646
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66759397
34regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.66404676
35convergent extension (GO:0060026)2.64968043
36phenylpropanoid metabolic process (GO:0009698)2.64851034
37protein localization to microtubule (GO:0035372)2.64189443
38sister chromatid segregation (GO:0000819)2.63834651
39mitotic metaphase plate congression (GO:0007080)2.62999525
40craniofacial suture morphogenesis (GO:0097094)2.61400877
41protoporphyrinogen IX metabolic process (GO:0046501)2.61183643
42cranial suture morphogenesis (GO:0060363)2.59164306
43COPI coating of Golgi vesicle (GO:0048205)2.58540776
44Golgi transport vesicle coating (GO:0048200)2.58540776
45outer ear morphogenesis (GO:0042473)2.55322501
46oligosaccharide biosynthetic process (GO:0009312)2.54941041
47UV protection (GO:0009650)2.54085324
48regulation of G0 to G1 transition (GO:0070316)2.53196939
49regulation of mesoderm development (GO:2000380)2.52331601
50amyloid precursor protein catabolic process (GO:0042987)2.51873771
51protein maturation by protein folding (GO:0022417)2.51625464
52sequestering of actin monomers (GO:0042989)2.51160456
53negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50635624
54heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.50035489
55proline biosynthetic process (GO:0006561)2.49638326
56trophoblast giant cell differentiation (GO:0060707)2.49518800
57cellular protein complex localization (GO:0034629)2.48592165
58positive regulation of osteoblast proliferation (GO:0033690)2.48516847
59mitotic nuclear envelope reassembly (GO:0007084)2.47832595
60nuclear envelope reassembly (GO:0031468)2.47832595
61non-canonical Wnt signaling pathway (GO:0035567)2.46885769
62folic acid metabolic process (GO:0046655)2.46501242
63protein localization to kinetochore (GO:0034501)2.45887624
64pentose-phosphate shunt (GO:0006098)2.45637421
65regulation of cell fate specification (GO:0042659)2.45445849
66DNA damage response, signal transduction resulting in transcription (GO:0042772)2.45072331
67branching involved in salivary gland morphogenesis (GO:0060445)2.43594577
68DNA strand renaturation (GO:0000733)2.43022304
69peptidyl-arginine methylation (GO:0018216)2.42708142
70peptidyl-arginine N-methylation (GO:0035246)2.42708142
71DNA strand elongation involved in DNA replication (GO:0006271)2.41780276
72DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.41309737
73DNA replication checkpoint (GO:0000076)2.40461193
74DNA strand elongation (GO:0022616)2.40072115
75collagen fibril organization (GO:0030199)2.37698723
76cell proliferation in forebrain (GO:0021846)2.36379767
77protein complex localization (GO:0031503)2.35737988
78negative regulation of chondrocyte differentiation (GO:0032331)2.32364598
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.32223519
80establishment of planar polarity (GO:0001736)2.30741313
81establishment of tissue polarity (GO:0007164)2.30741313
82meiotic chromosome segregation (GO:0045132)2.29749904
83renal system development (GO:0072001)2.29742605
84establishment of integrated proviral latency (GO:0075713)2.28521441
85chaperone-mediated protein complex assembly (GO:0051131)2.27696963
86regulation of cardioblast proliferation (GO:0003264)2.26505156
87regulation of secondary heart field cardioblast proliferation (GO:0003266)2.26505156
88hindlimb morphogenesis (GO:0035137)2.25595713
89ribosomal small subunit assembly (GO:0000028)2.23526688
90positive regulation of SMAD protein import into nucleus (GO:0060391)2.23286647
91protein heterotrimerization (GO:0070208)2.23052993
92replication fork processing (GO:0031297)2.22482771
93urinary tract smooth muscle contraction (GO:0014848)2.22260988
94positive regulation of gastrulation (GO:2000543)2.22090754
95glucocorticoid receptor signaling pathway (GO:0042921)2.21798325
96regulation of translational termination (GO:0006449)2.21570291
97pattern specification involved in kidney development (GO:0061004)2.21354899
98NADPH regeneration (GO:0006740)2.19617979
99chondrocyte development (GO:0002063)2.18423480
100cell proliferation involved in kidney development (GO:0072111)2.18239957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.35817493
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.36181901
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22668067
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.17511771
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.83928465
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43204265
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38767118
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22702447
9CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.19499797
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18763403
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13512546
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12581844
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11009369
14XRN2_22483619_ChIP-Seq_HELA_Human2.09933346
15NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96400765
16MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93749915
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.92445660
18MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89542331
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.87584920
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.84185535
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78633630
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72171249
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71474396
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71342621
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67817015
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60904780
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58873283
28TTF2_22483619_ChIP-Seq_HELA_Human1.57732287
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56766652
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56501498
31KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56439434
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56302304
33AR_21909140_ChIP-Seq_LNCAP_Human1.53640468
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52026069
35DCP1A_22483619_ChIP-Seq_HELA_Human1.51595415
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49974252
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49283967
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.48381219
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.48307009
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.43783740
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43454911
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.42647406
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41872312
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41754691
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.41698835
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38621304
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35903784
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35235405
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.35191788
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35033565
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.34912516
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34209429
53TP53_22127205_ChIP-Seq_IMR90_Human1.33066590
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31680417
55ZNF263_19887448_ChIP-Seq_K562_Human1.29493728
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29262464
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28927409
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28019175
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27570362
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26769963
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26611656
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25854377
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23960681
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22851544
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22700515
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20453018
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19126938
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18781658
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18546822
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.17235982
71RACK7_27058665_Chip-Seq_MCF-7_Human1.16615147
72GABP_19822575_ChIP-Seq_HepG2_Human1.15128579
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14638950
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13577411
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.13214227
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11605611
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10662432
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10313158
79MYC_22102868_ChIP-Seq_BL_Human1.09347272
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08302597
81KDM5A_27292631_Chip-Seq_BREAST_Human1.07551419
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07478534
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06846561
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.06747247
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06326449
86FOXP1_21924763_ChIP-Seq_HESCs_Human1.06157424
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.06025023
88LXR_22292898_ChIP-Seq_THP-1_Human1.04872154
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04531094
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03048306
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.02556168
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02513350
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.02208794
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02011739
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.01723821
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.00142421
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99867055
98TET1_21451524_ChIP-Seq_MESCs_Mouse0.99169798
99CLOCK_20551151_ChIP-Seq_293T_Human0.98356882
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97379320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.33109537
2MP0008438_abnormal_cutaneous_collagen3.67808419
3MP0003705_abnormal_hypodermis_morpholog2.98532545
4MP0000566_synostosis2.58994493
5MP0003136_yellow_coat_color2.53896984
6MP0000049_abnormal_middle_ear2.37973006
7MP0005171_absent_coat_pigmentation2.31083414
8MP0001299_abnormal_eye_distance/2.29000726
9MP0009384_cardiac_valve_regurgitation2.21290390
10MP0002089_abnormal_postnatal_growth/wei2.20742780
11MP0005623_abnormal_meninges_morphology2.20052133
12MP0005503_abnormal_tendon_morphology2.19849050
13MP0004272_abnormal_basement_membrane2.06897488
14MP0008789_abnormal_olfactory_epithelium2.04456242
15MP0001529_abnormal_vocalization2.01913688
16MP0000537_abnormal_urethra_morphology1.99156863
17MP0005257_abnormal_intraocular_pressure1.92760263
18MP0008932_abnormal_embryonic_tissue1.79676609
19MP0003937_abnormal_limbs/digits/tail_de1.78178102
20MP0003283_abnormal_digestive_organ1.77505318
21MP0000428_abnormal_craniofacial_morphol1.77213857
22MP0004134_abnormal_chest_morphology1.76530636
23MP0003111_abnormal_nucleus_morphology1.76466435
24MP0003566_abnormal_cell_adhesion1.74959684
25MP0009250_abnormal_appendicular_skeleto1.74396148
26MP0004957_abnormal_blastocyst_morpholog1.71155203
27MP0010094_abnormal_chromosome_stability1.68606691
28MP0003942_abnormal_urinary_system1.67767096
29MP0000762_abnormal_tongue_morphology1.66569428
30MP0003755_abnormal_palate_morphology1.59366306
31MP0000534_abnormal_ureter_morphology1.54386740
32MP0003077_abnormal_cell_cycle1.49763473
33MP0004133_heterotaxia1.42844883
34MP0005508_abnormal_skeleton_morphology1.42517799
35MP0003656_abnormal_erythrocyte_physiolo1.34911151
36MP0003385_abnormal_body_wall1.34844988
37MP0002085_abnormal_embryonic_tissue1.34052399
38MP0005451_abnormal_body_composition1.33210151
39MP0003693_abnormal_embryo_hatching1.26493380
40MP0001958_emphysema1.26324763
41MP0000733_abnormal_muscle_development1.26208050
42MP0001346_abnormal_lacrimal_gland1.26049922
43MP0002249_abnormal_larynx_morphology1.23963273
44MP0005076_abnormal_cell_differentiation1.23705051
45MP0002111_abnormal_tail_morphology1.23109301
46MP0002084_abnormal_developmental_patter1.21500463
47MP0003935_abnormal_craniofacial_develop1.19798621
48MP0005394_taste/olfaction_phenotype1.17093766
49MP0005499_abnormal_olfactory_system1.17093766
50MP0004233_abnormal_muscle_weight1.15692567
51MP0003279_aneurysm1.15227852
52MP0002653_abnormal_ependyma_morphology1.13154693
53MP0002932_abnormal_joint_morphology1.12795350
54MP0002108_abnormal_muscle_morphology1.12401448
55MP0002938_white_spotting1.12311031
56MP0002233_abnormal_nose_morphology1.12060630
57MP0000751_myopathy1.10201466
58MP0000749_muscle_degeneration1.09211680
59MP0002116_abnormal_craniofacial_bone1.08988372
60MP0000747_muscle_weakness1.06516418
61MP0002896_abnormal_bone_mineralization1.05674424
62MP0000163_abnormal_cartilage_morphology1.05197493
63MP0000350_abnormal_cell_proliferation1.05148276
64MP0005380_embryogenesis_phenotype1.04692877
65MP0001672_abnormal_embryogenesis/_devel1.04692877
66MP0002877_abnormal_melanocyte_morpholog1.04303383
67MP0002282_abnormal_trachea_morphology1.04048449
68MP0001243_abnormal_dermal_layer1.02772483
69MP0002177_abnormal_outer_ear1.01886197
70MP0009053_abnormal_anal_canal1.01667111
71MP0000759_abnormal_skeletal_muscle0.99896745
72MP0003115_abnormal_respiratory_system0.99355443
73MP0004197_abnormal_fetal_growth/weight/0.97981379
74MP0000432_abnormal_head_morphology0.97832438
75MP0003984_embryonic_growth_retardation0.97108204
76MP0004185_abnormal_adipocyte_glucose0.96957482
77MP0002080_prenatal_lethality0.96667648
78MP0010368_abnormal_lymphatic_system0.95910203
79MP0001849_ear_inflammation0.93663653
80MP0003861_abnormal_nervous_system0.92907841
81MP0003091_abnormal_cell_migration0.92885530
82MP0002697_abnormal_eye_size0.92809033
83MP0001286_abnormal_eye_development0.92650602
84MP0002088_abnormal_embryonic_growth/wei0.89673387
85MP0002114_abnormal_axial_skeleton0.87044683
86MP0003959_abnormal_lean_body0.86524606
87MP0003786_premature_aging0.85913399
88MP0001730_embryonic_growth_arrest0.85228099
89MP0000462_abnormal_digestive_system0.85114921
90MP0000003_abnormal_adipose_tissue0.84900112
91MP0005275_abnormal_skin_tensile0.83395755
92MP0001697_abnormal_embryo_size0.83387095
93MP0001542_abnormal_bone_strength0.79646185
94MP0000613_abnormal_salivary_gland0.77787788
95MP0002086_abnormal_extraembryonic_tissu0.73641395
96MP0002113_abnormal_skeleton_development0.72517422
97MP0002081_perinatal_lethality0.72372490
98MP0005501_abnormal_skin_physiology0.72362458
99MP0000467_abnormal_esophagus_morphology0.71389614
100MP0003119_abnormal_digestive_system0.70107966

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.90246512
2Protrusio acetabuli (HP:0003179)3.40978155
3Abnormality of dentin (HP:0010299)3.34981760
4Short 4th metacarpal (HP:0010044)3.19564231
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.19564231
6Broad face (HP:0000283)3.18735311
7Abnormal number of erythroid precursors (HP:0012131)3.08252908
8Breech presentation (HP:0001623)3.06194848
9Aplasia involving bones of the extremities (HP:0009825)3.01132112
10Aplasia involving bones of the upper limbs (HP:0009823)3.01132112
11Aplasia of the phalanges of the hand (HP:0009802)3.01132112
12Large earlobe (HP:0009748)2.91181548
13Shallow orbits (HP:0000586)2.74783340
14Abnormality of cells of the erythroid lineage (HP:0012130)2.74052290
15Broad metatarsal (HP:0001783)2.66859710
16Turricephaly (HP:0000262)2.62634122
17Abnormal number of incisors (HP:0011064)2.59684791
18Coronal craniosynostosis (HP:0004440)2.59165969
19Conjunctival hamartoma (HP:0100780)2.52796199
20Soft skin (HP:0000977)2.46520717
21Broad distal phalanx of finger (HP:0009836)2.44949024
22Meningioma (HP:0002858)2.44601507
23Abnormal umbilical cord blood vessels (HP:0011403)2.40618097
24Single umbilical artery (HP:0001195)2.40618097
25Abnormality of the fetal cardiovascular system (HP:0010948)2.40618097
26Ulnar bowing (HP:0003031)2.35977946
27Biconcave vertebral bodies (HP:0004586)2.35953238
28Neonatal short-limb short stature (HP:0008921)2.31047226
29Urethral obstruction (HP:0000796)2.29116449
30Down-sloping shoulders (HP:0200021)2.28128394
31Duplication of thumb phalanx (HP:0009942)2.27181591
32Ankle contracture (HP:0006466)2.26010850
33Partial duplication of the phalanx of hand (HP:0009999)2.24839957
34Trigonocephaly (HP:0000243)2.24523680
35Bladder diverticulum (HP:0000015)2.20301373
36Abnormality of the distal phalanx of the thumb (HP:0009617)2.19137429
37Abnormality of the 4th metacarpal (HP:0010012)2.16006481
38Abnormality of the umbilical cord (HP:0010881)2.15997845
39Breast hypoplasia (HP:0003187)2.11583969
40High anterior hairline (HP:0009890)2.08411555
41Birth length less than 3rd percentile (HP:0003561)2.08166560
42Short nail (HP:0001799)2.07415445
43Calcaneovalgus deformity (HP:0001848)2.04653721
44Reticulocytosis (HP:0001923)2.02657522
45Spinal rigidity (HP:0003306)2.02224761
46Genu recurvatum (HP:0002816)2.01178511
47Joint laxity (HP:0001388)1.98176519
48Premature skin wrinkling (HP:0100678)1.96184568
49Hyperacusis (HP:0010780)1.96148174
50Broad toe (HP:0001837)1.95306326
51Elbow flexion contracture (HP:0002987)1.94224280
52Redundant skin (HP:0001582)1.93709731
53Bone cyst (HP:0012062)1.91337510
54Fibular hypoplasia (HP:0003038)1.90937046
55Benign neoplasm of the central nervous system (HP:0100835)1.90685510
56Partial duplication of thumb phalanx (HP:0009944)1.90458828
57Type 1 muscle fiber predominance (HP:0003803)1.90240718
58Wormian bones (HP:0002645)1.90023417
59Insomnia (HP:0100785)1.89928601
60Mesomelia (HP:0003027)1.89827782
61Termporal pattern (HP:0011008)1.89743290
62Insidious onset (HP:0003587)1.89743290
63Increased connective tissue (HP:0009025)1.89622130
64Hypoplastic pelvis (HP:0008839)1.89537850
65Aplasia/Hypoplasia of the patella (HP:0006498)1.89165472
66Patellar aplasia (HP:0006443)1.88801892
67Abnormality of reticulocytes (HP:0004312)1.86751412
68Esophageal atresia (HP:0002032)1.86208436
69Aplasia/Hypoplasia of the fibula (HP:0006492)1.85844322
70Broad hallux (HP:0010055)1.84949071
71Selective tooth agenesis (HP:0001592)1.84403326
72Infantile muscular hypotonia (HP:0008947)1.80737714
73Midface retrusion (HP:0011800)1.79612759
74Broad ribs (HP:0000885)1.79259726
75Bowing of the arm (HP:0006488)1.78589660
76Bowed forearm bones (HP:0003956)1.78589660
77Fragile skin (HP:0001030)1.77620167
78Slender long bone (HP:0003100)1.77556634
79Abnormality of the parietal bone (HP:0002696)1.77249226
80Hypoventilation (HP:0002791)1.76803945
81Deformed tarsal bones (HP:0008119)1.75568328
82Bell-shaped thorax (HP:0001591)1.75461862
83Shoulder girdle muscle weakness (HP:0003547)1.73113509
84Vascular tortuosity (HP:0004948)1.72961392
85Abnormal ossification of hand bones (HP:0005921)1.72654231
86Atrophic scars (HP:0001075)1.70456075
87Abnormality of the calcaneus (HP:0008364)1.70203194
88Back pain (HP:0003418)1.69245538
89Hydroureter (HP:0000072)1.68937670
90Abnormal delivery (HP:0001787)1.68607338
91Camptodactyly of toe (HP:0001836)1.67545197
92Increased serum pyruvate (HP:0003542)1.66772877
93Chin dimple (HP:0010751)1.66578894
94Cervical subluxation (HP:0003308)1.65964959
95Round ear (HP:0100830)1.65818942
96Arterial tortuosity (HP:0005116)1.65741243
97Nonimmune hydrops fetalis (HP:0001790)1.65506018
98Aortic dissection (HP:0002647)1.65167800
99Microglossia (HP:0000171)1.63286446
100Abnormality of the proximal phalanges of the hand (HP:0009834)1.60974130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.85843303
2TRIB33.04098135
3SMG13.03260161
4LMTK22.55500742
5SIK12.40455028
6INSRR2.28323384
7VRK22.20373919
8LATS12.08977799
9PIM22.07744808
10PNCK1.96611293
11TSSK61.77463306
12EPHA21.70868447
13CDK81.69241017
14MAP4K21.64141757
15TESK21.59196497
16WEE11.58102599
17EIF2AK11.55982536
18PAK41.54733020
19NEK91.54123146
20CDC71.53943143
21EEF2K1.53317346
22EPHB21.51835271
23CHEK21.46398033
24CASK1.42872659
25BUB11.40783496
26BCKDK1.37097463
27AURKA1.36073998
28PAK21.35983516
29TTK1.34372542
30EPHA31.29535671
31PLK41.26373081
32TESK11.24943451
33ICK1.24692295
34PTK21.23739137
35TAOK21.22740392
36NTRK11.21623887
37MET1.19429062
38BMX1.17347283
39MAPK151.15959527
40LIMK11.15581282
41TTN1.11951199
42STK161.08631204
43CDK71.07439347
44LATS21.05646309
45CDK121.04452900
46PBK1.02618074
47ZAK1.02322418
48DYRK30.99312760
49MAP2K70.96070510
50SIK20.95012842
51VRK10.92414776
52MAP3K80.90829226
53PRPF4B0.88130594
54ILK0.86635101
55PDGFRA0.86422705
56STK40.82569308
57BRSK10.82462115
58MKNK10.80813151
59PLK10.78387675
60PHKG20.76902050
61PHKG10.76902050
62PLK30.73615936
63RPS6KA40.72308282
64PKN20.71510577
65NUAK10.71248750
66ERBB40.71117391
67DDR20.70918591
68TAF10.69506880
69CAMK1D0.68812678
70AURKB0.65776524
71MUSK0.65605590
72RAF10.65312627
73SCYL20.64351726
74NEK20.63482673
75ATR0.62682585
76MELK0.62169343
77RPS6KA50.61926197
78MST1R0.61735889
79MOS0.61600229
80MAPK110.60751377
81TIE10.60066367
82MAP3K100.59316711
83IRAK30.59074371
84CAMK1G0.58248110
85MTOR0.57273270
86MYLK0.56712534
87AKT20.55898344
88MKNK20.52457992
89MAP2K20.50984800
90STK380.50620043
91DAPK30.46068109
92MAPKAPK50.45492514
93NEK10.45461952
94CSNK1A1L0.44983264
95PTK60.44361656
96TLK10.42541390
97CDK40.42125626
98EPHA40.42054704
99ABL20.41976429
100CDK150.41368165

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.95974681
2Basal cell carcinoma_Homo sapiens_hsa052172.93155605
3DNA replication_Homo sapiens_hsa030302.61703383
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.56476079
5Hedgehog signaling pathway_Homo sapiens_hsa043402.52117270
6Cell cycle_Homo sapiens_hsa041102.21175780
7Hippo signaling pathway_Homo sapiens_hsa043901.93888103
8Bladder cancer_Homo sapiens_hsa052191.92971623
9Spliceosome_Homo sapiens_hsa030401.89014427
10Mismatch repair_Homo sapiens_hsa034301.84157944
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83974806
12Ribosome_Homo sapiens_hsa030101.83720080
13Biosynthesis of amino acids_Homo sapiens_hsa012301.78493475
14Melanoma_Homo sapiens_hsa052181.71066463
15Base excision repair_Homo sapiens_hsa034101.67295722
16Folate biosynthesis_Homo sapiens_hsa007901.67023183
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66781210
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63475483
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.53567185
20TGF-beta signaling pathway_Homo sapiens_hsa043501.52354641
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51563538
22ECM-receptor interaction_Homo sapiens_hsa045121.49254514
23Small cell lung cancer_Homo sapiens_hsa052221.48251873
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45992402
25RNA transport_Homo sapiens_hsa030131.44749075
26Wnt signaling pathway_Homo sapiens_hsa043101.42098401
27Steroid biosynthesis_Homo sapiens_hsa001001.40257917
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33961296
29MicroRNAs in cancer_Homo sapiens_hsa052061.26901100
30mRNA surveillance pathway_Homo sapiens_hsa030151.25420034
31Proteoglycans in cancer_Homo sapiens_hsa052051.23709611
32p53 signaling pathway_Homo sapiens_hsa041151.20748507
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17813613
34N-Glycan biosynthesis_Homo sapiens_hsa005101.17772343
35Carbon metabolism_Homo sapiens_hsa012001.17758404
36Focal adhesion_Homo sapiens_hsa045101.16983456
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15329262
38Pyrimidine metabolism_Homo sapiens_hsa002401.13609862
39Nucleotide excision repair_Homo sapiens_hsa034201.13545217
40One carbon pool by folate_Homo sapiens_hsa006701.10231348
41Fanconi anemia pathway_Homo sapiens_hsa034601.08461452
42Prostate cancer_Homo sapiens_hsa052151.06587705
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.04773991
44Melanogenesis_Homo sapiens_hsa049161.04219683
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03877543
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02271466
47Chronic myeloid leukemia_Homo sapiens_hsa052200.97908510
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97501150
49Tight junction_Homo sapiens_hsa045300.90490982
50Pathways in cancer_Homo sapiens_hsa052000.86817105
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.86733110
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86152734
53Colorectal cancer_Homo sapiens_hsa052100.84860564
54Endometrial cancer_Homo sapiens_hsa052130.84113689
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83417343
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80294104
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79328480
58Proteasome_Homo sapiens_hsa030500.78048293
59Pentose phosphate pathway_Homo sapiens_hsa000300.76065417
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74787356
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74498725
62Alcoholism_Homo sapiens_hsa050340.73711517
63Axon guidance_Homo sapiens_hsa043600.72745179
64Thyroid cancer_Homo sapiens_hsa052160.72265844
65Adherens junction_Homo sapiens_hsa045200.71358969
66Pyruvate metabolism_Homo sapiens_hsa006200.70124373
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69506768
68Pancreatic cancer_Homo sapiens_hsa052120.68336725
69Homologous recombination_Homo sapiens_hsa034400.68296663
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68106654
71HTLV-I infection_Homo sapiens_hsa051660.66818846
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65905635
73Notch signaling pathway_Homo sapiens_hsa043300.64050239
74AMPK signaling pathway_Homo sapiens_hsa041520.63640624
75Oocyte meiosis_Homo sapiens_hsa041140.62360787
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58681355
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58037328
78Non-small cell lung cancer_Homo sapiens_hsa052230.57337646
79Viral carcinogenesis_Homo sapiens_hsa052030.55790945
80Basal transcription factors_Homo sapiens_hsa030220.55150415
81Glioma_Homo sapiens_hsa052140.53028015
82Fatty acid elongation_Homo sapiens_hsa000620.50858141
83Huntingtons disease_Homo sapiens_hsa050160.50559120
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50020349
85Protein digestion and absorption_Homo sapiens_hsa049740.49747694
86Lysine degradation_Homo sapiens_hsa003100.49509044
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48291311
88ErbB signaling pathway_Homo sapiens_hsa040120.45922696
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45555935
90RNA polymerase_Homo sapiens_hsa030200.45309026
91Glucagon signaling pathway_Homo sapiens_hsa049220.44629840
92Selenocompound metabolism_Homo sapiens_hsa004500.44394994
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42850803
94Estrogen signaling pathway_Homo sapiens_hsa049150.42613276
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.41796464
96Dilated cardiomyopathy_Homo sapiens_hsa054140.41046329
97Gap junction_Homo sapiens_hsa045400.40707751
98Systemic lupus erythematosus_Homo sapiens_hsa053220.37210495
99Fructose and mannose metabolism_Homo sapiens_hsa000510.35701201
100VEGF signaling pathway_Homo sapiens_hsa043700.35162197

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