SERPINI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)8.88461686
2epithelial cilium movement (GO:0003351)8.84478298
3cobalamin metabolic process (GO:0009235)8.32022171
4transcytosis (GO:0045056)8.05650516
5cholesterol catabolic process (GO:0006707)7.85307513
6sterol catabolic process (GO:0016127)7.85307513
7intestinal absorption (GO:0050892)7.52451549
8peptidyl-proline hydroxylation (GO:0019511)7.48213498
9regulation of phospholipase A2 activity (GO:0032429)7.05333388
10axoneme assembly (GO:0035082)6.81390905
11negative regulation of digestive system process (GO:0060457)6.76934052
12cysteine metabolic process (GO:0006534)6.74821514
13glycolipid catabolic process (GO:0019377)6.53927452
14membrane lipid catabolic process (GO:0046466)6.22119472
15proline biosynthetic process (GO:0006561)6.11502686
16branched-chain amino acid catabolic process (GO:0009083)6.00902468
17left/right axis specification (GO:0070986)5.99620662
18protein hydroxylation (GO:0018126)5.75304111
19valine metabolic process (GO:0006573)5.65508876
20regulation of cilium movement (GO:0003352)5.63055689
21negative regulation of epidermis development (GO:0045683)5.61215062
22ceramide catabolic process (GO:0046514)5.47226201
23Golgi transport vesicle coating (GO:0048200)5.44028697
24COPI coating of Golgi vesicle (GO:0048205)5.44028697
25phosphatidylinositol acyl-chain remodeling (GO:0036149)5.32490457
26cellular modified amino acid catabolic process (GO:0042219)5.24591659
27branched-chain amino acid metabolic process (GO:0009081)5.23459877
28phosphatidylserine acyl-chain remodeling (GO:0036150)5.13735284
29serine family amino acid biosynthetic process (GO:0009070)5.06457123
30mitochondrial calcium ion transport (GO:0006851)5.05291470
31zinc ion transport (GO:0006829)4.87061487
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.82155844
33positive regulation of heat generation (GO:0031652)4.75246713
34left/right pattern formation (GO:0060972)4.71679792
35protein maturation by protein folding (GO:0022417)4.71082522
36ventricular system development (GO:0021591)4.69054376
37homocysteine metabolic process (GO:0050667)4.64631120
38positive regulation of nuclease activity (GO:0032075)4.61923039
39aspartate family amino acid catabolic process (GO:0009068)4.58451859
40regulation of fever generation (GO:0031620)4.58000924
41phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.55982341
42leukotriene biosynthetic process (GO:0019370)4.54052780
43response to endoplasmic reticulum stress (GO:0034976)4.53091117
44endoplasmic reticulum unfolded protein response (GO:0030968)4.37162975
45intraciliary transport (GO:0042073)4.27245102
46cilium organization (GO:0044782)4.25270430
47cellular response to unfolded protein (GO:0034620)4.24783226
48glutamine metabolic process (GO:0006541)4.23735474
49signal peptide processing (GO:0006465)4.23432170
50maintenance of protein localization in organelle (GO:0072595)4.23279133
514-hydroxyproline metabolic process (GO:0019471)4.21252695
52regulation of nuclease activity (GO:0032069)4.20552701
53intestinal epithelial cell development (GO:0060576)4.19206601
54L-serine metabolic process (GO:0006563)4.17329100
55proline metabolic process (GO:0006560)4.14700733
56neutrophil mediated immunity (GO:0002446)4.08056082
57primary alcohol catabolic process (GO:0034310)4.05439079
58cellular response to topologically incorrect protein (GO:0035967)4.04232526
59ER-nucleus signaling pathway (GO:0006984)4.02467112
60cilium assembly (GO:0042384)3.99019209
61creatine metabolic process (GO:0006600)3.96181208
62steroid catabolic process (GO:0006706)3.95445620
63innate immune response in mucosa (GO:0002227)3.94339009
64GDP-mannose metabolic process (GO:0019673)3.92724468
65coenzyme catabolic process (GO:0009109)3.90255098
66serine family amino acid metabolic process (GO:0009069)3.90004687
67negative regulation of epidermal cell differentiation (GO:0045605)3.83022632
68mitochondrion distribution (GO:0048311)3.82071548
69phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.81659418
70L-phenylalanine catabolic process (GO:0006559)3.78236060
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.78236060
72regulation of keratinocyte proliferation (GO:0010837)3.72836825
73regulation of heat generation (GO:0031650)3.63885236
74ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.63443131
75mucosal immune response (GO:0002385)3.62370905
76COPII vesicle coating (GO:0048208)3.60976757
77L-phenylalanine metabolic process (GO:0006558)3.58612010
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.58612010
79antibacterial humoral response (GO:0019731)3.52593716
80inositol metabolic process (GO:0006020)3.49802700
81preassembly of GPI anchor in ER membrane (GO:0016254)3.49641597
82sphingolipid catabolic process (GO:0030149)3.49638142
83icosanoid transport (GO:0071715)3.49548421
84fatty acid derivative transport (GO:1901571)3.49548421
85vitamin transmembrane transport (GO:0035461)3.49436092
86ER overload response (GO:0006983)3.46406140
87response to unfolded protein (GO:0006986)3.46098025
88phosphatidylserine metabolic process (GO:0006658)3.45284946
89regulation of keratinocyte differentiation (GO:0045616)3.42330977
90phosphatidylcholine acyl-chain remodeling (GO:0036151)3.40802378
91sulfur amino acid biosynthetic process (GO:0000097)3.40549675
92regulation of microtubule-based movement (GO:0060632)3.38729791
93endocrine pancreas development (GO:0031018)3.36417398
94protein N-linked glycosylation via asparagine (GO:0018279)3.35893894
95glycine metabolic process (GO:0006544)3.34675887
96peptidyl-asparagine modification (GO:0018196)3.33523268
97response to topologically incorrect protein (GO:0035966)3.33350357
98polarized epithelial cell differentiation (GO:0030859)3.30718171
99microtubule bundle formation (GO:0001578)3.28918307
100cell redox homeostasis (GO:0045454)3.28118572
101digestive system process (GO:0022600)3.26970301
102antimicrobial humoral response (GO:0019730)3.25392284
103organ or tissue specific immune response (GO:0002251)3.25083590
104alpha-amino acid biosynthetic process (GO:1901607)3.22192476
105regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.21212162
106regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.18943177
107retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18077145
108cellular component assembly involved in morphogenesis (GO:0010927)3.16919409
109arachidonic acid secretion (GO:0050482)3.16821428
110icosanoid secretion (GO:0032309)3.16821428
111retinoic acid receptor signaling pathway (GO:0048384)3.15405179
112biotin metabolic process (GO:0006768)3.15297897
113activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.14684195
114glycine transport (GO:0015816)3.11773384
115myeloid leukocyte mediated immunity (GO:0002444)3.09057921
116cellular protein catabolic process (GO:0044257)3.07002843
117protein N-linked glycosylation (GO:0006487)3.06830729
118negative regulation of granulocyte differentiation (GO:0030853)3.03738768
119protein localization to cilium (GO:0061512)3.01565275
120cholesterol transport (GO:0030301)3.00219248
121sterol transport (GO:0015918)3.00219248
122alditol phosphate metabolic process (GO:0052646)2.98210957
123regulation of oxidative stress-induced cell death (GO:1903201)2.96899902
124nonmotile primary cilium assembly (GO:0035058)2.95677849
125aspartate family amino acid metabolic process (GO:0009066)2.95513979
126L-alpha-amino acid transmembrane transport (GO:1902475)2.94791980
127tetrapyrrole metabolic process (GO:0033013)2.94030916
128one-carbon metabolic process (GO:0006730)2.93978839
129negative regulation of cell fate commitment (GO:0010454)2.93284651
130phosphatidic acid biosynthetic process (GO:0006654)2.92975542
131phosphatidic acid metabolic process (GO:0046473)2.92975542
132retinal rod cell development (GO:0046548)2.91685387
133peptidyl-proline modification (GO:0018208)2.91412190
134pancreas development (GO:0031016)2.90512217
135epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.88978173
136cilium morphogenesis (GO:0060271)2.88860466
137negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86923431
138ethanol metabolic process (GO:0006067)2.82382841
139cellular response to exogenous dsRNA (GO:0071360)2.82123479
140photoreceptor cell maintenance (GO:0045494)2.73410462
141L-ascorbic acid metabolic process (GO:0019852)2.73320243
142cell projection assembly (GO:0030031)2.70166597
143GPI anchor biosynthetic process (GO:0006506)2.64943606
144smoothened signaling pathway (GO:0007224)2.64190004
145microtubule-based movement (GO:0007018)2.63902835
146autophagic vacuole fusion (GO:0000046)2.59021238
147water-soluble vitamin metabolic process (GO:0006767)2.54408066
148GPI anchor metabolic process (GO:0006505)2.53717640
149glutathione derivative metabolic process (GO:1901685)2.53131141
150glutathione derivative biosynthetic process (GO:1901687)2.53131141
151phosphatidylglycerol metabolic process (GO:0046471)2.49847255
152retinoid metabolic process (GO:0001523)2.48255450
153determination of left/right symmetry (GO:0007368)2.48074303
154sulfation (GO:0051923)2.48030017
155sperm capacitation (GO:0048240)2.47907746
156inositol phosphate dephosphorylation (GO:0046855)2.47495202
157phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47495202
158alcohol catabolic process (GO:0046164)2.45795729
159response to xenobiotic stimulus (GO:0009410)2.45614602
160diterpenoid biosynthetic process (GO:0016102)2.42374690
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.37369721
162phototransduction, visible light (GO:0007603)2.36840304
163determination of bilateral symmetry (GO:0009855)2.35827427
164heart looping (GO:0001947)2.34482191
165one-carbon compound transport (GO:0019755)2.34482054
166reflex (GO:0060004)2.34312531
167intestinal cholesterol absorption (GO:0030299)17.6580011
168exocrine pancreas development (GO:0031017)16.8741120
169digestion (GO:0007586)14.1439533
170protein retention in ER lumen (GO:0006621)12.4786606
171maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.6304759
172cilium or flagellum-dependent cell motility (GO:0001539)11.5505939
173axonemal dynein complex assembly (GO:0070286)11.4758016
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.2914636
175cilium movement (GO:0003341)10.2206181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.48489455
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.32334861
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.98744875
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.75174747
5ERG_21242973_ChIP-ChIP_JURKAT_Human3.45988821
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.31837333
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.84970221
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.80622172
9VDR_22108803_ChIP-Seq_LS180_Human2.74604331
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.65814929
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.60382518
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52166380
13GATA4_25053715_ChIP-Seq_YYC3_Human2.50013172
14IGF1R_20145208_ChIP-Seq_DFB_Human2.33935918
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.27410362
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.27410362
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.27410362
18SOX2_27498859_Chip-Seq_STOMACH_Mouse2.21494628
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21363483
20GBX2_23144817_ChIP-Seq_PC3_Human2.21139156
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19496398
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18598016
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.15628179
24PIAS1_25552417_ChIP-Seq_VCAP_Human2.15470919
25PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.13258478
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.12626513
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04727140
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.04452672
29GATA6_25053715_ChIP-Seq_YYC3_Human2.00552208
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99017836
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98079878
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.96716369
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.91586431
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91092287
35* P300_19829295_ChIP-Seq_ESCs_Human1.91030372
36FUS_26573619_Chip-Seq_HEK293_Human1.87820418
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85000112
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81955992
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.80414719
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79391150
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73746743
42BCAT_22108803_ChIP-Seq_LS180_Human1.71300044
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70972931
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68940401
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67966956
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.67719560
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.65123842
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62517270
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62316425
50ER_23166858_ChIP-Seq_MCF-7_Human1.59260458
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.56879869
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54751364
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54609921
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53575899
55SMAD4_21799915_ChIP-Seq_A2780_Human1.53087465
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.50123001
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49465664
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46273270
59ETV1_20927104_ChIP-Seq_GIST48_Human1.44770323
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42448653
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.41064654
62TAF15_26573619_Chip-Seq_HEK293_Human1.40991241
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.40493881
64STAT3_23295773_ChIP-Seq_U87_Human1.40420477
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39517281
66CHD1_26751641_Chip-Seq_LNCaP_Human1.39067234
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37421696
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.35917503
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35566765
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.31924785
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31809873
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.31809873
73TP53_18474530_ChIP-ChIP_U2OS_Human1.31765914
74EGR1_19032775_ChIP-ChIP_M12_Human1.31605113
75PHF8_20622853_ChIP-Seq_HELA_Human1.31597372
76GATA1_22025678_ChIP-Seq_K562_Human1.31468070
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.30915365
78CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30438513
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.30305324
80ESET_19884257_ChIP-Seq_ESCs_Mouse1.29964061
81HNFA_21074721_ChIP-Seq_CACO-2_Human1.28998389
82P68_20966046_ChIP-Seq_HELA_Human1.28789556
83CDX2_22108803_ChIP-Seq_LS180_Human1.27560454
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26303051
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26303051
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25301791
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24633386
88CREB1_26743006_Chip-Seq_LNCaP_Human1.24586172
89TCF4_22108803_ChIP-Seq_LS180_Human1.23556540
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22793951
91* NANOG_19829295_ChIP-Seq_ESCs_Human1.22506670
92* SOX2_19829295_ChIP-Seq_ESCs_Human1.22506670
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21359615
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20910825
95LXR_22292898_ChIP-Seq_THP-1_Human1.20484038
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20198072
97IRF1_19129219_ChIP-ChIP_H3396_Human1.19996511
98AHR_22903824_ChIP-Seq_MCF-7_Human1.19974772
99RBPJ_21746931_ChIP-Seq_IB4_Human1.19611976
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19336760
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18759883
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18619262
103ERA_21632823_ChIP-Seq_H3396_Human1.17817537
104NFYA_21822215_ChIP-Seq_K562_Human1.17291532
105EWS_26573619_Chip-Seq_HEK293_Human1.16675455
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15821251
107AR_25329375_ChIP-Seq_VCAP_Human1.14533821
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.14449239
109RUNX2_22187159_ChIP-Seq_PCA_Human1.13953980
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13465906
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13126117
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12752969
113ETS1_21867929_ChIP-Seq_TH2_Mouse1.12481484
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12098279
115ERG_20517297_ChIP-Seq_VCAP_Human1.10858864
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10714746
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08999432
118DROSHA_22980978_ChIP-Seq_HELA_Human1.08658853
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08367048
120* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08187139
121AR_20517297_ChIP-Seq_VCAP_Human1.07997407
122TAF2_19829295_ChIP-Seq_ESCs_Human1.07927863
123GATA6_21074721_ChIP-Seq_CACO-2_Human1.07563957
124NFYB_21822215_ChIP-Seq_K562_Human1.07227935
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07114707
126ATF3_27146783_Chip-Seq_COLON_Human1.06168640
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05938829
128CBP_20019798_ChIP-Seq_JUKART_Human1.05283276
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05283276
130TCF4_18268006_ChIP-ChIP_LS174T_Human1.05174940
131RXR_22108803_ChIP-Seq_LS180_Human1.04804104
132TP63_22573176_ChIP-Seq_HFKS_Human1.04718365
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04187353
134ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03422361
135NANOG_18555785_Chip-Seq_ESCs_Mouse1.03291465
136SOX2_20726797_ChIP-Seq_SW620_Human1.02313669
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02088210
138TP53_16413492_ChIP-PET_HCT116_Human1.01566402
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00542010
140* TCF4_23295773_ChIP-Seq_U87_Human1.00492063
141GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00032290
142FOXH1_21741376_ChIP-Seq_ESCs_Human0.99602407
143P53_21459846_ChIP-Seq_SAOS-2_Human0.99183915
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98822970
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98573671
146* TP63_23658742_ChIP-Seq_EP156T_Human0.98080455
147TBL1_22424771_ChIP-Seq_293T_Human0.96779263
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95902004
149AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95189806
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94787327
151FOXA1_25552417_ChIP-Seq_VCAP_Human0.93885155
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93464543
153CLOCK_20551151_ChIP-Seq_293T_Human0.92582848
154GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92565499
155BCOR_27268052_Chip-Seq_Bcells_Human0.92514723
156MYC_18555785_ChIP-Seq_MESCs_Mouse0.91128699
157FOXP1_21924763_ChIP-Seq_HESCs_Human0.90345369
158SA1_27219007_Chip-Seq_Bcells_Human0.89895082
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.89651805
160FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89484774
161FOXA2_19822575_ChIP-Seq_HepG2_Human0.88556508
162RUNX1_27514584_Chip-Seq_MCF-7_Human0.87710940
163PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87309058
164DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86954277
165CTCF_27219007_Chip-Seq_Bcells_Human0.86864515
166SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.86798681
167TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84531256
168TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84356389
169CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83495919
170TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82183895
171TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81445561
172CEBPB_22108803_ChIP-Seq_LS180_Human0.81322948
173SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81296568
174KLF4_19829295_ChIP-Seq_ESCs_Human0.81159696
175CTCF_20526341_ChIP-Seq_ESCs_Human0.80940410
176DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80639461
177SOX2_22085726_ChIP-Seq_NPCs_Mouse0.80583249
178* OCT4_20526341_ChIP-Seq_ESCs_Human0.80474038
179ETS1_20019798_ChIP-Seq_JURKAT_Human0.79884929
180KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79531709
181TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77975998
182GATA3_24758297_ChIP-Seq_MCF-7_Human0.76926781
183GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76506261
184ZNF274_21170338_ChIP-Seq_K562_Hela0.76070421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption9.55269585
2MP0005365_abnormal_bile_salt6.91742837
3* MP0005220_abnormal_exocrine_pancreas5.29150197
4MP0003868_abnormal_feces_composition5.11121676
5MP0005084_abnormal_gallbladder_morpholo4.98026796
6MP0005085_abnormal_gallbladder_physiolo3.70392244
7MP0003011_delayed_dark_adaptation3.48114206
8MP0002653_abnormal_ependyma_morphology3.43107770
9MP0002638_abnormal_pupillary_reflex3.04123275
10MP0003136_yellow_coat_color2.75994465
11MP0003959_abnormal_lean_body2.68258751
12MP0002693_abnormal_pancreas_physiology2.65006047
13MP0001664_abnormal_digestion2.64343646
14MP0010386_abnormal_urinary_bladder2.58969244
15MP0000383_abnormal_hair_follicle2.48967767
16MP0002132_abnormal_respiratory_system2.06641941
17MP0008875_abnormal_xenobiotic_pharmacok2.01716062
18MP0005083_abnormal_biliary_tract10.1446690
19MP0003705_abnormal_hypodermis_morpholog1.98395548
20MP0003195_calcinosis1.96417648
21MP0004233_abnormal_muscle_weight1.76487552
22MP0001944_abnormal_pancreas_morphology1.75794661
23MP0002139_abnormal_hepatobiliary_system1.73523522
24MP0005448_abnormal_energy_balance1.71520069
25MP0004264_abnormal_extraembryonic_tissu1.69778667
26MP0002277_abnormal_respiratory_mucosa1.55452388
27MP0003638_abnormal_response/metabolism_1.54944698
28MP0003943_abnormal_hepatobiliary_system1.51671106
29MP0005451_abnormal_body_composition1.51228684
30MP0005253_abnormal_eye_physiology1.47404152
31MP0004043_abnormal_pH_regulation1.42366641
32MP0006072_abnormal_retinal_apoptosis1.42271168
33MP0009379_abnormal_foot_pigmentation1.41141838
34MP0004019_abnormal_vitamin_homeostasis1.40247330
35MP0002118_abnormal_lipid_homeostasis1.38465020
36MP0005332_abnormal_amino_acid1.37551803
37MP0010234_abnormal_vibrissa_follicle1.34928867
38MP0004133_heterotaxia1.29105033
39MP0002282_abnormal_trachea_morphology1.27339577
40MP0005165_increased_susceptibility_to1.19494965
41MP0001501_abnormal_sleep_pattern1.16557592
42MP0002160_abnormal_reproductive_system1.08948037
43MP0000427_abnormal_hair_cycle1.07354759
44MP0001984_abnormal_olfaction1.02956361
45MP0000470_abnormal_stomach_morphology1.01762003
46MP0001873_stomach_inflammation1.01481293
47MP0005408_hypopigmentation1.01290466
48MP0008438_abnormal_cutaneous_collagen1.01228834
49MP0003890_abnormal_embryonic-extraembry1.00747396
50MP0008004_abnormal_stomach_pH1.00329231
51MP0002078_abnormal_glucose_homeostasis0.95866003
52MP0001502_abnormal_circadian_rhythm0.94446453
53MP0000490_abnormal_crypts_of0.92746018
54MP0008789_abnormal_olfactory_epithelium0.88477819
55MP0005535_abnormal_body_temperature0.87522633
56MP0000003_abnormal_adipose_tissue0.86552574
57MP0003806_abnormal_nucleotide_metabolis0.85671719
58MP0003252_abnormal_bile_duct0.85164225
59MP0009384_cardiac_valve_regurgitation0.83033385
60MP0009643_abnormal_urine_homeostasis0.81882435
61MP0008995_early_reproductive_senescence0.75973609
62MP0001765_abnormal_ion_homeostasis0.75491703
63MP0000631_abnormal_neuroendocrine_gland0.73210270
64MP0002138_abnormal_hepatobiliary_system0.72358122
65MP0001485_abnormal_pinna_reflex0.70882924
66MP0003953_abnormal_hormone_level0.70854860
67MP0005551_abnormal_eye_electrophysiolog0.69608987
68MP0003186_abnormal_redox_activity0.69270947
69MP0006054_spinal_hemorrhage0.69113160
70MP0005058_abnormal_lysosome_morphology0.69049084
71MP0005394_taste/olfaction_phenotype0.67629185
72MP0005499_abnormal_olfactory_system0.67629185
73MP0003937_abnormal_limbs/digits/tail_de0.66848717
74MP0001764_abnormal_homeostasis0.66755491
75MP0000538_abnormal_urinary_bladder0.66725358
76MP0005360_urolithiasis0.66362214
77MP0006036_abnormal_mitochondrial_physio0.66261518
78MP0001663_abnormal_digestive_system0.66034373
79MP0002909_abnormal_adrenal_gland0.65708626
80MP0005452_abnormal_adipose_tissue0.65229276
81MP0010329_abnormal_lipoprotein_level0.63636162
82MP0003300_gastrointestinal_ulcer0.62980744
83MP0000613_abnormal_salivary_gland0.62546502
84MP0005391_vision/eye_phenotype0.62034462
85MP0009765_abnormal_xenobiotic_induced0.61211772
86MP0001293_anophthalmia0.60469231
87MP0008961_abnormal_basal_metabolism0.59648594
88MP0002233_abnormal_nose_morphology0.58954969
89MP0005171_absent_coat_pigmentation0.58559351
90MP0005595_abnormal_vascular_smooth0.57867584
91MP0003878_abnormal_ear_physiology0.56679519
92MP0005377_hearing/vestibular/ear_phenot0.56679519
93MP0000598_abnormal_liver_morphology0.56360997
94MP0009046_muscle_twitch0.54883876
95MP0005195_abnormal_posterior_eye0.54726391
96MP0010368_abnormal_lymphatic_system0.54100519
97MP0006082_CNS_inflammation0.54011858
98MP0005389_reproductive_system_phenotype0.53830045
99MP0002089_abnormal_postnatal_growth/wei0.52235234
100MP0005174_abnormal_tail_pigmentation0.52178192
101MP0002928_abnormal_bile_duct0.50701708
102MP0002405_respiratory_system_inflammati0.50317365
103MP0002098_abnormal_vibrissa_morphology0.49605130
104MP0005381_digestive/alimentary_phenotyp0.49391810
105MP0000750_abnormal_muscle_regeneration0.49264988
106MP0005646_abnormal_pituitary_gland0.48612947
107MP0001324_abnormal_eye_pigmentation0.46979341
108MP0005319_abnormal_enzyme/_coenzyme0.46839373
109MP0000609_abnormal_liver_physiology0.45944759
110MP0001845_abnormal_inflammatory_respons0.44538681
111MP0005375_adipose_tissue_phenotype0.42401754
112MP0002796_impaired_skin_barrier0.42201212
113MP0001286_abnormal_eye_development0.40578533
114MP0000465_gastrointestinal_hemorrhage0.39788883
115MP0002009_preneoplasia0.39066263
116MP0000026_abnormal_inner_ear0.38303689
117MP0004185_abnormal_adipocyte_glucose0.38201324
118MP0000377_abnormal_hair_follicle0.38165882
119MP0000230_abnormal_systemic_arterial0.38143250
120MP0002060_abnormal_skin_morphology0.37936026
121MP0005379_endocrine/exocrine_gland_phen0.37815570
122MP0003795_abnormal_bone_structure0.37616904
123MP0002168_other_aberrant_phenotype0.37498113
124MP0005334_abnormal_fat_pad0.37295363
125MP0000371_diluted_coat_color0.37266946
126* MP0001731_abnormal_postnatal_growth0.36382040
127MP0000367_abnormal_coat/_hair0.36049694
128MP0003656_abnormal_erythrocyte_physiolo0.35783063
129MP0000432_abnormal_head_morphology0.34613113
130MP0008872_abnormal_physiological_respon0.34567153
131MP0003283_abnormal_digestive_organ0.34266490
132MP0005623_abnormal_meninges_morphology0.33870770
133MP0002932_abnormal_joint_morphology0.32773053
134MP0005386_behavior/neurological_phenoty0.32270994
135MP0004924_abnormal_behavior0.32270994
136MP0009333_abnormal_splenocyte_physiolog0.31936571
137MP0001348_abnormal_lacrimal_gland0.31572823
138MP0000647_abnormal_sebaceous_gland0.31465976
139MP0002133_abnormal_respiratory_system0.31012665
140MP0003329_amyloid_beta_deposits0.29791049
141MP0009642_abnormal_blood_homeostasis0.29163114
142MP0002069_abnormal_eating/drinking_beha0.29022566
143MP0002876_abnormal_thyroid_physiology0.28533969
144MP0000955_abnormal_spinal_cord0.27771007
145MP0010678_abnormal_skin_adnexa0.23309404
146MP0008469_abnormal_protein_level0.23207462
147MP0009703_decreased_birth_body0.22940024
148MP0002938_white_spotting0.21689339
149MP0005636_abnormal_mineral_homeostasis0.21586979
150* MP0003956_abnormal_body_size0.21376109
151MP0003763_abnormal_thymus_physiology0.20420156
152MP0000778_abnormal_nervous_system0.20375701
153MP0009780_abnormal_chondrocyte_physiolo0.19935048
154MP0005187_abnormal_penis_morphology0.19170513
155MP0003183_abnormal_peptide_metabolism0.18402752
156MP0003045_fibrosis0.17860879
157MP0003122_maternal_imprinting0.17844284
158MP0002896_abnormal_bone_mineralization0.17833617
159MP0009763_increased_sensitivity_to0.16685777

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.89361170
2Absent/shortened dynein arms (HP:0200106)9.25052139
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.25052139
4Steatorrhea (HP:0002570)9.04601035
5Abnormal ciliary motility (HP:0012262)8.67752072
6Abnormal respiratory motile cilium physiology (HP:0012261)8.61825422
7Abnormal respiratory motile cilium morphology (HP:0005938)8.35204797
8Abnormal respiratory epithelium morphology (HP:0012253)8.35204797
9Rhinitis (HP:0012384)7.60459514
10Fat malabsorption (HP:0002630)7.37745153
11Short chin (HP:0000331)6.78127769
12Decreased subcutaneous fat (HP:0001002)6.25484894
13Gout (HP:0001997)5.84971016
14Chronic bronchitis (HP:0004469)5.68600082
15Abnormality of subcutaneous fat tissue (HP:0001001)5.66757807
16Type I diabetes mellitus (HP:0100651)5.58898419
17Bronchiectasis (HP:0002110)5.49194676
18Exocrine pancreatic insufficiency (HP:0001738)5.10752177
19Maternal diabetes (HP:0009800)4.99802909
20Abnormality of the intrinsic pathway (HP:0010989)4.86529366
21Hypoplasia of the pons (HP:0012110)4.58294008
22Nasal polyposis (HP:0100582)4.45185707
23Abnormality of the pons (HP:0007361)4.32359016
24Abnormality of aromatic amino acid family metabolism (HP:0004338)4.10452647
25Pancreatitis (HP:0001733)4.04213241
26Hypoproteinemia (HP:0003075)4.00012857
27Joint stiffness (HP:0001387)3.93439545
28Cortical dysplasia (HP:0002539)3.92872438
29Premature skin wrinkling (HP:0100678)3.92561764
30Ketosis (HP:0001946)3.88281457
31Pancreatic fibrosis (HP:0100732)3.82739662
32Abnormality of the nasal mucosa (HP:0000433)3.72179626
33Abnormality of midbrain morphology (HP:0002418)3.71788633
34Molar tooth sign on MRI (HP:0002419)3.71788633
35True hermaphroditism (HP:0010459)3.69413389
36Tubulointerstitial nephritis (HP:0001970)3.66945083
37Pancreatic cysts (HP:0001737)3.60506124
38Ketoacidosis (HP:0001993)3.58203447
39Abnormal pancreas size (HP:0012094)3.51279165
40Carpal bone hypoplasia (HP:0001498)3.41692547
41Bronchitis (HP:0012387)3.39391081
42Chronic hepatic failure (HP:0100626)3.35170534
43Hyperglycinemia (HP:0002154)3.28846766
44Abnormality of the pancreatic islet cells (HP:0006476)3.20429063
45Abnormality of endocrine pancreas physiology (HP:0012093)3.20429063
46Long foot (HP:0001833)3.20116547
47Nephronophthisis (HP:0000090)3.18070086
48Cystic liver disease (HP:0006706)3.13658337
49Infertility (HP:0000789)3.13461648
50Male infertility (HP:0003251)3.13334846
51Abnormality of sulfur amino acid metabolism (HP:0004339)3.09655902
52Medial flaring of the eyebrow (HP:0010747)3.07531304
53Optic nerve hypoplasia (HP:0000609)3.06301395
54Abnormality of the common coagulation pathway (HP:0010990)2.99604572
55Tubulointerstitial fibrosis (HP:0005576)2.95863210
56Recurrent sinusitis (HP:0011108)2.95030975
57Chronic sinusitis (HP:0011109)2.93347798
58Abnormality of the renal medulla (HP:0100957)2.89159367
59Hyperglycinuria (HP:0003108)2.84617316
60Abnormal protein glycosylation (HP:0012346)2.82173314
61Abnormal glycosylation (HP:0012345)2.82173314
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.82173314
63Abnormal protein N-linked glycosylation (HP:0012347)2.82173314
64Prenatal maternal abnormality (HP:0002686)2.81100894
65Abnormality of serine family amino acid metabolism (HP:0010894)2.77934100
66Abnormality of glycine metabolism (HP:0010895)2.77934100
67Hypoglycemic coma (HP:0001325)2.71408134
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.64692463
69Fatigue (HP:0012378)2.62445362
70Increased purine levels (HP:0004368)2.61016562
71Hyperuricemia (HP:0002149)2.61016562
72Occipital encephalocele (HP:0002085)2.60468563
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59992740
74Congenital hepatic fibrosis (HP:0002612)2.58374670
75Progressive muscle weakness (HP:0003323)2.54677115
76Abnormal tarsal ossification (HP:0008369)2.54661706
77Recurrent otitis media (HP:0000403)2.54583217
78Abnormality of methionine metabolism (HP:0010901)2.50502643
79Pectus carinatum (HP:0000768)2.49938308
80Postaxial foot polydactyly (HP:0001830)2.40459323
81Stomach cancer (HP:0012126)2.39547990
82Reduced antithrombin III activity (HP:0001976)2.34398601
83Methylmalonic aciduria (HP:0012120)2.33392243
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28981848
85Small epiphyses (HP:0010585)2.28921943
86Hypoglycemic seizures (HP:0002173)2.28137969
87Hypoplasia of the odontoid process (HP:0003311)2.28041212
88Abnormality of homocysteine metabolism (HP:0010919)2.27990798
89Homocystinuria (HP:0002156)2.27990798
90Acute hepatic failure (HP:0006554)2.27170308
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.23041740
92Vacuolated lymphocytes (HP:0001922)2.22549542
93Opisthotonus (HP:0002179)2.22250767
94Concave nail (HP:0001598)2.21225488
95Tubular atrophy (HP:0000092)2.19171766
96Asplenia (HP:0001746)2.18274642
97Type II lissencephaly (HP:0007260)2.17413070
98Congenital glaucoma (HP:0001087)2.16972885
99Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15187862
100Myocardial infarction (HP:0001658)2.13076878
101Congenital primary aphakia (HP:0007707)2.08675399
102Large hands (HP:0001176)2.07765772
103Abnormal rod and cone electroretinograms (HP:0008323)2.07593472
104Chronic otitis media (HP:0000389)2.07485980
105Late onset (HP:0003584)2.06652520
106Gait imbalance (HP:0002141)2.05092046
107Barrel-shaped chest (HP:0001552)2.04771423
108Cortical visual impairment (HP:0100704)2.04006995
109Aplasia/Hypoplasia of the spleen (HP:0010451)2.02534363
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02236196
111Hyperphosphatemia (HP:0002905)2.01874060
112Acute encephalopathy (HP:0006846)1.99471049
113Anencephaly (HP:0002323)1.98574426
114Abnormal drinking behavior (HP:0030082)1.98071066
115Polydipsia (HP:0001959)1.98071066
116Dysostosis multiplex (HP:0000943)1.97094062
117Thoracic kyphosis (HP:0002942)1.96500122
118Hyperventilation (HP:0002883)1.95459724
119Infantile muscular hypotonia (HP:0008947)1.93894254
120Beaking of vertebral bodies (HP:0004568)1.93249377
121Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.92959675
122Oculomotor apraxia (HP:0000657)1.92755458
123Cerebral edema (HP:0002181)1.92654414
124Redundant skin (HP:0001582)1.91188586
125Ankyloglossia (HP:0010296)1.90219792
126Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88034262
127Dicarboxylic aciduria (HP:0003215)1.88034262
128Hyperammonemia (HP:0001987)1.87716906
129Hyperactive renin-angiotensin system (HP:0000841)1.84583085
130Abnormal foot bone ossification (HP:0010675)1.83743392
131Absent eyelashes (HP:0000561)1.83677181
132Cone-rod dystrophy (HP:0000548)1.83144074
133Furrowed tongue (HP:0000221)1.82682991
134Abnormality of the odontoid process (HP:0003310)1.82204376
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.82161201
136Recurrent bronchitis (HP:0002837)1.81809893
137Postaxial hand polydactyly (HP:0001162)1.81717008
138Male pseudohermaphroditism (HP:0000037)1.81643107
139Supernumerary spleens (HP:0009799)1.80868161
140Congenital, generalized hypertrichosis (HP:0004540)1.79787095
141Hyperinsulinemic hypoglycemia (HP:0000825)1.76951863
142Nephrogenic diabetes insipidus (HP:0009806)1.76239864
143Ventricular fibrillation (HP:0001663)1.74671405
144Coxa valga (HP:0002673)1.74256800
145Renal salt wasting (HP:0000127)1.74250314
146Esophageal varix (HP:0002040)1.74182155
147Lethargy (HP:0001254)1.73701974
148Abnormality of the thoracic spine (HP:0100711)1.73327043
149Type I transferrin isoform profile (HP:0003642)1.73240717
150Median cleft lip (HP:0000161)1.72852113
151Abnormality of the renal cortex (HP:0011035)1.72511797
152Decreased circulating renin level (HP:0003351)1.72396836
153Limb hypertonia (HP:0002509)1.71638531
154Athetosis (HP:0002305)1.71612723
155Vascular calcification (HP:0004934)1.68829909
156Tubulointerstitial abnormality (HP:0001969)1.68394200
157Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.68054432
158Hypokinesia (HP:0002375)1.67112074
159Abnormal hair whorl (HP:0010721)1.67012434
160Large for gestational age (HP:0001520)1.67009651
161Hypsarrhythmia (HP:0002521)1.66888418
162Abnormal biliary tract physiology (HP:0012439)1.66502530
163Bile duct proliferation (HP:0001408)1.66502530
164Abnormality of purine metabolism (HP:0004352)1.65070645
165Bony spicule pigmentary retinopathy (HP:0007737)1.63776972
166Constricted visual fields (HP:0001133)1.61461567
167Portal hypertension (HP:0001409)1.59646520
168Abnormality of the pleura (HP:0002103)1.59164499
169Sclerocornea (HP:0000647)1.54616193
170Vaginal atresia (HP:0000148)1.54599588
171Genital tract atresia (HP:0001827)1.54386028
172Poor coordination (HP:0002370)1.53498906
173Decreased central vision (HP:0007663)1.50057962
174Nephropathy (HP:0000112)1.48347983
175Anal atresia (HP:0002023)1.48226402
176Abolished electroretinogram (ERG) (HP:0000550)1.47099433
177Bell-shaped thorax (HP:0001591)1.46291197
178Azoospermia (HP:0000027)1.46192858
179Narrow forehead (HP:0000341)1.45547408
180Fibular hypoplasia (HP:0003038)1.44936414
181Abnormality of the hepatic vasculature (HP:0006707)1.42089354
182Abnormality of the middle phalanges of the toes (HP:0010183)1.41884188
183Gaze-evoked nystagmus (HP:0000640)1.41604933
184Volvulus (HP:0002580)1.37248636
185Polyuria (HP:0000103)1.31891905
186Hypoplastic labia majora (HP:0000059)1.31825464
187Disproportionate short-trunk short stature (HP:0003521)1.30146601
188Atelectasis (HP:0100750)1.28574273
189Abnormality of renal excretion (HP:0011036)1.28137870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.34318193
2MAP3K104.78470856
3EIF2AK34.52584015
4MAP2K24.26404480
5BMPR1B4.11937553
6PKN23.53191809
7TRIB33.46827282
8ACVR1B3.11448912
9MST42.47811245
10ERBB32.40544483
11MAP4K22.27930368
12FRK2.24988675
13TGFBR12.22002870
14EPHA22.21609887
15PNCK2.20683520
16LMTK22.17835812
17MAPKAPK32.14616871
18INSRR2.09877614
19BCKDK10.3725593
20TEC1.90642196
21ZAP701.89528446
22MAP2K11.75345393
23PAK21.73196016
24SCYL21.62256020
25GRK11.60065825
26IRAK31.58234158
27CDK81.56622705
28NME21.50929141
29NME11.42978683
30RPS6KB21.37984807
31DYRK1A1.37907206
32NLK1.37076661
33EEF2K1.34030829
34STK381.28843525
35TNIK1.28599529
36TRPM71.25060016
37TAOK31.21729579
38FLT31.20828268
39TAF11.20146644
40WNK41.20068336
41PIK3CG1.13836007
42BCR1.12126694
43ADRBK21.09376462
44PDGFRB1.06408838
45PIK3CA1.05894264
46PTK61.02515515
47SGK21.02107450
48CAMKK11.01927592
49HIPK21.00646602
50CASK0.99732972
51TLK10.94488017
52PTK2B0.93103259
53OXSR10.90402770
54LATS10.89701824
55PASK0.87984857
56SGK30.86998851
57MAPK150.86159335
58PDK20.84211735
59DAPK20.83446286
60BMPR20.83012940
61ITK0.83002914
62WEE10.75388067
63STK390.74700023
64MAP2K60.70206291
65EPHA30.69849179
66TIE10.69731011
67IRAK20.69378616
68MTOR0.66265814
69SIK10.65517790
70RET0.60818743
71MAPK120.59358046
72ADRBK10.58966520
73PRKCE0.58074524
74RPS6KB10.56615809
75NTRK30.56499437
76KIT0.56211429
77MAPK130.55470774
78SGK4940.55422223
79SGK2230.55422223
80CAMKK20.54653279
81BTK0.53962618
82PDPK10.52886204
83PRKCZ0.52844069
84LRRK20.52420749
85MAP3K20.52312217
86PRKCQ0.51552499
87MKNK10.50866892
88PLK20.50569457
89STK100.50305296
90NEK10.49181220
91IRAK40.48499426
92MKNK20.48214891
93WNK30.47690812
94CHUK0.47333764
95PDK10.47117962
96CDK60.46158384
97DYRK1B0.45297262
98CDK90.44997312
99PINK10.44515939
100PRKCI0.42758781
101MARK20.41617179
102STK240.40261738
103ILK0.39140153
104CDK30.38833258
105YES10.38466451
106BRSK20.37805763
107TSSK60.37166889
108PRKACB0.36904348
109NEK60.36493394
110PRKCH0.36128477
111PRKD20.35976348
112MAPK30.35525513
113MAP3K90.34771835
114MAPK70.32421003
115SGK10.32016737
116STK38L0.31978449
117MELK0.31344302
118PDK40.30056135
119PDK30.30056135
120NTRK10.29691458
121CDK190.27800813
122IKBKE0.27599459
123IKBKB0.27395828
124MAP3K70.27233258
125ROCK10.27181881
126DYRK20.27128112
127KSR20.27072236
128STK160.26616973
129PRKAA20.24685429
130FER0.23727794
131ABL10.22851724
132RPS6KA10.22643800
133DDR20.21844827
134TBK10.21638158
135HCK0.21365582
136MAPK110.21038660
137MET0.20714104
138JAK20.18640303
139MAP2K40.17968421
140UHMK10.17761317
141PDGFRA0.17171807
142MAP3K80.16434202
143MAPK10.16233689
144TYRO30.15996480
145MST1R0.15948237
146PIM20.14794562
147IRAK10.14454238
148IGF1R0.14381463
149MAP3K30.13667074
150CAMK1D0.13400646
151PRKD10.13194913
152AKT10.12828753
153CSNK1E0.09769655
154MAP3K10.09569755
155CSNK1G20.09188327
156RIPK10.09106379
157PTK20.08274895
158CSNK1G30.07826350
159EGFR0.07671914
160MATK0.07194400
161PRKACA0.06689722
162BRAF0.06355607
163CSNK1A1L0.06088053
164CSNK1A10.05561870
165RPS6KA30.04750488
166DAPK30.04433633
167MAP3K40.04170354
168EIF2AK10.03952211

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.42142285
2Fat digestion and absorption_Homo sapiens_hsa049756.00905232
3Protein digestion and absorption_Homo sapiens_hsa049745.60086673
4Protein export_Homo sapiens_hsa030603.46604632
5Glycerolipid metabolism_Homo sapiens_hsa005613.03186386
6Folate biosynthesis_Homo sapiens_hsa007903.01188585
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.88288785
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.83873105
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69995308
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25063605
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.19635464
12Propanoate metabolism_Homo sapiens_hsa006401.93023439
13Steroid biosynthesis_Homo sapiens_hsa001001.89230684
14Vitamin digestion and absorption_Homo sapiens_hsa049771.85365451
15Retinol metabolism_Homo sapiens_hsa008301.50760746
16Renin-angiotensin system_Homo sapiens_hsa046141.45074450
17Asthma_Homo sapiens_hsa053101.44707430
18Arginine and proline metabolism_Homo sapiens_hsa003301.28925445
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27176225
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19796628
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18523422
22Biosynthesis of amino acids_Homo sapiens_hsa012301.09081655
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06934291
24Linoleic acid metabolism_Homo sapiens_hsa005911.05215802
25N-Glycan biosynthesis_Homo sapiens_hsa005100.99166047
26Intestinal immune network for IgA production_Homo sapiens_hsa046720.90321592
27Cysteine and methionine metabolism_Homo sapiens_hsa002700.90197932
28Starch and sucrose metabolism_Homo sapiens_hsa005000.84154981
29Type I diabetes mellitus_Homo sapiens_hsa049400.83829109
30One carbon pool by folate_Homo sapiens_hsa006700.83701146
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83513904
32Other glycan degradation_Homo sapiens_hsa005110.80821398
33Selenocompound metabolism_Homo sapiens_hsa004500.80195147
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79323386
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78617894
36Steroid hormone biosynthesis_Homo sapiens_hsa001400.78574654
37Allograft rejection_Homo sapiens_hsa053300.76852226
38Notch signaling pathway_Homo sapiens_hsa043300.75682130
39Influenza A_Homo sapiens_hsa051640.75076722
40Autoimmune thyroid disease_Homo sapiens_hsa053200.74817750
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74810210
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73187528
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72167240
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71779169
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70642393
46beta-Alanine metabolism_Homo sapiens_hsa004100.68466219
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.68328221
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66215541
49Graft-versus-host disease_Homo sapiens_hsa053320.65553521
50ABC transporters_Homo sapiens_hsa020100.63363390
51Pyruvate metabolism_Homo sapiens_hsa006200.60095118
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59999950
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59523087
54Huntingtons disease_Homo sapiens_hsa050160.57952992
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55248131
56Staphylococcus aureus infection_Homo sapiens_hsa051500.55237737
57Fatty acid degradation_Homo sapiens_hsa000710.54627067
58Insulin secretion_Homo sapiens_hsa049110.53798133
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53062068
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52527704
61Vibrio cholerae infection_Homo sapiens_hsa051100.51744342
62Basal cell carcinoma_Homo sapiens_hsa052170.48485287
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48368672
64Sulfur metabolism_Homo sapiens_hsa009200.47464891
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47420262
66Circadian rhythm_Homo sapiens_hsa047100.46128529
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45102466
68Arginine biosynthesis_Homo sapiens_hsa002200.44394897
69Taste transduction_Homo sapiens_hsa047420.43601349
70Glutathione metabolism_Homo sapiens_hsa004800.41469853
71Salivary secretion_Homo sapiens_hsa049700.41246527
72Legionellosis_Homo sapiens_hsa051340.40965481
73Hedgehog signaling pathway_Homo sapiens_hsa043400.40340734
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.39310227
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38850518
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38789832
77Tyrosine metabolism_Homo sapiens_hsa003500.38712008
78Tryptophan metabolism_Homo sapiens_hsa003800.38694581
79Caffeine metabolism_Homo sapiens_hsa002320.37623908
80Arachidonic acid metabolism_Homo sapiens_hsa005900.37538505
81Carbon metabolism_Homo sapiens_hsa012000.36427274
82Rheumatoid arthritis_Homo sapiens_hsa053230.35844228
83Parkinsons disease_Homo sapiens_hsa050120.35404437
84Metabolic pathways_Homo sapiens_hsa011000.34519220
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34223661
86Fructose and mannose metabolism_Homo sapiens_hsa000510.34138899
87Sulfur relay system_Homo sapiens_hsa041220.33337427
88Phototransduction_Homo sapiens_hsa047440.30744930
89Alzheimers disease_Homo sapiens_hsa050100.30660299
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28872689
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28554503
92Tight junction_Homo sapiens_hsa045300.27285131
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26854707
94Olfactory transduction_Homo sapiens_hsa047400.25062944
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24521078
96Sphingolipid metabolism_Homo sapiens_hsa006000.24444985
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23481731
98Dorso-ventral axis formation_Homo sapiens_hsa043200.22720084
99Ether lipid metabolism_Homo sapiens_hsa005650.22344747
100Regulation of autophagy_Homo sapiens_hsa041400.20141945
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.19132801
102Endometrial cancer_Homo sapiens_hsa052130.19079462
103Calcium signaling pathway_Homo sapiens_hsa040200.18581273
104Hematopoietic cell lineage_Homo sapiens_hsa046400.18557437
105Lysosome_Homo sapiens_hsa041420.18324918
106Gastric acid secretion_Homo sapiens_hsa049710.18077000
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17525941
108Antigen processing and presentation_Homo sapiens_hsa046120.17132463
109Fatty acid metabolism_Homo sapiens_hsa012120.16663992
110Hippo signaling pathway_Homo sapiens_hsa043900.15782017
111VEGF signaling pathway_Homo sapiens_hsa043700.15625077
112Ribosome_Homo sapiens_hsa030100.13457252
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13266888
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12432242
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12388317
116Inositol phosphate metabolism_Homo sapiens_hsa005620.12154542
117Oxidative phosphorylation_Homo sapiens_hsa001900.12108004
118Nitrogen metabolism_Homo sapiens_hsa009100.11449274
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11121164
120Mineral absorption_Homo sapiens_hsa049780.10880634
121Peroxisome_Homo sapiens_hsa041460.10543675
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10376402
123cAMP signaling pathway_Homo sapiens_hsa040240.10175012
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.09932764
125Phenylalanine metabolism_Homo sapiens_hsa003600.09748799
126Leishmaniasis_Homo sapiens_hsa051400.09192806
127PPAR signaling pathway_Homo sapiens_hsa033200.08873902
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08401309
129Viral myocarditis_Homo sapiens_hsa054160.08326661
130Serotonergic synapse_Homo sapiens_hsa047260.08069173
131Histidine metabolism_Homo sapiens_hsa003400.07978210
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.04578704
133Chemical carcinogenesis_Homo sapiens_hsa052040.04213261
134Butanoate metabolism_Homo sapiens_hsa006500.03982883
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03630799
136Melanogenesis_Homo sapiens_hsa049160.03601483
137Prostate cancer_Homo sapiens_hsa052150.02377629
138mTOR signaling pathway_Homo sapiens_hsa041500.01957979
139Non-small cell lung cancer_Homo sapiens_hsa052230.00334211
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.00302790
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0569693
142Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0509508
143Insulin resistance_Homo sapiens_hsa04931-0.0315169
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010-0.0313511
145Toxoplasmosis_Homo sapiens_hsa05145-0.0284206
146Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0177688
147Bile secretion_Homo sapiens_hsa04976-0.0080004
148Galactose metabolism_Homo sapiens_hsa00052-0.0030351
149Drug metabolism - cytochrome P450_Homo sapiens_hsa00982-0.0021030

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