SERTAD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.73508064
2regulation of retinoic acid receptor signaling pathway (GO:0048385)4.92363795
3positive regulation of Cdc42 GTPase activity (GO:0043089)4.10491723
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.06086836
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90377988
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90377988
7neutrophil activation involved in immune response (GO:0002283)3.82801642
8antigen processing and presentation of endogenous antigen (GO:0019883)3.79612016
9positive regulation by symbiont of host defense response (GO:0052509)3.77251657
10modulation by symbiont of host defense response (GO:0052031)3.77251657
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.77251657
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.77251657
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.77251657
14modulation by symbiont of host immune response (GO:0052553)3.77251657
15COPI coating of Golgi vesicle (GO:0048205)3.71470572
16Golgi transport vesicle coating (GO:0048200)3.71470572
17regulation of RIG-I signaling pathway (GO:0039535)3.49910962
18ribosomal small subunit assembly (GO:0000028)3.43099530
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.39844613
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37596819
21nuclear envelope reassembly (GO:0031468)3.35876485
22mitotic nuclear envelope reassembly (GO:0007084)3.35876485
23protoporphyrinogen IX metabolic process (GO:0046501)3.28597565
24response to peptidoglycan (GO:0032494)3.22412026
25protein maturation by protein folding (GO:0022417)3.19832764
26protoporphyrinogen IX biosynthetic process (GO:0006782)3.17902429
27positive regulation of gamma-delta T cell activation (GO:0046645)3.17573978
28regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.13995676
29positive regulation of T cell apoptotic process (GO:0070234)3.11834322
30attachment of spindle microtubules to kinetochore (GO:0008608)3.09415410
31immunoglobulin mediated immune response (GO:0016064)3.02309188
32negative regulation of interleukin-12 production (GO:0032695)2.99626934
33type I interferon signaling pathway (GO:0060337)2.98648928
34cellular response to type I interferon (GO:0071357)2.98648928
35regulation of alpha-beta T cell proliferation (GO:0046640)2.98430253
36response to type I interferon (GO:0034340)2.97008909
37pentose-phosphate shunt (GO:0006098)2.93583929
38viral transcription (GO:0019083)2.92739527
39leukocyte aggregation (GO:0070486)2.92290515
40amino sugar catabolic process (GO:0046348)2.91517137
41positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89696660
42regulation of podosome assembly (GO:0071801)2.86987554
43positive regulation of interferon-alpha production (GO:0032727)2.84359196
44heme biosynthetic process (GO:0006783)2.82951729
45lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81855223
46cellular response to arsenic-containing substance (GO:0071243)2.80093614
47regulation of T-helper 2 cell differentiation (GO:0045628)2.79524647
48amyloid precursor protein catabolic process (GO:0042987)2.79236455
49ribosomal small subunit biogenesis (GO:0042274)2.79150874
50B cell mediated immunity (GO:0019724)2.76322421
51response to interferon-beta (GO:0035456)2.74993707
52NADPH regeneration (GO:0006740)2.74939975
53cellular response to interferon-beta (GO:0035458)2.74162397
54translational termination (GO:0006415)2.73693977
55regulation of vitamin D biosynthetic process (GO:0060556)2.71640116
56protein localization to endosome (GO:0036010)2.71522270
57pyrimidine-containing compound salvage (GO:0008655)2.67589819
58pyrimidine nucleoside salvage (GO:0043097)2.67589819
59macrophage activation involved in immune response (GO:0002281)2.67313022
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66378118
61cellular response to exogenous dsRNA (GO:0071360)2.65460290
62regulation of interferon-alpha production (GO:0032647)2.63167190
63cotranslational protein targeting to membrane (GO:0006613)2.61239662
64barbed-end actin filament capping (GO:0051016)2.61149841
65pinocytosis (GO:0006907)2.61121333
66Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60924321
67NIK/NF-kappaB signaling (GO:0038061)2.60634662
68glycosphingolipid catabolic process (GO:0046479)2.60479170
69cellular response to virus (GO:0098586)2.59485264
70protein targeting to ER (GO:0045047)2.59210858
71regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57311986
72endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.57065950
73positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56920471
74antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.55354254
75hepatocyte apoptotic process (GO:0097284)2.55041171
76regulation of mast cell degranulation (GO:0043304)2.54732959
77neutrophil activation (GO:0042119)2.53976976
78regulation of B cell receptor signaling pathway (GO:0050855)2.51598241
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51178711
80proteasome assembly (GO:0043248)2.50775644
81porphyrin-containing compound biosynthetic process (GO:0006779)2.50275465
82folic acid transport (GO:0015884)2.49732378
83regulation of type I interferon-mediated signaling pathway (GO:0060338)2.49284413
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.49183934
85positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.48254193
86mitotic metaphase plate congression (GO:0007080)2.47940036
87positive regulation of B cell differentiation (GO:0045579)2.47776367
88decidualization (GO:0046697)2.45802127
89positive regulation of T cell migration (GO:2000406)2.44603960
90sequestering of actin monomers (GO:0042989)2.44332495
91protein localization to endoplasmic reticulum (GO:0070972)2.44053629
92membrane protein intracellular domain proteolysis (GO:0031293)2.43834600
93positive regulation of lymphocyte apoptotic process (GO:0070230)2.41543453
94establishment of protein localization to endoplasmic reticulum (GO:0072599)2.40464700
95pyrimidine-containing compound transmembrane transport (GO:0072531)2.39802821
96translational elongation (GO:0006414)2.39174911
97heme metabolic process (GO:0042168)2.38888357
98regulation of cytokine secretion involved in immune response (GO:0002739)2.38813440
99negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.38342866
100negative regulation of myeloid cell apoptotic process (GO:0033033)2.36577735
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.36202643
102response to host immune response (GO:0052572)2.36202643
103telomere maintenance via semi-conservative replication (GO:0032201)2.35887787
104response to host (GO:0075136)2.35486452
105response to host defenses (GO:0052200)2.35486452
106response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.35486452
107glucose catabolic process (GO:0006007)2.35462467
108detection of other organism (GO:0098543)2.35085218
109T cell migration (GO:0072678)2.34819596
110protein localization to kinetochore (GO:0034501)2.34719057
111regulation of gamma-delta T cell differentiation (GO:0045586)2.34492479
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.33596448
113respiratory burst (GO:0045730)2.33587940
114positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32698135
115granulocyte activation (GO:0036230)2.32488136
116regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.32444457
117response to interferon-alpha (GO:0035455)2.31543591
118pentose metabolic process (GO:0019321)2.31266189
119oligosaccharide catabolic process (GO:0009313)2.30603195
120germinal center formation (GO:0002467)2.30506929
121interferon-gamma-mediated signaling pathway (GO:0060333)2.30017202
122protein localization to chromosome, centromeric region (GO:0071459)2.29740975
123establishment of chromosome localization (GO:0051303)2.29433085
124response to progesterone (GO:0032570)2.28784876
125leukocyte apoptotic process (GO:0071887)2.28770011
126regulation of T cell chemotaxis (GO:0010819)2.28663387
127positive regulation of T cell chemotaxis (GO:0010820)2.28663387
128telomere maintenance via recombination (GO:0000722)2.28655209
129meiotic chromosome segregation (GO:0045132)2.27665769
130regulation of T cell migration (GO:2000404)2.27046970
131regulation of B cell differentiation (GO:0045577)2.26993193
132regulation of response to interferon-gamma (GO:0060330)2.26842697
133regulation of T-helper 1 cell differentiation (GO:0045625)2.26445418
134positive regulation of interferon-beta production (GO:0032728)2.26396234
135negative thymic T cell selection (GO:0045060)2.25572116
136positive regulation of isotype switching (GO:0045830)2.25380554
137response to laminar fluid shear stress (GO:0034616)2.24954869
138negative T cell selection (GO:0043383)2.24899440
139regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24839309
140regulation of mast cell activation involved in immune response (GO:0033006)2.24710633
141regulation of leukocyte degranulation (GO:0043300)2.23439349
142positive thymic T cell selection (GO:0045059)2.23098629
143antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.23036903
144glycolipid catabolic process (GO:0019377)2.23022835
145regulation of gamma-delta T cell activation (GO:0046643)2.22819087
146stress fiber assembly (GO:0043149)2.21482930
147response to muramyl dipeptide (GO:0032495)2.20745244
148epithelial cell differentiation involved in prostate gland development (GO:0060742)2.20569643
149activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.20051792
150detection of bacterium (GO:0016045)2.19501247
151hyaluronan catabolic process (GO:0030214)2.19396596
152translational initiation (GO:0006413)2.18873486
153branching involved in labyrinthine layer morphogenesis (GO:0060670)2.18650612
154modulation by symbiont of host cellular process (GO:0044068)2.18426710
155detection of molecule of bacterial origin (GO:0032490)2.17698506
156virion assembly (GO:0019068)2.17320153
157positive regulation of protein homooligomerization (GO:0032464)2.17164893
158interferon-gamma secretion (GO:0072643)2.16995994
159negative regulation of viral genome replication (GO:0045071)2.16482196
160regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.16058828
161viral life cycle (GO:0019058)2.15525074
162regulation of necroptotic process (GO:0060544)2.15101248
163negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.14514081
164GDP-mannose metabolic process (GO:0019673)2.14246985
165regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.14038261
166virion attachment to host cell (GO:0019062)2.13371199
167adhesion of symbiont to host cell (GO:0044650)2.13371199
168positive regulation of monocyte chemotaxis (GO:0090026)2.13074957
169negative regulation of cytokine production involved in immune response (GO:0002719)2.12926529
170maturation of SSU-rRNA (GO:0030490)2.12436967
171regulation of interferon-beta biosynthetic process (GO:0045357)2.11836612
172DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.11721512
173cellular response to thyroid hormone stimulus (GO:0097067)2.11622535
174regulation of interleukin-8 biosynthetic process (GO:0045414)2.11235148
175tetrapyrrole biosynthetic process (GO:0033014)2.11068999
176cellular response to zinc ion (GO:0071294)2.10154267
177nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.10105437
178myeloid dendritic cell activation (GO:0001773)2.10067758
179porphyrin-containing compound metabolic process (GO:0006778)2.08791260
180mitotic chromosome condensation (GO:0007076)2.08768310
181regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.08291962
182DNA strand elongation involved in DNA replication (GO:0006271)2.07318024
183metaphase plate congression (GO:0051310)2.07042204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.19493362
2E2F7_22180533_ChIP-Seq_HELA_Human4.19416514
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14159536
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.10495413
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98646763
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91111613
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.90843719
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68557583
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45844484
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30366962
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28579262
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17680648
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14673766
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11716035
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07768137
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.07365608
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.06248705
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.00890528
19STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99238356
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90939609
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90788835
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86990039
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86718758
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85770178
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.83764711
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.83701081
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81942247
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79519484
29SCL_19346495_ChIP-Seq_HPC-7_Human1.77982457
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77704299
31ZNF263_19887448_ChIP-Seq_K562_Human1.75877730
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75446548
33* RACK7_27058665_Chip-Seq_MCF-7_Human1.74940737
34SPI1_23547873_ChIP-Seq_NB4_Human1.73051877
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70555676
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.70418948
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.67840395
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.67465252
39VDR_23849224_ChIP-Seq_CD4+_Human1.64613408
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64385617
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63425965
42MYB_26560356_Chip-Seq_TH2_Human1.60729673
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.60205540
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59175698
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58598526
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58248796
47* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58201033
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57022390
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56726817
50VDR_21846776_ChIP-Seq_THP-1_Human1.54850496
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52016894
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51767774
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50175386
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49817285
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.49624289
56LXR_22292898_ChIP-Seq_THP-1_Human1.49339110
57MYC_22102868_ChIP-Seq_BL_Human1.49213962
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46427610
59ELK1_19687146_ChIP-ChIP_HELA_Human1.46391531
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.45919852
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45738057
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44509608
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44080890
64XRN2_22483619_ChIP-Seq_HELA_Human1.43951271
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43701054
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43248280
67* MAF_26560356_Chip-Seq_TH1_Human1.42165578
68GATA1_22025678_ChIP-Seq_K562_Human1.40071414
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38899580
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38852266
71* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38285824
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38265068
73* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38146720
74MYB_26560356_Chip-Seq_TH1_Human1.36230675
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36090796
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34293750
77FOXP3_21729870_ChIP-Seq_TREG_Human1.34273729
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.34273060
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34185351
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33964908
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33852386
82* UTX_26944678_Chip-Seq_JUKART_Human1.31108429
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.30993677
84ATF3_27146783_Chip-Seq_COLON_Human1.30711638
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30514758
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30445699
87VDR_24763502_ChIP-Seq_THP-1_Human1.28304925
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27880243
89DCP1A_22483619_ChIP-Seq_HELA_Human1.27839345
90* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25247246
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.23966450
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23644037
93* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19968570
94CLOCK_20551151_ChIP-Seq_293T_Human1.19501020
95* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18881864
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18745081
97* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18499538
98* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18336614
99TCF7_22412390_ChIP-Seq_EML_Mouse1.17401885
100* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16677729
101* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16496430
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14289629
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13757161
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13757161
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13757161
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13664164
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13618899
108NCOR1_26117541_ChIP-Seq_K562_Human1.10996624
109MAF_26560356_Chip-Seq_TH2_Human1.10935500
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10674204
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10205657
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07280576
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07262946
114* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06614321
115GABP_19822575_ChIP-Seq_HepG2_Human1.06454643
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05988072
117BCOR_27268052_Chip-Seq_Bcells_Human1.05763657
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05249535
119KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04641260
120* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03857804
121* KDM2B_26808549_Chip-Seq_DND41_Human1.03397947
122FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02630402
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00412839
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00074704
125AR_21909140_ChIP-Seq_LNCAP_Human0.99537569
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98487931
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.97841319
128NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97298319
129E2F1_21310950_ChIP-Seq_MCF-7_Human0.97001488
130TFEB_21752829_ChIP-Seq_HELA_Human0.96955683
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96768832
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96127841
133CIITA_25753668_ChIP-Seq_RAJI_Human0.96085977
134* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95238247
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93343836
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93341176
137RUNX_20019798_ChIP-Seq_JUKART_Human0.91862884
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90520489
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90490827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.19243805
2MP0009785_altered_susceptibility_to2.92686700
3MP0008260_abnormal_autophagy2.87541951
4MP0003436_decreased_susceptibility_to2.72942469
5MP0000685_abnormal_immune_system2.70354334
6MP0005671_abnormal_response_to2.52046509
7MP0003191_abnormal_cellular_cholesterol2.50442401
8MP0005025_abnormal_response_to2.29721360
9MP0005000_abnormal_immune_tolerance2.24092398
10MP0003693_abnormal_embryo_hatching2.23085851
11MP0003763_abnormal_thymus_physiology2.21049662
12MP0002148_abnormal_hypersensitivity_rea2.19239481
13MP0004510_myositis2.14124930
14MP0006082_CNS_inflammation2.12498582
15MP0001790_abnormal_immune_system2.09646029
16MP0005387_immune_system_phenotype2.09646029
17MP0001800_abnormal_humoral_immune2.05552009
18MP0009333_abnormal_splenocyte_physiolog2.00051538
19MP0002419_abnormal_innate_immunity1.96394676
20MP0002452_abnormal_antigen_presenting1.96099702
21MP0002405_respiratory_system_inflammati1.94108858
22MP0003656_abnormal_erythrocyte_physiolo1.92079213
23MP0002723_abnormal_immune_serum1.86492102
24MP0001819_abnormal_immune_cell1.86330213
25MP0002420_abnormal_adaptive_immunity1.85713191
26MP0003724_increased_susceptibility_to1.85412047
27MP0002254_reproductive_system_inflammat1.84868496
28MP0008438_abnormal_cutaneous_collagen1.84449345
29MP0000750_abnormal_muscle_regeneration1.84397055
30MP0003077_abnormal_cell_cycle1.81383591
31MP0003828_pulmonary_edema1.79690435
32MP0002877_abnormal_melanocyte_morpholog1.79242185
33MP0002398_abnormal_bone_marrow1.78834502
34MP0003186_abnormal_redox_activity1.77285343
35MP0001545_abnormal_hematopoietic_system1.73013661
36MP0005397_hematopoietic_system_phenotyp1.73013661
37MP0002166_altered_tumor_susceptibility1.66319312
38MP0004957_abnormal_blastocyst_morpholog1.65660042
39MP0000858_altered_metastatic_potential1.65573538
40MP0002132_abnormal_respiratory_system1.63757811
41MP0000716_abnormal_immune_system1.60247683
42MP0002006_tumorigenesis1.58227430
43MP0010234_abnormal_vibrissa_follicle1.57720412
44MP0001542_abnormal_bone_strength1.54637750
45MP0004947_skin_inflammation1.54016678
46MP0003111_abnormal_nucleus_morphology1.52527981
47MP0003075_altered_response_to1.52131491
48MP0002722_abnormal_immune_system1.52047517
49MP0000689_abnormal_spleen_morphology1.51632808
50MP0004264_abnormal_extraembryonic_tissu1.51190618
51MP0001853_heart_inflammation1.46360736
52MP0000465_gastrointestinal_hemorrhage1.45646536
53MP0002396_abnormal_hematopoietic_system1.45548738
54MP0002429_abnormal_blood_cell1.44687841
55MP0001533_abnormal_skeleton_physiology1.43916958
56MP0005464_abnormal_platelet_physiology1.41372819
57MP0001346_abnormal_lacrimal_gland1.40470858
58MP0010155_abnormal_intestine_physiology1.40215725
59MP0004233_abnormal_muscle_weight1.39996110
60MP0002796_impaired_skin_barrier1.38945211
61MP0008004_abnormal_stomach_pH1.35649749
62MP0001845_abnormal_inflammatory_respons1.35006964
63MP0010094_abnormal_chromosome_stability1.34357564
64MP0008007_abnormal_cellular_replicative1.34210223
65MP0000490_abnormal_crypts_of1.33319665
66MP0000343_altered_response_to1.31620746
67MP0009278_abnormal_bone_marrow1.30971226
68MP0000703_abnormal_thymus_morphology1.28570613
69MP0002019_abnormal_tumor_incidence1.27911340
70MP0009053_abnormal_anal_canal1.27786434
71MP0003453_abnormal_keratinocyte_physiol1.26591429
72MP0005257_abnormal_intraocular_pressure1.26418983
73MP0009840_abnormal_foam_cell1.25274086
74MP0003448_altered_tumor_morphology1.25223992
75MP0005451_abnormal_body_composition1.24560093
76MP0003172_abnormal_lysosome_physiology1.19656358
77MP0010352_gastrointestinal_tract_polyps1.19211917
78MP0003091_abnormal_cell_migration1.19204835
79MP0005408_hypopigmentation1.17871476
80MP0003279_aneurysm1.17058331
81MP0006054_spinal_hemorrhage1.17029246
82MP0004808_abnormal_hematopoietic_stem1.16626011
83MP0008469_abnormal_protein_level1.09233249
84MP0000516_abnormal_urinary_system1.07918592
85MP0005367_renal/urinary_system_phenotyp1.07918592
86MP0002332_abnormal_exercise_endurance1.07167741
87MP0008058_abnormal_DNA_repair1.06758930
88MP0000767_abnormal_smooth_muscle1.06526764
89MP0003221_abnormal_cardiomyocyte_apopto1.05520286
90MP0008057_abnormal_DNA_replication1.04694873
91MP0005076_abnormal_cell_differentiation1.03944723
92MP0005310_abnormal_salivary_gland1.02445141
93MP0009764_decreased_sensitivity_to1.01719704
94MP0003806_abnormal_nucleotide_metabolis1.01411927
95MP0005164_abnormal_response_to1.00696480
96MP0003718_maternal_effect0.99746625
97MP0005023_abnormal_wound_healing0.99084861
98MP0004147_increased_porphyrin_level0.97036937
99MP0001849_ear_inflammation0.96420531
100MP0010307_abnormal_tumor_latency0.96344607
101MP0003566_abnormal_cell_adhesion0.96155014
102MP0002933_joint_inflammation0.95525132
103MP0005501_abnormal_skin_physiology0.94342695
104MP0005166_decreased_susceptibility_to0.93169923
105MP0004272_abnormal_basement_membrane0.90452372
106MP0000313_abnormal_cell_death0.89693025
107MP0003303_peritoneal_inflammation0.89683191
108MP0005390_skeleton_phenotype0.86802064
109MP0002277_abnormal_respiratory_mucosa0.86567344
110MP0000350_abnormal_cell_proliferation0.85387289
111MP0009763_increased_sensitivity_to0.83418184
112MP0005165_increased_susceptibility_to0.82434443
113MP0000566_synostosis0.82332733
114MP0003795_abnormal_bone_structure0.81956192
115MP0005330_cardiomyopathy0.81437156
116MP0001727_abnormal_embryo_implantation0.80164852
117MP0000749_muscle_degeneration0.80141695
118MP0005410_abnormal_fertilization0.78969677
119MP0002060_abnormal_skin_morphology0.78910537
120MP0005058_abnormal_lysosome_morphology0.77222126
121MP0003183_abnormal_peptide_metabolism0.76667573
122MP0000747_muscle_weakness0.74403528
123MP0002282_abnormal_trachea_morphology0.72907233
124MP0004858_abnormal_nervous_system0.72743910
125MP0000358_abnormal_cell_content/0.71012911
126MP0005319_abnormal_enzyme/_coenzyme0.70364659
127MP0003300_gastrointestinal_ulcer0.69871635
128MP0002098_abnormal_vibrissa_morphology0.69732400
129MP0003705_abnormal_hypodermis_morpholog0.69516255
130MP0001191_abnormal_skin_condition0.69142517
131MP0001216_abnormal_epidermal_layer0.68700842
132MP0001915_intracranial_hemorrhage0.68059105
133MP0010030_abnormal_orbit_morphology0.67973083
134MP0001119_abnormal_female_reproductive0.67935190
135MP0005083_abnormal_biliary_tract0.67793690
136MP0009384_cardiac_valve_regurgitation0.66600574
137MP0002998_abnormal_bone_remodeling0.66575360
138MP0008932_abnormal_embryonic_tissue0.66326550
139MP0003943_abnormal_hepatobiliary_system0.63918791
140MP0003786_premature_aging0.63701652
141MP0000477_abnormal_intestine_morphology0.62147784

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.81722232
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.81722232
3Abnormality of glycolipid metabolism (HP:0010969)4.81722232
4Vacuolated lymphocytes (HP:0001922)4.27099472
5Eczematoid dermatitis (HP:0000976)3.93853224
6Elevated erythrocyte sedimentation rate (HP:0003565)3.92867855
7Recurrent abscess formation (HP:0002722)3.80642703
8Axonal loss (HP:0003447)3.73945873
9Chronic otitis media (HP:0000389)3.46682315
10Loss of speech (HP:0002371)3.37401895
11Abnormal gallbladder physiology (HP:0012438)3.29517508
12Cholecystitis (HP:0001082)3.29517508
13Distal lower limb muscle weakness (HP:0009053)3.28928773
14Mediastinal lymphadenopathy (HP:0100721)3.27213913
15Chronic mucocutaneous candidiasis (HP:0002728)3.24417200
16Recurrent cutaneous fungal infections (HP:0011370)3.24417200
17Abnormality of T cell number (HP:0011839)3.24282487
18Recurrent fungal infections (HP:0002841)3.21339851
19Recurrent viral infections (HP:0004429)3.20585656
20Recurrent bacterial skin infections (HP:0005406)3.20260884
21Combined immunodeficiency (HP:0005387)3.12166592
22T lymphocytopenia (HP:0005403)3.11118534
23Premature rupture of membranes (HP:0001788)3.09329340
24Increased IgM level (HP:0003496)3.09275627
25Dysostosis multiplex (HP:0000943)3.06783240
26Myositis (HP:0100614)3.03533817
27Autoimmune thrombocytopenia (HP:0001973)2.99693106
28Increased cerebral lipofuscin (HP:0011813)2.91097165
29Severe combined immunodeficiency (HP:0004430)2.88025191
30Reticulocytopenia (HP:0001896)2.83265505
31Recurrent skin infections (HP:0001581)2.82074631
32Petechiae (HP:0000967)2.78955087
33Granulocytopenia (HP:0001913)2.78392810
34Rough bone trabeculation (HP:0100670)2.77844989
35Abnormality of eosinophils (HP:0001879)2.74906143
36Abnormality of T cells (HP:0002843)2.70005697
37Eosinophilia (HP:0001880)2.69239966
38Prolonged neonatal jaundice (HP:0006579)2.68801661
39Abnormality of macrophages (HP:0004311)2.68647568
40Panhypogammaglobulinemia (HP:0003139)2.66181725
41Nasal polyposis (HP:0100582)2.65821287
42Leukocytosis (HP:0001974)2.65466338
43Systemic lupus erythematosus (HP:0002725)2.65359826
44Malnutrition (HP:0004395)2.65109128
45Recurrent bronchitis (HP:0002837)2.64189348
46Myocardial infarction (HP:0001658)2.63249102
47Nuclear cataract (HP:0100018)2.59117100
48Recurrent gram-negative bacterial infections (HP:0005420)2.54683908
49Pustule (HP:0200039)2.54196304
50IgG deficiency (HP:0004315)2.53480484
51Stomatitis (HP:0010280)2.50883246
52Increased serum ferritin (HP:0003281)2.50513916
53Thrombocytosis (HP:0001894)2.49528328
54Abnormality of cells of the erythroid lineage (HP:0012130)2.47884169
55Abnormality of T cell physiology (HP:0011840)2.44124735
56Abnormal number of erythroid precursors (HP:0012131)2.43611266
57Orchitis (HP:0100796)2.40397492
58Abnormal trabecular bone morphology (HP:0100671)2.39629597
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.38112783
60Increased connective tissue (HP:0009025)2.37431911
61Diaphragmatic weakness (HP:0009113)2.37030529
62Abnormality of polysaccharide metabolism (HP:0011012)2.36740611
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36740611
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36740611
65Abnormality of the fetal cardiovascular system (HP:0010948)2.35716083
66Abnormal umbilical cord blood vessels (HP:0011403)2.35716083
67Single umbilical artery (HP:0001195)2.35716083
68Abnormality of the nasal mucosa (HP:0000433)2.35290330
69Cervical subluxation (HP:0003308)2.33567788
70Abnormality of the distal phalanges of the toes (HP:0010182)2.32071846
71Abnormality of the umbilical cord (HP:0010881)2.31704883
72J-shaped sella turcica (HP:0002680)2.27788569
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25151423
74Meningitis (HP:0001287)2.24667320
75Thyroiditis (HP:0100646)2.24325501
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.24215858
77Cellulitis (HP:0100658)2.23607440
78Amyloidosis (HP:0011034)2.22265142
79Poikilocytosis (HP:0004447)2.21890234
80Hypoplasia of the thymus (HP:0000778)2.21416687
81Urinary glycosaminoglycan excretion (HP:0003541)2.19077946
82Mucopolysacchariduria (HP:0008155)2.19077946
83IgM deficiency (HP:0002850)2.18497245
84Progressive neurologic deterioration (HP:0002344)2.14866254
85Agammaglobulinemia (HP:0004432)2.14654538
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.14015235
87Cleft eyelid (HP:0000625)2.13404433
88Generalized amyotrophy (HP:0003700)2.12729481
89Interstitial pulmonary disease (HP:0006530)2.10972287
90Abnormality of the prostate (HP:0008775)2.10186791
91Aplastic anemia (HP:0001915)2.09092266
92Nausea (HP:0002018)2.07839271
93Vertebral compression fractures (HP:0002953)2.07795465
94Urticaria (HP:0001025)2.07178610
95Poor head control (HP:0002421)2.06451127
96Popliteal pterygium (HP:0009756)2.05953015
97Retrobulbar optic neuritis (HP:0100654)2.05271212
98Optic neuritis (HP:0100653)2.05271212
99Hepatosplenomegaly (HP:0001433)2.03726147
100Muscle fiber atrophy (HP:0100295)2.03044160
101Ragged-red muscle fibers (HP:0003200)2.02863243
102Vasculitis (HP:0002633)2.01811353
103Micronodular cirrhosis (HP:0001413)1.99693057
104Bulbar palsy (HP:0001283)1.99276704
105Trismus (HP:0000211)1.98506952
106Microcytic anemia (HP:0001935)1.97785632
107IgA deficiency (HP:0002720)1.96816749
108Fatigue (HP:0012378)1.95367446
109Carpal bone hypoplasia (HP:0001498)1.93879048
110Mutism (HP:0002300)1.92333450
111Asymmetric septal hypertrophy (HP:0001670)1.92264735
112Spontaneous hematomas (HP:0007420)1.92053460
113Lymphoma (HP:0002665)1.92020229
114Hypertensive crisis (HP:0100735)1.91631934
115Centrally nucleated skeletal muscle fibers (HP:0003687)1.90480483
116Hypergammaglobulinemia (HP:0010702)1.90252669
117Hemoptysis (HP:0002105)1.89438345
118Basal ganglia calcification (HP:0002135)1.88731059
119Hematochezia (HP:0002573)1.88447308
120Erythema (HP:0010783)1.88123713
121Purpura (HP:0000979)1.87694951
122Prostate neoplasm (HP:0100787)1.87224458
123Type 2 muscle fiber atrophy (HP:0003554)1.86207378
124Abnormality of transition element cation homeostasis (HP:0011030)1.85475373
125Colon cancer (HP:0003003)1.85038403
126Osteolytic defects of the hand bones (HP:0009699)1.84549161
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.84549161
128Deformed sella turcica (HP:0002681)1.84434298
129Upper limb amyotrophy (HP:0009129)1.83595142
130Distal upper limb amyotrophy (HP:0007149)1.83595142
131Progressive muscle weakness (HP:0003323)1.83418326
132Abnormalities of placenta or umbilical cord (HP:0001194)1.83065579
133Autoimmune hemolytic anemia (HP:0001890)1.82386463
134Chronic obstructive pulmonary disease (HP:0006510)1.81035702
135Obstructive lung disease (HP:0006536)1.81035702
136Gingivitis (HP:0000230)1.79894498
137Difficulty climbing stairs (HP:0003551)1.79417021
138Exertional dyspnea (HP:0002875)1.79228470
139Cheilitis (HP:0100825)1.78001963
140Hypochromic anemia (HP:0001931)1.76652700
141Distal lower limb amyotrophy (HP:0008944)1.75481534
142Abnormality of reticulocytes (HP:0004312)1.74493496
143Short nail (HP:0001799)1.74336706
144Skin ulcer (HP:0200042)1.74276957
145Encephalitis (HP:0002383)1.73977465
146Keratoconjunctivitis sicca (HP:0001097)1.73909657
147Pallor (HP:0000980)1.73828119
148Cutaneous photosensitivity (HP:0000992)1.73578147
149Nonimmune hydrops fetalis (HP:0001790)1.72941636
150Macrocytic anemia (HP:0001972)1.72565583
151Reduced antithrombin III activity (HP:0001976)1.72525847
152Muscle fibrillation (HP:0010546)1.72508911
153Recurrent lower respiratory tract infections (HP:0002783)1.72077382
154Small epiphyses (HP:0010585)1.71828347
155Upper motor neuron abnormality (HP:0002127)1.71727447
156Hand muscle atrophy (HP:0009130)1.70906029
157Neutropenia (HP:0001875)1.70805522
158Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69578083
159Parakeratosis (HP:0001036)1.68557644
160Breast hypoplasia (HP:0003187)1.68059953
161Skin rash (HP:0000988)1.67780023
162Recurrent pneumonia (HP:0006532)1.67255487
163Osteomyelitis (HP:0002754)1.66665802
164Disinhibition (HP:0000734)1.66386356
165Bone pain (HP:0002653)1.65647529
166Dilatation of the ascending aorta (HP:0005111)1.65239498
167Abnormality of iron homeostasis (HP:0011031)1.64784388
168Hypokinesia (HP:0002375)1.64497856
169Ankle contracture (HP:0006466)1.63436292
170Achilles tendon contracture (HP:0001771)1.63375496
171Reduced subcutaneous adipose tissue (HP:0003758)1.61223373
172Myopathic facies (HP:0002058)1.60543613
173Fasciculations (HP:0002380)1.59912696
174Spinal rigidity (HP:0003306)1.58503097
175Shoulder girdle muscle weakness (HP:0003547)1.57052478
176Degeneration of anterior horn cells (HP:0002398)1.55134095
177Abnormality of the anterior horn cell (HP:0006802)1.55134095
178Protrusio acetabuli (HP:0003179)1.55132367
179Hypoplastic left heart (HP:0004383)1.55002807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K33.40989604
2EPHA22.61905682
3TRIB32.43371356
4IRAK42.31209338
5PIM22.29982846
6MAP4K12.25002322
7TYK22.24700014
8VRK22.20419131
9TAOK22.17708120
10JAK32.13026832
11MAP3K142.07402324
12PRPF4B2.02725013
13IKBKE2.02112826
14TLK12.00414288
15STK101.94630526
16TBK11.92846731
17KIT1.87841880
18BUB11.87202203
19CLK11.85452407
20TESK21.84667411
21SIK11.83112740
22NLK1.82197608
23NME21.75180823
24STK41.73263284
25BLK1.70391817
26SIK31.69901451
27PBK1.67807500
28FGFR41.64436811
29ERN11.60955554
30IKBKB1.59919753
31EIF2AK11.55786002
32IRAK31.55038610
33SMG11.48879271
34PIM11.47210688
35TXK1.45611331
36MST41.44841076
37TAOK11.43837095
38EPHB11.40240073
39BTK1.36046228
40MAP3K101.34940553
41TAOK31.31298673
42RPS6KA41.26315269
43VRK11.25863884
44MELK1.25573299
45PDK21.25453316
46KDR1.24430503
47DDR21.22182852
48CHUK1.20611727
49LIMK11.15984912
50MAP3K21.14379982
51TEC1.13081962
52MAPK111.11182046
53NEK91.08507191
54CSK1.06473521
55RPS6KA51.06345408
56TRPM71.05121550
57STK161.03891146
58RPS6KB21.03258649
59MYLK1.02297068
60JAK11.00848154
61MAP3K121.00095400
62LRRK20.98519894
63MATK0.98393002
64ZAK0.98172858
65MAP3K80.96526314
66ITK0.96185326
67MAP3K10.95675490
68TTK0.95489124
69ILK0.95105672
70NEK20.92562893
71TGFBR20.91164223
72KSR20.91071226
73FRK0.90227346
74ZAP700.89345650
75MAP3K110.89235361
76MAP2K30.88238562
77BMPR20.86174998
78PASK0.84237185
79FGR0.82874508
80GRK60.80328905
81FGFR30.80316355
82PLK10.79754577
83MARK30.79536478
84ABL20.79462594
85LYN0.79165168
86CDK60.78297411
87LCK0.75941160
88SYK0.75547841
89AURKB0.75461439
90BMX0.74749154
91PKN20.74555742
92TTN0.74089381
93TESK10.73360334
94WEE10.73211772
95CDK40.73118295
96RIPK40.72910870
97LATS20.72413876
98GRK70.71716005
99DYRK30.70523244
100IRAK20.66450500
101PLK40.66265389
102ERBB40.65404609
103EIF2AK30.64250582
104CDC70.62444371
105MAPKAPK20.61936808
106ARAF0.61233672
107EPHA30.60103368
108MAP3K50.60004002
109PAK40.59287650
110JAK20.59184257
111PDPK10.58899417
112CDK70.58871120
113ATR0.58562768
114MST1R0.58521668
115CSF1R0.58195701
116SRPK10.57868609
117BRSK20.57340043
118PAK10.57185170
119MAPKAPK30.56891979
120IRAK10.55902362
121STK240.55766177
122DYRK1B0.55431864
123PRKD20.55210343
124SCYL20.54959898
125BCKDK0.54319094
126PRKG20.54159444
127PRKCI0.54081056
128EPHB20.53644199
129MAP2K20.52569753
130RIPK10.52478068
131FLT30.50740894
132MAP3K130.50511416
133PTK60.50502132
134PTK20.50039427
135BRSK10.49813606
136TRIM280.49279250
137DAPK30.47853285
138STK30.47662519
139BRAF0.47174236
140CDK80.47172822
141YES10.46645774
142RAF10.44544039
143CDK90.43880038
144ACVR1B0.43590675
145NEK60.43489233
146MOS0.41623448
147CDC42BPA0.40599861
148RPS6KC10.38899800
149RPS6KL10.38899800
150LMTK20.37873840
151MAPK150.37872513

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.53225661
2Primary immunodeficiency_Homo sapiens_hsa053402.50708600
3DNA replication_Homo sapiens_hsa030302.47832674
4Proteasome_Homo sapiens_hsa030502.47109383
5Graft-versus-host disease_Homo sapiens_hsa053322.25694294
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24555239
7Mismatch repair_Homo sapiens_hsa034301.98245445
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94086961
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.92838010
10Antigen processing and presentation_Homo sapiens_hsa046121.92041353
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.86485005
12Galactose metabolism_Homo sapiens_hsa000521.73343480
13Malaria_Homo sapiens_hsa051441.72515767
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71181005
15Base excision repair_Homo sapiens_hsa034101.67640504
16Herpes simplex infection_Homo sapiens_hsa051681.65620912
17Allograft rejection_Homo sapiens_hsa053301.65545791
18Cell cycle_Homo sapiens_hsa041101.65379923
19Leishmaniasis_Homo sapiens_hsa051401.64063911
20Homologous recombination_Homo sapiens_hsa034401.63692800
21Non-homologous end-joining_Homo sapiens_hsa034501.61191823
22Measles_Homo sapiens_hsa051621.60599519
23RNA polymerase_Homo sapiens_hsa030201.57267542
24Protein export_Homo sapiens_hsa030601.50127300
25Acute myeloid leukemia_Homo sapiens_hsa052211.46853088
26Nucleotide excision repair_Homo sapiens_hsa034201.45772614
27Fructose and mannose metabolism_Homo sapiens_hsa000511.42336677
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41621509
29Vibrio cholerae infection_Homo sapiens_hsa051101.36993362
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35510870
31Folate biosynthesis_Homo sapiens_hsa007901.34991904
32Pyrimidine metabolism_Homo sapiens_hsa002401.34150931
33Systemic lupus erythematosus_Homo sapiens_hsa053221.34125632
34Legionellosis_Homo sapiens_hsa051341.33655153
35Hematopoietic cell lineage_Homo sapiens_hsa046401.33353462
36Basal transcription factors_Homo sapiens_hsa030221.32986843
37Staphylococcus aureus infection_Homo sapiens_hsa051501.32013365
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28881843
39p53 signaling pathway_Homo sapiens_hsa041151.23631071
40Spliceosome_Homo sapiens_hsa030401.22170017
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19833187
42Sulfur relay system_Homo sapiens_hsa041221.19446639
43Apoptosis_Homo sapiens_hsa042101.18008273
44Salmonella infection_Homo sapiens_hsa051321.16532613
45Epstein-Barr virus infection_Homo sapiens_hsa051691.11761931
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11115693
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10168709
48RNA degradation_Homo sapiens_hsa030181.08517852
49Shigellosis_Homo sapiens_hsa051311.07606021
50Influenza A_Homo sapiens_hsa051641.03918236
51One carbon pool by folate_Homo sapiens_hsa006701.02583130
52Pentose phosphate pathway_Homo sapiens_hsa000301.02564423
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02433747
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01668792
55Caffeine metabolism_Homo sapiens_hsa002321.01315442
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99506837
57Viral carcinogenesis_Homo sapiens_hsa052030.98526832
58Hepatitis B_Homo sapiens_hsa051610.97616352
59Collecting duct acid secretion_Homo sapiens_hsa049660.97559456
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.96857290
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95138091
62Toxoplasmosis_Homo sapiens_hsa051450.93466377
63Amoebiasis_Homo sapiens_hsa051460.92947278
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91700513
65Fatty acid elongation_Homo sapiens_hsa000620.89572411
66N-Glycan biosynthesis_Homo sapiens_hsa005100.89335549
67Autoimmune thyroid disease_Homo sapiens_hsa053200.88347398
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87881889
69Viral myocarditis_Homo sapiens_hsa054160.86853971
70HIF-1 signaling pathway_Homo sapiens_hsa040660.86336785
71RNA transport_Homo sapiens_hsa030130.84686632
72Pertussis_Homo sapiens_hsa051330.84383939
73Osteoclast differentiation_Homo sapiens_hsa043800.82867966
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82353912
75Arachidonic acid metabolism_Homo sapiens_hsa005900.82235332
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.80041757
77Endocytosis_Homo sapiens_hsa041440.78164345
78TNF signaling pathway_Homo sapiens_hsa046680.78073923
79HTLV-I infection_Homo sapiens_hsa051660.76536884
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75384463
81Asthma_Homo sapiens_hsa053100.75286094
82Tuberculosis_Homo sapiens_hsa051520.75238600
83Fanconi anemia pathway_Homo sapiens_hsa034600.75208072
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74993700
85Thyroid cancer_Homo sapiens_hsa052160.74692004
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74526141
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74239100
88Glutathione metabolism_Homo sapiens_hsa004800.74034041
89Pancreatic cancer_Homo sapiens_hsa052120.71745342
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71554809
91B cell receptor signaling pathway_Homo sapiens_hsa046620.70139230
92Small cell lung cancer_Homo sapiens_hsa052220.69856886
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69462527
94Chronic myeloid leukemia_Homo sapiens_hsa052200.69160839
95T cell receptor signaling pathway_Homo sapiens_hsa046600.68870909
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.68509527
97Proteoglycans in cancer_Homo sapiens_hsa052050.67130039
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65955487
99Linoleic acid metabolism_Homo sapiens_hsa005910.63993987
100Hepatitis C_Homo sapiens_hsa051600.63974873
101Sulfur metabolism_Homo sapiens_hsa009200.63098992
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62863230
103Other glycan degradation_Homo sapiens_hsa005110.62248146
104Carbon metabolism_Homo sapiens_hsa012000.59662398
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59638442
106Rheumatoid arthritis_Homo sapiens_hsa053230.59611526
107Prion diseases_Homo sapiens_hsa050200.58122051
108Sphingolipid metabolism_Homo sapiens_hsa006000.57768161
109Regulation of autophagy_Homo sapiens_hsa041400.57629891
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.57473877
111Renal cell carcinoma_Homo sapiens_hsa052110.56817227
112Histidine metabolism_Homo sapiens_hsa003400.56646371
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56333929
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55215218
115Bladder cancer_Homo sapiens_hsa052190.51588120
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51488620
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.51369288
118TGF-beta signaling pathway_Homo sapiens_hsa043500.48697422
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48678965
120Notch signaling pathway_Homo sapiens_hsa043300.48484120
121Biosynthesis of amino acids_Homo sapiens_hsa012300.48140670
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47369891
123Phagosome_Homo sapiens_hsa041450.46580634
124Purine metabolism_Homo sapiens_hsa002300.45429616
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45283200
126Chemokine signaling pathway_Homo sapiens_hsa040620.44686186
127Lysosome_Homo sapiens_hsa041420.43294329
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42471009
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.41731283
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41722939
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41692201
132Steroid biosynthesis_Homo sapiens_hsa001000.41257887
133Endometrial cancer_Homo sapiens_hsa052130.40835225
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40035979

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