

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | metanephric mesenchyme development (GO:0072075) | 5.11262592 |
| 2 | kidney mesenchyme development (GO:0072074) | 4.79494317 |
| 3 | negative regulation of chondrocyte differentiation (GO:0032331) | 4.33375313 |
| 4 | neuron recognition (GO:0008038) | 4.01167337 |
| 5 | cornea development in camera-type eye (GO:0061303) | 3.94605942 |
| 6 | outer ear morphogenesis (GO:0042473) | 3.90638412 |
| 7 | bone trabecula formation (GO:0060346) | 3.86904017 |
| 8 | limb bud formation (GO:0060174) | 3.85837950 |
| 9 | collagen fibril organization (GO:0030199) | 3.82209817 |
| 10 | sequestering of extracellular ligand from receptor (GO:0035581) | 3.78877030 |
| 11 | chondrocyte proliferation (GO:0035988) | 3.72367465 |
| 12 | gamma-aminobutyric acid transport (GO:0015812) | 3.63351319 |
| 13 | axon extension (GO:0048675) | 3.59447162 |
| 14 | proximal/distal pattern formation (GO:0009954) | 3.53042116 |
| 15 | regulation of cardioblast proliferation (GO:0003264) | 3.40756773 |
| 16 | regulation of secondary heart field cardioblast proliferation (GO:0003266) | 3.40756773 |
| 17 | craniofacial suture morphogenesis (GO:0097094) | 3.38423744 |
| 18 | embryonic cranial skeleton morphogenesis (GO:0048701) | 3.36983037 |
| 19 | negative regulation of cartilage development (GO:0061037) | 3.34291293 |
| 20 | protein heterotrimerization (GO:0070208) | 3.30697834 |
| 21 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.26977442 |
| 22 | sympathetic nervous system development (GO:0048485) | 3.22355601 |
| 23 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.19062484 |
| 24 | negative regulation of keratinocyte proliferation (GO:0010839) | 3.15794990 |
| 25 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.11503335 |
| 26 | negative regulation of stem cell proliferation (GO:2000647) | 3.10335601 |
| 27 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.09885184 |
| 28 | negative regulation of fatty acid transport (GO:2000192) | 3.05301458 |
| 29 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 3.03919668 |
| 30 | camera-type eye morphogenesis (GO:0048593) | 3.01522660 |
| 31 | presynaptic membrane assembly (GO:0097105) | 3.00875564 |
| 32 | middle ear morphogenesis (GO:0042474) | 2.98918358 |
| 33 | neuron projection extension (GO:1990138) | 2.95984634 |
| 34 | positive regulation of synapse assembly (GO:0051965) | 2.94723370 |
| 35 | dendrite morphogenesis (GO:0048813) | 2.92918568 |
| 36 | dermatan sulfate biosynthetic process (GO:0030208) | 2.92658893 |
| 37 | auditory behavior (GO:0031223) | 2.90154678 |
| 38 | cochlea morphogenesis (GO:0090103) | 2.87635062 |
| 39 | regulation of axon guidance (GO:1902667) | 2.86673761 |
| 40 | regulation of glycogen (starch) synthase activity (GO:2000465) | 2.86268175 |
| 41 | regulation of hippo signaling (GO:0035330) | 2.86146027 |
| 42 | cranial suture morphogenesis (GO:0060363) | 2.85579494 |
| 43 | epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) | 2.85535879 |
| 44 | chondrocyte development (GO:0002063) | 2.83069874 |
| 45 | myoblast fusion (GO:0007520) | 2.78634456 |
| 46 | regulation of cartilage development (GO:0061035) | 2.78056483 |
| 47 | spinal cord development (GO:0021510) | 2.76201743 |
| 48 | gonadal mesoderm development (GO:0007506) | 2.75376628 |
| 49 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.75260074 |
| 50 | axon extension involved in axon guidance (GO:0048846) | 2.75260074 |
| 51 | mesenchyme morphogenesis (GO:0072132) | 2.75201786 |
| 52 | positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190) | 2.74685067 |
| 53 | presynaptic membrane organization (GO:0097090) | 2.73427765 |
| 54 | embryonic body morphogenesis (GO:0010172) | 2.73253471 |
| 55 | negative regulation of glycogen biosynthetic process (GO:0045719) | 2.73172524 |
| 56 | limb development (GO:0060173) | 2.71965130 |
| 57 | appendage development (GO:0048736) | 2.71965130 |
| 58 | somite development (GO:0061053) | 2.71780620 |
| 59 | regulation of chondrocyte differentiation (GO:0032330) | 2.71756436 |
| 60 | nonmotile primary cilium assembly (GO:0035058) | 2.71704873 |
| 61 | hindlimb morphogenesis (GO:0035137) | 2.71356226 |
| 62 | extracellular fibril organization (GO:0043206) | 2.71278863 |
| 63 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.70909911 |
| 64 | pharyngeal system development (GO:0060037) | 2.70341327 |
| 65 | embryonic hindlimb morphogenesis (GO:0035116) | 2.69565325 |
| 66 | hippo signaling (GO:0035329) | 2.68256059 |
| 67 | myoblast migration (GO:0051451) | 2.68054861 |
| 68 | negative regulation of axon guidance (GO:1902668) | 2.67637004 |
| 69 | cerebellar granule cell differentiation (GO:0021707) | 2.67347523 |
| 70 | urinary tract smooth muscle contraction (GO:0014848) | 2.67313039 |
| 71 | extracellular regulation of signal transduction (GO:1900115) | 2.65095234 |
| 72 | extracellular negative regulation of signal transduction (GO:1900116) | 2.65095234 |
| 73 | cell migration in hindbrain (GO:0021535) | 2.64664425 |
| 74 | regulation of heart morphogenesis (GO:2000826) | 2.64473561 |
| 75 | paraxial mesoderm development (GO:0048339) | 2.64133778 |
| 76 | embryonic digit morphogenesis (GO:0042733) | 2.64083179 |
| 77 | desmosome organization (GO:0002934) | 2.63910075 |
| 78 | regulation of synapse assembly (GO:0051963) | 2.63320517 |
| 79 | neuron cell-cell adhesion (GO:0007158) | 2.62129116 |
| 80 | nucleobase catabolic process (GO:0046113) | 2.61880037 |
| 81 | positive regulation of cartilage development (GO:0061036) | 2.61037337 |
| 82 | embryonic forelimb morphogenesis (GO:0035115) | 2.60688276 |
| 83 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 2.60685852 |
| 84 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.60625936 |
| 85 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.60441875 |
| 86 | dermatan sulfate metabolic process (GO:0030205) | 2.60293354 |
| 87 | regulation of branching involved in ureteric bud morphogenesis (GO:0090189) | 2.59994869 |
| 88 | outflow tract septum morphogenesis (GO:0003148) | 2.59554645 |
| 89 | regulation of mesenchymal cell proliferation (GO:0010464) | 2.58928876 |
| 90 | postsynaptic membrane organization (GO:0001941) | 2.56974614 |
| 91 | mesenchyme development (GO:0060485) | 2.55796095 |
| 92 | axonal fasciculation (GO:0007413) | 2.55665387 |
| 93 | neural crest cell development (GO:0014032) | 2.55350392 |
| 94 | negative chemotaxis (GO:0050919) | 2.54984834 |
| 95 | ephrin receptor signaling pathway (GO:0048013) | 2.54838827 |
| 96 | myotube differentiation (GO:0014902) | 2.54560066 |
| 97 | peripheral nervous system neuron development (GO:0048935) | 2.54452644 |
| 98 | generation of neurons (GO:0048699) | 2.54411218 |
| 99 | organ induction (GO:0001759) | 2.54043167 |
| 100 | positive regulation of mesonephros development (GO:0061213) | 2.53900441 |
| 101 | positive regulation of mesenchymal cell proliferation (GO:0002053) | 2.53372240 |
| 102 | artery development (GO:0060840) | 2.52910180 |
| 103 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.51296260 |
| 104 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.51023374 |
| 105 | embryonic skeletal joint morphogenesis (GO:0060272) | 2.50239054 |
| 106 | vocalization behavior (GO:0071625) | 2.50034266 |
| 107 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.47856656 |
| 108 | cardiac right ventricle morphogenesis (GO:0003215) | 2.46576459 |
| 109 | suckling behavior (GO:0001967) | 2.45830478 |
| 110 | synapse assembly (GO:0007416) | 2.45203521 |
| 111 | regulation of mesonephros development (GO:0061217) | 2.44298606 |
| 112 | retinal ganglion cell axon guidance (GO:0031290) | 2.44231073 |
| 113 | regulation of cell proliferation involved in heart morphogenesis (GO:2000136) | 2.43836527 |
| 114 | body morphogenesis (GO:0010171) | 2.43451521 |
| 115 | otic vesicle formation (GO:0030916) | 2.42538575 |
| 116 | asymmetric protein localization (GO:0008105) | 2.42388458 |
| 117 | syncytium formation by plasma membrane fusion (GO:0000768) | 2.42114833 |
| 118 | cell aggregation (GO:0098743) | 2.40572618 |
| 119 | cartilage condensation (GO:0001502) | 2.40572618 |
| 120 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.40439526 |
| 121 | establishment of monopolar cell polarity (GO:0061162) | 2.40439526 |
| 122 | neuron fate specification (GO:0048665) | 2.40031676 |
| 123 | central nervous system neuron axonogenesis (GO:0021955) | 2.39568976 |
| 124 | inner ear receptor stereocilium organization (GO:0060122) | 2.39459639 |
| 125 | heart valve morphogenesis (GO:0003179) | 2.39418962 |
| 126 | lateral sprouting from an epithelium (GO:0060601) | 2.38487103 |
| 127 | establishment of planar polarity (GO:0001736) | 2.38451688 |
| 128 | establishment of tissue polarity (GO:0007164) | 2.38451688 |
| 129 | mating behavior (GO:0007617) | 2.38324309 |
| 130 | mechanosensory behavior (GO:0007638) | 2.37462446 |
| 131 | synaptic transmission, glutamatergic (GO:0035249) | 2.36657273 |
| 132 | plasma membrane repair (GO:0001778) | 2.36548452 |
| 133 | embryonic appendage morphogenesis (GO:0035113) | 2.36543687 |
| 134 | embryonic limb morphogenesis (GO:0030326) | 2.36543687 |
| 135 | cranial nerve morphogenesis (GO:0021602) | 2.36465291 |
| 136 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.36128600 |
| 137 | establishment of mitochondrion localization (GO:0051654) | 2.35910611 |
| 138 | lymphangiogenesis (GO:0001946) | 2.35734295 |
| 139 | endocardial cushion morphogenesis (GO:0003203) | 2.34815452 |
| 140 | forelimb morphogenesis (GO:0035136) | 2.34336453 |
| 141 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.34224457 |
| 142 | negative regulation of catenin import into nucleus (GO:0035414) | 2.34157065 |
| 143 | gastrulation with mouth forming second (GO:0001702) | 2.34136942 |
| 144 | sex differentiation (GO:0007548) | 2.33789792 |
| 145 | positive regulation of gastrulation (GO:2000543) | 2.33718623 |
| 146 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.33198387 |
| 147 | regulation of organ formation (GO:0003156) | 2.32664886 |
| 148 | neuron remodeling (GO:0016322) | 2.32176860 |
| 149 | positive regulation of osteoblast differentiation (GO:0045669) | 2.32028118 |
| 150 | glial cell proliferation (GO:0014009) | 2.31989224 |
| 151 | heart valve formation (GO:0003188) | 2.31637911 |
| 152 | neuron migration (GO:0001764) | 2.31506397 |
| 153 | smooth muscle tissue development (GO:0048745) | 2.31485718 |
| 154 | developmental cell growth (GO:0048588) | 2.31036575 |
| 155 | protein localization to cilium (GO:0061512) | 2.30887940 |
| 156 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.30655622 |
| 157 | cell proliferation in forebrain (GO:0021846) | 2.30543288 |
| 158 | cell differentiation involved in kidney development (GO:0061005) | 2.30498146 |
| 159 | startle response (GO:0001964) | 2.30456718 |
| 160 | negative regulation of glycogen metabolic process (GO:0070874) | 2.30371133 |
| 161 | cell-cell signaling involved in cell fate commitment (GO:0045168) | 2.30337623 |
| 162 | cell proliferation involved in kidney development (GO:0072111) | 2.30290723 |
| 163 | regulation of establishment of planar polarity (GO:0090175) | 2.29898178 |
| 164 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.29677322 |
| 165 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052 | 2.29511110 |
| 166 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.29291607 |
| 167 | keratinocyte development (GO:0003334) | 2.28594252 |
| 168 | myelination in peripheral nervous system (GO:0022011) | 2.28162323 |
| 169 | peripheral nervous system axon ensheathment (GO:0032292) | 2.28162323 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.76558077 |
| 2 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.86042122 |
| 3 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.62499089 |
| 4 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.56844453 |
| 5 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.55529535 |
| 6 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.45372304 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.41500290 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.41500290 |
| 9 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.37493519 |
| 10 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.35559411 |
| 11 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.30115676 |
| 12 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.28574726 |
| 13 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.28486552 |
| 14 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.18853473 |
| 15 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.15825222 |
| 16 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.15383663 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.15009455 |
| 18 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.13723823 |
| 19 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 2.12674231 |
| 20 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.09204477 |
| 21 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.91483081 |
| 22 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.89480946 |
| 23 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.83764827 |
| 24 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.79749305 |
| 25 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.78131965 |
| 26 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.73549093 |
| 27 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.71215986 |
| 28 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.70261913 |
| 29 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.69075403 |
| 30 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.69043436 |
| 31 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.68723600 |
| 32 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.67963405 |
| 33 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.64538763 |
| 34 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.63223847 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 1.62696643 |
| 36 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.62347593 |
| 37 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.60094233 |
| 38 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.57219570 |
| 39 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.55695539 |
| 40 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.55077566 |
| 41 | CJUN_26792858_Chip-Seq_BT549_Human | 1.53213044 |
| 42 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.52057659 |
| 43 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.51672275 |
| 44 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.51386930 |
| 45 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.51117986 |
| 46 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.49148114 |
| 47 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.49148114 |
| 48 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.46235920 |
| 49 | * TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.46171796 |
| 50 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.45787681 |
| 51 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.44096555 |
| 52 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.44088801 |
| 53 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.43125363 |
| 54 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.43044008 |
| 55 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.39585285 |
| 56 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.37025962 |
| 57 | P300_19829295_ChIP-Seq_ESCs_Human | 1.36256032 |
| 58 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.35929896 |
| 59 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 1.34045669 |
| 60 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.34021860 |
| 61 | FUS_26573619_Chip-Seq_HEK293_Human | 1.33158320 |
| 62 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.32902445 |
| 63 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.32829235 |
| 64 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.31507575 |
| 65 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.31418141 |
| 66 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.29703328 |
| 67 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.29703328 |
| 68 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.28787551 |
| 69 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.27860547 |
| 70 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.25830015 |
| 71 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.24401524 |
| 72 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.24097580 |
| 73 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.24021569 |
| 74 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.23790231 |
| 75 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.23552048 |
| 76 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.21770011 |
| 77 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.21441766 |
| 78 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.21425414 |
| 79 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.19652110 |
| 80 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.18432750 |
| 81 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.18277457 |
| 82 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.16969081 |
| 83 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.16673458 |
| 84 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.15803184 |
| 85 | * STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.15108062 |
| 86 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.14633859 |
| 87 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.14281453 |
| 88 | * TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.13260962 |
| 89 | * TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.13229982 |
| 90 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.11853267 |
| 91 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.11349900 |
| 92 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.11298374 |
| 93 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.11128285 |
| 94 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.10206179 |
| 95 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.09857834 |
| 96 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.09268841 |
| 97 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.08790077 |
| 98 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.08351138 |
| 99 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08112860 |
| 100 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.07852054 |
| 101 | EWS_26573619_Chip-Seq_HEK293_Human | 1.07076518 |
| 102 | AR_25329375_ChIP-Seq_VCAP_Human | 1.06240537 |
| 103 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.06208978 |
| 104 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.05448065 |
| 105 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.05201834 |
| 106 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.04971617 |
| 107 | STAT3_23295773_ChIP-Seq_U87_Human | 1.04602038 |
| 108 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.04567393 |
| 109 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03316729 |
| 110 | AR_19668381_ChIP-Seq_PC3_Human | 1.00499122 |
| 111 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99891985 |
| 112 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.99848034 |
| 113 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.99704805 |
| 114 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99282791 |
| 115 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.99269266 |
| 116 | TP53_16413492_ChIP-PET_HCT116_Human | 0.98883319 |
| 117 | JUN_21703547_ChIP-Seq_K562_Human | 0.97903339 |
| 118 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.97733609 |
| 119 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.97551630 |
| 120 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.97379828 |
| 121 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.96637891 |
| 122 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.93535844 |
| 123 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.92919915 |
| 124 | TCF4_23295773_ChIP-Seq_U87_Human | 0.90918634 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005503_abnormal_tendon_morphology | 4.42745995 |
| 2 | MP0010030_abnormal_orbit_morphology | 3.91549760 |
| 3 | MP0008438_abnormal_cutaneous_collagen | 3.88438272 |
| 4 | MP0005275_abnormal_skin_tensile | 3.02527821 |
| 5 | MP0003385_abnormal_body_wall | 2.70228906 |
| 6 | MP0003122_maternal_imprinting | 2.45427813 |
| 7 | MP0009250_abnormal_appendicular_skeleto | 2.41349433 |
| 8 | MP0003705_abnormal_hypodermis_morpholog | 2.40427245 |
| 9 | MP0009053_abnormal_anal_canal | 2.40066464 |
| 10 | MP0008789_abnormal_olfactory_epithelium | 2.28166317 |
| 11 | MP0005394_taste/olfaction_phenotype | 1.98404820 |
| 12 | MP0005499_abnormal_olfactory_system | 1.98404820 |
| 13 | MP0000534_abnormal_ureter_morphology | 1.96514636 |
| 14 | MP0003755_abnormal_palate_morphology | 1.92401884 |
| 15 | MP0002249_abnormal_larynx_morphology | 1.92112592 |
| 16 | MP0000049_abnormal_middle_ear | 1.90446673 |
| 17 | MP0000537_abnormal_urethra_morphology | 1.88151521 |
| 18 | MP0000566_synostosis | 1.87134866 |
| 19 | MP0003942_abnormal_urinary_system | 1.85545316 |
| 20 | MP0003941_abnormal_skin_development | 1.81868710 |
| 21 | MP0005508_abnormal_skeleton_morphology | 1.78509246 |
| 22 | MP0003279_aneurysm | 1.77343376 |
| 23 | MP0004272_abnormal_basement_membrane | 1.76112771 |
| 24 | MP0001346_abnormal_lacrimal_gland | 1.69841928 |
| 25 | MP0000678_abnormal_parathyroid_gland | 1.69561897 |
| 26 | MP0002233_abnormal_nose_morphology | 1.68308763 |
| 27 | MP0005248_abnormal_Harderian_gland | 1.68272868 |
| 28 | MP0001299_abnormal_eye_distance/ | 1.64833818 |
| 29 | MP0003937_abnormal_limbs/digits/tail_de | 1.61933869 |
| 30 | MP0002108_abnormal_muscle_morphology | 1.61690639 |
| 31 | MP0000762_abnormal_tongue_morphology | 1.61547745 |
| 32 | MP0000428_abnormal_craniofacial_morphol | 1.49219086 |
| 33 | MP0000013_abnormal_adipose_tissue | 1.47343255 |
| 34 | MP0003121_genomic_imprinting | 1.46269970 |
| 35 | MP0005257_abnormal_intraocular_pressure | 1.45305131 |
| 36 | MP0005423_abnormal_somatic_nervous | 1.38269141 |
| 37 | MP0002282_abnormal_trachea_morphology | 1.34682984 |
| 38 | MP0009780_abnormal_chondrocyte_physiolo | 1.34680185 |
| 39 | MP0000569_abnormal_digit_pigmentation | 1.34227753 |
| 40 | MP0001958_emphysema | 1.32980179 |
| 41 | MP0002060_abnormal_skin_morphology | 1.30521126 |
| 42 | MP0005171_absent_coat_pigmentation | 1.29041119 |
| 43 | MP0004133_heterotaxia | 1.28173226 |
| 44 | MP0004233_abnormal_muscle_weight | 1.27553464 |
| 45 | MP0002697_abnormal_eye_size | 1.25975427 |
| 46 | MP0000778_abnormal_nervous_system | 1.24779488 |
| 47 | MP0003935_abnormal_craniofacial_develop | 1.24613519 |
| 48 | MP0003787_abnormal_imprinting | 1.23277097 |
| 49 | MP0002177_abnormal_outer_ear | 1.23255382 |
| 50 | MP0000516_abnormal_urinary_system | 1.23215169 |
| 51 | MP0005367_renal/urinary_system_phenotyp | 1.23215169 |
| 52 | MP0002116_abnormal_craniofacial_bone | 1.21809458 |
| 53 | MP0005623_abnormal_meninges_morphology | 1.20734241 |
| 54 | MP0002932_abnormal_joint_morphology | 1.20386613 |
| 55 | MP0003119_abnormal_digestive_system | 1.20229351 |
| 56 | MP0002938_white_spotting | 1.19712625 |
| 57 | MP0001177_atelectasis | 1.17603769 |
| 58 | MP0000955_abnormal_spinal_cord | 1.16633079 |
| 59 | MP0004859_abnormal_synaptic_plasticity | 1.15729635 |
| 60 | MP0003123_paternal_imprinting | 1.14999640 |
| 61 | MP0004134_abnormal_chest_morphology | 1.14901086 |
| 62 | MP0004885_abnormal_endolymph | 1.14289840 |
| 63 | MP0002653_abnormal_ependyma_morphology | 1.13856349 |
| 64 | MP0001529_abnormal_vocalization | 1.13453197 |
| 65 | MP0002751_abnormal_autonomic_nervous | 1.11866169 |
| 66 | MP0001984_abnormal_olfaction | 1.10727257 |
| 67 | MP0000163_abnormal_cartilage_morphology | 1.08699262 |
| 68 | MP0003115_abnormal_respiratory_system | 1.08478794 |
| 69 | MP0004270_analgesia | 1.08144022 |
| 70 | MP0002896_abnormal_bone_mineralization | 1.07009863 |
| 71 | MP0002109_abnormal_limb_morphology | 1.06640677 |
| 72 | MP0000579_abnormal_nail_morphology | 1.06039525 |
| 73 | MP0009384_cardiac_valve_regurgitation | 1.05745895 |
| 74 | MP0002160_abnormal_reproductive_system | 1.04068892 |
| 75 | MP0004858_abnormal_nervous_system | 1.02718969 |
| 76 | MP0001849_ear_inflammation | 1.02695131 |
| 77 | MP0002572_abnormal_emotion/affect_behav | 1.01145555 |
| 78 | MP0002115_abnormal_skeleton_extremities | 1.00514532 |
| 79 | MP0001286_abnormal_eye_development | 0.99623236 |
| 80 | MP0002184_abnormal_innervation | 0.99210534 |
| 81 | MP0004142_abnormal_muscle_tone | 0.98833726 |
| 82 | MP0003315_abnormal_perineum_morphology | 0.97721999 |
| 83 | MP0000432_abnormal_head_morphology | 0.96693581 |
| 84 | MP0002882_abnormal_neuron_morphology | 0.95867404 |
| 85 | MP0001270_distended_abdomen | 0.95233863 |
| 86 | MP0003890_abnormal_embryonic-extraembry | 0.94297653 |
| 87 | MP0003938_abnormal_ear_development | 0.94004227 |
| 88 | MP0009046_muscle_twitch | 0.93784399 |
| 89 | MP0002877_abnormal_melanocyte_morpholog | 0.93585171 |
| 90 | MP0000647_abnormal_sebaceous_gland | 0.93578330 |
| 91 | MP0002272_abnormal_nervous_system | 0.91783314 |
| 92 | MP0002168_other_aberrant_phenotype | 0.91216514 |
| 93 | MP0002152_abnormal_brain_morphology | 0.89738038 |
| 94 | MP0000026_abnormal_inner_ear | 0.88442788 |
| 95 | MP0003880_abnormal_central_pattern | 0.88326391 |
| 96 | MP0005646_abnormal_pituitary_gland | 0.87729388 |
| 97 | MP0000733_abnormal_muscle_development | 0.86437576 |
| 98 | MP0002752_abnormal_somatic_nervous | 0.85931346 |
| 99 | MP0002114_abnormal_axial_skeleton | 0.85930334 |
| 100 | MP0001340_abnormal_eyelid_morphology | 0.84989772 |
| 101 | MP0002557_abnormal_social/conspecific_i | 0.84690570 |
| 102 | MP0001293_anophthalmia | 0.83488352 |
| 103 | MP0001879_abnormal_lymphatic_vessel | 0.83153872 |
| 104 | MP0000383_abnormal_hair_follicle | 0.82840002 |
| 105 | MP0005187_abnormal_penis_morphology | 0.82566327 |
| 106 | MP0001324_abnormal_eye_pigmentation | 0.82435021 |
| 107 | MP0002736_abnormal_nociception_after | 0.81767415 |
| 108 | MP0005197_abnormal_uvea_morphology | 0.80193653 |
| 109 | MP0002822_catalepsy | 0.78878915 |
| 110 | MP0003635_abnormal_synaptic_transmissio | 0.78374358 |
| 111 | MP0002102_abnormal_ear_morphology | 0.78277674 |
| 112 | MP0000631_abnormal_neuroendocrine_gland | 0.77866789 |
| 113 | MP0002295_abnormal_pulmonary_circulatio | 0.77787130 |
| 114 | MP0002081_perinatal_lethality | 0.77159258 |
| 115 | MP0000767_abnormal_smooth_muscle | 0.76039369 |
| 116 | MP0000751_myopathy | 0.75942120 |
| 117 | MP0002113_abnormal_skeleton_development | 0.75540007 |
| 118 | MP0002063_abnormal_learning/memory/cond | 0.75387851 |
| 119 | MP0003283_abnormal_digestive_organ | 0.75162460 |
| 120 | MP0006276_abnormal_autonomic_nervous | 0.74942263 |
| 121 | MP0002734_abnormal_mechanical_nocicepti | 0.72082135 |
| 122 | MP0006292_abnormal_olfactory_placode | 0.71190755 |
| 123 | MP0001188_hyperpigmentation | 0.71119280 |
| 124 | MP0000613_abnormal_salivary_gland | 0.71022248 |
| 125 | MP0002234_abnormal_pharynx_morphology | 0.70931464 |
| 126 | MP0000467_abnormal_esophagus_morphology | 0.70401238 |
| 127 | MP0003861_abnormal_nervous_system | 0.69489682 |
| 128 | MP0002254_reproductive_system_inflammat | 0.69407009 |
| 129 | MP0002735_abnormal_chemical_nociception | 0.69041609 |
| 130 | MP0002111_abnormal_tail_morphology | 0.69009611 |
| 131 | MP0010234_abnormal_vibrissa_follicle | 0.68701372 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 4.12465585 |
| 2 | Premature rupture of membranes (HP:0001788) | 3.76035039 |
| 3 | Shallow orbits (HP:0000586) | 3.42382912 |
| 4 | Short 4th metacarpal (HP:0010044) | 3.38130463 |
| 5 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.38130463 |
| 6 | Asymmetry of the thorax (HP:0001555) | 3.34775738 |
| 7 | Atrophic scars (HP:0001075) | 3.10819356 |
| 8 | Abnormality of dentin (HP:0010299) | 2.97717755 |
| 9 | Follicular hyperkeratosis (HP:0007502) | 2.96841845 |
| 10 | Popliteal pterygium (HP:0009756) | 2.78012990 |
| 11 | Abnormality of the 4th metacarpal (HP:0010012) | 2.77712288 |
| 12 | Midline defect of the nose (HP:0004122) | 2.60748625 |
| 13 | Morphological abnormality of the middle ear (HP:0008609) | 2.59907456 |
| 14 | Soft skin (HP:0000977) | 2.59616931 |
| 15 | Microglossia (HP:0000171) | 2.59304234 |
| 16 | Bladder diverticulum (HP:0000015) | 2.58255556 |
| 17 | Broad metatarsal (HP:0001783) | 2.56817059 |
| 18 | Fragile skin (HP:0001030) | 2.54652001 |
| 19 | Ankle contracture (HP:0006466) | 2.53668181 |
| 20 | Wrist flexion contracture (HP:0001239) | 2.52675494 |
| 21 | Mesomelia (HP:0003027) | 2.51820443 |
| 22 | Infantile muscular hypotonia (HP:0008947) | 2.44961614 |
| 23 | Cutaneous finger syndactyly (HP:0010554) | 2.42865681 |
| 24 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.42710053 |
| 25 | True hermaphroditism (HP:0010459) | 2.34444295 |
| 26 | Neonatal short-limb short stature (HP:0008921) | 2.27613375 |
| 27 | Overgrowth (HP:0001548) | 2.27050263 |
| 28 | Spinal rigidity (HP:0003306) | 2.22328122 |
| 29 | Aortic dissection (HP:0002647) | 2.21576156 |
| 30 | Bell-shaped thorax (HP:0001591) | 2.20635880 |
| 31 | Wormian bones (HP:0002645) | 2.19811793 |
| 32 | Hepatoblastoma (HP:0002884) | 2.16893706 |
| 33 | Lip pit (HP:0100267) | 2.15779934 |
| 34 | Pancreatic fibrosis (HP:0100732) | 2.15001938 |
| 35 | Abnormality of the aortic arch (HP:0012303) | 2.09757019 |
| 36 | Type 1 muscle fiber predominance (HP:0003803) | 2.09520052 |
| 37 | Vascular tortuosity (HP:0004948) | 2.08185158 |
| 38 | Concave nail (HP:0001598) | 2.06786718 |
| 39 | Hypoplastic pelvis (HP:0008839) | 2.06268429 |
| 40 | Synostosis involving the elbow (HP:0003938) | 2.05749371 |
| 41 | Humeroradial synostosis (HP:0003041) | 2.05749371 |
| 42 | Abnormality of the nasal septum (HP:0000419) | 2.05025871 |
| 43 | Calcaneovalgus deformity (HP:0001848) | 2.05015838 |
| 44 | Spinal cord lesions (HP:0100561) | 2.04196108 |
| 45 | Syringomyelia (HP:0003396) | 2.04196108 |
| 46 | Cutaneous syndactyly (HP:0012725) | 2.03333169 |
| 47 | Dilatation of the ascending aorta (HP:0005111) | 2.03021830 |
| 48 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 2.00147687 |
| 49 | Wide anterior fontanel (HP:0000260) | 1.99767997 |
| 50 | Gait imbalance (HP:0002141) | 1.97705321 |
| 51 | Aortic aneurysm (HP:0004942) | 1.96716248 |
| 52 | Keratoconus (HP:0000563) | 1.96209792 |
| 53 | Increased corneal curvature (HP:0100692) | 1.96209792 |
| 54 | Deviation of the hallux (HP:0010051) | 1.96135123 |
| 55 | Coronal craniosynostosis (HP:0004440) | 1.95571388 |
| 56 | Molar tooth sign on MRI (HP:0002419) | 1.93903230 |
| 57 | Abnormality of midbrain morphology (HP:0002418) | 1.93903230 |
| 58 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.92866765 |
| 59 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.90105646 |
| 60 | Failure to thrive in infancy (HP:0001531) | 1.89499599 |
| 61 | Natal tooth (HP:0000695) | 1.88482360 |
| 62 | Short nail (HP:0001799) | 1.87241187 |
| 63 | Genetic anticipation (HP:0003743) | 1.86634458 |
| 64 | Broad ribs (HP:0000885) | 1.83256984 |
| 65 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.83061465 |
| 66 | Bowel diverticulosis (HP:0005222) | 1.82561011 |
| 67 | Smooth philtrum (HP:0000319) | 1.82260327 |
| 68 | Hypoplastic labia majora (HP:0000059) | 1.81345567 |
| 69 | Chorioretinal atrophy (HP:0000533) | 1.81235088 |
| 70 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.80418311 |
| 71 | Pancreatic cysts (HP:0001737) | 1.79716250 |
| 72 | Aplasia cutis congenita (HP:0001057) | 1.79603479 |
| 73 | Papillary thyroid carcinoma (HP:0002895) | 1.79388384 |
| 74 | Deformed tarsal bones (HP:0008119) | 1.78887826 |
| 75 | Subacute progressive viral hepatitis (HP:0006572) | 1.78617103 |
| 76 | Broad long bones (HP:0005622) | 1.78344829 |
| 77 | Abnormality of the labia majora (HP:0012881) | 1.77680653 |
| 78 | Pterygium (HP:0001059) | 1.77533546 |
| 79 | Abnormality of the parietal bone (HP:0002696) | 1.77411581 |
| 80 | Broad toe (HP:0001837) | 1.76583234 |
| 81 | Hallux valgus (HP:0001822) | 1.76469381 |
| 82 | Nephronophthisis (HP:0000090) | 1.76281932 |
| 83 | Cervical subluxation (HP:0003308) | 1.75892764 |
| 84 | Joint laxity (HP:0001388) | 1.75658542 |
| 85 | Bronchomalacia (HP:0002780) | 1.75489544 |
| 86 | Arterial tortuosity (HP:0005116) | 1.75146056 |
| 87 | Abnormality of the ischium (HP:0003174) | 1.73831613 |
| 88 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.73229650 |
| 89 | Buphthalmos (HP:0000557) | 1.73067798 |
| 90 | Blue sclerae (HP:0000592) | 1.72757749 |
| 91 | Narrow nasal bridge (HP:0000446) | 1.71674665 |
| 92 | Abnormal number of incisors (HP:0011064) | 1.71514656 |
| 93 | Absent phalangeal crease (HP:0006109) | 1.71401749 |
| 94 | Lower limb amyotrophy (HP:0007210) | 1.71180977 |
| 95 | Poor coordination (HP:0002370) | 1.70954164 |
| 96 | Pheochromocytoma (HP:0002666) | 1.70950091 |
| 97 | Tarsal synostosis (HP:0008368) | 1.70856452 |
| 98 | Hyperextensible skin (HP:0000974) | 1.69788347 |
| 99 | Increased number of teeth (HP:0011069) | 1.67935288 |
| 100 | Megalencephaly (HP:0001355) | 1.67577089 |
| 101 | Genital tract atresia (HP:0001827) | 1.66753752 |
| 102 | Absent eyebrow (HP:0002223) | 1.66335206 |
| 103 | Down-sloping shoulders (HP:0200021) | 1.66097453 |
| 104 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.65762036 |
| 105 | Hypoplasia of the maxilla (HP:0000327) | 1.65700560 |
| 106 | Congenital primary aphakia (HP:0007707) | 1.64405405 |
| 107 | Vaginal atresia (HP:0000148) | 1.63828313 |
| 108 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.63473357 |
| 109 | Camptodactyly of toe (HP:0001836) | 1.63459396 |
| 110 | Increased connective tissue (HP:0009025) | 1.63436631 |
| 111 | Scrotal hypoplasia (HP:0000046) | 1.62527727 |
| 112 | Sclerocornea (HP:0000647) | 1.62030682 |
| 113 | Hip dysplasia (HP:0001385) | 1.61918725 |
| 114 | Neoplasm of the heart (HP:0100544) | 1.61838797 |
| 115 | Limited hip movement (HP:0008800) | 1.61663327 |
| 116 | Anencephaly (HP:0002323) | 1.60879594 |
| 117 | Fibular aplasia (HP:0002990) | 1.60697631 |
| 118 | Protruding ear (HP:0000411) | 1.60649590 |
| 119 | Preauricular pit (HP:0004467) | 1.60554831 |
| 120 | Periauricular skin pits (HP:0100277) | 1.60554831 |
| 121 | Cystic liver disease (HP:0006706) | 1.60078274 |
| 122 | Biconcave vertebral bodies (HP:0004586) | 1.59661586 |
| 123 | Broad phalanx (HP:0006009) | 1.59394862 |
| 124 | Radial bowing (HP:0002986) | 1.58989548 |
| 125 | Genu recurvatum (HP:0002816) | 1.58410512 |
| 126 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 1.58376860 |
| 127 | Exostoses (HP:0100777) | 1.57530576 |
| 128 | Medial flaring of the eyebrow (HP:0010747) | 1.57156496 |
| 129 | Hypoplastic ischia (HP:0003175) | 1.57138716 |
| 130 | Aplasia of the phalanges of the hand (HP:0009802) | 1.57016253 |
| 131 | Aplasia involving bones of the extremities (HP:0009825) | 1.57016253 |
| 132 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.57016253 |
| 133 | Mitral valve prolapse (HP:0001634) | 1.56789535 |
| 134 | Short foot (HP:0001773) | 1.56292913 |
| 135 | Scapular winging (HP:0003691) | 1.55970780 |
| 136 | Broad finger (HP:0001500) | 1.55334094 |
| 137 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.55265696 |
| 138 | Turricephaly (HP:0000262) | 1.55130834 |
| 139 | Synostosis involving bones of the lower limbs (HP:0009138) | 1.54785275 |
| 140 | Synostosis involving bones of the feet (HP:0009140) | 1.54785275 |
| 141 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 1.54527290 |
| 142 | Short 1st metacarpal (HP:0010034) | 1.54527290 |
| 143 | Abnormal ciliary motility (HP:0012262) | 1.53529034 |
| 144 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.53398481 |
| 145 | Aqueductal stenosis (HP:0002410) | 1.53220250 |
| 146 | Broad thumb (HP:0011304) | 1.53030404 |
| 147 | Long clavicles (HP:0000890) | 1.52939004 |
| 148 | Mitral regurgitation (HP:0001653) | 1.52724773 |
| 149 | Fibular hypoplasia (HP:0003038) | 1.52651259 |
| 150 | Renal duplication (HP:0000075) | 1.52597997 |
| 151 | Renal dysplasia (HP:0000110) | 1.51877619 |
| 152 | Patellar aplasia (HP:0006443) | 1.50501327 |
| 153 | Tibial bowing (HP:0002982) | 1.49858051 |
| 154 | Preaxial hand polydactyly (HP:0001177) | 1.49817688 |
| 155 | Drooling (HP:0002307) | 1.49776854 |
| 156 | Volvulus (HP:0002580) | 1.47838135 |
| 157 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.47786934 |
| 158 | Absent/shortened dynein arms (HP:0200106) | 1.47786934 |
| 159 | Absent frontal sinuses (HP:0002688) | 1.47240729 |
| 160 | Hyperventilation (HP:0002883) | 1.46590355 |
| 161 | Vitreoretinal degeneration (HP:0000655) | 1.46343991 |
| 162 | Oligodactyly (HP:0012165) | 1.43040415 |
| 163 | Esophageal atresia (HP:0002032) | 1.42962613 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TNIK | 3.78641172 |
| 2 | SIK3 | 3.75801990 |
| 3 | FRK | 3.61835493 |
| 4 | PNCK | 3.53880268 |
| 5 | ERBB3 | 3.14980383 |
| 6 | CASK | 3.07789577 |
| 7 | MAP3K9 | 3.05102222 |
| 8 | DDR2 | 2.97294764 |
| 9 | LATS1 | 2.58210830 |
| 10 | MAP3K2 | 2.50514917 |
| 11 | LATS2 | 2.47048771 |
| 12 | STK38L | 2.45090737 |
| 13 | PLK2 | 2.40688608 |
| 14 | BCR | 2.23507540 |
| 15 | PINK1 | 2.22521308 |
| 16 | PDGFRA | 2.18067623 |
| 17 | EPHA4 | 2.06422505 |
| 18 | EPHB2 | 1.98632844 |
| 19 | MINK1 | 1.83494675 |
| 20 | NTRK3 | 1.81721312 |
| 21 | FER | 1.78835991 |
| 22 | KSR1 | 1.76298068 |
| 23 | MAPK15 | 1.69194485 |
| 24 | SGK2 | 1.68102292 |
| 25 | MARK1 | 1.60360398 |
| 26 | ZAK | 1.60130163 |
| 27 | TSSK6 | 1.51486288 |
| 28 | STK24 | 1.50989674 |
| 29 | EPHA2 | 1.43166899 |
| 30 | PRPF4B | 1.40880611 |
| 31 | WEE1 | 1.33793571 |
| 32 | SGK3 | 1.31925405 |
| 33 | FGFR2 | 1.31752002 |
| 34 | PRKD3 | 1.31131550 |
| 35 | SGK494 | 1.27668261 |
| 36 | SGK223 | 1.27668261 |
| 37 | TRIM28 | 1.27376087 |
| 38 | MAPK13 | 1.19099986 |
| 39 | MAP3K6 | 1.15900562 |
| 40 | FGFR1 | 1.13069336 |
| 41 | PAK3 | 1.12184016 |
| 42 | BMPR1B | 1.11509003 |
| 43 | PRKCH | 1.10969086 |
| 44 | DYRK3 | 1.10287405 |
| 45 | AKT3 | 1.05146728 |
| 46 | CAMK1G | 1.04067967 |
| 47 | STK3 | 1.03602444 |
| 48 | MAP2K1 | 1.01688898 |
| 49 | MAP3K3 | 1.00670491 |
| 50 | PTK2B | 0.99539825 |
| 51 | TTN | 0.98938362 |
| 52 | TAOK2 | 0.97616514 |
| 53 | BRD4 | 0.97381912 |
| 54 | MAP3K4 | 0.96406587 |
| 55 | LIMK1 | 0.95704610 |
| 56 | EPHA3 | 0.92957345 |
| 57 | CDK8 | 0.91900489 |
| 58 | PRKCE | 0.90777315 |
| 59 | PLK3 | 0.87740544 |
| 60 | RPS6KA2 | 0.87598470 |
| 61 | CSNK1G2 | 0.87349502 |
| 62 | SIK1 | 0.86962522 |
| 63 | MET | 0.86939408 |
| 64 | PTK2 | 0.85488793 |
| 65 | BMPR2 | 0.83564794 |
| 66 | WNK3 | 0.82206285 |
| 67 | ROCK1 | 0.81560966 |
| 68 | CDK3 | 0.75943023 |
| 69 | CAMKK1 | 0.75494592 |
| 70 | MAP2K7 | 0.75143224 |
| 71 | CDK18 | 0.74538900 |
| 72 | TESK1 | 0.74365931 |
| 73 | SIK2 | 0.73884697 |
| 74 | TYRO3 | 0.73748832 |
| 75 | CSNK1G1 | 0.73161081 |
| 76 | PRKCG | 0.71004426 |
| 77 | PAK6 | 0.70568704 |
| 78 | PAK2 | 0.66819360 |
| 79 | ARAF | 0.66113031 |
| 80 | PIK3CA | 0.64510106 |
| 81 | PDGFRB | 0.63726157 |
| 82 | TRPM7 | 0.63114587 |
| 83 | YES1 | 0.62528295 |
| 84 | CDK14 | 0.62127017 |
| 85 | NEK9 | 0.61482115 |
| 86 | CDC42BPA | 0.61374068 |
| 87 | ROCK2 | 0.60663957 |
| 88 | DYRK1A | 0.58890392 |
| 89 | NTRK1 | 0.58170013 |
| 90 | CDK12 | 0.57240120 |
| 91 | ILK | 0.56765397 |
| 92 | MAP2K4 | 0.56313085 |
| 93 | RPS6KL1 | 0.54351472 |
| 94 | RPS6KC1 | 0.54351472 |
| 95 | PTK6 | 0.54293143 |
| 96 | MOS | 0.54229373 |
| 97 | CAMK1D | 0.52707851 |
| 98 | CAMK2B | 0.51905609 |
| 99 | CDK15 | 0.50309687 |
| 100 | CAMK2A | 0.49761353 |
| 101 | NEK6 | 0.49533868 |
| 102 | CSNK1E | 0.48876236 |
| 103 | PKN2 | 0.47384775 |
| 104 | PRKCI | 0.47260370 |
| 105 | CDK5 | 0.46619915 |
| 106 | DMPK | 0.45935703 |
| 107 | CAMK4 | 0.45089710 |
| 108 | STK39 | 0.44742678 |
| 109 | ADRBK1 | 0.44621510 |
| 110 | DAPK2 | 0.44169991 |
| 111 | STK38 | 0.43430139 |
| 112 | MKNK2 | 0.43278211 |
| 113 | PHKG1 | 0.43115022 |
| 114 | PHKG2 | 0.43115022 |
| 115 | TGFBR1 | 0.43051932 |
| 116 | CDK7 | 0.42399909 |
| 117 | GRK1 | 0.42399435 |
| 118 | DYRK2 | 0.41833451 |
| 119 | BRSK2 | 0.41555966 |
| 120 | MUSK | 0.41401122 |
| 121 | RET | 0.41300613 |
| 122 | MTOR | 0.40944402 |
| 123 | MAP3K10 | 0.40602735 |
| 124 | ERBB2 | 0.40238557 |
| 125 | CSNK1A1L | 0.40016199 |
| 126 | MAPK10 | 0.40015567 |
| 127 | MKNK1 | 0.39988715 |
| 128 | NEK2 | 0.39740591 |
| 129 | MAPK8 | 0.39271695 |
| 130 | CDK6 | 0.39088257 |
| 131 | TRIB3 | 0.38937693 |
| 132 | ICK | 0.38889755 |
| 133 | SGK1 | 0.38861596 |
| 134 | RPS6KA6 | 0.38777157 |
| 135 | INSRR | 0.37571027 |
| 136 | CSNK1G3 | 0.37555110 |
| 137 | MYLK | 0.37392662 |
| 138 | RPS6KB1 | 0.37339865 |
| 139 | CDK11A | 0.35800552 |
| 140 | NTRK2 | 0.34909962 |
| 141 | WNK1 | 0.34401317 |
| 142 | NLK | 0.32814405 |
| 143 | FGFR3 | 0.31144125 |
| 144 | RIPK1 | 0.31007820 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Axon guidance_Homo sapiens_hsa04360 | 2.16092327 |
| 2 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.03539275 |
| 3 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.97913492 |
| 4 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.94867868 |
| 5 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.89647653 |
| 6 | Adherens junction_Homo sapiens_hsa04520 | 1.88658892 |
| 7 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.80277138 |
| 8 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.75524456 |
| 9 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.72998073 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.72396393 |
| 11 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.67279748 |
| 12 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.66255878 |
| 13 | Focal adhesion_Homo sapiens_hsa04510 | 1.60436300 |
| 14 | Olfactory transduction_Homo sapiens_hsa04740 | 1.60010481 |
| 15 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.58235666 |
| 16 | Circadian entrainment_Homo sapiens_hsa04713 | 1.55713461 |
| 17 | Gap junction_Homo sapiens_hsa04540 | 1.55485785 |
| 18 | Endometrial cancer_Homo sapiens_hsa05213 | 1.53595933 |
| 19 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.51677583 |
| 20 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.49357022 |
| 21 | Cocaine addiction_Homo sapiens_hsa05030 | 1.49319754 |
| 22 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.49201089 |
| 23 | Long-term potentiation_Homo sapiens_hsa04720 | 1.48147521 |
| 24 | Melanogenesis_Homo sapiens_hsa04916 | 1.48126508 |
| 25 | Nicotine addiction_Homo sapiens_hsa05033 | 1.47219005 |
| 26 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.44044170 |
| 27 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.40900208 |
| 28 | Glioma_Homo sapiens_hsa05214 | 1.38704427 |
| 29 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.38402910 |
| 30 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.36802287 |
| 31 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.35697017 |
| 32 | Melanoma_Homo sapiens_hsa05218 | 1.29291006 |
| 33 | Thyroid cancer_Homo sapiens_hsa05216 | 1.28323058 |
| 34 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.24751068 |
| 35 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.23828674 |
| 36 | Sulfur relay system_Homo sapiens_hsa04122 | 1.22443542 |
| 37 | Taste transduction_Homo sapiens_hsa04742 | 1.19880553 |
| 38 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.17077061 |
| 39 | Morphine addiction_Homo sapiens_hsa05032 | 1.16249692 |
| 40 | Phototransduction_Homo sapiens_hsa04744 | 1.15600986 |
| 41 | Colorectal cancer_Homo sapiens_hsa05210 | 1.14546166 |
| 42 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.13333617 |
| 43 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.13217035 |
| 44 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.12788571 |
| 45 | Renin secretion_Homo sapiens_hsa04924 | 1.12777420 |
| 46 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.12457472 |
| 47 | Prostate cancer_Homo sapiens_hsa05215 | 1.12085575 |
| 48 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.11436016 |
| 49 | Tight junction_Homo sapiens_hsa04530 | 1.11162674 |
| 50 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.09880545 |
| 51 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.09769365 |
| 52 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.09501436 |
| 53 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.09097350 |
| 54 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.05953647 |
| 55 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.05679826 |
| 56 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.04187193 |
| 57 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.03367686 |
| 58 | Insulin secretion_Homo sapiens_hsa04911 | 1.03165800 |
| 59 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.02142544 |
| 60 | Amoebiasis_Homo sapiens_hsa05146 | 1.01696616 |
| 61 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.01272015 |
| 62 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.00971997 |
| 63 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.99369866 |
| 64 | Salivary secretion_Homo sapiens_hsa04970 | 0.99095400 |
| 65 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.98658202 |
| 66 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.97192537 |
| 67 | Long-term depression_Homo sapiens_hsa04730 | 0.96907719 |
| 68 | GABAergic synapse_Homo sapiens_hsa04727 | 0.96714784 |
| 69 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.95809643 |
| 70 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.95612370 |
| 71 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.92866240 |
| 72 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.92305485 |
| 73 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.92182063 |
| 74 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.91762084 |
| 75 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.89631156 |
| 76 | Pathways in cancer_Homo sapiens_hsa05200 | 0.89391220 |
| 77 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.89335561 |
| 78 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.89151094 |
| 79 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.89030567 |
| 80 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.88846962 |
| 81 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.86652289 |
| 82 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.86521635 |
| 83 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.85058089 |
| 84 | Bladder cancer_Homo sapiens_hsa05219 | 0.83937763 |
| 85 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.80764130 |
| 86 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.80632369 |
| 87 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.78943755 |
| 88 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.77911324 |
| 89 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.75587961 |
| 90 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.75408328 |
| 91 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.74351304 |
| 92 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.71733003 |
| 93 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.70354720 |
| 94 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.68801332 |
| 95 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.68498401 |
| 96 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.68345302 |
| 97 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.68153955 |
| 98 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.66716305 |
| 99 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.66709877 |
| 100 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.66468793 |
| 101 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.64289626 |
| 102 | Circadian rhythm_Homo sapiens_hsa04710 | 0.63602633 |
| 103 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.63310884 |
| 104 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.63091419 |
| 105 | Basal transcription factors_Homo sapiens_hsa03022 | 0.62342910 |
| 106 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.60863971 |
| 107 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.59002556 |
| 108 | Phagosome_Homo sapiens_hsa04145 | 0.58740760 |
| 109 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.57240367 |
| 110 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.56811765 |
| 111 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.55504659 |
| 112 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.53289738 |
| 113 | HTLV-I infection_Homo sapiens_hsa05166 | 0.52689855 |
| 114 | Cell cycle_Homo sapiens_hsa04110 | 0.51708798 |
| 115 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.51157829 |
| 116 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.49568717 |
| 117 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.47299250 |
| 118 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.42632209 |
| 119 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.42069157 |
| 120 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.40336987 |
| 121 | Alcoholism_Homo sapiens_hsa05034 | 0.39678409 |

