

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.78569831 |
| 2 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.66307901 |
| 3 | vocalization behavior (GO:0071625) | 5.66000013 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.57352413 |
| 5 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.52588942 |
| 6 | locomotory exploration behavior (GO:0035641) | 5.45817250 |
| 7 | protein localization to synapse (GO:0035418) | 5.43846205 |
| 8 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.26114229 |
| 9 | glutamate receptor signaling pathway (GO:0007215) | 5.24953012 |
| 10 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.10054935 |
| 11 | exploration behavior (GO:0035640) | 5.09839250 |
| 12 | neuron cell-cell adhesion (GO:0007158) | 4.99993106 |
| 13 | synaptic vesicle exocytosis (GO:0016079) | 4.91035430 |
| 14 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.85314428 |
| 15 | neuron recognition (GO:0008038) | 4.73325158 |
| 16 | glutamate secretion (GO:0014047) | 4.70766132 |
| 17 | synaptic transmission, glutamatergic (GO:0035249) | 4.67715612 |
| 18 | synaptic vesicle maturation (GO:0016188) | 4.61943048 |
| 19 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.54857501 |
| 20 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.51354558 |
| 21 | dendritic spine morphogenesis (GO:0060997) | 4.48792489 |
| 22 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.35141016 |
| 23 | neuron-neuron synaptic transmission (GO:0007270) | 4.34673594 |
| 24 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.20652338 |
| 25 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.17390637 |
| 26 | synaptic vesicle endocytosis (GO:0048488) | 4.12203743 |
| 27 | positive regulation of synapse maturation (GO:0090129) | 4.11370368 |
| 28 | neuronal action potential propagation (GO:0019227) | 4.10546578 |
| 29 | axonal fasciculation (GO:0007413) | 4.08544644 |
| 30 | regulation of synaptic vesicle transport (GO:1902803) | 4.08512591 |
| 31 | regulation of dendritic spine morphogenesis (GO:0061001) | 4.08427976 |
| 32 | long-term memory (GO:0007616) | 4.07960564 |
| 33 | serotonin metabolic process (GO:0042428) | 4.07545045 |
| 34 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 4.00720710 |
| 35 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.99256631 |
| 36 | layer formation in cerebral cortex (GO:0021819) | 3.98488000 |
| 37 | behavioral fear response (GO:0001662) | 3.98385576 |
| 38 | behavioral defense response (GO:0002209) | 3.98385576 |
| 39 | regulation of postsynaptic membrane potential (GO:0060078) | 3.96702663 |
| 40 | dendritic spine organization (GO:0097061) | 3.95623959 |
| 41 | regulation of synaptic plasticity (GO:0048167) | 3.90560409 |
| 42 | glycerophospholipid catabolic process (GO:0046475) | 3.89325245 |
| 43 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.88511342 |
| 44 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.85821195 |
| 45 | long-term synaptic potentiation (GO:0060291) | 3.85718491 |
| 46 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.81178849 |
| 47 | primary amino compound metabolic process (GO:1901160) | 3.77399102 |
| 48 | proline transport (GO:0015824) | 3.77240038 |
| 49 | neurotransmitter secretion (GO:0007269) | 3.76043469 |
| 50 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.75154039 |
| 51 | positive regulation of membrane potential (GO:0045838) | 3.74477906 |
| 52 | fear response (GO:0042596) | 3.72240005 |
| 53 | regulation of synapse structural plasticity (GO:0051823) | 3.66282864 |
| 54 | postsynaptic membrane organization (GO:0001941) | 3.64369384 |
| 55 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.62446247 |
| 56 | innervation (GO:0060384) | 3.61911068 |
| 57 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.56766157 |
| 58 | positive regulation of dendritic spine development (GO:0060999) | 3.56299537 |
| 59 | presynaptic membrane assembly (GO:0097105) | 3.55438319 |
| 60 | epithelial cell fate commitment (GO:0072148) | 3.51602258 |
| 61 | transmission of nerve impulse (GO:0019226) | 3.51582644 |
| 62 | regulation of dendritic spine development (GO:0060998) | 3.50993563 |
| 63 | regulation of vesicle fusion (GO:0031338) | 3.50057136 |
| 64 | regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315) | 3.49132280 |
| 65 | response to histamine (GO:0034776) | 3.49067437 |
| 66 | regulation of glutamate secretion (GO:0014048) | 3.44628597 |
| 67 | chemosensory behavior (GO:0007635) | 3.35832915 |
| 68 | learning (GO:0007612) | 3.33218535 |
| 69 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.29119102 |
| 70 | cellular potassium ion homeostasis (GO:0030007) | 3.26806086 |
| 71 | gamma-aminobutyric acid transport (GO:0015812) | 3.25129739 |
| 72 | neurotransmitter transport (GO:0006836) | 3.23459733 |
| 73 | regulation of female receptivity (GO:0045924) | 3.22182068 |
| 74 | presynaptic membrane organization (GO:0097090) | 3.22028837 |
| 75 | cochlea development (GO:0090102) | 3.18368886 |
| 76 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.17455097 |
| 77 | vesicle transport along microtubule (GO:0047496) | 3.17179009 |
| 78 | membrane depolarization (GO:0051899) | 3.16061243 |
| 79 | regulation of synapse maturation (GO:0090128) | 3.14685462 |
| 80 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.14132670 |
| 81 | long term synaptic depression (GO:0060292) | 3.13521221 |
| 82 | glycosphingolipid biosynthetic process (GO:0006688) | 3.12579532 |
| 83 | dendrite morphogenesis (GO:0048813) | 3.11523459 |
| 84 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.10282526 |
| 85 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 3.10112225 |
| 86 | potassium ion homeostasis (GO:0055075) | 3.10027268 |
| 87 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.09954014 |
| 88 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.08942557 |
| 89 | righting reflex (GO:0060013) | 3.07848679 |
| 90 | regulation of neurotransmitter secretion (GO:0046928) | 3.07640078 |
| 91 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.07480423 |
| 92 | neurotransmitter uptake (GO:0001504) | 3.05684167 |
| 93 | brain morphogenesis (GO:0048854) | 3.04604340 |
| 94 | startle response (GO:0001964) | 3.04490391 |
| 95 | detection of calcium ion (GO:0005513) | 3.03679780 |
| 96 | potassium ion import (GO:0010107) | 3.02811325 |
| 97 | potassium ion transmembrane transport (GO:0071805) | 3.02568188 |
| 98 | cellular potassium ion transport (GO:0071804) | 3.02568188 |
| 99 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.02134427 |
| 100 | response to amphetamine (GO:0001975) | 3.01853049 |
| 101 | positive regulation of neurotransmitter transport (GO:0051590) | 3.01762604 |
| 102 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 3.01619951 |
| 103 | regulation of synaptic transmission (GO:0050804) | 3.01446008 |
| 104 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 3.00012711 |
| 105 | regulation of axon regeneration (GO:0048679) | 2.99992281 |
| 106 | regulation of neuron projection regeneration (GO:0070570) | 2.99992281 |
| 107 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.99074596 |
| 108 | inner ear receptor cell development (GO:0060119) | 2.99050200 |
| 109 | membrane depolarization during action potential (GO:0086010) | 2.98174278 |
| 110 | behavioral response to cocaine (GO:0048148) | 2.96936583 |
| 111 | female mating behavior (GO:0060180) | 2.96661833 |
| 112 | intraspecies interaction between organisms (GO:0051703) | 2.95521760 |
| 113 | social behavior (GO:0035176) | 2.95521760 |
| 114 | cell communication by electrical coupling (GO:0010644) | 2.95229155 |
| 115 | regulation of neurotransmitter levels (GO:0001505) | 2.94701153 |
| 116 | synaptic transmission (GO:0007268) | 2.92742894 |
| 117 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.92271884 |
| 118 | neuromuscular process controlling balance (GO:0050885) | 2.91507480 |
| 119 | insulin secretion (GO:0030073) | 2.90913896 |
| 120 | astrocyte differentiation (GO:0048708) | 2.89184545 |
| 121 | positive regulation of meiosis (GO:0045836) | 2.88417170 |
| 122 | potassium ion transport (GO:0006813) | 2.84967170 |
| 123 | regulation of neurotransmitter transport (GO:0051588) | 2.80884333 |
| 124 | regulation of neurotransmitter uptake (GO:0051580) | 2.79385108 |
| 125 | neuronal action potential (GO:0019228) | 2.77454092 |
| 126 | reflex (GO:0060004) | 2.77016207 |
| 127 | positive regulation of vesicle fusion (GO:0031340) | 2.74996980 |
| 128 | regulation of synaptic transmission, dopaminergic (GO:0032225) | 2.71879345 |
| 129 | membrane repolarization (GO:0086009) | 2.70402788 |
| 130 | membrane repolarization during action potential (GO:0086011) | 2.68279883 |
| 131 | sodium ion export (GO:0071436) | 2.66916515 |
| 132 | membrane hyperpolarization (GO:0060081) | 2.66815239 |
| 133 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.64215951 |
| 134 | positive regulation of meiotic cell cycle (GO:0051446) | 2.63303784 |
| 135 | atrial cardiac muscle cell action potential (GO:0086014) | 2.62118942 |
| 136 | alanine transport (GO:0032328) | 2.61485964 |
| 137 | negative regulation of hormone biosynthetic process (GO:0032353) | 2.61106645 |
| 138 | positive regulation of gluconeogenesis (GO:0045722) | 2.59530175 |
| 139 | cardiac conduction (GO:0061337) | 2.58475154 |
| 140 | dopamine transport (GO:0015872) | 2.58344374 |
| 141 | regulation of heart rate by cardiac conduction (GO:0086091) | 2.58236938 |
| 142 | auditory behavior (GO:0031223) | 2.56991867 |
| 143 | catecholamine transport (GO:0051937) | 2.55731521 |
| 144 | multicellular organismal signaling (GO:0035637) | 2.53702468 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.70880371 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.06580269 |
| 3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.40059682 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.32050620 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.26953925 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.14214985 |
| 7 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.85489380 |
| 8 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.81988174 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.74260470 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.74260470 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.73041650 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.64349012 |
| 13 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.57049321 |
| 14 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.56826488 |
| 15 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.54696305 |
| 16 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.48606437 |
| 17 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.47696394 |
| 18 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.36771705 |
| 19 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.23318869 |
| 20 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.22492522 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.19732713 |
| 22 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.17560802 |
| 23 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.13244848 |
| 24 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.12870331 |
| 25 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.11198479 |
| 26 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.00543057 |
| 27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.95411617 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.86618740 |
| 29 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.81177973 |
| 30 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.80372281 |
| 31 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.79082119 |
| 32 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.78736706 |
| 33 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.70729490 |
| 34 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.68649086 |
| 35 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.67362697 |
| 36 | P300_19829295_ChIP-Seq_ESCs_Human | 1.63233748 |
| 37 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.61113049 |
| 38 | FUS_26573619_Chip-Seq_HEK293_Human | 1.55460599 |
| 39 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.53797730 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.53484104 |
| 41 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.48255569 |
| 42 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.47080130 |
| 43 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.46195906 |
| 44 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.44608072 |
| 45 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.43257677 |
| 46 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.42940045 |
| 47 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.42435646 |
| 48 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.41778103 |
| 49 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.41089047 |
| 50 | AR_25329375_ChIP-Seq_VCAP_Human | 1.39428258 |
| 51 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.38959562 |
| 52 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.35972924 |
| 53 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.35266886 |
| 54 | VDR_22108803_ChIP-Seq_LS180_Human | 1.34773232 |
| 55 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.33113305 |
| 56 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.31933096 |
| 57 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.31875114 |
| 58 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.29865511 |
| 59 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.29295054 |
| 60 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.27751309 |
| 61 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.27502115 |
| 62 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.26016025 |
| 63 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.23641688 |
| 64 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.21916351 |
| 65 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.21803865 |
| 66 | STAT3_23295773_ChIP-Seq_U87_Human | 1.19312756 |
| 67 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.18476323 |
| 68 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.17852281 |
| 69 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.16576671 |
| 70 | TP53_16413492_ChIP-PET_HCT116_Human | 1.16479544 |
| 71 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.15842818 |
| 72 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.15475348 |
| 73 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.15361433 |
| 74 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.15324935 |
| 75 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14981470 |
| 76 | JUN_21703547_ChIP-Seq_K562_Human | 1.12951962 |
| 77 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.12845455 |
| 78 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.12795168 |
| 79 | AR_19668381_ChIP-Seq_PC3_Human | 1.12664917 |
| 80 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.11693901 |
| 81 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.09981553 |
| 82 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.09678783 |
| 83 | TCF4_23295773_ChIP-Seq_U87_Human | 1.08992872 |
| 84 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.08092883 |
| 85 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.07297796 |
| 86 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.07271783 |
| 87 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.06640315 |
| 88 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.05729922 |
| 89 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.05489854 |
| 90 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.05430150 |
| 91 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.05287132 |
| 92 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.05025996 |
| 93 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.04171383 |
| 94 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.03928499 |
| 95 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.03794917 |
| 96 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.03188733 |
| 97 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.03146166 |
| 98 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.01616955 |
| 99 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.01399173 |
| 100 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01303644 |
| 101 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.01080439 |
| 102 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.00682028 |
| 103 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.00060954 |
| 104 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00060954 |
| 105 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.00049017 |
| 106 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.99740386 |
| 107 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.99645121 |
| 108 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.99494265 |
| 109 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.99440821 |
| 110 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.98111756 |
| 111 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.97927820 |
| 112 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.97829876 |
| 113 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.97778330 |
| 114 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.97773306 |
| 115 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.97611515 |
| 116 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.96771877 |
| 117 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.95993726 |
| 118 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.93488134 |
| 119 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.90974079 |
| 120 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.90032137 |
| 121 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.89661099 |
| 122 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.89383163 |
| 123 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.87935005 |
| 124 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.86438897 |
| 125 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.85931161 |
| 126 | KDM2B_26808549_Chip-Seq_REH_Human | 0.83323336 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 7.16985598 |
| 2 | MP0003880_abnormal_central_pattern | 5.98471712 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.29272208 |
| 4 | MP0004270_analgesia | 3.77060306 |
| 5 | MP0002063_abnormal_learning/memory/cond | 3.63147881 |
| 6 | MP0009745_abnormal_behavioral_response | 3.53457964 |
| 7 | MP0001968_abnormal_touch/_nociception | 3.15836954 |
| 8 | MP0002064_seizures | 3.06644422 |
| 9 | MP0002572_abnormal_emotion/affect_behav | 2.91665289 |
| 10 | MP0002736_abnormal_nociception_after | 2.77909506 |
| 11 | MP0002735_abnormal_chemical_nociception | 2.67467989 |
| 12 | MP0005379_endocrine/exocrine_gland_phen | 2.62628136 |
| 13 | MP0001501_abnormal_sleep_pattern | 2.59091463 |
| 14 | MP0003283_abnormal_digestive_organ | 2.56089753 |
| 15 | MP0002272_abnormal_nervous_system | 2.53024489 |
| 16 | MP0001440_abnormal_grooming_behavior | 2.47724770 |
| 17 | MP0009046_muscle_twitch | 2.37510208 |
| 18 | MP0002734_abnormal_mechanical_nocicepti | 2.34954693 |
| 19 | MP0001486_abnormal_startle_reflex | 2.32375083 |
| 20 | MP0002638_abnormal_pupillary_reflex | 2.29926970 |
| 21 | MP0000778_abnormal_nervous_system | 2.20361517 |
| 22 | MP0005423_abnormal_somatic_nervous | 2.15290382 |
| 23 | MP0003329_amyloid_beta_deposits | 2.10875292 |
| 24 | MP0002733_abnormal_thermal_nociception | 1.94880536 |
| 25 | MP0002184_abnormal_innervation | 1.93931534 |
| 26 | MP0006276_abnormal_autonomic_nervous | 1.91034272 |
| 27 | MP0009780_abnormal_chondrocyte_physiolo | 1.89939165 |
| 28 | MP0002067_abnormal_sensory_capabilities | 1.87964281 |
| 29 | MP0001970_abnormal_pain_threshold | 1.82245976 |
| 30 | MP0008877_abnormal_DNA_methylation | 1.80952476 |
| 31 | MP0004858_abnormal_nervous_system | 1.80781351 |
| 32 | MP0004133_heterotaxia | 1.80453344 |
| 33 | MP0002163_abnormal_gland_morphology | 1.79721441 |
| 34 | MP0002837_dystrophic_cardiac_calcinosis | 1.73998366 |
| 35 | MP0004811_abnormal_neuron_physiology | 1.68829652 |
| 36 | MP0002557_abnormal_social/conspecific_i | 1.68713417 |
| 37 | MP0005386_behavior/neurological_phenoty | 1.57647507 |
| 38 | MP0004924_abnormal_behavior | 1.57647507 |
| 39 | MP0000955_abnormal_spinal_cord | 1.53120398 |
| 40 | MP0001944_abnormal_pancreas_morphology | 1.50267037 |
| 41 | MP0003879_abnormal_hair_cell | 1.45555911 |
| 42 | MP0002909_abnormal_adrenal_gland | 1.44994431 |
| 43 | MP0002693_abnormal_pancreas_physiology | 1.43631424 |
| 44 | MP0004885_abnormal_endolymph | 1.42110470 |
| 45 | MP0002882_abnormal_neuron_morphology | 1.40791099 |
| 46 | MP0001905_abnormal_dopamine_level | 1.40036790 |
| 47 | MP0001188_hyperpigmentation | 1.38933614 |
| 48 | MP0001529_abnormal_vocalization | 1.38522143 |
| 49 | MP0008569_lethality_at_weaning | 1.38462590 |
| 50 | MP0003787_abnormal_imprinting | 1.37138867 |
| 51 | MP0002066_abnormal_motor_capabilities/c | 1.36144566 |
| 52 | MP0002822_catalepsy | 1.35703850 |
| 53 | MP0005645_abnormal_hypothalamus_physiol | 1.21757462 |
| 54 | MP0003633_abnormal_nervous_system | 1.20359865 |
| 55 | MP0001984_abnormal_olfaction | 1.19602940 |
| 56 | MP0001502_abnormal_circadian_rhythm | 1.19384132 |
| 57 | MP0004147_increased_porphyrin_level | 1.19191670 |
| 58 | MP0008875_abnormal_xenobiotic_pharmacok | 1.15057733 |
| 59 | MP0002152_abnormal_brain_morphology | 1.12663870 |
| 60 | MP0006292_abnormal_olfactory_placode | 1.07761789 |
| 61 | MP0006072_abnormal_retinal_apoptosis | 1.07340366 |
| 62 | MP0003631_nervous_system_phenotype | 1.06499389 |
| 63 | MP0004484_altered_response_of | 1.05607757 |
| 64 | MP0010329_abnormal_lipoprotein_level | 1.05294880 |
| 65 | MP0004019_abnormal_vitamin_homeostasis | 1.04898388 |
| 66 | MP0005409_darkened_coat_color | 1.04324672 |
| 67 | MP0004510_myositis | 1.03206432 |
| 68 | MP0004043_abnormal_pH_regulation | 1.01766894 |
| 69 | MP0003121_genomic_imprinting | 1.01619082 |
| 70 | MP0004145_abnormal_muscle_electrophysio | 1.00355676 |
| 71 | MP0000604_amyloidosis | 1.00117116 |
| 72 | MP0000751_myopathy | 0.99046402 |
| 73 | MP0005646_abnormal_pituitary_gland | 0.97265116 |
| 74 | MP0002069_abnormal_eating/drinking_beha | 0.92034789 |
| 75 | MP0004142_abnormal_muscle_tone | 0.92030586 |
| 76 | MP0002078_abnormal_glucose_homeostasis | 0.90436310 |
| 77 | MP0002234_abnormal_pharynx_morphology | 0.90258914 |
| 78 | MP0005187_abnormal_penis_morphology | 0.89424229 |
| 79 | MP0003122_maternal_imprinting | 0.88174134 |
| 80 | MP0005535_abnormal_body_temperature | 0.88006652 |
| 81 | MP0001963_abnormal_hearing_physiology | 0.87582559 |
| 82 | MP0009379_abnormal_foot_pigmentation | 0.85438117 |
| 83 | MP0002229_neurodegeneration | 0.85363990 |
| 84 | MP0002876_abnormal_thyroid_physiology | 0.82200998 |
| 85 | MP0004085_abnormal_heartbeat | 0.81527017 |
| 86 | MP0010386_abnormal_urinary_bladder | 0.81291880 |
| 87 | MP0010234_abnormal_vibrissa_follicle | 0.80684811 |
| 88 | MP0005448_abnormal_energy_balance | 0.80476146 |
| 89 | MP0008874_decreased_physiological_sensi | 0.80409392 |
| 90 | MP0003953_abnormal_hormone_level | 0.79931869 |
| 91 | MP0001756_abnormal_urination | 0.78471570 |
| 92 | MP0004742_abnormal_vestibular_system | 0.77967103 |
| 93 | MP0003075_altered_response_to | 0.77754769 |
| 94 | MP0000639_abnormal_adrenal_gland | 0.77652787 |
| 95 | MP0005551_abnormal_eye_electrophysiolog | 0.76472577 |
| 96 | MP0005332_abnormal_amino_acid | 0.75925335 |
| 97 | MP0002752_abnormal_somatic_nervous | 0.74728641 |
| 98 | MP0000013_abnormal_adipose_tissue | 0.74510760 |
| 99 | MP0003632_abnormal_nervous_system | 0.74475746 |
| 100 | MP0003634_abnormal_glial_cell | 0.74170736 |
| 101 | MP0005499_abnormal_olfactory_system | 0.72335388 |
| 102 | MP0005394_taste/olfaction_phenotype | 0.72335388 |
| 103 | MP0000631_abnormal_neuroendocrine_gland | 0.71019908 |
| 104 | MP0004215_abnormal_myocardial_fiber | 0.70778384 |
| 105 | MP0003172_abnormal_lysosome_physiology | 0.70763390 |
| 106 | MP0005253_abnormal_eye_physiology | 0.69399527 |
| 107 | MP0000427_abnormal_hair_cycle | 0.69088033 |
| 108 | MP0000566_synostosis | 0.68120745 |
| 109 | MP0000383_abnormal_hair_follicle | 0.67837394 |
| 110 | MP0008872_abnormal_physiological_respon | 0.67814669 |
| 111 | MP0001664_abnormal_digestion | 0.67584699 |
| 112 | MP0001485_abnormal_pinna_reflex | 0.67074251 |
| 113 | MP0001177_atelectasis | 0.66292640 |
| 114 | MP0005503_abnormal_tendon_morphology | 0.65852835 |
| 115 | MP0005636_abnormal_mineral_homeostasis | 0.65064619 |
| 116 | MP0003861_abnormal_nervous_system | 0.64300509 |
| 117 | MP0005171_absent_coat_pigmentation | 0.63373594 |
| 118 | MP0002938_white_spotting | 0.63102905 |
| 119 | MP0001986_abnormal_taste_sensitivity | 0.62964026 |
| 120 | MP0000026_abnormal_inner_ear | 0.61494141 |
| 121 | MP0003938_abnormal_ear_development | 0.60835093 |
| 122 | MP0008775_abnormal_heart_ventricle | 0.60610924 |
| 123 | MP0008961_abnormal_basal_metabolism | 0.59928574 |
| 124 | MP0004233_abnormal_muscle_weight | 0.58506451 |
| 125 | MP0000920_abnormal_myelination | 0.56239887 |
| 126 | MP0001765_abnormal_ion_homeostasis | 0.54386746 |
| 127 | MP0002102_abnormal_ear_morphology | 0.54318182 |
| 128 | MP0003137_abnormal_impulse_conducting | 0.53933557 |
| 129 | MP0000015_abnormal_ear_pigmentation | 0.48833202 |
| 130 | MP0005595_abnormal_vascular_smooth | 0.48176012 |
| 131 | MP0001943_abnormal_respiration | 0.47923654 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.32540002 |
| 2 | Visual hallucinations (HP:0002367) | 6.08175797 |
| 3 | Myokymia (HP:0002411) | 5.98231833 |
| 4 | Focal seizures (HP:0007359) | 5.87796424 |
| 5 | Epileptic encephalopathy (HP:0200134) | 5.14176969 |
| 6 | Atonic seizures (HP:0010819) | 4.74536733 |
| 7 | Hyperventilation (HP:0002883) | 4.63432755 |
| 8 | Absence seizures (HP:0002121) | 4.59252486 |
| 9 | Cerebral inclusion bodies (HP:0100314) | 4.51590602 |
| 10 | Dialeptic seizures (HP:0011146) | 4.36634052 |
| 11 | Febrile seizures (HP:0002373) | 4.26800818 |
| 12 | Supranuclear gaze palsy (HP:0000605) | 4.24222393 |
| 13 | Amblyopia (HP:0000646) | 4.02056269 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.99385587 |
| 15 | Progressive cerebellar ataxia (HP:0002073) | 3.95701993 |
| 16 | Broad-based gait (HP:0002136) | 3.70655833 |
| 17 | Neurofibrillary tangles (HP:0002185) | 3.66489026 |
| 18 | Excessive salivation (HP:0003781) | 3.63873310 |
| 19 | Drooling (HP:0002307) | 3.63873310 |
| 20 | Limb dystonia (HP:0002451) | 3.42412894 |
| 21 | Poor eye contact (HP:0000817) | 3.26598186 |
| 22 | Diplopia (HP:0000651) | 3.21830060 |
| 23 | Abnormality of binocular vision (HP:0011514) | 3.21830060 |
| 24 | Action tremor (HP:0002345) | 3.20007285 |
| 25 | Large for gestational age (HP:0001520) | 3.15789444 |
| 26 | Dysmetria (HP:0001310) | 3.10957909 |
| 27 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.10255171 |
| 28 | Anxiety (HP:0000739) | 3.07274103 |
| 29 | Epileptiform EEG discharges (HP:0011182) | 3.06971246 |
| 30 | Truncal ataxia (HP:0002078) | 3.05763507 |
| 31 | Hemiparesis (HP:0001269) | 2.97610855 |
| 32 | Gaze-evoked nystagmus (HP:0000640) | 2.92810867 |
| 33 | Mutism (HP:0002300) | 2.91875470 |
| 34 | Impaired social interactions (HP:0000735) | 2.90731414 |
| 35 | Abnormal social behavior (HP:0012433) | 2.90731414 |
| 36 | Delusions (HP:0000746) | 2.89333383 |
| 37 | Depression (HP:0000716) | 2.88613047 |
| 38 | Intestinal atresia (HP:0011100) | 2.81748208 |
| 39 | Dysdiadochokinesis (HP:0002075) | 2.80771726 |
| 40 | Termporal pattern (HP:0011008) | 2.77625979 |
| 41 | Insidious onset (HP:0003587) | 2.77625979 |
| 42 | EEG with generalized epileptiform discharges (HP:0011198) | 2.77366192 |
| 43 | Absent speech (HP:0001344) | 2.76568328 |
| 44 | Abnormality of the lower motor neuron (HP:0002366) | 2.72510386 |
| 45 | Prominent supraorbital ridges (HP:0000336) | 2.71907854 |
| 46 | Medial flaring of the eyebrow (HP:0010747) | 2.67967534 |
| 47 | Pancreatic fibrosis (HP:0100732) | 2.67738083 |
| 48 | Hypothermia (HP:0002045) | 2.65518750 |
| 49 | Progressive inability to walk (HP:0002505) | 2.64513146 |
| 50 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.57424199 |
| 51 | Hypsarrhythmia (HP:0002521) | 2.57373998 |
| 52 | Congenital sensorineural hearing impairment (HP:0008527) | 2.55378942 |
| 53 | Abnormal eating behavior (HP:0100738) | 2.54074708 |
| 54 | Amyotrophic lateral sclerosis (HP:0007354) | 2.51832561 |
| 55 | Postural instability (HP:0002172) | 2.51403818 |
| 56 | Impaired smooth pursuit (HP:0007772) | 2.49873936 |
| 57 | Occipital encephalocele (HP:0002085) | 2.49333208 |
| 58 | Sleep apnea (HP:0010535) | 2.47451338 |
| 59 | Abnormality of salivation (HP:0100755) | 2.45677876 |
| 60 | Papilledema (HP:0001085) | 2.45024761 |
| 61 | Gait imbalance (HP:0002141) | 2.44421009 |
| 62 | Generalized myoclonic seizures (HP:0002123) | 2.44391005 |
| 63 | Hypoplasia of the fovea (HP:0007750) | 2.43478436 |
| 64 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.43478436 |
| 65 | Hypoglycemic coma (HP:0001325) | 2.41929016 |
| 66 | Inability to walk (HP:0002540) | 2.41502164 |
| 67 | Bradykinesia (HP:0002067) | 2.41140546 |
| 68 | Stereotypic behavior (HP:0000733) | 2.38021084 |
| 69 | Ankle clonus (HP:0011448) | 2.37645857 |
| 70 | True hermaphroditism (HP:0010459) | 2.37600807 |
| 71 | Abnormality of the corticospinal tract (HP:0002492) | 2.36221384 |
| 72 | Hydroureter (HP:0000072) | 2.33003859 |
| 73 | Genetic anticipation (HP:0003743) | 2.32394682 |
| 74 | Abnormality of vitamin B metabolism (HP:0004340) | 2.29300976 |
| 75 | Urinary urgency (HP:0000012) | 2.27912218 |
| 76 | Postural tremor (HP:0002174) | 2.26367154 |
| 77 | Rapidly progressive (HP:0003678) | 2.24791708 |
| 78 | Congenital malformation of the right heart (HP:0011723) | 2.23047399 |
| 79 | Double outlet right ventricle (HP:0001719) | 2.23047399 |
| 80 | Psychosis (HP:0000709) | 2.21835683 |
| 81 | Fetal akinesia sequence (HP:0001989) | 2.19744603 |
| 82 | Abnormal biliary tract physiology (HP:0012439) | 2.18681514 |
| 83 | Bile duct proliferation (HP:0001408) | 2.18681514 |
| 84 | Type II lissencephaly (HP:0007260) | 2.16702726 |
| 85 | Hyperglycemia (HP:0003074) | 2.16180184 |
| 86 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.14880376 |
| 87 | Enlarged penis (HP:0000040) | 2.14570926 |
| 88 | Apathy (HP:0000741) | 2.14397113 |
| 89 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.13713993 |
| 90 | Thickened helices (HP:0000391) | 2.13492133 |
| 91 | Hypoglycemic seizures (HP:0002173) | 2.13191311 |
| 92 | Protruding tongue (HP:0010808) | 2.12891109 |
| 93 | Retinal dysplasia (HP:0007973) | 2.12276339 |
| 94 | Congenital primary aphakia (HP:0007707) | 2.11979694 |
| 95 | Inappropriate behavior (HP:0000719) | 2.11376914 |
| 96 | Spastic gait (HP:0002064) | 2.10434034 |
| 97 | Megalencephaly (HP:0001355) | 2.08616216 |
| 98 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.08516822 |
| 99 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.08515527 |
| 100 | Poor suck (HP:0002033) | 2.06087765 |
| 101 | Impaired vibratory sensation (HP:0002495) | 2.04821914 |
| 102 | Pancreatic cysts (HP:0001737) | 2.03099643 |
| 103 | Status epilepticus (HP:0002133) | 2.03073319 |
| 104 | Nephronophthisis (HP:0000090) | 2.01348294 |
| 105 | Prolonged QT interval (HP:0001657) | 2.00303356 |
| 106 | Hyperthyroidism (HP:0000836) | 2.00122371 |
| 107 | Lower limb muscle weakness (HP:0007340) | 1.99669786 |
| 108 | Intention tremor (HP:0002080) | 1.98758486 |
| 109 | Abnormal EKG (HP:0003115) | 1.96782669 |
| 110 | Polyphagia (HP:0002591) | 1.94118613 |
| 111 | Blue irides (HP:0000635) | 1.92696442 |
| 112 | Global brain atrophy (HP:0002283) | 1.90691921 |
| 113 | Scanning speech (HP:0002168) | 1.90641732 |
| 114 | Obstructive sleep apnea (HP:0002870) | 1.90256084 |
| 115 | Diminished motivation (HP:0000745) | 1.89303809 |
| 116 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.88928943 |
| 117 | Hypoplasia of the brainstem (HP:0002365) | 1.88928943 |
| 118 | Abnormality of the vitreous humor (HP:0004327) | 1.88730853 |
| 119 | Acute necrotizing encephalopathy (HP:0006965) | 1.88199779 |
| 120 | Abnormality of the fovea (HP:0000493) | 1.87399210 |
| 121 | Nephrogenic diabetes insipidus (HP:0009806) | 1.85868131 |
| 122 | Lower limb asymmetry (HP:0100559) | 1.84854059 |
| 123 | Gait ataxia (HP:0002066) | 1.84828188 |
| 124 | Severe muscular hypotonia (HP:0006829) | 1.84739419 |
| 125 | Ketoacidosis (HP:0001993) | 1.84511962 |
| 126 | Progressive macrocephaly (HP:0004481) | 1.84464407 |
| 127 | Focal dystonia (HP:0004373) | 1.84274001 |
| 128 | Short tibia (HP:0005736) | 1.82363326 |
| 129 | Optic nerve hypoplasia (HP:0000609) | 1.81559821 |
| 130 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.81081017 |
| 131 | Dysmetric saccades (HP:0000641) | 1.81001858 |
| 132 | Anosmia (HP:0000458) | 1.80616356 |
| 133 | Dysautonomia (HP:0002459) | 1.79875723 |
| 134 | Widely spaced teeth (HP:0000687) | 1.79548059 |
| 135 | Testicular atrophy (HP:0000029) | 1.78931428 |
| 136 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.78905222 |
| 137 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.78905222 |
| 138 | Aqueductal stenosis (HP:0002410) | 1.78559406 |
| 139 | Agitation (HP:0000713) | 1.78503572 |
| 140 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.78188348 |
| 141 | Incomplete penetrance (HP:0003829) | 1.78064143 |
| 142 | Neuronal loss in central nervous system (HP:0002529) | 1.77552328 |
| 143 | Syncope (HP:0001279) | 1.77470652 |
| 144 | Torticollis (HP:0000473) | 1.77363046 |
| 145 | Tubular atrophy (HP:0000092) | 1.77266818 |
| 146 | Insomnia (HP:0100785) | 1.75082555 |
| 147 | Volvulus (HP:0002580) | 1.74729055 |
| 148 | Cystic liver disease (HP:0006706) | 1.74516038 |
| 149 | Gastroesophageal reflux (HP:0002020) | 1.73627165 |
| 150 | Muscular hypotonia of the trunk (HP:0008936) | 1.68946651 |
| 151 | Supernumerary spleens (HP:0009799) | 1.68918111 |
| 152 | Genital tract atresia (HP:0001827) | 1.68674721 |
| 153 | Late onset (HP:0003584) | 1.67484002 |
| 154 | Abnormality of vitamin metabolism (HP:0100508) | 1.67438919 |
| 155 | Attenuation of retinal blood vessels (HP:0007843) | 1.67365470 |
| 156 | Unilateral renal agenesis (HP:0000122) | 1.66966093 |
| 157 | Tubulointerstitial nephritis (HP:0001970) | 1.65834975 |
| 158 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.65397376 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 5.08216627 |
| 2 | NTRK3 | 4.91608387 |
| 3 | MAP3K9 | 3.67883975 |
| 4 | MARK1 | 3.09788426 |
| 5 | RIPK4 | 3.01946360 |
| 6 | FRK | 2.96149021 |
| 7 | MAP3K4 | 2.90164047 |
| 8 | MINK1 | 2.78822655 |
| 9 | MAP3K12 | 2.61278586 |
| 10 | MAP4K2 | 2.50702402 |
| 11 | MAP2K7 | 2.44684261 |
| 12 | KSR2 | 2.19122374 |
| 13 | PLK2 | 2.18336022 |
| 14 | PNCK | 2.17167007 |
| 15 | KSR1 | 2.00107602 |
| 16 | CASK | 1.99387772 |
| 17 | MAP2K4 | 1.90667905 |
| 18 | DAPK1 | 1.89194784 |
| 19 | DAPK2 | 1.86946076 |
| 20 | GRK5 | 1.86446088 |
| 21 | ARAF | 1.83170313 |
| 22 | SIK2 | 1.79851148 |
| 23 | MAP3K13 | 1.78295998 |
| 24 | FGFR2 | 1.74363890 |
| 25 | PAK6 | 1.71409081 |
| 26 | NTRK2 | 1.68919501 |
| 27 | PTK2B | 1.63332454 |
| 28 | MST4 | 1.53861934 |
| 29 | NME1 | 1.53842454 |
| 30 | WNK4 | 1.51032421 |
| 31 | TNIK | 1.50920690 |
| 32 | PRKD3 | 1.49033935 |
| 33 | FES | 1.47204429 |
| 34 | NTRK1 | 1.46694051 |
| 35 | CDK5 | 1.45360757 |
| 36 | BMPR2 | 1.38740275 |
| 37 | FGR | 1.38060556 |
| 38 | PRKCG | 1.30463394 |
| 39 | CAMK2A | 1.26599395 |
| 40 | RAF1 | 1.23722124 |
| 41 | CAMKK1 | 1.17359171 |
| 42 | CAMK2B | 1.15932572 |
| 43 | GRK1 | 1.14972990 |
| 44 | PRPF4B | 1.14648900 |
| 45 | MAPK13 | 1.14168297 |
| 46 | GRK6 | 1.07308571 |
| 47 | MKNK2 | 1.06945767 |
| 48 | INSRR | 1.05483813 |
| 49 | CSNK1G1 | 1.04805131 |
| 50 | MAP3K2 | 1.04029982 |
| 51 | CCNB1 | 0.99103755 |
| 52 | MAP2K6 | 0.98324401 |
| 53 | AKT3 | 0.98275617 |
| 54 | STK38 | 0.97924137 |
| 55 | IRAK2 | 0.94840855 |
| 56 | CDK19 | 0.94072961 |
| 57 | ADRBK2 | 0.93477103 |
| 58 | DYRK1A | 0.93471627 |
| 59 | CSNK1G3 | 0.91717147 |
| 60 | LATS2 | 0.90761546 |
| 61 | TYRO3 | 0.89441550 |
| 62 | UHMK1 | 0.80898029 |
| 63 | MAP3K6 | 0.78657060 |
| 64 | STK38L | 0.77443411 |
| 65 | CDK14 | 0.75885650 |
| 66 | TAOK1 | 0.75686247 |
| 67 | ACVR1B | 0.75294816 |
| 68 | SGK2 | 0.74489409 |
| 69 | CDK18 | 0.73049048 |
| 70 | PHKG2 | 0.71882826 |
| 71 | PHKG1 | 0.71882826 |
| 72 | CAMK1 | 0.71342657 |
| 73 | CDK15 | 0.70974450 |
| 74 | STK11 | 0.70649945 |
| 75 | PAK3 | 0.69225740 |
| 76 | FER | 0.67867609 |
| 77 | SGK1 | 0.64897393 |
| 78 | MAPK15 | 0.63615256 |
| 79 | BMX | 0.62538285 |
| 80 | CDK11A | 0.62189633 |
| 81 | BRSK1 | 0.60166105 |
| 82 | CAMK2D | 0.58875269 |
| 83 | PRKCE | 0.56793829 |
| 84 | CSNK1G2 | 0.56116425 |
| 85 | MAP3K7 | 0.54018948 |
| 86 | RET | 0.53566419 |
| 87 | GRK7 | 0.53314598 |
| 88 | CAMK4 | 0.53174061 |
| 89 | PRKCZ | 0.52808270 |
| 90 | TLK1 | 0.52307205 |
| 91 | PRKCI | 0.51762939 |
| 92 | MARK2 | 0.51401200 |
| 93 | LIMK1 | 0.51316527 |
| 94 | SGK3 | 0.49898891 |
| 95 | DYRK2 | 0.48175758 |
| 96 | DMPK | 0.47542409 |
| 97 | PDK1 | 0.46738481 |
| 98 | FYN | 0.46647394 |
| 99 | OXSR1 | 0.46382262 |
| 100 | PRKAA1 | 0.44712486 |
| 101 | MAP3K1 | 0.44488982 |
| 102 | CSNK1A1 | 0.44322143 |
| 103 | PLK3 | 0.44100318 |
| 104 | CSNK1D | 0.43991906 |
| 105 | MUSK | 0.43786143 |
| 106 | MAP2K1 | 0.43508844 |
| 107 | BRAF | 0.40601243 |
| 108 | ALK | 0.39636051 |
| 109 | MAPK12 | 0.39524127 |
| 110 | MOS | 0.39261168 |
| 111 | PDPK1 | 0.38870580 |
| 112 | CAMK2G | 0.38817059 |
| 113 | ROCK2 | 0.38680763 |
| 114 | SGK223 | 0.36621595 |
| 115 | SGK494 | 0.36621595 |
| 116 | MAPK10 | 0.36106818 |
| 117 | RPS6KA3 | 0.35398011 |
| 118 | CAMKK2 | 0.34243546 |
| 119 | CAMK1G | 0.31880574 |
| 120 | PRKCH | 0.30427513 |
| 121 | PRKCQ | 0.30269263 |
| 122 | SYK | 0.30125615 |
| 123 | PINK1 | 0.29394334 |
| 124 | WNK3 | 0.28918327 |
| 125 | PRKCB | 0.27464670 |
| 126 | LMTK2 | 0.26972510 |
| 127 | PRKCA | 0.26901051 |
| 128 | PRKACA | 0.26271529 |
| 129 | CSNK1E | 0.25799719 |
| 130 | PKN1 | 0.25771154 |
| 131 | DAPK3 | 0.24358947 |
| 132 | BCR | 0.23621020 |
| 133 | PRKG1 | 0.22959908 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.31689183 |
| 2 | Long-term potentiation_Homo sapiens_hsa04720 | 3.27406912 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.92187605 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.85884378 |
| 5 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.78712858 |
| 6 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.77747964 |
| 7 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.71871659 |
| 8 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.71228972 |
| 9 | GABAergic synapse_Homo sapiens_hsa04727 | 2.57929397 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.40207822 |
| 11 | Olfactory transduction_Homo sapiens_hsa04740 | 2.38902639 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.33326719 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.24142845 |
| 14 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.17664508 |
| 15 | Taste transduction_Homo sapiens_hsa04742 | 1.93714211 |
| 16 | Long-term depression_Homo sapiens_hsa04730 | 1.92805306 |
| 17 | Renin secretion_Homo sapiens_hsa04924 | 1.92490971 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.89660126 |
| 19 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.85739264 |
| 20 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.81536272 |
| 21 | Insulin secretion_Homo sapiens_hsa04911 | 1.80607455 |
| 22 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.79199722 |
| 23 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.78235349 |
| 24 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.77527030 |
| 25 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.76253713 |
| 26 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.67110768 |
| 27 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.56622019 |
| 28 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.52095570 |
| 29 | Axon guidance_Homo sapiens_hsa04360 | 1.34924244 |
| 30 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.34310504 |
| 31 | Gap junction_Homo sapiens_hsa04540 | 1.34074714 |
| 32 | Cocaine addiction_Homo sapiens_hsa05030 | 1.32638315 |
| 33 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.28889496 |
| 34 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.28349058 |
| 35 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.26326854 |
| 36 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.25540853 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.24968085 |
| 38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.22889507 |
| 39 | Glioma_Homo sapiens_hsa05214 | 1.22274879 |
| 40 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.20357453 |
| 41 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.19564619 |
| 42 | Alzheimers disease_Homo sapiens_hsa05010 | 1.18821761 |
| 43 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.17696901 |
| 44 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.17621284 |
| 45 | Melanogenesis_Homo sapiens_hsa04916 | 1.16797793 |
| 46 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.16547771 |
| 47 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.14906167 |
| 48 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.12199122 |
| 49 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.11363157 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.11113567 |
| 51 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.09327242 |
| 52 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.02112004 |
| 53 | Phototransduction_Homo sapiens_hsa04744 | 1.02074193 |
| 54 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.99856305 |
| 55 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.97511374 |
| 56 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.96391119 |
| 57 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.96207599 |
| 58 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.95669665 |
| 59 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.94189536 |
| 60 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.94155922 |
| 61 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.91829789 |
| 62 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.86267637 |
| 63 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.84378524 |
| 64 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.83633540 |
| 65 | Mineral absorption_Homo sapiens_hsa04978 | 0.82445288 |
| 66 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.80247997 |
| 67 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.74716593 |
| 68 | ABC transporters_Homo sapiens_hsa02010 | 0.73372150 |
| 69 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73254655 |
| 70 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.71016889 |
| 71 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.70778378 |
| 72 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.67423611 |
| 73 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.67074079 |
| 74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.66858474 |
| 75 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.66649888 |
| 76 | Protein export_Homo sapiens_hsa03060 | 0.66627214 |
| 77 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.66127261 |
| 78 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.65981057 |
| 79 | Parkinsons disease_Homo sapiens_hsa05012 | 0.63946231 |
| 80 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.63130237 |
| 81 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.62443174 |
| 82 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.62032629 |
| 83 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.59716977 |
| 84 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.59586229 |
| 85 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.59025461 |
| 86 | Huntingtons disease_Homo sapiens_hsa05016 | 0.58583629 |
| 87 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.58294618 |
| 88 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.55534529 |
| 89 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.55465175 |
| 90 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.54525104 |
| 91 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.53698171 |
| 92 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.51004100 |
| 93 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.50963821 |
| 94 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.50004203 |
| 95 | Prion diseases_Homo sapiens_hsa05020 | 0.48437031 |
| 96 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.46620192 |
| 97 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.44910685 |
| 98 | Histidine metabolism_Homo sapiens_hsa00340 | 0.44064599 |
| 99 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.43768264 |
| 100 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.43666123 |
| 101 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.43009667 |
| 102 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.40787524 |
| 103 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.40505474 |
| 104 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.39978997 |
| 105 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.39760382 |
| 106 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.38971179 |
| 107 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.38960556 |
| 108 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.38516789 |
| 109 | Alcoholism_Homo sapiens_hsa05034 | 0.38222119 |
| 110 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.36991835 |
| 111 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.36706296 |
| 112 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.35667932 |
| 113 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.35662234 |
| 114 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.35110677 |
| 115 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.33399047 |
| 116 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.33035352 |
| 117 | Tight junction_Homo sapiens_hsa04530 | 0.32178393 |
| 118 | Peroxisome_Homo sapiens_hsa04146 | 0.28653053 |
| 119 | Endocytosis_Homo sapiens_hsa04144 | 0.28238480 |
| 120 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.27795695 |
| 121 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.27297497 |
| 122 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.27026956 |
| 123 | Bile secretion_Homo sapiens_hsa04976 | 0.26551003 |
| 124 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26451645 |
| 125 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.26183642 |
| 126 | Circadian rhythm_Homo sapiens_hsa04710 | 0.25942518 |
| 127 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.24687035 |
| 128 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.23870035 |
| 129 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.23283770 |
| 130 | Endometrial cancer_Homo sapiens_hsa05213 | 0.21515392 |
| 131 | Colorectal cancer_Homo sapiens_hsa05210 | 0.21309320 |
| 132 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.20062733 |
| 133 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.20052962 |

