SESN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)7.30208580
2muscle filament sliding (GO:0030049)7.30208580
3sarcoplasmic reticulum calcium ion transport (GO:0070296)6.85637263
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.57010420
5skeletal muscle contraction (GO:0003009)6.22745718
6regulation of skeletal muscle contraction (GO:0014819)6.15091474
7positive regulation of gamma-delta T cell activation (GO:0046645)5.94638519
8actin-mediated cell contraction (GO:0070252)5.86648263
9antigen processing and presentation via MHC class Ib (GO:0002475)5.34486659
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.31602854
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.31602854
12antigen processing and presentation of endogenous antigen (GO:0019883)4.98425589
13definitive hemopoiesis (GO:0060216)4.93129661
14creatine metabolic process (GO:0006600)4.84186615
15positive regulation of B cell differentiation (GO:0045579)4.78366734
16regulation of gamma-delta T cell differentiation (GO:0045586)4.76359615
17striated muscle contraction (GO:0006941)4.74734471
18positive regulation of respiratory burst (GO:0060267)4.73886410
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68520826
20megakaryocyte development (GO:0035855)4.56913754
21negative regulation of erythrocyte differentiation (GO:0045647)4.48776278
22actin filament-based movement (GO:0030048)4.38882423
23regulation of gamma-delta T cell activation (GO:0046643)4.35817663
24regulation of B cell receptor signaling pathway (GO:0050855)4.33644103
25regulation of relaxation of muscle (GO:1901077)4.21063479
26response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.15825967
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.15078720
28positive regulation of granulocyte differentiation (GO:0030854)4.11301850
29regulation of B cell differentiation (GO:0045577)4.05038948
30B cell receptor signaling pathway (GO:0050853)4.04988625
31mature B cell differentiation involved in immune response (GO:0002313)3.92487904
32positive thymic T cell selection (GO:0045059)3.91630270
33response to inactivity (GO:0014854)3.89836268
34relaxation of muscle (GO:0090075)3.78265578
35carnitine transmembrane transport (GO:1902603)3.60218978
36amino-acid betaine transport (GO:0015838)3.59753122
37carnitine transport (GO:0015879)3.59753122
38muscle contraction (GO:0006936)3.57307751
39skeletal muscle adaptation (GO:0043501)3.56365564
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.55038122
41negative regulation of cell killing (GO:0031342)3.55038122
42regulation of granulocyte differentiation (GO:0030852)3.53697052
43embryonic hemopoiesis (GO:0035162)3.52715260
44skeletal muscle fiber development (GO:0048741)3.51359658
45mast cell activation (GO:0045576)3.48463604
46glycogen catabolic process (GO:0005980)3.48228205
47mature B cell differentiation (GO:0002335)3.46200918
48neuronal action potential propagation (GO:0019227)3.45422397
49cardiac muscle hypertrophy (GO:0003300)3.42724346
50mucosal-associated lymphoid tissue development (GO:0048537)3.40500143
51Peyers patch development (GO:0048541)3.40500143
52regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40036111
53negative T cell selection (GO:0043383)3.35274444
54negative thymic T cell selection (GO:0045060)3.34972349
55angiogenesis involved in wound healing (GO:0060055)3.34318208
56mast cell activation involved in immune response (GO:0002279)3.33684115
57mast cell degranulation (GO:0043303)3.33684115
58oxygen transport (GO:0015671)3.33471221
59muscle system process (GO:0003012)3.31962467
60response to muscle activity (GO:0014850)3.31097468
61cardiac myofibril assembly (GO:0055003)3.31001905
62regulation of skeletal muscle cell differentiation (GO:2001014)3.29953120
63carnitine shuttle (GO:0006853)3.29756964
64negative regulation of granulocyte differentiation (GO:0030853)3.28397912
65striated muscle hypertrophy (GO:0014897)3.26851975
66negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25904370
67glucan catabolic process (GO:0009251)3.24848946
68regulation of respiratory burst (GO:0060263)3.24536402
69lymph node development (GO:0048535)3.24339028
70positive T cell selection (GO:0043368)3.19289796
71cellular polysaccharide catabolic process (GO:0044247)3.17109133
72glycogen biosynthetic process (GO:0005978)3.17054205
73glucan biosynthetic process (GO:0009250)3.17054205
74positive regulation of cation channel activity (GO:2001259)3.16147871
75regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.16129630
76regulation of interleukin-12 biosynthetic process (GO:0045075)3.15693310
77regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.14810394
78regulation of actin filament-based movement (GO:1903115)3.14612139
79myotube cell development (GO:0014904)3.14275035
80regulation of calcium ion transmembrane transport (GO:1903169)3.12204945
81regulation of calcium ion transmembrane transporter activity (GO:1901019)3.12204945
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.11872632
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06899836
84positive regulation of antigen processing and presentation (GO:0002579)3.06637624
85negative regulation of muscle contraction (GO:0045932)3.05700984
86actomyosin structure organization (GO:0031032)3.05579781
87response to interleukin-15 (GO:0070672)3.04917056
88neurotransmitter catabolic process (GO:0042135)3.04822469
89regulation of interferon-beta biosynthetic process (GO:0045357)3.03374599
90labyrinthine layer development (GO:0060711)3.02525352
91striated muscle adaptation (GO:0014888)3.01974262
92regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01130654
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00891086
94thymic T cell selection (GO:0045061)2.93165992
95polysaccharide catabolic process (GO:0000272)2.92900543
96regulation of striated muscle contraction (GO:0006942)2.91704231
97regulation of sarcomere organization (GO:0060297)2.90909770
98T cell homeostasis (GO:0043029)2.90273081
99muscle hypertrophy (GO:0014896)2.90099826
100regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.89306211
101natural killer cell differentiation (GO:0001779)2.88536948
102skeletal muscle tissue development (GO:0007519)2.87521089
103fatty acid transmembrane transport (GO:1902001)2.87318825
104cellular response to zinc ion (GO:0071294)2.86965765
105T cell selection (GO:0045058)2.86227650
106regulation of cardiac muscle cell contraction (GO:0086004)2.85743352
107regulation of regulatory T cell differentiation (GO:0045589)2.82389866
108quaternary ammonium group transport (GO:0015697)2.81016644
109regulation of erythrocyte differentiation (GO:0045646)2.80904834
110regulation of membrane repolarization (GO:0060306)2.80076543
111regulation of cell communication by electrical coupling (GO:0010649)2.79883991
112negative regulation of potassium ion transmembrane transport (GO:1901380)2.79679346
113macroautophagy (GO:0016236)2.79076987
114response to type I interferon (GO:0034340)2.75829368
115myofibril assembly (GO:0030239)2.75533215
116leukocyte homeostasis (GO:0001776)2.75419352
117cellular response to interleukin-15 (GO:0071350)2.75355289
118lymphocyte homeostasis (GO:0002260)2.74964021
119cellular response to thyroid hormone stimulus (GO:0097067)2.72744424
120muscle fiber development (GO:0048747)2.71674256
121barbed-end actin filament capping (GO:0051016)2.71064989
122necroptotic process (GO:0070266)2.69696019
123regulation of ARF protein signal transduction (GO:0032012)2.67755214
124mitotic cell cycle arrest (GO:0071850)2.67704522
125antigen receptor-mediated signaling pathway (GO:0050851)2.67585095
126sarcomere organization (GO:0045214)2.67217799
127potassium ion import (GO:0010107)2.66838824
128cellular response to type I interferon (GO:0071357)2.66447086
129type I interferon signaling pathway (GO:0060337)2.66447086
130positive regulation of gluconeogenesis (GO:0045722)2.66434320
131interkinetic nuclear migration (GO:0022027)2.66361652
132pinocytosis (GO:0006907)2.66226058
133myeloid cell development (GO:0061515)2.65860723
134sodium ion export (GO:0071436)2.64935583
135glycogen metabolic process (GO:0005977)2.64131883
136negative regulation of stress fiber assembly (GO:0051497)2.64100111
137cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63572689
138myeloid dendritic cell activation (GO:0001773)2.63213820
139positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.63012887
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62610393
141cardiac muscle hypertrophy in response to stress (GO:0014898)2.60897757
142muscle hypertrophy in response to stress (GO:0003299)2.60897757
143cardiac muscle adaptation (GO:0014887)2.60897757
144negative regulation of calcium ion transmembrane transport (GO:1903170)2.59724464
145negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.59724464
146regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.59661110
147regulation of sequestering of triglyceride (GO:0010889)2.59463445
148regulation of T cell receptor signaling pathway (GO:0050856)2.59432655
149regulation of germinal center formation (GO:0002634)2.59055025
150relaxation of smooth muscle (GO:0044557)2.58956410
151auditory receptor cell stereocilium organization (GO:0060088)2.58239078
152cellular glucan metabolic process (GO:0006073)2.58130056
153glucan metabolic process (GO:0044042)2.58130056
154negative regulation of glycoprotein biosynthetic process (GO:0010561)2.57983438
155cardiac muscle contraction (GO:0060048)2.57911993
156regulation of sodium ion transmembrane transporter activity (GO:2000649)2.56095216
157response to epinephrine (GO:0071871)2.55883070
158regulation of synapse structural plasticity (GO:0051823)2.55493618
159negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.55406122
160plasma membrane repair (GO:0001778)2.55260765
161relaxation of cardiac muscle (GO:0055119)2.54915662
162lymphoid progenitor cell differentiation (GO:0002320)2.54248043
163germinal center formation (GO:0002467)2.54077856
164NADH metabolic process (GO:0006734)2.53260705
165regulation of cAMP-dependent protein kinase activity (GO:2000479)2.53197279
1662-oxoglutarate metabolic process (GO:0006103)2.51883378
167response to interferon-alpha (GO:0035455)2.51745429
168muscle tissue morphogenesis (GO:0060415)2.49863525
169positive regulation of vasculogenesis (GO:2001214)2.49612161
170regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.49322476
171regulation of type I interferon-mediated signaling pathway (GO:0060338)2.49280265
172negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.49108639
173heparin biosynthetic process (GO:0030210)2.48573998
174heparin metabolic process (GO:0030202)2.48573998
175mannose metabolic process (GO:0006013)2.48046222
176cellular response to electrical stimulus (GO:0071257)2.47961897
177organic cation transport (GO:0015695)2.47595278
178negative regulation of necroptotic process (GO:0060546)2.47472572
179regulation of female receptivity (GO:0045924)2.47231673
180regulation of sodium ion transmembrane transport (GO:1902305)2.47188162
181positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.46846996
182regulation of response to interferon-gamma (GO:0060330)2.45835315
183interferon-gamma-mediated signaling pathway (GO:0060333)2.44005156
184regulation of T cell tolerance induction (GO:0002664)2.43652938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.30053587
2SCL_19346495_ChIP-Seq_HPC-7_Human4.88971646
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.43698885
4GATA1_22025678_ChIP-Seq_K562_Human4.18177589
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.79470356
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.51519275
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.26309278
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25789137
9RUNX_20019798_ChIP-Seq_JUKART_Human3.06827598
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.06450707
11EZH2_22144423_ChIP-Seq_EOC_Human3.01520391
12MYC_22102868_ChIP-Seq_BL_Human2.72077126
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.67579642
14IGF1R_20145208_ChIP-Seq_DFB_Human2.61056952
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44558926
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38292298
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.37554727
18VDR_21846776_ChIP-Seq_THP-1_Human2.36147709
19SPI1_23127762_ChIP-Seq_K562_Human2.32519304
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32232378
21LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.29644909
22GATA1_19941827_ChIP-Seq_MEL_Mouse2.26420712
23MAF_26560356_Chip-Seq_TH1_Human2.26276671
24TCF7_22412390_ChIP-Seq_EML_Mouse2.25793540
25* IRF8_27001747_Chip-Seq_BMDM_Mouse2.21755473
26* MYB_26560356_Chip-Seq_TH2_Human2.17859027
27* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.15909543
28* NOTCH1_21737748_ChIP-Seq_TLL_Human2.14518396
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11707072
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10950755
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09644075
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03855727
33UTX_26944678_Chip-Seq_JUKART_Human2.02934097
34CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02809479
35GATA1_19941826_ChIP-Seq_K562_Human2.01761559
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97276368
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.96671097
38* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95555519
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95498932
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.95493064
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91509389
42SPI1_23547873_ChIP-Seq_NB4_Human1.89342970
43* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.88547889
44VDR_24763502_ChIP-Seq_THP-1_Human1.87325237
45* MYB_26560356_Chip-Seq_TH1_Human1.86232971
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.79403638
47GBX2_23144817_ChIP-Seq_PC3_Human1.77962058
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.77634807
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77151995
50CIITA_25753668_ChIP-Seq_RAJI_Human1.76729665
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74262504
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72781430
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68148286
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66565489
55KDM2B_26808549_Chip-Seq_DND41_Human1.62355031
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61204515
57DROSHA_22980978_ChIP-Seq_HELA_Human1.60930070
58GATA3_27048872_Chip-Seq_THYMUS_Human1.59393654
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57915622
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.55426038
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.54988776
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.54482149
63GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54260935
64GATA2_19941826_ChIP-Seq_K562_Human1.52300589
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.51499643
66* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49251515
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48701116
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47276119
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46485165
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46430920
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43623604
72* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41947064
73* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41879028
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39446738
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34082330
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34069456
77ER_23166858_ChIP-Seq_MCF-7_Human1.32495586
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32309099
79SMAD4_21799915_ChIP-Seq_A2780_Human1.26559578
80* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26315942
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24817746
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.22477174
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21571144
84* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20065183
85FUS_26573619_Chip-Seq_HEK293_Human1.19575942
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19346895
87* PU_27001747_Chip-Seq_BMDM_Mouse1.17811747
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16849990
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16256130
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15949204
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15808073
92MAF_26560356_Chip-Seq_TH2_Human1.15024855
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15008663
94* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14853717
95GATA3_26560356_Chip-Seq_TH2_Human1.13798968
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13105703
97BCL6_27268052_Chip-Seq_Bcells_Human1.12962449
98* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12944892
99* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12691719
100* FLI1_21867929_ChIP-Seq_TH2_Mouse1.12395902
101TAF15_26573619_Chip-Seq_HEK293_Human1.12364831
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.12230678
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11962280
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11642938
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.10161345
106* EZH2_27294783_Chip-Seq_NPCs_Mouse1.10136542
107* ELK3_25401928_ChIP-Seq_HUVEC_Human1.09707838
108* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07123704
109* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05984824
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05535154
111* TCF4_23295773_ChIP-Seq_U87_Human1.05203078
112JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04980991
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04823182
114LXR_22292898_ChIP-Seq_THP-1_Human1.04408693
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03270707
116SOX2_19829295_ChIP-Seq_ESCs_Human1.02861373
117NANOG_19829295_ChIP-Seq_ESCs_Human1.02861373
118RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02395382
119* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02226623
120SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.02060514
121* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01100048
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01017112
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.00541985
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00438417
125* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00266009
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99791018
127* TBX20_22328084_ChIP-Seq_HEART_Mouse0.99575791
128* TBX20_22080862_ChIP-Seq_HEART_Mouse0.99575791
129* CRX_20693478_ChIP-Seq_RETINA_Mouse0.99351436
130* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99218523
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.98022701
132P300_19829295_ChIP-Seq_ESCs_Human0.96540313
133CBP_20019798_ChIP-Seq_JUKART_Human0.96314646
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96314646
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96293871
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.95602598
137SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95460596
138CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95035810
139CDX2_22108803_ChIP-Seq_LS180_Human0.94631018
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.94548564
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94393400
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94141436
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94008397
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92993234
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92207983
146SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91964759
147NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90970138
148VDR_24787735_ChIP-Seq_THP-1_Human0.90560102
149* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89449090
150SOX2_21211035_ChIP-Seq_LN229_Gbm0.89252616
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89242036
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89088073
153CBX2_27304074_Chip-Seq_ESCs_Mouse0.88687577
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.88523312
155JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88381515
156NCOR1_26117541_ChIP-Seq_K562_Human0.88309579
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87960301
158SPI1_20517297_ChIP-Seq_HL60_Human0.87438540
159LXR_22158963_ChIP-Seq_LIVER_Mouse0.87087943
160SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86889679
161TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86619005
162STAT3_23295773_ChIP-Seq_U87_Human0.86396116
163AR_25329375_ChIP-Seq_VCAP_Human0.85542870
164EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85248756
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84859880
166AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84004584
167P53_22387025_ChIP-Seq_ESCs_Mouse0.83996169
168NFE2_27457419_Chip-Seq_LIVER_Mouse0.83828982
169ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83585940
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83533809
171* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83491172
172CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83402612
173RXR_22108803_ChIP-Seq_LS180_Human0.83314207
174AR_21572438_ChIP-Seq_LNCaP_Human0.82181152
175PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82105188
176ZNF274_21170338_ChIP-Seq_K562_Hela0.82012424
177REST_21632747_ChIP-Seq_MESCs_Mouse0.81934012
178VDR_22108803_ChIP-Seq_LS180_Human0.81845874
179* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.81664288
180PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80339950
181HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80334327
182PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78625795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.63196148
2MP0001835_abnormal_antigen_presentation3.16383664
3MP0000685_abnormal_immune_system3.14748778
4MP0004084_abnormal_cardiac_muscle2.86062774
5MP0005671_abnormal_response_to2.79453475
6MP0004510_myositis2.76726890
7MP0002837_dystrophic_cardiac_calcinosis2.61621631
8MP0002396_abnormal_hematopoietic_system2.57671301
9MP0003763_abnormal_thymus_physiology2.48594063
10MP0003183_abnormal_peptide_metabolism2.46820514
11MP0000751_myopathy2.38503702
12MP0000465_gastrointestinal_hemorrhage2.28849963
13MP0000759_abnormal_skeletal_muscle2.25229142
14MP0004215_abnormal_myocardial_fiber2.21805658
15MP0000013_abnormal_adipose_tissue2.21351832
16MP0004808_abnormal_hematopoietic_stem2.21254932
17MP0002009_preneoplasia2.20692397
18MP0004036_abnormal_muscle_relaxation2.18909409
19MP0001800_abnormal_humoral_immune2.16663248
20MP0004130_abnormal_muscle_cell2.15784704
21MP0001790_abnormal_immune_system2.13536019
22MP0005387_immune_system_phenotype2.13536019
23MP0005464_abnormal_platelet_physiology2.13338481
24MP0004270_analgesia2.00662205
25MP0002332_abnormal_exercise_endurance2.00114402
26MP0002398_abnormal_bone_marrow1.95325948
27MP0002452_abnormal_antigen_presenting1.91311088
28MP0002420_abnormal_adaptive_immunity1.88510161
29MP0002166_altered_tumor_susceptibility1.85965074
30MP0001819_abnormal_immune_cell1.85042475
31MP0000749_muscle_degeneration1.83958853
32MP0003646_muscle_fatigue1.81584628
33MP0002723_abnormal_immune_serum1.75779266
34MP0009785_altered_susceptibility_to1.74770006
35MP0005174_abnormal_tail_pigmentation1.71138187
36MP0001873_stomach_inflammation1.70700505
37MP0000689_abnormal_spleen_morphology1.66898211
38MP0000716_abnormal_immune_system1.65891060
39MP0003866_abnormal_defecation1.64449223
40MP0005025_abnormal_response_to1.62986320
41MP0003191_abnormal_cellular_cholesterol1.60956665
42MP0002909_abnormal_adrenal_gland1.60827835
43MP0003045_fibrosis1.59656775
44MP0002971_abnormal_brown_adipose1.58878870
45MP0005000_abnormal_immune_tolerance1.57843290
46MP0002722_abnormal_immune_system1.57367297
47MP0004484_altered_response_of1.56516588
48MP0002638_abnormal_pupillary_reflex1.51682432
49MP0006036_abnormal_mitochondrial_physio1.50482892
50MP0010368_abnormal_lymphatic_system1.44920114
51MP0002419_abnormal_innate_immunity1.44861552
52MP0003828_pulmonary_edema1.43693735
53MP0009780_abnormal_chondrocyte_physiolo1.42582736
54MP0002429_abnormal_blood_cell1.42260076
55MP0005397_hematopoietic_system_phenotyp1.40386796
56MP0001545_abnormal_hematopoietic_system1.40386796
57MP0001853_heart_inflammation1.40258940
58MP0003300_gastrointestinal_ulcer1.39937214
59MP0001984_abnormal_olfaction1.39053739
60MP0000733_abnormal_muscle_development1.37288096
61MP0005058_abnormal_lysosome_morphology1.37137809
62MP0000703_abnormal_thymus_morphology1.36808312
63MP0005330_cardiomyopathy1.35884691
64MP0002106_abnormal_muscle_physiology1.34602663
65MP0003880_abnormal_central_pattern1.34097640
66MP0001661_extended_life_span1.32546796
67MP0005423_abnormal_somatic_nervous1.32044898
68MP0000569_abnormal_digit_pigmentation1.30551771
69MP0010630_abnormal_cardiac_muscle1.29793059
70MP0008569_lethality_at_weaning1.29514947
71MP0002127_abnormal_cardiovascular_syste1.29101013
72MP0001544_abnormal_cardiovascular_syste1.28903814
73MP0005385_cardiovascular_system_phenoty1.28903814
74MP0002876_abnormal_thyroid_physiology1.26039518
75MP0008775_abnormal_heart_ventricle1.25994094
76MP0009278_abnormal_bone_marrow1.25906062
77MP0000750_abnormal_muscle_regeneration1.25726579
78MP0001501_abnormal_sleep_pattern1.25142096
79MP0005075_abnormal_melanosome_morpholog1.23838184
80MP0003567_abnormal_fetal_cardiomyocyte1.23527778
81MP0004233_abnormal_muscle_weight1.23341592
82MP0002972_abnormal_cardiac_muscle1.23063688
83MP0010155_abnormal_intestine_physiology1.21941459
84MP0003656_abnormal_erythrocyte_physiolo1.18563987
85MP0002006_tumorigenesis1.17135973
86MP0002405_respiratory_system_inflammati1.16934630
87MP0004185_abnormal_adipocyte_glucose1.16684845
88MP0002234_abnormal_pharynx_morphology1.16407363
89MP0003724_increased_susceptibility_to1.15077163
90MP0003172_abnormal_lysosome_physiology1.14438781
91MP0005451_abnormal_body_composition1.14402967
92MP0005666_abnormal_adipose_tissue1.14306079
93MP0005670_abnormal_white_adipose1.11750031
94MP0002148_abnormal_hypersensitivity_rea1.08896045
95MP0004087_abnormal_muscle_fiber1.08367768
96MP0002272_abnormal_nervous_system1.08331062
97MP0005535_abnormal_body_temperature1.07450672
98MP0002108_abnormal_muscle_morphology1.06074996
99MP0002095_abnormal_skin_pigmentation1.03402467
100MP0004145_abnormal_muscle_electrophysio1.02852754
101MP0001845_abnormal_inflammatory_respons1.02067084
102MP0005369_muscle_phenotype1.01850709
103MP0005375_adipose_tissue_phenotype1.01727890
104MP0002822_catalepsy1.01451343
105MP0003011_delayed_dark_adaptation1.01282248
106MP0000230_abnormal_systemic_arterial1.00223816
107MP0005266_abnormal_metabolism0.98009570
108MP0006276_abnormal_autonomic_nervous0.97657966
109MP0003137_abnormal_impulse_conducting0.96397306
110MP0001986_abnormal_taste_sensitivity0.96051879
111MP0000343_altered_response_to0.95095151
112MP0005620_abnormal_muscle_contractility0.93963313
113MP0009840_abnormal_foam_cell0.92468457
114MP0004085_abnormal_heartbeat0.91855644
115MP0005646_abnormal_pituitary_gland0.91843070
116MP0008877_abnormal_DNA_methylation0.91811382
117MP0003279_aneurysm0.91801976
118MP0003635_abnormal_synaptic_transmissio0.91620857
119MP0005645_abnormal_hypothalamus_physiol0.91430274
120MP0004947_skin_inflammation0.91011689
121MP0001502_abnormal_circadian_rhythm0.90927965
122MP0000003_abnormal_adipose_tissue0.90234239
123MP0006138_congestive_heart_failure0.90137781
124MP0002269_muscular_atrophy0.87878824
125MP0003436_decreased_susceptibility_to0.87640764
126MP0008995_early_reproductive_senescence0.87323892
127MP0002064_seizures0.86246535
128MP0008961_abnormal_basal_metabolism0.85392696
129MP0001879_abnormal_lymphatic_vessel0.85023327
130MP0002933_joint_inflammation0.84734450
131MP0002078_abnormal_glucose_homeostasis0.84152928
132MP0002734_abnormal_mechanical_nocicepti0.83873855
133MP0003075_altered_response_to0.82360823
134MP0004859_abnormal_synaptic_plasticity0.81432016
135MP0005409_darkened_coat_color0.81352171
136MP0003879_abnormal_hair_cell0.81217063
137MP0001486_abnormal_startle_reflex0.79463944
138MP0001440_abnormal_grooming_behavior0.79295518
139MP0009333_abnormal_splenocyte_physiolog0.77656449
140MP0008469_abnormal_protein_level0.77381955
141MP0001765_abnormal_ion_homeostasis0.75678430
142MP0006054_spinal_hemorrhage0.75605246
143MP0009745_abnormal_behavioral_response0.74595681
144MP0003690_abnormal_glial_cell0.73556745
145MP0000747_muscle_weakness0.73211496
146MP0005165_increased_susceptibility_to0.72534922
147MP0006082_CNS_inflammation0.71277359
148MP0003633_abnormal_nervous_system0.70484726
149MP0010329_abnormal_lipoprotein_level0.68308522
150MP0002063_abnormal_learning/memory/cond0.66521339
151MP0002118_abnormal_lipid_homeostasis0.61512431
152MP0005386_behavior/neurological_phenoty0.60089791
153MP0004924_abnormal_behavior0.60089791
154MP0005167_abnormal_blood-brain_barrier0.59026880
155MP0002138_abnormal_hepatobiliary_system0.57964585
156MP0005220_abnormal_exocrine_pancreas0.56403976
157MP0002067_abnormal_sensory_capabilities0.54824257
158MP0004043_abnormal_pH_regulation0.54563813
159MP0005334_abnormal_fat_pad0.54469213
160MP0005253_abnormal_eye_physiology0.53834958
161MP0005332_abnormal_amino_acid0.53587371
162MP0002229_neurodegeneration0.53568012
163MP0009046_muscle_twitch0.52675389

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.09085176
2Nemaline bodies (HP:0003798)8.91544316
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.62205468
4Type 1 muscle fiber predominance (HP:0003803)6.36772921
5Distal arthrogryposis (HP:0005684)5.47075693
6Rhabdomyolysis (HP:0003201)4.81020071
7Myopathic facies (HP:0002058)4.49112895
8EMG: myopathic abnormalities (HP:0003458)4.40392308
9Muscle fiber splitting (HP:0003555)4.36373507
10Rimmed vacuoles (HP:0003805)4.24075048
11Myositis (HP:0100614)4.19517782
12Asymmetric septal hypertrophy (HP:0001670)4.03834521
13Chronic otitis media (HP:0000389)3.94098546
14Hyporeflexia of lower limbs (HP:0002600)3.89625102
15Ulnar deviation of the wrist (HP:0003049)3.72639889
16Panhypogammaglobulinemia (HP:0003139)3.68938530
17Round ear (HP:0100830)3.64621494
18Elevated erythrocyte sedimentation rate (HP:0003565)3.57310724
19Agammaglobulinemia (HP:0004432)3.50439792
20Recurrent bronchitis (HP:0002837)3.48147088
21Neck muscle weakness (HP:0000467)3.38024753
22Centrally nucleated skeletal muscle fibers (HP:0003687)3.37507200
23Difficulty running (HP:0009046)3.37421214
24Bundle branch block (HP:0011710)3.35021179
25Exercise-induced myalgia (HP:0003738)3.34309891
26Abnormality of skeletal muscle fiber size (HP:0012084)3.25832187
27Frequent falls (HP:0002359)3.24472923
28Orchitis (HP:0100796)3.21723249
29Petechiae (HP:0000967)3.18470098
30Prolonged bleeding time (HP:0003010)3.11646169
31IgM deficiency (HP:0002850)3.08205774
32Retrobulbar optic neuritis (HP:0100654)3.07755624
33Optic neuritis (HP:0100653)3.07755624
34Atrial fibrillation (HP:0005110)3.06574751
35Abnormality of the left ventricular outflow tract (HP:0011103)3.05010694
36Subaortic stenosis (HP:0001682)3.05010694
37Muscle stiffness (HP:0003552)3.02259555
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.00432491
39Absent phalangeal crease (HP:0006109)2.94628538
40Colitis (HP:0002583)2.92939014
41Supraventricular tachycardia (HP:0004755)2.91280580
42Thrombocytosis (HP:0001894)2.90862119
43Gastrointestinal inflammation (HP:0004386)2.90785959
44Primary atrial arrhythmia (HP:0001692)2.89603024
45Inflammation of the large intestine (HP:0002037)2.87693727
46Hyperkalemia (HP:0002153)2.83440906
47Supraventricular arrhythmia (HP:0005115)2.80947336
48EMG: neuropathic changes (HP:0003445)2.76851707
49Increased variability in muscle fiber diameter (HP:0003557)2.76801605
50Sudden death (HP:0001699)2.76137088
51Gastrointestinal stroma tumor (HP:0100723)2.74412019
52Ventricular tachycardia (HP:0004756)2.71636521
53Generalized muscle weakness (HP:0003324)2.71121710
54Areflexia of lower limbs (HP:0002522)2.68179593
55Facial diplegia (HP:0001349)2.67366409
56Fatigue (HP:0012378)2.65104841
57Abnormality of the fingertips (HP:0001211)2.61232465
58Malignant hyperthermia (HP:0002047)2.53468224
59Calcaneovalgus deformity (HP:0001848)2.51872761
60Calf muscle hypertrophy (HP:0008981)2.50732625
61Fetal akinesia sequence (HP:0001989)2.49821420
62Atrioventricular block (HP:0001678)2.47355715
63Recurrent viral infections (HP:0004429)2.44860111
64Abnormal platelet function (HP:0011869)2.44650701
65Impaired platelet aggregation (HP:0003540)2.44650701
66Arterial thrombosis (HP:0004420)2.44516734
67Recurrent abscess formation (HP:0002722)2.40970017
68B lymphocytopenia (HP:0010976)2.40403556
69Abnormality of B cell number (HP:0010975)2.40403556
70Cellulitis (HP:0100658)2.40216200
71Abnormal finger flexion creases (HP:0006143)2.39841549
72Meningitis (HP:0001287)2.38117641
73Hypoproteinemia (HP:0003075)2.36973140
74Stomach cancer (HP:0012126)2.36633480
75Increased cerebral lipofuscin (HP:0011813)2.36303945
76Abnormality of the nasal mucosa (HP:0000433)2.36169086
77Recurrent fungal infections (HP:0002841)2.36167716
78Chest pain (HP:0100749)2.32702630
79Broad metatarsal (HP:0001783)2.32227453
80Papilledema (HP:0001085)2.29787364
81Eczematoid dermatitis (HP:0000976)2.28587346
82Lipoatrophy (HP:0100578)2.28127566
83Weak cry (HP:0001612)2.26627057
84Heart block (HP:0012722)2.26245268
85Deformed tarsal bones (HP:0008119)2.25072471
86Bulbar palsy (HP:0001283)2.23786037
87Keratoconjunctivitis sicca (HP:0001097)2.23299460
88T lymphocytopenia (HP:0005403)2.20512850
89Spinal canal stenosis (HP:0003416)2.19558400
90Abnormality of T cells (HP:0002843)2.15975609
91Increased IgE level (HP:0003212)2.14806993
92Muscle hypertrophy of the lower extremities (HP:0008968)2.12155175
93Chronic mucocutaneous candidiasis (HP:0002728)2.09775708
94Recurrent cutaneous fungal infections (HP:0011370)2.09775708
95Distal lower limb muscle weakness (HP:0009053)2.07873421
96Encephalitis (HP:0002383)2.07448644
97Chronic diarrhea (HP:0002028)2.05081685
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.04182930
99Nonprogressive disorder (HP:0003680)2.03970439
100Thyroiditis (HP:0100646)2.03341637
101Ventricular fibrillation (HP:0001663)2.03218161
102Reduced subcutaneous adipose tissue (HP:0003758)2.02885612
103Insulin-resistant diabetes mellitus (HP:0000831)2.02570492
104Hyperphosphatemia (HP:0002905)2.02562229
105Dysostosis multiplex (HP:0000943)2.02231724
106Epistaxis (HP:0000421)2.01803832
107Palpitations (HP:0001962)2.01728491
108Gowers sign (HP:0003391)2.01204070
109Chronic sinusitis (HP:0011109)2.00812873
110Spontaneous hematomas (HP:0007420)2.00608163
111Keratoconjunctivitis (HP:0001096)1.99702518
112Abnormal EKG (HP:0003115)1.99260986
113Abnormality of T cell number (HP:0011839)1.98643630
114Dysmetric saccades (HP:0000641)1.98289051
115Febrile seizures (HP:0002373)1.97757056
116Dilated cardiomyopathy (HP:0001644)1.95960670
117Focal motor seizures (HP:0011153)1.94335213
118Amaurosis fugax (HP:0100576)1.93687574
119Lymphopenia (HP:0001888)1.93050018
120Growth hormone excess (HP:0000845)1.92044604
121Exercise-induced muscle cramps (HP:0003710)1.91467024
122Nasal polyposis (HP:0100582)1.90942596
123Type 2 muscle fiber atrophy (HP:0003554)1.90941697
124Abnormal atrioventricular conduction (HP:0005150)1.90816078
125Scapular winging (HP:0003691)1.90127245
126Increased connective tissue (HP:0009025)1.90075904
127Syncope (HP:0001279)1.88877102
128Metaphyseal dysplasia (HP:0100255)1.88457508
129Acute lymphatic leukemia (HP:0006721)1.88445274
130Abnormality of T cell physiology (HP:0011840)1.87853066
131Myoglobinuria (HP:0002913)1.87337488
132Prolonged QT interval (HP:0001657)1.87091860
133Myotonia (HP:0002486)1.87084141
134Vacuolated lymphocytes (HP:0001922)1.87061230
135Fatigable weakness (HP:0003473)1.86321587
136Abnormality of the neuromuscular junction (HP:0003398)1.86321587
137Muscle fiber atrophy (HP:0100295)1.85028722
138Enlarged penis (HP:0000040)1.84224525
139Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82329444
140IgG deficiency (HP:0004315)1.82197242
141Striae distensae (HP:0001065)1.82192167
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.81583179
143Vertigo (HP:0002321)1.81284719
144Systemic lupus erythematosus (HP:0002725)1.80465596
145Loss of speech (HP:0002371)1.79143748
146Hyperinsulinemic hypoglycemia (HP:0000825)1.78564196
147Abnormality of the endocardium (HP:0004306)1.78218011
148Abnormality of the calf musculature (HP:0001430)1.77924845
149Ventricular arrhythmia (HP:0004308)1.75862722
150Abnormality of potassium homeostasis (HP:0011042)1.75664166
151Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.73218992
152Renal cortical cysts (HP:0000803)1.69110456
153Ketoacidosis (HP:0001993)1.68933049
154Abnormality of the foot musculature (HP:0001436)1.68250692
155Waddling gait (HP:0002515)1.66587292
156Oligomenorrhea (HP:0000876)1.65788938
157Muscular dystrophy (HP:0003560)1.65204421
158Increased intramyocellular lipid droplets (HP:0012240)1.61114895
159Ankle clonus (HP:0011448)1.59849764
160Visual hallucinations (HP:0002367)1.59380826
161Increased muscle lipid content (HP:0009058)1.59211829
162Left ventricular hypertrophy (HP:0001712)1.58229079
163Abnormality of fatty-acid metabolism (HP:0004359)1.58133864
164Long clavicles (HP:0000890)1.54168753
165Proximal amyotrophy (HP:0007126)1.51579653
166Abnormality of the shoulder girdle musculature (HP:0001435)1.49231538
167Hip contracture (HP:0003273)1.48893433
168Hyperglycemia (HP:0003074)1.48772216
169Foot dorsiflexor weakness (HP:0009027)1.48483915
170Hypokalemia (HP:0002900)1.46497297
171Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.43433492
172Abnormality of alanine metabolism (HP:0010916)1.43433492
173Hyperalaninemia (HP:0003348)1.43433492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.13853088
2KIT3.03310978
3FLT32.99775693
4MAP4K12.94771422
5TNIK2.86529224
6ZAP702.37879940
7TAOK32.25057297
8INSRR2.20155486
9CSF1R2.10342994
10MAP2K32.01656426
11MUSK1.99664014
12BTK1.97071281
13TYK21.96662858
14TXK1.92711238
15PIK3CG1.90151325
16SYK1.88912713
17DAPK21.87160544
18TTN1.83851586
19PKN21.81470831
20EEF2K1.80734924
21MAP2K21.79176904
22PINK11.69789260
23TEC1.62245422
24CDK191.60824497
25CAMKK21.57477538
26JAK11.55935643
27TIE11.55048356
28SIK21.47918409
29LMTK21.36190912
30RIPK11.32565743
31TGFBR11.31328735
32FES1.28923084
33NME21.28915953
34IRAK41.28181929
35ITK1.26564091
36MYLK1.26115936
37JAK31.24261915
38LCK1.21476097
39CAMK11.20467035
40MAP3K131.16332704
41MAP2K41.15994692
42TBK11.12530776
43HCK1.12288650
44MAPK121.06740931
45SGK4941.04970022
46SGK2231.04970022
47GRK61.03814033
48MAP3K71.03776929
49PRKCH1.01884217
50ERN11.00525029
51IKBKE0.99582668
52HIPK20.99437569
53NLK0.98087507
54CAMKK10.97081275
55GRK70.96046047
56MAP2K60.95279090
57MATK0.92760899
58KDR0.89709051
59BMPR1B0.88506011
60PHKG20.88213060
61PHKG10.88213060
62CAMK40.86499101
63STK380.85694263
64CCNB10.85629256
65CDK60.82113887
66MAP3K120.81939102
67ERBB30.81686897
68IRAK30.81158009
69WNK10.79738745
70PRKAA20.79454723
71PDK10.79271430
72ADRBK20.78317999
73LYN0.78215160
74STK160.77336899
75KSR20.77171925
76SGK10.77148310
77SCYL20.75605855
78CAMK1G0.74641685
79CAMK1D0.74491836
80LRRK20.74391173
81TRIB30.72769010
82RIPK40.70318799
83MAPK150.69519779
84RPS6KB10.69421089
85PLK20.69137751
86DMPK0.68284429
87PRKAA10.67438167
88NME10.67270182
89MAPKAPK50.66793531
90MAP3K140.66527489
91DAPK10.66073769
92PIK3CA0.64910742
93MAPKAPK30.63568818
94PDPK10.62960397
95MAP2K10.62524221
96MAPK110.61000522
97TNK20.60612339
98TRPM70.60229192
99STK240.60103647
100DYRK1A0.59343953
101FRK0.58836006
102BCKDK0.58144196
103PDK20.56361671
104PRKD20.56238258
105CLK10.56166049
106JAK20.55758260
107MAPK70.55624662
108UHMK10.55207828
109NEK60.55129373
110OBSCN0.54233844
111STK100.53873510
112RPS6KC10.53269378
113RPS6KL10.53269378
114SIK30.52876161
115AKT30.52542253
116PRKG10.52433298
117STK110.52388300
118MAPK130.51443438
119NTRK30.51181349
120WNK40.51043668
121RPS6KA60.47942273
122SGK20.46649320
123RAF10.45873105
124MOS0.45230503
125CDK30.44837377
126DYRK1B0.44802443
127SGK30.43946875
128IKBKB0.43930358
129PIM10.43650602
130BRD40.42628971
131CAMK2A0.40489337
132RPS6KA30.40467742
133MARK20.40354150
134CAMK2G0.40027863
135RPS6KA10.40022203
136MAP3K100.39726744
137RPS6KA20.39344848
138MAP3K10.38874858
139MAP3K60.38846163
140PRKD10.38743782
141RET0.38267099
142CHUK0.37182307
143FGFR30.36859582
144YES10.36806525
145BMPR20.35531455
146PDGFRA0.35320077
147PRKACA0.34229211
148MAPK40.33677478

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.70946978
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92116070
3B cell receptor signaling pathway_Homo sapiens_hsa046622.47768753
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04584064
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.96363287
6Osteoclast differentiation_Homo sapiens_hsa043801.94854352
7Dilated cardiomyopathy_Homo sapiens_hsa054141.86029728
8Other glycan degradation_Homo sapiens_hsa005111.78811108
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76977981
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71890094
11Platelet activation_Homo sapiens_hsa046111.71725122
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71441923
13Hematopoietic cell lineage_Homo sapiens_hsa046401.61832525
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.60626975
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.53069384
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50299900
17Antigen processing and presentation_Homo sapiens_hsa046121.47542315
18Regulation of autophagy_Homo sapiens_hsa041401.46912001
19Arginine and proline metabolism_Homo sapiens_hsa003301.46527760
20Leishmaniasis_Homo sapiens_hsa051401.46459965
21T cell receptor signaling pathway_Homo sapiens_hsa046601.44878495
22Peroxisome_Homo sapiens_hsa041461.43850522
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43521106
24Nitrogen metabolism_Homo sapiens_hsa009101.43521024
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42754396
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42318681
27Circadian entrainment_Homo sapiens_hsa047131.38565828
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37754288
29Renin secretion_Homo sapiens_hsa049241.37200579
30Measles_Homo sapiens_hsa051621.31476354
31Calcium signaling pathway_Homo sapiens_hsa040201.30536502
32Fatty acid degradation_Homo sapiens_hsa000711.26716186
33Olfactory transduction_Homo sapiens_hsa047401.25278462
34Propanoate metabolism_Homo sapiens_hsa006401.24985695
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21993207
36Long-term potentiation_Homo sapiens_hsa047201.21277239
37Oxytocin signaling pathway_Homo sapiens_hsa049211.20451268
38Arginine biosynthesis_Homo sapiens_hsa002201.20400045
39Caffeine metabolism_Homo sapiens_hsa002321.19575515
40Gastric acid secretion_Homo sapiens_hsa049711.18992999
41Insulin secretion_Homo sapiens_hsa049111.18029830
42Long-term depression_Homo sapiens_hsa047301.17465401
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17271836
44Dorso-ventral axis formation_Homo sapiens_hsa043201.15735448
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14963635
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11033942
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.10249243
48Salivary secretion_Homo sapiens_hsa049701.09150101
49Phenylalanine metabolism_Homo sapiens_hsa003601.08385231
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07115669
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07089127
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04047041
53Acute myeloid leukemia_Homo sapiens_hsa052211.02573276
54Circadian rhythm_Homo sapiens_hsa047101.02520907
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02381035
56Inositol phosphate metabolism_Homo sapiens_hsa005621.00564401
57Insulin resistance_Homo sapiens_hsa049310.99855141
58Morphine addiction_Homo sapiens_hsa050320.99187330
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97395521
60Fatty acid metabolism_Homo sapiens_hsa012120.96993563
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.95232181
62cAMP signaling pathway_Homo sapiens_hsa040240.94958455
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94317383
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.94057862
65Chemokine signaling pathway_Homo sapiens_hsa040620.93120621
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92989668
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91955761
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.90360223
69Lysosome_Homo sapiens_hsa041420.89348171
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89334114
71Pancreatic secretion_Homo sapiens_hsa049720.88503937
72Herpes simplex infection_Homo sapiens_hsa051680.88494155
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85198685
74Toxoplasmosis_Homo sapiens_hsa051450.84362816
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84041186
76Butanoate metabolism_Homo sapiens_hsa006500.81341298
77Glucagon signaling pathway_Homo sapiens_hsa049220.79575934
78Amphetamine addiction_Homo sapiens_hsa050310.79346332
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79122601
80Type II diabetes mellitus_Homo sapiens_hsa049300.79091739
81Viral myocarditis_Homo sapiens_hsa054160.78975034
82Linoleic acid metabolism_Homo sapiens_hsa005910.78558260
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.77202677
84Tuberculosis_Homo sapiens_hsa051520.75996019
85FoxO signaling pathway_Homo sapiens_hsa040680.75974418
86Serotonergic synapse_Homo sapiens_hsa047260.75399001
87Cardiac muscle contraction_Homo sapiens_hsa042600.75287407
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74983649
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74030712
90Autoimmune thyroid disease_Homo sapiens_hsa053200.73964723
91VEGF signaling pathway_Homo sapiens_hsa043700.73924036
92Glutamatergic synapse_Homo sapiens_hsa047240.73793029
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72930571
94Taste transduction_Homo sapiens_hsa047420.72708104
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72492726
96Cholinergic synapse_Homo sapiens_hsa047250.71453694
97Influenza A_Homo sapiens_hsa051640.70980559
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.70912388
99Ovarian steroidogenesis_Homo sapiens_hsa049130.68811769
100Pertussis_Homo sapiens_hsa051330.68331354
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68201829
102MAPK signaling pathway_Homo sapiens_hsa040100.67305792
103GnRH signaling pathway_Homo sapiens_hsa049120.66160499
104Histidine metabolism_Homo sapiens_hsa003400.65783757
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65020685
106AMPK signaling pathway_Homo sapiens_hsa041520.65009103
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.64829145
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.64073170
109Synaptic vesicle cycle_Homo sapiens_hsa047210.64058271
110Type I diabetes mellitus_Homo sapiens_hsa049400.63178906
111ABC transporters_Homo sapiens_hsa020100.62956112
112Insulin signaling pathway_Homo sapiens_hsa049100.62849285
113Phototransduction_Homo sapiens_hsa047440.62196313
114mTOR signaling pathway_Homo sapiens_hsa041500.62073312
115Hepatitis B_Homo sapiens_hsa051610.61527990
116N-Glycan biosynthesis_Homo sapiens_hsa005100.60525756
117Endocytosis_Homo sapiens_hsa041440.59795333
118Retinol metabolism_Homo sapiens_hsa008300.59604248
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.59216998
120Nicotine addiction_Homo sapiens_hsa050330.58990869
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58082367
122HIF-1 signaling pathway_Homo sapiens_hsa040660.57311869
123Shigellosis_Homo sapiens_hsa051310.56689556
124Salmonella infection_Homo sapiens_hsa051320.56302317
125GABAergic synapse_Homo sapiens_hsa047270.55824077
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55540263
127Allograft rejection_Homo sapiens_hsa053300.54979669
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54455497
129Dopaminergic synapse_Homo sapiens_hsa047280.51783536
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51354648
131Thyroid cancer_Homo sapiens_hsa052160.50620622
132Notch signaling pathway_Homo sapiens_hsa043300.50587243
133PPAR signaling pathway_Homo sapiens_hsa033200.50312091
134Rap1 signaling pathway_Homo sapiens_hsa040150.50256908
135Chronic myeloid leukemia_Homo sapiens_hsa052200.49056242
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47674303
137* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45512114
138Tryptophan metabolism_Homo sapiens_hsa003800.42683324
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42566621
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41488323
141Fatty acid elongation_Homo sapiens_hsa000620.40581906
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40382207
143Starch and sucrose metabolism_Homo sapiens_hsa005000.39476952
144Choline metabolism in cancer_Homo sapiens_hsa052310.38993190
145Cocaine addiction_Homo sapiens_hsa050300.38652613

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