SESN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic process involved in female pregnancy (GO:0060136)7.56536798
2transcription from mitochondrial promoter (GO:0006390)7.50204519
3proline metabolic process (GO:0006560)7.44330701
4replication fork processing (GO:0031297)6.85977567
5establishment of apical/basal cell polarity (GO:0035089)6.46021664
6positive regulation of protein homooligomerization (GO:0032464)6.40503794
7regulation of integrin activation (GO:0033623)6.13131266
8L-serine metabolic process (GO:0006563)5.91720273
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.70129330
10DNA deamination (GO:0045006)5.62523748
11establishment or maintenance of monopolar cell polarity (GO:0061339)5.57877700
12establishment of monopolar cell polarity (GO:0061162)5.57877700
13regulation of protein homooligomerization (GO:0032462)5.53975794
14oxidative demethylation (GO:0070989)5.51527981
15Golgi transport vesicle coating (GO:0048200)5.10823245
16COPI coating of Golgi vesicle (GO:0048205)5.10823245
17somatic hypermutation of immunoglobulin genes (GO:0016446)5.07642390
18somatic diversification of immune receptors via somatic mutation (GO:0002566)5.07642390
19intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)5.05243133
20mitotic G1 DNA damage checkpoint (GO:0031571)4.95521065
21DNA strand renaturation (GO:0000733)4.92510808
22regulation of translational fidelity (GO:0006450)4.89827684
23poly(A)+ mRNA export from nucleus (GO:0016973)4.67854852
24embryonic placenta development (GO:0001892)4.64145611
25negative regulation of JAK-STAT cascade (GO:0046426)4.56030684
26mitotic G1/S transition checkpoint (GO:0044819)4.44065118
27G1 DNA damage checkpoint (GO:0044783)4.38104073
28mRNA cleavage (GO:0006379)4.29164294
29negative regulation of cell cycle arrest (GO:0071157)4.25580160
30formation of translation preinitiation complex (GO:0001731)4.24332009
31regulation of mammary gland epithelial cell proliferation (GO:0033599)4.23926692
32serine family amino acid biosynthetic process (GO:0009070)4.23846871
33cellular response to ATP (GO:0071318)4.21561070
34spliceosomal tri-snRNP complex assembly (GO:0000244)4.16222660
35viral mRNA export from host cell nucleus (GO:0046784)4.13688339
36negative regulation of fatty acid biosynthetic process (GO:0045717)4.10843446
37histone H4-K12 acetylation (GO:0043983)4.05093323
38regulation of gene silencing by RNA (GO:0060966)4.04205154
39regulation of posttranscriptional gene silencing (GO:0060147)4.04205154
40regulation of gene silencing by miRNA (GO:0060964)4.04205154
41positive regulation of protein oligomerization (GO:0032461)3.98644293
42negative regulation of Ras GTPase activity (GO:0034261)3.95700818
43glutamine family amino acid biosynthetic process (GO:0009084)3.93231623
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89916597
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89916597
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.89916597
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.87289280
48dosage compensation (GO:0007549)3.84240844
49trophectodermal cell differentiation (GO:0001829)3.83724769
50base-excision repair (GO:0006284)3.80957208
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.80479791
52embryonic camera-type eye development (GO:0031076)3.80423552
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.75846998
54apoptotic process involved in morphogenesis (GO:0060561)3.74455642
55protein localization to endosome (GO:0036010)3.73471213
56regulation of RNA export from nucleus (GO:0046831)3.72488338
57regulation of sister chromatid cohesion (GO:0007063)3.71789780
58convergent extension (GO:0060026)3.70824846
59regulation of early endosome to late endosome transport (GO:2000641)3.68714000
60negative regulation of protein oligomerization (GO:0032460)3.65250245
61nodal signaling pathway (GO:0038092)3.65196889
62regulation of protein oligomerization (GO:0032459)3.64546233
63retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.64378063
64DNA integration (GO:0015074)3.63166430
65cellular protein complex localization (GO:0034629)3.62033761
66positive regulation of developmental pigmentation (GO:0048087)3.56234099
67regulation of chromatin binding (GO:0035561)3.56227417
68positive regulation by host of viral transcription (GO:0043923)3.51403888
69regulation of hippo signaling (GO:0035330)3.50785572
70face development (GO:0060324)3.44937304
71meiotic chromosome segregation (GO:0045132)3.42012237
72negative regulation of mRNA processing (GO:0050686)3.41374199
73telomere maintenance via semi-conservative replication (GO:0032201)3.41040157
74mitotic chromosome condensation (GO:0007076)3.39741752
75non-recombinational repair (GO:0000726)3.37779310
76double-strand break repair via nonhomologous end joining (GO:0006303)3.37779310
77activation of MAPKKK activity (GO:0000185)3.36558162
78activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.36003794
79anatomical structure regression (GO:0060033)3.35693752
80mitochondrial RNA metabolic process (GO:0000959)3.34164931
81labyrinthine layer development (GO:0060711)3.33551496
82positive regulation of nuclease activity (GO:0032075)3.30894537
83DNA double-strand break processing (GO:0000729)3.29054350
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.25814662
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.25429309
86activation of Rac GTPase activity (GO:0032863)3.25078613
87regulation of apoptotic process involved in morphogenesis (GO:1902337)3.24612632
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23210156
89regulation of double-strand break repair (GO:2000779)3.22794055
90glial cell migration (GO:0008347)3.21585158
91endoplasmic reticulum unfolded protein response (GO:0030968)3.18713866
92anterior/posterior axis specification, embryo (GO:0008595)3.18060146
93termination of RNA polymerase II transcription (GO:0006369)3.17868458
94maturation of 5.8S rRNA (GO:0000460)3.17573759
95positive regulation of chromosome segregation (GO:0051984)3.15113393
96cellular response to zinc ion (GO:0071294)3.13751747
97base-excision repair, AP site formation (GO:0006285)3.11985288
98determination of adult lifespan (GO:0008340)3.10909801
99protein complex localization (GO:0031503)3.10567185
100pre-miRNA processing (GO:0031054)3.09872370
101mitotic sister chromatid segregation (GO:0000070)3.08112107
102DNA topological change (GO:0006265)3.07737827
103regulation of DNA damage checkpoint (GO:2000001)3.05559234
104ER-nucleus signaling pathway (GO:0006984)3.05363788
105GDP-mannose metabolic process (GO:0019673)3.05331401
106regulation of cell size (GO:0008361)3.03702584
107regulation of nuclease activity (GO:0032069)3.01371820
108positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.00782158
109tetrahydrofolate metabolic process (GO:0046653)2.98967359
110protein retention in ER lumen (GO:0006621)2.98258559
111cellular response to unfolded protein (GO:0034620)2.97421566
112glucose 6-phosphate metabolic process (GO:0051156)2.97321796
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97019032
114regulation of NFAT protein import into nucleus (GO:0051532)2.97000186
115cellular response to arsenic-containing substance (GO:0071243)2.92066404
116positive regulation of DNA repair (GO:0045739)2.91237162
117regulation of podosome assembly (GO:0071801)2.91019610
118intracellular estrogen receptor signaling pathway (GO:0030520)2.88407541
119regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.87407011
120negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.87215989
121regulation of nucleobase-containing compound transport (GO:0032239)2.86999538
122negative regulation of RNA splicing (GO:0033119)2.86984309
123protein targeting to vacuole (GO:0006623)2.86757179
124protein targeting to lysosome (GO:0006622)2.86757179
125establishment of protein localization to vacuole (GO:0072666)2.86757179
1263-UTR-mediated mRNA stabilization (GO:0070935)2.86522268
127ribosomal small subunit biogenesis (GO:0042274)2.86413994
128pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86287968
129DNA unwinding involved in DNA replication (GO:0006268)2.85576171
130homocysteine metabolic process (GO:0050667)2.83427163
131L-alpha-amino acid transmembrane transport (GO:1902475)2.83286952
132embryonic eye morphogenesis (GO:0048048)2.81327298
133nuclear envelope reassembly (GO:0031468)2.80124133
134cellular response to topologically incorrect protein (GO:0035967)2.79663567
135heterochromatin organization (GO:0070828)2.79214237
136mitochondrial fusion (GO:0008053)2.78894694
137regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.78504276
138regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76678432
139folic acid-containing compound biosynthetic process (GO:0009396)2.75964427
140adherens junction assembly (GO:0034333)2.74692959
141tRNA aminoacylation for protein translation (GO:0006418)2.74662251
142endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.73125071
143peptidyl-arginine omega-N-methylation (GO:0035247)2.70781303
144response to endoplasmic reticulum stress (GO:0034976)2.66100444
145intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)2.63845060
146response to arsenic-containing substance (GO:0046685)2.63349105
147regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.62264651
148ER overload response (GO:0006983)2.61454089
149amino acid activation (GO:0043038)2.61285467
150tRNA aminoacylation (GO:0043039)2.61285467
151amyloid precursor protein catabolic process (GO:0042987)2.60969493
152regulation of cholesterol homeostasis (GO:2000188)2.59098552
153myeloid cell homeostasis (GO:0002262)2.58799813
154negative regulation of viral release from host cell (GO:1902187)2.57722558
155intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.57087019
156mannose metabolic process (GO:0006013)2.56560152
157protein maturation by protein folding (GO:0022417)2.56503966
158regulation of translational termination (GO:0006449)2.56120672
159serine transport (GO:0032329)2.54622594
160DNA replication initiation (GO:0006270)2.52373655
161lymph vessel development (GO:0001945)2.51024979
162negative regulation of erythrocyte differentiation (GO:0045647)2.50742048
163protein localization to chromosome, centromeric region (GO:0071459)2.50604392
164trophoblast giant cell differentiation (GO:0060707)2.50436397
165vesicle coating (GO:0006901)2.47798655
166decidualization (GO:0046697)2.47666042
167positive regulation of p38MAPK cascade (GO:1900745)2.47094850
168cell-substrate adherens junction assembly (GO:0007045)2.46028973
169focal adhesion assembly (GO:0048041)2.46028973
170negative regulation of necroptotic process (GO:0060546)2.46019271
171protein insertion into membrane (GO:0051205)2.43071312
172mitotic nuclear envelope reassembly (GO:0007084)2.41259011
173folic acid-containing compound metabolic process (GO:0006760)2.40783413
174pentose metabolic process (GO:0019321)2.40563701
175NADH metabolic process (GO:0006734)2.40479589
176regulation of response to osmotic stress (GO:0047484)2.39096943
177COPII vesicle coating (GO:0048208)2.38976482
178urea cycle (GO:0000050)2.36936728
179rRNA transcription (GO:0009303)2.36918912
180tooth mineralization (GO:0034505)2.36827772
181modulation by symbiont of host cellular process (GO:0044068)2.35274328
182proline biosynthetic process (GO:0006561)10.0053140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.62773745
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.62773745
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.62773745
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.44507801
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.22738175
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.71145764
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.69548654
8E2F7_22180533_ChIP-Seq_HELA_Human2.69484601
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.63841031
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.45852684
11* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.42818943
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34708980
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.33730129
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.29019385
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27064690
16KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.26125790
17VDR_21846776_ChIP-Seq_THP-1_Human2.19659938
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18821960
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.16679779
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.15157166
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11539605
22* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.08350575
23* POU5F1_16518401_ChIP-PET_MESCs_Mouse2.04282427
24STAT3_1855785_ChIP-Seq_MESCs_Mouse2.03797073
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03531137
26TCF3_18692474_ChIP-Seq_MEFs_Mouse2.03443824
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97021653
28* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93399507
29* XRN2_22483619_ChIP-Seq_HELA_Human1.90625802
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85093434
31* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.85044879
32* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83215463
33LXR_22292898_ChIP-Seq_THP-1_Human1.79019682
34NANOG_21062744_ChIP-ChIP_HESCs_Human1.77782148
35MYC_22102868_ChIP-Seq_BL_Human1.76496707
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75173813
37* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70157306
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66152225
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66113008
40* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.66093202
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64852073
42ZNF263_19887448_ChIP-Seq_K562_Human1.63071582
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57603367
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56471480
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.55373791
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50795380
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.48951811
48RACK7_27058665_Chip-Seq_MCF-7_Human1.48064470
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47522580
50* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47204540
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46763486
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46581320
53NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.45827261
54NCOR1_26117541_ChIP-Seq_K562_Human1.44121741
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42427653
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42268201
57TCF7_22412390_ChIP-Seq_EML_Mouse1.40531062
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40528708
59* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.39994352
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39219763
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38396825
62* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37416154
63DCP1A_22483619_ChIP-Seq_HELA_Human1.36920591
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36103502
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35821519
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35210048
67* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34348468
68* KDM2B_26808549_Chip-Seq_K562_Human1.34335108
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.32894884
70* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.31497989
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31314065
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31201165
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30230337
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30074744
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29956795
76* TP53_22127205_ChIP-Seq_IMR90_Human1.29725109
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.29445267
78* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28929879
79* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28759263
80* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27642554
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26916342
82* SA1_27219007_Chip-Seq_ERYTHROID_Human1.25582289
83* KDM2B_26808549_Chip-Seq_DND41_Human1.24762803
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24758919
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23662506
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23335687
87* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22868244
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22786487
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.21998276
90OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21462063
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19447961
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.19036231
93CLOCK_20551151_ChIP-Seq_293T_Human1.18853165
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18847048
95TTF2_22483619_ChIP-Seq_HELA_Human1.18751930
96* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18464486
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17386103
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.17257032
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16982670
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16965429
101* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16551514
102* MAF_26560356_Chip-Seq_TH1_Human1.16131569
103TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15178689
104* ELK3_25401928_ChIP-Seq_HUVEC_Human1.14349161
105P68_20966046_ChIP-Seq_HELA_Human1.14246917
106KDM5A_27292631_Chip-Seq_BREAST_Human1.13209855
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13091742
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12875901
109* MAF_26560356_Chip-Seq_TH2_Human1.10228893
110CREB1_26743006_Chip-Seq_LNCaP_Human1.09805290
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09706536
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08932000
113* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08148728
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07863652
115RARB_24833708_ChIP-Seq_LIVER_Mouse1.07303388
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07191527
117GABP_19822575_ChIP-Seq_HepG2_Human1.06795411
118NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06537796
119RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06276772
120* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05836335
121NANOG_16518401_ChIP-PET_MESCs_Mouse1.05610321
122E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05151569
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.05023099
124HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04953420
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04844612
126ETS1_20019798_ChIP-Seq_JURKAT_Human1.04491618
127* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04089795
128TFEB_21752829_ChIP-Seq_HELA_Human1.03589484
129* ETS1_21867929_ChIP-Seq_TH2_Mouse1.02433805
130ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02299630
131* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02106956
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01974097
133* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01721766
134UBF1/2_26484160_Chip-Seq_HMECs_Human1.01514537
135* KAP1_27257070_Chip-Seq_ESCs_Mouse1.01113176
136CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00314188
137ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99674261
138* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99570944
139* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99316844
140* KDM2B_26808549_Chip-Seq_JURKAT_Human0.99285575
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99254007
142* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98952336
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98332594
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98289740
145ATF3_27146783_Chip-Seq_COLON_Human0.98237881
146TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97459868
147* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97100560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.74857715
2MP0009278_abnormal_bone_marrow4.05560148
3MP0010030_abnormal_orbit_morphology3.80915423
4MP0005171_absent_coat_pigmentation3.59995675
5MP0005451_abnormal_body_composition3.26157937
6MP0009840_abnormal_foam_cell3.16473621
7MP0004233_abnormal_muscle_weight3.14296229
8MP0002009_preneoplasia2.82525333
9MP0003283_abnormal_digestive_organ2.71896294
10MP0003890_abnormal_embryonic-extraembry2.68769676
11MP0008260_abnormal_autophagy2.66979460
12MP0002653_abnormal_ependyma_morphology2.41751230
13MP0008438_abnormal_cutaneous_collagen2.41258828
14MP0000678_abnormal_parathyroid_gland2.40020426
15MP0004133_heterotaxia2.35315267
16MP0010094_abnormal_chromosome_stability2.35237512
17MP0003119_abnormal_digestive_system2.30294679
18MP0010352_gastrointestinal_tract_polyps2.29186421
19MP0008995_early_reproductive_senescence2.28218145
20MP0004957_abnormal_blastocyst_morpholog2.26072943
21MP0005076_abnormal_cell_differentiation2.25593600
22MP0001545_abnormal_hematopoietic_system1.98892859
23MP0005397_hematopoietic_system_phenotyp1.98892859
24MP0003786_premature_aging1.92718290
25MP0003453_abnormal_keratinocyte_physiol1.90283506
26MP0003111_abnormal_nucleus_morphology1.89677721
27MP0002084_abnormal_developmental_patter1.89509814
28MP0002086_abnormal_extraembryonic_tissu1.85101246
29MP0006072_abnormal_retinal_apoptosis1.79574213
30MP0000858_altered_metastatic_potential1.78837906
31MP0002249_abnormal_larynx_morphology1.74545334
32MP0001697_abnormal_embryo_size1.73243163
33MP0004197_abnormal_fetal_growth/weight/1.71271783
34MP0002085_abnormal_embryonic_tissue1.69105949
35MP0003303_peritoneal_inflammation1.68879477
36MP0001293_anophthalmia1.67086658
37MP0001849_ear_inflammation1.66392461
38MP0010234_abnormal_vibrissa_follicle1.61264659
39MP0002282_abnormal_trachea_morphology1.60012383
40MP0008877_abnormal_DNA_methylation1.58603407
41MP0002139_abnormal_hepatobiliary_system1.55950153
42MP0004858_abnormal_nervous_system1.54875618
43MP0004272_abnormal_basement_membrane1.54471197
44MP0005380_embryogenesis_phenotype1.54108186
45MP0001672_abnormal_embryogenesis/_devel1.54108186
46MP0008058_abnormal_DNA_repair1.53200962
47MP0008932_abnormal_embryonic_tissue1.53079329
48MP0003077_abnormal_cell_cycle1.51504877
49MP0002254_reproductive_system_inflammat1.49149914
50MP0003172_abnormal_lysosome_physiology1.43460630
51MP0005174_abnormal_tail_pigmentation1.40110684
52MP0000537_abnormal_urethra_morphology1.39955655
53MP0003656_abnormal_erythrocyte_physiolo1.39591846
54MP0004264_abnormal_extraembryonic_tissu1.37608770
55MP0001730_embryonic_growth_arrest1.36486669
56MP0009333_abnormal_splenocyte_physiolog1.35651222
57MP0000490_abnormal_crypts_of1.35241250
58MP0000371_diluted_coat_color1.33907661
59MP0003693_abnormal_embryo_hatching1.33395231
60MP0000003_abnormal_adipose_tissue1.33055438
61MP0003567_abnormal_fetal_cardiomyocyte1.32942143
62MP0003705_abnormal_hypodermis_morpholog1.31028356
63MP0002111_abnormal_tail_morphology1.29625296
64MP0002089_abnormal_postnatal_growth/wei1.29257423
65MP0003436_decreased_susceptibility_to1.28890414
66MP0010307_abnormal_tumor_latency1.26633786
67* MP0000350_abnormal_cell_proliferation1.23505754
68MP0000579_abnormal_nail_morphology1.23156120
69MP0000462_abnormal_digestive_system1.23002355
70MP0003984_embryonic_growth_retardation1.23001289
71MP0002269_muscular_atrophy1.20958323
72MP0002796_impaired_skin_barrier1.19635142
73MP0002088_abnormal_embryonic_growth/wei1.18977777
74MP0005058_abnormal_lysosome_morphology1.18603609
75MP0000470_abnormal_stomach_morphology1.18349410
76MP0004782_abnormal_surfactant_physiolog1.17399486
77MP0008007_abnormal_cellular_replicative1.16862755
78MP0002080_prenatal_lethality1.16084235
79MP0001216_abnormal_epidermal_layer1.14700067
80MP0001346_abnormal_lacrimal_gland1.11010918
81MP0004947_skin_inflammation1.09878978
82MP0005621_abnormal_cell_physiology1.08428169
83MP0005257_abnormal_intraocular_pressure1.07694761
84MP0009672_abnormal_birth_weight1.07191608
85MP0000733_abnormal_muscle_development1.06597832
86MP0005375_adipose_tissue_phenotype1.06322442
87MP0002932_abnormal_joint_morphology1.04778361
88MP0009931_abnormal_skin_appearance1.04445775
89MP0001340_abnormal_eyelid_morphology1.04409091
90MP0003191_abnormal_cellular_cholesterol1.03486611
91MP0003566_abnormal_cell_adhesion1.03062498
92MP0003329_amyloid_beta_deposits1.03009233
93MP0003755_abnormal_palate_morphology1.02199094
94MP0000639_abnormal_adrenal_gland1.01469907
95MP0004510_myositis1.01291765
96MP0003935_abnormal_craniofacial_develop1.01265060
97MP0002098_abnormal_vibrissa_morphology1.01020584
98MP0003045_fibrosis0.97904156
99MP0003091_abnormal_cell_migration0.97118015
100MP0000762_abnormal_tongue_morphology0.96200294
101MP0001915_intracranial_hemorrhage0.95877500
102MP0002019_abnormal_tumor_incidence0.95815444
103MP0003828_pulmonary_edema0.95713319
104MP0003942_abnormal_urinary_system0.94948191
105MP0000432_abnormal_head_morphology0.92660019
106MP0005367_renal/urinary_system_phenotyp0.91404627
107MP0000516_abnormal_urinary_system0.91404627
108MP0005501_abnormal_skin_physiology0.91317544
109MP0005075_abnormal_melanosome_morpholog0.91064829
110MP0009053_abnormal_anal_canal0.90938520
111MP0003941_abnormal_skin_development0.90435941
112MP0002060_abnormal_skin_morphology0.89548964
113MP0002114_abnormal_axial_skeleton0.89166322
114MP0002877_abnormal_melanocyte_morpholog0.88282147
115MP0005384_cellular_phenotype0.87993847
116MP0005023_abnormal_wound_healing0.87575504
117MP0005508_abnormal_skeleton_morphology0.87388353
118MP0005666_abnormal_adipose_tissue0.86711286
119MP0003300_gastrointestinal_ulcer0.86285344
120MP0000015_abnormal_ear_pigmentation0.85795203
121MP0010771_integument_phenotype0.85560122
122MP0002116_abnormal_craniofacial_bone0.84398096
123MP0009115_abnormal_fat_cell0.83154851
124MP0005266_abnormal_metabolism0.82330824
125MP0003718_maternal_effect0.79457362
126MP0002075_abnormal_coat/hair_pigmentati0.78310033
127MP0003186_abnormal_redox_activity0.76017325
128MP0000377_abnormal_hair_follicle0.75375851
129MP0001661_extended_life_span0.74676488
130MP0005360_urolithiasis0.74455331
131MP0001145_abnormal_male_reproductive0.74333444
132MP0000467_abnormal_esophagus_morphology0.72982667
133MP0002697_abnormal_eye_size0.72550894
134MP0004185_abnormal_adipocyte_glucose0.72130284
135MP0002092_abnormal_eye_morphology0.70682403
136MP0002332_abnormal_exercise_endurance0.69985953
137MP0003115_abnormal_respiratory_system0.69914217
138* MP0000313_abnormal_cell_death0.69018457
139MP0000358_abnormal_cell_content/0.67838792
140MP0000609_abnormal_liver_physiology0.66915806
141MP0003221_abnormal_cardiomyocyte_apopto0.66452940
142MP0003936_abnormal_reproductive_system0.66440937
143MP0003385_abnormal_body_wall0.66294891
144MP0001186_pigmentation_phenotype0.64886035
145MP0010630_abnormal_cardiac_muscle0.62814031
146MP0002925_abnormal_cardiovascular_devel0.62436414
147MP0000477_abnormal_intestine_morphology0.61620097
148MP0001784_abnormal_fluid_regulation0.61076803
149MP0002970_abnormal_white_adipose0.61026261
150MP0005623_abnormal_meninges_morphology0.59662244

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.78452043
2Facial hemangioma (HP:0000329)4.85815669
3Concave nail (HP:0001598)4.80634650
4Rectal fistula (HP:0100590)4.59422158
5Rectovaginal fistula (HP:0000143)4.59422158
6Annular pancreas (HP:0001734)4.52071943
7Pustule (HP:0200039)4.41996242
8Ulnar bowing (HP:0003031)4.34545351
9Turricephaly (HP:0000262)4.33663906
10Hypochromic microcytic anemia (HP:0004840)4.26831462
11Alopecia of scalp (HP:0002293)4.20225410
12Intestinal fistula (HP:0100819)4.19439290
13Vaginal fistula (HP:0004320)4.14670568
14Short humerus (HP:0005792)4.11761263
15Increased IgM level (HP:0003496)4.05453272
16Poikiloderma (HP:0001029)4.00454003
17Aplasia/hypoplasia of the humerus (HP:0006507)3.96876398
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.91944907
19Tongue fasciculations (HP:0001308)3.83887338
20Coronal craniosynostosis (HP:0004440)3.62876697
21Male infertility (HP:0003251)3.60196261
22Muscle fibrillation (HP:0010546)3.59311365
23Orthostatic hypotension (HP:0001278)3.50907033
24Vertebral hypoplasia (HP:0008417)3.48141606
25Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.48141606
26Abnormal hemoglobin (HP:0011902)3.40995231
27Absent radius (HP:0003974)3.32351663
28Intestinal atresia (HP:0011100)3.28516115
29Upper limb muscle weakness (HP:0003484)3.27779171
30Abnormal gallbladder physiology (HP:0012438)3.20441270
31Cholecystitis (HP:0001082)3.20441270
32Absent forearm bone (HP:0003953)3.12413959
33Aplasia involving forearm bones (HP:0009822)3.12413959
34Long palpebral fissure (HP:0000637)3.09288316
35Truncus arteriosus (HP:0001660)3.04008098
36Congenital hip dislocation (HP:0001374)3.02383266
37Anteriorly placed anus (HP:0001545)2.99627978
38Premature rupture of membranes (HP:0001788)2.94564268
39Squamous cell carcinoma (HP:0002860)2.92987013
40Dysautonomia (HP:0002459)2.92482424
41Urinary glycosaminoglycan excretion (HP:0003541)2.89714209
42Mucopolysacchariduria (HP:0008155)2.89714209
43Protrusio acetabuli (HP:0003179)2.89292131
44Alacrima (HP:0000522)2.82470724
45Broad alveolar ridges (HP:0000187)2.82309654
46Cerebral aneurysm (HP:0004944)2.82269094
47Abnormality of male internal genitalia (HP:0000022)2.81778163
48Selective tooth agenesis (HP:0001592)2.80639281
49Vertebral compression fractures (HP:0002953)2.79706067
50Absent thumb (HP:0009777)2.76970513
51Short chin (HP:0000331)2.76034090
52Basal cell carcinoma (HP:0002671)2.74344359
53Distal upper limb amyotrophy (HP:0007149)2.73808743
54Upper limb amyotrophy (HP:0009129)2.73808743
55Large for gestational age (HP:0001520)2.70797461
56Abnormality of the aortic arch (HP:0012303)2.67667518
57Septate vagina (HP:0001153)2.67601597
58Hyperacusis (HP:0010780)2.65393366
59Abnormality of the astrocytes (HP:0100707)2.63258247
60Astrocytoma (HP:0009592)2.63258247
61Hand muscle atrophy (HP:0009130)2.61407254
62Abnormality of polysaccharide metabolism (HP:0011012)2.60287608
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60287608
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60287608
65Pancreatic islet-cell hyperplasia (HP:0004510)2.59104626
66Abnormality of the labia minora (HP:0012880)2.58919558
67Diaphragmatic weakness (HP:0009113)2.58600508
68Premature skin wrinkling (HP:0100678)2.58522820
69Vertebral fusion (HP:0002948)2.58487970
70Patellar aplasia (HP:0006443)2.58427062
71Abnormality of nail color (HP:0100643)2.58300268
72Dysostosis multiplex (HP:0000943)2.55774131
73Abnormal umbilical cord blood vessels (HP:0011403)2.54437644
74Single umbilical artery (HP:0001195)2.54437644
75Abnormality of the fetal cardiovascular system (HP:0010948)2.54437644
76Reticulocytosis (HP:0001923)2.52603533
77Hypotrichosis (HP:0001006)2.49950693
78Volvulus (HP:0002580)2.49361165
79Albinism (HP:0001022)2.48895561
80Bowed forearm bones (HP:0003956)2.47268635
81Bowing of the arm (HP:0006488)2.47268635
82Hamartoma (HP:0010566)2.46810071
83Choanal stenosis (HP:0000452)2.43795790
84Hypertensive crisis (HP:0100735)2.42510503
85Broad distal phalanx of finger (HP:0009836)2.42325658
86Hypotelorism (HP:0000601)2.40361177
87Insomnia (HP:0100785)2.40353984
88Joint stiffness (HP:0001387)2.39186965
89Disproportionate tall stature (HP:0001519)2.38107924
90Abnormality of the umbilical cord (HP:0010881)2.37907221
91Genu recurvatum (HP:0002816)2.35336212
92Aplasia/Hypoplasia of the patella (HP:0006498)2.35212684
93Breast hypoplasia (HP:0003187)2.33781963
94Hyperparathyroidism (HP:0000843)2.32465103
95Hypochromic anemia (HP:0001931)2.31861544
96Abnormality of reticulocytes (HP:0004312)2.28966651
97Achilles tendon contracture (HP:0001771)2.28285962
98Abnormal ventriculo-arterial connection (HP:0011563)2.26931237
99Transposition of the great arteries (HP:0001669)2.26931237
100Abnormal connection of the cardiac segments (HP:0011545)2.26931237
101Entropion (HP:0000621)2.26662220
102Capillary hemangiomas (HP:0005306)2.26615628
103Premature graying of hair (HP:0002216)2.26054880
104Clumsiness (HP:0002312)2.23907545
105Polycythemia (HP:0001901)2.22793705
106Aplasia of the musculature (HP:0100854)2.22703135
107Neoplasm of the oral cavity (HP:0100649)2.22356064
108Growth hormone excess (HP:0000845)2.21741530
109Bifid uvula (HP:0000193)2.20476845
110Spinal muscular atrophy (HP:0007269)2.20332425
111Progressive muscle weakness (HP:0003323)2.15900002
112Abnormality of the Achilles tendon (HP:0005109)2.15795479
113Increased number of teeth (HP:0011069)2.15667050
114Gastrointestinal atresia (HP:0002589)2.15214261
115Abnormality of the lower motor neuron (HP:0002366)2.14901241
116Split hand (HP:0001171)2.14307298
117Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14207797
118Biconcave vertebral bodies (HP:0004586)2.12390399
119Hypercortisolism (HP:0001578)2.11888811
120Decreased lacrimation (HP:0000633)2.10846377
121Ependymoma (HP:0002888)2.09799559
122Shawl scrotum (HP:0000049)2.06658890
123Ragged-red muscle fibers (HP:0003200)2.05912383
124Short 5th finger (HP:0009237)2.05821378
125Abnormality of the distal phalanges of the toes (HP:0010182)2.05055302
126Abnormality of the phalanges of the hallux (HP:0010057)2.03366179
127Nonimmune hydrops fetalis (HP:0001790)2.02636339
128Fragile skin (HP:0001030)2.00331950
129Deep palmar crease (HP:0006191)1.99455474
130IgA deficiency (HP:0002720)1.98054626
131Acute lymphatic leukemia (HP:0006721)1.97639523
132Trismus (HP:0000211)1.94743767
133Thin bony cortex (HP:0002753)1.92360679
134Cortical dysplasia (HP:0002539)1.92089445
135Abnormality of the thoracic spine (HP:0100711)1.91932358
136Hypokinesia (HP:0002375)1.91051908
137Metaphyseal cupping (HP:0003021)1.90520597
138Glioma (HP:0009733)1.90414163
139Hemivertebrae (HP:0002937)1.90145969
140Popliteal pterygium (HP:0009756)1.89107031
141Microvesicular hepatic steatosis (HP:0001414)1.86482780
142Narrow nasal bridge (HP:0000446)1.86466585
143Abnormality of the gallbladder (HP:0005264)1.85588787
144Hypoplasia of the radius (HP:0002984)1.85397000
145Natal tooth (HP:0000695)1.85352601
146Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85014765
147Cholelithiasis (HP:0001081)1.83946904
148Congenital malformation of the right heart (HP:0011723)1.83230807
149Double outlet right ventricle (HP:0001719)1.83230807
150Atrophic scars (HP:0001075)1.82520315
151Generalized amyotrophy (HP:0003700)1.82508174
152Missing ribs (HP:0000921)1.82494984
153Amelogenesis imperfecta (HP:0000705)1.80040067
154Hyperthyroidism (HP:0000836)1.79174523
155Reticulocytopenia (HP:0001896)1.79066564
156Patellar dislocation (HP:0002999)1.77340432
157Cervical subluxation (HP:0003308)1.74250418
158Progressive external ophthalmoplegia (HP:0000590)1.74212814
159Long foot (HP:0001833)1.73747941
160Ankle contracture (HP:0006466)1.73456696
161Emphysema (HP:0002097)1.72634896
162Abnormal large intestine physiology (HP:0012700)1.71850603
163Onycholysis (HP:0001806)1.71324701
164Atelectasis (HP:0100750)1.71275826
165Hammertoe (HP:0001765)1.70188434
166Cutaneous melanoma (HP:0012056)1.70016476
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.66984506
168Elbow flexion contracture (HP:0002987)1.66862484
169Bowel incontinence (HP:0002607)1.66720796
170Sparse lateral eyebrow (HP:0005338)1.66552554
171Myocardial infarction (HP:0001658)1.65110620
172Abnormality of the tricuspid valve (HP:0001702)1.64481108
173Ankyloglossia (HP:0010296)1.63821347
174Stridor (HP:0010307)1.62803320
175Segmental peripheral demyelination/remyelination (HP:0003481)1.62775940
176Cerebral inclusion bodies (HP:0100314)1.62665821
177Blue sclerae (HP:0000592)1.62073772
178Prolonged neonatal jaundice (HP:0006579)1.60787474
179Hypercalcemia (HP:0003072)1.60627096
180Renal cell carcinoma (HP:0005584)1.58486431
181Abnormality of liposaccharide metabolism (HP:0010968)1.58211891
182Abnormality of glycosphingolipid metabolism (HP:0004343)1.58211891
183Abnormality of glycolipid metabolism (HP:0010969)1.58211891
184Mitral regurgitation (HP:0001653)1.58025062
185Fatigue (HP:0012378)1.57249959
186Bladder diverticulum (HP:0000015)1.56840093
187Patent foramen ovale (HP:0001655)1.56767269
188Multiple lipomas (HP:0001012)1.56725223
189Abnormal gallbladder morphology (HP:0012437)1.55187808
190Large hands (HP:0001176)1.54446317
191Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.54130199
192Abnormalities of placenta or umbilical cord (HP:0001194)1.53567124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.85639595
2DDR25.03264333
3MAPK154.72253475
4MAP3K64.19746483
5SMG14.01339983
6IRAK33.77666739
7EEF2K3.26961950
8MAP3K113.22018483
9TYRO33.05461343
10FGR2.78564432
11MATK2.78500333
12PINK12.68759661
13ERN12.62963702
14NME22.40930293
15BMX2.38019501
16PDGFRA2.26167796
17PIM22.20316062
18PRKD22.18427561
19DAPK12.17806512
20UHMK12.12959431
21LATS22.05969896
22DYRK1B2.03680321
23CSK2.02539518
24SIK12.01383564
25CDK71.86549498
26ARAF1.76787374
27YES11.74386674
28CDK121.72695767
29AKT31.70730341
30KSR21.67400013
31BRAF1.55785540
32CDK61.52943881
33PIM11.47728767
34BRD41.43989377
35EPHA21.39234778
36TRPM71.34358185
37TBK11.27852423
38CHEK21.17315655
39CDC42BPA1.15525445
40RPS6KL11.13360935
41RPS6KC11.13360935
42MAP2K31.12550088
43GSK3A1.09433221
44FGFR41.08141819
45IRAK21.07614884
46MAP3K101.07244369
47DYRK31.06342417
48PRKD31.02708130
49MTOR0.99035561
50PLK10.98164533
51MAPK110.97509649
52LMTK20.97369701
53MAP3K30.97360478
54RPS6KA60.97255650
55CAMK1D0.97245454
56STK160.93506590
57MAP3K10.90253717
58MAP3K130.89973990
59IRAK40.87983365
60DAPK30.87419213
61CLK10.86587663
62RPS6KA20.84073562
63TRIB30.83875117
64PHKG10.82208233
65PHKG20.82208233
66RPS6KB20.79726883
67HIPK20.77471355
68PKN20.74462544
69CDK90.74283941
70NEK20.72352777
71TAOK20.70964654
72STK40.69978116
73RPS6KA10.68961242
74LATS10.67171862
75PRKAA10.66773612
76MOS0.66711396
77MAP3K50.66353400
78PRPF4B0.64288526
79CAMK1G0.64012782
80PDPK10.63373536
81MARK20.63112943
82CDK80.62799504
83RIPK10.59649467
84MAP3K90.59524210
85ATR0.58254498
86IKBKB0.57544486
87AKT20.57288302
88CDK20.56991407
89BRSK10.56425612
90STK240.55661653
91ALK0.52412642
92PTK20.52038557
93MAP3K140.50877446
94RAF10.50431602
95PTK60.50245540
96STK30.50226344
97CDC70.49976466
98KDR0.49133617
99RPS6KA50.49018544
100PDGFRB0.48654232
101TAOK10.48549659
102NEK10.48511205
103EIF2AK10.47938927
104CHEK10.47398237
105MAP3K20.46080665
106AURKA0.45696453
107EGFR0.45295271
108WEE10.45171851
109MAP2K20.44596263
110ABL20.42955929
111TTK0.42706663
112MAPKAPK30.42539637
113MAPK10.41751826
114TTN0.41164278
115ERBB40.40752056
116SIK30.40378127
117DYRK20.38065669
118CDK190.37772093
119PAK20.37499959
120SIK20.37397430
121PAK40.37125591
122RPS6KB10.36760333
123CSNK2A10.36694752
124CDK40.36412601
125BUB10.36395191
126ATM0.36362075
127KSR10.36039739
128AURKB0.34671797
129MAPK100.34142809
130MAPK140.33607653
131MAPK30.32706831
132STK38L0.32586323
133STK100.29998117
134FLT30.28612917
135CDK10.28405578
136CSNK2A20.27838661
137ERBB30.27816406
138PRKAA20.27541370
139INSR0.26470993
140MAPKAPK20.26082379
141PRKCI0.25587031
142PAK10.24832328
143CHUK0.22556503
144STK380.22150485
145LYN0.22124508
146MAP3K80.21360595
147CSNK1G10.21310968
148TESK20.20590409
149AKT10.19759347
150FGFR10.19360934
151GSK3B0.19079182
152CAMK2G0.17738932

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.92525982
2Mismatch repair_Homo sapiens_hsa034304.65091479
3Base excision repair_Homo sapiens_hsa034104.26917587
4DNA replication_Homo sapiens_hsa030303.46280606
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.00572562
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56992381
7mTOR signaling pathway_Homo sapiens_hsa041502.31367178
8RNA transport_Homo sapiens_hsa030132.29883576
9Nucleotide excision repair_Homo sapiens_hsa034202.16675766
10Hippo signaling pathway_Homo sapiens_hsa043902.15317232
11Other glycan degradation_Homo sapiens_hsa005112.14485510
12mRNA surveillance pathway_Homo sapiens_hsa030152.13983698
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.12933068
14Hedgehog signaling pathway_Homo sapiens_hsa043402.08840650
15Spliceosome_Homo sapiens_hsa030402.04384515
16Notch signaling pathway_Homo sapiens_hsa043302.03679529
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98378012
18Vitamin B6 metabolism_Homo sapiens_hsa007501.87275125
19Adherens junction_Homo sapiens_hsa045201.85449522
20Circadian rhythm_Homo sapiens_hsa047101.80938786
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79073331
22Arginine and proline metabolism_Homo sapiens_hsa003301.77585919
23Prion diseases_Homo sapiens_hsa050201.73736144
24Bladder cancer_Homo sapiens_hsa052191.73120465
25Biosynthesis of amino acids_Homo sapiens_hsa012301.66807535
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65967493
27Fanconi anemia pathway_Homo sapiens_hsa034601.65421881
28Cell cycle_Homo sapiens_hsa041101.63332785
29Homologous recombination_Homo sapiens_hsa034401.62448162
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59877303
31TGF-beta signaling pathway_Homo sapiens_hsa043501.52702013
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48418659
33Pentose phosphate pathway_Homo sapiens_hsa000301.45547644
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40534817
35* p53 signaling pathway_Homo sapiens_hsa041151.37204793
36Sulfur relay system_Homo sapiens_hsa041221.37200919
37Basal cell carcinoma_Homo sapiens_hsa052171.36943552
38Folate biosynthesis_Homo sapiens_hsa007901.33748992
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33303789
40Carbon metabolism_Homo sapiens_hsa012001.28465763
41Lysine degradation_Homo sapiens_hsa003101.23066705
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.22713371
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22238038
44Wnt signaling pathway_Homo sapiens_hsa043101.19296625
45Non-small cell lung cancer_Homo sapiens_hsa052231.18814710
46One carbon pool by folate_Homo sapiens_hsa006701.17568130
47Shigellosis_Homo sapiens_hsa051311.11331930
48MicroRNAs in cancer_Homo sapiens_hsa052061.10997679
49Fructose and mannose metabolism_Homo sapiens_hsa000511.10044603
50VEGF signaling pathway_Homo sapiens_hsa043701.03268042
51Vibrio cholerae infection_Homo sapiens_hsa051101.02971748
52B cell receptor signaling pathway_Homo sapiens_hsa046621.02466660
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.01993353
54Oocyte meiosis_Homo sapiens_hsa041140.99966907
55Fatty acid metabolism_Homo sapiens_hsa012120.99877470
56* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95909470
57Colorectal cancer_Homo sapiens_hsa052100.93457718
58Renal cell carcinoma_Homo sapiens_hsa052110.93227020
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88833761
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88016883
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.87686621
62Tight junction_Homo sapiens_hsa045300.86850035
63Small cell lung cancer_Homo sapiens_hsa052220.85818157
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84987830
65Chronic myeloid leukemia_Homo sapiens_hsa052200.83998025
66Lysosome_Homo sapiens_hsa041420.81752865
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81457567
68N-Glycan biosynthesis_Homo sapiens_hsa005100.81385725
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.81367766
70TNF signaling pathway_Homo sapiens_hsa046680.79056840
71Glioma_Homo sapiens_hsa052140.78790845
72Viral carcinogenesis_Homo sapiens_hsa052030.77744102
73Hepatitis C_Homo sapiens_hsa051600.75565660
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75425140
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75107568
76Dorso-ventral axis formation_Homo sapiens_hsa043200.75055736
77Salmonella infection_Homo sapiens_hsa051320.73305010
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71530447
79Pyrimidine metabolism_Homo sapiens_hsa002400.71104160
80AMPK signaling pathway_Homo sapiens_hsa041520.70840024
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70130429
82Acute myeloid leukemia_Homo sapiens_hsa052210.70026676
83Thyroid cancer_Homo sapiens_hsa052160.69162849
84Influenza A_Homo sapiens_hsa051640.67434509
85ErbB signaling pathway_Homo sapiens_hsa040120.64388660
86Arginine biosynthesis_Homo sapiens_hsa002200.64369163
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63947489
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62589043
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.60952830
90Prolactin signaling pathway_Homo sapiens_hsa049170.60517106
91Choline metabolism in cancer_Homo sapiens_hsa052310.59547381
92Galactose metabolism_Homo sapiens_hsa000520.58964561
93Proteoglycans in cancer_Homo sapiens_hsa052050.58083972
94Viral myocarditis_Homo sapiens_hsa054160.57680255
95Legionellosis_Homo sapiens_hsa051340.57314787
96Insulin signaling pathway_Homo sapiens_hsa049100.56007606
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55235075
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.53719654
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50903240
100Insulin resistance_Homo sapiens_hsa049310.50034374
101FoxO signaling pathway_Homo sapiens_hsa040680.49367492
102Gap junction_Homo sapiens_hsa045400.49353350
103Inositol phosphate metabolism_Homo sapiens_hsa005620.48862582
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48742339
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.48452832
106Selenocompound metabolism_Homo sapiens_hsa004500.47749096
107Endometrial cancer_Homo sapiens_hsa052130.47215257
108Ribosome_Homo sapiens_hsa030100.47006580
109Measles_Homo sapiens_hsa051620.45521554
110Focal adhesion_Homo sapiens_hsa045100.44722674
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44511795
112HTLV-I infection_Homo sapiens_hsa051660.44438884
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.44332178
114RNA degradation_Homo sapiens_hsa030180.43434447
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43115891
116Osteoclast differentiation_Homo sapiens_hsa043800.42196308
117Prostate cancer_Homo sapiens_hsa052150.41811960
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41456461
119Basal transcription factors_Homo sapiens_hsa030220.39807323
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39245950
121Epstein-Barr virus infection_Homo sapiens_hsa051690.39106005
122Systemic lupus erythematosus_Homo sapiens_hsa053220.38639681
123Pathways in cancer_Homo sapiens_hsa052000.38174886
124MAPK signaling pathway_Homo sapiens_hsa040100.33601189
125Glutathione metabolism_Homo sapiens_hsa004800.33520958
126Primary immunodeficiency_Homo sapiens_hsa053400.33320730
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32623073
128Herpes simplex infection_Homo sapiens_hsa051680.32464050
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32364690
130RNA polymerase_Homo sapiens_hsa030200.29791343
131Hepatitis B_Homo sapiens_hsa051610.29607778
132Pancreatic cancer_Homo sapiens_hsa052120.27951787
133HIF-1 signaling pathway_Homo sapiens_hsa040660.27521411
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27049381
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.24428118
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24421546
137Melanoma_Homo sapiens_hsa052180.24001458
138Apoptosis_Homo sapiens_hsa042100.21813397
139Estrogen signaling pathway_Homo sapiens_hsa049150.21319283
140Endocytosis_Homo sapiens_hsa041440.21136122
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19709718

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