SET

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1IMP biosynthetic process (GO:0006188)5.74413871
2nucleobase biosynthetic process (GO:0046112)5.10585427
3purine nucleobase biosynthetic process (GO:0009113)4.97741899
4DNA strand elongation involved in DNA replication (GO:0006271)4.88239963
5IMP metabolic process (GO:0046040)4.83360889
6DNA replication initiation (GO:0006270)4.73969039
7nuclear pore organization (GO:0006999)4.72919015
8telomere maintenance via semi-conservative replication (GO:0032201)4.72654232
9DNA strand elongation (GO:0022616)4.65739870
10DNA double-strand break processing (GO:0000729)4.59632377
11mitotic metaphase plate congression (GO:0007080)4.51308020
12CENP-A containing nucleosome assembly (GO:0034080)4.49563667
13chromatin remodeling at centromere (GO:0031055)4.44105500
14nuclear pore complex assembly (GO:0051292)4.41294886
15ribosome biogenesis (GO:0042254)4.39190392
16kinetochore organization (GO:0051383)4.31808357
17telomere maintenance via recombination (GO:0000722)4.26629818
18DNA replication checkpoint (GO:0000076)4.26029446
19mitotic recombination (GO:0006312)4.11680682
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.10213758
21ribosomal small subunit assembly (GO:0000028)4.09564062
22DNA unwinding involved in DNA replication (GO:0006268)3.96561959
23DNA replication-independent nucleosome organization (GO:0034724)3.92313753
24DNA replication-independent nucleosome assembly (GO:0006336)3.92313753
25mitotic nuclear envelope disassembly (GO:0007077)3.92230245
26double-strand break repair via nonhomologous end joining (GO:0006303)3.91926995
27non-recombinational repair (GO:0000726)3.91926995
28kinetochore assembly (GO:0051382)3.91567481
29protein localization to kinetochore (GO:0034501)3.88746399
30metaphase plate congression (GO:0051310)3.87867189
31telomere maintenance via telomere lengthening (GO:0010833)3.84007019
32regulation of centriole replication (GO:0046599)3.82648292
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.81377186
34ribosome assembly (GO:0042255)3.71441842
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.71260944
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.70897963
37ribonucleoprotein complex biogenesis (GO:0022613)3.70117759
38formation of translation preinitiation complex (GO:0001731)3.68706970
39regulation of double-strand break repair via homologous recombination (GO:0010569)3.66064475
40establishment of chromosome localization (GO:0051303)3.65881720
41histone exchange (GO:0043486)3.64373186
42regulation of helicase activity (GO:0051095)3.62862361
43rRNA modification (GO:0000154)3.62555387
44RNA-dependent DNA replication (GO:0006278)3.61351198
45DNA replication-dependent nucleosome assembly (GO:0006335)3.59464399
46DNA replication-dependent nucleosome organization (GO:0034723)3.59464399
47mitotic spindle checkpoint (GO:0071174)3.58759278
48nuclear envelope disassembly (GO:0051081)3.58461020
49membrane disassembly (GO:0030397)3.58461020
50pore complex assembly (GO:0046931)3.57292313
51transcription-coupled nucleotide-excision repair (GO:0006283)3.57111476
52establishment of viral latency (GO:0019043)3.56675292
53negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.54873021
54mitotic sister chromatid cohesion (GO:0007064)3.50733408
55viral mRNA export from host cell nucleus (GO:0046784)3.49198686
56transcription from RNA polymerase I promoter (GO:0006360)3.46216137
57maturation of SSU-rRNA (GO:0030490)3.45579030
58regulation of DNA endoreduplication (GO:0032875)3.45281418
59DNA catabolic process, exonucleolytic (GO:0000738)3.44695777
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44429161
61proteasome assembly (GO:0043248)3.42249228
62maturation of 5.8S rRNA (GO:0000460)3.41251973
63DNA deamination (GO:0045006)3.40756502
64ribosomal large subunit biogenesis (GO:0042273)3.39763683
65regulation of chromosome segregation (GO:0051983)3.39321794
66attachment of spindle microtubules to kinetochore (GO:0008608)3.38135225
67mitotic sister chromatid segregation (GO:0000070)3.36358311
68deoxyribonucleotide biosynthetic process (GO:0009263)3.35748708
69spliceosomal snRNP assembly (GO:0000387)3.35185270
70pseudouridine synthesis (GO:0001522)3.35031185
71protein localization to chromosome, centromeric region (GO:0071459)3.34368689
72protein K6-linked ubiquitination (GO:0085020)3.33419922
73heterochromatin organization (GO:0070828)3.32031839
74negative regulation of DNA recombination (GO:0045910)3.30722327
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30456437
76regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30456437
77transcription initiation from RNA polymerase I promoter (GO:0006361)3.29555387
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26784699
79somatic hypermutation of immunoglobulin genes (GO:0016446)3.26784699
80negative regulation of ligase activity (GO:0051352)3.25458849
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25458849
82rRNA processing (GO:0006364)3.23077107
83regulation of mitotic sister chromatid separation (GO:0010965)3.22772013
84regulation of mitotic sister chromatid segregation (GO:0033047)3.22772013
85regulation of sister chromatid segregation (GO:0033045)3.22772013
86replication fork processing (GO:0031297)3.22328313
87mitotic spindle assembly checkpoint (GO:0007094)3.20693858
88positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20175720
89DNA topological change (GO:0006265)3.17688521
90regulation of spindle organization (GO:0090224)3.16277416
91telomere maintenance (GO:0000723)3.15456941
92spindle assembly checkpoint (GO:0071173)3.15296455
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.14171290
94isotype switching (GO:0045190)3.14171290
95somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.14171290
96telomere organization (GO:0032200)3.14064106
97regulation of mitotic spindle checkpoint (GO:1903504)3.12766202
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12766202
99rRNA metabolic process (GO:0016072)3.11116433
100cell cycle G1/S phase transition (GO:0044843)3.10965843
101G1/S transition of mitotic cell cycle (GO:0000082)3.10965843
102regulation of gene silencing by RNA (GO:0060966)3.09795489
103regulation of posttranscriptional gene silencing (GO:0060147)3.09795489
104regulation of gene silencing by miRNA (GO:0060964)3.09795489
105inner cell mass cell proliferation (GO:0001833)3.09763394
106spindle checkpoint (GO:0031577)3.09497844
107* DNA replication (GO:0006260)3.08078780
108cullin deneddylation (GO:0010388)3.07883411
109DNA-dependent DNA replication (GO:0006261)3.07547917
110synapsis (GO:0007129)3.06766841
111termination of RNA polymerase I transcription (GO:0006363)3.06708778
1127-methylguanosine mRNA capping (GO:0006370)3.06562125
113transcription elongation from RNA polymerase III promoter (GO:0006385)3.06451343
114termination of RNA polymerase III transcription (GO:0006386)3.06451343
115pre-miRNA processing (GO:0031054)3.06354597
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05613633
117negative regulation of mRNA metabolic process (GO:1903312)3.05400409
118ATP-dependent chromatin remodeling (GO:0043044)3.04145768
1197-methylguanosine RNA capping (GO:0009452)3.03712433
120RNA capping (GO:0036260)3.03712433
121transcription elongation from RNA polymerase I promoter (GO:0006362)3.03118153
122chromatin assembly or disassembly (GO:0006333)3.03111191
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01989715
124negative regulation of mRNA processing (GO:0050686)3.01572488
125meiotic chromosome segregation (GO:0045132)3.01207506
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00019820
127sister chromatid segregation (GO:0000819)2.99585169
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98675576
129negative regulation of sister chromatid segregation (GO:0033046)2.98675576
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.98675576
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98675576
132negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97346691
133negative regulation of chromosome segregation (GO:0051985)2.97207567
134histone mRNA metabolic process (GO:0008334)2.96636784
135mismatch repair (GO:0006298)2.95759508
136rRNA methylation (GO:0031167)2.94352055
137DNA ligation (GO:0006266)2.94310113
138establishment of integrated proviral latency (GO:0075713)2.93890990
139maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92972329
140regulation of centrosome cycle (GO:0046605)2.92757145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.92081097
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.38464982
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98523820
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.78371787
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.66493147
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.37958109
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.23317874
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09620301
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06524813
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04524091
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85534184
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82982857
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71574784
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.70790267
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68434785
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66122020
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.64974907
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48691452
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40257693
20* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.28701743
21AR_21909140_ChIP-Seq_LNCAP_Human2.24235726
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21069293
23VDR_23849224_ChIP-Seq_CD4+_Human2.16816388
24* XRN2_22483619_ChIP-Seq_HELA_Human2.14634840
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12604151
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07249450
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.06810446
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00346878
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98251141
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95681881
31* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93867241
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93330069
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91780942
34DCP1A_22483619_ChIP-Seq_HELA_Human1.90900067
35FOXP3_21729870_ChIP-Seq_TREG_Human1.90378235
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88589299
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88574917
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83673602
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.81439984
40ELK1_19687146_ChIP-ChIP_HELA_Human1.80726609
41TTF2_22483619_ChIP-Seq_HELA_Human1.79519053
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78891276
43EWS_26573619_Chip-Seq_HEK293_Human1.70394854
44GABP_19822575_ChIP-Seq_HepG2_Human1.68379163
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67375491
46* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66676973
47* YY1_21170310_ChIP-Seq_MESCs_Mouse1.66490042
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63821657
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62888557
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62886739
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56092839
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.54377325
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54189877
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52863127
55* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51832488
56CIITA_25753668_ChIP-Seq_RAJI_Human1.47194056
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.46746925
58FUS_26573619_Chip-Seq_HEK293_Human1.45626450
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45376496
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41281046
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40531699
62* SOX2_16153702_ChIP-ChIP_HESCs_Human1.38651126
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.36904857
64* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36748215
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36243184
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33720789
67ZNF274_21170338_ChIP-Seq_K562_Hela1.30791464
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30568268
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29759952
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28526555
71KDM5A_27292631_Chip-Seq_BREAST_Human1.25570716
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22970928
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.22693086
74* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21315156
75* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20566991
76* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19318069
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17026928
78VDR_22108803_ChIP-Seq_LS180_Human1.17015838
79MYC_18940864_ChIP-ChIP_HL60_Human1.16754651
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14114595
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14114595
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14114595
83* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13245854
84* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10763551
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05583268
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05353729
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01754355
88IGF1R_20145208_ChIP-Seq_DFB_Human1.01419548
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01371708
90* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00856593
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00640050
92* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99985700
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99868391
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.96923758
95* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95796642
96MYC_22102868_ChIP-Seq_BL_Human0.95698886
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93563054
98TAF15_26573619_Chip-Seq_HEK293_Human0.93458103
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93375592
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90905384
101* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90267883
102* NANOG_16153702_ChIP-ChIP_HESCs_Human0.86334747
103* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86269284
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.86128443
105P300_19829295_ChIP-Seq_ESCs_Human0.85985871
106IRF1_19129219_ChIP-ChIP_H3396_Human0.83282620
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81939505
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81004183
109* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80536561
110TFEB_21752829_ChIP-Seq_HELA_Human0.79430610
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.79150331
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78443606
113* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78406887
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77738194
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.76634203
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76572687
117* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76164439
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75157297
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73882373
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71113422
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65041992
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.64442727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.43485306
2MP0010094_abnormal_chromosome_stability4.67662291
3MP0003111_abnormal_nucleus_morphology4.24709699
4MP0008057_abnormal_DNA_replication4.14817691
5MP0004957_abnormal_blastocyst_morpholog4.09495285
6MP0003077_abnormal_cell_cycle3.70319574
7MP0008058_abnormal_DNA_repair3.50445522
8MP0008007_abnormal_cellular_replicative3.47439934
9MP0003123_paternal_imprinting3.04711252
10MP0008932_abnormal_embryonic_tissue2.69689261
11MP0003786_premature_aging2.54802070
12MP0003315_abnormal_perineum_morphology2.43546294
13MP0008877_abnormal_DNA_methylation2.31178893
14MP0001730_embryonic_growth_arrest2.24266237
15MP0000350_abnormal_cell_proliferation2.23492251
16MP0002396_abnormal_hematopoietic_system2.04060000
17MP0003718_maternal_effect1.98677079
18MP0005367_renal/urinary_system_phenotyp1.94492580
19MP0000516_abnormal_urinary_system1.94492580
20MP0000566_synostosis1.91992258
21MP0006292_abnormal_olfactory_placode1.85944364
22MP0009053_abnormal_anal_canal1.81725425
23MP0003806_abnormal_nucleotide_metabolis1.78997275
24MP0002102_abnormal_ear_morphology1.75315510
25MP0010352_gastrointestinal_tract_polyps1.73759431
26MP0005380_embryogenesis_phenotype1.72018910
27MP0001672_abnormal_embryogenesis/_devel1.72018910
28MP0003121_genomic_imprinting1.71241308
29MP0001697_abnormal_embryo_size1.62066468
30MP0006035_abnormal_mitochondrial_morpho1.55840763
31MP0003567_abnormal_fetal_cardiomyocyte1.55485223
32MP0003984_embryonic_growth_retardation1.48701820
33MP0004197_abnormal_fetal_growth/weight/1.46298625
34MP0002088_abnormal_embryonic_growth/wei1.44822379
35MP0006072_abnormal_retinal_apoptosis1.44342837
36MP0002085_abnormal_embryonic_tissue1.41974940
37MP0010307_abnormal_tumor_latency1.41274931
38MP0003941_abnormal_skin_development1.39960079
39MP0002160_abnormal_reproductive_system1.36816686
40MP0003186_abnormal_redox_activity1.36315972
41MP0003890_abnormal_embryonic-extraembry1.35910865
42MP0000313_abnormal_cell_death1.35454570
43MP0005408_hypopigmentation1.34676736
44MP0010030_abnormal_orbit_morphology1.34178095
45MP0002080_prenatal_lethality1.33100097
46MP0003119_abnormal_digestive_system1.31932050
47MP0001293_anophthalmia1.31729003
48MP0004782_abnormal_surfactant_physiolog1.25864035
49MP0008789_abnormal_olfactory_epithelium1.24530045
50MP0002084_abnormal_developmental_patter1.24363741
51MP0004808_abnormal_hematopoietic_stem1.22845989
52MP0000490_abnormal_crypts_of1.21347055
53MP0003136_yellow_coat_color1.17766366
54MP0002086_abnormal_extraembryonic_tissu1.17647224
55MP0002210_abnormal_sex_determination1.17235256
56MP0002233_abnormal_nose_morphology1.16670088
57MP0001119_abnormal_female_reproductive1.16431260
58MP0002254_reproductive_system_inflammat1.15982961
59MP0004133_heterotaxia1.07651735
60MP0000049_abnormal_middle_ear1.07565568
61MP0002019_abnormal_tumor_incidence1.05215565
62MP0003937_abnormal_limbs/digits/tail_de1.05200297
63MP0009672_abnormal_birth_weight1.04038770
64MP0002751_abnormal_autonomic_nervous1.03798089
65MP0005389_reproductive_system_phenotype1.02950392
66MP0010234_abnormal_vibrissa_follicle1.00908491
67MP0002111_abnormal_tail_morphology0.98677074
68MP0006036_abnormal_mitochondrial_physio0.97745312
69MP0000647_abnormal_sebaceous_gland0.96336054
70MP0001145_abnormal_male_reproductive0.94718595
71MP0000372_irregular_coat_pigmentation0.94082344
72MP0000358_abnormal_cell_content/0.92856502
73MP0004147_increased_porphyrin_level0.91826314
74MP0005075_abnormal_melanosome_morpholog0.91576212
75MP0001849_ear_inflammation0.89955581
76MP0000015_abnormal_ear_pigmentation0.88497046
77MP0001286_abnormal_eye_development0.88139856
78MP0000428_abnormal_craniofacial_morphol0.87660987
79MP0005394_taste/olfaction_phenotype0.87611208
80MP0005499_abnormal_olfactory_system0.87611208
81MP0000653_abnormal_sex_gland0.86833612
82MP0000579_abnormal_nail_morphology0.86598956
83MP0001529_abnormal_vocalization0.85503599
84MP0001919_abnormal_reproductive_system0.85148904
85MP0002234_abnormal_pharynx_morphology0.84052130
86MP0003115_abnormal_respiratory_system0.83184083
87MP0009703_decreased_birth_body0.82753578
88MP0002653_abnormal_ependyma_morphology0.82661479
89MP0001299_abnormal_eye_distance/0.81628687
90MP0003861_abnormal_nervous_system0.80622831
91MP0001929_abnormal_gametogenesis0.79212047
92MP0003936_abnormal_reproductive_system0.77149824
93MP0003755_abnormal_palate_morphology0.76942334
94MP0002132_abnormal_respiratory_system0.76139499
95MP0003763_abnormal_thymus_physiology0.74708319
96MP0000537_abnormal_urethra_morphology0.73984322
97MP0003787_abnormal_imprinting0.73090894
98MP0005391_vision/eye_phenotype0.73036516
99MP0005395_other_phenotype0.72637221
100MP0001186_pigmentation_phenotype0.72216852
101MP0002090_abnormal_vision0.72018560
102MP0003221_abnormal_cardiomyocyte_apopto0.71380120
103MP0002095_abnormal_skin_pigmentation0.70852340
104MP0002736_abnormal_nociception_after0.69732141
105MP0002938_white_spotting0.69624085
106MP0001188_hyperpigmentation0.69510533
107MP0008995_early_reproductive_senescence0.68445461
108MP0009697_abnormal_copulation0.68432069
109MP0001485_abnormal_pinna_reflex0.68020275
110MP0005253_abnormal_eye_physiology0.65616572
111MP0005076_abnormal_cell_differentiation0.64904816
112MP0005187_abnormal_penis_morphology0.64764460
113MP0005397_hematopoietic_system_phenotyp0.64635990
114MP0001545_abnormal_hematopoietic_system0.64635990
115MP0005266_abnormal_metabolism0.63522414
116MP0000631_abnormal_neuroendocrine_gland0.63400907
117MP0001177_atelectasis0.63137286
118MP0005384_cellular_phenotype0.62980041
119MP0000432_abnormal_head_morphology0.62241153
120MP0003698_abnormal_male_reproductive0.61980145
121MP0009333_abnormal_splenocyte_physiolog0.61960127
122MP0005409_darkened_coat_color0.60877995
123MP0001661_extended_life_span0.60194265
124MP0000703_abnormal_thymus_morphology0.59651464
125MP0002075_abnormal_coat/hair_pigmentati0.58988558
126MP0002092_abnormal_eye_morphology0.56634903
127MP0002697_abnormal_eye_size0.56190609
128MP0000858_altered_metastatic_potential0.55746169
129MP0001915_intracranial_hemorrhage0.55647386
130MP0003942_abnormal_urinary_system0.54738114

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.22590990
2Carpal bone hypoplasia (HP:0001498)4.95976895
3Degeneration of anterior horn cells (HP:0002398)4.44386707
4Abnormality of the anterior horn cell (HP:0006802)4.44386707
5Breast hypoplasia (HP:0003187)4.42709328
6Rectovaginal fistula (HP:0000143)4.00993361
7Rectal fistula (HP:0100590)4.00993361
8Stenosis of the external auditory canal (HP:0000402)3.84426134
9Chromsome breakage (HP:0040012)3.82919522
10Intestinal fistula (HP:0100819)3.70786119
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67907318
12Impulsivity (HP:0100710)3.55137180
13Patellar aplasia (HP:0006443)3.53312716
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.46817943
15Aplasia/Hypoplasia of the patella (HP:0006498)3.45889145
16Ectopic kidney (HP:0000086)3.37764036
17Absent radius (HP:0003974)3.30155037
18Vaginal fistula (HP:0004320)3.29199342
19Absent thumb (HP:0009777)3.20407795
20Aplasia involving forearm bones (HP:0009822)3.08304535
21Absent forearm bone (HP:0003953)3.08304535
2211 pairs of ribs (HP:0000878)3.06036998
23Oral leukoplakia (HP:0002745)3.05496625
24Multiple enchondromatosis (HP:0005701)2.92988375
25Abnormal lung lobation (HP:0002101)2.92370738
26Aplastic anemia (HP:0001915)2.91243710
27Meckel diverticulum (HP:0002245)2.87148201
28Volvulus (HP:0002580)2.86370385
29Abnormality of the labia minora (HP:0012880)2.84448109
30Colon cancer (HP:0003003)2.81983305
31Horseshoe kidney (HP:0000085)2.78558559
32Abnormality of chromosome stability (HP:0003220)2.73310168
33Abnormality of the preputium (HP:0100587)2.70202457
34Abnormality of the ileum (HP:0001549)2.68632151
35Short 1st metacarpal (HP:0010034)2.67317830
36Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.67317830
37Optic nerve coloboma (HP:0000588)2.66469874
38Supernumerary spleens (HP:0009799)2.66422733
39Aplasia/hypoplasia of the humerus (HP:0006507)2.65041195
40Reticulocytopenia (HP:0001896)2.60920065
41Selective tooth agenesis (HP:0001592)2.59824793
42Neoplasm of the adrenal gland (HP:0100631)2.57283502
43Aplasia/Hypoplasia involving the musculature (HP:0001460)2.55432711
44Spastic diplegia (HP:0001264)2.55089120
45Glioma (HP:0009733)2.52405273
46Hyperglycinemia (HP:0002154)2.51723826
47Medulloblastoma (HP:0002885)2.51059884
48Anal stenosis (HP:0002025)2.41338848
49Abnormality of methionine metabolism (HP:0010901)2.40155483
50Abnormal number of erythroid precursors (HP:0012131)2.39373235
51Cerebral hypomyelination (HP:0006808)2.37912615
52Astrocytoma (HP:0009592)2.37774625
53Abnormality of the astrocytes (HP:0100707)2.37774625
54Abnormality of serum amino acid levels (HP:0003112)2.36568415
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.36452565
56Rough bone trabeculation (HP:0100670)2.36244088
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36219015
58Fused cervical vertebrae (HP:0002949)2.34863573
59Abnormality of cells of the erythroid lineage (HP:0012130)2.33489287
60Increased nuchal translucency (HP:0010880)2.33275405
61Premature graying of hair (HP:0002216)2.31834536
62Abnormality of the carotid arteries (HP:0005344)2.30732637
63Triphalangeal thumb (HP:0001199)2.30392572
64Nephroblastoma (Wilms tumor) (HP:0002667)2.30354860
65Bone marrow hypocellularity (HP:0005528)2.30121616
66Myelodysplasia (HP:0002863)2.29204645
67Short humerus (HP:0005792)2.28976275
68Neoplasm of the colon (HP:0100273)2.27714783
69Neoplasm of the adrenal cortex (HP:0100641)2.27257090
70Abnormality of the 1st metacarpal (HP:0010009)2.27173696
71Small intestinal stenosis (HP:0012848)2.22645489
72Duodenal stenosis (HP:0100867)2.22645489
73Breast carcinoma (HP:0003002)2.18525208
74Septo-optic dysplasia (HP:0100842)2.17449871
75Embryonal renal neoplasm (HP:0011794)2.16537023
76Cortical dysplasia (HP:0002539)2.15900284
77Short thumb (HP:0009778)2.15626604
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.15438530
79Hypoplasia of the radius (HP:0002984)2.12321626
80Agnosia (HP:0010524)2.11799347
81Methylmalonic acidemia (HP:0002912)2.09118705
82Aplasia/Hypoplasia of the sternum (HP:0006714)2.07922878
83Acute encephalopathy (HP:0006846)2.07325103
84Increased hepatocellular lipid droplets (HP:0006565)2.06943389
85Hyperglycinuria (HP:0003108)2.06378233
86Type I transferrin isoform profile (HP:0003642)2.05953024
87Missing ribs (HP:0000921)2.02967169
88Pancreatic islet-cell hyperplasia (HP:0004510)2.02776729
89Abnormality of the septum pellucidum (HP:0007375)2.01957855
90Abnormality of serine family amino acid metabolism (HP:0010894)2.01505439
91Abnormality of glycine metabolism (HP:0010895)2.01505439
92Sloping forehead (HP:0000340)2.01472724
93Abnormality of the duodenum (HP:0002246)2.01222267
94Ovarian neoplasm (HP:0100615)2.00864916
95Breast aplasia (HP:0100783)2.00802956
96Intestinal atresia (HP:0011100)2.00695160
97Ependymoma (HP:0002888)1.98690577
98Absent septum pellucidum (HP:0001331)1.97016828
99Biliary tract neoplasm (HP:0100574)1.96162262
100Microretrognathia (HP:0000308)1.95374199
101Abnormal number of incisors (HP:0011064)1.93221387
102Increased serum pyruvate (HP:0003542)1.92146023
103Aplasia/Hypoplasia of the breasts (HP:0010311)1.91970576
104Abnormality of glycolysis (HP:0004366)1.91789467
105Cutaneous melanoma (HP:0012056)1.91567260
106Tracheoesophageal fistula (HP:0002575)1.90839024
107Shawl scrotum (HP:0000049)1.89313639
108Neoplasm of the pancreas (HP:0002894)1.88148892
109Syringomyelia (HP:0003396)1.88075166
110Spinal cord lesions (HP:0100561)1.88075166
111Atresia of the external auditory canal (HP:0000413)1.87911850
112Cellular immunodeficiency (HP:0005374)1.87882116
113Asplenia (HP:0001746)1.87201505
114Acute necrotizing encephalopathy (HP:0006965)1.86438173
115Lipid accumulation in hepatocytes (HP:0006561)1.84304373
116Abnormality of pyrimidine metabolism (HP:0004353)1.83395403
117Cafe-au-lait spot (HP:0000957)1.82753722
118Abnormality of homocysteine metabolism (HP:0010919)1.81753563
119Homocystinuria (HP:0002156)1.81753563
120Uterine neoplasm (HP:0010784)1.81349369
121Choanal atresia (HP:0000453)1.79604739
122Increased CSF lactate (HP:0002490)1.79346358
123Rhabdomyosarcoma (HP:0002859)1.78624143
124Embryonal neoplasm (HP:0002898)1.78213779
125Abnormality of the pons (HP:0007361)1.78112151
126Facial cleft (HP:0002006)1.78012658
127Hypoplasia of the pons (HP:0012110)1.77381486
128Pendular nystagmus (HP:0012043)1.76756668
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76725953
130Squamous cell carcinoma (HP:0002860)1.76310852
131Duplicated collecting system (HP:0000081)1.76232729
132Cerebral edema (HP:0002181)1.75896994
133Carpal synostosis (HP:0009702)1.75594160
134Preaxial hand polydactyly (HP:0001177)1.74733245
135Abnormal trabecular bone morphology (HP:0100671)1.73229042
136Cleft eyelid (HP:0000625)1.72873774
137Tongue fasciculations (HP:0001308)1.72468932
138Dandy-Walker malformation (HP:0001305)1.71122694
139Neoplasm of striated muscle (HP:0009728)1.70477840
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.68376185
141Megaloblastic anemia (HP:0001889)1.67902641
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67447410
143Abnormality of the renal collecting system (HP:0004742)1.67298910
144Bifid tongue (HP:0010297)1.66416670
145Slender long bone (HP:0003100)1.66182642
146High anterior hairline (HP:0009890)1.66074194
147Abnormality of the parathyroid morphology (HP:0011766)1.65202519
148Small hand (HP:0200055)1.65102358
149Short phalanx of the thumb (HP:0009660)1.64833526
150Clubbing of toes (HP:0100760)1.63570175
151Short 4th metacarpal (HP:0010044)1.63379427
152Neoplasm of the small intestine (HP:0100833)1.63373292
153Methylmalonic aciduria (HP:0012120)1.62116867
154Gonadotropin excess (HP:0000837)1.61862737
155Hypoglycemic seizures (HP:0002173)1.61353301
156Angiofibromas (HP:0010615)1.61093780
157Adenoma sebaceum (HP:0009720)1.61093780
158Aqueductal stenosis (HP:0002410)1.60693304
159Progressive macrocephaly (HP:0004481)1.59447044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.04542780
2BUB13.95921783
3SRPK13.92739341
4EIF2AK13.70196343
5CDC73.35974583
6MKNK13.31895567
7BRSK23.15070914
8PLK32.70562272
9TSSK62.69559528
10PLK42.61021173
11MKNK22.58538797
12VRK22.34960700
13ZAK2.21350099
14WNK32.17651153
15TRIM282.16656713
16NEK12.12828327
17AKT32.11118562
18EIF2AK32.04704261
19NUAK12.02982045
20TTK1.97539215
21PLK11.94059673
22VRK11.94026207
23TAF11.93548581
24PASK1.86694763
25BRSK11.86477969
26TNIK1.78930605
27NEK21.66068073
28ATR1.55698517
29STK161.54239953
30EIF2AK21.49967544
31CHEK21.48118570
32CDK71.43489288
33AURKB1.34497228
34STK41.31294886
35STK38L1.25796469
36PNCK1.24879106
37BMPR1B1.24585224
38NEK61.22972048
39EPHA21.20442165
40ACVR1B1.19631969
41ERBB31.18280860
42AURKA1.17670758
43NME21.09062885
44OXSR11.08669591
45CCNB11.07061263
46CLK11.06371204
47RPS6KB21.06306902
48CDK121.04740161
49CHEK11.01705519
50STK391.01058549
51TLK10.93668973
52BRAF0.92980808
53TESK20.91703859
54PIM10.89670918
55ALK0.89555514
56PBK0.89283901
57MAP3K80.88446616
58CSNK1G10.86547719
59STK240.84554087
60TGFBR10.83699049
61ATM0.83002164
62RPS6KA40.81318757
63CSNK2A10.81105623
64CDK20.81055166
65CDK40.77717621
66PLK20.73306346
67PINK10.69030356
68CSNK2A20.68948331
69CSNK1G30.68798611
70MARK30.67142990
71DYRK30.67010537
72CDK80.65906245
73YES10.65242969
74MAP3K140.63455925
75ERBB40.63210935
76CSNK1G20.62896495
77FGFR20.62280336
78MAP3K100.61458182
79CDK10.60336436
80IRAK40.60323922
81IRAK30.59680980
82STK100.59608142
83CDK60.58456772
84NEK90.56202637
85CSNK1A1L0.55852826
86PAK40.54793093
87MELK0.53595970
88MAP3K40.53398664
89FGFR10.51214726
90PRKCI0.50185121
91FRK0.49678946
92BMPR20.48481755
93SGK20.46526211
94BRD40.44262301
95PIM20.42851205
96RPS6KB10.42575584
97TESK10.40699249
98MST40.40496866
99MAP4K20.40305906
100CDK30.37738069
101PDK20.36806246
102RPS6KC10.36596855
103RPS6KL10.36596855
104MINK10.35642859
105SIK30.34476047
106LATS10.34115261
107STK30.33992759
108SMG10.33907955
109GRK10.33846196
110PAK10.32496474
111NME10.32408397
112BCR0.31658406
113DAPK10.30933809
114RPS6KA60.30928412
115PRPF4B0.30806094
116MAPK140.30503726
117CHUK0.29862323
118DYRK20.29298065
119RPS6KA50.29248037
120CSNK1E0.28962578
121MAPKAPK50.28461769
122INSRR0.27646988
123TEC0.27093182
124CASK0.26487397
125PRKDC0.26241288
126SCYL20.24353844
127LATS20.24310991
128MAP2K70.24087257
129FLT30.23722229
130CSNK1D0.23167038
131TAOK20.21877648
132TRPM70.21721792
133TIE10.21282702
134PRKCG0.21085734
135NLK0.19218352

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.07557885
2Mismatch repair_Homo sapiens_hsa034304.53524520
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.08748518
4RNA polymerase_Homo sapiens_hsa030203.68145550
5Proteasome_Homo sapiens_hsa030503.43664962
6Spliceosome_Homo sapiens_hsa030403.30163006
7Homologous recombination_Homo sapiens_hsa034403.21827282
8Base excision repair_Homo sapiens_hsa034103.18957488
9RNA transport_Homo sapiens_hsa030133.18101579
10Nucleotide excision repair_Homo sapiens_hsa034203.01981537
11One carbon pool by folate_Homo sapiens_hsa006702.98015249
12Ribosome_Homo sapiens_hsa030102.75942102
13Cell cycle_Homo sapiens_hsa041102.74530877
14Pyrimidine metabolism_Homo sapiens_hsa002402.70034139
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41620286
16Fanconi anemia pathway_Homo sapiens_hsa034602.31102671
17Non-homologous end-joining_Homo sapiens_hsa034502.16214212
18RNA degradation_Homo sapiens_hsa030182.13657626
19Basal transcription factors_Homo sapiens_hsa030222.11659066
20Propanoate metabolism_Homo sapiens_hsa006401.87031142
21mRNA surveillance pathway_Homo sapiens_hsa030151.80626693
22Purine metabolism_Homo sapiens_hsa002301.61827038
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54472161
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50306396
25p53 signaling pathway_Homo sapiens_hsa041151.47926425
26Pyruvate metabolism_Homo sapiens_hsa006201.42569842
27Steroid biosynthesis_Homo sapiens_hsa001001.42568377
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27084277
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26112896
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16930653
31Epstein-Barr virus infection_Homo sapiens_hsa051691.15114369
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.01565982
33Oocyte meiosis_Homo sapiens_hsa041141.00419453
34Fatty acid elongation_Homo sapiens_hsa000620.97892185
35Systemic lupus erythematosus_Homo sapiens_hsa053220.96633539
36Selenocompound metabolism_Homo sapiens_hsa004500.93810752
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86845988
38Thyroid cancer_Homo sapiens_hsa052160.83876893
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.82794160
40Herpes simplex infection_Homo sapiens_hsa051680.80931307
41Vitamin B6 metabolism_Homo sapiens_hsa007500.76907616
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76671008
43Huntingtons disease_Homo sapiens_hsa050160.76267648
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75825012
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74065383
46Antigen processing and presentation_Homo sapiens_hsa046120.73562541
47Viral carcinogenesis_Homo sapiens_hsa052030.73035710
48Protein export_Homo sapiens_hsa030600.72018216
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68264652
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.67856943
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66943955
52Arachidonic acid metabolism_Homo sapiens_hsa005900.63891051
53HTLV-I infection_Homo sapiens_hsa051660.60192986
54Glutathione metabolism_Homo sapiens_hsa004800.59337851
55Alzheimers disease_Homo sapiens_hsa050100.57793280
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57700664
57MicroRNAs in cancer_Homo sapiens_hsa052060.55656379
58Biosynthesis of amino acids_Homo sapiens_hsa012300.55584184
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55556657
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53730540
61Butanoate metabolism_Homo sapiens_hsa006500.52936411
62Fatty acid metabolism_Homo sapiens_hsa012120.51357027
63Lysine degradation_Homo sapiens_hsa003100.50856555
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47473732
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43333981
66Parkinsons disease_Homo sapiens_hsa050120.41083370
67Legionellosis_Homo sapiens_hsa051340.40702184
68Folate biosynthesis_Homo sapiens_hsa007900.39234112
69Phototransduction_Homo sapiens_hsa047440.39198913
70N-Glycan biosynthesis_Homo sapiens_hsa005100.38910824
71Sulfur metabolism_Homo sapiens_hsa009200.37825458
72TGF-beta signaling pathway_Homo sapiens_hsa043500.37408446
73Galactose metabolism_Homo sapiens_hsa000520.37406573
74Hippo signaling pathway_Homo sapiens_hsa043900.37158508
75beta-Alanine metabolism_Homo sapiens_hsa004100.36758538
76Basal cell carcinoma_Homo sapiens_hsa052170.36192658
77Pentose phosphate pathway_Homo sapiens_hsa000300.35630139
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35507317
79Fatty acid degradation_Homo sapiens_hsa000710.34282482
80Fructose and mannose metabolism_Homo sapiens_hsa000510.33482199
81Small cell lung cancer_Homo sapiens_hsa052220.33112573
82Alcoholism_Homo sapiens_hsa050340.32082600
83Peroxisome_Homo sapiens_hsa041460.31522690
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29367442
85Tryptophan metabolism_Homo sapiens_hsa003800.29097792
86Vitamin digestion and absorption_Homo sapiens_hsa049770.28997150
87Nitrogen metabolism_Homo sapiens_hsa009100.28198562
88Metabolic pathways_Homo sapiens_hsa011000.27674010
89Carbon metabolism_Homo sapiens_hsa012000.27524745
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26715381
91Caffeine metabolism_Homo sapiens_hsa002320.25451690
92Arginine and proline metabolism_Homo sapiens_hsa003300.23638804
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22231031
94Measles_Homo sapiens_hsa051620.21739068
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21624768
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21508694
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21376626
98Influenza A_Homo sapiens_hsa051640.20930889
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20289629
100Ether lipid metabolism_Homo sapiens_hsa005650.18572921
101Melanoma_Homo sapiens_hsa052180.18447920
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18186199
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17352609
104Apoptosis_Homo sapiens_hsa042100.17004815
105Notch signaling pathway_Homo sapiens_hsa043300.16925168
106Prostate cancer_Homo sapiens_hsa052150.16616645
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16206532
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16147067
109Pathways in cancer_Homo sapiens_hsa052000.16094124
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16030863
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15075786
112Adherens junction_Homo sapiens_hsa045200.14425805
113Linoleic acid metabolism_Homo sapiens_hsa005910.12577787
114HIF-1 signaling pathway_Homo sapiens_hsa040660.12157986
115Oxidative phosphorylation_Homo sapiens_hsa001900.11927441
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11806570
117Hepatitis B_Homo sapiens_hsa051610.11676772
118Wnt signaling pathway_Homo sapiens_hsa043100.11640239
119Colorectal cancer_Homo sapiens_hsa052100.10668416
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.10664165
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.10643798
122Retinol metabolism_Homo sapiens_hsa008300.09510209
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.07945052
124Arginine biosynthesis_Homo sapiens_hsa002200.07050692
125Tight junction_Homo sapiens_hsa045300.06830707
126Sulfur relay system_Homo sapiens_hsa041220.06762739
127Autoimmune thyroid disease_Homo sapiens_hsa053200.06633788
128Hedgehog signaling pathway_Homo sapiens_hsa043400.06199790
129Endometrial cancer_Homo sapiens_hsa052130.05741732
130Primary immunodeficiency_Homo sapiens_hsa053400.05584257
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03656695
132FoxO signaling pathway_Homo sapiens_hsa040680.03353669

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