SETD1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.61055996
2nuclear pore complex assembly (GO:0051292)4.89080218
3heterochromatin organization (GO:0070828)4.83100033
4negative regulation of erythrocyte differentiation (GO:0045647)4.80152046
5nuclear pore organization (GO:0006999)4.61679774
6regulation of histone H3-K27 methylation (GO:0061085)4.35556784
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.06757023
8histone H4-K12 acetylation (GO:0043983)4.05772687
9regulation of RNA export from nucleus (GO:0046831)4.02750297
10negative regulation of histone methylation (GO:0031061)3.93222885
11regulation of translational fidelity (GO:0006450)3.83810582
12intracellular estrogen receptor signaling pathway (GO:0030520)3.78596960
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.77478859
14glucocorticoid receptor signaling pathway (GO:0042921)3.76881412
15regulation of translational termination (GO:0006449)3.71745941
16protein localization to kinetochore (GO:0034501)3.71246742
17peptidyl-lysine dimethylation (GO:0018027)3.66794496
18mitotic sister chromatid cohesion (GO:0007064)3.65303794
19mitotic nuclear envelope disassembly (GO:0007077)3.62168009
20NLS-bearing protein import into nucleus (GO:0006607)3.60746266
21RNA stabilization (GO:0043489)3.59467228
22mRNA stabilization (GO:0048255)3.59467228
23mannose metabolic process (GO:0006013)3.58732466
24pore complex assembly (GO:0046931)3.57357930
25DNA unwinding involved in DNA replication (GO:0006268)3.53059127
26regulation of NFAT protein import into nucleus (GO:0051532)3.49298786
27nuclear envelope disassembly (GO:0051081)3.45035721
28membrane disassembly (GO:0030397)3.45035721
29positive regulation of gene expression, epigenetic (GO:0045815)3.42108688
30regulation of nucleobase-containing compound transport (GO:0032239)3.40679508
31dosage compensation (GO:0007549)3.38364624
32mitotic chromosome condensation (GO:0007076)3.35156411
33chromatin assembly (GO:0031497)3.34304570
34positive regulation of histone deacetylation (GO:0031065)3.31779073
35regulation of posttranscriptional gene silencing (GO:0060147)3.31445652
36regulation of gene silencing by miRNA (GO:0060964)3.31445652
37regulation of gene silencing by RNA (GO:0060966)3.31445652
38gene silencing by RNA (GO:0031047)3.31286748
39gene silencing (GO:0016458)3.30493733
40histone H4-K5 acetylation (GO:0043981)3.30278018
41histone H4-K8 acetylation (GO:0043982)3.30278018
42proline biosynthetic process (GO:0006561)3.28747779
43adherens junction assembly (GO:0034333)3.27684620
44sister chromatid segregation (GO:0000819)3.26345083
45modulation by virus of host process (GO:0019054)3.25870013
46histone H4-K16 acetylation (GO:0043984)3.23977535
47spliceosomal tri-snRNP complex assembly (GO:0000244)3.22894225
48mitotic sister chromatid segregation (GO:0000070)3.21520192
49negative regulation of mRNA processing (GO:0050686)3.19782212
50mitotic G1 DNA damage checkpoint (GO:0031571)3.19457425
51negative regulation of RNA splicing (GO:0033119)3.18681928
52cell-substrate adherens junction assembly (GO:0007045)3.18396946
53focal adhesion assembly (GO:0048041)3.18396946
54negative regulation of mRNA metabolic process (GO:1903312)3.16589809
55regulation of histone H3-K9 methylation (GO:0051570)3.16498735
56corticosteroid receptor signaling pathway (GO:0031958)3.16257051
57regulation of sister chromatid cohesion (GO:0007063)3.16032336
58paraxial mesoderm development (GO:0048339)3.14717145
59DNA duplex unwinding (GO:0032508)3.14568907
60cytoplasmic mRNA processing body assembly (GO:0033962)3.12685788
61DNA geometric change (GO:0032392)3.12160527
62regulation of hippo signaling (GO:0035330)3.11248830
63nucleosome disassembly (GO:0006337)3.10811367
64protein-DNA complex disassembly (GO:0032986)3.10811367
65chromatin silencing (GO:0006342)3.09863218
66trophectodermal cell differentiation (GO:0001829)3.09300254
67protein localization to chromosome, centromeric region (GO:0071459)3.06105001
68histone H2A monoubiquitination (GO:0035518)3.04966353
69planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01220052
70establishment of apical/basal cell polarity (GO:0035089)2.99459413
71DNA topological change (GO:0006265)2.99159509
72activation of Rac GTPase activity (GO:0032863)2.98163236
73modulation by symbiont of host cellular process (GO:0044068)2.94926904
74mitotic G1/S transition checkpoint (GO:0044819)2.91601058
75positive regulation of RNA splicing (GO:0033120)2.90603625
76histone H4 acetylation (GO:0043967)2.89567970
77cellular response to epidermal growth factor stimulus (GO:0071364)2.88748732
78embryonic process involved in female pregnancy (GO:0060136)2.87069669
79nuclear envelope organization (GO:0006998)2.86729610
80histone H3-K36 demethylation (GO:0070544)2.85788201
81regulation of early endosome to late endosome transport (GO:2000641)2.85487954
82thymic T cell selection (GO:0045061)2.83539606
83regulation of mitotic spindle organization (GO:0060236)2.82079066
84regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.81718954
85negative regulation of gene expression, epigenetic (GO:0045814)2.81321083
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80157449
87positive regulation of SMAD protein import into nucleus (GO:0060391)2.80124997
88positive regulation of chromosome segregation (GO:0051984)2.79792644
89maternal placenta development (GO:0001893)2.79294339
90* histone H3-K4 methylation (GO:0051568)2.78635896
91positive regulation of DNA-dependent DNA replication (GO:2000105)2.75586416
92regulation of histone methylation (GO:0031060)2.73879157
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.73227360
94histone H3-K4 trimethylation (GO:0080182)2.72670180
95stress granule assembly (GO:0034063)2.72446167
96regulation of chromatin binding (GO:0035561)2.72239889
97DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.72168743
98G1 DNA damage checkpoint (GO:0044783)2.70479907
99response to laminar fluid shear stress (GO:0034616)2.69711046
100negative regulation of histone modification (GO:0031057)2.69463595
101regulation of mRNA stability (GO:0043488)2.68821310
102histone H4 deacetylation (GO:0070933)2.68029921
103regulation of histone H3-K4 methylation (GO:0051569)2.68023202
104negative regulation of cell size (GO:0045792)2.67801485
105negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.67507696
106chromosome condensation (GO:0030261)2.67369362
107apoptotic process involved in morphogenesis (GO:0060561)2.66388908
108folic acid-containing compound biosynthetic process (GO:0009396)2.65649901
109positive regulation by host of viral transcription (GO:0043923)2.65329377
110regulation of DNA damage checkpoint (GO:2000001)2.65273559
111peptidyl-arginine omega-N-methylation (GO:0035247)2.65198220
1123-UTR-mediated mRNA stabilization (GO:0070935)2.64420653
113regulation of spindle organization (GO:0090224)2.63374075
114positive regulation of mitotic sister chromatid separation (GO:1901970)2.62483677
115positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.62483677
116positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.62483677
117mRNA transport (GO:0051028)2.62369977
118nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.62330437
119formation of translation preinitiation complex (GO:0001731)2.62135324
120positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61885001
121response to UV-C (GO:0010225)2.61459451
122histone acetylation (GO:0016573)2.60955689
123histone lysine demethylation (GO:0070076)2.60328964
124DNA replication initiation (GO:0006270)2.59698654
125cellular response to virus (GO:0098586)2.59592533
126internal peptidyl-lysine acetylation (GO:0018393)2.59006059
127* histone lysine methylation (GO:0034968)2.58666155
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56553525
129positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.55865484
130inner cell mass cell proliferation (GO:0001833)2.55063281
131peptidyl-arginine methylation (GO:0018216)2.54469724
132peptidyl-arginine N-methylation (GO:0035246)2.54469724
133histone demethylation (GO:0016577)2.54229201
134histone H3 acetylation (GO:0043966)2.54205954
135protein export from nucleus (GO:0006611)2.54199926
136negative regulation of viral release from host cell (GO:1902187)2.53132370
137* histone methylation (GO:0016571)2.52198226
138histone H3 deacetylation (GO:0070932)2.51986171
139regulation of RNA stability (GO:0043487)2.51905845
140response to epidermal growth factor (GO:0070849)2.51737574
141atrioventricular valve morphogenesis (GO:0003181)2.51404189
142cellular protein complex localization (GO:0034629)2.51135493
143histone deubiquitination (GO:0016578)2.50598974
144DNA conformation change (GO:0071103)2.49100785
145ribosomal small subunit biogenesis (GO:0042274)2.48804949
146modulation by virus of host morphology or physiology (GO:0019048)2.48537803
147Golgi transport vesicle coating (GO:0048200)2.46310133
148COPI coating of Golgi vesicle (GO:0048205)2.46310133
149poly(A)+ mRNA export from nucleus (GO:0016973)2.46009544
150positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.45708026
151regulation of glucose import in response to insulin stimulus (GO:2001273)2.45585036
152snRNA metabolic process (GO:0016073)2.45066143
153proline metabolic process (GO:0006560)2.44413732
154regulation of cholesterol homeostasis (GO:2000188)2.43649168
155regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39319126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57190077
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60474270
3MYC_22102868_ChIP-Seq_BL_Human3.97580860
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.80667930
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40017129
6VDR_21846776_ChIP-Seq_THP-1_Human2.50111770
7KDM2B_26808549_Chip-Seq_DND41_Human2.44438678
8TCF7_22412390_ChIP-Seq_EML_Mouse2.43679778
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27611609
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26227082
11* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.24504963
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17452980
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11886234
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00281925
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99289584
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94458102
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93325720
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.88732040
19ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85982644
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85885968
21ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84679342
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81656826
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81405202
24CIITA_25753668_ChIP-Seq_RAJI_Human1.79550380
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78220682
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76030671
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71495784
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71291026
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69910558
30* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67042627
31* UTX_26944678_Chip-Seq_JUKART_Human1.65384082
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.64714476
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.64235932
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.62646212
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61740717
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60275118
37MAF_26560356_Chip-Seq_TH1_Human1.59877711
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.56641805
39* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55514572
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53890482
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46766748
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46577729
43ZNF263_19887448_ChIP-Seq_K562_Human1.46249721
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45378803
45NCOR1_26117541_ChIP-Seq_K562_Human1.45347128
46KDM2B_26808549_Chip-Seq_K562_Human1.45038131
47RACK7_27058665_Chip-Seq_MCF-7_Human1.44717271
48LXR_22292898_ChIP-Seq_THP-1_Human1.44191046
49* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43941030
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.39861832
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38687204
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37213087
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37213087
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37213087
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37161263
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37091191
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.36478235
58AR_21909140_ChIP-Seq_LNCAP_Human1.35580994
59ATF3_27146783_Chip-Seq_COLON_Human1.34481335
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.33182532
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29302620
62CREB1_26743006_Chip-Seq_LNCaP_Human1.27684656
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27088300
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27042909
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26897073
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26668572
67SMC4_20622854_ChIP-Seq_HELA_Human1.25939762
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25928501
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25021012
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24935275
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24705836
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23656615
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23639839
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.22601430
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.22445314
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21451652
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.21187751
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19443009
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18559318
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16275522
81MAF_26560356_Chip-Seq_TH2_Human1.15840820
82CHD1_26751641_Chip-Seq_LNCaP_Human1.14395591
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13244737
84MYB_26560356_Chip-Seq_TH1_Human1.11292969
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11151062
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11115883
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10969405
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10864287
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10686173
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10059072
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09822660
92P68_20966046_ChIP-Seq_HELA_Human1.09725874
93POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09619098
94* VDR_24763502_ChIP-Seq_THP-1_Human1.09281880
95XRN2_22483619_ChIP-Seq_HELA_Human1.08874617
96* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08848183
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08000727
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.06923147
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.06847373
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06412467
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05533100
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04022584
103* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03146010
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.03031960
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02629616
106TP53_22127205_ChIP-Seq_IMR90_Human1.02566401
107* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02524195
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02193603
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02034006
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01600110
111BCOR_27268052_Chip-Seq_Bcells_Human1.01399054
112SCL_19346495_ChIP-Seq_HPC-7_Human1.01099883
113MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00811096
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00624634
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99519433
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99329598
117* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98631459
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98539992
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98390092
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97715302
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97699623
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96834660
123NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96638403
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95786709
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95663038
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.95595238
127CLOCK_20551151_ChIP-Seq_293T_Human0.94885238
128NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94529144
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93821194
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92447597
131TFEB_21752829_ChIP-Seq_HELA_Human0.92120626
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91939926
133GATA6_25053715_ChIP-Seq_YYC3_Human0.91580187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.42036011
2MP0005076_abnormal_cell_differentiation3.39938376
3MP0010352_gastrointestinal_tract_polyps3.17049077
4MP0005451_abnormal_body_composition3.05170633
5MP0003111_abnormal_nucleus_morphology2.90254068
6MP0009278_abnormal_bone_marrow2.74449351
7MP0008877_abnormal_DNA_methylation2.44361082
8MP0008057_abnormal_DNA_replication2.43642256
9MP0010094_abnormal_chromosome_stability2.42710716
10MP0003077_abnormal_cell_cycle2.34376882
11MP0004957_abnormal_blastocyst_morpholog2.25482991
12MP0000678_abnormal_parathyroid_gland2.25436162
13MP0001730_embryonic_growth_arrest2.22982807
14MP0010307_abnormal_tumor_latency2.22526557
15MP0008961_abnormal_basal_metabolism2.18892531
16MP0002249_abnormal_larynx_morphology2.13921732
17MP0005058_abnormal_lysosome_morphology2.10458145
18MP0003693_abnormal_embryo_hatching2.09796067
19MP0002396_abnormal_hematopoietic_system2.09213397
20MP0000350_abnormal_cell_proliferation2.06534558
21MP0004197_abnormal_fetal_growth/weight/2.06189734
22MP0001672_abnormal_embryogenesis/_devel2.02260377
23MP0005380_embryogenesis_phenotype2.02260377
24MP0005409_darkened_coat_color1.98608507
25MP0003984_embryonic_growth_retardation1.98544075
26MP0002088_abnormal_embryonic_growth/wei1.95036533
27MP0002084_abnormal_developmental_patter1.93479374
28MP0003172_abnormal_lysosome_physiology1.93229486
29MP0004808_abnormal_hematopoietic_stem1.88042832
30MP0001849_ear_inflammation1.86699907
31MP0002086_abnormal_extraembryonic_tissu1.85560355
32MP0002653_abnormal_ependyma_morphology1.85276220
33MP0008260_abnormal_autophagy1.82757770
34MP0003123_paternal_imprinting1.79355141
35MP0002085_abnormal_embryonic_tissue1.77600251
36MP0001697_abnormal_embryo_size1.75022977
37MP0003300_gastrointestinal_ulcer1.73739534
38MP0005397_hematopoietic_system_phenotyp1.71380773
39MP0001545_abnormal_hematopoietic_system1.71380773
40MP0003890_abnormal_embryonic-extraembry1.69491169
41MP0001348_abnormal_lacrimal_gland1.69223845
42MP0003303_peritoneal_inflammation1.65277074
43MP0009333_abnormal_splenocyte_physiolog1.65030426
44MP0000733_abnormal_muscle_development1.61075423
45MP0003566_abnormal_cell_adhesion1.60295466
46MP0004233_abnormal_muscle_weight1.52924272
47MP0003121_genomic_imprinting1.52363000
48MP0002080_prenatal_lethality1.50858926
49MP0009672_abnormal_birth_weight1.50447421
50MP0009840_abnormal_foam_cell1.49050331
51MP0004185_abnormal_adipocyte_glucose1.47647813
52MP0004381_abnormal_hair_follicle1.42338491
53MP0003567_abnormal_fetal_cardiomyocyte1.40736261
54MP0004264_abnormal_extraembryonic_tissu1.38621340
55MP0009703_decreased_birth_body1.37943677
56MP0005501_abnormal_skin_physiology1.35996037
57MP0004858_abnormal_nervous_system1.33985927
58MP0003119_abnormal_digestive_system1.32379922
59MP0010030_abnormal_orbit_morphology1.31001240
60MP0008007_abnormal_cellular_replicative1.30268264
61MP0002796_impaired_skin_barrier1.30191685
62MP0003115_abnormal_respiratory_system1.29252228
63MP0009053_abnormal_anal_canal1.28716867
64MP0002925_abnormal_cardiovascular_devel1.26014583
65MP0005023_abnormal_wound_healing1.25934367
66MP0000703_abnormal_thymus_morphology1.25681775
67MP0000537_abnormal_urethra_morphology1.24710226
68MP0000428_abnormal_craniofacial_morphol1.23065100
69MP0001915_intracranial_hemorrhage1.22861534
70MP0003436_decreased_susceptibility_to1.22691886
71MP0001346_abnormal_lacrimal_gland1.18664651
72MP0001873_stomach_inflammation1.17759354
73MP0010630_abnormal_cardiac_muscle1.15177688
74MP0000569_abnormal_digit_pigmentation1.13942080
75MP0005623_abnormal_meninges_morphology1.13611430
76MP0002009_preneoplasia1.11402930
77MP0003787_abnormal_imprinting1.10026143
78MP0003283_abnormal_digestive_organ1.09567590
79MP0000313_abnormal_cell_death1.06783550
80MP0004947_skin_inflammation1.06350554
81MP0008770_decreased_survivor_rate1.05510204
82MP0008995_early_reproductive_senescence1.04844570
83MP0002019_abnormal_tumor_incidence1.04168573
84MP0008058_abnormal_DNA_repair1.02305159
85MP0000858_altered_metastatic_potential1.02257045
86MP0005666_abnormal_adipose_tissue1.02252877
87MP0001293_anophthalmia1.02057526
88MP0003935_abnormal_craniofacial_develop1.01928897
89MP0000266_abnormal_heart_morphology1.01057772
90MP0009931_abnormal_skin_appearance0.99676160
91MP0010234_abnormal_vibrissa_follicle0.99045550
92MP0003091_abnormal_cell_migration0.98071977
93MP0005375_adipose_tissue_phenotype0.96032514
94MP0000003_abnormal_adipose_tissue0.93094951
95MP0002398_abnormal_bone_marrow0.91722543
96MP0005621_abnormal_cell_physiology0.91432076
97MP0003045_fibrosis0.91260186
98MP0000490_abnormal_crypts_of0.90865399
99MP0002877_abnormal_melanocyte_morpholog0.90756506
100MP0002092_abnormal_eye_morphology0.90421697
101MP0002697_abnormal_eye_size0.90255162
102MP0002060_abnormal_skin_morphology0.87501351
103MP0003942_abnormal_urinary_system0.86333712
104MP0003763_abnormal_thymus_physiology0.85227431
105MP0001661_extended_life_span0.83197824
106MP0000759_abnormal_skeletal_muscle0.83091997
107MP0005670_abnormal_white_adipose0.82340693
108MP0001784_abnormal_fluid_regulation0.81419595
109MP0003122_maternal_imprinting0.81287885
110MP0002722_abnormal_immune_system0.80698205
111MP0002429_abnormal_blood_cell0.79478072
112MP0003786_premature_aging0.79265531
113MP0004087_abnormal_muscle_fiber0.79215436
114MP0000432_abnormal_head_morphology0.79116806
115MP0003861_abnormal_nervous_system0.78369269
116MP0005257_abnormal_intraocular_pressure0.76180706
117MP0002111_abnormal_tail_morphology0.75354807
118MP0005384_cellular_phenotype0.73759309
119MP0002210_abnormal_sex_determination0.72481624
120MP0008932_abnormal_embryonic_tissue0.72240202
121MP0002166_altered_tumor_susceptibility0.72131261
122MP0002269_muscular_atrophy0.71818124
123MP0002970_abnormal_white_adipose0.71472636
124MP0000767_abnormal_smooth_muscle0.70845310
125MP0000747_muscle_weakness0.70616519
126MP0001216_abnormal_epidermal_layer0.70378408
127MP0000681_abnormal_thyroid_gland0.69604199
128MP0002089_abnormal_postnatal_growth/wei0.69294246
129MP0005187_abnormal_penis_morphology0.69291651
130MP0000689_abnormal_spleen_morphology0.69243124
131MP0002114_abnormal_axial_skeleton0.68726505
132MP0001145_abnormal_male_reproductive0.67188062
133MP0003453_abnormal_keratinocyte_physiol0.65552086

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.81500778
2Obstructive sleep apnea (HP:0002870)3.52817998
3Hyperacusis (HP:0010780)3.35496394
4Ependymoma (HP:0002888)3.24688170
5Broad face (HP:0000283)3.06778601
6Abnormality of the lower motor neuron (HP:0002366)3.01377447
7Long eyelashes (HP:0000527)2.99031480
8Cerebral aneurysm (HP:0004944)2.97561221
9Abnormality of the astrocytes (HP:0100707)2.91349871
10Astrocytoma (HP:0009592)2.91349871
11Short 4th metacarpal (HP:0010044)2.90978483
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.90978483
13Urethral obstruction (HP:0000796)2.88591791
14Macroorchidism (HP:0000053)2.76187424
15Increased nuchal translucency (HP:0010880)2.71708971
16Shallow orbits (HP:0000586)2.60323296
17Prominent nose (HP:0000448)2.59161599
18Long palpebral fissure (HP:0000637)2.58936205
19Renal duplication (HP:0000075)2.58832473
20Heterotopia (HP:0002282)2.58527654
21Trigonocephaly (HP:0000243)2.54570976
22Pseudobulbar signs (HP:0002200)2.54031360
23Broad distal phalanx of finger (HP:0009836)2.53083863
24Hemorrhage of the eye (HP:0011885)2.46002151
25Abnormality of the distal phalanx of the thumb (HP:0009617)2.44592571
26Abnormality of the radial head (HP:0003995)2.40217512
27Renovascular hypertension (HP:0100817)2.40215690
28Selective tooth agenesis (HP:0001592)2.38141112
29Broad thumb (HP:0011304)2.38018283
30Thin bony cortex (HP:0002753)2.35336607
31Volvulus (HP:0002580)2.35240792
32Abnormality of the phalanges of the hallux (HP:0010057)2.32438504
33Ulnar bowing (HP:0003031)2.30320871
34Asymmetry of the thorax (HP:0001555)2.27315539
35Abnormality of the 4th metacarpal (HP:0010012)2.27164913
36Distal upper limb amyotrophy (HP:0007149)2.26091916
37Upper limb amyotrophy (HP:0009129)2.26091916
38Broad palm (HP:0001169)2.25746441
39Hand muscle atrophy (HP:0009130)2.24274505
40Elfin facies (HP:0004428)2.23776749
41Deviation of the thumb (HP:0009603)2.23177189
42Proximal placement of thumb (HP:0009623)2.22942917
43Progressive muscle weakness (HP:0003323)2.20975445
44Neoplasm of the oral cavity (HP:0100649)2.20845230
45Abnormality of the thoracic spine (HP:0100711)2.19111805
46Glioma (HP:0009733)2.18323084
47Narrow palate (HP:0000189)2.18309396
48Skin tags (HP:0010609)2.18276296
49Abnormality of the columella (HP:0009929)2.16550621
50Septate vagina (HP:0001153)2.15594535
51Basal cell carcinoma (HP:0002671)2.13787370
52Pointed chin (HP:0000307)2.12792330
53Annular pancreas (HP:0001734)2.11560913
54Dysmetric saccades (HP:0000641)2.11208810
55Facial hemangioma (HP:0000329)2.09442719
56Flat acetabular roof (HP:0003180)2.09361162
57Deep palmar crease (HP:0006191)2.07948675
58Rib fusion (HP:0000902)2.07665312
59Insomnia (HP:0100785)2.07104293
60Distal lower limb amyotrophy (HP:0008944)2.05671595
61Thin ribs (HP:0000883)2.04866824
62Increased density of long bones (HP:0006392)2.04003856
63Anal stenosis (HP:0002025)2.03113899
64Supernumerary ribs (HP:0005815)2.02888478
65Turricephaly (HP:0000262)2.02131435
66Genu recurvatum (HP:0002816)2.02082313
67Obsessive-compulsive behavior (HP:0000722)2.02058662
68High pitched voice (HP:0001620)2.01953969
69Deep venous thrombosis (HP:0002625)2.01287419
70Stridor (HP:0010307)2.00390368
71Neoplasm of striated muscle (HP:0009728)1.99397467
72Vaginal fistula (HP:0004320)1.98059048
73Achilles tendon contracture (HP:0001771)1.98028450
74Overriding aorta (HP:0002623)1.96788082
75Medulloblastoma (HP:0002885)1.96161621
76Increased connective tissue (HP:0009025)1.94866868
77Myopathic facies (HP:0002058)1.94477736
78Progressive external ophthalmoplegia (HP:0000590)1.94192013
79Bowel incontinence (HP:0002607)1.92387184
80Truncus arteriosus (HP:0001660)1.92151264
81Premature skin wrinkling (HP:0100678)1.91718458
82Abnormal number of incisors (HP:0011064)1.91457410
83Gastrointestinal carcinoma (HP:0002672)1.91182094
84Malignant gastrointestinal tract tumors (HP:0006749)1.91182094
85Bowel diverticulosis (HP:0005222)1.88372898
86Centrally nucleated skeletal muscle fibers (HP:0003687)1.86347693
87Aneurysm (HP:0002617)1.84980398
88Biconcave vertebral bodies (HP:0004586)1.84972017
89Broad phalanges of the hand (HP:0009768)1.84916609
90Sandal gap (HP:0001852)1.84295863
91Neoplasm of the heart (HP:0100544)1.83533334
92Enlarged penis (HP:0000040)1.83320934
93Patellar dislocation (HP:0002999)1.82018650
94Truncal obesity (HP:0001956)1.81844536
95Abnormal large intestine physiology (HP:0012700)1.81748799
96Preauricular skin tag (HP:0000384)1.81023939
97Germ cell neoplasia (HP:0100728)1.80590214
98Thoracic kyphosis (HP:0002942)1.80109820
99Reticulocytosis (HP:0001923)1.79593069
100Intestinal fistula (HP:0100819)1.79405194
101Abnormality of the Achilles tendon (HP:0005109)1.79224064
102Vertebral arch anomaly (HP:0008438)1.78448515
103Squamous cell carcinoma (HP:0002860)1.77991768
104Abnormality of the humeroradial joint (HP:0100744)1.77910511
105Abnormality of the labia minora (HP:0012880)1.77909484
106Abnormality of the aortic arch (HP:0012303)1.77722465
107Short 5th finger (HP:0009237)1.77479050
108Mitral valve prolapse (HP:0001634)1.77314837
109Rectal prolapse (HP:0002035)1.76568567
110Ankle contracture (HP:0006466)1.75628288
111Skull defect (HP:0001362)1.75484842
112Cafe-au-lait spot (HP:0000957)1.74736360
113Self-mutilation (HP:0000742)1.74384011
114Supernumerary nipples (HP:0002558)1.74305883
115Cutis marmorata (HP:0000965)1.73805163
116Easy fatigability (HP:0003388)1.73149029
117Short phalanx of the thumb (HP:0009660)1.71997007
118Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71585407
119Broad finger (HP:0001500)1.69646499
120Ectopic kidney (HP:0000086)1.69597755
121Metaphyseal cupping (HP:0003021)1.69527851
122Supernumerary bones of the axial skeleton (HP:0009144)1.69249094
123Mitral regurgitation (HP:0001653)1.69120473
124Spina bifida occulta (HP:0003298)1.68462712
125Spinal cord lesions (HP:0100561)1.68155022
126Syringomyelia (HP:0003396)1.68155022
127Fibroma (HP:0010614)1.67547357
128Abnormality of the diencephalon (HP:0010662)1.67373446
129Protrusio acetabuli (HP:0003179)1.66647013
130Bowed forearm bones (HP:0003956)1.66405992
131Bowing of the arm (HP:0006488)1.66405992
132Shawl scrotum (HP:0000049)1.65945994
133Trismus (HP:0000211)1.65227490
134Attention deficit hyperactivity disorder (HP:0007018)1.64991012
135Disproportionate tall stature (HP:0001519)1.64847886
136Leiomyosarcoma (HP:0100243)1.64532917
137Uterine leiomyosarcoma (HP:0002891)1.64532917
138Sacral dimple (HP:0000960)1.63694356
139Fibrous tissue neoplasm (HP:0012316)1.63426822
140Acute lymphatic leukemia (HP:0006721)1.62177541
141Overlapping toe (HP:0001845)1.61813085
142Dislocated radial head (HP:0003083)1.61775748
143Slow saccadic eye movements (HP:0000514)1.61308120
144Segmental peripheral demyelination/remyelination (HP:0003481)1.60031265
145Ankyloglossia (HP:0010296)1.60029262
146Testicular atrophy (HP:0000029)1.59746674
147Spinal muscular atrophy (HP:0007269)1.59664959
148Seborrheic dermatitis (HP:0001051)1.58665427
149Persistence of primary teeth (HP:0006335)1.58314332
150Limited elbow extension (HP:0001377)1.58235977
151Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.57926097
152Hypercortisolism (HP:0001578)1.57260464
153Rectal fistula (HP:0100590)1.57064887
154Rectovaginal fistula (HP:0000143)1.57064887
155Cellulitis (HP:0100658)1.56748260
156Vertebral fusion (HP:0002948)1.55364910
157Sparse lateral eyebrow (HP:0005338)1.55199913
158Vertebral compression fractures (HP:0002953)1.55105651
159Broad phalanx (HP:0006009)1.54612255
160Nasolacrimal duct obstruction (HP:0000579)1.54334905
161Depressed nasal tip (HP:0000437)1.54307967
162Cholecystitis (HP:0001082)1.54278317
163Abnormal gallbladder physiology (HP:0012438)1.54278317
164High anterior hairline (HP:0009890)1.53473536
165Arnold-Chiari malformation (HP:0002308)1.52933046
166Hypertensive crisis (HP:0100735)1.52689408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.13134757
2SMG13.97981129
3EEF2K3.77556484
4PRPF4B3.66817951
5MAP3K103.20776299
6TRIB33.14880780
7PKN22.53718264
8ICK2.51289822
9BRD42.48657140
10CDC72.36924712
11IRAK32.18092784
12NEK22.12604521
13LATS12.00891066
14CAMK1D1.85824600
15RIPK11.79999518
16CAMK1G1.76939385
17MTOR1.76445284
18ALK1.70651359
19ERN11.70010174
20TAOK11.68785026
21MAP4K11.52513505
22TYRO31.50876153
23CDK41.49490242
24LATS21.47173176
25SIK21.44863028
26BMX1.42921124
27SIK31.40895350
28PDGFRA1.39782757
29SIK11.38117563
30NME21.33357999
31PTK61.28637902
32CDK61.24921906
33STK101.22422448
34CDK71.21099409
35DMPK1.20760994
36TTN1.18807301
37TAOK21.15271654
38RPS6KB21.13461061
39TTK1.12901192
40PRKD31.07726249
41STK31.07075757
42CHEK11.05568431
43MAP3K131.04293301
44PAK41.00212739
45NEK10.93084901
46IRAK20.91522583
47ATR0.89812084
48HIPK20.88235076
49CDK20.85651089
50GRK60.83984485
51MAP3K80.82704082
52SCYL20.80974603
53PAK20.80585146
54MAP3K70.79911699
55CDK90.78791028
56PDGFRB0.78443333
57MAP3K10.75651311
58PDPK10.72879348
59MAP3K60.72082883
60MAP2K30.71887166
61RPS6KC10.70761565
62RPS6KL10.70761565
63ATM0.70594079
64MARK20.70387114
65FGFR10.69952815
66PASK0.69348458
67DDR20.69087985
68LRRK20.67886549
69PRKD20.67714553
70CHUK0.67298693
71CHEK20.66394845
72RPS6KA40.65013040
73PTK20.64665530
74MAP3K140.64432208
75MAP2K20.64322881
76CDC42BPA0.62829317
77MAP3K30.61839900
78PLK10.61688843
79RPS6KA20.61604669
80RIPK40.61529611
81STK380.61471548
82EPHA20.60180860
83PIM10.59942786
84MAP3K90.59761179
85IRAK40.57795471
86TSSK60.56782505
87STK40.55565968
88CAMK40.55228981
89PRKCH0.55049292
90FGFR40.55002362
91BRAF0.54901396
92CDK10.54691894
93ZAP700.54496362
94SGK30.52369822
95CSNK1E0.52241160
96FGFR30.51963640
97MAPK140.51826644
98RPS6KA60.51500876
99RET0.50975273
100AKT20.50797552
101MAPK10.50590329
102RPS6KA10.49443994
103CLK10.48790096
104KSR20.48693277
105AURKB0.47650960
106CSNK1D0.47512991
107MAPK120.46897584
108GSK3B0.46389406
109PAK60.43263097
110PRKDC0.43213536
111MAP3K110.42776236
112MAPK100.42099449
113MAPK150.42092547
114HCK0.41592508
115TESK20.41137685
116JAK30.40195296
117MST1R0.39254091
118PNCK0.39073446
119AKT10.38423030
120PDK10.38291486
121TYK20.38239722
122MAPK80.37885328
123MAPK110.37758754
124STK110.37571924
125WEE10.35919087
126MELK0.35914681
127CDK80.35909658
128MAPK70.35492650
129TBK10.35092205
130CSK0.33369912
131WNK10.33334837
132CSF1R0.32454424
133MAPKAPK30.31794886

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030152.12584984
2* Lysine degradation_Homo sapiens_hsa003102.09813544
3RNA transport_Homo sapiens_hsa030131.98287223
4Other glycan degradation_Homo sapiens_hsa005111.97510660
5Chronic myeloid leukemia_Homo sapiens_hsa052201.92157574
6mTOR signaling pathway_Homo sapiens_hsa041501.89617692
7Notch signaling pathway_Homo sapiens_hsa043301.81020017
8Cell cycle_Homo sapiens_hsa041101.66257485
9MicroRNAs in cancer_Homo sapiens_hsa052061.57926066
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57748230
11Spliceosome_Homo sapiens_hsa030401.57633953
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55998897
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51505904
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.50254389
15Adherens junction_Homo sapiens_hsa045201.49980916
16One carbon pool by folate_Homo sapiens_hsa006701.47515999
17DNA replication_Homo sapiens_hsa030301.45920730
18Acute myeloid leukemia_Homo sapiens_hsa052211.45881008
19Non-small cell lung cancer_Homo sapiens_hsa052231.40214747
20Small cell lung cancer_Homo sapiens_hsa052221.39265173
21Dorso-ventral axis formation_Homo sapiens_hsa043201.38923421
22Basal cell carcinoma_Homo sapiens_hsa052171.33238509
23Colorectal cancer_Homo sapiens_hsa052101.31718174
24Endometrial cancer_Homo sapiens_hsa052131.31512571
25Fructose and mannose metabolism_Homo sapiens_hsa000511.28070840
26Sulfur relay system_Homo sapiens_hsa041221.27161833
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.26021948
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25819637
29Hippo signaling pathway_Homo sapiens_hsa043901.24936673
30Proteoglycans in cancer_Homo sapiens_hsa052051.24313912
31HTLV-I infection_Homo sapiens_hsa051661.24046099
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19894646
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.18422439
34B cell receptor signaling pathway_Homo sapiens_hsa046621.17473290
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17029460
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16940884
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16434469
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16312352
39Base excision repair_Homo sapiens_hsa034101.16261657
40Mismatch repair_Homo sapiens_hsa034301.16104231
41Thyroid cancer_Homo sapiens_hsa052161.14598253
42Pancreatic cancer_Homo sapiens_hsa052121.14361710
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13933521
44Glioma_Homo sapiens_hsa052141.12861418
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12313322
46VEGF signaling pathway_Homo sapiens_hsa043701.09402014
47Prion diseases_Homo sapiens_hsa050201.04543897
48Viral carcinogenesis_Homo sapiens_hsa052031.03450265
49Bladder cancer_Homo sapiens_hsa052191.02764372
50Insulin resistance_Homo sapiens_hsa049311.02591551
51Herpes simplex infection_Homo sapiens_hsa051681.00730054
52Viral myocarditis_Homo sapiens_hsa054160.98020247
53Renal cell carcinoma_Homo sapiens_hsa052110.97464539
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97400461
55Prostate cancer_Homo sapiens_hsa052150.96860700
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95009451
57p53 signaling pathway_Homo sapiens_hsa041150.94457520
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93731641
59Hedgehog signaling pathway_Homo sapiens_hsa043400.92946411
60Oocyte meiosis_Homo sapiens_hsa041140.91291094
61T cell receptor signaling pathway_Homo sapiens_hsa046600.89885066
62TGF-beta signaling pathway_Homo sapiens_hsa043500.89621355
63Pentose phosphate pathway_Homo sapiens_hsa000300.89439483
64Focal adhesion_Homo sapiens_hsa045100.88367041
65Hepatitis C_Homo sapiens_hsa051600.87641921
66Insulin signaling pathway_Homo sapiens_hsa049100.86721630
67Type II diabetes mellitus_Homo sapiens_hsa049300.86574362
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86263156
69AMPK signaling pathway_Homo sapiens_hsa041520.85763741
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.85703380
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85232134
72Prolactin signaling pathway_Homo sapiens_hsa049170.84455313
73Estrogen signaling pathway_Homo sapiens_hsa049150.84171861
74HIF-1 signaling pathway_Homo sapiens_hsa040660.82196424
75Hepatitis B_Homo sapiens_hsa051610.81962261
76Pathways in cancer_Homo sapiens_hsa052000.81486972
77FoxO signaling pathway_Homo sapiens_hsa040680.80728077
78ErbB signaling pathway_Homo sapiens_hsa040120.80130119
79Measles_Homo sapiens_hsa051620.79086049
80Nitrogen metabolism_Homo sapiens_hsa009100.78417235
81GnRH signaling pathway_Homo sapiens_hsa049120.76442742
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75933901
83Wnt signaling pathway_Homo sapiens_hsa043100.75234363
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75027538
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.73839006
86Primary immunodeficiency_Homo sapiens_hsa053400.73750622
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73587650
88Antigen processing and presentation_Homo sapiens_hsa046120.71359344
89RNA degradation_Homo sapiens_hsa030180.71208156
90Osteoclast differentiation_Homo sapiens_hsa043800.69880767
91Toxoplasmosis_Homo sapiens_hsa051450.68175152
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68000174
93Epstein-Barr virus infection_Homo sapiens_hsa051690.67295765
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.67229481
95Glucagon signaling pathway_Homo sapiens_hsa049220.67222292
96MAPK signaling pathway_Homo sapiens_hsa040100.66954956
97Apoptosis_Homo sapiens_hsa042100.66484813
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.64115424
99Choline metabolism in cancer_Homo sapiens_hsa052310.63876462
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63118671
101Rap1 signaling pathway_Homo sapiens_hsa040150.62080901
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.61974950
103Biosynthesis of amino acids_Homo sapiens_hsa012300.61940815
104Long-term potentiation_Homo sapiens_hsa047200.61170908
105Platelet activation_Homo sapiens_hsa046110.60839322
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.60829423
107Influenza A_Homo sapiens_hsa051640.58757214
108Amoebiasis_Homo sapiens_hsa051460.58566320
109Fanconi anemia pathway_Homo sapiens_hsa034600.57485444
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56788646
111Inositol phosphate metabolism_Homo sapiens_hsa005620.56219612
112Shigellosis_Homo sapiens_hsa051310.56067269
113Tight junction_Homo sapiens_hsa045300.54938855
114Selenocompound metabolism_Homo sapiens_hsa004500.54856769
115Galactose metabolism_Homo sapiens_hsa000520.54817626
116Melanoma_Homo sapiens_hsa052180.54661968
117Fatty acid biosynthesis_Homo sapiens_hsa000610.52878670
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52381740
119Melanogenesis_Homo sapiens_hsa049160.52332685
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52330914
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.50684639
122Endocytosis_Homo sapiens_hsa041440.49019661
123TNF signaling pathway_Homo sapiens_hsa046680.48196609
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.47134763
125Chemokine signaling pathway_Homo sapiens_hsa040620.46984297

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