SETD1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)4.53185363
2positive thymic T cell selection (GO:0045059)4.43107610
3histone H3-K4 trimethylation (GO:0080182)4.39706192
4negative regulation of cell killing (GO:0031342)4.19415326
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19415326
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.07313263
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00528054
8positive regulation of gamma-delta T cell activation (GO:0046645)3.80386758
9antigen processing and presentation of endogenous antigen (GO:0019883)3.80022300
10response to muramyl dipeptide (GO:0032495)3.73859906
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73815689
12T cell selection (GO:0045058)3.73665129
13thymic T cell selection (GO:0045061)3.67559629
14response to laminar fluid shear stress (GO:0034616)3.50143927
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48248911
16negative regulation of translation, ncRNA-mediated (GO:0040033)3.48248911
17regulation of translation, ncRNA-mediated (GO:0045974)3.48248911
18positive regulation of histone deacetylation (GO:0031065)3.46090905
19regulation of histone H3-K27 methylation (GO:0061085)3.34904372
20interferon-gamma production (GO:0032609)3.34136001
21detection of other organism (GO:0098543)3.33947960
22regulation of B cell receptor signaling pathway (GO:0050855)3.33671782
23negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.32996116
24detection of bacterium (GO:0016045)3.30817884
25modulation by virus of host process (GO:0019054)3.25390924
26positive regulation by host of viral transcription (GO:0043923)3.23814938
27negative regulation of erythrocyte differentiation (GO:0045647)3.21903076
28mannose metabolic process (GO:0006013)3.19989056
29erythrocyte maturation (GO:0043249)3.18302160
30negative T cell selection (GO:0043383)3.15140153
31* histone H3-K4 methylation (GO:0051568)3.12921953
32response to peptidoglycan (GO:0032494)3.12171231
33cellular extravasation (GO:0045123)3.09977926
34macrophage activation involved in immune response (GO:0002281)3.06417875
35forebrain neuron differentiation (GO:0021879)3.00559160
36tolerance induction (GO:0002507)2.99979275
37regulation of gamma-delta T cell differentiation (GO:0045586)2.99318533
38regulation of NFAT protein import into nucleus (GO:0051532)2.98793614
39negative regulation of lymphocyte mediated immunity (GO:0002707)2.96714701
40negative thymic T cell selection (GO:0045060)2.95708777
41peptidyl-lysine trimethylation (GO:0018023)2.95685144
42germinal center formation (GO:0002467)2.93636258
43negative regulation of T cell mediated immunity (GO:0002710)2.92801521
44histone lysine demethylation (GO:0070076)2.91941541
45regulation of gamma-delta T cell activation (GO:0046643)2.91647535
46activated T cell proliferation (GO:0050798)2.88176772
47negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87503705
48B cell receptor signaling pathway (GO:0050853)2.85598667
49histone demethylation (GO:0016577)2.85587784
50megakaryocyte development (GO:0035855)2.83724274
51positive regulation of Rap GTPase activity (GO:0032854)2.81222750
52regulation of granulocyte differentiation (GO:0030852)2.80448940
53nucleosome disassembly (GO:0006337)2.79988154
54protein-DNA complex disassembly (GO:0032986)2.79988154
55negative regulation of leukocyte mediated immunity (GO:0002704)2.79761704
56regulation of T cell tolerance induction (GO:0002664)2.77446196
57detection of external biotic stimulus (GO:0098581)2.74445605
58epithelial cell fate commitment (GO:0072148)2.73985416
59positive regulation of gene expression, epigenetic (GO:0045815)2.73819852
60histone H4-K12 acetylation (GO:0043983)2.67922404
61regulation of interferon-beta biosynthetic process (GO:0045357)2.67832767
62V(D)J recombination (GO:0033151)2.66968356
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65297231
64histone H3-K36 demethylation (GO:0070544)2.64884358
65positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.64230931
66NIK/NF-kappaB signaling (GO:0038061)2.64063565
67negative regulation of interleukin-12 production (GO:0032695)2.63571049
68embryonic process involved in female pregnancy (GO:0060136)2.63443206
69RNA stabilization (GO:0043489)2.62387509
70mRNA stabilization (GO:0048255)2.62387509
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.61902419
72mRNA splice site selection (GO:0006376)2.61767753
73neutrophil activation involved in immune response (GO:0002283)2.61184435
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60335964
75response to host (GO:0075136)2.60335964
76response to host defenses (GO:0052200)2.60335964
77granulocyte differentiation (GO:0030851)2.60150460
78negative regulation of glial cell proliferation (GO:0060253)2.60016629
79modulation by symbiont of host cellular process (GO:0044068)2.57941987
80face development (GO:0060324)2.57521019
81signal complex assembly (GO:0007172)2.57300214
82negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55906682
83regulation of tolerance induction (GO:0002643)2.55811336
84cellular response to interleukin-15 (GO:0071350)2.55724227
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55379415
86response to host immune response (GO:0052572)2.55379415
87regulation of histone deacetylation (GO:0031063)2.55277022
88regulation of histone H3-K4 methylation (GO:0051569)2.55215983
89hematopoietic stem cell differentiation (GO:0060218)2.54385207
90leukocyte aggregation (GO:0070486)2.54239617
91negative regulation of RNA splicing (GO:0033119)2.54051598
92regulation of T-helper 2 cell differentiation (GO:0045628)2.53444207
93regulation of ARF protein signal transduction (GO:0032012)2.53157687
94antigen processing and presentation via MHC class Ib (GO:0002475)2.51468755
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51256213
96definitive hemopoiesis (GO:0060216)2.50571842
97mature B cell differentiation (GO:0002335)2.50046495
98T cell receptor signaling pathway (GO:0050852)2.49009653
99positive regulation of protein deacetylation (GO:0090312)2.48371697
100protein dealkylation (GO:0008214)2.48164032
101protein demethylation (GO:0006482)2.48164032
102negative regulation of phagocytosis (GO:0050765)2.48003584
103cytoplasmic mRNA processing body assembly (GO:0033962)2.47818926
104B cell homeostasis (GO:0001782)2.46295595
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45870928
106histone H3-K9 demethylation (GO:0033169)2.44956819
107alpha-beta T cell differentiation (GO:0046632)2.44779874
108detection of molecule of bacterial origin (GO:0032490)2.42694088
109radial glial cell differentiation (GO:0060019)2.42565172
110regulation of chromatin binding (GO:0035561)2.42135391
1113-UTR-mediated mRNA stabilization (GO:0070935)2.42114580
112JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.41721012
113negative regulation of interleukin-6 production (GO:0032715)2.41582227
114negative regulation of mRNA processing (GO:0050686)2.39810465
115T cell differentiation (GO:0030217)2.39465733
116positive regulation of B cell differentiation (GO:0045579)2.38700393
117embryonic hemopoiesis (GO:0035162)2.38447692
118antigen receptor-mediated signaling pathway (GO:0050851)2.37193284
119T cell homeostasis (GO:0043029)2.36048595
120head development (GO:0060322)2.35894567
121CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.34669721
122intracellular estrogen receptor signaling pathway (GO:0030520)2.34600359
123T cell migration (GO:0072678)2.34253910
124alpha-beta T cell activation (GO:0046631)2.33755614
125histone H3 acetylation (GO:0043966)2.32955112
126cell proliferation in forebrain (GO:0021846)2.31156633
127positive regulation by symbiont of host defense response (GO:0052509)2.31051690
128modulation by symbiont of host defense response (GO:0052031)2.31051690
129modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.31051690
130modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.31051690
131positive regulation by organism of defense response of other organism involved in symbiotic interact2.31051690
132modulation by symbiont of host immune response (GO:0052553)2.31051690
133negative regulation of granulocyte differentiation (GO:0030853)2.30891488
134embryonic camera-type eye morphogenesis (GO:0048596)2.30505561
135lymphoid progenitor cell differentiation (GO:0002320)2.29344493
136regulation of B cell differentiation (GO:0045577)2.29296484
137histone H4-K16 acetylation (GO:0043984)2.29031945
138negative regulation of Ras GTPase activity (GO:0034261)2.28042243
139* histone lysine methylation (GO:0034968)2.27930880
140cranial nerve morphogenesis (GO:0021602)2.26550540
141negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.26258728
142regulation of interleukin-2 biosynthetic process (GO:0045076)2.25415266
143positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25373909
144regulation of erythrocyte differentiation (GO:0045646)2.25151850
145positive regulation of CREB transcription factor activity (GO:0032793)2.24521525
146spinal cord development (GO:0021510)2.24380281
147response to interleukin-15 (GO:0070672)2.24353069
148generation of neurons (GO:0048699)2.22798480
149negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.21928016
150negative regulation of T-helper cell differentiation (GO:0045623)2.21928016
151lymph node development (GO:0048535)2.20842169
152male sex determination (GO:0030238)2.20718090
153atrial septum morphogenesis (GO:0060413)2.16997243
154negative regulation of alpha-beta T cell activation (GO:0046636)2.14503239
155positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.14215754
156positive regulation of granulocyte differentiation (GO:0030854)2.14171476
157regulation of stem cell maintenance (GO:2000036)2.12207326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.02180720
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.89832848
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.39300376
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19044315
5MYC_22102868_ChIP-Seq_BL_Human3.12029793
6SCL_19346495_ChIP-Seq_HPC-7_Human2.99328396
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.87812295
8* VDR_21846776_ChIP-Seq_THP-1_Human2.69166115
9TCF7_22412390_ChIP-Seq_EML_Mouse2.61842374
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59471550
11* KDM2B_26808549_Chip-Seq_DND41_Human2.58212815
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.52136973
13* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.28498472
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19986562
15MAF_26560356_Chip-Seq_TH1_Human2.17203271
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14743560
17EZH2_22144423_ChIP-Seq_EOC_Human2.14253218
18* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13445614
19* KDM2B_26808549_Chip-Seq_JURKAT_Human2.12288047
20UTX_26944678_Chip-Seq_JUKART_Human2.02349758
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.00886803
22* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99225193
23RUNX_20019798_ChIP-Seq_JUKART_Human1.95573403
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95486700
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.95040436
26* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89857269
27* VDR_24763502_ChIP-Seq_THP-1_Human1.89511794
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84847485
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84658164
30RACK7_27058665_Chip-Seq_MCF-7_Human1.78406828
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77307637
32KDM2B_26808549_Chip-Seq_K562_Human1.76605022
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75725059
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71517121
35MYB_26560356_Chip-Seq_TH1_Human1.67216545
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65170455
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55225080
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55096871
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.52120006
40MYB_26560356_Chip-Seq_TH2_Human1.48862226
41MAF_26560356_Chip-Seq_TH2_Human1.47810191
42CIITA_25753668_ChIP-Seq_RAJI_Human1.47259403
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.44303678
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.42291572
45SPI1_23547873_ChIP-Seq_NB4_Human1.41628360
46DROSHA_22980978_ChIP-Seq_HELA_Human1.40169795
47SPI1_23127762_ChIP-Seq_K562_Human1.39392036
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.38533052
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38104136
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37726564
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.35888604
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34626880
53* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33743697
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32098984
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.31921400
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.31715415
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.31366788
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31103799
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.30149030
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.29984898
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28814716
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28814716
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28814716
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28342685
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27493873
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25159168
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25107200
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.24971223
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.24455125
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23692254
71LXR_22292898_ChIP-Seq_THP-1_Human1.23449914
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22900191
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22529492
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.22238053
75P68_20966046_ChIP-Seq_HELA_Human1.20954021
76SMC4_20622854_ChIP-Seq_HELA_Human1.20903333
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.20760793
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20278613
79* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19172831
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18287372
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18101424
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17512733
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17467829
84* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14826092
85GATA3_27048872_Chip-Seq_THYMUS_Human1.14386385
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.13606613
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13254184
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13254184
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12866109
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11747389
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09774822
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08718895
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.08620149
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07815550
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07181901
96VDR_24787735_ChIP-Seq_THP-1_Human1.06277603
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.05984663
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05856441
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05190919
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04311719
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02814817
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02146276
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02024519
104BCOR_27268052_Chip-Seq_Bcells_Human1.01726780
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00957478
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.00135458
107NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99964943
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99346771
109CBX2_27304074_Chip-Seq_ESCs_Mouse0.98047789
110NCOR1_26117541_ChIP-Seq_K562_Human0.97991407
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97232128
112JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97125956
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96961441
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95852423
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95268932
116FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95165204
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94046927
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.93269007
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93131108
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93045887
121AR_21572438_ChIP-Seq_LNCaP_Human0.92979023
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92501410
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90393889
124* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90186856
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89081090
126TET1_21451524_ChIP-Seq_MESCs_Mouse0.87745269
127RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87529013
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86494593
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85069791
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84382958
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82361512
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82310424
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.81907206
134GATA1_19941826_ChIP-Seq_K562_Human0.81619470
135SMAD_19615063_ChIP-ChIP_OVARY_Human0.81571631
136CREB1_26743006_Chip-Seq_LNCaP_Human0.81351557
137PU_27001747_Chip-Seq_BMDM_Mouse0.81286596
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79266606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.31582188
2MP0003303_peritoneal_inflammation3.28371593
3MP0000566_synostosis2.83341983
4MP0005409_darkened_coat_color2.49790551
5MP0005174_abnormal_tail_pigmentation2.41082546
6MP0003705_abnormal_hypodermis_morpholog2.39803274
7MP0003763_abnormal_thymus_physiology2.39368214
8MP0009278_abnormal_bone_marrow2.35575594
9MP0001790_abnormal_immune_system2.15953851
10MP0005387_immune_system_phenotype2.15953851
11MP0005451_abnormal_body_composition2.15161248
12MP0001873_stomach_inflammation2.08817373
13MP0008260_abnormal_autophagy2.08547608
14MP0004947_skin_inflammation2.01373199
15MP0004510_myositis2.00440985
16MP0003300_gastrointestinal_ulcer1.97312039
17MP0009379_abnormal_foot_pigmentation1.96342140
18MP0004381_abnormal_hair_follicle1.93220322
19MP0001800_abnormal_humoral_immune1.91634109
20MP0003724_increased_susceptibility_to1.90934768
21MP0005671_abnormal_response_to1.88849781
22MP0002396_abnormal_hematopoietic_system1.73509848
23MP0000703_abnormal_thymus_morphology1.72561612
24MP0000685_abnormal_immune_system1.71069980
25MP0003191_abnormal_cellular_cholesterol1.65377473
26MP0003172_abnormal_lysosome_physiology1.64789720
27MP0002398_abnormal_bone_marrow1.64648186
28MP0003866_abnormal_defecation1.62362600
29MP0003436_decreased_susceptibility_to1.60531365
30MP0002132_abnormal_respiratory_system1.59989931
31MP0003787_abnormal_imprinting1.58826119
32MP0001346_abnormal_lacrimal_gland1.57990483
33MP0000465_gastrointestinal_hemorrhage1.57686994
34MP0009333_abnormal_splenocyte_physiolog1.55065289
35MP0005000_abnormal_immune_tolerance1.53537207
36MP0008961_abnormal_basal_metabolism1.52161313
37MP0002723_abnormal_immune_serum1.49155964
38MP0005248_abnormal_Harderian_gland1.48581609
39MP0001835_abnormal_antigen_presentation1.47602686
40MP0001533_abnormal_skeleton_physiology1.47300102
41MP0002452_abnormal_antigen_presenting1.46938743
42MP0002420_abnormal_adaptive_immunity1.46373107
43MP0003828_pulmonary_edema1.45760729
44MP0001819_abnormal_immune_cell1.45594854
45MP0004185_abnormal_adipocyte_glucose1.45338912
46MP0004808_abnormal_hematopoietic_stem1.45115955
47MP0003091_abnormal_cell_migration1.44593384
48MP0002277_abnormal_respiratory_mucosa1.44046626
49MP0002405_respiratory_system_inflammati1.44016991
50MP0004742_abnormal_vestibular_system1.42155575
51MP0000569_abnormal_digit_pigmentation1.42076432
52MP0003136_yellow_coat_color1.41165975
53MP0001188_hyperpigmentation1.38269815
54MP0005257_abnormal_intraocular_pressure1.38103983
55MP0008995_early_reproductive_senescence1.37962180
56MP0000716_abnormal_immune_system1.36455252
57MP0002722_abnormal_immune_system1.28639947
58MP0004858_abnormal_nervous_system1.27732706
59MP0002998_abnormal_bone_remodeling1.27731165
60MP0005076_abnormal_cell_differentiation1.26890937
61MP0000015_abnormal_ear_pigmentation1.25941704
62MP0005025_abnormal_response_to1.25170600
63MP0002009_preneoplasia1.22718526
64MP0000689_abnormal_spleen_morphology1.21537297
65MP0002249_abnormal_larynx_morphology1.20185757
66MP0000613_abnormal_salivary_gland1.19824765
67MP0004233_abnormal_muscle_weight1.17377793
68MP0000049_abnormal_middle_ear1.16701195
69MP0001348_abnormal_lacrimal_gland1.16137046
70MP0003938_abnormal_ear_development1.14996086
71MP0005397_hematopoietic_system_phenotyp1.14558797
72MP0001545_abnormal_hematopoietic_system1.14558797
73MP0002938_white_spotting1.12978253
74MP0003045_fibrosis1.12312374
75MP0003385_abnormal_body_wall1.10978585
76MP0003453_abnormal_keratinocyte_physiol1.10970521
77MP0004264_abnormal_extraembryonic_tissu1.10656188
78MP0001845_abnormal_inflammatory_respons1.09600974
79MP0008789_abnormal_olfactory_epithelium1.09121993
80MP0005058_abnormal_lysosome_morphology1.07874051
81MP0002166_altered_tumor_susceptibility1.07677458
82MP0002429_abnormal_blood_cell1.07281634
83MP0001849_ear_inflammation1.06781176
84MP0000733_abnormal_muscle_development1.06628310
85MP0010155_abnormal_intestine_physiology1.05035148
86MP0002138_abnormal_hepatobiliary_system1.03371066
87MP0003935_abnormal_craniofacial_develop1.03315584
88MP0003279_aneurysm1.03165728
89MP0005310_abnormal_salivary_gland0.99930773
90MP0003566_abnormal_cell_adhesion0.99678906
91MP0005666_abnormal_adipose_tissue0.99358594
92MP0000490_abnormal_crypts_of0.97501292
93MP0009250_abnormal_appendicular_skeleto0.96926417
94MP0004883_abnormal_blood_vessel0.95422505
95MP0005394_taste/olfaction_phenotype0.94863078
96MP0005499_abnormal_olfactory_system0.94863078
97MP0002148_abnormal_hypersensitivity_rea0.94655976
98MP0000003_abnormal_adipose_tissue0.93082648
99MP0005464_abnormal_platelet_physiology0.92492770
100MP0002419_abnormal_innate_immunity0.91075130
101MP0002006_tumorigenesis0.90482583
102MP0002177_abnormal_outer_ear0.89301888
103MP0000767_abnormal_smooth_muscle0.86729918
104MP0001851_eye_inflammation0.86590182
105MP0005375_adipose_tissue_phenotype0.85979345
106MP0002796_impaired_skin_barrier0.85867236
107MP0005621_abnormal_cell_physiology0.85233906
108MP0002095_abnormal_skin_pigmentation0.84904071
109MP0006082_CNS_inflammation0.84419872
110MP0000470_abnormal_stomach_morphology0.84229993
111MP0002116_abnormal_craniofacial_bone0.83669611
112MP0002102_abnormal_ear_morphology0.82399858
113MP0000678_abnormal_parathyroid_gland0.81896647
114MP0005075_abnormal_melanosome_morpholog0.81621802
115MP0003448_altered_tumor_morphology0.81301149
116MP0008057_abnormal_DNA_replication0.80247674
117MP0001286_abnormal_eye_development0.79189326
118MP0001853_heart_inflammation0.78862757
119MP0003755_abnormal_palate_morphology0.78624985
120MP0001663_abnormal_digestive_system0.77589797
121MP0008469_abnormal_protein_level0.76779134
122MP0004130_abnormal_muscle_cell0.75176194
123MP0005390_skeleton_phenotype0.74852702
124MP0001986_abnormal_taste_sensitivity0.74310087
125MP0002933_joint_inflammation0.73296116
126MP0000631_abnormal_neuroendocrine_gland0.73046223
127MP0009115_abnormal_fat_cell0.73000197
128MP0003941_abnormal_skin_development0.72994103
129MP0009785_altered_susceptibility_to0.72139428
130MP0009840_abnormal_foam_cell0.72124147
131MP0000858_altered_metastatic_potential0.71050518
132MP0003119_abnormal_digestive_system0.71010727
133MP0009931_abnormal_skin_appearance0.70789151
134MP0000428_abnormal_craniofacial_morphol0.70553646
135MP0001784_abnormal_fluid_regulation0.70374860
136MP0000432_abnormal_head_morphology0.70198661
137MP0002092_abnormal_eye_morphology0.69428570
138MP0002697_abnormal_eye_size0.68703290
139MP0002254_reproductive_system_inflammat0.68457156
140MP0002019_abnormal_tumor_incidence0.65310033
141MP0002970_abnormal_white_adipose0.65060645
142MP0003183_abnormal_peptide_metabolism0.64214438

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.51358451
2Agammaglobulinemia (HP:0004432)3.41454555
3Broad face (HP:0000283)3.18978645
4Panhypogammaglobulinemia (HP:0003139)3.17086321
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.13837254
6Obstructive lung disease (HP:0006536)2.98419804
7Chronic obstructive pulmonary disease (HP:0006510)2.98419804
8Myositis (HP:0100614)2.91172771
9Recurrent cutaneous fungal infections (HP:0011370)2.90624574
10Chronic mucocutaneous candidiasis (HP:0002728)2.90624574
11Long eyelashes (HP:0000527)2.86044526
12Meningitis (HP:0001287)2.82617842
13Obstructive sleep apnea (HP:0002870)2.78014152
14Prolonged bleeding time (HP:0003010)2.74078077
15Recurrent fungal infections (HP:0002841)2.73965171
16Abnormality of macrophages (HP:0004311)2.70120713
17Pustule (HP:0200039)2.65233128
18Gastrointestinal infarctions (HP:0005244)2.62934411
19Elevated erythrocyte sedimentation rate (HP:0003565)2.62196561
20Cellulitis (HP:0100658)2.55919001
21Abnormality of DNA repair (HP:0003254)2.53626586
22Abnormality of the intervertebral disk (HP:0005108)2.52795636
23Supernumerary ribs (HP:0005815)2.52248383
24Orchitis (HP:0100796)2.49672300
25Abnormality of the columella (HP:0009929)2.47946172
26Dislocated radial head (HP:0003083)2.44152614
27Narrow palate (HP:0000189)2.41587388
28Cerebral aneurysm (HP:0004944)2.38064895
29Recurrent viral infections (HP:0004429)2.35167668
30Abnormality of the radial head (HP:0003995)2.33254356
31Slow saccadic eye movements (HP:0000514)2.28998433
32Supernumerary bones of the axial skeleton (HP:0009144)2.28488685
33Spinal cord lesions (HP:0100561)2.28435878
34Syringomyelia (HP:0003396)2.28435878
35Anal stenosis (HP:0002025)2.25396498
36Lip pit (HP:0100267)2.25174671
37Disproportionate tall stature (HP:0001519)2.24028312
38Eczematoid dermatitis (HP:0000976)2.23909994
39Inflammation of the large intestine (HP:0002037)2.23722967
40T lymphocytopenia (HP:0005403)2.21767913
41Optic neuritis (HP:0100653)2.18960938
42Retrobulbar optic neuritis (HP:0100654)2.18960938
43Thyroiditis (HP:0100646)2.17272437
44Recurrent gram-negative bacterial infections (HP:0005420)2.15467868
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15256861
46Intestinal fistula (HP:0100819)2.14462990
47Ectopic kidney (HP:0000086)2.10801665
48Cheilitis (HP:0100825)2.09964766
49Abnormality of the metopic suture (HP:0005556)2.09498532
50Abnormal number of incisors (HP:0011064)2.07928737
51Midline defect of the nose (HP:0004122)2.07887659
52Rib fusion (HP:0000902)2.07648045
53Sparse lateral eyebrow (HP:0005338)2.07353229
54Hyperacusis (HP:0010780)2.06575394
55Chest pain (HP:0100749)2.05557143
56Ureteral stenosis (HP:0000071)2.05349019
57Gastrointestinal inflammation (HP:0004386)2.03451689
58Vasculitis (HP:0002633)2.02215563
59Sparse scalp hair (HP:0002209)2.02084126
60Thin bony cortex (HP:0002753)2.01744323
61Abnormality of T cell number (HP:0011839)2.01114041
62Subacute progressive viral hepatitis (HP:0006572)1.98890693
63Stomatitis (HP:0010280)1.97976132
64Severe combined immunodeficiency (HP:0004430)1.97337404
65Ureteral obstruction (HP:0006000)1.96936767
66Segmental peripheral demyelination/remyelination (HP:0003481)1.96754950
67Abnormality of the parietal bone (HP:0002696)1.94805937
68Verrucae (HP:0200043)1.94254232
69Papilloma (HP:0012740)1.94254232
70Hypochromic anemia (HP:0001931)1.91726687
71Abnormal sex determination (HP:0012244)1.88974310
72Sex reversal (HP:0012245)1.88974310
73Trigonocephaly (HP:0000243)1.88239497
74Colitis (HP:0002583)1.88075847
75Acute lymphatic leukemia (HP:0006721)1.87793748
76Spontaneous hematomas (HP:0007420)1.87483454
77Recurrent abscess formation (HP:0002722)1.87333891
78Mediastinal lymphadenopathy (HP:0100721)1.87185225
79Gingivitis (HP:0000230)1.84894729
80Long palpebral fissure (HP:0000637)1.83317445
81Abnormality of the distal phalanx of the thumb (HP:0009617)1.81950032
82Emphysema (HP:0002097)1.81715726
83Chin dimple (HP:0010751)1.80980273
84Viral hepatitis (HP:0006562)1.80707772
85Genetic anticipation (HP:0003743)1.80025026
86Short 4th metacarpal (HP:0010044)1.79972399
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79972399
88Prominent metopic ridge (HP:0005487)1.79821515
89Arnold-Chiari malformation (HP:0002308)1.79614396
90Granulocytopenia (HP:0001913)1.79121693
91Abnormality of eosinophils (HP:0001879)1.77593032
92Shallow orbits (HP:0000586)1.77334862
93Eosinophilia (HP:0001880)1.76776660
94Abnormality of the thoracic spine (HP:0100711)1.76652891
95Germ cell neoplasia (HP:0100728)1.76572690
96Aneurysm (HP:0002617)1.76571002
97Abnormality of the nasal septum (HP:0000419)1.76569455
98Neonatal hypoglycemia (HP:0001998)1.76338432
99Polygenic inheritance (HP:0010982)1.76289856
100Encephalitis (HP:0002383)1.75904028
101Abnormality of T cells (HP:0002843)1.75402792
102Annular pancreas (HP:0001734)1.75305786
103Hemorrhage of the eye (HP:0011885)1.75090521
104Fatigue (HP:0012378)1.75030857
105Spina bifida occulta (HP:0003298)1.75016542
106Poikiloderma (HP:0001029)1.73546226
107Tented upper lip vermilion (HP:0010804)1.73453952
108Keratoconjunctivitis sicca (HP:0001097)1.73121011
109Flat acetabular roof (HP:0003180)1.72950438
110Increased IgE level (HP:0003212)1.72028511
111Menorrhagia (HP:0000132)1.72011890
112Autoimmune thrombocytopenia (HP:0001973)1.71853719
113Asymmetry of the thorax (HP:0001555)1.71411446
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70596006
115Dilatation of the ascending aorta (HP:0005111)1.69866003
116Leukocytosis (HP:0001974)1.69797124
117Aplasia cutis congenita (HP:0001057)1.69785304
118Increased density of long bones (HP:0006392)1.68487612
119Hemoptysis (HP:0002105)1.68359040
120Osteomyelitis (HP:0002754)1.68320245
121Easy fatigability (HP:0003388)1.68192469
122Lymphopenia (HP:0001888)1.67915225
123Dysmetric saccades (HP:0000641)1.67766434
124Urethral obstruction (HP:0000796)1.67680715
125Clubbing of toes (HP:0100760)1.66888287
126Large earlobe (HP:0009748)1.66753947
127Thoracic kyphosis (HP:0002942)1.65618802
128Morphological abnormality of the middle ear (HP:0008609)1.65493351
129Persistence of primary teeth (HP:0006335)1.65436472
130Cutis marmorata (HP:0000965)1.65362281
131Genu recurvatum (HP:0002816)1.65092618
132Recurrent skin infections (HP:0001581)1.64889018
133Dysostosis multiplex (HP:0000943)1.64292100
134Uterine leiomyosarcoma (HP:0002891)1.64222893
135Leiomyosarcoma (HP:0100243)1.64222893
136Epistaxis (HP:0000421)1.63570560
137Entropion (HP:0000621)1.62971804
138Metaphyseal cupping (HP:0003021)1.62851006
139Atelectasis (HP:0100750)1.62044410
140Urinary glycosaminoglycan excretion (HP:0003541)1.61945369
141Mucopolysacchariduria (HP:0008155)1.61945369
142Unilateral renal agenesis (HP:0000122)1.61877735
143Depressed nasal tip (HP:0000437)1.61236275
144Patellar dislocation (HP:0002999)1.61008437
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.60976483
146Triphalangeal thumb (HP:0001199)1.58886964
147Recurrent bacterial skin infections (HP:0005406)1.57948087
148Abnormally folded helix (HP:0008544)1.57460761
149Anal atresia (HP:0002023)1.56641965
150Slow-growing hair (HP:0002217)1.55245553
151Abnormality of hair growth rate (HP:0011363)1.55245553
152Submucous cleft hard palate (HP:0000176)1.55003934
153Transitional cell carcinoma of the bladder (HP:0006740)1.54692189
154Sleep apnea (HP:0010535)1.54268631
155Porencephaly (HP:0002132)1.53422928
156Combined immunodeficiency (HP:0005387)1.51848033
157Bladder carcinoma (HP:0002862)1.51656860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.64782177
2MKNK23.21584500
3CDK123.02245959
4MAP4K12.81446989
5IRAK22.58016726
6SMG12.46620594
7RIPK42.40064273
8PRKD22.35682214
9SIK22.27614818
10CLK12.24104743
11IRAK42.17443071
12TXK2.06678259
13MAP3K102.06511300
14TNK22.00446083
15FES1.99894623
16IRAK31.92408276
17BLK1.89304227
18MAP2K31.87283976
19BRD41.86668447
20CASK1.82190212
21TLK11.81569083
22IRAK11.71014438
23PRPF4B1.67411289
24NLK1.66956506
25DMPK1.65786346
26TAOK31.63281919
27MAP3K31.63017852
28MKNK11.61753456
29HIPK21.61621964
30CSK1.54177302
31MAP3K131.42381142
32EPHA31.32984647
33CDK91.32493012
34EPHB11.28913815
35MARK21.23664398
36UHMK11.19170862
37HCK1.18650997
38RIPK11.18554204
39IKBKE1.16644649
40STK111.15256923
41PKN21.14888928
42BTK1.12065979
43TAOK11.11185814
44JAK31.09539639
45INSRR1.03776388
46YES11.01734371
47ICK1.01431855
48FGFR31.00921370
49MAP3K11.00609036
50CAMKK10.95203154
51MAP3K20.95044705
52SIK30.93122641
53CAMK1G0.91225585
54LCK0.90879248
55CHUK0.90710179
56MAP3K140.90566418
57MAPK150.89182961
58TTN0.88077210
59KSR20.87040041
60BMX0.86396351
61ALK0.85960421
62DYRK1B0.85576520
63ZAP700.85008688
64MAPK70.84901105
65MAPK120.83361480
66TNIK0.83320566
67MELK0.80755381
68TBK10.80625521
69RPS6KC10.78423716
70RPS6KL10.78423716
71SYK0.78209378
72ERN10.78093861
73NUAK10.74798457
74STK40.74138920
75PIM10.73768999
76CDK70.73349486
77RPS6KA60.73291399
78STK100.73223080
79WNK10.71878041
80MAP3K70.71596659
81MAP3K110.70649424
82CDK30.70509498
83CDC42BPA0.70255484
84PDK10.68440148
85GRK60.68302987
86ITK0.66468662
87PKN10.66254949
88JAK10.66079870
89PDPK10.65982058
90CAMK40.65422096
91PRKD10.64677586
92IKBKB0.64155626
93PASK0.63356961
94RPS6KA20.61952335
95DYRK30.61783707
96RET0.61590031
97TYRO30.61411915
98MAPK110.61003838
99PDGFRB0.58734316
100EEF2K0.58661808
101PRKAA20.58659544
102TAOK20.58450658
103TYK20.57915479
104SIK10.57210060
105PTK60.55793652
106CDK60.55688676
107KIT0.55310836
108CDK40.54497216
109LYN0.53592400
110STK240.53182394
111FGFR40.52938210
112SRPK10.50617476
113TEC0.50476968
114SGK30.50169021
115TGFBR20.50060744
116GRK10.47987685
117MAP3K60.47005730
118MARK30.46565668
119STK380.46180331
120MAP2K20.46038911
121RPS6KA50.45143518
122ERBB20.45093812
123FGR0.44406283
124SGK20.43831870
125MTOR0.43821351
126CAMK1D0.43444946
127JAK20.43010956
128AKT10.42416013
129RPS6KA40.42132904
130CSF1R0.40625370
131RPS6KA10.40124365
132LRRK20.40024144
133TRPM70.39706473

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.62328037
2Notch signaling pathway_Homo sapiens_hsa043301.96152932
3Acute myeloid leukemia_Homo sapiens_hsa052211.90755163
4B cell receptor signaling pathway_Homo sapiens_hsa046621.83371563
5T cell receptor signaling pathway_Homo sapiens_hsa046601.73967339
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64966159
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.61452079
8Chronic myeloid leukemia_Homo sapiens_hsa052201.60501558
9Osteoclast differentiation_Homo sapiens_hsa043801.55405042
10Measles_Homo sapiens_hsa051621.46770581
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44143157
12* Lysine degradation_Homo sapiens_hsa003101.43845510
13mTOR signaling pathway_Homo sapiens_hsa041501.41596191
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40350602
15Hematopoietic cell lineage_Homo sapiens_hsa046401.39334080
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.38959619
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36905160
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36228721
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36220766
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.34151306
21Other glycan degradation_Homo sapiens_hsa005111.34111283
22Leishmaniasis_Homo sapiens_hsa051401.25177394
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23750563
24Chemokine signaling pathway_Homo sapiens_hsa040621.21952176
25Prostate cancer_Homo sapiens_hsa052151.19960163
26MicroRNAs in cancer_Homo sapiens_hsa052061.18028914
27Basal cell carcinoma_Homo sapiens_hsa052171.17632271
28Herpes simplex infection_Homo sapiens_hsa051681.14872664
29Fanconi anemia pathway_Homo sapiens_hsa034601.13961427
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13424006
31Endometrial cancer_Homo sapiens_hsa052131.13337252
32Non-small cell lung cancer_Homo sapiens_hsa052231.12296448
33Thyroid cancer_Homo sapiens_hsa052161.11188320
34Viral myocarditis_Homo sapiens_hsa054161.09602836
35Hepatitis B_Homo sapiens_hsa051611.07968586
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07185507
37mRNA surveillance pathway_Homo sapiens_hsa030151.06511735
38Prolactin signaling pathway_Homo sapiens_hsa049171.06009897
39ErbB signaling pathway_Homo sapiens_hsa040121.05087732
40Renal cell carcinoma_Homo sapiens_hsa052111.03130202
41Platelet activation_Homo sapiens_hsa046111.02860970
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99908479
43Axon guidance_Homo sapiens_hsa043600.98291273
44Wnt signaling pathway_Homo sapiens_hsa043100.97882702
45Pancreatic cancer_Homo sapiens_hsa052120.97498201
46Insulin resistance_Homo sapiens_hsa049310.96777833
47GnRH signaling pathway_Homo sapiens_hsa049120.96559174
48Insulin signaling pathway_Homo sapiens_hsa049100.95942729
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.94535869
50Graft-versus-host disease_Homo sapiens_hsa053320.94093471
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92530538
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92232510
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91935877
54Colorectal cancer_Homo sapiens_hsa052100.90883771
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89662658
56Choline metabolism in cancer_Homo sapiens_hsa052310.88937422
57Dorso-ventral axis formation_Homo sapiens_hsa043200.88605995
58Influenza A_Homo sapiens_hsa051640.88575654
59Autoimmune thyroid disease_Homo sapiens_hsa053200.88001237
60Type II diabetes mellitus_Homo sapiens_hsa049300.85777313
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85347188
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84851216
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84167448
64Estrogen signaling pathway_Homo sapiens_hsa049150.84116747
65MAPK signaling pathway_Homo sapiens_hsa040100.83483410
66Toxoplasmosis_Homo sapiens_hsa051450.82905652
67VEGF signaling pathway_Homo sapiens_hsa043700.81855482
68HTLV-I infection_Homo sapiens_hsa051660.81532453
69Spliceosome_Homo sapiens_hsa030400.81407998
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.81221303
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80093493
72Viral carcinogenesis_Homo sapiens_hsa052030.79334455
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79313420
74Long-term potentiation_Homo sapiens_hsa047200.78841742
75FoxO signaling pathway_Homo sapiens_hsa040680.78344770
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.76918304
77Pathways in cancer_Homo sapiens_hsa052000.76690446
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75112525
79Small cell lung cancer_Homo sapiens_hsa052220.75086238
80Bladder cancer_Homo sapiens_hsa052190.74542122
81Antigen processing and presentation_Homo sapiens_hsa046120.73836813
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.73622116
83Glioma_Homo sapiens_hsa052140.73541100
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73150768
85Endocytosis_Homo sapiens_hsa041440.73058232
86Amoebiasis_Homo sapiens_hsa051460.72581644
87Epstein-Barr virus infection_Homo sapiens_hsa051690.72420193
88Melanoma_Homo sapiens_hsa052180.72256356
89HIF-1 signaling pathway_Homo sapiens_hsa040660.71088817
90Phototransduction_Homo sapiens_hsa047440.70324674
91AMPK signaling pathway_Homo sapiens_hsa041520.69431249
92Malaria_Homo sapiens_hsa051440.69304320
93Staphylococcus aureus infection_Homo sapiens_hsa051500.67632675
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67276670
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.67184678
96Adherens junction_Homo sapiens_hsa045200.67115669
97Allograft rejection_Homo sapiens_hsa053300.66385633
98Homologous recombination_Homo sapiens_hsa034400.65870796
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65055465
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64962562
101TNF signaling pathway_Homo sapiens_hsa046680.64903730
102Hedgehog signaling pathway_Homo sapiens_hsa043400.64832289
103Rap1 signaling pathway_Homo sapiens_hsa040150.63412272
104Tuberculosis_Homo sapiens_hsa051520.62644663
105Melanogenesis_Homo sapiens_hsa049160.62370671
106Ras signaling pathway_Homo sapiens_hsa040140.62224027
107Inositol phosphate metabolism_Homo sapiens_hsa005620.61737831
108Hepatitis C_Homo sapiens_hsa051600.61620878
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61477445
110Ribosome_Homo sapiens_hsa030100.61240909
111Long-term depression_Homo sapiens_hsa047300.60893586
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.59775136
113Apoptosis_Homo sapiens_hsa042100.58335768
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.57860463
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56822404
116Proteoglycans in cancer_Homo sapiens_hsa052050.55811899
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55639269
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55340444
119Focal adhesion_Homo sapiens_hsa045100.55123797
120Basal transcription factors_Homo sapiens_hsa030220.54943126
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54753389
122Asthma_Homo sapiens_hsa053100.54709749
123African trypanosomiasis_Homo sapiens_hsa051430.54511901
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54355263
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54316777
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53537059
127Shigellosis_Homo sapiens_hsa051310.53492696

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