SETD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.95353734
2mitotic sister chromatid cohesion (GO:0007064)5.77786227
3nuclear pore organization (GO:0006999)5.40340275
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.62383516
5monoubiquitinated protein deubiquitination (GO:0035520)4.52749180
6mitotic chromosome condensation (GO:0007076)4.48864544
7pore complex assembly (GO:0046931)4.41801559
8* regulation of RNA export from nucleus (GO:0046831)4.36609469
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23459045
10protein localization to kinetochore (GO:0034501)4.22593509
11* peptidyl-lysine trimethylation (GO:0018023)4.21262103
12regulation of spindle organization (GO:0090224)4.15121207
13establishment of protein localization to Golgi (GO:0072600)4.13382201
14pre-miRNA processing (GO:0031054)4.12798612
15regulation of mitotic spindle organization (GO:0060236)4.08182957
16positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.97195375
17positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.97195375
18positive regulation of mitotic sister chromatid separation (GO:1901970)3.97195375
19retrograde transport, vesicle recycling within Golgi (GO:0000301)3.91801623
20negative regulation of histone methylation (GO:0031061)3.89736527
21cytoplasmic mRNA processing body assembly (GO:0033962)3.87308695
22protein targeting to Golgi (GO:0000042)3.83424428
23regulation of DNA endoreduplication (GO:0032875)3.82297584
24nucleus localization (GO:0051647)3.76808282
25protein localization to chromosome, centromeric region (GO:0071459)3.68280458
26positive regulation of chromosome segregation (GO:0051984)3.64896886
27sister chromatid segregation (GO:0000819)3.64435001
28* regulation of nucleobase-containing compound transport (GO:0032239)3.59821209
29regulation of centriole replication (GO:0046599)3.58822353
30establishment of nucleus localization (GO:0040023)3.58678101
31regulation of histone H3-K9 methylation (GO:0051570)3.58182439
32* peptidyl-lysine methylation (GO:0018022)3.53280318
33mitotic metaphase plate congression (GO:0007080)3.48998332
34positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.48753925
35DNA topological change (GO:0006265)3.41411789
36mitotic nuclear envelope disassembly (GO:0007077)3.35017107
37regulation of sister chromatid cohesion (GO:0007063)3.33608320
38sister chromatid cohesion (GO:0007062)3.31788027
39negative regulation of DNA-dependent DNA replication (GO:2000104)3.30855458
40protein demethylation (GO:0006482)3.29324466
41protein dealkylation (GO:0008214)3.29324466
42negative regulation of fibroblast apoptotic process (GO:2000270)3.29269079
43histone H3-K36 demethylation (GO:0070544)3.23777207
44NLS-bearing protein import into nucleus (GO:0006607)3.22555867
45histone H2A monoubiquitination (GO:0035518)3.21411319
46kinetochore organization (GO:0051383)3.19606502
47N-terminal protein amino acid acetylation (GO:0006474)3.18649956
48membrane disassembly (GO:0030397)3.18443132
49nuclear envelope disassembly (GO:0051081)3.18443132
50metaphase plate congression (GO:0051310)3.16664003
51histone H3-K4 trimethylation (GO:0080182)3.16019795
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14517384
53regulation of NFAT protein import into nucleus (GO:0051532)3.14157089
54histone H3-K4 methylation (GO:0051568)3.12749649
55peptidyl-lysine dimethylation (GO:0018027)3.12727113
56regulation of protein polyubiquitination (GO:1902914)3.12047793
57histone deubiquitination (GO:0016578)3.10272519
58DNA synthesis involved in DNA repair (GO:0000731)3.08398323
59protein localization to chromosome (GO:0034502)3.07346220
60DNA unwinding involved in DNA replication (GO:0006268)3.06899430
61regulation of translation, ncRNA-mediated (GO:0045974)3.05988151
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.05988151
63negative regulation of translation, ncRNA-mediated (GO:0040033)3.05988151
64definitive hemopoiesis (GO:0060216)3.05374041
65positive regulation of DNA-templated transcription, initiation (GO:2000144)3.04024238
66histone H4-K16 acetylation (GO:0043984)3.03756895
67mitotic sister chromatid segregation (GO:0000070)3.02814775
68microtubule anchoring (GO:0034453)3.02605175
69regulation of histone H3-K27 methylation (GO:0061085)3.02317266
70histone mRNA catabolic process (GO:0071044)3.01920652
71DNA duplex unwinding (GO:0032508)3.01774748
72DNA geometric change (GO:0032392)3.01487480
73protein K48-linked deubiquitination (GO:0071108)2.98358571
74histone H3-K9 demethylation (GO:0033169)2.96383920
75positive regulation of granulocyte differentiation (GO:0030854)2.93967640
76peptidyl-threonine phosphorylation (GO:0018107)2.93934095
77genitalia morphogenesis (GO:0035112)2.92166516
78spindle checkpoint (GO:0031577)2.91497655
79negative regulation of DNA repair (GO:0045738)2.91122627
80Golgi to endosome transport (GO:0006895)2.90975968
81protein K11-linked deubiquitination (GO:0035871)2.90468459
82histone lysine demethylation (GO:0070076)2.88864435
83regulation of nuclear cell cycle DNA replication (GO:0033262)2.86955255
84dosage compensation (GO:0007549)2.86765811
85chromatin assembly (GO:0031497)2.86266599
86meiotic chromosome segregation (GO:0045132)2.83363138
87histone H3-K9 methylation (GO:0051567)2.82321752
88regulation of histone methylation (GO:0031060)2.81694325
89glucocorticoid receptor signaling pathway (GO:0042921)2.81617673
90regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80747479
91corticosteroid receptor signaling pathway (GO:0031958)2.79129516
92attachment of spindle microtubules to kinetochore (GO:0008608)2.79071382
93establishment of chromosome localization (GO:0051303)2.78966003
94chromosome condensation (GO:0030261)2.76049170
95interkinetic nuclear migration (GO:0022027)2.75771494
96regulation of chromosome segregation (GO:0051983)2.75580208
97DNA conformation change (GO:0071103)2.75216572
98positive regulation of developmental pigmentation (GO:0048087)2.75185875
99histone demethylation (GO:0016577)2.75022472
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74508089
101regulation of centrosome cycle (GO:0046605)2.74447050
102DNA packaging (GO:0006323)2.73251170
103positive regulation of gamma-delta T cell activation (GO:0046645)2.72806450
104synapsis (GO:0007129)2.71536201
105* histone methylation (GO:0016571)2.71483619
106regulation of centrosome duplication (GO:0010824)2.71459877
107chromatin assembly or disassembly (GO:0006333)2.71126952
108nucleus organization (GO:0006997)2.69568825
109cellular response to ethanol (GO:0071361)2.69547162
110phospholipid translocation (GO:0045332)2.69502124
111lipid translocation (GO:0034204)2.69502124
112peptidyl-threonine modification (GO:0018210)2.69227992
113regulation of pigment cell differentiation (GO:0050932)2.68389174
114regulation of sister chromatid segregation (GO:0033045)2.68153851
115regulation of mitotic sister chromatid separation (GO:0010965)2.68153851
116regulation of mitotic sister chromatid segregation (GO:0033047)2.68153851
117regulation of fibroblast apoptotic process (GO:2000269)2.67624865
118RNA stabilization (GO:0043489)2.66783201
119mRNA stabilization (GO:0048255)2.66783201
120negative regulation of histone modification (GO:0031057)2.66661158
121mitotic spindle checkpoint (GO:0071174)2.66277639
122snRNA transcription (GO:0009301)2.66177887
123spindle assembly checkpoint (GO:0071173)2.64684375
124ATP-dependent chromatin remodeling (GO:0043044)2.64560914
125negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.62799948
126negative regulation of chromatin modification (GO:1903309)2.61673758
127embryonic camera-type eye morphogenesis (GO:0048596)2.61334581
128protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.60742663
129positive regulation of cell cycle checkpoint (GO:1901978)2.60142051
130centriole replication (GO:0007099)2.59877359
131embryonic retina morphogenesis in camera-type eye (GO:0060059)2.58442951
132histone H3-K9 modification (GO:0061647)2.56862868
133DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.56857685
134embryonic hemopoiesis (GO:0035162)2.55740033
135DNA replication-independent nucleosome organization (GO:0034724)2.55231475
136DNA replication-independent nucleosome assembly (GO:0006336)2.55231475
137hepatocyte apoptotic process (GO:0097284)2.54948060
138gene silencing by RNA (GO:0031047)2.54471298
139nuclear envelope organization (GO:0006998)2.54424714
140positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53984195
141regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53984195
142regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.53808393
143positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.53808393
144* histone lysine methylation (GO:0034968)2.53452731
145nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52029505
146neural tube formation (GO:0001841)2.47700046
147TOR signaling (GO:0031929)2.46096942
148protein K63-linked deubiquitination (GO:0070536)2.44815172
149regulation of establishment of cell polarity (GO:2000114)2.42632083
150growth hormone receptor signaling pathway (GO:0060396)2.42530233
151protein deubiquitination (GO:0016579)2.42228531
152regulation of granulocyte differentiation (GO:0030852)2.41450765
153positive regulation of gene expression, epigenetic (GO:0045815)2.38114988
154histone acetylation (GO:0016573)2.37745237
155protein localization to Golgi apparatus (GO:0034067)2.35675530
156regulation of B cell receptor signaling pathway (GO:0050855)2.35509331
157histone H4 acetylation (GO:0043967)2.33057340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23251959
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.70391899
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.58929873
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00403907
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.81861008
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.38932181
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.11916781
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07195187
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94662914
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.91958918
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81530771
12MYC_22102868_ChIP-Seq_BL_Human2.69215100
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66627557
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.40183871
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37476369
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13464790
17GATA1_22025678_ChIP-Seq_K562_Human1.96153995
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92801046
19AR_21909140_ChIP-Seq_LNCAP_Human1.90661868
20CIITA_25753668_ChIP-Seq_RAJI_Human1.85985106
21TCF7_22412390_ChIP-Seq_EML_Mouse1.78915645
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73890952
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73252422
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73023494
25TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.72633581
26GBX2_23144817_ChIP-Seq_PC3_Human1.72387202
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72237184
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71945715
29TAF15_26573619_Chip-Seq_HEK293_Human1.71571246
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69041444
31* STAT3_23295773_ChIP-Seq_U87_Human1.66984027
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66947906
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66947906
34PKCTHETA_26484144_Chip-Seq_BREAST_Human1.65196075
35FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.65087737
36AR_21572438_ChIP-Seq_LNCaP_Human1.62168367
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61762742
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60682914
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60457680
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59831751
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.56219550
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53618020
43SMAD4_21799915_ChIP-Seq_A2780_Human1.52880257
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51662238
45TCF4_23295773_ChIP-Seq_U87_Human1.48941189
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.48369019
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47110865
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.45909483
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45771917
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44355812
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41389566
52MYB_26560356_Chip-Seq_TH1_Human1.40303345
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39546699
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38906097
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34685491
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34522477
57ER_23166858_ChIP-Seq_MCF-7_Human1.33295664
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.31726629
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31066681
60AHR_22903824_ChIP-Seq_MCF-7_Human1.30690881
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30370920
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28791260
63MYB_26560356_Chip-Seq_TH2_Human1.27283703
64BRD4_25478319_ChIP-Seq_HGPS_Human1.26495844
65P300_19829295_ChIP-Seq_ESCs_Human1.26216966
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25732569
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.24914369
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23691892
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23440596
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21680883
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19482050
72VDR_21846776_ChIP-Seq_THP-1_Human1.19201855
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16818560
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16452905
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15111632
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.15022201
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14765235
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.14508192
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.14352022
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14262065
81UTX_26944678_Chip-Seq_JUKART_Human1.14162401
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.13608460
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12994117
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12694394
85KDM2B_26808549_Chip-Seq_DND41_Human1.12637347
86SCL_19346495_ChIP-Seq_HPC-7_Human1.12602901
87* KDM5A_27292631_Chip-Seq_BREAST_Human1.12562892
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12339269
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11707780
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.11139006
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10824687
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.10527677
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.09378698
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08999663
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08835798
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.08381316
97MAF_26560356_Chip-Seq_TH1_Human1.08092178
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07736542
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07470078
100CBP_20019798_ChIP-Seq_JUKART_Human1.07197198
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07197198
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06116071
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.04978559
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04407669
105BCAT_22108803_ChIP-Seq_LS180_Human1.04188693
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04119802
107FOXA2_19822575_ChIP-Seq_HepG2_Human1.02355588
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.01208048
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.01132785
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00236660
111TP53_16413492_ChIP-PET_HCT116_Human1.00002646
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99485510
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99290463
114EWS_26573619_Chip-Seq_HEK293_Human0.98817970
115FLI1_21867929_ChIP-Seq_TH2_Mouse0.98501072
116RUNX2_22187159_ChIP-Seq_PCA_Human0.98467559
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98021252
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97854050
119RXR_22108803_ChIP-Seq_LS180_Human0.97097100
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96979199
121* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96918118
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96720446
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96595116
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96489645
125RUNX_20019798_ChIP-Seq_JUKART_Human0.96322318
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96266791
127* CHD1_26751641_Chip-Seq_LNCaP_Human0.96145130
128RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96128946
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95171986
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95164290
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95140537
132IGF1R_20145208_ChIP-Seq_DFB_Human0.95130627
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94430371
134BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93257394
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92837878
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.92412376
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.90915896
138NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90872661
139ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89285414
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.88919240
141SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86263894
142ELK1_19687146_ChIP-ChIP_HELA_Human0.85072510
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84861975
144NCOR1_26117541_ChIP-Seq_K562_Human0.83446106
145MYC_19079543_ChIP-ChIP_MESCs_Mouse0.82595974
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82471298
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81478368
148* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81270395
149IRF8_27001747_Chip-Seq_BMDM_Mouse0.80611637
150SPI1_23547873_ChIP-Seq_NB4_Human0.80199474
151SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79381849
152SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79381849
153TFEB_21752829_ChIP-Seq_HELA_Human0.79301123
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78527658
155GATA3_27048872_Chip-Seq_THYMUS_Human0.78389792
156* RUNX1_22412390_ChIP-Seq_EML_Mouse0.78179113
157SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76874324
158VDR_24763502_ChIP-Seq_THP-1_Human0.76697384
159FUS_26573619_Chip-Seq_HEK293_Human0.76633953
160POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.74855146
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74669770
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74141138
163SPI1_23127762_ChIP-Seq_K562_Human0.74061645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.96184968
2MP0000569_abnormal_digit_pigmentation3.75866644
3MP0010094_abnormal_chromosome_stability3.31216882
4MP0003111_abnormal_nucleus_morphology3.01075200
5MP0003077_abnormal_cell_cycle2.90072043
6MP0005076_abnormal_cell_differentiation2.85692961
7MP0002396_abnormal_hematopoietic_system2.70374324
8MP0003693_abnormal_embryo_hatching2.64292004
9MP0010307_abnormal_tumor_latency2.56567832
10MP0010352_gastrointestinal_tract_polyps2.52952379
11MP0004808_abnormal_hematopoietic_stem2.48148213
12MP0008007_abnormal_cellular_replicative2.30132101
13MP0008877_abnormal_DNA_methylation2.11627647
14MP0008058_abnormal_DNA_repair2.03901803
15MP0003787_abnormal_imprinting1.98316285
16MP0003121_genomic_imprinting1.87839028
17MP0000350_abnormal_cell_proliferation1.87019303
18MP0004957_abnormal_blastocyst_morpholog1.83743893
19MP0002166_altered_tumor_susceptibility1.76984032
20MP0001730_embryonic_growth_arrest1.76247376
21MP0009278_abnormal_bone_marrow1.72444429
22* MP0005380_embryogenesis_phenotype1.70160804
23* MP0001672_abnormal_embryogenesis/_devel1.70160804
24MP0010234_abnormal_vibrissa_follicle1.66593038
25* MP0003984_embryonic_growth_retardation1.65718064
26MP0005409_darkened_coat_color1.63931206
27* MP0002088_abnormal_embryonic_growth/wei1.63478342
28* MP0002086_abnormal_extraembryonic_tissu1.62411062
29MP0004197_abnormal_fetal_growth/weight/1.58647335
30* MP0002084_abnormal_developmental_patter1.54298199
31MP0001545_abnormal_hematopoietic_system1.50626614
32MP0005397_hematopoietic_system_phenotyp1.50626614
33MP0003890_abnormal_embryonic-extraembry1.47610510
34MP0005310_abnormal_salivary_gland1.45974136
35MP0009703_decreased_birth_body1.45802535
36MP0002006_tumorigenesis1.43130872
37MP0003705_abnormal_hypodermis_morpholog1.43110228
38MP0001697_abnormal_embryo_size1.42711007
39MP0000703_abnormal_thymus_morphology1.42363972
40MP0000015_abnormal_ear_pigmentation1.42045426
41MP0004264_abnormal_extraembryonic_tissu1.39402239
42MP0002009_preneoplasia1.39151644
43* MP0002085_abnormal_embryonic_tissue1.37479316
44MP0003123_paternal_imprinting1.36697777
45MP0000733_abnormal_muscle_development1.32581822
46MP0004381_abnormal_hair_follicle1.30052626
47MP0002398_abnormal_bone_marrow1.28106046
48MP0003300_gastrointestinal_ulcer1.20827932
49MP0008961_abnormal_basal_metabolism1.19732008
50MP0003763_abnormal_thymus_physiology1.19668899
51MP0003656_abnormal_erythrocyte_physiolo1.19212317
52MP0009697_abnormal_copulation1.18751733
53MP0010678_abnormal_skin_adnexa1.17468579
54MP0009672_abnormal_birth_weight1.17296726
55MP0002877_abnormal_melanocyte_morpholog1.15135975
56MP0000383_abnormal_hair_follicle1.12566038
57* MP0002080_prenatal_lethality1.12340048
58* MP0003935_abnormal_craniofacial_develop1.12060355
59MP0001915_intracranial_hemorrhage1.11709960
60MP0000490_abnormal_crypts_of1.09239756
61MP0000427_abnormal_hair_cycle1.08447386
62* MP0002925_abnormal_cardiovascular_devel1.07921382
63MP0003567_abnormal_fetal_cardiomyocyte1.07702590
64MP0001800_abnormal_humoral_immune1.06568495
65MP0000432_abnormal_head_morphology1.05100914
66MP0000428_abnormal_craniofacial_morphol1.04901195
67MP0003566_abnormal_cell_adhesion1.01126956
68MP0001849_ear_inflammation0.99432146
69MP0002722_abnormal_immune_system0.99426656
70MP0003786_premature_aging0.98500539
71MP0000313_abnormal_cell_death0.98141278
72MP0002019_abnormal_tumor_incidence0.97884885
73MP0009115_abnormal_fat_cell0.97607221
74MP0003091_abnormal_cell_migration0.97523309
75MP0003937_abnormal_limbs/digits/tail_de0.97476008
76MP0003868_abnormal_feces_composition0.97231094
77MP0001293_anophthalmia0.96243420
78MP0003943_abnormal_hepatobiliary_system0.95243481
79MP0005621_abnormal_cell_physiology0.94630596
80MP0003646_muscle_fatigue0.93357056
81MP0003115_abnormal_respiratory_system0.93058039
82MP0000516_abnormal_urinary_system0.92299699
83MP0005367_renal/urinary_system_phenotyp0.92299699
84MP0003828_pulmonary_edema0.91742624
85MP0000689_abnormal_spleen_morphology0.91361910
86MP0002092_abnormal_eye_morphology0.90671543
87MP0002928_abnormal_bile_duct0.90498577
88MP0000778_abnormal_nervous_system0.89954482
89MP0003045_fibrosis0.89901909
90MP0000716_abnormal_immune_system0.87831278
91MP0001929_abnormal_gametogenesis0.85911048
92MP0005174_abnormal_tail_pigmentation0.85622546
93MP0008932_abnormal_embryonic_tissue0.85343297
94MP0008995_early_reproductive_senescence0.84927841
95MP0005220_abnormal_exocrine_pancreas0.84200245
96MP0002452_abnormal_antigen_presenting0.82786053
97MP0009053_abnormal_anal_canal0.82520137
98MP0010630_abnormal_cardiac_muscle0.80848324
99MP0005671_abnormal_response_to0.80143878
100MP0000371_diluted_coat_color0.79656539
101MP0003172_abnormal_lysosome_physiology0.78661146
102MP0000767_abnormal_smooth_muscle0.78373028
103MP0000685_abnormal_immune_system0.78300681
104MP0002429_abnormal_blood_cell0.78171319
105MP0005248_abnormal_Harderian_gland0.77686176
106MP0002420_abnormal_adaptive_immunity0.76060694
107MP0004185_abnormal_adipocyte_glucose0.75343971
108MP0001835_abnormal_antigen_presentation0.74882060
109MP0003755_abnormal_palate_morphology0.73986815
110MP0001819_abnormal_immune_cell0.73760294
111MP0000627_abnormal_mammary_gland0.73330126
112MP0005023_abnormal_wound_healing0.72874116
113MP0005187_abnormal_penis_morphology0.72837628
114MP0005384_cellular_phenotype0.72734909
115MP0003221_abnormal_cardiomyocyte_apopto0.71806683
116MP0002210_abnormal_sex_determination0.70999776
117MP0000537_abnormal_urethra_morphology0.70835707
118MP0002168_other_aberrant_phenotype0.70704926
119* MP0000266_abnormal_heart_morphology0.70230108
120MP0003698_abnormal_male_reproductive0.70209555
121MP0004134_abnormal_chest_morphology0.69692851
122* MP0001784_abnormal_fluid_regulation0.69677131
123MP0003183_abnormal_peptide_metabolism0.69160522
124MP0004742_abnormal_vestibular_system0.68235743
125MP0001286_abnormal_eye_development0.67627918
126MP0001851_eye_inflammation0.67072260
127MP0001145_abnormal_male_reproductive0.64369666
128MP0002405_respiratory_system_inflammati0.63357132
129MP0001790_abnormal_immune_system0.61872561
130MP0005387_immune_system_phenotype0.61872561
131MP0001879_abnormal_lymphatic_vessel0.60820010
132MP0005666_abnormal_adipose_tissue0.60809703

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.67134802
2Volvulus (HP:0002580)4.44319559
3Short 4th metacarpal (HP:0010044)3.23541100
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.23541100
5Genetic anticipation (HP:0003743)3.13257937
6Long eyelashes (HP:0000527)3.06563647
7Chromsome breakage (HP:0040012)3.04059864
8Acute myeloid leukemia (HP:0004808)2.67619516
9Prominent nose (HP:0000448)2.67342200
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64462270
11Macroorchidism (HP:0000053)2.61439356
12Abnormal hair whorl (HP:0010721)2.60323738
13Ectopic kidney (HP:0000086)2.57808570
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.53421084
15Increased nuchal translucency (HP:0010880)2.53302239
16Abnormality of the ischium (HP:0003174)2.52584089
17Hepatoblastoma (HP:0002884)2.52209633
18Thyroid carcinoma (HP:0002890)2.51877296
19Narrow palate (HP:0000189)2.50659023
20Papillary thyroid carcinoma (HP:0002895)2.49514616
21Urethral obstruction (HP:0000796)2.49282083
22Heterotopia (HP:0002282)2.44475622
23Tubulointerstitial nephritis (HP:0001970)2.41468315
24Abnormality of chromosome stability (HP:0003220)2.40910402
25Hypoplastic ischia (HP:0003175)2.40228583
26Cystic hygroma (HP:0000476)2.37819437
27Absent frontal sinuses (HP:0002688)2.37320109
28Hyperventilation (HP:0002883)2.33754523
29Truncal obesity (HP:0001956)2.32743510
30Deep philtrum (HP:0002002)2.31965799
31Deviation of the thumb (HP:0009603)2.26293476
32Abnormality of the 4th metacarpal (HP:0010012)2.23544840
33Spinal cord lesions (HP:0100561)2.23338874
34Syringomyelia (HP:0003396)2.23338874
35Proximal placement of thumb (HP:0009623)2.20871997
36Facial hemangioma (HP:0000329)2.20101327
37Neonatal hypoglycemia (HP:0001998)2.19443146
38Widely spaced teeth (HP:0000687)2.18866299
39Fair hair (HP:0002286)2.18796413
40Overgrowth (HP:0001548)2.17754084
41Tapered finger (HP:0001182)2.16950096
42Sandal gap (HP:0001852)2.16067878
43Dysmetric saccades (HP:0000641)2.13999156
44Hyperkalemia (HP:0002153)2.13146934
45Curly hair (HP:0002212)2.10016024
46Hematochezia (HP:0002573)2.09531550
47Trigonocephaly (HP:0000243)2.07996851
48Nephroblastoma (Wilms tumor) (HP:0002667)2.07844526
49Protruding tongue (HP:0010808)2.06994413
50Anal stenosis (HP:0002025)2.06412154
51Lip pit (HP:0100267)2.05265552
52Low anterior hairline (HP:0000294)2.04562987
53Gaze-evoked nystagmus (HP:0000640)2.03731761
54Rhabdomyosarcoma (HP:0002859)2.03660232
55Abnormality of the nasal septum (HP:0000419)2.03229820
56Abnormality of incisor morphology (HP:0011063)2.02863689
57Hypoplastic iliac wings (HP:0002866)2.02724724
58Hyperacusis (HP:0010780)2.01535609
59Embryonal renal neoplasm (HP:0011794)2.00879473
60Dislocated radial head (HP:0003083)2.00000004
61Broad thumb (HP:0011304)1.98959353
62Medulloblastoma (HP:0002885)1.98050038
63Obsessive-compulsive behavior (HP:0000722)1.97304203
64Cutis marmorata (HP:0000965)1.96643261
65Limited elbow extension (HP:0001377)1.95762231
66Impulsivity (HP:0100710)1.94558371
67Large earlobe (HP:0009748)1.94108541
68Chronic hepatic failure (HP:0100626)1.92212649
69Supernumerary ribs (HP:0005815)1.91512364
70Cerebral aneurysm (HP:0004944)1.91092127
71Abnormality of the labia minora (HP:0012880)1.91016170
72Transitional cell carcinoma of the bladder (HP:0006740)1.90218115
73Myelodysplasia (HP:0002863)1.88671972
74Astrocytoma (HP:0009592)1.88251456
75Abnormality of the astrocytes (HP:0100707)1.88251456
76Abnormality of the radial head (HP:0003995)1.87982362
77Ependymoma (HP:0002888)1.87657695
78High pitched voice (HP:0001620)1.87512533
79Neoplasm of the oral cavity (HP:0100649)1.86665365
80Thyroiditis (HP:0100646)1.85471131
81Hypoplasia of the maxilla (HP:0000327)1.83486888
82Subacute progressive viral hepatitis (HP:0006572)1.82906351
83Recurrent viral infections (HP:0004429)1.82633807
84Neoplasm of striated muscle (HP:0009728)1.82545242
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.82198262
86Malignant gastrointestinal tract tumors (HP:0006749)1.80797415
87Gastrointestinal carcinoma (HP:0002672)1.80797415
88Acute lymphatic leukemia (HP:0006721)1.80407737
89Neoplasm of the adrenal cortex (HP:0100641)1.79141195
90Broad palm (HP:0001169)1.79030599
91Glioma (HP:0009733)1.78725725
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78457981
93Shallow orbits (HP:0000586)1.78419199
94Biliary tract neoplasm (HP:0100574)1.78124693
95Prostate neoplasm (HP:0100787)1.76925814
96Synophrys (HP:0000664)1.76243358
97Viral hepatitis (HP:0006562)1.75815314
98Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75188719
99Panhypogammaglobulinemia (HP:0003139)1.73618635
100Abnormality of the carotid arteries (HP:0005344)1.73598653
101T lymphocytopenia (HP:0005403)1.73116715
102Birth length less than 3rd percentile (HP:0003561)1.71591350
103Neoplasm of the tracheobronchial system (HP:0100552)1.71445994
104Hypoplastic labia majora (HP:0000059)1.71063111
105Hip dysplasia (HP:0001385)1.71019342
106Submucous cleft hard palate (HP:0000176)1.70462250
107Aortic aneurysm (HP:0004942)1.69799882
108Cubitus valgus (HP:0002967)1.69397782
109Meckel diverticulum (HP:0002245)1.69229554
110Drooling (HP:0002307)1.69224894
111Leiomyosarcoma (HP:0100243)1.69076887
112Uterine leiomyosarcoma (HP:0002891)1.69076887
113Subaortic stenosis (HP:0001682)1.67887871
114Abnormality of the left ventricular outflow tract (HP:0011103)1.67887871
115Cafe-au-lait spot (HP:0000957)1.67823959
116Broad phalanges of the hand (HP:0009768)1.67552212
117Progressive cerebellar ataxia (HP:0002073)1.67484229
118Spondylolisthesis (HP:0003302)1.67403320
119Aplasia/Hypoplasia of the sternum (HP:0006714)1.67179809
120Cupped ear (HP:0000378)1.66391132
121Bladder carcinoma (HP:0002862)1.66216622
122Bladder neoplasm (HP:0009725)1.66216622
123Vertebral arch anomaly (HP:0008438)1.65811127
124Aqueductal stenosis (HP:0002410)1.65580258
125Oligodactyly (hands) (HP:0001180)1.64988079
126Enlarged penis (HP:0000040)1.64882171
127Diastasis recti (HP:0001540)1.64727458
128Generalized hypopigmentation of hair (HP:0011358)1.64279801
129Excessive salivation (HP:0003781)1.64016897
130Patellar aplasia (HP:0006443)1.63998446
131Tented upper lip vermilion (HP:0010804)1.63042749
132Supernumerary bones of the axial skeleton (HP:0009144)1.62893156
133Abnormality of chromosome segregation (HP:0002916)1.62758109
134Germ cell neoplasia (HP:0100728)1.62671944
1352-3 toe syndactyly (HP:0004691)1.62631956
136Thick eyebrow (HP:0000574)1.62370656
137Papilledema (HP:0001085)1.62335696
138Highly arched eyebrow (HP:0002553)1.62241057
139Hypopigmentation of the fundus (HP:0007894)1.61936029
140Renovascular hypertension (HP:0100817)1.61795481
141Cellulitis (HP:0100658)1.61191585
142Long clavicles (HP:0000890)1.60912024
143Abnormality of the ileum (HP:0001549)1.60370783
144Wide intermamillary distance (HP:0006610)1.60248886
145Abnormality of T cell number (HP:0011839)1.59637012
146Overlapping toe (HP:0001845)1.59473817
147Selective tooth agenesis (HP:0001592)1.58271632
148Agammaglobulinemia (HP:0004432)1.57594619
149Cortical dysplasia (HP:0002539)1.56020006
150Clubbing of toes (HP:0100760)1.54711624
151Basal cell carcinoma (HP:0002671)1.54608241
152Skin tags (HP:0010609)1.53476509
153Midline defect of the nose (HP:0004122)1.53415473
154Broad finger (HP:0001500)1.53295565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.75606214
2LATS13.52667759
3CDC73.14194090
4AKT32.58093852
5CAMK1D2.45463480
6BRD42.36294889
7NEK22.33519995
8FGFR22.11528044
9STK32.09702185
10PLK42.08785741
11CAMK1G1.93870990
12FGFR31.88158615
13EEF2K1.82603056
14STK101.75156938
15NLK1.68629513
16BRSK21.61068098
17ATR1.58909980
18MAP3K101.51777226
19CDK61.42341251
20TNIK1.41069250
21TTK1.39634621
22YES11.38909656
23SRPK11.37185963
24WEE11.35160715
25PLK31.34917932
26CHEK21.34886655
27MAP3K21.33816674
28CDK91.28817598
29AURKB1.27589144
30MAP4K11.27245092
31PDGFRA1.26402505
32CHEK11.26391657
33MARK31.26314676
34MTOR1.25283118
35RIPK11.22601735
36STK41.21735207
37FGFR41.17664316
38ATM1.16991196
39KSR11.16454063
40PDGFRB1.15609018
41MELK1.15566131
42MKNK21.14834543
43TGFBR21.14103349
44NUAK11.13393333
45CHUK1.12872128
46CDK41.12398110
47MKNK11.08769380
48CASK1.05201211
49ACVR1B1.05121776
50SIK21.03680135
51PLK11.02780310
52FRK1.01960359
53SGK31.00790561
54ITK1.00199899
55MARK20.98769876
56ZAK0.94539421
57PTK2B0.93906474
58SGK10.93444269
59SGK4940.92789301
60SGK2230.92789301
61PIM10.92283936
62CDK70.91994181
63DMPK0.91716702
64JAK30.90164205
65RPS6KB20.88758945
66RPS6KA40.88521356
67CDK20.87935882
68TGFBR10.87161703
69IRAK10.86999472
70LATS20.86936273
71ALK0.86339655
72MAP3K140.86252855
73STK38L0.85885700
74PIK3CG0.83720036
75TEC0.83032590
76MAP3K40.81827438
77EIF2AK30.80007269
78PTK60.79624043
79DYRK30.79459117
80PRKAA20.79001095
81FGR0.78521516
82SCYL20.77129329
83CDK10.76150044
84SIK10.74942656
85MAP3K80.73920070
86TYRO30.73759371
87RET0.72493146
88TSSK60.72103437
89RAF10.71325578
90JAK10.68662170
91EIF2AK10.68253505
92TRPM70.67706462
93CCNB10.67271382
94CSF1R0.67067905
95NEK60.66775136
96RIPK40.64931008
97PRPF4B0.63746346
98SGK20.63078251
99KSR20.62376326
100MET0.62161127
101FGFR10.61930705
102FES0.61220128
103PIK3CA0.60560187
104ERBB30.59779311
105MAPK140.59769546
106ERBB20.59730386
107TAOK30.59072695
108PAK30.58947923
109CSNK1D0.57470635
110BLK0.57254700
111PKN20.56985668
112PRKDC0.56241777
113EPHA30.55636103
114MAP3K70.54418150
115ICK0.53432438
116NEK90.52719733
117TAOK10.51958677
118STK110.51484011
119IRAK20.51113967
120HIPK20.50436151
121TYK20.49718349
122HCK0.49656986
123CLK10.49571398
124AKT10.49531695
125SIK30.49429968
126WNK10.49377264
127PNCK0.48917632
128CDK30.48195486
129PLK20.48150745
130BCR0.47901333
131PASK0.47631753
132MAPK10.47599694
133TTN0.46659573
134JAK20.46129791
135STK380.45235347
136GSK3B0.44306288
137MAPK100.43941801
138RPS6KB10.43857520
139BRSK10.43469980
140BTK0.43312176
141CDC42BPA0.42886061
142TIE10.42694514
143TAF10.42362003
144PRKAA10.41470736
145MAPK80.40257560
146AKT20.39576405

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.35552392
2Non-homologous end-joining_Homo sapiens_hsa034502.10400316
3MicroRNAs in cancer_Homo sapiens_hsa052061.85646809
4RNA transport_Homo sapiens_hsa030131.82774996
5mRNA surveillance pathway_Homo sapiens_hsa030151.80665407
6Fanconi anemia pathway_Homo sapiens_hsa034601.74231054
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73815458
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.67223898
9Chronic myeloid leukemia_Homo sapiens_hsa052201.61292283
10B cell receptor signaling pathway_Homo sapiens_hsa046621.57270663
11Small cell lung cancer_Homo sapiens_hsa052221.51263511
12Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50851664
13Primary immunodeficiency_Homo sapiens_hsa053401.50518433
14p53 signaling pathway_Homo sapiens_hsa041151.50494454
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50471294
16Spliceosome_Homo sapiens_hsa030401.45014680
17Base excision repair_Homo sapiens_hsa034101.43491250
18Adherens junction_Homo sapiens_hsa045201.42594421
19Viral carcinogenesis_Homo sapiens_hsa052031.39337041
20Herpes simplex infection_Homo sapiens_hsa051681.35930514
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34143997
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32049368
23Circadian rhythm_Homo sapiens_hsa047101.31105885
24Homologous recombination_Homo sapiens_hsa034401.30984659
25Colorectal cancer_Homo sapiens_hsa052101.30350872
26mTOR signaling pathway_Homo sapiens_hsa041501.28645867
27* Lysine degradation_Homo sapiens_hsa003101.28623054
28RNA degradation_Homo sapiens_hsa030181.27780411
29HTLV-I infection_Homo sapiens_hsa051661.26734468
30Pancreatic cancer_Homo sapiens_hsa052121.26125110
31Systemic lupus erythematosus_Homo sapiens_hsa053221.23418195
32Prostate cancer_Homo sapiens_hsa052151.22388129
33Mismatch repair_Homo sapiens_hsa034301.21542920
34Antigen processing and presentation_Homo sapiens_hsa046121.17976707
35DNA replication_Homo sapiens_hsa030301.17747859
36Non-small cell lung cancer_Homo sapiens_hsa052231.16525638
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16487595
38Endometrial cancer_Homo sapiens_hsa052131.12288276
39Hepatitis B_Homo sapiens_hsa051611.11468615
40FoxO signaling pathway_Homo sapiens_hsa040681.11110129
41Osteoclast differentiation_Homo sapiens_hsa043801.10630754
42Notch signaling pathway_Homo sapiens_hsa043301.10009847
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09765786
44Viral myocarditis_Homo sapiens_hsa054161.09612727
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07027474
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06976482
47Epstein-Barr virus infection_Homo sapiens_hsa051691.06516008
48T cell receptor signaling pathway_Homo sapiens_hsa046601.05803584
49Basal transcription factors_Homo sapiens_hsa030221.04689836
50Dorso-ventral axis formation_Homo sapiens_hsa043201.03922916
51Measles_Homo sapiens_hsa051621.03594290
52TGF-beta signaling pathway_Homo sapiens_hsa043501.01036093
53Toxoplasmosis_Homo sapiens_hsa051450.98130101
54Proteoglycans in cancer_Homo sapiens_hsa052050.96020115
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.95817559
56Acute myeloid leukemia_Homo sapiens_hsa052210.95433113
57Oocyte meiosis_Homo sapiens_hsa041140.94885778
58Influenza A_Homo sapiens_hsa051640.93273160
59Long-term potentiation_Homo sapiens_hsa047200.92864977
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88721848
61Pathways in cancer_Homo sapiens_hsa052000.86439236
62TNF signaling pathway_Homo sapiens_hsa046680.85680073
63Insulin resistance_Homo sapiens_hsa049310.85219272
64VEGF signaling pathway_Homo sapiens_hsa043700.85039359
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84416643
66Apoptosis_Homo sapiens_hsa042100.84388400
67Glioma_Homo sapiens_hsa052140.84314911
68Basal cell carcinoma_Homo sapiens_hsa052170.82913093
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.82638568
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82359956
71Hematopoietic cell lineage_Homo sapiens_hsa046400.81831837
72Hippo signaling pathway_Homo sapiens_hsa043900.81351585
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81190227
74One carbon pool by folate_Homo sapiens_hsa006700.80499659
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.80353783
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.79774104
77Focal adhesion_Homo sapiens_hsa045100.79470644
78Prolactin signaling pathway_Homo sapiens_hsa049170.78320065
79Renal cell carcinoma_Homo sapiens_hsa052110.77677392
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.77428986
81Nucleotide excision repair_Homo sapiens_hsa034200.77009484
82Platelet activation_Homo sapiens_hsa046110.76569570
83Leishmaniasis_Homo sapiens_hsa051400.76466567
84Fatty acid biosynthesis_Homo sapiens_hsa000610.75842131
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75166504
86Wnt signaling pathway_Homo sapiens_hsa043100.75113074
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74576999
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74093694
89ABC transporters_Homo sapiens_hsa020100.72219780
90Type II diabetes mellitus_Homo sapiens_hsa049300.71419220
91GnRH signaling pathway_Homo sapiens_hsa049120.70950039
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.70318472
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69125054
94Long-term depression_Homo sapiens_hsa047300.68914466
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68796532
96Thyroid cancer_Homo sapiens_hsa052160.68792134
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68420287
98Inositol phosphate metabolism_Homo sapiens_hsa005620.67693457
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67453275
100Chemokine signaling pathway_Homo sapiens_hsa040620.67387900
101ErbB signaling pathway_Homo sapiens_hsa040120.67288700
102Hepatitis C_Homo sapiens_hsa051600.66477711
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66388529
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65598542
105Alcoholism_Homo sapiens_hsa050340.65311935
106Choline metabolism in cancer_Homo sapiens_hsa052310.63410423
107MAPK signaling pathway_Homo sapiens_hsa040100.59545947
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58900602
109ECM-receptor interaction_Homo sapiens_hsa045120.58472704
110AMPK signaling pathway_Homo sapiens_hsa041520.57255747
111Shigellosis_Homo sapiens_hsa051310.57204943
112cAMP signaling pathway_Homo sapiens_hsa040240.55869186
113Pancreatic secretion_Homo sapiens_hsa049720.55789488
114Estrogen signaling pathway_Homo sapiens_hsa049150.54854212
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54050349
116Cholinergic synapse_Homo sapiens_hsa047250.53936605
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53606136
118Rap1 signaling pathway_Homo sapiens_hsa040150.53271676
119Glucagon signaling pathway_Homo sapiens_hsa049220.51890904
120Insulin signaling pathway_Homo sapiens_hsa049100.50921761
121Ras signaling pathway_Homo sapiens_hsa040140.50302712
122Regulation of autophagy_Homo sapiens_hsa041400.49381276
123Axon guidance_Homo sapiens_hsa043600.48700317
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47785880
125Melanoma_Homo sapiens_hsa052180.45851501

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