SETD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.56591826
2muscle filament sliding (GO:0030049)6.56591826
3sarcoplasmic reticulum calcium ion transport (GO:0070296)6.15386220
4actin-mediated cell contraction (GO:0070252)5.59939590
5skeletal muscle contraction (GO:0003009)5.13093813
6actin filament-based movement (GO:0030048)4.51403988
7NADH metabolic process (GO:0006734)4.51108501
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.46989708
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.43479419
10skeletal muscle adaptation (GO:0043501)4.31094096
11sarcomere organization (GO:0045214)4.22469598
12glycogen catabolic process (GO:0005980)4.21519367
13striated muscle contraction (GO:0006941)4.15945868
14glucan catabolic process (GO:0009251)4.00288564
15cellular polysaccharide catabolic process (GO:0044247)3.88370441
16cardiac muscle contraction (GO:0060048)3.71393786
17regulation of relaxation of muscle (GO:1901077)3.69320927
18polysaccharide catabolic process (GO:0000272)3.60881922
19myofibril assembly (GO:0030239)3.60838589
20synaptic vesicle maturation (GO:0016188)3.59043864
21response to muscle activity (GO:0014850)3.48253929
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.48123183
23lysine catabolic process (GO:0006554)3.46078590
24lysine metabolic process (GO:0006553)3.46078590
25pinocytosis (GO:0006907)3.34239988
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33345807
27regulation of skeletal muscle contraction (GO:0014819)3.32978423
28actomyosin structure organization (GO:0031032)3.30215868
29striated muscle hypertrophy (GO:0014897)3.28531276
30macroautophagy (GO:0016236)3.28024190
31activation of protein kinase A activity (GO:0034199)3.26119395
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24675075
33fructose metabolic process (GO:0006000)3.23819710
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21737774
35Golgi transport vesicle coating (GO:0048200)3.20644396
36COPI coating of Golgi vesicle (GO:0048205)3.20644396
37nuclear pore complex assembly (GO:0051292)3.20557890
38sodium ion export (GO:0071436)3.16379092
39glucan biosynthetic process (GO:0009250)3.12976049
40glycogen biosynthetic process (GO:0005978)3.12976049
41cardiac muscle hypertrophy (GO:0003300)3.08333499
42cellular response to thyroid hormone stimulus (GO:0097067)3.07912375
43muscle contraction (GO:0006936)3.07891442
44striated muscle adaptation (GO:0014888)3.07858247
45regulation of actin filament-based movement (GO:1903115)3.03478668
46regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.01391304
47pentose-phosphate shunt (GO:0006098)3.00651012
48alpha-linolenic acid metabolic process (GO:0036109)3.00030566
49gluconeogenesis (GO:0006094)2.99243136
50glycosphingolipid catabolic process (GO:0046479)2.99218383
51cellular potassium ion homeostasis (GO:0030007)2.98826775
52locomotory exploration behavior (GO:0035641)2.98355597
53muscle hypertrophy (GO:0014896)2.95830310
54response to inactivity (GO:0014854)2.94913721
55positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.93480486
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91335424
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.90815033
58L-phenylalanine catabolic process (GO:0006559)2.90815033
59aspartate family amino acid catabolic process (GO:0009068)2.89771266
60syncytium formation by plasma membrane fusion (GO:0000768)2.89650786
61positive regulation of receptor recycling (GO:0001921)2.88982496
62myoblast fusion (GO:0007520)2.87973383
63creatine metabolic process (GO:0006600)2.87906006
64L-phenylalanine metabolic process (GO:0006558)2.85842227
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.85842227
66dicarboxylic acid biosynthetic process (GO:0043650)2.85562265
67muscle adaptation (GO:0043500)2.85238008
68NADPH regeneration (GO:0006740)2.84970496
69COPII vesicle coating (GO:0048208)2.84927584
702-oxoglutarate metabolic process (GO:0006103)2.84886226
71protein localization to endosome (GO:0036010)2.84107964
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.83660427
73cardiac myofibril assembly (GO:0055003)2.82377397
74muscle atrophy (GO:0014889)2.81573199
75positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.81481251
76retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79371845
77regulation of early endosome to late endosome transport (GO:2000641)2.77425229
78hexose biosynthetic process (GO:0019319)2.77219042
79muscle system process (GO:0003012)2.77174552
80glycogen metabolic process (GO:0005977)2.75891780
81negative regulation of protein localization to plasma membrane (GO:1903077)2.75883455
82cell communication by electrical coupling (GO:0010644)2.74820125
83striated muscle atrophy (GO:0014891)2.74160557
84layer formation in cerebral cortex (GO:0021819)2.74050578
85glycolipid catabolic process (GO:0019377)2.73665014
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73023860
87glutamate secretion (GO:0014047)2.71768915
88glucan metabolic process (GO:0044042)2.71595819
89cellular glucan metabolic process (GO:0006073)2.71595819
90AMP metabolic process (GO:0046033)2.71590156
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69516572
92glutamate metabolic process (GO:0006536)2.68904628
93regulation of synaptic vesicle exocytosis (GO:2000300)2.68643657
94regulation of receptor recycling (GO:0001919)2.68616453
95histone H3-K36 demethylation (GO:0070544)2.68355580
96succinate metabolic process (GO:0006105)2.67592010
97tricarboxylic acid metabolic process (GO:0072350)2.64281713
98synaptic vesicle exocytosis (GO:0016079)2.64260322
99focal adhesion assembly (GO:0048041)2.63988525
100cell-substrate adherens junction assembly (GO:0007045)2.63988525
101heart contraction (GO:0060047)2.62566734
102heart process (GO:0003015)2.62566734
103protein targeting to Golgi (GO:0000042)2.62440039
104monosaccharide biosynthetic process (GO:0046364)2.62388926
105neutrophil activation involved in immune response (GO:0002283)2.62154918
106pore complex assembly (GO:0046931)2.61547897
107epithelial cell-cell adhesion (GO:0090136)2.61132565
108regulation of cholesterol homeostasis (GO:2000188)2.59874769
109regulation of ARF protein signal transduction (GO:0032012)2.59714188
110potassium ion import (GO:0010107)2.58544950
111fatty acid transmembrane transport (GO:1902001)2.58350626
112response to thyroid hormone (GO:0097066)2.58234186
113plasma membrane repair (GO:0001778)2.57908886
114neurotransmitter secretion (GO:0007269)2.57407965
115cellular protein complex localization (GO:0034629)2.57085216
116nucleotide salvage (GO:0043173)2.56439460
117nuclear pore organization (GO:0006999)2.56359752
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.55945723
119regulation of cell communication by electrical coupling (GO:0010649)2.54879009
120fatty acid homeostasis (GO:0055089)2.53753505
121establishment of protein localization to Golgi (GO:0072600)2.51154892
122carnitine shuttle (GO:0006853)2.50014620
123proline transport (GO:0015824)2.49717426
124regulation of fatty acid beta-oxidation (GO:0031998)2.49458439
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.49429501
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.49371120
127cysteine metabolic process (GO:0006534)2.49175670
128regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.48809102
129cell communication involved in cardiac conduction (GO:0086065)2.47275682
130barbed-end actin filament capping (GO:0051016)2.47263906
131dicarboxylic acid catabolic process (GO:0043649)2.47229897
132cerebellar Purkinje cell layer development (GO:0021680)2.46607459
133regulation of clathrin-mediated endocytosis (GO:2000369)2.45705202
1344-hydroxyproline metabolic process (GO:0019471)2.45704014
135vesicle transport along microtubule (GO:0047496)2.44017597
136activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.43568274
137IMP metabolic process (GO:0046040)2.43110085
138adherens junction assembly (GO:0034333)2.42854331
139negative regulation of necroptotic process (GO:0060546)2.42633945
140skeletal muscle fiber development (GO:0048741)2.42334224
141histone H3-K9 demethylation (GO:0033169)2.41956783
142positive regulation of glycolytic process (GO:0045821)2.41814510
143folic acid-containing compound biosynthetic process (GO:0009396)2.41616017
144oxaloacetate metabolic process (GO:0006107)2.39700302
145cellular sodium ion homeostasis (GO:0006883)2.39533020
146oligosaccharide catabolic process (GO:0009313)2.39376699
147glucose catabolic process (GO:0006007)2.38769088
148alanine transport (GO:0032328)2.38686807
149membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.37456426
150glycine transport (GO:0015816)2.35693408
151membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35504270
152acylglycerol catabolic process (GO:0046464)2.33340146
153neutral lipid catabolic process (GO:0046461)2.33340146
154regulation of synapse structural plasticity (GO:0051823)2.32431453
155positive regulation of fatty acid beta-oxidation (GO:0032000)2.31293005
156regulation of synaptic vesicle transport (GO:1902803)2.31201334
157drug transmembrane transport (GO:0006855)2.31177333
158cellular modified amino acid catabolic process (GO:0042219)2.30405367
159low-density lipoprotein particle clearance (GO:0034383)2.30021623
160cellular ketone body metabolic process (GO:0046950)2.29786852
161negative regulation of potassium ion transmembrane transport (GO:1901380)2.28378522
162negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.28341640
163short-chain fatty acid metabolic process (GO:0046459)2.27614835
164valine metabolic process (GO:0006573)2.27212312
165retrograde transport, vesicle recycling within Golgi (GO:0000301)2.26641648
166fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.24768072
167positive regulation of nuclease activity (GO:0032075)2.24546280
168sulfur amino acid catabolic process (GO:0000098)2.23758973
169triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.23514488
170drug catabolic process (GO:0042737)2.23383541
171neuromuscular process controlling posture (GO:0050884)2.22505528
172nerve growth factor signaling pathway (GO:0038180)2.22014966
173positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.20874971
174amino-acid betaine transport (GO:0015838)2.19817648
175carnitine transport (GO:0015879)2.19817648
176membrane repolarization (GO:0086009)2.19152844
177negative regulation of cell size (GO:0045792)2.19059418
178neuromuscular process controlling balance (GO:0050885)2.18853402
179potassium ion homeostasis (GO:0055075)2.18443417
180acetyl-CoA metabolic process (GO:0006084)2.18225001
181regulation of fatty acid oxidation (GO:0046320)2.15126620
182tricarboxylic acid cycle (GO:0006099)2.12514836
183phosphate ion transport (GO:0006817)2.11711314
184endoplasmic reticulum organization (GO:0007029)2.11053934
185triglyceride catabolic process (GO:0019433)2.10302166
186aromatic amino acid family catabolic process (GO:0009074)2.10116623
187carnitine transmembrane transport (GO:1902603)2.09964709
188neuronal action potential propagation (GO:0019227)2.09837837
189membrane repolarization during action potential (GO:0086011)2.09452517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.66895791
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79126730
3E2F7_22180533_ChIP-Seq_HELA_Human2.73508939
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.72997515
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.48078430
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45079148
7AR_21909140_ChIP-Seq_LNCAP_Human2.41336072
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.37731937
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32082825
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.27163109
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23725754
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12150390
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.02609314
14EZH2_22144423_ChIP-Seq_EOC_Human2.01552972
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01363909
16MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94910738
17CLOCK_20551151_ChIP-Seq_293T_Human1.92020790
18DROSHA_22980978_ChIP-Seq_HELA_Human1.91725742
19SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.89138855
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88890009
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85522267
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79711939
23KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77318463
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75606172
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72597303
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72583399
27ZNF263_19887448_ChIP-Seq_K562_Human1.71774936
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71345046
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.61067242
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60503615
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60267688
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59972867
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59247484
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58486495
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58396423
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57354654
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56809233
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56179846
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.55538199
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53348920
41GATA1_22025678_ChIP-Seq_K562_Human1.52964487
42NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.50196714
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47543827
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.47297560
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.44742862
46* KDM2B_26808549_Chip-Seq_K562_Human1.44617148
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44333471
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44000458
49SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44000458
50TFEB_21752829_ChIP-Seq_HELA_Human1.43641578
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43243004
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41867248
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41202353
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40781956
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.38681990
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37898182
57GATA4_21415370_ChIP-Seq_HL-1_Mouse1.36654901
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.35402476
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34443928
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33817811
61REST_21632747_ChIP-Seq_MESCs_Mouse1.33354248
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31316574
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29897063
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29568421
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.28722519
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28186981
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27825782
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27596818
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26093571
70* GATA3_24758297_ChIP-Seq_MCF-7_Human1.25782263
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25752684
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25752684
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.25740531
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25152242
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.23763046
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.22629006
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22386478
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21337695
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21128766
80LXR_22292898_ChIP-Seq_THP-1_Human1.19888228
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18712085
82PU_27001747_Chip-Seq_BMDM_Mouse1.17990550
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17180464
84KDM2B_26808549_Chip-Seq_DND41_Human1.16977899
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16328161
86TCF7_22412390_ChIP-Seq_EML_Mouse1.15820867
87* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15641250
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15566688
89* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15306166
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.14728417
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14661062
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13266272
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13057676
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12105752
95ZNF274_21170338_ChIP-Seq_K562_Hela1.11495735
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11414953
97SOX2_20726797_ChIP-Seq_SW620_Human1.11369694
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.10973775
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10846693
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.09740743
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09689362
102CREB1_26743006_Chip-Seq_LNCaP_Human1.09562109
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08839074
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.08595059
105TBX20_22328084_ChIP-Seq_HEART_Mouse1.08595059
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08429537
107MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08105060
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.08005671
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07640514
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06305957
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06215459
112SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06181473
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05665840
114TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05417874
115GATA6_25053715_ChIP-Seq_YYC3_Human1.05206986
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05199256
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.04411685
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03891105
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03740946
120* GATA1_19941826_ChIP-Seq_K562_Human1.03660424
121GATA1_19941827_ChIP-Seq_MEL_Mouse1.03351807
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.02017749
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01536214
124CHD1_26751641_Chip-Seq_LNCaP_Human1.01503459
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00343422
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99161628
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.98573423
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98053068
129EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98034374
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97095245
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96769331
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95547615
133* AR_19668381_ChIP-Seq_PC3_Human0.95414423
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94676263
135AHR_22903824_ChIP-Seq_MCF-7_Human0.94512639
136KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94084520
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93228015
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93176069
139GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92510042
140RACK7_27058665_Chip-Seq_MCF-7_Human0.92353653
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91001235
142ATF3_27146783_Chip-Seq_COLON_Human0.90368302
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90054155
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89950244
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89782167
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.88285579
147RXR_22108803_ChIP-Seq_LS180_Human0.88116333
148BCAT_22108803_ChIP-Seq_LS180_Human0.88021604
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87759685
150KLF4_19829295_ChIP-Seq_ESCs_Human0.87314577
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.86716376
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.85966744
153RNF2_27304074_Chip-Seq_ESCs_Mouse0.85261921
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83421762
155* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83376526
156* TET1_21490601_ChIP-Seq_MESCs_Mouse0.82614339
157CTCF_27219007_Chip-Seq_Bcells_Human0.82532403
158ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82197017
159FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81884172
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.81688555
161ARNT_22903824_ChIP-Seq_MCF-7_Human0.81080017
162* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80486305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.58826201
2MP0005451_abnormal_body_composition3.55358498
3MP0002139_abnormal_hepatobiliary_system3.40126576
4MP0005360_urolithiasis3.16089760
5MP0002909_abnormal_adrenal_gland2.92945580
6MP0004130_abnormal_muscle_cell2.54490143
7MP0005365_abnormal_bile_salt2.51919295
8MP0005085_abnormal_gallbladder_physiolo2.47697622
9MP0009780_abnormal_chondrocyte_physiolo2.43851459
10MP0010352_gastrointestinal_tract_polyps2.43704414
11MP0010234_abnormal_vibrissa_follicle2.36103727
12MP0002837_dystrophic_cardiac_calcinosis2.33772687
13MP0002332_abnormal_exercise_endurance2.25378801
14MP0003252_abnormal_bile_duct2.17907534
15MP0000759_abnormal_skeletal_muscle2.16076547
16MP0003195_calcinosis2.13628852
17MP0003705_abnormal_hypodermis_morpholog2.13011134
18MP0003283_abnormal_digestive_organ2.12334595
19MP0004043_abnormal_pH_regulation2.11751596
20MP0000013_abnormal_adipose_tissue2.04555785
21MP0004270_analgesia2.04455655
22MP0003635_abnormal_synaptic_transmissio1.97412557
23MP0003300_gastrointestinal_ulcer1.96159209
24MP0003329_amyloid_beta_deposits1.95911890
25MP0002822_catalepsy1.92961636
26MP0010329_abnormal_lipoprotein_level1.85998943
27MP0008961_abnormal_basal_metabolism1.85743508
28MP0008875_abnormal_xenobiotic_pharmacok1.82554467
29MP0003566_abnormal_cell_adhesion1.81930305
30MP0005083_abnormal_biliary_tract1.81361647
31MP0002972_abnormal_cardiac_muscle1.79585064
32MP0002106_abnormal_muscle_physiology1.78684876
33MP0000751_myopathy1.73038787
34MP0010630_abnormal_cardiac_muscle1.66767568
35MP0004185_abnormal_adipocyte_glucose1.60996630
36MP0001661_extended_life_span1.60307608
37MP0010678_abnormal_skin_adnexa1.55707635
38MP0000747_muscle_weakness1.55002120
39MP0005332_abnormal_amino_acid1.50301544
40MP0001666_abnormal_nutrient_absorption1.49940279
41MP0004858_abnormal_nervous_system1.49883963
42MP0000003_abnormal_adipose_tissue1.48469398
43MP0004510_myositis1.48408366
44MP0004036_abnormal_muscle_relaxation1.47817659
45MP0005666_abnormal_adipose_tissue1.47346494
46MP0000733_abnormal_muscle_development1.46211694
47MP0000604_amyloidosis1.44174781
48MP0002118_abnormal_lipid_homeostasis1.44020750
49MP0003453_abnormal_keratinocyte_physiol1.43779619
50MP0002877_abnormal_melanocyte_morpholog1.42644736
51MP0005058_abnormal_lysosome_morphology1.42509728
52MP0003950_abnormal_plasma_membrane1.40838497
53MP0005369_muscle_phenotype1.40564807
54MP0002063_abnormal_learning/memory/cond1.40466221
55MP0005375_adipose_tissue_phenotype1.40152087
56MP0006138_congestive_heart_failure1.40080614
57MP0002064_seizures1.39563581
58MP0005535_abnormal_body_temperature1.38522631
59MP0005165_increased_susceptibility_to1.38103035
60MP0000750_abnormal_muscle_regeneration1.36814140
61MP0003828_pulmonary_edema1.36257095
62MP0002078_abnormal_glucose_homeostasis1.35414195
63MP0003941_abnormal_skin_development1.34105531
64MP0009745_abnormal_behavioral_response1.32707062
65MP0004145_abnormal_muscle_electrophysio1.32594571
66MP0003690_abnormal_glial_cell1.30804374
67MP0004084_abnormal_cardiac_muscle1.30336399
68MP0004484_altered_response_of1.28647001
69MP0001765_abnormal_ion_homeostasis1.28197361
70MP0003221_abnormal_cardiomyocyte_apopto1.27288150
71MP0005167_abnormal_blood-brain_barrier1.27212891
72MP0003045_fibrosis1.26985190
73MP0003633_abnormal_nervous_system1.25885993
74MP0002796_impaired_skin_barrier1.24984493
75MP0009046_muscle_twitch1.22998763
76MP0009840_abnormal_foam_cell1.22344510
77MP0003656_abnormal_erythrocyte_physiolo1.18921591
78MP0001501_abnormal_sleep_pattern1.18329581
79MP0002269_muscular_atrophy1.16073016
80MP0000343_altered_response_to1.14857130
81MP0005409_darkened_coat_color1.14463518
82MP0002166_altered_tumor_susceptibility1.13540457
83MP0003172_abnormal_lysosome_physiology1.12892635
84MP0003646_muscle_fatigue1.12408604
85MP0004264_abnormal_extraembryonic_tissu1.12328626
86MP0009672_abnormal_birth_weight1.11052450
87MP0004215_abnormal_myocardial_fiber1.10558306
88MP0005584_abnormal_enzyme/coenzyme_acti1.09674441
89MP0009643_abnormal_urine_homeostasis1.08755979
90MP0004233_abnormal_muscle_weight1.08347282
91MP0004087_abnormal_muscle_fiber1.08153856
92MP0005623_abnormal_meninges_morphology1.06559702
93MP0008260_abnormal_autophagy1.06148591
94MP0002090_abnormal_vision1.05604839
95MP0003191_abnormal_cellular_cholesterol1.05535247
96MP0002733_abnormal_thermal_nociception1.04678170
97MP0002272_abnormal_nervous_system1.03788506
98MP0005377_hearing/vestibular/ear_phenot1.02544161
99MP0003878_abnormal_ear_physiology1.02544161
100MP0001944_abnormal_pancreas_morphology1.02177974
101MP0004885_abnormal_endolymph1.01800523
102MP0003075_altered_response_to1.01663542
103MP0001756_abnormal_urination1.00976896
104MP0002971_abnormal_brown_adipose1.00490280
105MP0000383_abnormal_hair_follicle0.99259596
106MP0005464_abnormal_platelet_physiology0.99048934
107MP0002734_abnormal_mechanical_nocicepti0.98949631
108MP0002138_abnormal_hepatobiliary_system0.97541442
109MP0000609_abnormal_liver_physiology0.96997773
110MP0003806_abnormal_nucleotide_metabolis0.96929294
111MP0001544_abnormal_cardiovascular_syste0.96901446
112MP0005385_cardiovascular_system_phenoty0.96901446
113MP0004811_abnormal_neuron_physiology0.94766933
114MP0002998_abnormal_bone_remodeling0.94657083
115MP0006036_abnormal_mitochondrial_physio0.94487997
116MP0001440_abnormal_grooming_behavior0.93303507
117MP0002572_abnormal_emotion/affect_behav0.93139806
118MP0002693_abnormal_pancreas_physiology0.92559234
119MP0001968_abnormal_touch/_nociception0.92397759
120MP0008569_lethality_at_weaning0.91614254
121MP0003868_abnormal_feces_composition0.91143852
122MP0005266_abnormal_metabolism0.90467618
123MP0005330_cardiomyopathy0.90180712
124MP0005620_abnormal_muscle_contractility0.89855765
125MP0002127_abnormal_cardiovascular_syste0.86318957
126MP0005670_abnormal_white_adipose0.86273495
127MP0005319_abnormal_enzyme/_coenzyme0.85834146
128MP0003631_nervous_system_phenotype0.85657994
129MP0003091_abnormal_cell_migration0.82774214
130MP0005187_abnormal_penis_morphology0.82675135
131MP0005166_decreased_susceptibility_to0.82464961
132MP0002896_abnormal_bone_mineralization0.81708338
133MP0000749_muscle_degeneration0.81051202
134MP0008874_decreased_physiological_sensi0.80452953
135MP0003183_abnormal_peptide_metabolism0.79765870
136MP0005257_abnormal_intraocular_pressure0.79553011
137MP0000569_abnormal_digit_pigmentation0.79437552
138MP0004924_abnormal_behavior0.78488110
139MP0005386_behavior/neurological_phenoty0.78488110
140MP0001730_embryonic_growth_arrest0.78151200
141MP0003953_abnormal_hormone_level0.78059210
142MP0001970_abnormal_pain_threshold0.77853065
143MP0002006_tumorigenesis0.77209310
144MP0001299_abnormal_eye_distance/0.76836447
145MP0004085_abnormal_heartbeat0.76123931
146MP0000230_abnormal_systemic_arterial0.76074344
147MP0008775_abnormal_heart_ventricle0.75823081
148MP0003879_abnormal_hair_cell0.75736581
149MP0002108_abnormal_muscle_morphology0.73315582
150MP0010307_abnormal_tumor_latency0.73034124
151MP0001727_abnormal_embryo_implantation0.72870971
152MP0004272_abnormal_basement_membrane0.72729502
153MP0001849_ear_inflammation0.71590319
154MP0009115_abnormal_fat_cell0.70238347
155MP0002009_preneoplasia0.66318101
156MP0000266_abnormal_heart_morphology0.64124792
157MP0003448_altered_tumor_morphology0.63881955
158MP0001216_abnormal_epidermal_layer0.62456135
159MP0004808_abnormal_hematopoietic_stem0.61278042
160MP0001853_heart_inflammation0.59279622
161MP0000377_abnormal_hair_follicle0.57051263
162MP0002086_abnormal_extraembryonic_tissu0.55664064

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)7.42702071
2Muscle fiber inclusion bodies (HP:0100299)7.41147981
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.22169616
4Type 1 muscle fiber predominance (HP:0003803)5.26999672
5EMG: myopathic abnormalities (HP:0003458)4.39444441
6Centrally nucleated skeletal muscle fibers (HP:0003687)4.32473496
7Distal lower limb muscle weakness (HP:0009053)3.95025244
8Increased connective tissue (HP:0009025)3.73687097
9Rhabdomyolysis (HP:0003201)3.71533731
10Abnormality of skeletal muscle fiber size (HP:0012084)3.66425307
11Abnormality of the left ventricular outflow tract (HP:0011103)3.60597377
12Subaortic stenosis (HP:0001682)3.60597377
13Muscle hypertrophy of the lower extremities (HP:0008968)3.59150144
14Distal arthrogryposis (HP:0005684)3.58440972
15Muscle fiber splitting (HP:0003555)3.54449443
16Neck muscle weakness (HP:0000467)3.36463652
17Calf muscle hypertrophy (HP:0008981)3.27709514
18Ketoacidosis (HP:0001993)3.23691824
19Visual hallucinations (HP:0002367)3.14204385
20Increased variability in muscle fiber diameter (HP:0003557)3.12039570
21Distal lower limb amyotrophy (HP:0008944)3.11528331
22Ventricular tachycardia (HP:0004756)3.10516703
23Round ear (HP:0100830)3.08350076
24Myopathic facies (HP:0002058)3.05428731
25Myokymia (HP:0002411)3.03905504
26Rimmed vacuoles (HP:0003805)3.02083152
27Abnormality of the calf musculature (HP:0001430)3.01807923
28Ulnar deviation of the wrist (HP:0003049)2.98421326
29Right ventricular cardiomyopathy (HP:0011663)2.94921013
30Gout (HP:0001997)2.94411119
31Ketosis (HP:0001946)2.86763027
32Hypoglycemic coma (HP:0001325)2.83024288
33Xanthomatosis (HP:0000991)2.74624655
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.72736094
35Deep venous thrombosis (HP:0002625)2.71887172
36Exercise-induced myalgia (HP:0003738)2.69321125
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.67923034
38Myoglobinuria (HP:0002913)2.66339617
39Action tremor (HP:0002345)2.66013914
40Hyperinsulinemic hypoglycemia (HP:0000825)2.64491777
41Resting tremor (HP:0002322)2.61003499
42Progressive muscle weakness (HP:0003323)2.59269316
43Mildly elevated creatine phosphokinase (HP:0008180)2.54673017
44Focal motor seizures (HP:0011153)2.54147148
45Muscle stiffness (HP:0003552)2.49262310
46Atrioventricular block (HP:0001678)2.48845729
47Scapular winging (HP:0003691)2.46343511
48Bundle branch block (HP:0011710)2.45430026
49Abnormal atrioventricular conduction (HP:0005150)2.44048648
50Heart block (HP:0012722)2.42934816
51Intrahepatic cholestasis (HP:0001406)2.41492043
52Exercise-induced muscle cramps (HP:0003710)2.39911852
53Axonal loss (HP:0003447)2.38193845
54Abnormality of the lower motor neuron (HP:0002366)2.37536259
55Areflexia of lower limbs (HP:0002522)2.35266712
56Focal seizures (HP:0007359)2.34310871
57Dysmetric saccades (HP:0000641)2.33175404
58Global brain atrophy (HP:0002283)2.32461683
59Dilated cardiomyopathy (HP:0001644)2.32080510
60Difficulty running (HP:0009046)2.29797550
61Lipoatrophy (HP:0100578)2.28906348
62Hyporeflexia of lower limbs (HP:0002600)2.25948615
63Hypoglycemic seizures (HP:0002173)2.25851711
64Cerebral inclusion bodies (HP:0100314)2.25798717
65Abnormality of the Achilles tendon (HP:0005109)2.23935703
66Distal upper limb amyotrophy (HP:0007149)2.18637568
67Upper limb amyotrophy (HP:0009129)2.18637568
68Supranuclear gaze palsy (HP:0000605)2.18554611
69Depression (HP:0000716)2.18021675
70Bulbar palsy (HP:0001283)2.17458730
71Ankle clonus (HP:0011448)2.16998570
72Hyperglycemia (HP:0003074)2.16731732
73Papilledema (HP:0001085)2.16434447
74Progressive external ophthalmoplegia (HP:0000590)2.15762502
75Postural instability (HP:0002172)2.15466111
76Lower limb amyotrophy (HP:0007210)2.15304210
77Generalized muscle weakness (HP:0003324)2.11575663
78Ragged-red muscle fibers (HP:0003200)2.11260274
79EMG: neuropathic changes (HP:0003445)2.11112875
80Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10668725
81Abnormality of purine metabolism (HP:0004352)2.10514284
82Ventricular fibrillation (HP:0001663)2.09479055
83Termporal pattern (HP:0011008)2.08506889
84Insidious onset (HP:0003587)2.08506889
85Skin nodule (HP:0200036)2.08357729
86Hyperlipoproteinemia (HP:0010980)2.07686920
87Achilles tendon contracture (HP:0001771)2.07202469
88Hypoalphalipoproteinemia (HP:0003233)2.07049997
89Complement deficiency (HP:0004431)2.06117973
90Intention tremor (HP:0002080)2.04789630
91Impaired vibration sensation in the lower limbs (HP:0002166)2.04658802
92Reduced subcutaneous adipose tissue (HP:0003758)2.04159499
93Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03635473
94Calcaneovalgus deformity (HP:0001848)2.03435366
95Sudden death (HP:0001699)2.01957952
96Nasal polyposis (HP:0100582)2.01079778
97Generalized tonic-clonic seizures (HP:0002069)2.00446931
98Abnormality of the nasal mucosa (HP:0000433)2.00371106
99Abnormality of glycosphingolipid metabolism (HP:0004343)2.00055383
100Abnormality of glycolipid metabolism (HP:0010969)2.00055383
101Abnormality of liposaccharide metabolism (HP:0010968)2.00055383
102Pheochromocytoma (HP:0002666)1.98290653
103Urinary urgency (HP:0000012)1.97211202
104Upper motor neuron abnormality (HP:0002127)1.97063641
105Spinal rigidity (HP:0003306)1.96857135
106Osteolytic defects of the hand bones (HP:0009699)1.94714680
107Osteolytic defects of the phalanges of the hand (HP:0009771)1.94714680
108Symptomatic seizures (HP:0011145)1.94505626
109Hand muscle atrophy (HP:0009130)1.94173837
110Hyperammonemia (HP:0001987)1.93358588
111Late onset (HP:0003584)1.93304684
112Mucopolysacchariduria (HP:0008155)1.93051594
113Urinary glycosaminoglycan excretion (HP:0003541)1.93051594
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92924059
115Gowers sign (HP:0003391)1.91968747
116Cerebral aneurysm (HP:0004944)1.91145827
117Esophageal varix (HP:0002040)1.90702726
118Sensorimotor neuropathy (HP:0007141)1.90385478
119Impaired social interactions (HP:0000735)1.90223881
120Abnormal social behavior (HP:0012433)1.90223881
121Tetraparesis (HP:0002273)1.88181207
122Retinal atrophy (HP:0001105)1.88099758
123Status epilepticus (HP:0002133)1.87732893
124Macroorchidism (HP:0000053)1.87653820
125Asymmetric septal hypertrophy (HP:0001670)1.87613762
126Back pain (HP:0003418)1.87344426
127Postural tremor (HP:0002174)1.87179219
128Hyperglycinuria (HP:0003108)1.87154658
129Neurofibrillary tangles (HP:0002185)1.86942211
130Increased circulating renin level (HP:0000848)1.85932562
131Rapidly progressive (HP:0003678)1.85679666
132Long toe (HP:0010511)1.84421169
133Abnormality of the fingertips (HP:0001211)1.83580278
134Abnormality of polysaccharide metabolism (HP:0011012)1.83087366
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83087366
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83087366
137Epidermoid cyst (HP:0200040)1.82121515
138Increased purine levels (HP:0004368)1.81426719
139Hyperuricemia (HP:0002149)1.81426719
140Hypercortisolism (HP:0001578)1.81236226
141Absent phalangeal crease (HP:0006109)1.80237579
142Absence seizures (HP:0002121)1.79438390
143Dysostosis multiplex (HP:0000943)1.78482685
144Insulin-resistant diabetes mellitus (HP:0000831)1.77626022
145Abnormality of the common coagulation pathway (HP:0010990)1.77270656
146Abnormal gallbladder morphology (HP:0012437)1.76770340
147Tetraplegia (HP:0002445)1.76526408
148Foot dorsiflexor weakness (HP:0009027)1.76382193
149Clonus (HP:0002169)1.74669129
150Cholelithiasis (HP:0001081)1.74620968
151Frequent falls (HP:0002359)1.74364475
152Microglossia (HP:0000171)1.74028321
153Papillary thyroid carcinoma (HP:0002895)1.73520942
154Dysdiadochokinesis (HP:0002075)1.72564139
155Anxiety (HP:0000739)1.72018733
156Abnormality of the foot musculature (HP:0001436)1.71390911
157Increased CSF protein (HP:0002922)1.70947278
158Increased cerebral lipofuscin (HP:0011813)1.70868859
159Difficulty climbing stairs (HP:0003551)1.70634272
160Neonatal onset (HP:0003623)1.69087101
161Urinary bladder sphincter dysfunction (HP:0002839)1.69005970
162Malignant hyperthermia (HP:0002047)1.68955168
163Hyperkalemia (HP:0002153)1.68908243
164Hamartoma of the eye (HP:0010568)1.68488196
165Multiple enchondromatosis (HP:0005701)1.68081290
166Abnormality of glycine metabolism (HP:0010895)1.67606874
167Abnormality of serine family amino acid metabolism (HP:0010894)1.67606874
168Lymphangioma (HP:0100764)1.67586647
169Insomnia (HP:0100785)1.67447629
170Deformed tarsal bones (HP:0008119)1.66790974
171Myocardial infarction (HP:0001658)1.63101774
172Abnormal finger flexion creases (HP:0006143)1.61979242
173Agnosia (HP:0010524)1.60632962
174Limb-girdle muscle atrophy (HP:0003797)1.56572054
175Ventricular arrhythmia (HP:0004308)1.56426983
176Basal ganglia calcification (HP:0002135)1.55055318
177Abnormality of the salivary glands (HP:0010286)1.50129033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.70760321
2TRIB33.59747091
3PRKD32.63469877
4PKN22.45774182
5KSR22.45291179
6NTRK32.33140499
7MAP3K132.26093603
8MAP3K92.25325572
9MOS2.15195133
10TGFBR22.14638938
11MAP3K22.08993454
12RIPK12.05508065
13EPHA41.99427452
14NTRK11.88872205
15DAPK21.86363565
16CAMKK11.83832244
17MAP2K31.74719472
18WNK41.73960520
19PDK41.71705037
20PDK31.71705037
21PAK61.70434637
22INSRR1.69383804
23LIMK11.68487623
24NEK91.67395274
25MAP3K41.65807754
26LMTK21.65689480
27NEK11.63672202
28PDGFRA1.63593522
29RET1.62998916
30SCYL21.61041115
31MAP2K41.54264632
32IRAK31.52724681
33TRPM71.51035017
34TTN1.48087951
35MAP3K121.41484913
36FRK1.41156302
37PIK3CG1.40642329
38MINK11.39059036
39CAMKK21.38033308
40EIF2AK11.37139926
41PTK61.35970845
42FGFR41.35965425
43ARAF1.34889075
44PBK1.33177610
45TYRO31.33159955
46PRKCH1.29580063
47CAMK1G1.29128537
48SIK11.28207033
49STK381.27691390
50PRPF4B1.27593829
51BCKDK1.27246689
52EIF2AK31.22457747
53PHKG11.21472439
54PHKG21.21472439
55NME21.19316150
56MAP3K11.17998204
57RPS6KB21.16961259
58CAMK1D1.16647286
59WNK11.16273326
60ERN11.11047218
61FER1.10355708
62GRK71.08932116
63PDPK11.08308778
64PDK11.04828965
65EEF2K1.04722991
66STK241.04679703
67MUSK1.02647867
68MST41.00839117
69PAK30.98597662
70MYLK0.97735495
71PAK40.93951431
72MAP3K70.93113835
73DMPK0.91982706
74TAOK10.91971627
75FGFR20.91183164
76MAP3K30.91133212
77ALK0.87931845
78RIPK40.87683972
79SGK30.87596337
80PTK20.86178551
81BRAF0.85996454
82KSR10.83929603
83CDK50.83750149
84TAOK30.83680068
85PDK20.80064265
86MAPK120.78801479
87STK110.77263350
88MAP2K10.75190023
89JAK20.74762884
90SGK4940.74450932
91SGK2230.74450932
92PRKAA20.73896686
93FGFR30.73702534
94CDK60.73371415
95PIK3CA0.73288853
96PINK10.72087508
97LATS10.70311592
98EPHA20.70224746
99FGR0.68654449
100CSF1R0.67897831
101AKT20.67605302
102JAK10.66373075
103ILK0.65949217
104PRKD10.65648456
105TIE10.64612597
106EPHB10.64209201
107PRKAA10.64197093
108STK30.62520387
109MST1R0.61153815
110WNK30.61094149
111PDGFRB0.60925658
112LATS20.60453839
113ROCK10.60445454
114MAP3K140.60232356
115STK38L0.60039035
116STK100.59575505
117CDC42BPA0.59009941
118MAPKAPK30.58303417
119MAP3K100.58156961
120PTK2B0.58123643
121NTRK20.57952405
122STK390.57395815
123NEK60.56673889
124DDR20.55682275
125RPS6KB10.52103620
126GRK50.51232960
127HIPK20.50936626
128CAMK2D0.50347500
129MAP2K60.49737360
130MAP3K80.48328750
131EPHA30.48263205
132ERBB30.47637967
133ABL20.47370208
134SGK10.45718809
135TTK0.45183505
136RPS6KA30.44847625
137TESK10.43514147
138MARK20.43333410
139PRKCG0.42359266
140BMX0.41737200
141PRKACG0.41370591
142UHMK10.41339937
143MTOR0.41198820
144RAF10.40115234
145ICK0.39935679
146LRRK20.39809118
147OXSR10.39677872
148ROCK20.39280866
149DAPK10.39202352
150PRKCZ0.39147989
151SGK20.38747771
152CAMK2G0.38657058
153MET0.38614890
154DAPK30.37547717
155PRKG20.34748114
156BMPR20.33873867
157MAP3K60.33677344

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.80295964
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.85422595
3Pentose phosphate pathway_Homo sapiens_hsa000302.68032332
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52125263
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.38962675
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99719824
7Arginine biosynthesis_Homo sapiens_hsa002201.96530140
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95239004
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82864626
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77120352
11Galactose metabolism_Homo sapiens_hsa000521.60791554
12Butanoate metabolism_Homo sapiens_hsa006501.55386956
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52328738
14Insulin secretion_Homo sapiens_hsa049111.51853796
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.50963226
16Synaptic vesicle cycle_Homo sapiens_hsa047211.49745600
17Bile secretion_Homo sapiens_hsa049761.49653116
18Fatty acid degradation_Homo sapiens_hsa000711.45579399
19Propanoate metabolism_Homo sapiens_hsa006401.43784186
20Other glycan degradation_Homo sapiens_hsa005111.42468815
21Thyroid cancer_Homo sapiens_hsa052161.41330052
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39862997
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.38899427
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38488628
25Type II diabetes mellitus_Homo sapiens_hsa049301.38174866
26Fructose and mannose metabolism_Homo sapiens_hsa000511.37829196
27Long-term potentiation_Homo sapiens_hsa047201.35741244
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29055720
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27981099
30Arginine and proline metabolism_Homo sapiens_hsa003301.27395391
31Adherens junction_Homo sapiens_hsa045201.24568669
32Tryptophan metabolism_Homo sapiens_hsa003801.24541659
33GABAergic synapse_Homo sapiens_hsa047271.22160643
34Amoebiasis_Homo sapiens_hsa051461.17906066
35Fatty acid metabolism_Homo sapiens_hsa012121.17228597
36PPAR signaling pathway_Homo sapiens_hsa033201.16909824
37Gastric acid secretion_Homo sapiens_hsa049711.16776269
38Circadian rhythm_Homo sapiens_hsa047101.16646771
39Amphetamine addiction_Homo sapiens_hsa050311.16397243
40Focal adhesion_Homo sapiens_hsa045101.16281565
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14027907
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11650763
43Pyruvate metabolism_Homo sapiens_hsa006201.10420905
44Circadian entrainment_Homo sapiens_hsa047131.10410825
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09143939
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08172892
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06293884
48Renin secretion_Homo sapiens_hsa049241.05781098
49Tight junction_Homo sapiens_hsa045301.05161404
50Glucagon signaling pathway_Homo sapiens_hsa049221.04074965
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.02923517
52Dopaminergic synapse_Homo sapiens_hsa047281.02716585
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02682415
54Olfactory transduction_Homo sapiens_hsa047401.01753883
55Endometrial cancer_Homo sapiens_hsa052131.01312786
56Cocaine addiction_Homo sapiens_hsa050301.00595869
57Vitamin B6 metabolism_Homo sapiens_hsa007501.00204752
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00201994
59Salivary secretion_Homo sapiens_hsa049700.99727162
60Insulin resistance_Homo sapiens_hsa049310.97309366
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95868882
62Chronic myeloid leukemia_Homo sapiens_hsa052200.93312426
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93270836
64Cholinergic synapse_Homo sapiens_hsa047250.91569514
65Carbon metabolism_Homo sapiens_hsa012000.90703272
66Sulfur metabolism_Homo sapiens_hsa009200.89316384
67Glutamatergic synapse_Homo sapiens_hsa047240.89215992
68Proteoglycans in cancer_Homo sapiens_hsa052050.88435370
69Morphine addiction_Homo sapiens_hsa050320.87453269
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87275969
71Pancreatic cancer_Homo sapiens_hsa052120.86483464
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.86102614
73Glycerolipid metabolism_Homo sapiens_hsa005610.85965009
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85735362
75Thyroid hormone synthesis_Homo sapiens_hsa049180.85211238
76Pancreatic secretion_Homo sapiens_hsa049720.85024147
77Renal cell carcinoma_Homo sapiens_hsa052110.84815570
78Dorso-ventral axis formation_Homo sapiens_hsa043200.84483799
79Cardiac muscle contraction_Homo sapiens_hsa042600.83012492
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83006476
81HIF-1 signaling pathway_Homo sapiens_hsa040660.82798965
82Acute myeloid leukemia_Homo sapiens_hsa052210.82685524
83Estrogen signaling pathway_Homo sapiens_hsa049150.82314957
84mTOR signaling pathway_Homo sapiens_hsa041500.80978644
85Oxytocin signaling pathway_Homo sapiens_hsa049210.80121252
86Renin-angiotensin system_Homo sapiens_hsa046140.79806090
87Fatty acid elongation_Homo sapiens_hsa000620.78839443
88Starch and sucrose metabolism_Homo sapiens_hsa005000.77395278
89Fat digestion and absorption_Homo sapiens_hsa049750.76918767
90Non-small cell lung cancer_Homo sapiens_hsa052230.76731506
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76625028
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76573869
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76370913
94Insulin signaling pathway_Homo sapiens_hsa049100.75749908
95Fatty acid biosynthesis_Homo sapiens_hsa000610.72874171
96GnRH signaling pathway_Homo sapiens_hsa049120.72287368
97ABC transporters_Homo sapiens_hsa020100.70308346
98Platelet activation_Homo sapiens_hsa046110.69709574
99AMPK signaling pathway_Homo sapiens_hsa041520.69050670
100Glioma_Homo sapiens_hsa052140.68674996
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67742023
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66973591
103Mineral absorption_Homo sapiens_hsa049780.66888045
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66120275
105Dilated cardiomyopathy_Homo sapiens_hsa054140.65860082
106Systemic lupus erythematosus_Homo sapiens_hsa053220.65240053
107Nicotine addiction_Homo sapiens_hsa050330.64306019
108Selenocompound metabolism_Homo sapiens_hsa004500.63918680
109Gap junction_Homo sapiens_hsa045400.63849896
110Biosynthesis of amino acids_Homo sapiens_hsa012300.62541587
111Viral carcinogenesis_Homo sapiens_hsa052030.61876759
112cAMP signaling pathway_Homo sapiens_hsa040240.61691506
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60233454
114Bladder cancer_Homo sapiens_hsa052190.59979208
115Phenylalanine metabolism_Homo sapiens_hsa003600.59744657
116Small cell lung cancer_Homo sapiens_hsa052220.59562121
117Sphingolipid metabolism_Homo sapiens_hsa006000.59270556
118beta-Alanine metabolism_Homo sapiens_hsa004100.59035139
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58868944
120B cell receptor signaling pathway_Homo sapiens_hsa046620.57927545
121VEGF signaling pathway_Homo sapiens_hsa043700.56169131
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.55902820
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.55255836
124Caffeine metabolism_Homo sapiens_hsa002320.54847924
125Legionellosis_Homo sapiens_hsa051340.54398245
126Prion diseases_Homo sapiens_hsa050200.54350014
127Calcium signaling pathway_Homo sapiens_hsa040200.54091983
128ErbB signaling pathway_Homo sapiens_hsa040120.54072912
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.53680010
130Complement and coagulation cascades_Homo sapiens_hsa046100.53544135
131Lysosome_Homo sapiens_hsa041420.53171269
132Peroxisome_Homo sapiens_hsa041460.53007205
133Long-term depression_Homo sapiens_hsa047300.51359695
134Glutathione metabolism_Homo sapiens_hsa004800.51160251
135Histidine metabolism_Homo sapiens_hsa003400.51154659
136Endocytosis_Homo sapiens_hsa041440.51090371
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50718744
138Vibrio cholerae infection_Homo sapiens_hsa051100.50124130
139Prostate cancer_Homo sapiens_hsa052150.49519697
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49205450
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.48494832
142FoxO signaling pathway_Homo sapiens_hsa040680.47611302
143Lysine degradation_Homo sapiens_hsa003100.47549742
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45839132
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45691317
146Taste transduction_Homo sapiens_hsa047420.45513279
147Inositol phosphate metabolism_Homo sapiens_hsa005620.44515888
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44426898
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.44418530

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