SETD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.17163914
2folic acid-containing compound biosynthetic process (GO:0009396)4.97050467
3ribosomal small subunit assembly (GO:0000028)4.59269132
4maturation of SSU-rRNA (GO:0030490)4.49226833
5viral transcription (GO:0019083)4.48171835
6DNA strand elongation involved in DNA replication (GO:0006271)4.44542379
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.44034354
8translational termination (GO:0006415)4.43727813
9DNA replication initiation (GO:0006270)4.42092622
10DNA unwinding involved in DNA replication (GO:0006268)4.30418189
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23681583
12chaperone-mediated protein transport (GO:0072321)4.20547814
13DNA strand elongation (GO:0022616)4.20050293
14formation of translation preinitiation complex (GO:0001731)4.09773704
15telomere maintenance via semi-conservative replication (GO:0032201)4.09361795
16translational elongation (GO:0006414)4.07383276
17ATP synthesis coupled proton transport (GO:0015986)4.07366803
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.07366803
19nucleobase biosynthetic process (GO:0046112)3.97045149
20protein complex biogenesis (GO:0070271)3.89669798
21translational initiation (GO:0006413)3.88636955
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.85830337
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.85830337
24NADH dehydrogenase complex assembly (GO:0010257)3.85830337
25folic acid metabolic process (GO:0046655)3.83125081
26mitochondrial respiratory chain complex assembly (GO:0033108)3.82863748
27ribosomal small subunit biogenesis (GO:0042274)3.80116499
28water-soluble vitamin biosynthetic process (GO:0042364)3.77714675
29DNA replication checkpoint (GO:0000076)3.76286673
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76214988
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.74637631
32regulation of mitochondrial translation (GO:0070129)3.74624576
33ribosome assembly (GO:0042255)3.73223402
34protein localization to kinetochore (GO:0034501)3.72588441
35respiratory chain complex IV assembly (GO:0008535)3.71034146
36termination of RNA polymerase III transcription (GO:0006386)3.70492217
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.70492217
38mitotic nuclear envelope disassembly (GO:0007077)3.69382952
39IMP biosynthetic process (GO:0006188)3.69052982
40pteridine-containing compound biosynthetic process (GO:0042559)3.68156705
41ribosomal large subunit biogenesis (GO:0042273)3.67915503
42protein targeting to ER (GO:0045047)3.63847294
43cotranslational protein targeting to membrane (GO:0006613)3.63478862
44purine nucleobase biosynthetic process (GO:0009113)3.62335212
45ribonucleoprotein complex biogenesis (GO:0022613)3.59767209
46ribosome biogenesis (GO:0042254)3.57521103
47cytochrome complex assembly (GO:0017004)3.57304278
48glycine metabolic process (GO:0006544)3.53520504
49telomere maintenance via recombination (GO:0000722)3.51227090
50mitotic metaphase plate congression (GO:0007080)3.51044426
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.50456541
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47210687
53IMP metabolic process (GO:0046040)3.46501269
54protein localization to endoplasmic reticulum (GO:0070972)3.45752594
55viral life cycle (GO:0019058)3.42554694
56membrane disassembly (GO:0030397)3.41030916
57nuclear envelope disassembly (GO:0051081)3.41030916
58cellular protein complex disassembly (GO:0043624)3.36232678
59nuclear pore organization (GO:0006999)3.33756100
60respiratory electron transport chain (GO:0022904)3.30998831
61DNA replication-dependent nucleosome organization (GO:0034723)3.30761616
62DNA replication-dependent nucleosome assembly (GO:0006335)3.30761616
63mitotic recombination (GO:0006312)3.29980927
64telomere maintenance via telomere lengthening (GO:0010833)3.29692938
65electron transport chain (GO:0022900)3.27269929
66tetrahydrofolate metabolic process (GO:0046653)3.25051373
67rRNA processing (GO:0006364)3.23315572
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23312657
69pseudouridine synthesis (GO:0001522)3.22602703
70protein localization to chromosome, centromeric region (GO:0071459)3.21517458
71rRNA methylation (GO:0031167)3.21457725
72nuclear pore complex assembly (GO:0051292)3.19443567
73metaphase plate congression (GO:0051310)3.19300360
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18947140
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18414983
76regulation of translational fidelity (GO:0006450)3.17231474
77protein targeting to membrane (GO:0006612)3.16856807
78rRNA metabolic process (GO:0016072)3.12804824
79kinetochore assembly (GO:0051382)3.06287375
80piRNA metabolic process (GO:0034587)3.05631638
81DNA duplex unwinding (GO:0032508)3.04392010
82protein complex disassembly (GO:0043241)3.03299462
83meiotic chromosome segregation (GO:0045132)3.02605204
84replication fork processing (GO:0031297)3.02501686
85nuclear-transcribed mRNA catabolic process (GO:0000956)3.01941556
86DNA geometric change (GO:0032392)3.01360894
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00393943
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00393943
89histone exchange (GO:0043486)2.99604718
90protein neddylation (GO:0045116)2.98156084
91pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.97349864
92folic acid-containing compound metabolic process (GO:0006760)2.97165503
93serine family amino acid biosynthetic process (GO:0009070)2.95547317
94translation (GO:0006412)2.94461875
95chromatin remodeling at centromere (GO:0031055)2.94269700
96pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93518540
97establishment of integrated proviral latency (GO:0075713)2.92680964
98peptidyl-histidine modification (GO:0018202)2.92535715
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92276595
100nucleotide-excision repair, DNA gap filling (GO:0006297)2.90210544
101RNA catabolic process (GO:0006401)2.88659945
102mRNA catabolic process (GO:0006402)2.88468450
103CENP-A containing nucleosome assembly (GO:0034080)2.87308427
104macromolecular complex disassembly (GO:0032984)2.86351646
105cornea development in camera-type eye (GO:0061303)2.85111584
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.84198583
107ncRNA processing (GO:0034470)2.81872130
108tRNA processing (GO:0008033)2.81634796
109spliceosomal snRNP assembly (GO:0000387)2.81240294
110tRNA aminoacylation for protein translation (GO:0006418)2.80619279
111negative regulation of RNA splicing (GO:0033119)2.79595377
112mitotic chromosome condensation (GO:0007076)2.78816309
113regulation of histone H3-K9 methylation (GO:0051570)2.78010983
114behavioral response to nicotine (GO:0035095)2.77609800
115kinetochore organization (GO:0051383)2.77265763
116ncRNA metabolic process (GO:0034660)2.77010015
117one-carbon metabolic process (GO:0006730)2.76897519
118DNA replication-independent nucleosome assembly (GO:0006336)2.76420313
119DNA replication-independent nucleosome organization (GO:0034724)2.76420313
120cellular component biogenesis (GO:0044085)2.76065457
121protein targeting to mitochondrion (GO:0006626)2.75997734
122pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.75240008
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74350895
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.74350895
125pteridine-containing compound metabolic process (GO:0042558)2.72132590
126DNA double-strand break processing (GO:0000729)2.71785429
127amino acid activation (GO:0043038)2.71453652
128tRNA aminoacylation (GO:0043039)2.71453652
129L-serine metabolic process (GO:0006563)2.70189224
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.68709075
131deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.68465052
132regulation of helicase activity (GO:0051095)2.67519913
133somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66622459
134isotype switching (GO:0045190)2.66622459
135somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66622459
136serine family amino acid metabolic process (GO:0009069)2.66604598
137rRNA modification (GO:0000154)2.66178638
138telomere maintenance (GO:0000723)2.65651375
139establishment of protein localization to mitochondrion (GO:0072655)2.65554359
140mitotic G1 DNA damage checkpoint (GO:0031571)2.65498862
141telomere organization (GO:0032200)2.65262367
142mitochondrial RNA metabolic process (GO:0000959)2.63998865
143DNA catabolic process, exonucleolytic (GO:0000738)2.60374045
144spliceosomal complex assembly (GO:0000245)2.57064634
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57022746
146regulation of mitotic spindle checkpoint (GO:1903504)2.57022746
147protein localization to mitochondrion (GO:0070585)2.55299163
148tRNA metabolic process (GO:0006399)2.54111496
149synapsis (GO:0007129)2.53253997
150reciprocal meiotic recombination (GO:0007131)2.51087461
151reciprocal DNA recombination (GO:0035825)2.51087461
152recombinational repair (GO:0000725)2.49638409
153proteasome assembly (GO:0043248)2.48476186
154male meiosis I (GO:0007141)2.48413558
155double-strand break repair via homologous recombination (GO:0000724)2.48102143
156tRNA modification (GO:0006400)2.47577604
157maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47410329
158epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47348541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.38583820
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.36214489
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91171947
4* FOXM1_23109430_ChIP-Seq_U2OS_Human3.06098751
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01833277
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92251688
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76456229
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71116641
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59846345
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52222806
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49128106
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.48723116
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.47462859
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.41561144
15XRN2_22483619_ChIP-Seq_HELA_Human2.26040103
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24156750
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23104809
18VDR_23849224_ChIP-Seq_CD4+_Human2.06064217
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00775139
20E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99610709
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97469884
22MYC_22102868_ChIP-Seq_BL_Human1.95679223
23EWS_26573619_Chip-Seq_HEK293_Human1.94033618
24AR_21909140_ChIP-Seq_LNCAP_Human1.93814557
25FUS_26573619_Chip-Seq_HEK293_Human1.93225139
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91187541
27DCP1A_22483619_ChIP-Seq_HELA_Human1.90900458
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.85521199
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.83909078
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83810171
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81540019
32FOXP3_21729870_ChIP-Seq_TREG_Human1.80728678
33* GABP_19822575_ChIP-Seq_HepG2_Human1.77825244
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74801794
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74279969
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74097951
37* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72611751
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72125465
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69129038
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63586141
41TTF2_22483619_ChIP-Seq_HELA_Human1.63188318
42CIITA_25753668_ChIP-Seq_RAJI_Human1.63157962
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62841268
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60552149
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60506474
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.50665046
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.46633318
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45533312
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44667006
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44536709
51KDM5A_27292631_Chip-Seq_BREAST_Human1.44137407
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42864293
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40552671
54VDR_22108803_ChIP-Seq_LS180_Human1.40256863
55ZNF274_21170338_ChIP-Seq_K562_Hela1.39327215
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.39262641
57IGF1R_20145208_ChIP-Seq_DFB_Human1.36034468
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35304826
59* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34781450
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32709763
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32490412
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31926402
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31613499
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31433936
65* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30122596
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27722778
67ELK1_19687146_ChIP-ChIP_HELA_Human1.27378542
68* SRF_21415370_ChIP-Seq_HL-1_Mouse1.27294041
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25660786
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25234097
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25194446
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.23190814
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22822610
74TFEB_21752829_ChIP-Seq_HELA_Human1.18199210
75* VDR_21846776_ChIP-Seq_THP-1_Human1.16900348
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15513275
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15360866
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15148190
79PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15064833
80* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14512520
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14448006
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13497180
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12427960
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12420197
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12279622
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12166382
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11342950
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09642861
89TP53_22573176_ChIP-Seq_HFKS_Human1.06687526
90ZNF263_19887448_ChIP-Seq_K562_Human1.06354688
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05761901
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05247825
93RXR_22158963_ChIP-Seq_LIVER_Mouse1.03936769
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03665733
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00617775
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98934311
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98284085
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97313787
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96998402
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96359071
101GATA1_22025678_ChIP-Seq_K562_Human0.95596697
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95379541
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95112057
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94929810
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94573389
106FOXP1_21924763_ChIP-Seq_HESCs_Human0.91989749
107IRF1_19129219_ChIP-ChIP_H3396_Human0.91905364
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91085900
109BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90292038
110MYC_18940864_ChIP-ChIP_HL60_Human0.89695946
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.88955391
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88585320
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88420905
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88183151
115RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88076844
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87317755
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83635696
118EZH2_22144423_ChIP-Seq_EOC_Human0.82236476
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82075721
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81699042
121SPI1_23547873_ChIP-Seq_NB4_Human0.81475967
122* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81406473
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78437888
124NANOG_16153702_ChIP-ChIP_HESCs_Human0.78126367
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76304379
126RNF2_27304074_Chip-Seq_NSC_Mouse0.73501387
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.73167269
128ERA_21632823_ChIP-Seq_H3396_Human0.72685974
129FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70444413
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.70444413
131* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68502192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.92579126
2MP0003693_abnormal_embryo_hatching4.59660574
3MP0004957_abnormal_blastocyst_morpholog4.10758684
4MP0010094_abnormal_chromosome_stability3.73286077
5MP0003806_abnormal_nucleotide_metabolis3.65775133
6MP0008057_abnormal_DNA_replication3.62431427
7MP0003111_abnormal_nucleus_morphology3.58754921
8MP0008877_abnormal_DNA_methylation3.39519377
9MP0003077_abnormal_cell_cycle3.30803536
10MP0002139_abnormal_hepatobiliary_system2.84949535
11MP0008058_abnormal_DNA_repair2.74510960
12MP0010352_gastrointestinal_tract_polyps2.60336949
13MP0003787_abnormal_imprinting2.58346624
14MP0005360_urolithiasis2.42605904
15MP0001188_hyperpigmentation2.42130502
16MP0008789_abnormal_olfactory_epithelium2.35440144
17MP0005365_abnormal_bile_salt2.33873088
18MP0002638_abnormal_pupillary_reflex2.33724653
19MP0002396_abnormal_hematopoietic_system2.25667585
20MP0008007_abnormal_cellular_replicative2.22289930
21MP0005085_abnormal_gallbladder_physiolo2.13966021
22MP0001730_embryonic_growth_arrest2.11424572
23MP0003136_yellow_coat_color1.89502347
24MP0002160_abnormal_reproductive_system1.89454141
25MP0002938_white_spotting1.87404693
26MP0000350_abnormal_cell_proliferation1.86782762
27MP0005394_taste/olfaction_phenotype1.81811997
28MP0005499_abnormal_olfactory_system1.81811997
29MP0008932_abnormal_embryonic_tissue1.80097790
30MP0000490_abnormal_crypts_of1.79431423
31MP0003186_abnormal_redox_activity1.74885373
32MP0002163_abnormal_gland_morphology1.72289215
33MP0003121_genomic_imprinting1.71326928
34MP0005083_abnormal_biliary_tract1.68698031
35MP0005174_abnormal_tail_pigmentation1.60615665
36MP0009840_abnormal_foam_cell1.59740592
37MP0010307_abnormal_tumor_latency1.59639998
38MP0008875_abnormal_xenobiotic_pharmacok1.51227098
39MP0002837_dystrophic_cardiac_calcinosis1.50591060
40MP0008995_early_reproductive_senescence1.49686891
41MP0001697_abnormal_embryo_size1.46079273
42MP0002080_prenatal_lethality1.45994736
43MP0005389_reproductive_system_phenotype1.43174599
44MP0003656_abnormal_erythrocyte_physiolo1.42939083
45MP0003705_abnormal_hypodermis_morpholog1.42570466
46MP0003718_maternal_effect1.41874370
47MP0000631_abnormal_neuroendocrine_gland1.41152835
48MP0005380_embryogenesis_phenotype1.40265739
49MP0001672_abnormal_embryogenesis/_devel1.40265739
50MP0002019_abnormal_tumor_incidence1.39763813
51MP0001485_abnormal_pinna_reflex1.39402037
52MP0006036_abnormal_mitochondrial_physio1.38662406
53MP0001986_abnormal_taste_sensitivity1.37855827
54MP0010234_abnormal_vibrissa_follicle1.36872942
55MP0002086_abnormal_extraembryonic_tissu1.32497915
56MP0005397_hematopoietic_system_phenotyp1.29357277
57MP0001545_abnormal_hematopoietic_system1.29357277
58MP0003123_paternal_imprinting1.29267553
59MP0001666_abnormal_nutrient_absorption1.28616667
60MP0005551_abnormal_eye_electrophysiolog1.28332645
61MP0003763_abnormal_thymus_physiology1.28058854
62MP0006072_abnormal_retinal_apoptosis1.27704631
63MP0003786_premature_aging1.27375043
64MP0003984_embryonic_growth_retardation1.26387717
65MP0001919_abnormal_reproductive_system1.24523651
66MP0002088_abnormal_embryonic_growth/wei1.23550833
67MP0000313_abnormal_cell_death1.22850453
68MP0002084_abnormal_developmental_patter1.22735606
69MP0003937_abnormal_limbs/digits/tail_de1.20427155
70MP0004133_heterotaxia1.17530797
71MP0001929_abnormal_gametogenesis1.17499513
72MP0005084_abnormal_gallbladder_morpholo1.14770849
73MP0002085_abnormal_embryonic_tissue1.13969465
74MP0005075_abnormal_melanosome_morpholog1.13398611
75MP0005076_abnormal_cell_differentiation1.13076960
76MP0003122_maternal_imprinting1.12891989
77MP0001293_anophthalmia1.12706068
78MP0005266_abnormal_metabolism1.12418838
79MP0000609_abnormal_liver_physiology1.12157758
80MP0005379_endocrine/exocrine_gland_phen1.11649268
81MP0003646_muscle_fatigue1.11438837
82MP0001984_abnormal_olfaction1.10535506
83MP0004197_abnormal_fetal_growth/weight/1.10189421
84MP0000358_abnormal_cell_content/1.09912403
85MP0000049_abnormal_middle_ear1.07796416
86MP0009333_abnormal_splenocyte_physiolog1.07704126
87MP0003880_abnormal_central_pattern1.06241277
88MP0003252_abnormal_bile_duct1.06054779
89MP0001853_heart_inflammation1.05419809
90MP0005319_abnormal_enzyme/_coenzyme1.04746135
91MP0000778_abnormal_nervous_system1.04086157
92MP0004142_abnormal_muscle_tone1.03526481
93MP0004808_abnormal_hematopoietic_stem1.02939373
94MP0002722_abnormal_immune_system1.02938799
95MP0009672_abnormal_birth_weight1.02845735
96MP0000703_abnormal_thymus_morphology1.02560715
97MP0002398_abnormal_bone_marrow1.02315189
98MP0006035_abnormal_mitochondrial_morpho1.02118351
99MP0002876_abnormal_thyroid_physiology1.01621321
100MP0002277_abnormal_respiratory_mucosa1.00956229
101MP0000689_abnormal_spleen_morphology0.98817736
102MP0003567_abnormal_fetal_cardiomyocyte0.98702496
103MP0003698_abnormal_male_reproductive0.98568766
104MP0000598_abnormal_liver_morphology0.96506143
105MP0005023_abnormal_wound_healing0.95286309
106MP0003878_abnormal_ear_physiology0.94923706
107MP0005377_hearing/vestibular/ear_phenot0.94923706
108MP0005220_abnormal_exocrine_pancreas0.94671867
109MP0003890_abnormal_embryonic-extraembry0.93035917
110MP0002233_abnormal_nose_morphology0.92938023
111MP0001286_abnormal_eye_development0.92916330
112MP0004264_abnormal_extraembryonic_tissu0.92468377
113MP0006054_spinal_hemorrhage0.91969832
114MP0010329_abnormal_lipoprotein_level0.89926090
115MP0005501_abnormal_skin_physiology0.89809422
116MP0000372_irregular_coat_pigmentation0.88826278
117MP0000566_synostosis0.87717215
118MP0005332_abnormal_amino_acid0.87050573
119MP0002095_abnormal_skin_pigmentation0.86489201
120MP0001968_abnormal_touch/_nociception0.85160882
121MP0004885_abnormal_endolymph0.83749654
122MP0003315_abnormal_perineum_morphology0.82836514
123MP0003566_abnormal_cell_adhesion0.82431462
124MP0003868_abnormal_feces_composition0.81189916
125MP0009046_muscle_twitch0.80874635
126MP0001324_abnormal_eye_pigmentation0.80350172
127MP0003283_abnormal_digestive_organ0.80206132
128MP0010030_abnormal_orbit_morphology0.80014402
129MP0003221_abnormal_cardiomyocyte_apopto0.79734721
130MP0002132_abnormal_respiratory_system0.79535826
131MP0002429_abnormal_blood_cell0.79437523
132MP0001764_abnormal_homeostasis0.79082920
133MP0002102_abnormal_ear_morphology0.77806849
134MP0009053_abnormal_anal_canal0.77440659
135MP0002272_abnormal_nervous_system0.77388618
136MP0002234_abnormal_pharynx_morphology0.77316864
137MP0004043_abnormal_pH_regulation0.76841228
138MP0000858_altered_metastatic_potential0.76350058
139MP0008872_abnormal_physiological_respon0.75995094
140MP0001915_intracranial_hemorrhage0.74892113
141MP0001119_abnormal_female_reproductive0.74553446
142MP0002736_abnormal_nociception_after0.74450641
143MP0001145_abnormal_male_reproductive0.74051326
144MP0009643_abnormal_urine_homeostasis0.73961519
145MP0005195_abnormal_posterior_eye0.73919204
146MP0005384_cellular_phenotype0.72412257
147MP0000477_abnormal_intestine_morphology0.72229344
148MP0001502_abnormal_circadian_rhythm0.71707169
149MP0000537_abnormal_urethra_morphology0.71586736
150MP0006276_abnormal_autonomic_nervous0.71025572
151MP0003755_abnormal_palate_morphology0.70963173
152MP0002210_abnormal_sex_determination0.70543558
153MP0005621_abnormal_cell_physiology0.70423023
154MP0002697_abnormal_eye_size0.69911398
155MP0001346_abnormal_lacrimal_gland0.69375635
156MP0005253_abnormal_eye_physiology0.69153656
157MP0009379_abnormal_foot_pigmentation0.68922632
158MP0003191_abnormal_cellular_cholesterol0.67858509
159MP0002184_abnormal_innervation0.67250553
160MP0000371_diluted_coat_color0.67124276
161MP0003119_abnormal_digestive_system0.66354106
162MP0004185_abnormal_adipocyte_glucose0.66194657
163MP0002653_abnormal_ependyma_morphology0.65812853
164MP0000685_abnormal_immune_system0.65280948
165MP0005391_vision/eye_phenotype0.64597011
166MP0002269_muscular_atrophy0.64542401
167MP0002796_impaired_skin_barrier0.64410584
168MP0009250_abnormal_appendicular_skeleto0.64001992
169MP0002166_altered_tumor_susceptibility0.63706093
170MP0000653_abnormal_sex_gland0.63640201
171MP0005646_abnormal_pituitary_gland0.63386273
172MP0000015_abnormal_ear_pigmentation0.63307111
173MP0002752_abnormal_somatic_nervous0.63260084
174MP0000716_abnormal_immune_system0.62702386
175MP0005410_abnormal_fertilization0.62477786

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.76637780
2Abnormal number of erythroid precursors (HP:0012131)5.49290668
3Reticulocytopenia (HP:0001896)4.41620363
4Birth length less than 3rd percentile (HP:0003561)4.33664149
5Oral leukoplakia (HP:0002745)4.08694261
6Increased hepatocellular lipid droplets (HP:0006565)3.53966660
7Macrocytic anemia (HP:0001972)3.47297054
8Acute necrotizing encephalopathy (HP:0006965)3.37999248
9Ependymoma (HP:0002888)3.36020290
10Aplastic anemia (HP:0001915)3.31345698
11Abnormality of pyrimidine metabolism (HP:0004353)3.29878743
12Colon cancer (HP:0003003)3.25126814
13Pallor (HP:0000980)3.23676198
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.20833282
15Lipid accumulation in hepatocytes (HP:0006561)3.19017687
16Mitochondrial inheritance (HP:0001427)3.18568377
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.14527124
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.10843005
19Rhabdomyosarcoma (HP:0002859)3.04834237
20Abnormal mitochondria in muscle tissue (HP:0008316)2.99984633
21Hypobetalipoproteinemia (HP:0003563)2.98887383
22Acute encephalopathy (HP:0006846)2.98019341
23Breast hypoplasia (HP:0003187)2.96320253
24Intrahepatic cholestasis (HP:0001406)2.95061929
25Spastic diplegia (HP:0001264)2.94064152
26Pancreatic fibrosis (HP:0100732)2.91614502
27Multiple enchondromatosis (HP:0005701)2.91449868
28Increased CSF lactate (HP:0002490)2.89819403
29Molar tooth sign on MRI (HP:0002419)2.86825413
30Abnormality of midbrain morphology (HP:0002418)2.86825413
31Renal Fanconi syndrome (HP:0001994)2.85381391
32Abnormality of reticulocytes (HP:0004312)2.83905868
33Rib fusion (HP:0000902)2.80869717
34Medulloblastoma (HP:0002885)2.79431567
35Progressive macrocephaly (HP:0004481)2.77105099
36Basal cell carcinoma (HP:0002671)2.72788418
37Pancreatic cysts (HP:0001737)2.70520970
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.68567599
39Selective tooth agenesis (HP:0001592)2.67508392
40Hepatocellular necrosis (HP:0001404)2.62565620
41Thrombocytosis (HP:0001894)2.60801429
42Nephronophthisis (HP:0000090)2.59807890
433-Methylglutaconic aciduria (HP:0003535)2.59199540
44Agnosia (HP:0010524)2.58838774
45True hermaphroditism (HP:0010459)2.55299725
46Progressive muscle weakness (HP:0003323)2.54793871
47Hyperglycinemia (HP:0002154)2.50438879
48Degeneration of anterior horn cells (HP:0002398)2.45169307
49Abnormality of the anterior horn cell (HP:0006802)2.45169307
50Absent thumb (HP:0009777)2.44832707
51Septo-optic dysplasia (HP:0100842)2.44295660
52Hyperammonemia (HP:0001987)2.43808188
53Medial flaring of the eyebrow (HP:0010747)2.41228798
54Rough bone trabeculation (HP:0100670)2.40975318
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40601170
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40601170
57Megaloblastic anemia (HP:0001889)2.36025108
58Abnormality of lateral ventricle (HP:0030047)2.35960217
59Microretrognathia (HP:0000308)2.32698332
60Triphalangeal thumb (HP:0001199)2.30916569
61Increased intramyocellular lipid droplets (HP:0012240)2.25930640
62Myelodysplasia (HP:0002863)2.25409497
63Premature ovarian failure (HP:0008209)2.23714083
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23370306
65Abnormality of renal resorption (HP:0011038)2.22833516
66Neoplasm of striated muscle (HP:0009728)2.20762030
67Abnormality of the labia minora (HP:0012880)2.20130769
68Abnormality of chromosome stability (HP:0003220)2.19575857
69Patellar aplasia (HP:0006443)2.17886475
70Carpal bone hypoplasia (HP:0001498)2.17493645
71Neoplasm of the pancreas (HP:0002894)2.16592712
72Congenital stationary night blindness (HP:0007642)2.15324692
73Hyperglycinuria (HP:0003108)2.12756581
74Premature graying of hair (HP:0002216)2.12628878
75Abnormality of the preputium (HP:0100587)2.11278218
76Hypoplasia of the radius (HP:0002984)2.09808377
77Respiratory difficulties (HP:0002880)2.09752417
78Ectopic kidney (HP:0000086)2.09529858
79Cellular immunodeficiency (HP:0005374)2.07482890
80Biliary tract neoplasm (HP:0100574)2.07247277
81Angiofibromas (HP:0010615)2.06830659
82Adenoma sebaceum (HP:0009720)2.06830659
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05951363
84Methylmalonic acidemia (HP:0002912)2.05166312
85Chromsome breakage (HP:0040012)2.04912140
86Abnormality of serine family amino acid metabolism (HP:0010894)2.03999486
87Abnormality of glycine metabolism (HP:0010895)2.03999486
88Hypoglycemic coma (HP:0001325)2.03094058
89Nephrogenic diabetes insipidus (HP:0009806)2.02852587
90Increased serum ferritin (HP:0003281)2.02604426
91Lactic acidosis (HP:0003128)2.02487160
92Delayed CNS myelination (HP:0002188)2.01598021
93Dicarboxylic aciduria (HP:0003215)2.01308883
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01308883
95Pendular nystagmus (HP:0012043)2.00936293
96Pancytopenia (HP:0001876)2.00415995
97Amaurosis fugax (HP:0100576)2.00322273
98Sclerocornea (HP:0000647)2.00065256
99Abnormality of the renal medulla (HP:0100957)1.99970319
100Abnormality of serum amino acid levels (HP:0003112)1.99878829
101Abnormality of sulfur amino acid metabolism (HP:0004339)1.99623608
102Neoplasm of the oral cavity (HP:0100649)1.99095784
103Rectal fistula (HP:0100590)1.97763580
104Rectovaginal fistula (HP:0000143)1.97763580
105Congenital primary aphakia (HP:0007707)1.96858907
106Aplasia/Hypoplasia of the patella (HP:0006498)1.96205719
107Reticulocytosis (HP:0001923)1.95191465
108Optic nerve coloboma (HP:0000588)1.94756413
109Chronic hepatic failure (HP:0100626)1.94523908
110Trismus (HP:0000211)1.93876160
111Nausea (HP:0002018)1.93325963
112Gait imbalance (HP:0002141)1.92864884
113Volvulus (HP:0002580)1.92339938
114Cleft eyelid (HP:0000625)1.91984338
115Cerebral edema (HP:0002181)1.91913056
116Cystic liver disease (HP:0006706)1.91671599
117Male pseudohermaphroditism (HP:0000037)1.91663328
118Methylmalonic aciduria (HP:0012120)1.91093734
119Hypolipoproteinemia (HP:0010981)1.90939585
120Secondary amenorrhea (HP:0000869)1.90931588
121Abnormality of alanine metabolism (HP:0010916)1.89949101
122Hyperalaninemia (HP:0003348)1.89949101
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89949101
124Poikiloderma (HP:0001029)1.89722088
125Optic disc pallor (HP:0000543)1.89477162
126Increased serum lactate (HP:0002151)1.89378228
127Xanthomatosis (HP:0000991)1.89176890
128Abnormality of homocysteine metabolism (HP:0010919)1.88312740
129Homocystinuria (HP:0002156)1.88312740
130Abnormality of methionine metabolism (HP:0010901)1.88311677
131Testicular atrophy (HP:0000029)1.88162427
132Reduced antithrombin III activity (HP:0001976)1.88080976
133Prominent nose (HP:0000448)1.87762305
134Exertional dyspnea (HP:0002875)1.85859091
135Abnormality of iron homeostasis (HP:0011031)1.85402762
136Hyperbilirubinemia (HP:0002904)1.85245012
137Abnormality of transition element cation homeostasis (HP:0011030)1.85236994
138Sloping forehead (HP:0000340)1.85216772
139Microvesicular hepatic steatosis (HP:0001414)1.84479604
140Short thumb (HP:0009778)1.83917154
141Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82653440
142Ketosis (HP:0001946)1.81673939
143Increased muscle lipid content (HP:0009058)1.81351509
144Bone marrow hypocellularity (HP:0005528)1.79972723
145Preaxial hand polydactyly (HP:0001177)1.79381486
146Horseshoe kidney (HP:0000085)1.79063369
147IgM deficiency (HP:0002850)1.78583488
148Abnormality of the ileum (HP:0001549)1.78414569
149Astrocytoma (HP:0009592)1.78218647
150Abnormality of the astrocytes (HP:0100707)1.78218647
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.77556879
152Ragged-red muscle fibers (HP:0003200)1.77514059
153Anophthalmia (HP:0000528)1.77496272
154Abnormality of nucleobase metabolism (HP:0010932)1.77176732
155Absent/shortened dynein arms (HP:0200106)1.76998668
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.76998668
157Meckel diverticulum (HP:0002245)1.76801915
158Abnormality of DNA repair (HP:0003254)1.76067358
159Poikilocytosis (HP:0004447)1.74568495
160Acanthocytosis (HP:0001927)1.74292057
161Hepatic necrosis (HP:0002605)1.74191689
162Exercise intolerance (HP:0003546)1.74090654
163Optic nerve hypoplasia (HP:0000609)1.73585215
164Oligodactyly (hands) (HP:0001180)1.73571608
165Abnormality of the renal collecting system (HP:0004742)1.73027849
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.72836550
167Facial hemangioma (HP:0000329)1.72440821
168Abnormal rod and cone electroretinograms (HP:0008323)1.71082169
169Glycosuria (HP:0003076)1.70252301
170Abnormality of urine glucose concentration (HP:0011016)1.70252301
171Abnormal biliary tract physiology (HP:0012439)1.70018821
172Neoplasm of the colon (HP:0100273)1.69580655
173Neoplasm of the rectum (HP:0100743)1.68594201
174Lethargy (HP:0001254)1.66576513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.03362309
2CDC73.75872101
3BUB13.10654766
4EIF2AK13.04791823
5NME23.03215830
6VRK22.87855036
7SCYL22.65342054
8NEK22.56390715
9EIF2AK32.49562427
10BCKDK2.47279096
11STK162.30009661
12BMPR1B2.29553975
13NEK12.24392977
14RPS6KB22.20365749
15CDK192.19831332
16NUAK12.08289950
17EEF2K2.08124390
18WNK42.07019472
19FRK2.05490084
20PKN22.02334495
21MKNK22.01867581
22MAPKAPK31.92750211
23CDK121.89406346
24STK241.85523634
25TTK1.82795294
26ACVR1B1.81773155
27VRK11.81243373
28BRSK21.78163177
29NME11.76059071
30TAF11.74286815
31FLT31.72211382
32PDK21.70167010
33TNIK1.69906451
34PNCK1.68277957
35TSSK61.67661414
36CDK71.67146471
37PLK11.66068043
38SRPK11.65380513
39EPHA21.64914791
40AURKB1.53240520
41DYRK31.52329234
42PLK41.48541035
43MAP4K11.48307373
44ATR1.47880933
45CDK41.44675009
46RPS6KA41.41672429
47MAP3K81.36423640
48PASK1.35683454
49STK101.34286776
50DYRK21.33605083
51MST41.30030042
52LRRK21.25224963
53TLK11.21101866
54PBK1.20401702
55TESK21.19077577
56MAP3K101.12697107
57KDR1.11468222
58BRSK11.06398564
59TGFBR11.05835885
60GRK11.04595229
61AURKA1.01954483
62PIM21.01550891
63CHEK11.00827358
64CHEK21.00729290
65CAMK1G0.96541864
66WNK30.96000286
67CDK30.93746027
68MAP3K110.92876931
69PIM10.90581601
70TYK20.88482039
71PAK40.85064267
72STK390.85012453
73MAP2K30.84915943
74PINK10.84705062
75TRIB30.84048199
76GRK60.83938976
77MAPK150.83225180
78MAP4K20.82352569
79ADRBK20.79577963
80CCNB10.78670151
81ATM0.78087936
82ERN10.77875866
83BRD40.77622645
84ZAP700.76033400
85PLK30.74862597
86INSRR0.74446099
87CDK20.74278000
88OXSR10.74143777
89MAP3K40.73951580
90MAPKAPK50.72748230
91MAPK110.72599772
92MAPK130.72502528
93JAK30.72133819
94CSNK2A20.70824614
95CSNK1G10.70128669
96RAF10.68148059
97MAP3K30.67751954
98CDK60.67434695
99PRKCG0.67174252
100CSNK1G30.67019958
101PIK3CA0.65265608
102ALK0.64351949
103MAP3K90.63086457
104TYRO30.62807832
105CAMKK20.62655106
106CAMK1D0.61730129
107CAMK10.61707006
108STK110.59735897
109TAOK10.58586828
110CDK80.56982174
111LATS10.56685555
112STK40.55778635
113CSNK2A10.53951015
114CSNK1G20.53459383
115MTOR0.51313099
116MUSK0.51242424
117FGFR20.50978671
118PRKCI0.50914053
119STK38L0.50868304
120AKT20.50645685
121TRIM280.48942092
122RPS6KA60.47607845
123IKBKB0.47056559
124PRKDC0.46453532
125MAP2K70.46001953
126MKNK10.44956255
127ERBB40.44802164
128CDK10.44202282
129BTK0.43874273
130DAPK10.42925006
131PHKG20.42178979
132PHKG10.42178979
133FGFR40.42082138
134TAOK30.41525145
135CSNK1E0.41018015
136STK30.40943182
137CSNK1A10.40151560
138TEC0.39715167
139EIF2AK20.39247975
140CASK0.39061146
141ZAK0.37350846
142AKT30.36367862
143BRAF0.32907582
144MAP3K50.32893692
145SIK10.32829004
146ABL20.32708453
147PAK10.31618723
148MAP2K60.29265168
149RPS6KA50.28334749
150MAP3K130.25810163
151TAOK20.25113291
152ILK0.25029789
153JAK20.24670522
154KIT0.23611538

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54128047
2Ribosome_Homo sapiens_hsa030103.65030432
3Mismatch repair_Homo sapiens_hsa034303.53534548
4Oxidative phosphorylation_Homo sapiens_hsa001903.25605291
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.15366730
6One carbon pool by folate_Homo sapiens_hsa006703.05391765
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67978955
8Spliceosome_Homo sapiens_hsa030402.56642931
9RNA transport_Homo sapiens_hsa030132.47959287
10Base excision repair_Homo sapiens_hsa034102.42555030
11RNA polymerase_Homo sapiens_hsa030202.42322341
12Nucleotide excision repair_Homo sapiens_hsa034202.29577994
13Pyrimidine metabolism_Homo sapiens_hsa002402.23101764
14Proteasome_Homo sapiens_hsa030502.11514440
15Homologous recombination_Homo sapiens_hsa034402.08930376
16Cell cycle_Homo sapiens_hsa041101.91478293
17Folate biosynthesis_Homo sapiens_hsa007901.89881654
18Alzheimers disease_Homo sapiens_hsa050101.76869461
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67453054
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.64660703
21Selenocompound metabolism_Homo sapiens_hsa004501.64038260
22RNA degradation_Homo sapiens_hsa030181.63428473
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63090256
24Biosynthesis of amino acids_Homo sapiens_hsa012301.62672224
25Fanconi anemia pathway_Homo sapiens_hsa034601.58024053
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.56015226
27Non-homologous end-joining_Homo sapiens_hsa034501.55624836
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.54108520
29Cardiac muscle contraction_Homo sapiens_hsa042601.51777250
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51600072
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50446053
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.48746322
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43476013
34Sulfur relay system_Homo sapiens_hsa041221.35952727
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29727196
36Phototransduction_Homo sapiens_hsa047441.27739559
37Pentose phosphate pathway_Homo sapiens_hsa000301.27004402
38p53 signaling pathway_Homo sapiens_hsa041151.26630797
39Carbon metabolism_Homo sapiens_hsa012001.25689901
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25284711
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24968019
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19450552
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17217603
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13794896
45Systemic lupus erythematosus_Homo sapiens_hsa053221.13145826
46Basal transcription factors_Homo sapiens_hsa030221.11202398
47mRNA surveillance pathway_Homo sapiens_hsa030151.03463678
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00929298
49Linoleic acid metabolism_Homo sapiens_hsa005910.96847735
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96329803
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94818556
52Fatty acid degradation_Homo sapiens_hsa000710.93049814
53Purine metabolism_Homo sapiens_hsa002300.91861772
54Nitrogen metabolism_Homo sapiens_hsa009100.91497436
55Arginine biosynthesis_Homo sapiens_hsa002200.90716567
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88660606
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84534671
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81503668
59Tryptophan metabolism_Homo sapiens_hsa003800.78349045
60Glutathione metabolism_Homo sapiens_hsa004800.75526657
61Pyruvate metabolism_Homo sapiens_hsa006200.74776093
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73409154
63Propanoate metabolism_Homo sapiens_hsa006400.71896163
64Herpes simplex infection_Homo sapiens_hsa051680.71619310
65Steroid biosynthesis_Homo sapiens_hsa001000.70997378
66Antigen processing and presentation_Homo sapiens_hsa046120.69963227
67Peroxisome_Homo sapiens_hsa041460.69826058
68Thyroid cancer_Homo sapiens_hsa052160.68832320
69Epstein-Barr virus infection_Homo sapiens_hsa051690.68786458
70Caffeine metabolism_Homo sapiens_hsa002320.68263107
71Ether lipid metabolism_Homo sapiens_hsa005650.68164190
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68064945
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67167633
74Basal cell carcinoma_Homo sapiens_hsa052170.62878924
75Lysine degradation_Homo sapiens_hsa003100.60466877
76beta-Alanine metabolism_Homo sapiens_hsa004100.59424624
77Vitamin B6 metabolism_Homo sapiens_hsa007500.58800727
78Butanoate metabolism_Homo sapiens_hsa006500.58721280
79Fructose and mannose metabolism_Homo sapiens_hsa000510.58652333
80Viral carcinogenesis_Homo sapiens_hsa052030.57857774
81Nicotine addiction_Homo sapiens_hsa050330.57029588
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56160098
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54957977
84Hedgehog signaling pathway_Homo sapiens_hsa043400.54889137
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53753847
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53220023
87Phenylalanine metabolism_Homo sapiens_hsa003600.51894135
88Protein export_Homo sapiens_hsa030600.51553988
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.50424129
90Arginine and proline metabolism_Homo sapiens_hsa003300.47787848
91Metabolic pathways_Homo sapiens_hsa011000.46828668
92Fat digestion and absorption_Homo sapiens_hsa049750.46125467
93Galactose metabolism_Homo sapiens_hsa000520.45994241
94Tyrosine metabolism_Homo sapiens_hsa003500.44825392
95Olfactory transduction_Homo sapiens_hsa047400.44573750
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44122327
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43427567
98Asthma_Homo sapiens_hsa053100.43358218
99Chemical carcinogenesis_Homo sapiens_hsa052040.43345429
100Complement and coagulation cascades_Homo sapiens_hsa046100.42379752
101Regulation of autophagy_Homo sapiens_hsa041400.38705073
102N-Glycan biosynthesis_Homo sapiens_hsa005100.37318987
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37312663
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36971513
105Oocyte meiosis_Homo sapiens_hsa041140.36199333
106Collecting duct acid secretion_Homo sapiens_hsa049660.35475594
107HTLV-I infection_Homo sapiens_hsa051660.34327106
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.34178890
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33752218
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32746368
111Retinol metabolism_Homo sapiens_hsa008300.32086773
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30239270
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29959361
114Small cell lung cancer_Homo sapiens_hsa052220.28504109
115Wnt signaling pathway_Homo sapiens_hsa043100.27391638
116Fatty acid metabolism_Homo sapiens_hsa012120.27206808
117Taste transduction_Homo sapiens_hsa047420.27139131
118Histidine metabolism_Homo sapiens_hsa003400.27075905
119Circadian rhythm_Homo sapiens_hsa047100.24982248
120Arachidonic acid metabolism_Homo sapiens_hsa005900.24536784
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.23894793
122Primary immunodeficiency_Homo sapiens_hsa053400.22891670
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.22498059
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22321056
125Bladder cancer_Homo sapiens_hsa052190.21732770
126ABC transporters_Homo sapiens_hsa020100.21543987
127Vitamin digestion and absorption_Homo sapiens_hsa049770.21078628
128Starch and sucrose metabolism_Homo sapiens_hsa005000.20916825
129Huntingtons disease_Homo sapiens_hsa050160.19982465
130Hippo signaling pathway_Homo sapiens_hsa043900.19788365
131Sulfur metabolism_Homo sapiens_hsa009200.19557215
132Apoptosis_Homo sapiens_hsa042100.19284582
133Parkinsons disease_Homo sapiens_hsa050120.18786711
134Legionellosis_Homo sapiens_hsa051340.16852661
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12633134
136Fatty acid elongation_Homo sapiens_hsa000620.11906858

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