SETD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)5.18678845
2actin-myosin filament sliding (GO:0033275)5.18678845
3locomotory exploration behavior (GO:0035641)4.80898210
4synaptic vesicle maturation (GO:0016188)4.67628507
5actin-mediated cell contraction (GO:0070252)4.66651762
6response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.33674043
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.21101072
8sarcomere organization (GO:0045214)4.11559870
9sodium ion export (GO:0071436)4.07277341
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.00137329
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.95201563
12neuronal action potential propagation (GO:0019227)3.92015817
13cellular potassium ion homeostasis (GO:0030007)3.89106943
14regulation of skeletal muscle contraction (GO:0014819)3.84579206
15actin filament-based movement (GO:0030048)3.84245443
16vocalization behavior (GO:0071625)3.83552790
17hemidesmosome assembly (GO:0031581)3.82316757
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81852449
19skeletal muscle contraction (GO:0003009)3.80499946
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.66100107
21myofibril assembly (GO:0030239)3.62858012
22response to muscle activity (GO:0014850)3.61450744
23regulation of synaptic vesicle exocytosis (GO:2000300)3.61047867
24plasma membrane repair (GO:0001778)3.60334050
25synaptic vesicle exocytosis (GO:0016079)3.59866733
26glutamate secretion (GO:0014047)3.58726296
27cell adhesion mediated by integrin (GO:0033627)3.58066610
28myoblast fusion (GO:0007520)3.56875355
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51266209
30actomyosin structure organization (GO:0031032)3.49824866
31cell-substrate junction assembly (GO:0007044)3.49006415
32cardiac myofibril assembly (GO:0055003)3.48730838
33response to inactivity (GO:0014854)3.47906201
34desmosome organization (GO:0002934)3.43309900
35potassium ion import (GO:0010107)3.41429590
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39202416
37striated muscle atrophy (GO:0014891)3.33683770
38cerebellar Purkinje cell differentiation (GO:0021702)3.32764901
39layer formation in cerebral cortex (GO:0021819)3.32060957
40regulation of glutamate receptor signaling pathway (GO:1900449)3.29216807
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.29215554
42cell communication by electrical coupling (GO:0010644)3.27617845
43syncytium formation by plasma membrane fusion (GO:0000768)3.24228287
44activation of protein kinase A activity (GO:0034199)3.23643560
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.21985580
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.20012309
47regulation of synapse structural plasticity (GO:0051823)3.19887291
48negative regulation of fatty acid transport (GO:2000192)3.18447549
49skeletal muscle adaptation (GO:0043501)3.17003914
50insulin-like growth factor receptor signaling pathway (GO:0048009)3.13104749
51negative regulation of protein localization to cell surface (GO:2000009)3.12961970
52exploration behavior (GO:0035640)3.12328664
53neurotransmitter secretion (GO:0007269)3.10983214
54regulation of synaptic vesicle transport (GO:1902803)3.09716112
55regulation of glucose import in response to insulin stimulus (GO:2001273)3.08614842
56retina vasculature morphogenesis in camera-type eye (GO:0061299)3.06803430
57kidney mesenchyme development (GO:0072074)3.05187300
58skin morphogenesis (GO:0043589)3.04250595
59regulation of ARF protein signal transduction (GO:0032012)3.03823497
60cell-substrate adherens junction assembly (GO:0007045)3.03356934
61focal adhesion assembly (GO:0048041)3.03356934
62positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.03015728
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.02758363
64regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.02053939
65collagen fibril organization (GO:0030199)2.99750608
66muscle cell fate commitment (GO:0042693)2.96217675
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96076480
68skeletal muscle fiber development (GO:0048741)2.95204139
69regulation of cell communication by electrical coupling (GO:0010649)2.94840402
70metanephric mesenchyme development (GO:0072075)2.94680430
71COPI coating of Golgi vesicle (GO:0048205)2.93922378
72Golgi transport vesicle coating (GO:0048200)2.93922378
73membrane depolarization during action potential (GO:0086010)2.93779236
74striated muscle contraction (GO:0006941)2.93525027
75carnitine shuttle (GO:0006853)2.91818063
76sarcoplasmic reticulum calcium ion transport (GO:0070296)2.91432167
77regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.91371168
78establishment of nucleus localization (GO:0040023)2.91197116
79proline transport (GO:0015824)2.91120214
80neuromuscular process controlling balance (GO:0050885)2.89957211
81regulation of long-term neuronal synaptic plasticity (GO:0048169)2.88609884
82regulation of neuronal synaptic plasticity (GO:0048168)2.87968487
83endodermal cell differentiation (GO:0035987)2.87300292
84dendritic spine morphogenesis (GO:0060997)2.86541997
85adherens junction assembly (GO:0034333)2.86368553
86cerebellar granule cell differentiation (GO:0021707)2.86242504
87muscle atrophy (GO:0014889)2.85940222
88glycine transport (GO:0015816)2.85292825
89positive regulation of myotube differentiation (GO:0010831)2.84992042
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84373702
91long-term memory (GO:0007616)2.82331963
92muscle cell cellular homeostasis (GO:0046716)2.81890489
93vesicle transport along microtubule (GO:0047496)2.81278864
94regulation of calcium ion transmembrane transport (GO:1903169)2.80905694
95regulation of calcium ion transmembrane transporter activity (GO:1901019)2.80905694
96skeletal muscle tissue development (GO:0007519)2.79716885
97iron ion import (GO:0097286)2.78295624
98glutamate receptor signaling pathway (GO:0007215)2.76819973
99muscle contraction (GO:0006936)2.76323778
100regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.76083413
101potassium ion homeostasis (GO:0055075)2.74286349
102epithelial cell-cell adhesion (GO:0090136)2.74152419
103synaptic transmission, glutamatergic (GO:0035249)2.71780377
104gamma-aminobutyric acid transport (GO:0015812)2.71061101
105vascular endothelial growth factor signaling pathway (GO:0038084)2.70649896
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.68033335
107positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.67423341
108regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.67409010
109negative regulation of cell size (GO:0045792)2.65505015
110protein localization to endosome (GO:0036010)2.65358980
111dendrite morphogenesis (GO:0048813)2.63827415
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.62943928
113myotube cell development (GO:0014904)2.62793793
114regulation of relaxation of muscle (GO:1901077)2.62130594
115sequestering of extracellular ligand from receptor (GO:0035581)2.62101037
116cell communication involved in cardiac conduction (GO:0086065)2.61042784
117COPII vesicle coating (GO:0048208)2.60494857
118regulation of transforming growth factor beta2 production (GO:0032909)2.59547808
119regulation of the force of heart contraction (GO:0002026)2.59194970
120neuron-neuron synaptic transmission (GO:0007270)2.59099275
121negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58549081
122glomerular basement membrane development (GO:0032836)2.57904293
123regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.57713322
124regulation of clathrin-mediated endocytosis (GO:2000369)2.56879204
125cellular sodium ion homeostasis (GO:0006883)2.55396102
126striated muscle adaptation (GO:0014888)2.55374212
127regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.54499432
128nerve growth factor signaling pathway (GO:0038180)2.53381606
129regulation of dendritic spine morphogenesis (GO:0061001)2.53338360
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.52924594
131macroautophagy (GO:0016236)2.52447597
132regulation of voltage-gated calcium channel activity (GO:1901385)2.52020932
133positive regulation of blood vessel endothelial cell migration (GO:0043536)2.51763698
134membrane repolarization (GO:0086009)2.51566485
135protein hydroxylation (GO:0018126)2.51064368
136negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.50519212
137syncytium formation (GO:0006949)2.50461566
138basement membrane organization (GO:0071711)2.49147122
139L-amino acid import (GO:0043092)2.49078648
140cardiac muscle contraction (GO:0060048)2.48843737
141muscle system process (GO:0003012)2.48423178
142regulation of postsynaptic membrane potential (GO:0060078)2.47135877
143cell differentiation in hindbrain (GO:0021533)2.46143205
144fatty acid transmembrane transport (GO:1902001)2.45369848
145positive regulation of potassium ion transport (GO:0043268)2.45236583
146suckling behavior (GO:0001967)2.45224450
147bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44963930
148chemosensory behavior (GO:0007635)2.44637886
149regulation of synaptic plasticity (GO:0048167)2.44560493
150long term synaptic depression (GO:0060292)2.43813635
151membrane depolarization (GO:0051899)2.43324129
152regulation of membrane repolarization (GO:0060306)2.43220718
153neuronal ion channel clustering (GO:0045161)2.42520232
154protein heterotrimerization (GO:0070208)2.41442404
155wound healing, spreading of epidermal cells (GO:0035313)2.41253078
156protein localization to synapse (GO:0035418)2.41234687
157prepulse inhibition (GO:0060134)2.39564998
158endothelial cell morphogenesis (GO:0001886)2.39517421
159regulation of ion transmembrane transporter activity (GO:0032412)2.39059495
160muscle organ development (GO:0007517)2.38932631
161neurotransmitter transport (GO:0006836)2.38501288
162protein targeting to Golgi (GO:0000042)2.38250542
163regulation of neurotransmitter secretion (GO:0046928)2.37490201
164positive regulation of membrane potential (GO:0045838)2.36770478
165negative regulation of potassium ion transmembrane transport (GO:1901380)2.36628630
166gamma-aminobutyric acid signaling pathway (GO:0007214)2.36361263
167hippo signaling (GO:0035329)2.36354739
168positive regulation of synapse maturation (GO:0090129)2.36076425
169membrane raft organization (GO:0031579)2.35720485
170myotube differentiation (GO:0014902)2.34960164
171innervation (GO:0060384)2.34784680
172chondrocyte development (GO:0002063)2.34624190
173import into cell (GO:0098657)2.34501466
174muscle structure development (GO:0061061)2.34495337
175regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34360062
176neuromuscular process controlling posture (GO:0050884)2.34172527
177neuromuscular synaptic transmission (GO:0007274)2.33950303
178retrograde transport, vesicle recycling within Golgi (GO:0000301)2.33742254
179neuromuscular junction development (GO:0007528)2.32751694
180peptidyl-proline hydroxylation (GO:0019511)2.31949462
181organelle transport along microtubule (GO:0072384)2.31872751
182hypotonic response (GO:0006971)2.31161202
183regulation of protein localization to cell surface (GO:2000008)2.30230276
184glycogen catabolic process (GO:0005980)2.29129982
185regulation of actin filament-based movement (GO:1903115)2.25168788
186stress fiber assembly (GO:0043149)2.24319861
187positive regulation of receptor recycling (GO:0001921)2.22990352
188barbed-end actin filament capping (GO:0051016)2.22639326
189endoplasmic reticulum organization (GO:0007029)2.22522225
190vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.22212932
191regulation of plasminogen activation (GO:0010755)2.22138510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.34411382
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.24857767
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.84389256
4DROSHA_22980978_ChIP-Seq_HELA_Human2.71959902
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64009185
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53279650
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46795371
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46795371
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44287156
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40525300
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.30900946
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23412365
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.21747731
14CLOCK_20551151_ChIP-Seq_293T_Human2.20934969
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20578876
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16992050
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13332424
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10669937
19* CJUN_26792858_Chip-Seq_BT549_Human2.08496585
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06177886
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05473093
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.05124858
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02336016
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01128835
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93974256
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.93663908
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.93663908
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.92489604
29* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90435498
30GBX2_23144817_ChIP-Seq_PC3_Human1.89884445
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88369519
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.88201842
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87039406
34BRD4_25478319_ChIP-Seq_HGPS_Human1.82965551
35* EZH2_27294783_Chip-Seq_ESCs_Mouse1.82703649
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82522509
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.81468453
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81131677
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.74737957
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.74737957
41AR_21572438_ChIP-Seq_LNCaP_Human1.74228686
42* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74105746
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69351407
44* EED_16625203_ChIP-ChIP_MESCs_Mouse1.68797778
45REST_21632747_ChIP-Seq_MESCs_Mouse1.65784003
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.65508466
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64750080
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62825015
49* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61274890
50KDM2B_26808549_Chip-Seq_K562_Human1.59723093
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.58786769
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.57799464
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56681623
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55088236
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54467136
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54036677
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53083274
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51146846
59ZNF263_19887448_ChIP-Seq_K562_Human1.49363428
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49235578
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.47654927
62MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46023665
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45031170
64* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41837660
65* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41630062
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41407731
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.41027595
68NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.40776390
69AR_21909140_ChIP-Seq_LNCAP_Human1.40450557
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38641198
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38464031
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.37973999
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.35468206
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35261592
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35230629
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.34406257
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33765832
78* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32548873
79TP53_16413492_ChIP-PET_HCT116_Human1.32233319
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.31472301
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30784106
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.30036387
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29583706
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29336328
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29307608
86RXR_22108803_ChIP-Seq_LS180_Human1.28818351
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.28650134
88* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27051231
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26717997
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26656141
91KDM2B_26808549_Chip-Seq_DND41_Human1.26321953
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24369165
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24267438
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.23739496
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22755021
96AR_19668381_ChIP-Seq_PC3_Human1.22037338
97TP53_18474530_ChIP-ChIP_U2OS_Human1.21582102
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21349821
99SMAD4_21799915_ChIP-Seq_A2780_Human1.21349101
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21176981
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21160453
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.20280659
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19722016
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18393411
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18227272
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.17505637
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15251261
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.14983679
109* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13883842
110AHR_22903824_ChIP-Seq_MCF-7_Human1.13718271
111* RACK7_27058665_Chip-Seq_MCF-7_Human1.12751145
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.12650905
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.11840551
114ZNF274_21170338_ChIP-Seq_K562_Hela1.11784027
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09689457
116GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08972166
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08025652
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07817058
119RING1B_27294783_Chip-Seq_NPCs_Mouse1.07749205
120PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06627160
121* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05506609
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05230085
123SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04030440
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03135478
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02884396
126STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02290313
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01800688
128P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01564447
129STAT3_23295773_ChIP-Seq_U87_Human1.01377819
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01275675
131GATA3_24758297_ChIP-Seq_MCF-7_Human1.00544730
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00104086
133* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99739756
134TP63_23658742_ChIP-Seq_EP156T_Human0.99545921
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99342026
136* SOX2_20726797_ChIP-Seq_SW620_Human0.99324501
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.99199524
138* TP53_23651856_ChIP-Seq_MEFs_Mouse0.98958984
139* ATF3_27146783_Chip-Seq_COLON_Human0.98230900
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.97018932
141AR_25329375_ChIP-Seq_VCAP_Human0.96140325
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.95805522
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.95805522
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.95529205
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.94296867
146* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93717195
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92922577
148* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92833548
149ELK3_25401928_ChIP-Seq_HUVEC_Human0.92579189
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.91818793
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.90228092
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90091200
153* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89388781
154FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89338592
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88665685
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88589026
157TCF4_23295773_ChIP-Seq_U87_Human0.88445831
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87311057
159ISL1_27105846_Chip-Seq_CPCs_Mouse0.87211491
160* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87169093
161KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86558023
162TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85933143
163PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85715522
164KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85271343
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84897793
166* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84607576
167RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84196962
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84138375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.47815512
2MP0008438_abnormal_cutaneous_collagen4.60598672
3MP0003635_abnormal_synaptic_transmissio3.12010765
4MP0004145_abnormal_muscle_electrophysio3.04577003
5MP0005275_abnormal_skin_tensile2.97679098
6MP0003950_abnormal_plasma_membrane2.94371998
7MP0004270_analgesia2.89358297
8MP0000751_myopathy2.70996728
9MP0009046_muscle_twitch2.69127631
10MP0004272_abnormal_basement_membrane2.62468575
11MP0009745_abnormal_behavioral_response2.32210267
12MP0008569_lethality_at_weaning2.30016593
13MP0003880_abnormal_central_pattern2.26800584
14MP0003566_abnormal_cell_adhesion2.26785454
15MP0005503_abnormal_tendon_morphology2.24530943
16MP0009780_abnormal_chondrocyte_physiolo2.24179548
17MP0002064_seizures2.23345586
18MP0001958_emphysema2.20523632
19MP0002063_abnormal_learning/memory/cond2.17525245
20MP0000749_muscle_degeneration1.99859540
21MP0002272_abnormal_nervous_system1.92456527
22MP0001486_abnormal_startle_reflex1.90373310
23MP0004858_abnormal_nervous_system1.90262807
24MP0003646_muscle_fatigue1.88949614
25MP0005423_abnormal_somatic_nervous1.85606399
26MP0002909_abnormal_adrenal_gland1.85326388
27MP0010368_abnormal_lymphatic_system1.82800864
28MP0002837_dystrophic_cardiac_calcinosis1.81736086
29MP0002572_abnormal_emotion/affect_behav1.81162581
30MP0004036_abnormal_muscle_relaxation1.79648895
31MP0002734_abnormal_mechanical_nocicepti1.77519937
32MP0001968_abnormal_touch/_nociception1.77230227
33MP0000747_muscle_weakness1.75397042
34MP0001501_abnormal_sleep_pattern1.72001219
35MP0003045_fibrosis1.71686765
36MP0004233_abnormal_muscle_weight1.70650766
37MP0005623_abnormal_meninges_morphology1.69395161
38MP0004130_abnormal_muscle_cell1.66367158
39MP0004084_abnormal_cardiac_muscle1.63595395
40MP0010352_gastrointestinal_tract_polyps1.61937886
41MP0002332_abnormal_exercise_endurance1.61902402
42MP0000013_abnormal_adipose_tissue1.60550022
43MP0003091_abnormal_cell_migration1.54652221
44MP0004087_abnormal_muscle_fiber1.54176608
45MP0008961_abnormal_basal_metabolism1.53446138
46MP0002067_abnormal_sensory_capabilities1.47932246
47MP0002060_abnormal_skin_morphology1.46876204
48MP0002896_abnormal_bone_mineralization1.46446717
49MP0001661_extended_life_span1.46409029
50MP0000569_abnormal_digit_pigmentation1.45886277
51MP0001440_abnormal_grooming_behavior1.45188365
52MP0000759_abnormal_skeletal_muscle1.44787520
53MP0001299_abnormal_eye_distance/1.44478958
54MP0002735_abnormal_chemical_nociception1.43701654
55MP0005257_abnormal_intraocular_pressure1.43041645
56MP0009384_cardiac_valve_regurgitation1.42354557
57MP0004811_abnormal_neuron_physiology1.39914596
58MP0003941_abnormal_skin_development1.39765586
59MP0002106_abnormal_muscle_physiology1.39702842
60MP0004885_abnormal_endolymph1.39422915
61MP0005451_abnormal_body_composition1.37260899
62MP0000767_abnormal_smooth_muscle1.37031264
63MP0002184_abnormal_innervation1.36322691
64MP0005023_abnormal_wound_healing1.36096480
65MP0004484_altered_response_of1.33794054
66MP0003879_abnormal_hair_cell1.33374854
67MP0004215_abnormal_myocardial_fiber1.32784166
68MP0005409_darkened_coat_color1.30773797
69MP0001970_abnormal_pain_threshold1.30072701
70MP0005620_abnormal_muscle_contractility1.28446449
71MP0004510_myositis1.26989743
72MP0004924_abnormal_behavior1.26818874
73MP0005386_behavior/neurological_phenoty1.26818874
74MP0002733_abnormal_thermal_nociception1.26322647
75MP0005369_muscle_phenotype1.26028465
76MP0003828_pulmonary_edema1.25625089
77MP0002822_catalepsy1.25260014
78MP0003633_abnormal_nervous_system1.19971597
79MP0003329_amyloid_beta_deposits1.19565602
80MP0003300_gastrointestinal_ulcer1.19241267
81MP0000003_abnormal_adipose_tissue1.18419488
82MP0000955_abnormal_spinal_cord1.17854178
83MP0000733_abnormal_muscle_development1.17140110
84MP0002557_abnormal_social/conspecific_i1.15196279
85MP0004185_abnormal_adipocyte_glucose1.14773297
86MP0002269_muscular_atrophy1.14123886
87MP0002877_abnormal_melanocyte_morpholog1.11396625
88MP0003191_abnormal_cellular_cholesterol1.11011976
89MP0003283_abnormal_digestive_organ1.10284162
90MP0001542_abnormal_bone_strength1.10106562
91MP0000762_abnormal_tongue_morphology1.10093660
92MP0002971_abnormal_brown_adipose1.09006556
93MP0002736_abnormal_nociception_after1.08301818
94MP0001879_abnormal_lymphatic_vessel1.06983065
95MP0002066_abnormal_motor_capabilities/c1.06891673
96MP0004085_abnormal_heartbeat1.06804221
97MP0005670_abnormal_white_adipose1.04127037
98MP0003705_abnormal_hypodermis_morpholog1.02635123
99MP0009053_abnormal_anal_canal1.02137664
100MP0000467_abnormal_esophagus_morphology1.01224815
101MP0000534_abnormal_ureter_morphology0.98824248
102MP0000920_abnormal_myelination0.98820940
103MP0002108_abnormal_muscle_morphology0.97110777
104MP0002972_abnormal_cardiac_muscle0.96090539
105MP0009250_abnormal_appendicular_skeleto0.94183591
106MP0010234_abnormal_vibrissa_follicle0.93611280
107MP0002882_abnormal_neuron_morphology0.92975549
108MP0003631_nervous_system_phenotype0.92826541
109MP0003137_abnormal_impulse_conducting0.90985576
110MP0003690_abnormal_glial_cell0.90699020
111MP0003868_abnormal_feces_composition0.90462710
112MP0005645_abnormal_hypothalamus_physiol0.89133946
113MP0005595_abnormal_vascular_smooth0.88738535
114MP0002009_preneoplasia0.87328726
115MP0004134_abnormal_chest_morphology0.86724991
116MP0005666_abnormal_adipose_tissue0.86156401
117MP0005167_abnormal_blood-brain_barrier0.85223575
118MP0005375_adipose_tissue_phenotype0.84566044
119MP0000778_abnormal_nervous_system0.83912404
120MP0008775_abnormal_heart_ventricle0.83900450
121MP0001485_abnormal_pinna_reflex0.83754647
122MP0005076_abnormal_cell_differentiation0.83113519
123MP0004742_abnormal_vestibular_system0.82688595
124MP0002089_abnormal_postnatal_growth/wei0.82498749
125MP0005508_abnormal_skeleton_morphology0.82013937
126MP0000750_abnormal_muscle_regeneration0.81238795
127MP0005330_cardiomyopathy0.81151500
128MP0005377_hearing/vestibular/ear_phenot0.80122131
129MP0003878_abnormal_ear_physiology0.80122131
130MP0005165_increased_susceptibility_to0.79071005
131MP0002796_impaired_skin_barrier0.78960103
132MP0005385_cardiovascular_system_phenoty0.78553922
133MP0001544_abnormal_cardiovascular_syste0.78553922
134MP0002127_abnormal_cardiovascular_syste0.78336659
135MP0002168_other_aberrant_phenotype0.77337209
136MP0003634_abnormal_glial_cell0.76755719
137MP0006138_congestive_heart_failure0.76381211
138MP0002128_abnormal_blood_circulation0.76284042
139MP0003075_altered_response_to0.75971102
140MP0001348_abnormal_lacrimal_gland0.75030798
141MP0002152_abnormal_brain_morphology0.73961786
142MP0003453_abnormal_keratinocyte_physiol0.72427846
143MP0010630_abnormal_cardiac_muscle0.72161113
144MP0004043_abnormal_pH_regulation0.71406016
145MP0005187_abnormal_penis_morphology0.69846431
146MP0003279_aneurysm0.69522948
147MP0001502_abnormal_circadian_rhythm0.69486367
148* MP0008874_decreased_physiological_sensi0.68900626
149MP0003632_abnormal_nervous_system0.68845245
150MP0000462_abnormal_digestive_system0.66260803
151MP0003959_abnormal_lean_body0.66127498
152MP0003385_abnormal_body_wall0.63772082
153MP0000627_abnormal_mammary_gland0.62834462
154MP0003221_abnormal_cardiomyocyte_apopto0.62642473
155MP0002295_abnormal_pulmonary_circulatio0.61816234
156MP0000266_abnormal_heart_morphology0.61814530
157MP0000537_abnormal_urethra_morphology0.61262686
158MP0010678_abnormal_skin_adnexa0.58532259
159MP0001243_abnormal_dermal_layer0.57281579
160MP0000579_abnormal_nail_morphology0.56973745

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.49896055
2Focal motor seizures (HP:0011153)4.18397200
3Premature rupture of membranes (HP:0001788)4.06894064
4Action tremor (HP:0002345)3.86661134
5Exercise-induced myalgia (HP:0003738)3.82765689
6Myokymia (HP:0002411)3.64268382
7Focal seizures (HP:0007359)3.57465301
8Visual hallucinations (HP:0002367)3.51117130
9Aortic aneurysm (HP:0004942)3.42694680
10Difficulty running (HP:0009046)3.41503219
11Distal lower limb muscle weakness (HP:0009053)3.27913861
12Ulnar deviation of the wrist (HP:0003049)3.27782323
13Spinal rigidity (HP:0003306)3.27557901
14Progressive cerebellar ataxia (HP:0002073)3.26135059
15Exercise-induced muscle cramps (HP:0003710)3.22027518
16Aortic dissection (HP:0002647)3.21572338
17Vascular tortuosity (HP:0004948)3.17437224
18Dysmetric saccades (HP:0000641)3.15791918
19Hyporeflexia of lower limbs (HP:0002600)3.14232434
20Asymmetric septal hypertrophy (HP:0001670)3.13770009
21Arterial tortuosity (HP:0005116)3.13701059
22Neck muscle weakness (HP:0000467)3.00888904
23Type 1 muscle fiber predominance (HP:0003803)2.81477853
24Muscle hypertrophy of the lower extremities (HP:0008968)2.79191973
25Calcaneovalgus deformity (HP:0001848)2.77693192
26Popliteal pterygium (HP:0009756)2.74274672
27Atonic seizures (HP:0010819)2.73929974
28Genetic anticipation (HP:0003743)2.66931647
29Muscle fiber inclusion bodies (HP:0100299)2.66380132
30Calf muscle hypertrophy (HP:0008981)2.63936057
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.63112217
32Increased variability in muscle fiber diameter (HP:0003557)2.62947447
33Myotonia (HP:0002486)2.62521309
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.60324074
35Bundle branch block (HP:0011710)2.55086538
36Papilledema (HP:0001085)2.54981575
37Atrophic scars (HP:0001075)2.54496260
38Sudden death (HP:0001699)2.53571847
39Deformed tarsal bones (HP:0008119)2.52985540
40Hemiplegia (HP:0002301)2.49611199
41Gaze-evoked nystagmus (HP:0000640)2.46914863
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.46912752
43Osteolytic defects of the hand bones (HP:0009699)2.46912752
44Muscle fiber splitting (HP:0003555)2.43061517
45Ventricular fibrillation (HP:0001663)2.42117323
46Dysdiadochokinesis (HP:0002075)2.41754489
47Overgrowth (HP:0001548)2.41528029
48Round ear (HP:0100830)2.39894955
49Abnormality of skeletal muscle fiber size (HP:0012084)2.39656198
50Abnormality of the calf musculature (HP:0001430)2.39477328
51Broad-based gait (HP:0002136)2.38622916
52Absence seizures (HP:0002121)2.37438676
53Truncal ataxia (HP:0002078)2.36243282
54Malignant hyperthermia (HP:0002047)2.33895387
55Scanning speech (HP:0002168)2.33847582
56Fragile skin (HP:0001030)2.32296395
57Macroorchidism (HP:0000053)2.32050095
58Gowers sign (HP:0003391)2.31706503
59Urinary urgency (HP:0000012)2.31647492
60Ankle contracture (HP:0006466)2.29465831
61Broad metatarsal (HP:0001783)2.28725389
62Depression (HP:0000716)2.28213073
63Scapular winging (HP:0003691)2.27728892
64Increased connective tissue (HP:0009025)2.27007539
65Lower limb amyotrophy (HP:0007210)2.26613676
66EMG: myopathic abnormalities (HP:0003458)2.26018853
67Dysmetria (HP:0001310)2.25931751
68Distal arthrogryposis (HP:0005684)2.25899742
69Urinary bladder sphincter dysfunction (HP:0002839)2.25871505
70Fatigable weakness (HP:0003473)2.25130117
71Abnormality of the neuromuscular junction (HP:0003398)2.25130117
72Febrile seizures (HP:0002373)2.23006539
73Impaired vibration sensation in the lower limbs (HP:0002166)2.22386184
74Mitral stenosis (HP:0001718)2.21806155
75Shallow orbits (HP:0000586)2.20594567
76Supranuclear gaze palsy (HP:0000605)2.20472433
77Slender build (HP:0001533)2.19817024
78Impaired smooth pursuit (HP:0007772)2.19730614
79Poor eye contact (HP:0000817)2.19606270
80Wormian bones (HP:0002645)2.18602206
81Right ventricular cardiomyopathy (HP:0011663)2.18493074
82Soft skin (HP:0000977)2.18392555
83Intention tremor (HP:0002080)2.18080028
84Nemaline bodies (HP:0003798)2.17830867
85Abnormal social behavior (HP:0012433)2.17580743
86Impaired social interactions (HP:0000735)2.17580743
87Ankle clonus (HP:0011448)2.14800576
88Termporal pattern (HP:0011008)2.14342407
89Insidious onset (HP:0003587)2.14342407
90Epileptic encephalopathy (HP:0200134)2.13937420
91Subaortic stenosis (HP:0001682)2.13140725
92Abnormality of the left ventricular outflow tract (HP:0011103)2.13140725
93Absent phalangeal crease (HP:0006109)2.12868523
94Lipoatrophy (HP:0100578)2.10669075
95Bladder diverticulum (HP:0000015)2.10155256
96Generalized tonic-clonic seizures (HP:0002069)2.08886815
97Bulbar palsy (HP:0001283)2.08041285
98Ventricular tachycardia (HP:0004756)2.07540275
99Vertebral compression fractures (HP:0002953)2.06398415
100Cerebral aneurysm (HP:0004944)2.05728549
101Prolonged QT interval (HP:0001657)2.05022385
102Abnormality of the calcaneus (HP:0008364)2.03649248
103Follicular hyperkeratosis (HP:0007502)2.00968399
104Pointed chin (HP:0000307)2.00104186
105Dialeptic seizures (HP:0011146)2.00060110
106Spondylolisthesis (HP:0003302)1.99547100
107Rapidly progressive (HP:0003678)1.98181733
108Fetal akinesia sequence (HP:0001989)1.97143574
109Postural instability (HP:0002172)1.96981594
110Diplopia (HP:0000651)1.95628570
111Abnormality of binocular vision (HP:0011514)1.95628570
112Rhabdomyolysis (HP:0003201)1.95346022
113Abnormal atrioventricular conduction (HP:0005150)1.95167001
114Cardiovascular calcification (HP:0011915)1.94922429
115Back pain (HP:0003418)1.94911331
116Metatarsus adductus (HP:0001840)1.93988026
117Pterygium (HP:0001059)1.93917524
118Mitral valve prolapse (HP:0001634)1.93706848
119Short nail (HP:0001799)1.92613513
120Frequent falls (HP:0002359)1.92437805
121Annular pancreas (HP:0001734)1.91777408
122Abnormality of ocular smooth pursuit (HP:0000617)1.90066045
123Achilles tendon contracture (HP:0001771)1.89551267
124Hyperacusis (HP:0010780)1.86696159
125Generalized amyotrophy (HP:0003700)1.86301227
126Difficulty climbing stairs (HP:0003551)1.86027646
127Limb-girdle muscle atrophy (HP:0003797)1.85750429
128Areflexia of lower limbs (HP:0002522)1.85250028
129Cervical subluxation (HP:0003308)1.85096705
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84996822
131Hip contracture (HP:0003273)1.84232009
132Ankyloglossia (HP:0010296)1.84139064
133Vertebral arch anomaly (HP:0008438)1.84013572
134Atrioventricular block (HP:0001678)1.83590278
135Distal lower limb amyotrophy (HP:0008944)1.83588913
136Megalencephaly (HP:0001355)1.83487151
137Aortic regurgitation (HP:0001659)1.83457405
138Muscle stiffness (HP:0003552)1.83188728
139Abnormal finger flexion creases (HP:0006143)1.82628016
140Aneurysm (HP:0002617)1.82515197
141Blue sclerae (HP:0000592)1.81958121
142Postural tremor (HP:0002174)1.81011014
143Reduced subcutaneous adipose tissue (HP:0003758)1.80984753
144Proximal amyotrophy (HP:0007126)1.79201188
145Atrial fibrillation (HP:0005110)1.77135181
146Myopathic facies (HP:0002058)1.76924256
147Heart block (HP:0012722)1.76921640
148Mildly elevated creatine phosphokinase (HP:0008180)1.74408858
149Limited hip movement (HP:0008800)1.74401685
150Elbow flexion contracture (HP:0002987)1.74002451
151EMG: neuropathic changes (HP:0003445)1.73767638
152Insomnia (HP:0100785)1.73465260
153Primary atrial arrhythmia (HP:0001692)1.72803856
154Breech presentation (HP:0001623)1.72246000
155Stereotypic behavior (HP:0000733)1.71447583
156Resting tremor (HP:0002322)1.71303609
157Limb-girdle muscle weakness (HP:0003325)1.70918230
158Unilateral renal agenesis (HP:0000122)1.70084556
159Upper limb amyotrophy (HP:0009129)1.69627801
160Distal upper limb amyotrophy (HP:0007149)1.69627801
161Anxiety (HP:0000739)1.69177401
162Mitral regurgitation (HP:0001653)1.68370927
163Obstructive sleep apnea (HP:0002870)1.67858962
164Spinal canal stenosis (HP:0003416)1.67484953
165Abnormal EKG (HP:0003115)1.66980043
166Myoglobinuria (HP:0002913)1.66222334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.11746979
2TRIB32.59201656
3MAP3K92.46838528
4TTN2.43372989
5MUSK2.32787468
6MST1R2.29426347
7PIK3CG2.24390950
8NEK92.13280120
9RIPK12.10188636
10SIK22.09337266
11MYLK2.06391357
12PAK62.04912569
13EPHA42.02381309
14PHKG12.01789104
15PHKG22.01789104
16PRKD32.01438323
17TRPM71.99787132
18CAMKK11.97725345
19MAP3K41.89593304
20DMPK1.87512105
21SIK11.77497437
22WNK11.74812735
23MET1.73688105
24NTRK11.70789144
25KSR21.69909127
26EPHA21.68001327
27MINK11.67483076
28CAMKK21.67227305
29CAMK1G1.66240907
30STK381.65013720
31MAP2K41.57045233
32DAPK21.53687477
33LMTK21.50347727
34MAP3K71.48042370
35AKT31.46562131
36MAPKAPK31.45721890
37PRKCH1.40095679
38MAP3K21.39141202
39LIMK11.34276144
40RET1.32980436
41NTRK21.31390149
42TGFBR21.30301165
43PDGFRA1.29766111
44CDK121.26368369
45MOS1.24347245
46PAK21.24031295
47EEF2K1.23880088
48ALK1.23037287
49SGK31.21761172
50PKN21.21516549
51TYRO31.21333781
52MTOR1.15274989
53OBSCN1.10408255
54MARK21.09421851
55CDK51.09278814
56CAMK11.07531800
57IRAK31.07464199
58TAOK11.06294754
59RIPK41.03846384
60STK111.01969836
61SIK31.00978582
62CAMK1D0.99026794
63EPHB10.93066137
64DDR20.91488344
65PAK30.91135801
66PRPF4B0.90787023
67MAP2K10.90167452
68STK38L0.89490144
69SGK20.89438588
70PDK10.88674858
71FGFR20.88108953
72PAK40.87592600
73SGK2230.86368034
74SGK4940.86368034
75PRKAA20.85927423
76ERBB40.84807002
77PDPK10.84638579
78PTK60.83273335
79LATS20.82767864
80BMX0.80833292
81UHMK10.80120180
82ERBB30.79915070
83CAMK2G0.79642476
84CDC42BPA0.78587125
85MAP3K60.77698203
86SGK10.77331525
87KSR10.75194807
88PDGFRB0.74992124
89TESK10.74661028
90MARK10.73271460
91PNCK0.72888389
92SCYL20.72804507
93EPHB20.72427355
94CAMK40.71958251
95MAP2K70.71759812
96STK390.69279784
97MAP3K10.69115077
98ERN10.69027676
99LATS10.67895296
100MAP2K30.67512836
101FES0.66603361
102PTK2B0.66053520
103MAP3K130.64668824
104ROCK20.64305518
105FER0.64274754
106RPS6KA20.62901979
107FGFR30.62640158
108MELK0.62639314
109PRKD10.61303632
110PTK20.60937967
111PRKAA10.59592588
112ARAF0.59415136
113AKT20.59092696
114HIPK20.58918911
115SMG10.58905253
116RPS6KB20.57526442
117CDK190.56262011
118RPS6KA30.54681154
119CAMK2A0.54318125
120CAMK2B0.54301118
121FYN0.54158767
122ABL20.53227409
123JAK10.53093691
124MAPK120.52985449
125MAP3K120.52920456
126NEK60.52883236
127FGFR10.52754242
128ILK0.52705403
129PIK3CA0.51578215
130MAPK70.51459218
131ICK0.51170310
132CAMK2D0.49189935
133GRK50.49071202
134MAP3K30.48753171
135CDK80.48474465
136MAPKAPK50.48364211
137TNK20.48109295
138MAPK110.47496380
139PRKCG0.47119116
140MAPK100.46990573
141ROCK10.46768052
142PLK20.46722841
143CDK150.46427735
144PRKD20.46069861
145CDK140.45569447
146PBK0.41127386
147GSK3A0.39709996
148CDK60.39612596
149RPS6KB10.36682428
150STK30.33440656

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.14439088
2Circadian entrainment_Homo sapiens_hsa047132.03639169
3Nicotine addiction_Homo sapiens_hsa050332.02441204
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94087441
5Gastric acid secretion_Homo sapiens_hsa049711.90529427
6Glutamatergic synapse_Homo sapiens_hsa047241.87874206
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86130114
8Synaptic vesicle cycle_Homo sapiens_hsa047211.84838795
9Salivary secretion_Homo sapiens_hsa049701.81772232
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78253145
11Olfactory transduction_Homo sapiens_hsa047401.78098255
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77206056
13GABAergic synapse_Homo sapiens_hsa047271.75779674
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69551474
15Insulin secretion_Homo sapiens_hsa049111.68266091
16Morphine addiction_Homo sapiens_hsa050321.67400906
17Amphetamine addiction_Homo sapiens_hsa050311.65608147
18Oxytocin signaling pathway_Homo sapiens_hsa049211.62721579
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60181736
20Dilated cardiomyopathy_Homo sapiens_hsa054141.58243015
21Cholinergic synapse_Homo sapiens_hsa047251.57479529
22Dopaminergic synapse_Homo sapiens_hsa047281.57211208
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53554758
24Long-term depression_Homo sapiens_hsa047301.52534748
25Type II diabetes mellitus_Homo sapiens_hsa049301.50857675
26Renin secretion_Homo sapiens_hsa049241.46227443
27Calcium signaling pathway_Homo sapiens_hsa040201.40169210
28GnRH signaling pathway_Homo sapiens_hsa049121.39329664
29Phenylalanine metabolism_Homo sapiens_hsa003601.38238281
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35233246
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33194999
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30046308
33Glioma_Homo sapiens_hsa052141.28741835
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27941049
35Nitrogen metabolism_Homo sapiens_hsa009101.26518326
36Estrogen signaling pathway_Homo sapiens_hsa049151.26027172
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23736817
38Dorso-ventral axis formation_Homo sapiens_hsa043201.22140221
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20712730
40cAMP signaling pathway_Homo sapiens_hsa040241.19141460
41Taste transduction_Homo sapiens_hsa047421.18733084
42Arginine biosynthesis_Homo sapiens_hsa002201.17806364
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17425107
44Gap junction_Homo sapiens_hsa045401.17011385
45Small cell lung cancer_Homo sapiens_hsa052221.15930573
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13936200
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13727075
48Cocaine addiction_Homo sapiens_hsa050301.13350705
49Histidine metabolism_Homo sapiens_hsa003401.13020296
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11959917
51Bladder cancer_Homo sapiens_hsa052191.09098026
52ErbB signaling pathway_Homo sapiens_hsa040121.07828500
53mTOR signaling pathway_Homo sapiens_hsa041501.05081670
54Arginine and proline metabolism_Homo sapiens_hsa003301.04232940
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.02404468
56Melanogenesis_Homo sapiens_hsa049161.02211957
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.01130754
58Serotonergic synapse_Homo sapiens_hsa047261.00812432
59Pancreatic secretion_Homo sapiens_hsa049721.00410231
60Bile secretion_Homo sapiens_hsa049760.99628767
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99135749
62Thyroid cancer_Homo sapiens_hsa052160.96939901
63Fatty acid degradation_Homo sapiens_hsa000710.96566596
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.96380175
65Axon guidance_Homo sapiens_hsa043600.92401509
66VEGF signaling pathway_Homo sapiens_hsa043700.91806873
67Renal cell carcinoma_Homo sapiens_hsa052110.91781632
68Focal adhesion_Homo sapiens_hsa045100.91064887
69PPAR signaling pathway_Homo sapiens_hsa033200.90774307
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90629157
71MAPK signaling pathway_Homo sapiens_hsa040100.90134155
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89595468
73Thyroid hormone synthesis_Homo sapiens_hsa049180.89435196
74Complement and coagulation cascades_Homo sapiens_hsa046100.88875456
75Prion diseases_Homo sapiens_hsa050200.88604269
76TGF-beta signaling pathway_Homo sapiens_hsa043500.87946274
77Glucagon signaling pathway_Homo sapiens_hsa049220.86634111
78Cardiac muscle contraction_Homo sapiens_hsa042600.86307192
79Melanoma_Homo sapiens_hsa052180.86209048
80Pentose phosphate pathway_Homo sapiens_hsa000300.85292587
81Hippo signaling pathway_Homo sapiens_hsa043900.85004783
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84988129
83Pyruvate metabolism_Homo sapiens_hsa006200.84933566
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.83921184
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83149325
86Proteoglycans in cancer_Homo sapiens_hsa052050.83086511
87Insulin signaling pathway_Homo sapiens_hsa049100.81989581
88Prostate cancer_Homo sapiens_hsa052150.81877283
89Protein digestion and absorption_Homo sapiens_hsa049740.81258781
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81194614
91Choline metabolism in cancer_Homo sapiens_hsa052310.80675012
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80220490
93Platelet activation_Homo sapiens_hsa046110.80071022
94Rap1 signaling pathway_Homo sapiens_hsa040150.79555757
95Non-small cell lung cancer_Homo sapiens_hsa052230.78436882
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78055568
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77376412
98beta-Alanine metabolism_Homo sapiens_hsa004100.76841648
99Circadian rhythm_Homo sapiens_hsa047100.76767952
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76591875
101MicroRNAs in cancer_Homo sapiens_hsa052060.75353024
102Fatty acid biosynthesis_Homo sapiens_hsa000610.75221751
103Endometrial cancer_Homo sapiens_hsa052130.73913729
104Tyrosine metabolism_Homo sapiens_hsa003500.73468005
105Caffeine metabolism_Homo sapiens_hsa002320.71460882
106Vitamin B6 metabolism_Homo sapiens_hsa007500.70996804
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70398058
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70284118
109Insulin resistance_Homo sapiens_hsa049310.70154659
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70027851
111Chronic myeloid leukemia_Homo sapiens_hsa052200.69291650
112Inositol phosphate metabolism_Homo sapiens_hsa005620.68739074
113Endocytosis_Homo sapiens_hsa041440.68245936
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66880283
115* Lysine degradation_Homo sapiens_hsa003100.65643474
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.64370221
117Ras signaling pathway_Homo sapiens_hsa040140.64244242
118Carbon metabolism_Homo sapiens_hsa012000.63787027
119Tryptophan metabolism_Homo sapiens_hsa003800.63169582
120Tight junction_Homo sapiens_hsa045300.63062309
121Amoebiasis_Homo sapiens_hsa051460.62514568
122ABC transporters_Homo sapiens_hsa020100.62458273
123* FoxO signaling pathway_Homo sapiens_hsa040680.62307316
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.60870304
125Wnt signaling pathway_Homo sapiens_hsa043100.60354643
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.59905606
127Starch and sucrose metabolism_Homo sapiens_hsa005000.59592281
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59575268
129Oocyte meiosis_Homo sapiens_hsa041140.57913646
130AMPK signaling pathway_Homo sapiens_hsa041520.57413744
131Prolactin signaling pathway_Homo sapiens_hsa049170.56471790
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.56418139
133ECM-receptor interaction_Homo sapiens_hsa045120.56013906
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54971498
135Adherens junction_Homo sapiens_hsa045200.53956147
136Chemokine signaling pathway_Homo sapiens_hsa040620.51511874
137Pathways in cancer_Homo sapiens_hsa052000.51504880
138T cell receptor signaling pathway_Homo sapiens_hsa046600.51483495
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51278354
140HIF-1 signaling pathway_Homo sapiens_hsa040660.49878458
141Sulfur metabolism_Homo sapiens_hsa009200.49139369
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.48498374
143Pancreatic cancer_Homo sapiens_hsa052120.48085560

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