SETD8P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cysteine metabolic process (GO:0006534)7.35383177
2response to xenobiotic stimulus (GO:0009410)7.23353553
3viral mRNA export from host cell nucleus (GO:0046784)6.64227491
4positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.97041637
5positive regulation of T cell apoptotic process (GO:0070234)5.73534870
6innate immune response in mucosa (GO:0002227)5.63181835
7negative regulation of T cell differentiation in thymus (GO:0033085)5.50723811
8proteasome assembly (GO:0043248)5.18586432
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.15076634
10cellular response to interleukin-15 (GO:0071350)5.14072676
11positive regulation of uterine smooth muscle contraction (GO:0070474)4.81999686
12positive regulation of lymphocyte apoptotic process (GO:0070230)4.76786078
13regulation of interferon-gamma biosynthetic process (GO:0045072)4.67936076
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66950220
15L-ascorbic acid metabolic process (GO:0019852)4.60493333
16antigen processing and presentation of endogenous antigen (GO:0019883)4.58720576
17mucosal immune response (GO:0002385)4.55811665
18chromatin assembly (GO:0031497)4.52116823
19antibacterial humoral response (GO:0019731)4.49825182
20T-helper 1 type immune response (GO:0042088)4.44057838
21hyperosmotic salinity response (GO:0042538)4.42677329
22CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.38983409
23regulation of protein polyubiquitination (GO:1902914)4.37017148
24regulation of mitochondrial depolarization (GO:0051900)4.12589818
25response to nitrosative stress (GO:0051409)4.11688080
26antimicrobial humoral response (GO:0019730)4.07780654
27regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.07620894
28organ or tissue specific immune response (GO:0002251)4.03150243
29copper ion homeostasis (GO:0055070)4.00815886
30response to interleukin-15 (GO:0070672)3.99908298
31activation of MAPKKK activity (GO:0000185)3.78775903
32glutathione biosynthetic process (GO:0006750)3.75622923
33B cell proliferation (GO:0042100)3.72186704
34regulation of thymocyte apoptotic process (GO:0070243)3.71048586
35regulation of T cell differentiation in thymus (GO:0033081)3.68976836
36immunoglobulin mediated immune response (GO:0016064)3.65412632
37DNA deamination (GO:0045006)3.65315339
38positive regulation of humoral immune response (GO:0002922)3.61842295
39T cell lineage commitment (GO:0002360)3.60698515
40positive regulation of prostaglandin secretion (GO:0032308)3.60420913
41nucleosome assembly (GO:0006334)3.54178984
42tongue development (GO:0043586)3.53341056
43DNA replication-dependent nucleosome organization (GO:0034723)3.53156644
44DNA replication-dependent nucleosome assembly (GO:0006335)3.53156644
45regulation of uterine smooth muscle contraction (GO:0070472)3.49146726
46intra-S DNA damage checkpoint (GO:0031573)3.45237421
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39372440
48regulation of isotype switching to IgG isotypes (GO:0048302)3.37648312
49S-adenosylmethionine metabolic process (GO:0046500)3.36021219
50negative regulation of B cell apoptotic process (GO:0002903)3.35988113
51nonribosomal peptide biosynthetic process (GO:0019184)3.32538540
52response to arsenic-containing substance (GO:0046685)3.25575129
53B cell mediated immunity (GO:0019724)3.25294036
54regulation of immunoglobulin secretion (GO:0051023)3.24302012
55myeloid dendritic cell differentiation (GO:0043011)3.24074135
56positive regulation of T cell differentiation in thymus (GO:0033089)3.16838075
57protein-DNA complex assembly (GO:0065004)3.14268335
58regulation of gamma-delta T cell differentiation (GO:0045586)3.12152256
59positive regulation of interleukin-12 production (GO:0032735)3.10749999
60endothelial cell chemotaxis (GO:0035767)3.08435874
61regulation of chromatin binding (GO:0035561)3.04869053
62positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.04798272
63somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.02974294
64somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.02974294
65isotype switching (GO:0045190)3.02974294
66positive regulation of leukocyte apoptotic process (GO:2000108)3.00941368
67positive regulation of mitotic sister chromatid separation (GO:1901970)3.00639438
68positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00639438
69positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00639438
70regulation of interleukin-12 biosynthetic process (GO:0045075)2.98988193
71cellular response to interferon-beta (GO:0035458)2.95976432
72regulation of prostaglandin secretion (GO:0032306)2.95748120
73nucleosome organization (GO:0034728)2.95062358
74positive regulation of alpha-beta T cell proliferation (GO:0046641)2.94785095
75regulation of gamma-delta T cell activation (GO:0046643)2.93323325
76regulation of T cell mediated cytotoxicity (GO:0001914)2.92925223
77hyperosmotic response (GO:0006972)2.92504736
78NIK/NF-kappaB signaling (GO:0038061)2.92368009
79regulation of translational termination (GO:0006449)2.90656694
80positive regulation of interferon-gamma production (GO:0032729)2.88767874
81B cell receptor signaling pathway (GO:0050853)2.86169835
82peptidyl-arginine omega-N-methylation (GO:0035247)2.78960020
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71483682
84myeloid dendritic cell activation (GO:0001773)2.70999328
85regulation of interleukin-12 production (GO:0032655)2.70228532
86positive regulation of macrophage cytokine production (GO:0060907)2.69467167
87protein-DNA complex subunit organization (GO:0071824)2.69271490
88negative regulation of immunoglobulin mediated immune response (GO:0002890)2.68447975
89negative regulation of B cell mediated immunity (GO:0002713)2.68447975
90cytidine deamination (GO:0009972)2.64769887
91cytidine metabolic process (GO:0046087)2.64769887
92cytidine catabolic process (GO:0006216)2.64769887
93positive regulation of protein sumoylation (GO:0033235)2.62869338
94cellular hyperosmotic response (GO:0071474)2.59373614
95positive regulation of cell killing (GO:0031343)2.59348301
96DNA strand elongation involved in DNA replication (GO:0006271)2.59019539
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57645801
98response to interferon-beta (GO:0035456)2.57091604
99telomere maintenance via semi-conservative replication (GO:0032201)2.56247879
100T cell migration (GO:0072678)2.54455082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.69595565
2E2F7_22180533_ChIP-Seq_HELA_Human3.53053961
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.15081776
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10731408
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82692368
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74730471
7MYC_22102868_ChIP-Seq_BL_Human2.57645440
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.56075049
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.55879437
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.34152107
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32444311
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31973462
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.28304939
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17468108
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.11907981
16VDR_21846776_ChIP-Seq_THP-1_Human2.07514931
17VDR_23849224_ChIP-Seq_CD4+_Human2.03773663
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01017375
19SOX2_16153702_ChIP-ChIP_HESCs_Human2.00552693
20MAF_26560356_Chip-Seq_TH1_Human1.96815490
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.94872249
22HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.94820484
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94418125
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93764690
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90645101
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87472321
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85307725
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.81247524
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.81232715
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.81105519
31XRN2_22483619_ChIP-Seq_HELA_Human1.80444398
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77168907
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76354856
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74457449
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72337310
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.65114923
37DCP1A_22483619_ChIP-Seq_HELA_Human1.65049832
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64670100
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64359169
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63729679
41CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.61638174
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60967504
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58810763
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56636508
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54568606
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53838809
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53732211
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52395114
49ZNF263_19887448_ChIP-Seq_K562_Human1.51584746
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50128921
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48371939
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42365040
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40493538
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40154029
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.38080567
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34509527
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.32552715
58FOXP3_21729870_ChIP-Seq_TREG_Human1.30485564
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29055721
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.27183658
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26401083
62IRF1_19129219_ChIP-ChIP_H3396_Human1.25395118
63TTF2_22483619_ChIP-Seq_HELA_Human1.25073835
64CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.21348219
65MYC_18940864_ChIP-ChIP_HL60_Human1.21177649
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20866472
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18329373
68ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18004014
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16882880
70MYB_26560356_Chip-Seq_TH1_Human1.16242882
71CIITA_25753668_ChIP-Seq_RAJI_Human1.15614312
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15515865
73MAF_26560356_Chip-Seq_TH2_Human1.15136987
74ETS1_22383799_ChIP-Seq_G1ME_Mouse1.13950057
75UTX_26944678_Chip-Seq_JUKART_Human1.12828343
76SPI1_20517297_ChIP-Seq_HL60_Human1.12220032
77LXR_22292898_ChIP-Seq_THP-1_Human1.11614432
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09026416
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07649238
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.06463299
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05960021
82MYB_26560356_Chip-Seq_TH2_Human1.04333977
83VDR_24763502_ChIP-Seq_THP-1_Human1.03210093
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02680075
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01199403
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00955376
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00428089
88GABP_19822575_ChIP-Seq_HepG2_Human0.98974604
89NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95406889
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94210368
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93787297
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93633927
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93567316
94PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93472226
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92498780
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91876524
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90675736
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90106599
99TP63_17297297_ChIP-ChIP_HaCaT_Human0.90004941
100BCOR_27268052_Chip-Seq_Bcells_Human0.89855053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol6.16212376
2MP0000685_abnormal_immune_system5.11873253
3MP0005671_abnormal_response_to3.92153774
4MP0003806_abnormal_nucleotide_metabolis3.89738726
5MP0003763_abnormal_thymus_physiology3.51530592
6MP0005623_abnormal_meninges_morphology3.32096080
7MP0001835_abnormal_antigen_presentation3.27302397
8MP0005387_immune_system_phenotype3.06115160
9MP0001790_abnormal_immune_system3.06115160
10MP0001800_abnormal_humoral_immune2.93572379
11MP0005423_abnormal_somatic_nervous2.75252150
12MP0002254_reproductive_system_inflammat2.68086019
13MP0000750_abnormal_muscle_regeneration2.67866709
14MP0005000_abnormal_immune_tolerance2.55404379
15MP0003436_decreased_susceptibility_to2.46491405
16MP0001348_abnormal_lacrimal_gland2.26711418
17MP0008057_abnormal_DNA_replication2.23197163
18MP0001727_abnormal_embryo_implantation2.13526236
19MP0002723_abnormal_immune_serum2.12909343
20MP0001346_abnormal_lacrimal_gland2.02944951
21MP0002452_abnormal_antigen_presenting1.96805629
22MP0001873_stomach_inflammation1.93300881
23MP0002420_abnormal_adaptive_immunity1.87546691
24MP0002398_abnormal_bone_marrow1.85288264
25MP0003890_abnormal_embryonic-extraembry1.85052484
26MP0001819_abnormal_immune_cell1.78925842
27MP0001881_abnormal_mammary_gland1.74057916
28MP0003329_amyloid_beta_deposits1.70801987
29MP0003077_abnormal_cell_cycle1.69849692
30MP0005025_abnormal_response_to1.69105397
31MP0000716_abnormal_immune_system1.67057514
32MP0009785_altered_susceptibility_to1.66736844
33MP0004957_abnormal_blastocyst_morpholog1.58744084
34MP0000703_abnormal_thymus_morphology1.54099733
35MP0000689_abnormal_spleen_morphology1.45365121
36MP0002722_abnormal_immune_system1.37872547
37MP0002429_abnormal_blood_cell1.37306411
38MP0004134_abnormal_chest_morphology1.35525846
39MP0010155_abnormal_intestine_physiology1.34919258
40MP0000350_abnormal_cell_proliferation1.28575330
41MP0003111_abnormal_nucleus_morphology1.27512032
42MP0001529_abnormal_vocalization1.27129365
43MP0002405_respiratory_system_inflammati1.25610690
44MP0010094_abnormal_chromosome_stability1.24748146
45MP0009046_muscle_twitch1.21369309
46MP0002006_tumorigenesis1.21239728
47MP0000566_synostosis1.20379259
48MP0004142_abnormal_muscle_tone1.17587245
49MP0002166_altered_tumor_susceptibility1.14614349
50MP0003693_abnormal_embryo_hatching1.12266132
51MP0005310_abnormal_salivary_gland1.09750947
52MP0002269_muscular_atrophy1.08895472
53MP0000631_abnormal_neuroendocrine_gland1.08460873
54MP0000313_abnormal_cell_death1.07302412
55MP0009333_abnormal_splenocyte_physiolog1.05564154
56MP0004808_abnormal_hematopoietic_stem1.03642397
57MP0004742_abnormal_vestibular_system1.03521694
58MP0001845_abnormal_inflammatory_respons1.03198671
59MP0003943_abnormal_hepatobiliary_system1.02835126
60MP0000537_abnormal_urethra_morphology1.02760167
61MP0001502_abnormal_circadian_rhythm0.97077909
62MP0003045_fibrosis0.93654351
63MP0001440_abnormal_grooming_behavior0.93433885
64MP0003186_abnormal_redox_activity0.90582983
65MP0008961_abnormal_basal_metabolism0.90421130
66MP0002019_abnormal_tumor_incidence0.87411219
67MP0002138_abnormal_hepatobiliary_system0.85544501
68MP0003866_abnormal_defecation0.84745573
69MP0002148_abnormal_hypersensitivity_rea0.84041722
70MP0008875_abnormal_xenobiotic_pharmacok0.83485546
71MP0005647_abnormal_sex_gland0.81665131
72MP0000604_amyloidosis0.80177560
73MP0002653_abnormal_ependyma_morphology0.76392343
74MP0002928_abnormal_bile_duct0.74936658
75MP0001919_abnormal_reproductive_system0.72875660
76MP0001853_heart_inflammation0.72568238
77MP0001730_embryonic_growth_arrest0.69721716
78MP0000747_muscle_weakness0.66733326
79MP0001533_abnormal_skeleton_physiology0.63849833
80MP0002009_preneoplasia0.63080797
81MP0004947_skin_inflammation0.62100485
82MP0002419_abnormal_innate_immunity0.61304893
83MP0000470_abnormal_stomach_morphology0.58353198
84MP0008469_abnormal_protein_level0.57255132
85MP0009840_abnormal_foam_cell0.57152859
86MP0008058_abnormal_DNA_repair0.55608457
87MP0001764_abnormal_homeostasis0.53649051
88MP0002693_abnormal_pancreas_physiology0.52989423
89MP0008004_abnormal_stomach_pH0.52284561
90MP0009250_abnormal_appendicular_skeleto0.51492072
91MP0005084_abnormal_gallbladder_morpholo0.50761163
92MP0003315_abnormal_perineum_morphology0.46584757
93MP0008932_abnormal_embryonic_tissue0.46028624
94MP0003634_abnormal_glial_cell0.45936589
95MP0003448_altered_tumor_morphology0.45293464
96MP0005330_cardiomyopathy0.45060035
97MP0000490_abnormal_crypts_of0.44941562
98MP0000372_irregular_coat_pigmentation0.44757384
99MP0005266_abnormal_metabolism0.44185874
100MP0003221_abnormal_cardiomyocyte_apopto0.43905105

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)5.88833734
2Recurrent bronchitis (HP:0002837)5.50356194
3Agammaglobulinemia (HP:0004432)5.25994437
4IgA deficiency (HP:0002720)5.11269752
5Recurrent sinusitis (HP:0011108)4.68266994
6IgG deficiency (HP:0004315)4.35156367
7IgM deficiency (HP:0002850)4.03059399
8Abnormality of macrophages (HP:0004311)3.80990280
9Chronic otitis media (HP:0000389)3.65140323
10Squamous cell carcinoma (HP:0002860)3.60180603
11Emphysema (HP:0002097)3.60174290
12Bronchitis (HP:0012387)3.59749468
13Hepatitis (HP:0012115)3.54470618
14Abnormality of T cell physiology (HP:0011840)3.41868385
15Increased IgM level (HP:0003496)3.38360094
16Lymphopenia (HP:0001888)3.37436859
17Entropion (HP:0000621)3.22844585
18Chronic diarrhea (HP:0002028)3.18039043
19Abnormality of cells of the lymphoid lineage (HP:0012140)3.17158366
20Overriding aorta (HP:0002623)3.14732967
21Meningitis (HP:0001287)3.11573197
22Basal cell carcinoma (HP:0002671)3.08101532
23Abnormality of DNA repair (HP:0003254)3.05164759
24Abnormal mitochondria in muscle tissue (HP:0008316)3.02195874
25Lymphoma (HP:0002665)2.94876938
26Recurrent cutaneous fungal infections (HP:0011370)2.93742444
27Chronic mucocutaneous candidiasis (HP:0002728)2.93742444
28Increased hepatocellular lipid droplets (HP:0006565)2.92175249
29Acute necrotizing encephalopathy (HP:0006965)2.90125519
30Insomnia (HP:0100785)2.87518877
31Lipid accumulation in hepatocytes (HP:0006561)2.87445574
32Cellulitis (HP:0100658)2.86198040
33Skin rash (HP:0000988)2.81898888
34Severe combined immunodeficiency (HP:0004430)2.80967667
35Conical tooth (HP:0000698)2.80292732
36Abnormality of T cells (HP:0002843)2.80211340
37Acute encephalopathy (HP:0006846)2.73823106
38Cutaneous melanoma (HP:0012056)2.73054138
39Dry hair (HP:0011359)2.67384731
40Atrophy/Degeneration involving motor neurons (HP:0007373)2.64837587
41Poikiloderma (HP:0001029)2.64546362
42Mitochondrial inheritance (HP:0001427)2.62003880
43Abnormal gallbladder physiology (HP:0012438)2.61561502
44Cholecystitis (HP:0001082)2.61561502
45Increased serum ferritin (HP:0003281)2.60475868
46Hyperacusis (HP:0010780)2.57899208
47Onycholysis (HP:0001806)2.57875889
48Abnormality of incisor morphology (HP:0011063)2.57467731
49Abnormal number of erythroid precursors (HP:0012131)2.57463330
50Increased muscle lipid content (HP:0009058)2.53311796
51Elfin facies (HP:0004428)2.50157746
52Increased intramyocellular lipid droplets (HP:0012240)2.50094340
53Aplastic anemia (HP:0001915)2.49168350
54Amyotrophic lateral sclerosis (HP:0007354)2.47291276
55Vasculitis (HP:0002633)2.45765113
56Elevated erythrocyte sedimentation rate (HP:0003565)2.43940461
57Recurrent skin infections (HP:0001581)2.40258672
58Nasal polyposis (HP:0100582)2.32642884
59Increased CSF lactate (HP:0002490)2.31260600
60Progressive macrocephaly (HP:0004481)2.30891792
61Abnormality of the anterior horn cell (HP:0006802)2.30634231
62Degeneration of anterior horn cells (HP:0002398)2.30634231
63Urticaria (HP:0001025)2.30518137
64Recurrent fungal infections (HP:0002841)2.29070124
65Retinal dysplasia (HP:0007973)2.28748315
66Recurrent otitis media (HP:0000403)2.28112187
67Verrucae (HP:0200043)2.26233835
68Papilloma (HP:0012740)2.26233835
69Abnormality of cells of the erythroid lineage (HP:0012130)2.23263647
70Stomatitis (HP:0010280)2.21358961
71Eczematoid dermatitis (HP:0000976)2.21133188
72Combined immunodeficiency (HP:0005387)2.20084002
73Recurrent bacterial skin infections (HP:0005406)2.18525039
74Mediastinal lymphadenopathy (HP:0100721)2.16005821
75Restrictive lung disease (HP:0002091)2.14590505
76Hypertensive crisis (HP:0100735)2.09364714
77Cerebral edema (HP:0002181)2.06158164
78Oral leukoplakia (HP:0002745)2.02588773
79Hepatocellular necrosis (HP:0001404)2.01407336
80Recurrent lower respiratory tract infections (HP:0002783)1.98509324
81Neutropenia (HP:0001875)1.98267561
82Bronchiectasis (HP:0002110)1.98005754
83Recurrent viral infections (HP:0004429)1.97168588
84Recurrent pneumonia (HP:0006532)1.96321527
85Abnormality of transition element cation homeostasis (HP:0011030)1.94178384
86Abnormality of the pons (HP:0007361)1.94052734
87Hypoplasia of the pons (HP:0012110)1.93759610
88Poor head control (HP:0002421)1.90365211
89Abnormality of the nasal mucosa (HP:0000433)1.90046951
90Exercise intolerance (HP:0003546)1.88566557
91Testicular atrophy (HP:0000029)1.87846096
92Abnormality of the common coagulation pathway (HP:0010990)1.87284987
93Respiratory difficulties (HP:0002880)1.86610338
94Cellular immunodeficiency (HP:0005374)1.86244344
95Sparse scalp hair (HP:0002209)1.85424450
96Leukopenia (HP:0001882)1.85367961
97Abnormality of iron homeostasis (HP:0011031)1.85017662
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83893257
99Renal Fanconi syndrome (HP:0001994)1.82568757
100Pancytopenia (HP:0001876)1.81263444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.79274842
2VRK15.70045246
3TLK15.43432511
4BCKDK3.94793115
5SMG13.73536201
6DAPK33.04249830
7DYRK22.64486572
8HIPK22.58502919
9CDK122.46290605
10RPS6KA52.36357314
11VRK22.32096225
12MAP3K122.15257752
13AURKA2.10022830
14MAP3K131.82040255
15EEF2K1.72428976
16NUAK11.70810266
17MAP4K11.69981643
18TAF11.47757527
19ARAF1.45051542
20ITK1.43926887
21IKBKB1.39068425
22NME21.33111713
23BUB11.28959039
24CHUK1.25215218
25ERN11.24595167
26AKT21.20160267
27MST41.18043248
28MAPKAPK31.16654990
29MAP3K141.06854186
30STK161.06258642
31TAOK31.01662916
32IRAK41.00661031
33MAP3K110.96672356
34KDR0.96593532
35EPHA30.95957615
36BRAF0.89715600
37ALK0.89690795
38NME10.88258651
39CDK190.87226069
40STK40.85176250
41AURKB0.84839749
42MOS0.83536876
43CHEK20.81993614
44JAK30.81323899
45PAK40.79914752
46CSNK1A1L0.79083872
47RPS6KB20.76599141
48LATS10.75721233
49RIPK40.75240359
50PIM10.69885947
51FGFR40.68832242
52MAPKAPK50.67775515
53CSF1R0.61802778
54SYK0.60135552
55DAPK10.55779096
56TESK20.54193426
57CSNK1G30.54183241
58BTK0.53370208
59TBK10.49693851
60MAP3K80.47992133
61LYN0.47835960
62MAP3K90.47209410
63CDC70.46325010
64MAP3K100.46029488
65KSR20.45623784
66PRKCQ0.44349864
67JAK20.41483519
68CSNK1G20.40521532
69NEK60.39541126
70ABL20.39123868
71PIM20.36379711
72CDK40.36027773
73PKN10.33764678
74IKBKE0.33636611
75JAK10.33387019
76PRKCH0.33367562
77PDK20.32418897
78EIF2AK20.31919663
79ATR0.31562754
80TAOK20.31279915
81STK100.30375047
82BLK0.30338717
83EIF2AK30.29662672
84PRKCD0.29320263
85PAK10.28564473
86CDK90.24708150
87EPHB10.23481134
88SIK10.23243524
89ILK0.22911746
90NEK10.22609062
91INSR0.22499297
92PDK10.21566437
93MAPKAPK20.21494738
94CHEK10.20385891
95SIK20.20307459
96MAP3K10.19918664
97MKNK20.18694848
98NEK90.18369360
99WEE10.17104356
100GRK50.17063294

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053228.02709226
2Alcoholism_Homo sapiens_hsa050345.26714518
3Primary immunodeficiency_Homo sapiens_hsa053403.89599093
4Allograft rejection_Homo sapiens_hsa053303.54020458
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.27977615
6Autoimmune thyroid disease_Homo sapiens_hsa053203.21471085
7Asthma_Homo sapiens_hsa053102.97658642
8Graft-versus-host disease_Homo sapiens_hsa053322.67149416
9Type I diabetes mellitus_Homo sapiens_hsa049402.43843466
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23412104
11Viral carcinogenesis_Homo sapiens_hsa052032.22744578
12Proteasome_Homo sapiens_hsa030502.09232013
13Viral myocarditis_Homo sapiens_hsa054161.99385954
14Antigen processing and presentation_Homo sapiens_hsa046121.96110221
15DNA replication_Homo sapiens_hsa030301.91315787
16Sulfur relay system_Homo sapiens_hsa041221.87635682
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.66687426
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65575224
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.60799065
20Oxidative phosphorylation_Homo sapiens_hsa001901.56455513
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54243373
22Ribosome_Homo sapiens_hsa030101.41203953
23Parkinsons disease_Homo sapiens_hsa050121.35388847
24Spliceosome_Homo sapiens_hsa030401.30282389
25Protein export_Homo sapiens_hsa030601.23425174
26Mismatch repair_Homo sapiens_hsa034301.21196627
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.03721700
28Epstein-Barr virus infection_Homo sapiens_hsa051691.03391913
29B cell receptor signaling pathway_Homo sapiens_hsa046621.02305599
30Glutathione metabolism_Homo sapiens_hsa004801.00796449
31Leishmaniasis_Homo sapiens_hsa051400.98002193
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96402078
33Nucleotide excision repair_Homo sapiens_hsa034200.94512398
34Huntingtons disease_Homo sapiens_hsa050160.93279728
35Alzheimers disease_Homo sapiens_hsa050100.88854222
36Biosynthesis of amino acids_Homo sapiens_hsa012300.87888106
37Apoptosis_Homo sapiens_hsa042100.81500835
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75886873
39p53 signaling pathway_Homo sapiens_hsa041150.73476196
40Herpes simplex infection_Homo sapiens_hsa051680.71981307
41Toxoplasmosis_Homo sapiens_hsa051450.71228760
42Rheumatoid arthritis_Homo sapiens_hsa053230.68676506
43Cardiac muscle contraction_Homo sapiens_hsa042600.65235797
44HTLV-I infection_Homo sapiens_hsa051660.63625512
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61876794
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60305600
47Selenocompound metabolism_Homo sapiens_hsa004500.60220204
48Phenylalanine metabolism_Homo sapiens_hsa003600.58459750
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56720089
50Hematopoietic cell lineage_Homo sapiens_hsa046400.54989202
51Base excision repair_Homo sapiens_hsa034100.54122244
52RNA transport_Homo sapiens_hsa030130.49532342
53RNA polymerase_Homo sapiens_hsa030200.48619016
54Purine metabolism_Homo sapiens_hsa002300.46655054
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46229718
56Measles_Homo sapiens_hsa051620.45906359
57Carbon metabolism_Homo sapiens_hsa012000.45207069
58Pyrimidine metabolism_Homo sapiens_hsa002400.43373107
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39643900
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37120823
61Pentose phosphate pathway_Homo sapiens_hsa000300.36791341
62Staphylococcus aureus infection_Homo sapiens_hsa051500.35803842
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33971310
64Fructose and mannose metabolism_Homo sapiens_hsa000510.32811251
65One carbon pool by folate_Homo sapiens_hsa006700.32725760
66Homologous recombination_Homo sapiens_hsa034400.32412812
67Phagosome_Homo sapiens_hsa041450.32349294
68Influenza A_Homo sapiens_hsa051640.32032952
69RNA degradation_Homo sapiens_hsa030180.31415898
70Hepatitis B_Homo sapiens_hsa051610.29996022
71Cell cycle_Homo sapiens_hsa041100.29661821
72Tuberculosis_Homo sapiens_hsa051520.29396096
73Vibrio cholerae infection_Homo sapiens_hsa051100.29218776
74T cell receptor signaling pathway_Homo sapiens_hsa046600.27448440
75Steroid biosynthesis_Homo sapiens_hsa001000.26761060
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23058334
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21962866
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17507806
79Pyruvate metabolism_Homo sapiens_hsa006200.16981268
80Nitrogen metabolism_Homo sapiens_hsa009100.16971123
81Tryptophan metabolism_Homo sapiens_hsa003800.16739707
82N-Glycan biosynthesis_Homo sapiens_hsa005100.16715589
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13229140
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12995374
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12976976
86Propanoate metabolism_Homo sapiens_hsa006400.12715561
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10803684
88Shigellosis_Homo sapiens_hsa051310.10530826
89Acute myeloid leukemia_Homo sapiens_hsa052210.08266708
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.08246011
91Prion diseases_Homo sapiens_hsa050200.07474796
92Phototransduction_Homo sapiens_hsa047440.07158823
93Legionellosis_Homo sapiens_hsa051340.07056057
94Vitamin digestion and absorption_Homo sapiens_hsa049770.06768151
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.05955689
96Small cell lung cancer_Homo sapiens_hsa052220.05521792
97Chemokine signaling pathway_Homo sapiens_hsa040620.03994379
98Metabolic pathways_Homo sapiens_hsa011000.02788924
99mRNA surveillance pathway_Homo sapiens_hsa030150.02650936
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.02588762

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