SETD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.45308183
2CENP-A containing nucleosome assembly (GO:0034080)5.15585427
3chromatin remodeling at centromere (GO:0031055)5.08674500
4proteasome assembly (GO:0043248)4.84052917
5histone exchange (GO:0043486)4.51359649
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.48159185
7protein neddylation (GO:0045116)4.27272625
8rRNA modification (GO:0000154)4.21176245
9ribosomal large subunit biogenesis (GO:0042273)4.02282485
10protein complex biogenesis (GO:0070271)4.00532595
11mitochondrial respiratory chain complex assembly (GO:0033108)3.91197793
12DNA replication-independent nucleosome assembly (GO:0006336)3.84902596
13DNA replication-independent nucleosome organization (GO:0034724)3.84902596
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84018766
15ATP synthesis coupled proton transport (GO:0015986)3.80032400
16energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80032400
17ribosomal small subunit biogenesis (GO:0042274)3.73535716
18purine nucleobase biosynthetic process (GO:0009113)3.68195174
19viral transcription (GO:0019083)3.67378427
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.66789736
21translational termination (GO:0006415)3.63488123
22pseudouridine synthesis (GO:0001522)3.62425565
23DNA replication checkpoint (GO:0000076)3.61998744
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59985465
25base-excision repair, AP site formation (GO:0006285)3.56998759
26cullin deneddylation (GO:0010388)3.55488551
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54659390
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.53918141
29NADH dehydrogenase complex assembly (GO:0010257)3.53918141
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53918141
31formation of translation preinitiation complex (GO:0001731)3.52541671
32translational initiation (GO:0006413)3.51943855
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51194163
34respiratory chain complex IV assembly (GO:0008535)3.50659159
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49395952
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49395952
37negative regulation of ligase activity (GO:0051352)3.48981213
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48981213
39cotranslational protein targeting to membrane (GO:0006613)3.47852151
40rRNA methylation (GO:0031167)3.45942888
41chaperone-mediated protein transport (GO:0072321)3.42720983
42protein targeting to ER (GO:0045047)3.41854162
43DNA catabolic process, exonucleolytic (GO:0000738)3.39936910
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39540983
45telomere maintenance via semi-conservative replication (GO:0032201)3.39213001
46DNA double-strand break processing (GO:0000729)3.38764657
47mitotic metaphase plate congression (GO:0007080)3.33920235
48synapsis (GO:0007129)3.31853382
49regulation of meiosis I (GO:0060631)3.31086447
50ribosome assembly (GO:0042255)3.30884005
51translation (GO:0006412)3.30263839
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.28838175
53nucleobase biosynthetic process (GO:0046112)3.28176310
54protein localization to endoplasmic reticulum (GO:0070972)3.27765841
55cellular component biogenesis (GO:0044085)3.27709743
56protein deneddylation (GO:0000338)3.27631806
57deoxyribonucleotide catabolic process (GO:0009264)3.25536963
58establishment of integrated proviral latency (GO:0075713)3.25469054
59ribonucleoprotein complex biogenesis (GO:0022613)3.23710291
60DNA ligation (GO:0006266)3.23701804
61deoxyribose phosphate catabolic process (GO:0046386)3.22059389
62cytochrome complex assembly (GO:0017004)3.21700210
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21475995
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19887505
65DNA strand elongation involved in DNA replication (GO:0006271)3.19747977
66IMP biosynthetic process (GO:0006188)3.19028084
67translational elongation (GO:0006414)3.18519267
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18400287
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17330486
70rRNA processing (GO:0006364)3.16213740
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16106788
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16106788
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16106788
74regulation of cellular amino acid metabolic process (GO:0006521)3.15485866
75regulation of mitochondrial translation (GO:0070129)3.15430595
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12973208
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12973208
78histone mRNA metabolic process (GO:0008334)3.10940442
79transcription from mitochondrial promoter (GO:0006390)3.10815101
80regulation of centriole replication (GO:0046599)3.10520754
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.08692047
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08002694
83maturation of SSU-rRNA (GO:0030490)3.07289079
84signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06125540
85signal transduction involved in DNA damage checkpoint (GO:0072422)3.06125540
86DNA strand elongation (GO:0022616)3.04374374
87regulation of mitotic spindle checkpoint (GO:1903504)3.03404293
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03404293
89positive regulation of ligase activity (GO:0051351)3.03073379
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.02991853
91mitochondrial RNA metabolic process (GO:0000959)3.02955050
92DNA replication-dependent nucleosome assembly (GO:0006335)3.02869595
93DNA replication-dependent nucleosome organization (GO:0034723)3.02869595
94rRNA metabolic process (GO:0016072)3.02797175
95metaphase plate congression (GO:0051310)3.01692429
96maturation of 5.8S rRNA (GO:0000460)3.01626632
97signal transduction involved in cell cycle checkpoint (GO:0072395)3.00751124
98purine deoxyribonucleotide catabolic process (GO:0009155)2.99683397
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99511474
100telomere maintenance via recombination (GO:0000722)2.95707776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.08597018
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.54653878
3E2F7_22180533_ChIP-Seq_HELA_Human4.19123332
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.06410640
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.85891094
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40833514
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33120409
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30822471
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.09833951
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01108499
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00520394
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88884959
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84208093
14VDR_23849224_ChIP-Seq_CD4+_Human2.82327980
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76008866
16ELK1_19687146_ChIP-ChIP_HELA_Human2.72395797
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64963432
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64904082
19FOXP3_21729870_ChIP-Seq_TREG_Human2.63400384
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55904202
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52695153
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46583308
23DCP1A_22483619_ChIP-Seq_HELA_Human2.25673435
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18888479
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16623744
26TTF2_22483619_ChIP-Seq_HELA_Human2.14665948
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06721476
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06338664
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.02020424
30PADI4_21655091_ChIP-ChIP_MCF-7_Human2.01432062
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01356951
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.96714835
33XRN2_22483619_ChIP-Seq_HELA_Human1.96426376
34GABP_19822575_ChIP-Seq_HepG2_Human1.93770500
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92517794
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.91839061
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90549328
38AR_21909140_ChIP-Seq_LNCAP_Human1.84028989
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74117794
40FUS_26573619_Chip-Seq_HEK293_Human1.73319835
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.72953358
42MYC_18940864_ChIP-ChIP_HL60_Human1.71760348
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70928271
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70037467
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65702026
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65485292
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52976750
48EWS_26573619_Chip-Seq_HEK293_Human1.47899723
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47645929
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46099145
51IGF1R_20145208_ChIP-Seq_DFB_Human1.44655322
52ZNF274_21170338_ChIP-Seq_K562_Hela1.43762113
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39649757
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39646017
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37645644
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.33360957
57VDR_22108803_ChIP-Seq_LS180_Human1.33241891
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30731053
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26336152
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25412969
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20039886
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19410731
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18589504
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14055741
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09776580
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09707061
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.07365127
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07201767
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06284052
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.03131648
71KDM5A_27292631_Chip-Seq_BREAST_Human1.00483237
72TFEB_21752829_ChIP-Seq_HELA_Human1.00106296
73SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99581562
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98088365
75IRF1_19129219_ChIP-ChIP_H3396_Human0.96911695
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96083155
77NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94549840
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93017970
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92521527
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92225218
81CIITA_25753668_ChIP-Seq_RAJI_Human0.87983865
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.85723049
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84471309
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83108838
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82708797
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.82127756
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.80461921
88ELF5_23300383_ChIP-Seq_T47D_Human0.80125394
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.77940657
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77304859
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77104603
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75264698
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75194009
94TP53_22573176_ChIP-Seq_HFKS_Human0.74476836
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.73598991
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72756600
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.72414506
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71418623
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70777478
100TAF15_26573619_Chip-Seq_HEK293_Human0.68978861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.66784904
2MP0010094_abnormal_chromosome_stability3.79354811
3MP0004957_abnormal_blastocyst_morpholog3.61070603
4MP0002132_abnormal_respiratory_system3.21993269
5MP0009697_abnormal_copulation3.20122716
6MP0003806_abnormal_nucleotide_metabolis3.16670321
7MP0003077_abnormal_cell_cycle3.12061813
8MP0003693_abnormal_embryo_hatching3.07479616
9MP0003111_abnormal_nucleus_morphology3.03107791
10MP0003786_premature_aging2.89087653
11MP0003186_abnormal_redox_activity2.82553120
12MP0006292_abnormal_olfactory_placode2.67851958
13MP0008932_abnormal_embryonic_tissue2.55135347
14MP0005410_abnormal_fertilization2.51541323
15MP0008877_abnormal_DNA_methylation2.36620485
16MP0003718_maternal_effect2.35990077
17MP0006036_abnormal_mitochondrial_physio2.24253531
18MP0005084_abnormal_gallbladder_morpholo2.22125526
19MP0005075_abnormal_melanosome_morpholog2.09445109
20MP0001853_heart_inflammation2.06399518
21MP0002138_abnormal_hepatobiliary_system2.05434239
22MP0008007_abnormal_cellular_replicative2.02855546
23MP0008995_early_reproductive_senescence2.02029637
24MP0006054_spinal_hemorrhage1.82402141
25MP0002938_white_spotting1.81797226
26MP0008004_abnormal_stomach_pH1.79964422
27MP0003941_abnormal_skin_development1.76190514
28MP0001929_abnormal_gametogenesis1.67039847
29MP0006035_abnormal_mitochondrial_morpho1.63569396
30MP0002210_abnormal_sex_determination1.53641175
31MP0008057_abnormal_DNA_replication1.47997888
32MP0001529_abnormal_vocalization1.45287771
33MP0002160_abnormal_reproductive_system1.39113344
34MP0001293_anophthalmia1.37870975
35MP0009379_abnormal_foot_pigmentation1.37838223
36MP0002837_dystrophic_cardiac_calcinosis1.37779397
37MP0008789_abnormal_olfactory_epithelium1.37158180
38MP0003890_abnormal_embryonic-extraembry1.36314704
39MP0001145_abnormal_male_reproductive1.34699308
40MP0003252_abnormal_bile_duct1.34503221
41MP0000372_irregular_coat_pigmentation1.30511001
42MP0003646_muscle_fatigue1.26780602
43MP0001727_abnormal_embryo_implantation1.26027310
44MP0003283_abnormal_digestive_organ1.24366113
45MP0003195_calcinosis1.21774737
46MP0000653_abnormal_sex_gland1.21606445
47MP0003698_abnormal_male_reproductive1.20639731
48MP0001697_abnormal_embryo_size1.19954155
49MP0003136_yellow_coat_color1.19396862
50MP0006072_abnormal_retinal_apoptosis1.19319433
51MP0001764_abnormal_homeostasis1.19197578
52MP0003567_abnormal_fetal_cardiomyocyte1.13760657
53MP0000350_abnormal_cell_proliferation1.11040942
54MP0005380_embryogenesis_phenotype1.10811316
55MP0001672_abnormal_embryogenesis/_devel1.10811316
56MP0000313_abnormal_cell_death1.06865306
57MP0000358_abnormal_cell_content/1.06532276
58MP0004147_increased_porphyrin_level1.05349069
59MP0001730_embryonic_growth_arrest1.01786118
60MP0001485_abnormal_pinna_reflex0.96986633
61MP0002080_prenatal_lethality0.94565569
62MP0002084_abnormal_developmental_patter0.93006595
63MP0005394_taste/olfaction_phenotype0.89715645
64MP0005499_abnormal_olfactory_system0.89715645
65MP0003984_embryonic_growth_retardation0.89514405
66MP0002638_abnormal_pupillary_reflex0.89302215
67MP0002088_abnormal_embryonic_growth/wei0.87963475
68MP0005220_abnormal_exocrine_pancreas0.83855727
69MP0002085_abnormal_embryonic_tissue0.82432036
70MP0005670_abnormal_white_adipose0.81718201
71MP0005408_hypopigmentation0.79983575
72MP0005332_abnormal_amino_acid0.79649603
73MP0001661_extended_life_span0.78845443
74MP0000749_muscle_degeneration0.76879326
75MP0005395_other_phenotype0.76318303
76MP0002736_abnormal_nociception_after0.75485071
77MP0004215_abnormal_myocardial_fiber0.75456068
78MP0005330_cardiomyopathy0.74707071
79MP0005389_reproductive_system_phenotype0.73795552
80MP0005085_abnormal_gallbladder_physiolo0.73639582
81MP0000049_abnormal_middle_ear0.72483405
82MP0001119_abnormal_female_reproductive0.71233616
83MP0002019_abnormal_tumor_incidence0.71034112
84MP0002277_abnormal_respiratory_mucosa0.69273895
85MP0002254_reproductive_system_inflammat0.68449824
86MP0010030_abnormal_orbit_morphology0.67824784
87MP0000013_abnormal_adipose_tissue0.67196498
88MP0003937_abnormal_limbs/digits/tail_de0.67025844
89MP0002102_abnormal_ear_morphology0.66484525
90MP0004133_heterotaxia0.65800481
91MP0002161_abnormal_fertility/fecundity0.64915714
92MP0001666_abnormal_nutrient_absorption0.63433447
93MP0004084_abnormal_cardiac_muscle0.63243145
94MP0000613_abnormal_salivary_gland0.60937790
95MP0010386_abnormal_urinary_bladder0.60442820
96MP0008875_abnormal_xenobiotic_pharmacok0.60359795
97MP0000516_abnormal_urinary_system0.59519876
98MP0005367_renal/urinary_system_phenotyp0.59519876
99MP0002269_muscular_atrophy0.59110371
100MP0005379_endocrine/exocrine_gland_phen0.58411984

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.77328893
2Lipid accumulation in hepatocytes (HP:0006561)4.60764279
3Acute necrotizing encephalopathy (HP:0006965)4.56290081
4Acute encephalopathy (HP:0006846)4.30914385
5Renal Fanconi syndrome (HP:0001994)4.30381322
6Increased CSF lactate (HP:0002490)4.25841075
7Abnormal mitochondria in muscle tissue (HP:0008316)4.22330679
8Mitochondrial inheritance (HP:0001427)4.09153640
9Progressive macrocephaly (HP:0004481)3.69466102
10Type I transferrin isoform profile (HP:0003642)3.45388774
11Exertional dyspnea (HP:0002875)3.37544156
12Hepatocellular necrosis (HP:0001404)3.36886261
13Increased serum lactate (HP:0002151)3.20313678
14Cerebral edema (HP:0002181)3.16231619
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14091668
16Abnormality of alanine metabolism (HP:0010916)3.14091668
17Hyperalaninemia (HP:0003348)3.14091668
18Increased intramyocellular lipid droplets (HP:0012240)3.12028922
19Reticulocytopenia (HP:0001896)3.12025468
20Reduced antithrombin III activity (HP:0001976)3.03983763
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00063418
22Hepatic necrosis (HP:0002605)2.97021697
23Lactic acidosis (HP:0003128)2.82836936
24Macrocytic anemia (HP:0001972)2.81100048
25Aplastic anemia (HP:0001915)2.80737470
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76112451
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76112451
28Respiratory difficulties (HP:0002880)2.70713247
29Increased muscle lipid content (HP:0009058)2.70596692
30Congenital, generalized hypertrichosis (HP:0004540)2.70071010
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67455411
32Abnormality of renal resorption (HP:0011038)2.65837584
33Abnormality of cells of the erythroid lineage (HP:0012130)2.65634560
34Abnormality of methionine metabolism (HP:0010901)2.64406508
35Oral leukoplakia (HP:0002745)2.61230936
36Abnormal number of erythroid precursors (HP:0012131)2.58451513
37Exercise intolerance (HP:0003546)2.53882101
38Pancytopenia (HP:0001876)2.52538050
39Stenosis of the external auditory canal (HP:0000402)2.52075582
40Degeneration of anterior horn cells (HP:0002398)2.50961729
41Abnormality of the anterior horn cell (HP:0006802)2.50961729
42Abnormal spermatogenesis (HP:0008669)2.50576676
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47019112
44Respiratory failure (HP:0002878)2.46388220
45Abnormality of urine glucose concentration (HP:0011016)2.45281289
46Glycosuria (HP:0003076)2.45281289
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43912537
48Abnormal protein N-linked glycosylation (HP:0012347)2.43912537
49Abnormal protein glycosylation (HP:0012346)2.43912537
50Abnormal glycosylation (HP:0012345)2.43912537
51Abnormality of placental membranes (HP:0011409)2.38657884
52Amniotic constriction ring (HP:0009775)2.38657884
53Abnormality of serum amino acid levels (HP:0003112)2.34866494
54Rough bone trabeculation (HP:0100670)2.31982190
553-Methylglutaconic aciduria (HP:0003535)2.31525494
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29571212
57Meckel diverticulum (HP:0002245)2.29290792
58Colon cancer (HP:0003003)2.24545145
59Increased serum pyruvate (HP:0003542)2.21757885
60Leukodystrophy (HP:0002415)2.20180456
61Lethargy (HP:0001254)2.17453890
62Microvesicular hepatic steatosis (HP:0001414)2.17237208
63Abnormality of the ileum (HP:0001549)2.16104409
64Chromsome breakage (HP:0040012)2.15232206
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.13847629
66Abnormality of chromosome stability (HP:0003220)2.12229317
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11092598
68Methylmalonic acidemia (HP:0002912)2.10717262
69Hypoplasia of the pons (HP:0012110)2.03372610
70Hyperglycinemia (HP:0002154)2.02368035
71Abnormality of the preputium (HP:0100587)2.02268016
72Birth length less than 3rd percentile (HP:0003561)2.02075402
73Small intestinal stenosis (HP:0012848)2.01553756
74Duodenal stenosis (HP:0100867)2.01553756
75Azoospermia (HP:0000027)2.00746842
76Pallor (HP:0000980)1.99849748
77True hermaphroditism (HP:0010459)1.99713173
78Hyperphosphaturia (HP:0003109)1.98473007
79Optic disc pallor (HP:0000543)1.97609697
80Carpal bone hypoplasia (HP:0001498)1.96768152
81CNS demyelination (HP:0007305)1.96732614
82Progressive muscle weakness (HP:0003323)1.94543128
83Abnormality of the pons (HP:0007361)1.93990366
84Abnormal trabecular bone morphology (HP:0100671)1.93353471
85Type 2 muscle fiber atrophy (HP:0003554)1.91706178
86Generalized aminoaciduria (HP:0002909)1.90141653
87Pancreatic cysts (HP:0001737)1.89430886
88Abnormal lung lobation (HP:0002101)1.87063611
89Nephronophthisis (HP:0000090)1.85527138
90Absent thumb (HP:0009777)1.83791855
91Pancreatic fibrosis (HP:0100732)1.82063434
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.81658067
93Absent/shortened dynein arms (HP:0200106)1.81658067
94Abnormality of sulfur amino acid metabolism (HP:0004339)1.79586471
95Myelodysplasia (HP:0002863)1.79204623
96Horseshoe kidney (HP:0000085)1.78407669
97Aplasia/hypoplasia of the uterus (HP:0008684)1.78267072
98Gonadotropin excess (HP:0000837)1.77187172
99Median cleft lip (HP:0000161)1.75545734
100Secondary amenorrhea (HP:0000869)1.73940311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.59094414
2MST43.73248840
3ZAK3.60552668
4PBK3.38165961
5CDK193.34316750
6BUB13.22413252
7EIF2AK12.68746321
8PLK42.65599891
9VRK22.65022562
10EIF2AK32.48027651
11BRSK22.39924592
12WEE12.37323290
13VRK12.13156632
14CDC72.11127994
15TLK12.07539757
16TTK2.06362609
17NEK12.02820728
18SRPK11.95531022
19CCNB11.95237723
20MAP3K121.90080480
21NME21.83683708
22PLK31.75811735
23TRIM281.67696962
24TSSK61.52504074
25PLK11.45098632
26PDK21.43281998
27MKNK11.32995035
28PLK21.30166533
29NUAK11.28081647
30MKNK21.24926978
31BMPR1B1.20494465
32WNK31.19405332
33BCKDK1.13129976
34PASK1.11820210
35TAF11.05034191
36MUSK1.02024063
37PNCK1.00817454
38MAP4K20.98001816
39BRSK10.91377031
40NME10.90413683
41LMTK20.89340759
42AURKB0.88603159
43RPS6KB20.85295376
44SCYL20.84186763
45CHEK20.81374102
46STK38L0.79168891
47INSRR0.79103404
48ATR0.78259441
49PAK40.77849490
50MYLK0.72107173
51BMPR20.66248663
52RPS6KA50.65118781
53ACVR1B0.63303522
54TGFBR10.62857509
55GRK10.61743201
56TEC0.60050030
57STK40.59413707
58CSNK2A10.58502288
59DAPK30.57389272
60BRD40.56403748
61ABL20.54744808
62CDK70.54534147
63TNIK0.53938247
64ILK0.52444607
65CSNK2A20.51016834
66AURKA0.50467872
67MATK0.47882527
68EIF2AK20.47452582
69NEK20.45555593
70ATM0.45332429
71FLT30.43754234
72OXSR10.43555760
73STK30.43372431
74DAPK10.43255500
75DYRK30.42200391
76CHEK10.41146316
77MARK30.37849717
78ADRBK20.37186907
79PINK10.36160870
80ERBB30.36012008
81CSNK1G10.35654947
82MAP3K80.34655741
83CDK80.34277007
84OBSCN0.33386809
85AKT20.33118904
86DYRK20.29715251
87KIT0.28839253
88CSNK1G30.27170254
89TIE10.26205653
90PIM20.26120355
91MAP3K50.25978824
92STK100.24695563
93BRAF0.24430818
94PRKCE0.21940038
95PRKCI0.20976798
96STK390.20038698
97ERBB40.19388642
98CDK90.19068952
99CSNK1G20.18901757
100CLK10.17976523

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.23193421
2Ribosome_Homo sapiens_hsa030103.88707323
3DNA replication_Homo sapiens_hsa030303.42910027
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16529378
5Mismatch repair_Homo sapiens_hsa034303.15658236
6Base excision repair_Homo sapiens_hsa034102.99968190
7Oxidative phosphorylation_Homo sapiens_hsa001902.74678101
8Protein export_Homo sapiens_hsa030602.52869722
9Parkinsons disease_Homo sapiens_hsa050122.50855622
10RNA polymerase_Homo sapiens_hsa030202.48401656
11Homologous recombination_Homo sapiens_hsa034402.48110938
12RNA transport_Homo sapiens_hsa030132.28132528
13Spliceosome_Homo sapiens_hsa030402.10037623
14Nucleotide excision repair_Homo sapiens_hsa034202.09879085
15Fanconi anemia pathway_Homo sapiens_hsa034602.00628342
16One carbon pool by folate_Homo sapiens_hsa006701.99536469
17Huntingtons disease_Homo sapiens_hsa050161.85448311
18Pyrimidine metabolism_Homo sapiens_hsa002401.82315526
19Non-homologous end-joining_Homo sapiens_hsa034501.79654392
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78234091
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78020720
22Basal transcription factors_Homo sapiens_hsa030221.77565851
23RNA degradation_Homo sapiens_hsa030181.75488920
24Propanoate metabolism_Homo sapiens_hsa006401.67289325
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.57622099
26Purine metabolism_Homo sapiens_hsa002301.37236897
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35742773
28Alzheimers disease_Homo sapiens_hsa050101.34342621
29Cell cycle_Homo sapiens_hsa041101.34253680
30Glutathione metabolism_Homo sapiens_hsa004801.33519891
31Pyruvate metabolism_Homo sapiens_hsa006201.32693761
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24849793
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19142256
34Sulfur metabolism_Homo sapiens_hsa009201.14567898
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13140154
36Folate biosynthesis_Homo sapiens_hsa007901.11595132
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10470581
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07215906
39Systemic lupus erythematosus_Homo sapiens_hsa053221.04577106
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02822994
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02473130
42Peroxisome_Homo sapiens_hsa041461.01961436
43Sulfur relay system_Homo sapiens_hsa041221.01850307
44Fatty acid elongation_Homo sapiens_hsa000620.99417449
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97957087
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94023189
47mRNA surveillance pathway_Homo sapiens_hsa030150.89845879
48Selenocompound metabolism_Homo sapiens_hsa004500.83370532
49Asthma_Homo sapiens_hsa053100.81340846
50Carbon metabolism_Homo sapiens_hsa012000.81033867
51Vitamin B6 metabolism_Homo sapiens_hsa007500.77428585
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77323280
53p53 signaling pathway_Homo sapiens_hsa041150.76990676
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76267737
55Metabolic pathways_Homo sapiens_hsa011000.75392705
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.74799364
57Biosynthesis of amino acids_Homo sapiens_hsa012300.73553196
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72949740
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72612573
60Chemical carcinogenesis_Homo sapiens_hsa052040.72278098
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.71073726
62Retinol metabolism_Homo sapiens_hsa008300.68587831
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67066876
64Fatty acid degradation_Homo sapiens_hsa000710.66422311
65Butanoate metabolism_Homo sapiens_hsa006500.65445361
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64153078
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63172186
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61050062
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60755069
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60348340
71Oocyte meiosis_Homo sapiens_hsa041140.59671984
72Vitamin digestion and absorption_Homo sapiens_hsa049770.57998927
73Legionellosis_Homo sapiens_hsa051340.55861283
74TGF-beta signaling pathway_Homo sapiens_hsa043500.55170635
75Cardiac muscle contraction_Homo sapiens_hsa042600.54758777
76Caffeine metabolism_Homo sapiens_hsa002320.50766583
77N-Glycan biosynthesis_Homo sapiens_hsa005100.49852420
78Steroid biosynthesis_Homo sapiens_hsa001000.48351189
79Arginine and proline metabolism_Homo sapiens_hsa003300.42493223
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.38772381
81Alcoholism_Homo sapiens_hsa050340.36676002
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36630334
83Tyrosine metabolism_Homo sapiens_hsa003500.36448506
84Fatty acid metabolism_Homo sapiens_hsa012120.36337368
85Tryptophan metabolism_Homo sapiens_hsa003800.32673096
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.32527429
87Epstein-Barr virus infection_Homo sapiens_hsa051690.32310453
88Phototransduction_Homo sapiens_hsa047440.29361457
89Regulation of autophagy_Homo sapiens_hsa041400.28513855
90beta-Alanine metabolism_Homo sapiens_hsa004100.28227703
91Starch and sucrose metabolism_Homo sapiens_hsa005000.25941772
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25766272
93Nitrogen metabolism_Homo sapiens_hsa009100.24549834
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21318990
95Fat digestion and absorption_Homo sapiens_hsa049750.20484471
96Allograft rejection_Homo sapiens_hsa053300.19505975
97Collecting duct acid secretion_Homo sapiens_hsa049660.18978128
98Rheumatoid arthritis_Homo sapiens_hsa053230.18715428
99Type I diabetes mellitus_Homo sapiens_hsa049400.16890058
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16695516

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