SETDB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18787185
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18787185
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.16044475
4B cell receptor signaling pathway (GO:0050853)4.14979984
5positive regulation of interferon-alpha production (GO:0032727)4.12290855
6antigen processing and presentation of endogenous antigen (GO:0019883)4.02114468
7interkinetic nuclear migration (GO:0022027)4.01876897
8natural killer cell mediated immunity (GO:0002228)3.98343334
9natural killer cell mediated cytotoxicity (GO:0042267)3.98343334
10positive regulation of granulocyte differentiation (GO:0030854)3.93843264
11regulation of interferon-alpha production (GO:0032647)3.91506111
12regulation of RIG-I signaling pathway (GO:0039535)3.88493152
13modulation by symbiont of host immune response (GO:0052553)3.81309191
14positive regulation by symbiont of host defense response (GO:0052509)3.81309191
15modulation by symbiont of host defense response (GO:0052031)3.81309191
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.81309191
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.81309191
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.81309191
19type I interferon signaling pathway (GO:0060337)3.78044508
20cellular response to type I interferon (GO:0071357)3.78044508
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.76260783
22response to type I interferon (GO:0034340)3.75899695
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.63741384
24regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.56532396
25positive regulation of gamma-delta T cell activation (GO:0046645)3.55338326
26immunoglobulin mediated immune response (GO:0016064)3.54772944
27mast cell activation (GO:0045576)3.52543809
28negative T cell selection (GO:0043383)3.51974096
29mast cell degranulation (GO:0043303)3.49351182
30mast cell activation involved in immune response (GO:0002279)3.49351182
31interferon-gamma production (GO:0032609)3.44041388
32positive T cell selection (GO:0043368)3.43956618
33positive thymic T cell selection (GO:0045059)3.39240186
34negative thymic T cell selection (GO:0045060)3.37064135
35response to interferon-alpha (GO:0035455)3.35746101
36activated T cell proliferation (GO:0050798)3.34707982
37neutrophil activation involved in immune response (GO:0002283)3.33252379
38cellular extravasation (GO:0045123)3.31705107
39positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.29752054
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29269976
41negative regulation of cell killing (GO:0031342)3.27823390
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27823390
43positive regulation of interferon-beta production (GO:0032728)3.25856236
44T cell migration (GO:0072678)3.25779523
45regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.24419631
46NIK/NF-kappaB signaling (GO:0038061)3.23733991
47positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18321652
48cellular response to exogenous dsRNA (GO:0071360)3.10145842
49purinergic nucleotide receptor signaling pathway (GO:0035590)3.03961588
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03816174
51cellular response to interferon-alpha (GO:0035457)3.03619667
52negative regulation of viral genome replication (GO:0045071)2.99371590
53B cell mediated immunity (GO:0019724)2.98564303
54positive regulation of mast cell activation (GO:0033005)2.95788426
55cellular response to virus (GO:0098586)2.95495348
56regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92713832
57regulation of granulocyte differentiation (GO:0030852)2.89680094
58response to protozoan (GO:0001562)2.89152456
59regulation of mast cell activation (GO:0033003)2.87990062
60cellular response to interferon-beta (GO:0035458)2.86898213
61piRNA metabolic process (GO:0034587)2.86105237
62regulation of interferon-beta biosynthetic process (GO:0045357)2.85662178
63myeloid cell activation involved in immune response (GO:0002275)2.85404956
64antigen receptor-mediated signaling pathway (GO:0050851)2.83746927
65positive regulation of T cell cytokine production (GO:0002726)2.82605138
66positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80925057
67response to interleukin-15 (GO:0070672)2.78273374
68nuclear pore complex assembly (GO:0051292)2.78053512
69regulation of T cell mediated cytotoxicity (GO:0001914)2.76845073
70leukocyte mediated cytotoxicity (GO:0001909)2.75966024
71rRNA catabolic process (GO:0016075)2.75598950
72negative regulation of T cell mediated immunity (GO:0002710)2.72977739
73negative regulation of interleukin-12 production (GO:0032695)2.72561601
74cell wall macromolecule catabolic process (GO:0016998)2.71262431
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.70981005
76interferon-gamma-mediated signaling pathway (GO:0060333)2.70191615
77negative regulation of interleukin-17 production (GO:0032700)2.69869200
78response to peptidoglycan (GO:0032494)2.69739681
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69399822
80response to host immune response (GO:0052572)2.69399822
81leukocyte degranulation (GO:0043299)2.67791387
82T cell selection (GO:0045058)2.65662505
83positive regulation of natural killer cell differentiation (GO:0032825)2.64839744
84neutrophil mediated immunity (GO:0002446)2.63166101
85attachment of spindle microtubules to kinetochore (GO:0008608)2.61575296
86positive regulation of mast cell degranulation (GO:0043306)2.60988291
87positive regulation of mast cell activation involved in immune response (GO:0033008)2.60988291
88positive regulation of antigen processing and presentation (GO:0002579)2.60611687
89positive regulation of humoral immune response (GO:0002922)2.60345737
90DNA deamination (GO:0045006)2.59651334
91positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.59239036
92nuclear pore organization (GO:0006999)2.58979060
93definitive hemopoiesis (GO:0060216)2.58609486
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.58485993
95cellular response to ethanol (GO:0071361)2.58433266
96regulation of interferon-beta production (GO:0032648)2.58165843
97negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.57998493
98negative regulation of mast cell activation (GO:0033004)2.57405708
99regulation of response to interferon-gamma (GO:0060330)2.57004290
100cellular response to interleukin-15 (GO:0071350)2.55710822
101Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55597472
102positive regulation of response to biotic stimulus (GO:0002833)2.54792699
103microglial cell activation (GO:0001774)2.54199759
104positive regulation of defense response to virus by host (GO:0002230)2.53669278
105defense response to virus (GO:0051607)2.53251862
106positive regulation of alpha-beta T cell activation (GO:0046635)2.52679068
107positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.51103960
108axoneme assembly (GO:0035082)2.51091876
109regulation of gamma-delta T cell activation (GO:0046643)2.49748568
110regulation of defense response to virus by host (GO:0050691)2.49162268
111B cell activation (GO:0042113)2.48994317
112actin nucleation (GO:0045010)2.48953025
113lymphoid progenitor cell differentiation (GO:0002320)2.48927215
114regulation of female gonad development (GO:2000194)2.48770900
115DNA replication checkpoint (GO:0000076)2.48149862
116regulation of interleukin-12 biosynthetic process (GO:0045075)2.47913222
117regulation of MHC class II biosynthetic process (GO:0045346)2.47862093
118respiratory burst (GO:0045730)2.46769113
119phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.46352785
120regulation of T cell receptor signaling pathway (GO:0050856)2.46352654
121regulation of interleukin-6 biosynthetic process (GO:0045408)2.46139453
122granulocyte activation (GO:0036230)2.46078233
123regulation of alpha-beta T cell activation (GO:0046634)2.45625049
124regulation of natural killer cell mediated immunity (GO:0002715)2.45353419
125regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.45353419
126regulation of antigen processing and presentation (GO:0002577)2.45269553
127regulation of germinal center formation (GO:0002634)2.43866273
128regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41679580
129cytokine biosynthetic process (GO:0042089)2.40706171
130positive regulation of B cell differentiation (GO:0045579)2.40534771
131neutrophil activation (GO:0042119)2.40412198
132positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.40272710
133regulation of leukocyte mediated cytotoxicity (GO:0001910)2.38874890
134regulation of alpha-beta T cell proliferation (GO:0046640)2.38614958
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.38384219
136regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.37729448
137mitotic chromosome condensation (GO:0007076)2.37714093
138meiotic chromosome segregation (GO:0045132)2.37656930
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36812231
140response to host (GO:0075136)2.36812231
141response to host defenses (GO:0052200)2.36812231
142G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.36667570
143I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.36654967
144neural tube formation (GO:0001841)2.36495420
145negative regulation of lymphocyte mediated immunity (GO:0002707)2.36188216
146positive regulation of calcium-mediated signaling (GO:0050850)2.36116860
147regulation of gamma-delta T cell differentiation (GO:0045586)2.35784035
148regulation of hypersensitivity (GO:0002883)2.35534525
149mature B cell differentiation (GO:0002335)2.35052773
150regulation of B cell receptor signaling pathway (GO:0050855)2.33950017
151positive regulation of interleukin-17 production (GO:0032740)2.33850448
152defense response to protozoan (GO:0042832)2.33750611
153positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.33676121
154mitotic metaphase plate congression (GO:0007080)2.32801884
155lymphocyte mediated immunity (GO:0002449)2.32547577
156pore complex assembly (GO:0046931)2.32305148
157macrophage activation involved in immune response (GO:0002281)2.31460352
158positive regulation of toll-like receptor signaling pathway (GO:0034123)2.31376027
159regulation of helicase activity (GO:0051095)2.31200838
160leukocyte aggregation (GO:0070486)2.30432543
161protein localization to chromosome, centromeric region (GO:0071459)2.30096314
162response to interferon-beta (GO:0035456)2.28897009
163protein localization to kinetochore (GO:0034501)2.28838385
164regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.28565149
165regulation of T-helper 1 cell differentiation (GO:0045625)2.26971120
166cellular response to dsRNA (GO:0071359)2.26443190
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.25369778
168positive regulation of type I interferon production (GO:0032481)2.25330131
169cell killing (GO:0001906)2.24351680
170production of molecular mediator involved in inflammatory response (GO:0002532)2.24214214
171negative regulation of myeloid cell apoptotic process (GO:0033033)2.24054037
172kinetochore organization (GO:0051383)2.23554895
173regulation of B cell differentiation (GO:0045577)2.23037320
174positive regulation of interleukin-12 production (GO:0032735)2.22315956
175positive regulation of protein import into nucleus, translocation (GO:0033160)2.21682280
176lipopolysaccharide-mediated signaling pathway (GO:0031663)2.21187845
177telomere maintenance via recombination (GO:0000722)2.21054350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14276436
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.51973523
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.35282373
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.90097505
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.78873987
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.92777285
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.74469061
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63343302
9GATA1_22025678_ChIP-Seq_K562_Human2.57908977
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55703066
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.49395785
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.45681646
13IGF1R_20145208_ChIP-Seq_DFB_Human2.45174973
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.34813238
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33783361
16ZNF274_21170338_ChIP-Seq_K562_Hela2.27815540
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.22883321
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20784484
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18806138
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15617323
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10577342
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.09457511
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09390488
24VDR_22108803_ChIP-Seq_LS180_Human2.07524801
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06703635
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04374414
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97374177
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96575163
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89510686
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88617167
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82491232
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78926739
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77257098
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72419377
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71381102
36* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68582930
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.63886070
38* SPI1_23547873_ChIP-Seq_NB4_Human1.62020548
39MYB_26560356_Chip-Seq_TH2_Human1.61822900
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60362532
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60019134
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.59115522
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54328580
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51775587
45* MYB_26560356_Chip-Seq_TH1_Human1.51652629
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50940730
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.50899615
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48223882
49AR_21909140_ChIP-Seq_LNCAP_Human1.47682386
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46322180
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45890844
52VDR_24787735_ChIP-Seq_THP-1_Human1.44822467
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44002352
54ER_23166858_ChIP-Seq_MCF-7_Human1.41831230
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41312288
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40445028
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39994593
58VDR_23849224_ChIP-Seq_CD4+_Human1.37980972
59MAF_26560356_Chip-Seq_TH1_Human1.37361871
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34088637
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.34076065
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33905275
63MYC_22102868_ChIP-Seq_BL_Human1.33579182
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33495161
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32617714
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31686364
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.29941827
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29397386
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29305401
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.29126962
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29078797
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27636236
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23505996
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.22941924
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22544426
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22018403
77TAF15_26573619_Chip-Seq_HEK293_Human1.21089403
78* EST1_17652178_ChIP-ChIP_JURKAT_Human1.19631121
79TP53_22573176_ChIP-Seq_HFKS_Human1.18718577
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18515912
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.17191741
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16906673
83* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16629729
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15458247
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.15230484
86* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14775723
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14167854
88EWS_26573619_Chip-Seq_HEK293_Human1.14136035
89GBX2_23144817_ChIP-Seq_PC3_Human1.14036273
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.13948239
91ELK1_19687146_ChIP-ChIP_HELA_Human1.13700530
92BCAT_22108803_ChIP-Seq_LS180_Human1.13321044
93FOXP3_21729870_ChIP-Seq_TREG_Human1.13118549
94PU_27001747_Chip-Seq_BMDM_Mouse1.12517249
95FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12124744
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11700165
97* VDR_21846776_ChIP-Seq_THP-1_Human1.11370454
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.10916297
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10450086
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09293930
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09187189
102SMRT_27268052_Chip-Seq_Bcells_Human1.09029771
103CBP_20019798_ChIP-Seq_JUKART_Human1.08234461
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08234461
105UTX_26944678_Chip-Seq_JUKART_Human1.06954635
106CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06049271
107CIITA_25753668_ChIP-Seq_RAJI_Human1.05946366
108IRF1_19129219_ChIP-ChIP_H3396_Human1.05337111
109P300_19829295_ChIP-Seq_ESCs_Human1.04912916
110GATA3_27048872_Chip-Seq_THYMUS_Human1.04808699
111MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04673266
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04408537
113TCF4_23295773_ChIP-Seq_U87_Human1.04073414
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03652838
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03416363
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03403969
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03035415
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.02908418
119FUS_26573619_Chip-Seq_HEK293_Human1.02722024
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02593318
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.02593318
122* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01604650
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01182680
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00776881
125STAT3_23295773_ChIP-Seq_U87_Human1.00186952
126GATA3_26560356_Chip-Seq_TH1_Human0.99686285
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98704542
128TFEB_21752829_ChIP-Seq_HELA_Human0.98487583
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98288251
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98251272
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98036457
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.97951074
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97710250
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97630239
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97226894
136GATA3_26560356_Chip-Seq_TH2_Human0.96668080
137DCP1A_22483619_ChIP-Seq_HELA_Human0.96306662
138SPI1_23127762_ChIP-Seq_K562_Human0.95851666
139SOX2_19829295_ChIP-Seq_ESCs_Human0.94850367
140NANOG_19829295_ChIP-Seq_ESCs_Human0.94850367
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.94375072
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93848933
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.93844172
144SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93708923
145SCL_19346495_ChIP-Seq_HPC-7_Human0.93304277
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93215894
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.92870193
148EZH2_22144423_ChIP-Seq_EOC_Human0.92559915
149JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92537029
150AR_20517297_ChIP-Seq_VCAP_Human0.92492273
151MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91526956
152* VDR_24763502_ChIP-Seq_THP-1_Human0.89457598
153MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88953201
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88054308
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88030371
156KDM5A_27292631_Chip-Seq_BREAST_Human0.87787217
157MAF_26560356_Chip-Seq_TH2_Human0.87047931
158MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86775485
159CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86417483
160MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86104145
161GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85688449
162NOTCH1_21737748_ChIP-Seq_TLL_Human0.85676208
163RUNX_20019798_ChIP-Seq_JUKART_Human0.83216719
164KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82916184
165MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82344654
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81452312
167CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80775082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.74915611
2MP0009785_altered_susceptibility_to3.02587618
3MP0008057_abnormal_DNA_replication2.61518401
4MP0003436_decreased_susceptibility_to2.59604181
5MP0000685_abnormal_immune_system2.51912582
6MP0001800_abnormal_humoral_immune2.47150496
7MP0003787_abnormal_imprinting2.40431777
8MP0001790_abnormal_immune_system2.37781203
9MP0005387_immune_system_phenotype2.37781203
10MP0005360_urolithiasis2.36291347
11MP0005000_abnormal_immune_tolerance2.34955199
12MP0005025_abnormal_response_to2.34715300
13MP0006082_CNS_inflammation2.32243766
14MP0002139_abnormal_hepatobiliary_system2.32033768
15MP0002148_abnormal_hypersensitivity_rea2.25429751
16MP0005671_abnormal_response_to2.24110225
17MP0005075_abnormal_melanosome_morpholog2.22911539
18MP0002452_abnormal_antigen_presenting2.19872413
19MP0002723_abnormal_immune_serum2.17099183
20MP0002419_abnormal_innate_immunity2.13154985
21MP0000372_irregular_coat_pigmentation2.11447261
22MP0005174_abnormal_tail_pigmentation2.06565948
23MP0003693_abnormal_embryo_hatching2.06562188
24MP0003724_increased_susceptibility_to2.05025051
25MP0010094_abnormal_chromosome_stability1.99218556
26MP0000015_abnormal_ear_pigmentation1.94432931
27MP0002166_altered_tumor_susceptibility1.93542761
28MP0001819_abnormal_immune_cell1.92354931
29MP0003763_abnormal_thymus_physiology1.92071410
30MP0002006_tumorigenesis1.90502830
31MP0002420_abnormal_adaptive_immunity1.90494745
32MP0010307_abnormal_tumor_latency1.88385298
33MP0003303_peritoneal_inflammation1.84832063
34MP0009333_abnormal_splenocyte_physiolog1.81478829
35MP0002398_abnormal_bone_marrow1.79012506
36MP0001853_heart_inflammation1.78472862
37MP0001986_abnormal_taste_sensitivity1.71956139
38MP0009840_abnormal_foam_cell1.71937782
39MP0003077_abnormal_cell_cycle1.71752263
40MP0000716_abnormal_immune_system1.67144419
41MP0003111_abnormal_nucleus_morphology1.66385201
42MP0002396_abnormal_hematopoietic_system1.65191872
43MP0004947_skin_inflammation1.60303601
44MP0004510_myositis1.59231392
45MP0005365_abnormal_bile_salt1.57252268
46MP0009764_decreased_sensitivity_to1.56616507
47MP0005464_abnormal_platelet_physiology1.55915469
48MP0001845_abnormal_inflammatory_respons1.54134378
49MP0003195_calcinosis1.53648814
50MP0000689_abnormal_spleen_morphology1.53293755
51MP0008469_abnormal_protein_level1.52586591
52MP0002405_respiratory_system_inflammati1.51700407
53MP0010155_abnormal_intestine_physiology1.49168299
54MP0003806_abnormal_nucleotide_metabolis1.48912185
55MP0008058_abnormal_DNA_repair1.45026308
56MP0002009_preneoplasia1.44641070
57MP0002429_abnormal_blood_cell1.43966386
58MP0002722_abnormal_immune_system1.43463717
59MP0005085_abnormal_gallbladder_physiolo1.42558885
60MP0010352_gastrointestinal_tract_polyps1.39610526
61MP0001545_abnormal_hematopoietic_system1.38022675
62MP0005397_hematopoietic_system_phenotyp1.38022675
63MP0000465_gastrointestinal_hemorrhage1.34833459
64MP0004147_increased_porphyrin_level1.31371273
65MP0003191_abnormal_cellular_cholesterol1.25368994
66MP0002138_abnormal_hepatobiliary_system1.22220248
67MP0008875_abnormal_xenobiotic_pharmacok1.21775756
68MP0009763_increased_sensitivity_to1.21332516
69MP0004957_abnormal_blastocyst_morpholog1.21263329
70MP0008007_abnormal_cellular_replicative1.20910349
71MP0001533_abnormal_skeleton_physiology1.19353233
72MP0003866_abnormal_defecation1.18471931
73MP0003448_altered_tumor_morphology1.17719268
74MP0003656_abnormal_erythrocyte_physiolo1.17091559
75MP0005646_abnormal_pituitary_gland1.16753269
76MP0002095_abnormal_skin_pigmentation1.16138787
77MP0005084_abnormal_gallbladder_morpholo1.14820446
78MP0000609_abnormal_liver_physiology1.14370595
79MP0000858_altered_metastatic_potential1.12593221
80MP0003300_gastrointestinal_ulcer1.11550952
81MP0005451_abnormal_body_composition1.10533973
82MP0003252_abnormal_bile_duct1.09932623
83MP0004808_abnormal_hematopoietic_stem1.09498612
84MP0003646_muscle_fatigue1.09402071
85MP0000703_abnormal_thymus_morphology1.06803299
86MP0002019_abnormal_tumor_incidence1.05642466
87MP0003186_abnormal_redox_activity1.02743578
88MP0005058_abnormal_lysosome_morphology1.01610166
89MP0005310_abnormal_salivary_gland1.01122322
90MP0000490_abnormal_crypts_of1.00792870
91MP0002837_dystrophic_cardiac_calcinosis0.97843641
92MP0004381_abnormal_hair_follicle0.97717095
93MP0003121_genomic_imprinting0.97258981
94MP0003011_delayed_dark_adaptation0.96360936
95MP0008872_abnormal_physiological_respon0.94350134
96MP0004043_abnormal_pH_regulation0.89738403
97MP0005076_abnormal_cell_differentiation0.89647747
98MP0005645_abnormal_hypothalamus_physiol0.87245718
99MP0005253_abnormal_eye_physiology0.86436958
100MP0008877_abnormal_DNA_methylation0.85501289
101MP0000598_abnormal_liver_morphology0.84613623
102MP0000350_abnormal_cell_proliferation0.83862843
103MP0009278_abnormal_bone_marrow0.83422117
104MP0001873_stomach_inflammation0.83033214
105MP0002638_abnormal_pupillary_reflex0.82648911
106MP0005551_abnormal_eye_electrophysiolog0.82262581
107MP0003718_maternal_effect0.82240996
108MP0010386_abnormal_urinary_bladder0.81697925
109MP0005319_abnormal_enzyme/_coenzyme0.80957098
110MP0000569_abnormal_digit_pigmentation0.80870172
111MP0002693_abnormal_pancreas_physiology0.79673111
112MP0009765_abnormal_xenobiotic_induced0.79490447
113MP0006072_abnormal_retinal_apoptosis0.77864259
114MP0003453_abnormal_keratinocyte_physiol0.77725213
115MP0002933_joint_inflammation0.75197259
116MP0000313_abnormal_cell_death0.74143743
117MP0001915_intracranial_hemorrhage0.72550295
118MP0005083_abnormal_biliary_tract0.72285211
119MP0001663_abnormal_digestive_system0.72060358
120MP0005408_hypopigmentation0.71386450
121MP0005389_reproductive_system_phenotype0.70469231
122MP0000371_diluted_coat_color0.69718063
123MP0004130_abnormal_muscle_cell0.68577293
124MP0003183_abnormal_peptide_metabolism0.68406323
125MP0005167_abnormal_blood-brain_barrier0.68080236
126MP0004484_altered_response_of0.68077766
127MP0008995_early_reproductive_senescence0.66289007
128MP0002928_abnormal_bile_duct0.66056934
129MP0005023_abnormal_wound_healing0.65864559
130MP0000604_amyloidosis0.65613741
131MP0002136_abnormal_kidney_physiology0.65030562
132MP0005171_absent_coat_pigmentation0.64679764
133MP0003172_abnormal_lysosome_physiology0.64637694
134MP0001764_abnormal_homeostasis0.63516179
135MP0010329_abnormal_lipoprotein_level0.63414826
136MP0008260_abnormal_autophagy0.62664678
137MP0005621_abnormal_cell_physiology0.60372454
138MP0001119_abnormal_female_reproductive0.60347948

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.45489880
2Recurrent abscess formation (HP:0002722)4.37429431
3Eczematoid dermatitis (HP:0000976)4.31438070
4Recurrent gram-negative bacterial infections (HP:0005420)4.22594821
5Autoimmune thrombocytopenia (HP:0001973)3.82301714
6Recurrent viral infections (HP:0004429)3.80476162
7Mediastinal lymphadenopathy (HP:0100721)3.47351705
8Recurrent fungal infections (HP:0002841)3.44090568
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.41981520
10Abnormality of B cell number (HP:0010975)3.38668849
11Vasculitis (HP:0002633)3.23852819
12Elevated erythrocyte sedimentation rate (HP:0003565)3.23325345
13Chronic otitis media (HP:0000389)3.23053424
14Recurrent skin infections (HP:0001581)3.17683206
15Congenital stationary night blindness (HP:0007642)2.97788018
16Abnormal rod and cone electroretinograms (HP:0008323)2.96907281
17Periodontitis (HP:0000704)2.96387416
18Thyroiditis (HP:0100646)2.95091996
19Abnormality of macrophages (HP:0004311)2.94431428
20Pustule (HP:0200039)2.93885773
21Myocardial infarction (HP:0001658)2.92023846
22Gingival bleeding (HP:0000225)2.85167732
23B lymphocytopenia (HP:0010976)2.82961763
24Myositis (HP:0100614)2.82781933
25Recurrent bronchitis (HP:0002837)2.81985530
26Abnormality of T cell number (HP:0011839)2.75285003
27Prostate neoplasm (HP:0100787)2.75003253
28Constricted visual fields (HP:0001133)2.73363996
29Abnormality of the renal cortex (HP:0011035)2.71354263
30Attenuation of retinal blood vessels (HP:0007843)2.68234359
31Stomatitis (HP:0010280)2.65931190
32Renal cortical cysts (HP:0000803)2.65791450
33T lymphocytopenia (HP:0005403)2.65567384
34Retrobulbar optic neuritis (HP:0100654)2.63915282
35Optic neuritis (HP:0100653)2.63915282
36Recurrent cutaneous fungal infections (HP:0011370)2.62991125
37Chronic mucocutaneous candidiasis (HP:0002728)2.62991125
38Abnormality of glycolipid metabolism (HP:0010969)2.61973757
39Abnormality of liposaccharide metabolism (HP:0010968)2.61973757
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.61973757
41Orchitis (HP:0100796)2.60282201
42Abnormality of the prostate (HP:0008775)2.59029996
43Gastrointestinal infarctions (HP:0005244)2.59016407
44Gingivitis (HP:0000230)2.58720342
45Abnormality of pyrimidine metabolism (HP:0004353)2.52416753
46Birth length less than 3rd percentile (HP:0003561)2.52075499
47Nasal polyposis (HP:0100582)2.51307616
48Abnormality of T cells (HP:0002843)2.51298986
49Systemic lupus erythematosus (HP:0002725)2.49892026
50Basal ganglia calcification (HP:0002135)2.48340067
51Eosinophilia (HP:0001880)2.47118442
52Chronic diarrhea (HP:0002028)2.46971967
53Leukocytosis (HP:0001974)2.46672926
54Genetic anticipation (HP:0003743)2.46513755
55Chromsome breakage (HP:0040012)2.45408709
56Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41404366
57Pulmonary infiltrates (HP:0002113)2.41154900
58Pancreatic cysts (HP:0001737)2.41083575
59Intrahepatic cholestasis (HP:0001406)2.40518771
60Thrombocytosis (HP:0001894)2.38358465
61Joint hemorrhage (HP:0005261)2.37542682
62Abnormality of T cell physiology (HP:0011840)2.37018577
63Combined immunodeficiency (HP:0005387)2.36488156
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36160674
65Spontaneous hematomas (HP:0007420)2.35413347
66Lymphopenia (HP:0001888)2.35270614
67Obstructive lung disease (HP:0006536)2.35206557
68Chronic obstructive pulmonary disease (HP:0006510)2.35206557
69Prolonged partial thromboplastin time (HP:0003645)2.34805208
70Increased IgM level (HP:0003496)2.34451412
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.33684807
72Granulocytopenia (HP:0001913)2.32801313
73IgG deficiency (HP:0004315)2.27836871
74Gaze-evoked nystagmus (HP:0000640)2.25441039
75Abnormality of the fingertips (HP:0001211)2.25213750
76IgA deficiency (HP:0002720)2.23804250
77Hematochezia (HP:0002573)2.23536951
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.23327955
79Osteolytic defects of the hand bones (HP:0009699)2.23327955
80Meningitis (HP:0001287)2.22122671
81Abolished electroretinogram (ERG) (HP:0000550)2.20195070
82Anorexia (HP:0002039)2.20108249
83Stomach cancer (HP:0012126)2.19954288
84Hypobetalipoproteinemia (HP:0003563)2.19901038
85Abnormality of eosinophils (HP:0001879)2.19881429
86Deep venous thrombosis (HP:0002625)2.19179945
87Hypergammaglobulinemia (HP:0010702)2.17531750
88Cellulitis (HP:0100658)2.16911667
89Increased neuronal autofluorescent lipopigment (HP:0002074)2.16143050
90Encephalitis (HP:0002383)2.15851781
91Severe combined immunodeficiency (HP:0004430)2.14226371
92Amyotrophic lateral sclerosis (HP:0007354)2.13057046
93Vacuolated lymphocytes (HP:0001922)2.12505433
94Xanthomatosis (HP:0000991)2.12184287
95Abnormal drinking behavior (HP:0030082)2.10793004
96Polydipsia (HP:0001959)2.10793004
97Autoimmune hemolytic anemia (HP:0001890)2.09774418
98Increased cerebral lipofuscin (HP:0011813)2.09192825
99Leukopenia (HP:0001882)2.08813433
100Osteomyelitis (HP:0002754)2.07891466
101Abnormality of male internal genitalia (HP:0000022)2.07577895
102Lymphoma (HP:0002665)2.07309712
103Hypoproteinemia (HP:0003075)2.07180201
104Complement deficiency (HP:0004431)2.05475245
105Hypoplasia of the thymus (HP:0000778)2.05329428
106Abnormal delayed hypersensitivity skin test (HP:0002963)2.03119224
107Recurrent pneumonia (HP:0006532)2.02139203
108Abnormality of midbrain morphology (HP:0002418)2.02134922
109Molar tooth sign on MRI (HP:0002419)2.02134922
110Chronic hepatic failure (HP:0100626)2.02003128
111Clumsiness (HP:0002312)2.01842634
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01635095
113IgM deficiency (HP:0002850)2.01214034
114Agammaglobulinemia (HP:0004432)2.01105790
115Arterial thrombosis (HP:0004420)1.99867987
116Joint swelling (HP:0001386)1.99267817
117Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98645031
118Keratoconjunctivitis sicca (HP:0001097)1.98128218
119Fair hair (HP:0002286)1.96429153
120Abnormality of the nasal mucosa (HP:0000433)1.96226373
121Recurrent sinusitis (HP:0011108)1.95828471
122Abnormality of sulfur amino acid metabolism (HP:0004339)1.94292815
123Abnormality of the common coagulation pathway (HP:0010990)1.93948017
124Epistaxis (HP:0000421)1.92833347
125Nausea (HP:0002018)1.92068691
126Inflammation of the large intestine (HP:0002037)1.92050906
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.91864069
128Absent/shortened dynein arms (HP:0200106)1.91864069
129Panhypogammaglobulinemia (HP:0003139)1.91024899
130Gastrointestinal stroma tumor (HP:0100723)1.90974743
131Urticaria (HP:0001025)1.89233343
132Prolonged bleeding time (HP:0003010)1.89017480
133Nephronophthisis (HP:0000090)1.88370589
134Acute myeloid leukemia (HP:0004808)1.87837406
135Recurrent lower respiratory tract infections (HP:0002783)1.87205562
136Pancreatic fibrosis (HP:0100732)1.87197725
137Hemoptysis (HP:0002105)1.87189847
138Emphysema (HP:0002097)1.86969244
139Abnormality of chromosome stability (HP:0003220)1.86558194
140Generalized hypopigmentation of hair (HP:0011358)1.85982827
141Acute lymphatic leukemia (HP:0006721)1.85697090
142Neurodegeneration (HP:0002180)1.84872866
143Agnosia (HP:0010524)1.84264365
144Colitis (HP:0002583)1.84161119
145Abnormality of the renal medulla (HP:0100957)1.83816304
146Progressive cerebellar ataxia (HP:0002073)1.83161299
147Chest pain (HP:0100749)1.82833198
148Gonadal dysgenesis (HP:0000133)1.82776356
149Widely spaced teeth (HP:0000687)1.82346408
150Abnormal biliary tract physiology (HP:0012439)1.82188501
151Bile duct proliferation (HP:0001408)1.82188501
152Pulmonary embolism (HP:0002204)1.81508706
153True hermaphroditism (HP:0010459)1.81215081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.80198726
2FRK3.64983892
3MAP3K143.29746546
4MAP4K12.88675246
5JAK32.86549208
6IKBKE2.53031374
7JAK12.40966001
8IRAK42.31673818
9CDC72.28699486
10MAP3K132.22788286
11TBK12.10339260
12NEK22.08762928
13FGFR42.05151246
14BLK2.00454342
15TXK1.91493225
16IKBKB1.91391886
17PLK41.90058729
18PBK1.89861866
19KIT1.81642608
20ADRBK21.80314816
21CDK191.78545655
22TLK11.74378894
23RPS6KA41.72775622
24ACVR1B1.71536219
25ERN11.69593790
26IRAK31.68180212
27STK41.65205169
28EIF2AK11.63685096
29CDK121.63096713
30FES1.63080515
31TAOK31.62344318
32STK101.59081410
33TNK21.57041100
34BUB11.55260675
35STK31.51241550
36CHUK1.49879751
37MAP4K21.46793093
38PIK3CG1.43154302
39RIPK41.42358654
40PINK11.38984258
41CAMKK21.33065704
42PIM11.32818957
43ZAK1.31805089
44GRK71.27213540
45CSK1.26078335
46WEE11.24522123
47OXSR11.19736268
48CDK41.16959959
49DAPK21.15435065
50EIF2AK21.12815564
51ATR1.11148578
52BTK1.10775224
53GRK11.08976029
54CSF1R1.08809740
55PIM21.04902689
56ZAP701.03357379
57NEK91.03290295
58EIF2AK31.01838966
59BMPR1B1.01297533
60FGFR30.99845790
61MAP2K60.98930509
62LATS10.97945585
63MAP2K30.95907925
64SYK0.95766808
65MAP3K100.93037561
66WNK30.93002652
67LCK0.91653968
68AURKB0.89410580
69SIK20.89250180
70MAPK110.88924319
71JAK20.88209495
72BRSK20.88174617
73NUAK10.87936236
74LYN0.86814621
75MAP3K50.86310609
76STK240.86017217
77CDK60.85937972
78TEC0.83606652
79MAPK130.80156901
80SRPK10.79933237
81NEK10.79924064
82RPS6KA50.78061278
83EPHB10.77495092
84TGFBR20.74926301
85PLK10.74794570
86PRPF4B0.73983514
87HCK0.73931815
88EPHA30.73277436
89MARK30.71382909
90FLT30.68852930
91MAP3K80.67663976
92DYRK30.67454944
93SCYL20.66655595
94TESK20.66386862
95MAP3K40.64131291
96CHEK10.61944463
97PDK10.61841933
98RPS6KA60.61233133
99GRK60.61100320
100CHEK20.61018086
101ITK0.60607330
102VRK10.60105550
103MST40.56761564
104MST1R0.56376553
105TTK0.56376406
106ATM0.56374655
107MAP3K60.55634708
108SGK20.54250884
109STK110.53844229
110KDR0.51848210
111LRRK20.50840279
112PRKCQ0.50810630
113TRPM70.50777804
114ERBB40.50577782
115ABL20.50483407
116TGFBR10.50312359
117AKT30.49826712
118IRAK10.47878248
119MELK0.47841256
120MAPK70.47389410
121ADRBK10.46969989
122ABL10.46900772
123MAP3K70.45973601
124RPS6KL10.45740933
125RPS6KC10.45740933
126CDK70.45691815
127BRD40.44220098
128HIPK20.42956252
129ERBB30.42572399
130WNK40.41969692
131NME20.41964186
132BMPR20.41899234
133ARAF0.41601156
134MAPK120.40338376
135PRKAA20.39922426
136IGF1R0.39710047
137PIK3CA0.39224527
138CAMKK10.36736245
139MATK0.36667951
140NLK0.34952570
141RPS6KB10.33542772
142CAMK1D0.33075412
143CDK20.32848099
144YES10.32218386
145CDK30.31646534
146PASK0.31160753
147PTK2B0.31071224
148INSRR0.30385385
149EGFR0.26292646

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.65822057
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.40670891
3DNA replication_Homo sapiens_hsa030302.28599612
4Measles_Homo sapiens_hsa051622.21093603
5Staphylococcus aureus infection_Homo sapiens_hsa051502.15858582
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.13674577
7Caffeine metabolism_Homo sapiens_hsa002322.12294119
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.11474993
9Leishmaniasis_Homo sapiens_hsa051402.08783900
10Herpes simplex infection_Homo sapiens_hsa051682.03689246
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.96653802
12One carbon pool by folate_Homo sapiens_hsa006701.95543366
13Graft-versus-host disease_Homo sapiens_hsa053321.91355106
14Primary immunodeficiency_Homo sapiens_hsa053401.89386818
15Allograft rejection_Homo sapiens_hsa053301.82525970
16Influenza A_Homo sapiens_hsa051641.76856539
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73392292
18Linoleic acid metabolism_Homo sapiens_hsa005911.66298695
19Legionellosis_Homo sapiens_hsa051341.64147354
20Antigen processing and presentation_Homo sapiens_hsa046121.62653564
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60533603
22Homologous recombination_Homo sapiens_hsa034401.58651884
23Mismatch repair_Homo sapiens_hsa034301.57561313
24Other glycan degradation_Homo sapiens_hsa005111.55894903
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50024032
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48535117
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45865039
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45009077
29Complement and coagulation cascades_Homo sapiens_hsa046101.39792482
30Ether lipid metabolism_Homo sapiens_hsa005651.38349730
31Base excision repair_Homo sapiens_hsa034101.29710485
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28449617
33Osteoclast differentiation_Homo sapiens_hsa043801.26211705
34Malaria_Homo sapiens_hsa051441.25076507
35TNF signaling pathway_Homo sapiens_hsa046681.23592255
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21552867
37Lysosome_Homo sapiens_hsa041421.20501647
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19615018
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.19045161
40B cell receptor signaling pathway_Homo sapiens_hsa046621.16327977
41p53 signaling pathway_Homo sapiens_hsa041151.15914434
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15872951
43Cell cycle_Homo sapiens_hsa041101.14419927
44Apoptosis_Homo sapiens_hsa042101.13352725
45Systemic lupus erythematosus_Homo sapiens_hsa053221.10533922
46Selenocompound metabolism_Homo sapiens_hsa004501.09199604
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.08721853
48Platelet activation_Homo sapiens_hsa046111.07800168
49Regulation of autophagy_Homo sapiens_hsa041401.06897709
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05981031
51Pyrimidine metabolism_Homo sapiens_hsa002401.05158112
52Non-homologous end-joining_Homo sapiens_hsa034501.04063397
53Tuberculosis_Homo sapiens_hsa051521.03101267
54Toxoplasmosis_Homo sapiens_hsa051451.03008782
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02524187
56Asthma_Homo sapiens_hsa053101.02443912
57Hematopoietic cell lineage_Homo sapiens_hsa046401.02415952
58Fanconi anemia pathway_Homo sapiens_hsa034601.02154901
59Proteasome_Homo sapiens_hsa030501.01581924
60Pertussis_Homo sapiens_hsa051331.01144249
61Hepatitis C_Homo sapiens_hsa051601.00167940
62Hepatitis B_Homo sapiens_hsa051610.97086896
63Epstein-Barr virus infection_Homo sapiens_hsa051690.93523139
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93472924
65Phototransduction_Homo sapiens_hsa047440.92630334
66RNA transport_Homo sapiens_hsa030130.90966063
67Vitamin B6 metabolism_Homo sapiens_hsa007500.89688035
68Folate biosynthesis_Homo sapiens_hsa007900.88167165
69Nucleotide excision repair_Homo sapiens_hsa034200.87009314
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86257713
71Viral carcinogenesis_Homo sapiens_hsa052030.85723405
72Pentose phosphate pathway_Homo sapiens_hsa000300.85582657
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84946446
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84567246
75Arachidonic acid metabolism_Homo sapiens_hsa005900.83370578
76Arginine biosynthesis_Homo sapiens_hsa002200.82058636
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81774179
78Dorso-ventral axis formation_Homo sapiens_hsa043200.81580030
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80069056
80Tryptophan metabolism_Homo sapiens_hsa003800.79945177
81RNA polymerase_Homo sapiens_hsa030200.78837121
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76950292
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76909242
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76706928
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75365341
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75334810
87Spliceosome_Homo sapiens_hsa030400.74414719
88Autoimmune thyroid disease_Homo sapiens_hsa053200.73983760
89Phagosome_Homo sapiens_hsa041450.73982442
90Nitrogen metabolism_Homo sapiens_hsa009100.73724717
91RNA degradation_Homo sapiens_hsa030180.73100478
92T cell receptor signaling pathway_Homo sapiens_hsa046600.72998583
93ABC transporters_Homo sapiens_hsa020100.71401784
94Viral myocarditis_Homo sapiens_hsa054160.69184015
95Basal transcription factors_Homo sapiens_hsa030220.67256095
96Peroxisome_Homo sapiens_hsa041460.66589465
97Type I diabetes mellitus_Homo sapiens_hsa049400.65728794
98Small cell lung cancer_Homo sapiens_hsa052220.62785427
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61943346
100Chemokine signaling pathway_Homo sapiens_hsa040620.61706806
101Shigellosis_Homo sapiens_hsa051310.60219454
102African trypanosomiasis_Homo sapiens_hsa051430.59221066
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.58196431
104Olfactory transduction_Homo sapiens_hsa047400.57386748
105Chemical carcinogenesis_Homo sapiens_hsa052040.55351092
106Steroid biosynthesis_Homo sapiens_hsa001000.54404542
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51376111
108Fatty acid degradation_Homo sapiens_hsa000710.51230149
109Ovarian steroidogenesis_Homo sapiens_hsa049130.50476617
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49853679
111Histidine metabolism_Homo sapiens_hsa003400.48571117
112Rheumatoid arthritis_Homo sapiens_hsa053230.47062273
113Butanoate metabolism_Homo sapiens_hsa006500.46836797
114Retinol metabolism_Homo sapiens_hsa008300.46280207
115Collecting duct acid secretion_Homo sapiens_hsa049660.46045889
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.45757937
117HTLV-I infection_Homo sapiens_hsa051660.45051769
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.44729736
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43502892
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42877121
121beta-Alanine metabolism_Homo sapiens_hsa004100.41794668
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40765889
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40551868
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40495212
125Salivary secretion_Homo sapiens_hsa049700.40454784
126Salmonella infection_Homo sapiens_hsa051320.39064882
127mTOR signaling pathway_Homo sapiens_hsa041500.38664936
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38367242
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.37351959
130Acute myeloid leukemia_Homo sapiens_hsa052210.36746825
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33035109
132Inositol phosphate metabolism_Homo sapiens_hsa005620.31539418
133Taste transduction_Homo sapiens_hsa047420.27295069
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.24218470
135Renin secretion_Homo sapiens_hsa049240.21666975
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.20732921
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20688061
138Morphine addiction_Homo sapiens_hsa050320.20509088
139Serotonergic synapse_Homo sapiens_hsa047260.20422114

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