ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H2A acetylation (GO:0043968)	7.67411977
2	synapsis (GO:0007129)	5.00740723
3	resolution of meiotic recombination intermediates (GO:0000712)	4.99077891
4	DNA strand renaturation (GO:0000733)	4.67348861
5	chromatin remodeling at centromere (GO:0031055)	4.47426193
6	centriole replication (GO:0007099)	4.44723202
7	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.41347871
8	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.41347871
9	CENP-A containing nucleosome assembly (GO:0034080)	4.40223153
10	negative regulation of axon guidance (GO:1902668)	4.19435782
11	DNA replication-dependent nucleosome organization (GO:0034723)	4.16637602
12	DNA replication-dependent nucleosome assembly (GO:0006335)	4.16637602
13	protein heterotetramerization (GO:0051290)	4.12513221
14	histone exchange (GO:0043486)	4.00996646
15	negative regulation of DNA recombination (GO:0045910)	3.94363675
16	pyrimidine dimer repair (GO:0006290)	3.79913886
17	DNA replication checkpoint (GO:0000076)	3.78848771
18	regulation of helicase activity (GO:0051095)	3.68843219
19	postreplication repair (GO:0006301)	3.67854491
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63953784
21	DNA methylation involved in gamete generation (GO:0043046)	3.63022553
22	regulation of centriole replication (GO:0046599)	3.60813392
23	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.58223941
24	regulation of translation, ncRNA-mediated (GO:0045974)	3.58223941
25	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.58223941
26	DNA double-strand break processing (GO:0000729)	3.56884967
27	regulation of DNA endoreduplication (GO:0032875)	3.44232377
28	transmission of nerve impulse (GO:0019226)	3.43529238
29	DNA replication-independent nucleosome assembly (GO:0006336)	3.41651147
30	DNA replication-independent nucleosome organization (GO:0034724)	3.41651147
31	intraciliary transport (GO:0042073)	3.39556129
32	vocalization behavior (GO:0071625)	3.36931079
33	double-strand break repair via homologous recombination (GO:0000724)	3.33854689
34	presynaptic membrane assembly (GO:0097105)	3.32348663
35	regulation of meiosis I (GO:0060631)	3.31705065
36	replication fork processing (GO:0031297)	3.31337675
37	translesion synthesis (GO:0019985)	3.30086906
38	recombinational repair (GO:0000725)	3.29694790
39	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.27930611
40	piRNA metabolic process (GO:0034587)	3.26659326
41	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.25905325
42	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.25905325
43	isotype switching (GO:0045190)	3.25905325
44	neuronal ion channel clustering (GO:0045161)	3.19420214
45	postsynaptic membrane organization (GO:0001941)	3.18999577
46	response to X-ray (GO:0010165)	3.16715307
47	telomere maintenance via semi-conservative replication (GO:0032201)	3.12728741
48	DNA strand elongation involved in DNA replication (GO:0006271)	3.12645792
49	gamma-aminobutyric acid transport (GO:0015812)	3.05825159
50	sister chromatid segregation (GO:0000819)	3.03486420
51	non-recombinational repair (GO:0000726)	3.02743607
52	double-strand break repair via nonhomologous end joining (GO:0006303)	3.02743607
53	telomere maintenance via recombination (GO:0000722)	3.01377619
54	DNA strand elongation (GO:0022616)	2.97551459
55	mitotic sister chromatid segregation (GO:0000070)	2.96640978
56	mitotic recombination (GO:0006312)	2.94128951
57	striatum development (GO:0021756)	2.92594444
58	protein localization to cilium (GO:0061512)	2.92552108
59	pyrimidine nucleobase catabolic process (GO:0006208)	2.92333899
60	DNA catabolic process, exonucleolytic (GO:0000738)	2.90479764
61	epithelial cilium movement (GO:0003351)	2.88315970
62	attachment of spindle microtubules to kinetochore (GO:0008608)	2.87798000
63	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.87632428
64	DNA integration (GO:0015074)	2.81431354
65	photoreceptor cell maintenance (GO:0045494)	2.80987006
66	positive regulation of mitochondrial fission (GO:0090141)	2.80902262
67	lactate metabolic process (GO:0006089)	2.80391970
68	meiotic chromosome segregation (GO:0045132)	2.78701562
69	mitochondrial DNA replication (GO:0006264)	2.77078154
70	double-strand break repair (GO:0006302)	2.75176909
71	C4-dicarboxylate transport (GO:0015740)	2.74341584
72	purine nucleobase biosynthetic process (GO:0009113)	2.73379022
73	epithelial cell differentiation involved in kidney development (GO:0035850)	2.73352900
74	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.73135064
75	tachykinin receptor signaling pathway (GO:0007217)	2.71456219
76	male meiosis (GO:0007140)	2.70793239
77	presynaptic membrane organization (GO:0097090)	2.69384032
78	DNA recombination (GO:0006310)	2.67630101
79	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.66536112
80	regulation of mitotic spindle checkpoint (GO:1903504)	2.66536112
81	quinone biosynthetic process (GO:1901663)	2.66323596
82	centriole assembly (GO:0098534)	2.65981016
83	microtubule organizing center organization (GO:0031023)	2.65936101
84	centrosome organization (GO:0051297)	2.62095107
85	ubiquinone biosynthetic process (GO:0006744)	2.61486648
86	microtubule anchoring (GO:0034453)	2.60999784
87	DNA ligation (GO:0006266)	2.60234208
88	spindle checkpoint (GO:0031577)	2.58232518
89	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.58199761
90	histone mRNA metabolic process (GO:0008334)	2.57747933
91	single strand break repair (GO:0000012)	2.55947660
92	ubiquinone metabolic process (GO:0006743)	2.55263266
93	cullin deneddylation (GO:0010388)	2.53617546
94	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.52517075
95	nonmotile primary cilium assembly (GO:0035058)	2.51298768
96	proteasome assembly (GO:0043248)	2.49278722
97	protein polyglutamylation (GO:0018095)	2.49252434
98	cilium organization (GO:0044782)	2.48965590
99	protein localization to kinetochore (GO:0034501)	2.48546348
100	cilium assembly (GO:0042384)	2.47939099

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.53236214
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.86582576
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.34072943
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.05082294
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98384569
6	FUS_26573619_Chip-Seq_HEK293_Human	2.66285228
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55419947
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.50807130
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.48297032
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.46180297
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41947060
12	VDR_22108803_ChIP-Seq_LS180_Human	2.25598393
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21246675
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.18470944
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.07705265
16	EWS_26573619_Chip-Seq_HEK293_Human	2.06029744
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03726689
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99887029
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.88304292
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.87244048
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.84244283
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.83942471
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79309431
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77260772
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74453070
26	P300_19829295_ChIP-Seq_ESCs_Human	1.73030483
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69521212
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.68004869
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.65603194
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62697316
31	GATA1_22025678_ChIP-Seq_K562_Human	1.62612652
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.61423632
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59857907
34	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.58566985
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56454970
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51095919
37	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.50317274
38	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.49402905
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.49222460
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47283977
41	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.43460510
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43384840
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.42002557
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37174760
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35666235
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34911407
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.33111893
48	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.31925675
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30758874
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.30758874
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30302109
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29771076
53	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.29300774
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29280886
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28493927
56	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26910981
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26498632
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26349950
59	STAT3_23295773_ChIP-Seq_U87_Human	1.26046139
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.25657036
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23477039
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20360648
63	AR_25329375_ChIP-Seq_VCAP_Human	1.20069591
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20020338
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19423675
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18550316
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17785640
68	TCF4_23295773_ChIP-Seq_U87_Human	1.17373213
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16885656
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15631170
71	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15551487
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12932830
73	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12924251
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11822250
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.11820035
76	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10572115
77	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.10425552
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07664806
79	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.07520522
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05063334
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03642303
82	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03205879
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01597819
84	JUN_21703547_ChIP-Seq_K562_Human	1.00569827
85	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00025345
86	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98385898
87	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.98308144
88	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98169033
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.95282558
90	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95131275
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94886307
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94886307
93	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94269406
94	P300_18555785_Chip-Seq_ESCs_Mouse	0.94134946
95	RXR_22108803_ChIP-Seq_LS180_Human	0.93888392
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92576014
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91567642
98	TP53_16413492_ChIP-PET_HCT116_Human	0.91052301
99	FOXP3_21729870_ChIP-Seq_TREG_Human	0.90964622
100	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.90758112

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.82774184
2	MP0010094_abnormal_chromosome_stability	3.54721354
3	MP0003880_abnormal_central_pattern	3.43181916
4	MP0008058_abnormal_DNA_repair	3.31323143
5	MP0008877_abnormal_DNA_methylation	3.17598233
6	MP0009697_abnormal_copulation	2.91728662
7	MP0000372_irregular_coat_pigmentation	2.89589052
8	MP0003136_yellow_coat_color	2.78783296
9	MP0002736_abnormal_nociception_after	2.57527925
10	MP0002938_white_spotting	2.51823395
11	MP0000569_abnormal_digit_pigmentation	2.28856078
12	MP0006276_abnormal_autonomic_nervous	2.21571463
13	MP0004147_increased_porphyrin_level	2.06729482
14	MP0006292_abnormal_olfactory_placode	2.03304392
15	MP0001346_abnormal_lacrimal_gland	1.98655358
16	MP0005645_abnormal_hypothalamus_physiol	1.92735573
17	MP0003111_abnormal_nucleus_morphology	1.92609658
18	MP0003718_maternal_effect	1.91114430
19	MP0001968_abnormal_touch/_nociception	1.81273328
20	MP0002102_abnormal_ear_morphology	1.70428712
21	MP0002163_abnormal_gland_morphology	1.68484752
22	MP0001764_abnormal_homeostasis	1.66320690
23	MP0002735_abnormal_chemical_nociception	1.63848296
24	MP0005551_abnormal_eye_electrophysiolog	1.63714282
25	MP0002282_abnormal_trachea_morphology	1.53363437
26	MP0003786_premature_aging	1.52755728
27	MP0003890_abnormal_embryonic-extraembry	1.52382883
28	MP0002822_catalepsy	1.43022058
29	MP0000427_abnormal_hair_cycle	1.37011676
30	MP0002638_abnormal_pupillary_reflex	1.31224912
31	MP0006072_abnormal_retinal_apoptosis	1.31050238
32	MP0001293_anophthalmia	1.29933043
33	MP0005379_endocrine/exocrine_gland_phen	1.29555674
34	MP0009745_abnormal_behavioral_response	1.29035124
35	MP0008995_early_reproductive_senescence	1.27602194
36	MP0002697_abnormal_eye_size	1.27213669
37	MP0003077_abnormal_cell_cycle	1.27065716
38	MP0008932_abnormal_embryonic_tissue	1.26188162
39	MP0002751_abnormal_autonomic_nervous	1.23422375
40	MP0000631_abnormal_neuroendocrine_gland	1.21826112
41	MP0002160_abnormal_reproductive_system	1.21459858
42	MP0000647_abnormal_sebaceous_gland	1.20639504
43	MP0002234_abnormal_pharynx_morphology	1.17716578
44	MP0003693_abnormal_embryo_hatching	1.17632837
45	MP0001486_abnormal_startle_reflex	1.16098155
46	MP0001929_abnormal_gametogenesis	1.14816997
47	MP0004043_abnormal_pH_regulation	1.14141289
48	MP0005253_abnormal_eye_physiology	1.10461850
49	MP0001348_abnormal_lacrimal_gland	1.10425635
50	MP0006035_abnormal_mitochondrial_morpho	1.09977631
51	MP0003937_abnormal_limbs/digits/tail_de	1.09281826
52	MP0001529_abnormal_vocalization	1.09254833
53	MP0000383_abnormal_hair_follicle	1.08098792
54	MP0003943_abnormal_hepatobiliary_system	1.07744945
55	MP0008775_abnormal_heart_ventricle	1.06530500
56	MP0000358_abnormal_cell_content/	1.06080285
57	MP0004215_abnormal_myocardial_fiber	1.04879194
58	MP0003698_abnormal_male_reproductive	0.99787500
59	MP0003878_abnormal_ear_physiology	0.99734660
60	MP0005377_hearing/vestibular/ear_phenot	0.99734660
61	MP0006054_spinal_hemorrhage	0.99613235
62	MP0004859_abnormal_synaptic_plasticity	0.98936136
63	MP0000778_abnormal_nervous_system	0.97721327
64	MP0004957_abnormal_blastocyst_morpholog	0.97615053
65	MP0004133_heterotaxia	0.96334107
66	MP0005195_abnormal_posterior_eye	0.95924899
67	MP0005367_renal/urinary_system_phenotyp	0.95534674
68	MP0000516_abnormal_urinary_system	0.95534674
69	MP0000653_abnormal_sex_gland	0.95102979
70	MP0002210_abnormal_sex_determination	0.94099792
71	MP0010307_abnormal_tumor_latency	0.93293874
72	MP0002876_abnormal_thyroid_physiology	0.92788408
73	MP0003950_abnormal_plasma_membrane	0.91022764
74	MP0009046_muscle_twitch	0.88973969
75	MP0000049_abnormal_middle_ear	0.87399001
76	MP0001119_abnormal_female_reproductive	0.86885362
77	MP0005395_other_phenotype	0.85195280
78	MP0003252_abnormal_bile_duct	0.85102209
79	MP0001145_abnormal_male_reproductive	0.84551123
80	MP0002090_abnormal_vision	0.83668432
81	MP0005391_vision/eye_phenotype	0.83473035
82	MP0003861_abnormal_nervous_system	0.82135856
83	MP0001324_abnormal_eye_pigmentation	0.79764584
84	MP0008872_abnormal_physiological_respon	0.79355522
85	MP0002127_abnormal_cardiovascular_syste	0.76987354
86	MP0003635_abnormal_synaptic_transmissio	0.76794286
87	MP0002063_abnormal_learning/memory/cond	0.76299844
88	MP0001697_abnormal_embryo_size	0.73908675
89	MP0002752_abnormal_somatic_nervous	0.73696783
90	MP0005187_abnormal_penis_morphology	0.73613217
91	MP0010030_abnormal_orbit_morphology	0.73079214
92	MP0001177_atelectasis	0.72158685
93	MP0005174_abnormal_tail_pigmentation	0.72128821
94	MP0006036_abnormal_mitochondrial_physio	0.71885803
95	MP0001984_abnormal_olfaction	0.71519879
96	MP0001286_abnormal_eye_development	0.71115519
97	MP0003755_abnormal_palate_morphology	0.70316168
98	MP0003567_abnormal_fetal_cardiomyocyte	0.70155070
99	MP0008007_abnormal_cellular_replicative	0.68648823
100	MP0005646_abnormal_pituitary_gland	0.67659732

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.56275367
2	True hermaphroditism (HP:0010459)	3.97350293
3	Pancreatic cysts (HP:0001737)	3.90109079
4	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.89879087
5	Ependymoma (HP:0002888)	3.75225724
6	Hypoplastic pelvis (HP:0008839)	3.57406397
7	Abnormality of the astrocytes (HP:0100707)	3.54024117
8	Astrocytoma (HP:0009592)	3.54024117
9	Chromsome breakage (HP:0040012)	3.41322344
10	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.36598044
11	Abnormality of chromosome stability (HP:0003220)	3.33307878
12	Abnormality of the ileum (HP:0001549)	3.28101539
13	Pendular nystagmus (HP:0012043)	3.25719040
14	Meckel diverticulum (HP:0002245)	3.22602579
15	Stenosis of the external auditory canal (HP:0000402)	3.15504487
16	Abnormality of the labia minora (HP:0012880)	3.13629382
17	Abnormality of the preputium (HP:0100587)	3.07352754
18	Colon cancer (HP:0003003)	3.06630669
19	Cystic liver disease (HP:0006706)	3.02949201
20	Sloping forehead (HP:0000340)	2.99349580
21	Glioma (HP:0009733)	2.91816493
22	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.81772230
23	Birth length less than 3rd percentile (HP:0003561)	2.77608938
24	Rhabdomyosarcoma (HP:0002859)	2.77337902
25	Agnosia (HP:0010524)	2.61463436
26	Tubulointerstitial abnormality (HP:0001969)	2.58660658
27	Abnormality of DNA repair (HP:0003254)	2.52052994
28	Sclerocornea (HP:0000647)	2.49329617
29	Cholecystitis (HP:0001082)	2.47762391
30	Abnormal gallbladder physiology (HP:0012438)	2.47762391
31	Absent speech (HP:0001344)	2.47020953
32	Postaxial foot polydactyly (HP:0001830)	2.46210343
33	Tubulointerstitial nephritis (HP:0001970)	2.42568774
34	Broad-based gait (HP:0002136)	2.41046858
35	Nephronophthisis (HP:0000090)	2.40847739
36	Tubulointerstitial fibrosis (HP:0005576)	2.39651929
37	Genital tract atresia (HP:0001827)	2.38019243
38	Optic nerve hypoplasia (HP:0000609)	2.36431174
39	Medulloblastoma (HP:0002885)	2.31184707
40	Nephrogenic diabetes insipidus (HP:0009806)	2.25908168
41	Volvulus (HP:0002580)	2.24547529
42	Abnormality of the renal medulla (HP:0100957)	2.23647503
43	Congenital hepatic fibrosis (HP:0002612)	2.21370054
44	Abnormality of the carotid arteries (HP:0005344)	2.19840569
45	Abnormality of macular pigmentation (HP:0008002)	2.16321342
46	Vaginal atresia (HP:0000148)	2.15918443
47	Proximal tubulopathy (HP:0000114)	2.14745576
48	Methylmalonic acidemia (HP:0002912)	2.12766534
49	Hyperventilation (HP:0002883)	2.12255727
50	Preaxial hand polydactyly (HP:0001177)	2.12076348
51	Gait imbalance (HP:0002141)	2.12052682
52	Small hand (HP:0200055)	2.11787699
53	Congenital primary aphakia (HP:0007707)	2.11714308
54	Small intestinal stenosis (HP:0012848)	2.10577337
55	Duodenal stenosis (HP:0100867)	2.10577337
56	Oligodactyly (hands) (HP:0001180)	2.10433224
57	Medial flaring of the eyebrow (HP:0010747)	2.08807795
58	Decreased central vision (HP:0007663)	2.05995871
59	Abnormality of the labia majora (HP:0012881)	2.05340084
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04624709
61	Anencephaly (HP:0002323)	2.03972101
62	Absent radius (HP:0003974)	2.03856898
63	Genetic anticipation (HP:0003743)	2.02578269
64	Neoplasm of striated muscle (HP:0009728)	2.02501588
65	Posterior subcapsular cataract (HP:0007787)	2.01904536
66	Aplasia involving forearm bones (HP:0009822)	2.01740043
67	Absent forearm bone (HP:0003953)	2.01740043
68	Severe visual impairment (HP:0001141)	2.00623646
69	Gaze-evoked nystagmus (HP:0000640)	2.00001932
70	Attenuation of retinal blood vessels (HP:0007843)	1.99655616
71	Aqueductal stenosis (HP:0002410)	1.95172947
72	Congenital stationary night blindness (HP:0007642)	1.92952515
73	Astigmatism (HP:0000483)	1.92552859
74	Clubbing of toes (HP:0100760)	1.92024721
75	Neoplasm of the oral cavity (HP:0100649)	1.89620614
76	Molar tooth sign on MRI (HP:0002419)	1.89000989
77	Abnormality of midbrain morphology (HP:0002418)	1.89000989
78	Abnormality of the duodenum (HP:0002246)	1.86979748
79	Carpal bone hypoplasia (HP:0001498)	1.86742665
80	Postaxial hand polydactyly (HP:0001162)	1.86415417
81	Hypoplastic labia majora (HP:0000059)	1.85938470
82	Oligohydramnios (HP:0001562)	1.85507301
83	Supernumerary spleens (HP:0009799)	1.85221573
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.84500459
85	Absent/shortened dynein arms (HP:0200106)	1.84500459
86	Furrowed tongue (HP:0000221)	1.81097307
87	Anophthalmia (HP:0000528)	1.80888924
88	Hypoplastic female external genitalia (HP:0012815)	1.80078929
89	Patellar aplasia (HP:0006443)	1.78214977
90	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.76380227
91	Cupped ear (HP:0000378)	1.76020191
92	Ectopic kidney (HP:0000086)	1.75723964
93	Multicystic kidney dysplasia (HP:0000003)	1.72886418
94	Methylmalonic aciduria (HP:0012120)	1.71351724
95	Intestinal atresia (HP:0011100)	1.71259785
96	Hypoplastic nipples (HP:0002557)	1.70332759
97	Male pseudohermaphroditism (HP:0000037)	1.68774755
98	Dandy-Walker malformation (HP:0001305)	1.67749670
99	Hyperglycinemia (HP:0002154)	1.67617689
100	Dysdiadochokinesis (HP:0002075)	1.67053459

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	5.55468427
2	BCR	4.24280087
3	CASK	3.84615412
4	MAP3K4	2.71782365
5	PLK4	2.59446121
6	BRSK2	2.57274464
7	FRK	2.50926940
8	MKNK2	2.40628584
9	TNIK	2.32001322
10	PNCK	2.20178021
11	BMPR1B	2.14122853
12	ACVR1B	1.99200225
13	MAP2K7	1.97535254
14	MARK1	1.87240992
15	WNK3	1.77202343
16	CDC7	1.72769574
17	WEE1	1.66840277
18	MKNK1	1.61889956
19	PLK2	1.60328310
20	PIK3CG	1.60304650
21	BUB1	1.48328381
22	BRD4	1.43826773
23	NEK1	1.43428067
24	NUAK1	1.35468647
25	SIK3	1.35350857
26	TAF1	1.31993654
27	TTK	1.31020813
28	SRPK1	1.30056255
29	ERBB3	1.27592571
30	PLK1	1.27162615
31	DYRK3	1.26101229
32	OXSR1	1.25226800
33	PLK3	1.16483183
34	INSRR	1.12747404
35	BRSK1	1.12583201
36	STK3	1.11982109
37	MINK1	1.10876708
38	NTRK3	1.09057320
39	DYRK2	1.04560245
40	STK39	1.03700533
41	EPHA4	1.00360310
42	CDK19	0.99888079
43	DYRK1A	0.94446312
44	FER	0.92047122
45	MAPK13	0.91952400
46	EPHA3	0.89977356
47	FGFR2	0.85274575
48	FGFR1	0.83877733
49	PINK1	0.82802888
50	TGFBR1	0.80059901
51	EIF2AK3	0.78700540
52	ZAK	0.77587649
53	AURKB	0.75674016
54	MAP3K3	0.74977512
55	CCNB1	0.74318499
56	NTRK2	0.73499807
57	CHEK2	0.72897245
58	MAP2K4	0.71469574
59	ATR	0.69870103
60	VRK2	0.69610465
61	PRKCG	0.68719992
62	ATM	0.68279774
63	CSNK1G1	0.64031967
64	CHEK1	0.60172591
65	NEK2	0.58975004
66	ADRBK2	0.56764592
67	CDK3	0.56458029
68	GRK1	0.56199992
69	DYRK1B	0.56057157
70	YES1	0.53599225
71	VRK1	0.53572006
72	STK38L	0.50620464
73	MET	0.49664068
74	MST4	0.49133588
75	WNK4	0.46985169
76	CSNK1G3	0.46928279
77	CSNK1G2	0.43761526
78	TSSK6	0.43274683
79	LATS1	0.43245664
80	PAK3	0.43089497
81	AURKA	0.41076014
82	GRK5	0.40796575
83	RPS6KA4	0.40669649
84	PRKCE	0.38125955
85	DAPK2	0.35690116
86	CDK18	0.35275915
87	CDK1	0.34414041
88	CAMK1G	0.34060627
89	PKN1	0.33509338
90	CSNK1A1L	0.33267059
91	PRKDC	0.32845957
92	MAP4K2	0.32394700
93	MATK	0.31512793
94	PRKACB	0.27317372
95	CDK2	0.25990351
96	GSK3A	0.24675329
97	CAMK2A	0.24562004
98	EGFR	0.23485001
99	ERBB4	0.23033885
100	PBK	0.22915416

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	4.11654510
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.88068496
3	Mismatch repair_Homo sapiens_hsa03430	3.82444123
4	Homologous recombination_Homo sapiens_hsa03440	3.41602397
5	DNA replication_Homo sapiens_hsa03030	3.05666390
6	Nicotine addiction_Homo sapiens_hsa05033	2.50983095
7	Basal transcription factors_Homo sapiens_hsa03022	2.29565133
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.09336527
9	Phototransduction_Homo sapiens_hsa04744	2.08390896
10	Protein export_Homo sapiens_hsa03060	1.98972785
11	Nucleotide excision repair_Homo sapiens_hsa03420	1.94431896
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.93720136
13	Base excision repair_Homo sapiens_hsa03410	1.90179026
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.86101428
15	RNA polymerase_Homo sapiens_hsa03020	1.83681720
16	Propanoate metabolism_Homo sapiens_hsa00640	1.80492881
17	Pyrimidine metabolism_Homo sapiens_hsa00240	1.65685210
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.58553955
19	Cell cycle_Homo sapiens_hsa04110	1.50280344
20	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.42704428
21	Spliceosome_Homo sapiens_hsa03040	1.38587634
22	RNA transport_Homo sapiens_hsa03013	1.35289602
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.32245863
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31652773
25	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.30981378
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.29590439
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29439948
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.29309998
29	Butanoate metabolism_Homo sapiens_hsa00650	1.27006651
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.26045628
31	Proteasome_Homo sapiens_hsa03050	1.26026641
32	Taste transduction_Homo sapiens_hsa04742	1.18084682
33	Purine metabolism_Homo sapiens_hsa00230	1.16717919
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12982725
35	p53 signaling pathway_Homo sapiens_hsa04115	1.09072878
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07385872
37	Oocyte meiosis_Homo sapiens_hsa04114	1.07232245
38	Glutathione metabolism_Homo sapiens_hsa00480	1.06869508
39	RNA degradation_Homo sapiens_hsa03018	1.06503947
40	Circadian rhythm_Homo sapiens_hsa04710	1.04859965
41	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.04459286
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.95292787
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94475990
44	Olfactory transduction_Homo sapiens_hsa04740	0.92209102
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92116373
46	Circadian entrainment_Homo sapiens_hsa04713	0.91962066
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91814140
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89801111
49	One carbon pool by folate_Homo sapiens_hsa00670	0.88801781
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88800614
51	Renin-angiotensin system_Homo sapiens_hsa04614	0.86815040
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.85875557
53	GABAergic synapse_Homo sapiens_hsa04727	0.85240347
54	Basal cell carcinoma_Homo sapiens_hsa05217	0.82374328
55	Caffeine metabolism_Homo sapiens_hsa00232	0.78851589
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75004709
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.74570180
58	Regulation of autophagy_Homo sapiens_hsa04140	0.73435449
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.66938519
60	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.65114326
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.65079228
62	Peroxisome_Homo sapiens_hsa04146	0.63314480
63	Amphetamine addiction_Homo sapiens_hsa05031	0.62644674
64	Morphine addiction_Homo sapiens_hsa05032	0.62349582
65	Huntingtons disease_Homo sapiens_hsa05016	0.60623523
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.60610427
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60557031
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60266053
69	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59767195
70	Lysine degradation_Homo sapiens_hsa00310	0.59125609
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56147706
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.55101727
73	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.54156037
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53340671
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.50369894
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49874609
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48759721
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48681489
79	Wnt signaling pathway_Homo sapiens_hsa04310	0.48408626
80	African trypanosomiasis_Homo sapiens_hsa05143	0.46248196
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45196933
82	Cocaine addiction_Homo sapiens_hsa05030	0.43196359
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.42812220
84	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42047387
85	Metabolic pathways_Homo sapiens_hsa01100	0.41922549
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41721301
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39981468
88	Salivary secretion_Homo sapiens_hsa04970	0.39637374
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38469533
90	Long-term depression_Homo sapiens_hsa04730	0.37517697
91	Serotonergic synapse_Homo sapiens_hsa04726	0.37275231
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.36932461
93	Retinol metabolism_Homo sapiens_hsa00830	0.36293913
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36226956
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.35136871
96	Parkinsons disease_Homo sapiens_hsa05012	0.35030621
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34887773
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.32535597
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.31032432
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.30794874

SETP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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