SETP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to histamine (GO:0034776)6.36479859
2protein polyglutamylation (GO:0018095)5.87567243
3regulation of cilium movement (GO:0003352)5.71060182
4positive regulation of mitochondrial fission (GO:0090141)5.26118836
5tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.17867093
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.17867093
7DNA double-strand break processing (GO:0000729)4.67846714
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.47313423
9vocalization behavior (GO:0071625)4.25631495
10cellular response to leptin stimulus (GO:0044320)4.22354864
11sequestering of actin monomers (GO:0042989)4.20734591
12negative regulation of appetite (GO:0032099)4.15070032
13negative regulation of response to food (GO:0032096)4.15070032
14nonmotile primary cilium assembly (GO:0035058)4.12768257
15histone H2A acetylation (GO:0043968)4.03021660
16regulation of glycogen (starch) synthase activity (GO:2000465)3.99282771
17resolution of meiotic recombination intermediates (GO:0000712)3.99199380
18proteasome assembly (GO:0043248)3.97781928
19water-soluble vitamin biosynthetic process (GO:0042364)3.94573331
20replication fork processing (GO:0031297)3.85383080
21DNA strand renaturation (GO:0000733)3.83489591
22long-chain fatty acid biosynthetic process (GO:0042759)3.77119925
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.76146936
24blood coagulation, intrinsic pathway (GO:0007597)3.62961810
25CENP-A containing nucleosome assembly (GO:0034080)3.62370065
26protein neddylation (GO:0045116)3.60947812
27protein K11-linked deubiquitination (GO:0035871)3.60938481
28regulation of mitochondrial fission (GO:0090140)3.60892731
29chromatin remodeling at centromere (GO:0031055)3.57539416
30striatum development (GO:0021756)3.56267599
31axoneme assembly (GO:0035082)3.54686532
32epithelial cilium movement (GO:0003351)3.50939119
33alkaloid metabolic process (GO:0009820)3.41480000
34retinal rod cell development (GO:0046548)3.38239862
35response to leptin (GO:0044321)3.35710466
36protein deneddylation (GO:0000338)3.33090551
37histone exchange (GO:0043486)3.28306220
38brain morphogenesis (GO:0048854)3.28055333
39negative regulation of DNA recombination (GO:0045910)3.27850065
40cellular response to ammonium ion (GO:0071242)3.16922103
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15821672
42ovulation cycle (GO:0042698)3.14968305
43regulation of translation, ncRNA-mediated (GO:0045974)3.14555910
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.14555910
45negative regulation of translation, ncRNA-mediated (GO:0040033)3.14555910
46thrombin receptor signaling pathway (GO:0070493)3.10364915
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09367394
48gamma-aminobutyric acid transport (GO:0015812)3.07251625
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07167121
50response to gravity (GO:0009629)3.05524024
51DNA replication-dependent nucleosome organization (GO:0034723)3.04863377
52DNA replication-dependent nucleosome assembly (GO:0006335)3.04863377
53carnitine metabolic process (GO:0009437)3.03909263
54synapsis (GO:0007129)2.99406186
55cullin deneddylation (GO:0010388)2.96709842
56regulation of response to food (GO:0032095)2.96188376
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96169891
58DNA replication checkpoint (GO:0000076)2.96026450
59DNA catabolic process, exonucleolytic (GO:0000738)2.96000904
60response to pheromone (GO:0019236)2.95372320
61detection of light stimulus involved in sensory perception (GO:0050962)2.92512609
62detection of light stimulus involved in visual perception (GO:0050908)2.92512609
63regulation of microtubule-based movement (GO:0060632)2.91307223
64DNA replication-independent nucleosome assembly (GO:0006336)2.89185844
65DNA replication-independent nucleosome organization (GO:0034724)2.89185844
66negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.88514386
67microtubule depolymerization (GO:0007019)2.87687337
68telomere maintenance via recombination (GO:0000722)2.85642654
69cellular response to interferon-beta (GO:0035458)2.83508798
70double-strand break repair via homologous recombination (GO:0000724)2.83484922
71linoleic acid metabolic process (GO:0043651)2.83348084
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82532303
73behavioral response to nicotine (GO:0035095)2.81538614
74regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.78990144
75regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.78990144
76cellular hyperosmotic response (GO:0071474)2.78208652
77recombinational repair (GO:0000725)2.78199621
78neuron cell-cell adhesion (GO:0007158)2.78050663
79DNA damage response, detection of DNA damage (GO:0042769)2.73937745
80lipoxygenase pathway (GO:0019372)2.73260914
81neural tube formation (GO:0001841)2.72084372
82photoreceptor cell maintenance (GO:0045494)2.69985732
83mitotic recombination (GO:0006312)2.69583330
84regulation of appetite (GO:0032098)2.69540798
85regulation of inositol phosphate biosynthetic process (GO:0010919)2.67682930
86platelet aggregation (GO:0070527)2.67362871
87regulation of helicase activity (GO:0051095)2.67262014
88positive regulation of protein depolymerization (GO:1901881)2.65354883
89intraciliary transport (GO:0042073)2.62575568
90regulation of neurotransmitter uptake (GO:0051580)2.62395605
91protein K63-linked deubiquitination (GO:0070536)2.60572628
92single strand break repair (GO:0000012)2.59804634
93cilium morphogenesis (GO:0060271)2.59765189
94positive regulation of megakaryocyte differentiation (GO:0045654)2.59470740
95lactate metabolic process (GO:0006089)2.59340715
96lysine catabolic process (GO:0006554)2.59133448
97lysine metabolic process (GO:0006553)2.59133448
98regulation of histone H3-K9 methylation (GO:0051570)2.56728995
99cilium movement (GO:0003341)2.56359966
100basic amino acid transport (GO:0015802)10.1522164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.77642062
2E2F7_22180533_ChIP-Seq_HELA_Human4.05715353
3EZH2_22144423_ChIP-Seq_EOC_Human3.85332221
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.51891092
5VDR_22108803_ChIP-Seq_LS180_Human3.19914941
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94764578
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66337684
8TAF15_26573619_Chip-Seq_HEK293_Human2.59817004
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.56430867
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50054893
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49056671
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45293584
13ZNF274_21170338_ChIP-Seq_K562_Hela2.39458596
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.34422202
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28213377
16FUS_26573619_Chip-Seq_HEK293_Human2.24170779
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23941204
18IGF1R_20145208_ChIP-Seq_DFB_Human2.23103303
19EWS_26573619_Chip-Seq_HEK293_Human2.22954294
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22496450
21P300_19829295_ChIP-Seq_ESCs_Human2.13442868
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.13017889
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.77524964
24CBP_20019798_ChIP-Seq_JUKART_Human1.77524964
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.75779484
26BCAT_22108803_ChIP-Seq_LS180_Human1.73530918
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70069144
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69400981
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68886211
30HTT_18923047_ChIP-ChIP_STHdh_Human1.67755190
31ELK1_19687146_ChIP-ChIP_HELA_Human1.67612885
32GBX2_23144817_ChIP-Seq_PC3_Human1.62955798
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61140290
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56860803
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52663814
36SMAD4_21799915_ChIP-Seq_A2780_Human1.51794722
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47973744
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44743141
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43802152
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41722531
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41536171
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41048254
43VDR_23849224_ChIP-Seq_CD4+_Human1.39300873
44ER_23166858_ChIP-Seq_MCF-7_Human1.35455674
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32389664
46IRF1_19129219_ChIP-ChIP_H3396_Human1.29481321
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.28947423
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.28064089
49PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27666820
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27490376
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26481228
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25122586
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23260632
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.21404467
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21240164
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20252840
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20252840
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18200141
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17685392
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17332624
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15639437
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14774979
63TCF4_22108803_ChIP-Seq_LS180_Human1.14644984
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13527092
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12924260
66MYC_18940864_ChIP-ChIP_HL60_Human1.12592101
67NANOG_19829295_ChIP-Seq_ESCs_Human1.12418153
68SOX2_19829295_ChIP-Seq_ESCs_Human1.12418153
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11982875
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10956608
71DCP1A_22483619_ChIP-Seq_HELA_Human1.07643434
72STAT3_23295773_ChIP-Seq_U87_Human1.06808556
73SCL_19346495_ChIP-Seq_HPC-7_Human1.06517497
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.06079771
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05635279
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05594329
77RNF2_27304074_Chip-Seq_NSC_Mouse1.04896710
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.03461762
79TP53_22573176_ChIP-Seq_HFKS_Human1.02178742
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00493118
81NANOG_16153702_ChIP-ChIP_HESCs_Human0.98219851
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97981856
83FOXP3_21729870_ChIP-Seq_TREG_Human0.97961518
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97569000
85AR_25329375_ChIP-Seq_VCAP_Human0.96580145
86TCF4_23295773_ChIP-Seq_U87_Human0.95763257
87E2F1_18555785_Chip-Seq_ESCs_Mouse0.95228527
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94782953
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.94312460
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93975982
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93871568
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93535576
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.93499289
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92376844
95RUNX2_22187159_ChIP-Seq_PCA_Human0.91227981
96MYC_18555785_ChIP-Seq_MESCs_Mouse0.90819672
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90327384
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.90327384
99P300_18555785_Chip-Seq_ESCs_Mouse0.89517247
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89213016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000465_gastrointestinal_hemorrhage4.05182129
2MP0008877_abnormal_DNA_methylation4.03025803
3MP0006054_spinal_hemorrhage3.70936640
4MP0002736_abnormal_nociception_after3.46924767
5MP0001984_abnormal_olfaction3.03208991
6MP0001968_abnormal_touch/_nociception2.97062826
7MP0003122_maternal_imprinting2.70638256
8MP0004885_abnormal_endolymph2.56210115
9MP0003787_abnormal_imprinting2.48442880
10MP0003693_abnormal_embryo_hatching2.47158547
11MP0004215_abnormal_myocardial_fiber2.46640297
12MP0003121_genomic_imprinting2.19924651
13MP0003880_abnormal_central_pattern2.15925008
14MP0003890_abnormal_embryonic-extraembry2.11274135
15MP0003183_abnormal_peptide_metabolism2.04382226
16MP0008058_abnormal_DNA_repair2.02833781
17MP0008004_abnormal_stomach_pH2.01662901
18MP0002734_abnormal_mechanical_nocicepti1.99063882
19MP0005670_abnormal_white_adipose1.97493485
20MP0001486_abnormal_startle_reflex1.96170417
21MP0006292_abnormal_olfactory_placode1.94487646
22MP0004133_heterotaxia1.93180167
23MP0010094_abnormal_chromosome_stability1.90593471
24MP0008872_abnormal_physiological_respon1.83092904
25MP0002837_dystrophic_cardiac_calcinosis1.81066478
26MP0002733_abnormal_thermal_nociception1.79133105
27MP0005464_abnormal_platelet_physiology1.74947985
28MP0003011_delayed_dark_adaptation1.73764188
29MP0008789_abnormal_olfactory_epithelium1.67687218
30MP0001970_abnormal_pain_threshold1.63587778
31MP0009745_abnormal_behavioral_response1.58045904
32MP0000569_abnormal_digit_pigmentation1.46415026
33MP0004185_abnormal_adipocyte_glucose1.44181541
34MP0005551_abnormal_eye_electrophysiolog1.44151394
35MP0004957_abnormal_blastocyst_morpholog1.41947974
36MP0006072_abnormal_retinal_apoptosis1.36996142
37MP0006035_abnormal_mitochondrial_morpho1.33242909
38MP0000778_abnormal_nervous_system1.30844046
39MP0001727_abnormal_embryo_implantation1.30152487
40MP0005253_abnormal_eye_physiology1.29815527
41MP0003186_abnormal_redox_activity1.29493331
42MP0008932_abnormal_embryonic_tissue1.26999970
43MP0003718_maternal_effect1.21796031
44MP0005394_taste/olfaction_phenotype1.21564261
45MP0005499_abnormal_olfactory_system1.21564261
46MP0001440_abnormal_grooming_behavior1.20350770
47MP0003635_abnormal_synaptic_transmissio1.18588920
48MP0005423_abnormal_somatic_nervous1.15469122
49MP0005646_abnormal_pituitary_gland1.14725235
50MP0002572_abnormal_emotion/affect_behav1.14135408
51MP0002638_abnormal_pupillary_reflex1.13229234
52MP0002735_abnormal_chemical_nociception1.13114485
53MP0003943_abnormal_hepatobiliary_system1.09640385
54MP0000566_synostosis1.07839920
55MP0002063_abnormal_learning/memory/cond1.06756882
56MP0002272_abnormal_nervous_system1.06644621
57MP0001929_abnormal_gametogenesis1.02160428
58MP0001485_abnormal_pinna_reflex1.00620077
59MP0002064_seizures0.98428968
60MP0001529_abnormal_vocalization0.95467803
61MP0005075_abnormal_melanosome_morpholog0.95280907
62MP0008007_abnormal_cellular_replicative0.93718773
63MP0003633_abnormal_nervous_system0.93066082
64MP0002067_abnormal_sensory_capabilities0.92813616
65MP0006276_abnormal_autonomic_nervous0.91173652
66MP0002210_abnormal_sex_determination0.89986349
67MP0001905_abnormal_dopamine_level0.87078058
68MP0005367_renal/urinary_system_phenotyp0.86877075
69MP0000516_abnormal_urinary_system0.86877075
70MP0001963_abnormal_hearing_physiology0.86277840
71MP0000653_abnormal_sex_gland0.86200643
72MP0002751_abnormal_autonomic_nervous0.84152170
73MP0001145_abnormal_male_reproductive0.81630679
74MP0008057_abnormal_DNA_replication0.77896303
75MP0002909_abnormal_adrenal_gland0.76816527
76MP0003077_abnormal_cell_cycle0.75405216
77MP0008875_abnormal_xenobiotic_pharmacok0.75204585
78MP0005666_abnormal_adipose_tissue0.74924761
79MP0002938_white_spotting0.74783479
80MP0003111_abnormal_nucleus_morphology0.73366441
81MP0001188_hyperpigmentation0.73157321
82MP0009703_decreased_birth_body0.73086422
83MP0003221_abnormal_cardiomyocyte_apopto0.71872409
84MP0003698_abnormal_male_reproductive0.71103636
85MP0001851_eye_inflammation0.70801438
86MP0002069_abnormal_eating/drinking_beha0.70712113
87MP0003938_abnormal_ear_development0.69821864
88MP0000358_abnormal_cell_content/0.69321469
89MP0000383_abnormal_hair_follicle0.68724439
90MP0005266_abnormal_metabolism0.68121664
91MP0003137_abnormal_impulse_conducting0.66569478
92MP0003567_abnormal_fetal_cardiomyocyte0.66000314
93MP0004130_abnormal_muscle_cell0.65956026
94MP0003786_premature_aging0.65306695
95MP0009046_muscle_twitch0.61667376
96MP0008873_increased_physiological_sensi0.61241191
97MP0001697_abnormal_embryo_size0.60578097
98MP0001119_abnormal_female_reproductive0.59715160
99MP0006036_abnormal_mitochondrial_physio0.59604587
100MP0010770_preweaning_lethality0.59460179

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)6.21680721
2Petechiae (HP:0000967)5.83390959
3Abnormal platelet volume (HP:0011876)5.69104655
4Prolonged bleeding time (HP:0003010)5.51509411
5Menorrhagia (HP:0000132)4.77458447
6Purpura (HP:0000979)4.31237411
7Hyperthyroidism (HP:0000836)3.79075919
8Hyperglycinemia (HP:0002154)3.61914986
9Chromsome breakage (HP:0040012)3.27107859
10Methylmalonic acidemia (HP:0002912)3.24159213
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23917880
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.15872110
13Absent/shortened dynein arms (HP:0200106)3.15872110
14Agnosia (HP:0010524)3.10138031
15Volvulus (HP:0002580)3.08560086
16Nephrogenic diabetes insipidus (HP:0009806)2.93212731
17Limb dystonia (HP:0002451)2.85377206
18Epistaxis (HP:0000421)2.79996539
19Abnormal respiratory motile cilium morphology (HP:0005938)2.70485537
20Abnormal respiratory epithelium morphology (HP:0012253)2.70485537
21Congenital primary aphakia (HP:0007707)2.70457667
22Amyotrophic lateral sclerosis (HP:0007354)2.68435235
23Gingival bleeding (HP:0000225)2.66299739
24Gait imbalance (HP:0002141)2.63712118
25Aplasia cutis congenita (HP:0001057)2.57125708
26Pancreatic fibrosis (HP:0100732)2.56446302
27Hypothermia (HP:0002045)2.55889365
28Impaired platelet aggregation (HP:0003540)2.53102304
29Abnormal platelet function (HP:0011869)2.53102304
30Aplastic anemia (HP:0001915)2.52143838
31True hermaphroditism (HP:0010459)2.51713302
32Medial flaring of the eyebrow (HP:0010747)2.51009968
33Progressive macrocephaly (HP:0004481)2.50865738
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.47496376
35Abnormality of the tricuspid valve (HP:0001702)2.46058664
36Abnormality of the ileum (HP:0001549)2.42140846
37Abnormality of the labia minora (HP:0012880)2.40274238
38Central scotoma (HP:0000603)2.38073067
39Acute necrotizing encephalopathy (HP:0006965)2.36060072
40Abnormal biliary tract physiology (HP:0012439)2.35512258
41Bile duct proliferation (HP:0001408)2.35512258
42Methylmalonic aciduria (HP:0012120)2.35328531
43Acute encephalopathy (HP:0006846)2.33336330
44Facial diplegia (HP:0001349)2.30625099
45Abnormality of serine family amino acid metabolism (HP:0010894)2.30132529
46Abnormality of glycine metabolism (HP:0010895)2.30132529
47Pancreatic cysts (HP:0001737)2.30017141
48Abnormality of chromosome stability (HP:0003220)2.29951811
49Colon cancer (HP:0003003)2.26636926
50Abnormal ciliary motility (HP:0012262)2.21925320
51Genital tract atresia (HP:0001827)2.21777088
52Chronic bronchitis (HP:0004469)2.18948254
53Abnormality of the preputium (HP:0100587)2.18852056
54Abnormality of serum amino acid levels (HP:0003112)2.18776425
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.13577044
56Increased CSF lactate (HP:0002490)2.11568339
57Stomach cancer (HP:0012126)2.07411466
58Vaginal atresia (HP:0000148)2.06505581
59Aplasia/Hypoplasia of the earlobes (HP:0009906)2.05797008
60Meckel diverticulum (HP:0002245)2.04837133
61Optic disc pallor (HP:0000543)2.04660632
62Mitochondrial inheritance (HP:0001427)2.00259190
63Myelodysplasia (HP:0002863)1.97346548
64Seborrheic dermatitis (HP:0001051)1.96074315
65Nephronophthisis (HP:0000090)1.95142474
66Atrophy/Degeneration involving motor neurons (HP:0007373)1.95056167
67Abnormal hair whorl (HP:0010721)1.94666203
68Male pseudohermaphroditism (HP:0000037)1.94525903
69Protruding tongue (HP:0010808)1.94378046
70Overfolded helix (HP:0000396)1.91720936
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90817477
72Abnormality of alanine metabolism (HP:0010916)1.90817477
73Hyperalaninemia (HP:0003348)1.90817477
74Sclerocornea (HP:0000647)1.90786526
75Poor coordination (HP:0002370)1.90264351
76IgM deficiency (HP:0002850)1.87149089
77Nephroblastoma (Wilms tumor) (HP:0002667)1.84821693
78Gonadotropin excess (HP:0000837)1.84196483
79Embryonal renal neoplasm (HP:0011794)1.83583695
80Spontaneous abortion (HP:0005268)1.83343227
81Abnormal pupillary function (HP:0007686)1.82390179
82Abnormality of midbrain morphology (HP:0002418)1.80660434
83Molar tooth sign on MRI (HP:0002419)1.80660434
84Abnormal mitochondria in muscle tissue (HP:0008316)1.78241932
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.77207329
86Pancytopenia (HP:0001876)1.76228139
87Polyphagia (HP:0002591)1.73454458
88Truncus arteriosus (HP:0001660)1.72072083
89Intestinal atresia (HP:0011100)1.70861838
90Tubulointerstitial nephritis (HP:0001970)1.69990886
91Myokymia (HP:0002411)1.69744155
92Impaired vibration sensation in the lower limbs (HP:0002166)1.69060403
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.68171539
94Atelectasis (HP:0100750)1.67275149
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.66890316
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66890316
97Progressive inability to walk (HP:0002505)1.66863560
98Hepatocellular necrosis (HP:0001404)1.66780233
99Aganglionic megacolon (HP:0002251)1.66177418
100Disproportionate short-trunk short stature (HP:0003521)1.65569479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K115.40842338
2MAP2K43.58042520
3WNK33.17896833
4BMPR1B2.06580018
5MAP3K52.02729951
6MAP3K1211.6521728
7VRK21.89145677
8CASK1.79288343
9PNCK1.62094578
10ZAK1.56611080
11NUAK11.56379436
12MARK31.54140347
13VRK11.39549370
14BUB11.35146182
15FRK1.34449705
16EPHA41.31966635
17BCKDK1.23912427
18DYRK21.18123009
19MKNK21.17591353
20TRIM281.16177456
21ACVR1B1.08922710
22NEK11.06839614
23MAP4K21.03257639
24TTK0.99568433
25MAPK130.98784100
26PLK30.95217770
27TSSK60.93752874
28MAP3K10.88153540
29PASK0.84769064
30CDC70.84660088
31PBK0.83794116
32FLT30.81649813
33ADRBK20.74708150
34MAP2K60.73080740
35TGFBR10.71049898
36MKNK10.69859081
37KSR10.68943245
38EIF2AK30.65952713
39DAPK10.65346207
40STK160.62199571
41STK110.60106956
42TNIK0.58751348
43EIF2AK20.57207893
44NTRK20.54335391
45WEE10.54144486
46MARK10.52657085
47DAPK20.52446027
48AKT30.52376503
49MAPKAPK30.49689323
50PLK40.49200760
51PRKCI0.46095014
52SGK20.45573890
53EIF2AK10.45501401
54YES10.44413159
55PIK3CA0.43298675
56ATR0.42721433
57SRPK10.40881541
58CDK80.40827899
59STK380.39340321
60ATM0.39043922
61PIM10.38971321
62MINK10.38783493
63RPS6KA50.37316858
64INSRR0.37152098
65BRSK20.36776092
66CAMK2A0.35227511
67DYRK1A0.34662002
68TEC0.33990332
69CCNB10.33957971
70KIT0.33890692
71PRKCE0.33877569
72PAK30.33314142
73GRK10.32983925
74PRKCG0.32889431
75CDK190.32774899
76PRKDC0.32594952
77DYRK30.32040849
78PDK20.31089836
79PLK10.31031468
80TXK0.29523704
81PLK20.29451140
82SGK10.29068154
83OXSR10.28278867
84PRKG10.26436346
85CDK90.26215019
86NME10.26101405
87CSNK1G20.25521782
88CSNK1G10.25403335
89JAK30.24870263
90STK40.24336623
91PRKACA0.23661854
92SGK2230.23626737
93SGK4940.23626737
94ALK0.23489869
95FES0.20083702
96OBSCN0.20063750
97AURKB0.19880700
98PRKCZ0.19802458
99CSNK1G30.17160377
100CHEK20.16803313

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67227285
2Mismatch repair_Homo sapiens_hsa034303.05726770
3Proteasome_Homo sapiens_hsa030502.91580167
4Propanoate metabolism_Homo sapiens_hsa006402.87500975
5Homologous recombination_Homo sapiens_hsa034402.73552102
6Non-homologous end-joining_Homo sapiens_hsa034502.71485646
7DNA replication_Homo sapiens_hsa030302.69206149
8Oxidative phosphorylation_Homo sapiens_hsa001902.68370040
9Parkinsons disease_Homo sapiens_hsa050122.64478213
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.09318931
11Protein export_Homo sapiens_hsa030602.06342440
12Pyruvate metabolism_Homo sapiens_hsa006201.95358876
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88168985
14Fanconi anemia pathway_Homo sapiens_hsa034601.77097867
15Fatty acid elongation_Homo sapiens_hsa000621.76417734
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69989912
17Huntingtons disease_Homo sapiens_hsa050161.63587548
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61819282
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57119936
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57091257
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52900332
22Alzheimers disease_Homo sapiens_hsa050101.52470299
23RNA degradation_Homo sapiens_hsa030181.49914967
24Lysine degradation_Homo sapiens_hsa003101.46420412
25Regulation of autophagy_Homo sapiens_hsa041401.46187912
26Morphine addiction_Homo sapiens_hsa050321.42221728
27Platelet activation_Homo sapiens_hsa046111.39350030
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38439293
29Taste transduction_Homo sapiens_hsa047421.37711311
30Serotonergic synapse_Homo sapiens_hsa047261.32388966
31Cardiac muscle contraction_Homo sapiens_hsa042601.29218807
32Basal transcription factors_Homo sapiens_hsa030221.26962962
33One carbon pool by folate_Homo sapiens_hsa006701.26933706
34GABAergic synapse_Homo sapiens_hsa047271.25112458
35Base excision repair_Homo sapiens_hsa034101.23484517
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23081312
37RNA polymerase_Homo sapiens_hsa030201.20669813
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19503371
39Glycerolipid metabolism_Homo sapiens_hsa005611.18334878
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15587852
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.15464161
42Collecting duct acid secretion_Homo sapiens_hsa049661.14108302
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14022185
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13858665
45Peroxisome_Homo sapiens_hsa041461.13337477
46Olfactory transduction_Homo sapiens_hsa047401.13206842
47Purine metabolism_Homo sapiens_hsa002301.09069836
48Arachidonic acid metabolism_Homo sapiens_hsa005901.07684418
49Tryptophan metabolism_Homo sapiens_hsa003801.00697353
50Nitrogen metabolism_Homo sapiens_hsa009100.92540459
51Phototransduction_Homo sapiens_hsa047440.91461670
52Cell cycle_Homo sapiens_hsa041100.87395559
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86817036
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85417222
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.85242087
56Hematopoietic cell lineage_Homo sapiens_hsa046400.84903050
57Nucleotide excision repair_Homo sapiens_hsa034200.83800858
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.83723692
59Chemical carcinogenesis_Homo sapiens_hsa052040.79938735
60Linoleic acid metabolism_Homo sapiens_hsa005910.77920077
61Circadian entrainment_Homo sapiens_hsa047130.75782660
62Histidine metabolism_Homo sapiens_hsa003400.72938872
63Selenocompound metabolism_Homo sapiens_hsa004500.72308509
64RNA transport_Homo sapiens_hsa030130.71642106
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70310532
66Spliceosome_Homo sapiens_hsa030400.70261105
67Glutathione metabolism_Homo sapiens_hsa004800.68045132
68ECM-receptor interaction_Homo sapiens_hsa045120.67605940
69Butanoate metabolism_Homo sapiens_hsa006500.66251628
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66171924
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65087388
72Fatty acid degradation_Homo sapiens_hsa000710.62583290
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61331116
74Retinol metabolism_Homo sapiens_hsa008300.61304684
75Arginine and proline metabolism_Homo sapiens_hsa003300.59664876
76Metabolic pathways_Homo sapiens_hsa011000.59612991
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57208589
78N-Glycan biosynthesis_Homo sapiens_hsa005100.55174342
79Tyrosine metabolism_Homo sapiens_hsa003500.52831342
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50064922
81Amphetamine addiction_Homo sapiens_hsa050310.47979059
82Fatty acid metabolism_Homo sapiens_hsa012120.45845186
83Dopaminergic synapse_Homo sapiens_hsa047280.42102058
84Ribosome_Homo sapiens_hsa030100.41849707
85Carbon metabolism_Homo sapiens_hsa012000.41682276
86Calcium signaling pathway_Homo sapiens_hsa040200.39406464
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38715305
88Oocyte meiosis_Homo sapiens_hsa041140.38096134
89Pyrimidine metabolism_Homo sapiens_hsa002400.37927554
90beta-Alanine metabolism_Homo sapiens_hsa004100.36150821
91Salivary secretion_Homo sapiens_hsa049700.32979201
92Insulin secretion_Homo sapiens_hsa049110.30068455
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29537538
94Fat digestion and absorption_Homo sapiens_hsa049750.28371083
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27809118
96Epstein-Barr virus infection_Homo sapiens_hsa051690.27611359
97Renin secretion_Homo sapiens_hsa049240.27353357
98Glutamatergic synapse_Homo sapiens_hsa047240.26401332
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26165208
100Systemic lupus erythematosus_Homo sapiens_hsa053220.25398359

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