SETP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of phospholipase A2 activity (GO:0032429)7.71120743
2regulation of cholesterol esterification (GO:0010872)6.82126663
3low-density lipoprotein particle remodeling (GO:0034374)5.23312837
4chromatin remodeling at centromere (GO:0031055)5.16856858
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.98338626
6CENP-A containing nucleosome assembly (GO:0034080)4.77166845
7rRNA methylation (GO:0031167)4.53585237
8regulation of Rac protein signal transduction (GO:0035020)4.47029693
9positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.34497168
10rRNA modification (GO:0000154)4.24237833
11histone exchange (GO:0043486)4.10478388
12water-soluble vitamin biosynthetic process (GO:0042364)3.85285715
13regulation of centriole replication (GO:0046599)3.82279077
14chaperone-mediated protein transport (GO:0072321)3.78140746
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.77742732
16positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.76056716
17translesion synthesis (GO:0019985)3.73709754
18DNA replication checkpoint (GO:0000076)3.70085262
19regulation of helicase activity (GO:0051095)3.67475127
20regulation of DNA endoreduplication (GO:0032875)3.64192290
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.44204255
22DNA replication-independent nucleosome organization (GO:0034724)3.40564091
23DNA replication-independent nucleosome assembly (GO:0006336)3.40564091
24aldehyde catabolic process (GO:0046185)3.38937793
25DNA ligation (GO:0006266)3.32222617
26purine nucleobase biosynthetic process (GO:0009113)3.28142349
27respiratory chain complex IV assembly (GO:0008535)3.27467396
28intraciliary transport (GO:0042073)3.18093206
29response to nitrosative stress (GO:0051409)3.16090334
30protein neddylation (GO:0045116)3.13348501
31regulation of type B pancreatic cell apoptotic process (GO:2000674)3.12890332
32magnesium ion transport (GO:0015693)3.08019701
33proteasome assembly (GO:0043248)3.05411682
34ventricular cardiac muscle cell development (GO:0055015)3.04984439
35postreplication repair (GO:0006301)3.04952406
36renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.01442692
37inner ear receptor cell development (GO:0060119)2.97744144
38platelet dense granule organization (GO:0060155)2.97352348
39protein K6-linked ubiquitination (GO:0085020)2.95617737
40centriole replication (GO:0007099)2.94477245
41regulation of mesoderm development (GO:2000380)2.93736762
42centrosome organization (GO:0051297)2.93391085
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92614281
44regulation of mitotic spindle checkpoint (GO:1903504)2.92614281
45cytochrome complex assembly (GO:0017004)2.90174245
46cullin deneddylation (GO:0010388)2.82719621
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82173269
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82173269
49iron-sulfur cluster assembly (GO:0016226)2.75633926
50metallo-sulfur cluster assembly (GO:0031163)2.75633926
51protein deneddylation (GO:0000338)2.74173903
52protein targeting to mitochondrion (GO:0006626)2.72607268
53branched-chain amino acid catabolic process (GO:0009083)2.72369946
54arginine catabolic process (GO:0006527)2.72313428
55nucleobase biosynthetic process (GO:0046112)2.71772451
56microtubule organizing center organization (GO:0031023)2.70664046
57protein complex biogenesis (GO:0070271)2.70444353
58DNA double-strand break processing (GO:0000729)2.69224500
59regulation of mitochondrial translation (GO:0070129)2.67409216
60establishment of integrated proviral latency (GO:0075713)2.66772149
61mitochondrial respiratory chain complex assembly (GO:0033108)2.65980725
62regulation of systemic arterial blood pressure (GO:0003073)2.57588676
63regulation of nuclear cell cycle DNA replication (GO:0033262)2.55278827
64establishment of protein localization to mitochondrion (GO:0072655)2.54649356
65spindle assembly involved in mitosis (GO:0090307)2.54646978
66regulation of renal sodium excretion (GO:0035813)2.53619556
67GMP metabolic process (GO:0046037)2.52477244
68protein localization to mitochondrion (GO:0070585)2.50959149
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.50829374
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.50829374
71negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50829374
72negative regulation of mitotic sister chromatid separation (GO:2000816)2.50829374
73negative regulation of sister chromatid segregation (GO:0033046)2.50829374
74regulation of systemic arterial blood pressure by hormone (GO:0001990)2.46714166
75regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.46714166
76endocrine process (GO:0050886)2.46714166
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46566114
78mitochondrial respiratory chain complex I assembly (GO:0032981)2.46566114
79NADH dehydrogenase complex assembly (GO:0010257)2.46566114
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46394943
81nonmotile primary cilium assembly (GO:0035058)2.45835779
82regulation of centrosome duplication (GO:0010824)2.45367646
83lactate metabolic process (GO:0006089)2.44565789
84nephron tubule morphogenesis (GO:0072078)2.44215949
85nephron epithelium morphogenesis (GO:0072088)2.44215949
86DNA replication-dependent nucleosome assembly (GO:0006335)2.44192180
87DNA replication-dependent nucleosome organization (GO:0034723)2.44192180
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43287611
89single strand break repair (GO:0000012)2.42501598
90negative regulation of chromosome segregation (GO:0051985)2.40148401
91mitotic G2/M transition checkpoint (GO:0044818)2.39015721
92mitotic metaphase plate congression (GO:0007080)2.39002267
93metaphase plate congression (GO:0051310)2.38902602
94replication fork processing (GO:0031297)2.38519068
95galactose catabolic process (GO:0019388)2.38417691
96ATP-dependent chromatin remodeling (GO:0043044)2.38070762
97kinetochore assembly (GO:0051382)2.38007913
98anterior/posterior axis specification, embryo (GO:0008595)2.37933282
99regulation of centrosome cycle (GO:0046605)2.37186949
100IMP biosynthetic process (GO:0006188)2.37052589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44348216
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.51610480
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.28315655
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.93241794
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.82994884
6IGF1R_20145208_ChIP-Seq_DFB_Human2.72352615
7ELK1_19687146_ChIP-ChIP_HELA_Human2.56594422
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55338215
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54346347
10VDR_22108803_ChIP-Seq_LS180_Human2.47937836
11E2F7_22180533_ChIP-Seq_HELA_Human2.45491061
12FUS_26573619_Chip-Seq_HEK293_Human2.43447881
13TAF15_26573619_Chip-Seq_HEK293_Human2.42692411
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33842848
15ZNF274_21170338_ChIP-Seq_K562_Hela2.29230190
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28944038
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12494752
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11262694
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.05633509
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02691636
21PIAS1_25552417_ChIP-Seq_VCAP_Human2.02456015
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01071540
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00853985
24EWS_26573619_Chip-Seq_HEK293_Human1.98946750
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96349287
26P300_19829295_ChIP-Seq_ESCs_Human1.82027232
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78061264
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76994940
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.74604844
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73789482
31NANOG_16153702_ChIP-ChIP_HESCs_Human1.70861333
32VDR_23849224_ChIP-Seq_CD4+_Human1.70192497
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.69631243
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.67530180
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65775950
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.61907629
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58498411
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57881652
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.57086609
40GBX2_23144817_ChIP-Seq_PC3_Human1.55942237
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53778171
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52114873
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48967117
44LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45241472
45MYC_18940864_ChIP-ChIP_HL60_Human1.42686784
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35399343
47FOXP3_21729870_ChIP-Seq_TREG_Human1.35208653
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.34034369
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33341173
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31377263
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31118276
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30279516
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30161894
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29200098
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28653798
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28250785
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23882186
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22418965
59HTT_18923047_ChIP-ChIP_STHdh_Human1.19736165
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16701795
61IRF1_19129219_ChIP-ChIP_H3396_Human1.16631668
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16580459
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15819424
64GABP_19822575_ChIP-Seq_HepG2_Human1.14742199
65ER_23166858_ChIP-Seq_MCF-7_Human1.14039128
66TTF2_22483619_ChIP-Seq_HELA_Human1.13929948
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13036816
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12234363
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.12089230
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12081710
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11782141
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.10809943
73TP53_22573176_ChIP-Seq_HFKS_Human1.06309789
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06014314
75STAT3_23295773_ChIP-Seq_U87_Human1.04104543
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03377597
77AR_21909140_ChIP-Seq_LNCAP_Human1.03217049
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01946105
79SMAD4_21799915_ChIP-Seq_A2780_Human1.01171543
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00769694
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00074219
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99543014
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98030594
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.97571392
85JUN_21703547_ChIP-Seq_K562_Human0.95812952
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94072012
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93040647
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91851779
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91709733
90SMAD3_21741376_ChIP-Seq_EPCs_Human0.91211124
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89323860
92SOX2_19829295_ChIP-Seq_ESCs_Human0.88481272
93NANOG_19829295_ChIP-Seq_ESCs_Human0.88481272
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87816538
95AR_25329375_ChIP-Seq_VCAP_Human0.86923327
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86070389
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85985142
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85817336
99CBP_20019798_ChIP-Seq_JUKART_Human0.84466217
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84466217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.60387293
2MP0003122_maternal_imprinting3.20854392
3MP0006072_abnormal_retinal_apoptosis3.06159833
4MP0005423_abnormal_somatic_nervous2.90656966
5MP0008057_abnormal_DNA_replication2.82516433
6MP0002102_abnormal_ear_morphology2.76552516
7MP0003693_abnormal_embryo_hatching2.64793137
8MP0010094_abnormal_chromosome_stability2.57935823
9MP0001984_abnormal_olfaction2.32818710
10MP0008058_abnormal_DNA_repair2.31782189
11MP0002653_abnormal_ependyma_morphology2.23316658
12MP0004133_heterotaxia2.20286853
13MP0008877_abnormal_DNA_methylation2.02103044
14MP0003567_abnormal_fetal_cardiomyocyte2.00445741
15MP0001529_abnormal_vocalization1.99706884
16MP0001293_anophthalmia1.96110381
17MP0008007_abnormal_cellular_replicative1.88308945
18MP0009384_cardiac_valve_regurgitation1.87784317
19MP0002160_abnormal_reproductive_system1.87772680
20MP0005084_abnormal_gallbladder_morpholo1.85419248
21MP0002837_dystrophic_cardiac_calcinosis1.84136458
22MP0003786_premature_aging1.73016850
23MP0006035_abnormal_mitochondrial_morpho1.67029951
24MP0001764_abnormal_homeostasis1.65068917
25MP0003937_abnormal_limbs/digits/tail_de1.63553083
26MP0003111_abnormal_nucleus_morphology1.61279164
27MP0002751_abnormal_autonomic_nervous1.60017283
28MP0003283_abnormal_digestive_organ1.56558812
29MP0005379_endocrine/exocrine_gland_phen1.55991704
30MP0006292_abnormal_olfactory_placode1.54795458
31MP0003136_yellow_coat_color1.52590220
32MP0005389_reproductive_system_phenotype1.51942888
33MP0004215_abnormal_myocardial_fiber1.50686317
34MP0008932_abnormal_embryonic_tissue1.50071685
35MP0003186_abnormal_redox_activity1.48821783
36MP0003077_abnormal_cell_cycle1.46513944
37MP0001286_abnormal_eye_development1.44380699
38MP0001299_abnormal_eye_distance/1.35866063
39MP0000383_abnormal_hair_follicle1.30345694
40MP0005377_hearing/vestibular/ear_phenot1.29037958
41MP0003878_abnormal_ear_physiology1.29037958
42MP0000049_abnormal_middle_ear1.28996851
43MP0001919_abnormal_reproductive_system1.28531511
44MP0002697_abnormal_eye_size1.27989127
45MP0005253_abnormal_eye_physiology1.26713756
46MP0008775_abnormal_heart_ventricle1.26507507
47MP0002090_abnormal_vision1.26219843
48MP0006036_abnormal_mitochondrial_physio1.25711968
49MP0008789_abnormal_olfactory_epithelium1.25194668
50MP0002938_white_spotting1.21542930
51MP0003137_abnormal_impulse_conducting1.20397782
52MP0000647_abnormal_sebaceous_gland1.17462709
53MP0001968_abnormal_touch/_nociception1.16061683
54MP0000358_abnormal_cell_content/1.12681601
55MP0002736_abnormal_nociception_after1.12519833
56MP0002163_abnormal_gland_morphology1.12205803
57MP0010030_abnormal_orbit_morphology1.10935119
58MP0003121_genomic_imprinting1.05631500
59MP0001188_hyperpigmentation1.05534365
60MP0004270_analgesia1.04568880
61MP0005391_vision/eye_phenotype1.03237338
62MP0009697_abnormal_copulation1.02883208
63MP0005595_abnormal_vascular_smooth1.02454438
64MP0001485_abnormal_pinna_reflex1.01045620
65MP0005220_abnormal_exocrine_pancreas0.99515422
66MP0003755_abnormal_palate_morphology0.96342323
67MP0004197_abnormal_fetal_growth/weight/0.93969586
68MP0003123_paternal_imprinting0.93723071
69MP0002233_abnormal_nose_morphology0.92825007
70MP0004085_abnormal_heartbeat0.89987228
71MP0002877_abnormal_melanocyte_morpholog0.89829700
72MP0000350_abnormal_cell_proliferation0.89772281
73MP0002734_abnormal_mechanical_nocicepti0.88963481
74MP0000631_abnormal_neuroendocrine_gland0.88511147
75MP0005620_abnormal_muscle_contractility0.88019592
76MP0005332_abnormal_amino_acid0.87214150
77MP0001177_atelectasis0.86969281
78MP0000427_abnormal_hair_cycle0.86536511
79MP0005623_abnormal_meninges_morphology0.83253748
80MP0002254_reproductive_system_inflammat0.83110591
81MP0005195_abnormal_posterior_eye0.83033597
82MP0002638_abnormal_pupillary_reflex0.82946979
83MP0004019_abnormal_vitamin_homeostasis0.82858134
84MP0004957_abnormal_blastocyst_morpholog0.80665095
85MP0000579_abnormal_nail_morphology0.78867695
86MP0003942_abnormal_urinary_system0.78378690
87MP0002177_abnormal_outer_ear0.77401115
88MP0002092_abnormal_eye_morphology0.76791001
89MP0004147_increased_porphyrin_level0.74059626
90MP0003119_abnormal_digestive_system0.73536577
91MP0002009_preneoplasia0.73484158
92MP0002111_abnormal_tail_morphology0.71060178
93MP0001929_abnormal_gametogenesis0.70552919
94MP0001119_abnormal_female_reproductive0.70064235
95MP0003718_maternal_effect0.68625426
96MP0000653_abnormal_sex_gland0.64476337
97MP0005551_abnormal_eye_electrophysiolog0.64186862
98MP0002972_abnormal_cardiac_muscle0.63099806
99MP0001340_abnormal_eyelid_morphology0.60197141
100MP0001145_abnormal_male_reproductive0.60158238

Predicted human phenotypes

RankGene SetZ-score
1Potter facies (HP:0002009)6.37119447
2Facial shape deformation (HP:0011334)6.37119447
3Widely patent fontanelles and sutures (HP:0004492)4.35498426
4True hermaphroditism (HP:0010459)3.78861541
5Pancreatic cysts (HP:0001737)3.78683508
6Pancreatic fibrosis (HP:0100732)3.42915287
7Pancreatic islet-cell hyperplasia (HP:0004510)3.22414165
8Colon cancer (HP:0003003)3.22262012
9Abnormality of the labia minora (HP:0012880)3.18238804
10Hyperglycinemia (HP:0002154)3.10172025
11Hydroureter (HP:0000072)3.07250361
12Abnormality of renal excretion (HP:0011036)3.05905260
13Abnormality of the pancreatic islet cells (HP:0006476)2.90084059
14Abnormality of endocrine pancreas physiology (HP:0012093)2.90084059
15Wide cranial sutures (HP:0010537)2.87921696
16Hyperinsulinemic hypoglycemia (HP:0000825)2.74621816
17Abnormal urine output (HP:0012590)2.74608376
18Chronic hepatic failure (HP:0100626)2.74583587
19Cystic liver disease (HP:0006706)2.74400808
20Occipital encephalocele (HP:0002085)2.71381893
21Urethral obstruction (HP:0000796)2.56335004
22Methylmalonic aciduria (HP:0012120)2.53212990
23Abnormality of urine glucose concentration (HP:0011016)2.51288020
24Glycosuria (HP:0003076)2.51288020
25Poor head control (HP:0002421)2.50357825
26Meckel diverticulum (HP:0002245)2.48931093
27Abnormality of the ileum (HP:0001549)2.46371730
28Abnormality of midbrain morphology (HP:0002418)2.45304740
29Molar tooth sign on MRI (HP:0002419)2.45304740
30Oligohydramnios (HP:0001562)2.43228776
31Sclerocornea (HP:0000647)2.42572968
32Hypoglycemic seizures (HP:0002173)2.41901797
33Congenital hepatic fibrosis (HP:0002612)2.35985498
34Hyperglycinuria (HP:0003108)2.35768873
35Medial flaring of the eyebrow (HP:0010747)2.35520031
36Abnormality of serine family amino acid metabolism (HP:0010894)2.33852971
37Abnormality of glycine metabolism (HP:0010895)2.33852971
38Methylmalonic acidemia (HP:0002912)2.33079939
39Abolished electroretinogram (ERG) (HP:0000550)2.31678286
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.29658436
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28741270
42Multifactorial inheritance (HP:0001426)2.26419748
43Short hallux (HP:0010109)2.23951245
44Type II lissencephaly (HP:0007260)2.21333330
45Absent epiphyses (HP:0010577)2.21312404
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.21312404
47Supernumerary spleens (HP:0009799)2.16893492
48Pendular nystagmus (HP:0012043)2.15769064
49Chromsome breakage (HP:0040012)2.14021627
50Congenital primary aphakia (HP:0007707)2.13112192
51Septo-optic dysplasia (HP:0100842)2.09161947
52Postaxial foot polydactyly (HP:0001830)2.08673072
53Preaxial hand polydactyly (HP:0001177)2.07908531
54Aplasia/Hypoplasia of the hallux (HP:0008362)2.07552504
55Cerebellar dysplasia (HP:0007033)2.06495094
56Bifid tongue (HP:0010297)2.03947444
57Abnormality of serum amino acid levels (HP:0003112)2.03067613
58Gait imbalance (HP:0002141)2.01945833
59Acute necrotizing encephalopathy (HP:0006965)2.01349425
60Preaxial foot polydactyly (HP:0001841)2.01335119
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00010447
62Nephrogenic diabetes insipidus (HP:0009806)1.98228684
63Vaginal atresia (HP:0000148)1.96819927
64Disproportionate short-trunk short stature (HP:0003521)1.96784290
65Intestinal atresia (HP:0011100)1.95775802
66Anencephaly (HP:0002323)1.95209407
67Acute encephalopathy (HP:0006846)1.93081276
68Oligodactyly (hands) (HP:0001180)1.91100236
69Osteomalacia (HP:0002749)1.89960991
70Postnatal microcephaly (HP:0005484)1.89922261
71Retinal dysplasia (HP:0007973)1.89899544
723-Methylglutaconic aciduria (HP:0003535)1.87903183
73Genital tract atresia (HP:0001827)1.87744942
74Nephronophthisis (HP:0000090)1.86735283
75Abnormality of the proximal phalanges of the hand (HP:0009834)1.86285666
76Abnormal biliary tract physiology (HP:0012439)1.85951996
77Bile duct proliferation (HP:0001408)1.85951996
78Biliary tract neoplasm (HP:0100574)1.84245861
79Abnormality of chromosome stability (HP:0003220)1.83488726
80Hyperphosphaturia (HP:0003109)1.81102423
81Pulmonary hypoplasia (HP:0002089)1.80025919
82Abnormality of the preputium (HP:0100587)1.78816125
83Hypoglycemic coma (HP:0001325)1.77880832
84Optic nerve coloboma (HP:0000588)1.77619732
85Exercise-induced muscle cramps (HP:0003710)1.76453962
86Abnormal mitochondria in muscle tissue (HP:0008316)1.75905020
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.75407819
88Abnormality of methionine metabolism (HP:0010901)1.75226862
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74388978
90Sloping forehead (HP:0000340)1.74178606
91Hyperventilation (HP:0002883)1.73282775
92Furrowed tongue (HP:0000221)1.71125359
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67694712
94Hypoplastic pelvis (HP:0008839)1.67603355
95Large for gestational age (HP:0001520)1.67521679
96Barrel-shaped chest (HP:0001552)1.67395657
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67383863
98Aplasia/hypoplasia of the uterus (HP:0008684)1.67200272
99Male pseudohermaphroditism (HP:0000037)1.67079149
100Progressive macrocephaly (HP:0004481)1.65800383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K73.43824264
2PLK43.31004780
3MAP3K43.15890862
4MAP3K63.08008923
5ZAK2.87309834
6CDC72.71726715
7MKNK22.32784866
8NEK12.22528285
9TAF12.21413694
10WNK32.18911545
11TTK2.16402047
12MKNK12.08489200
13PLK32.04474917
14NUAK12.02456336
15SRPK12.00916843
16DYRK31.93970639
17TIE11.88029720
18EPHB11.87441388
19VRK21.79852610
20WEE11.72585764
21TNIK1.70767372
22PBK1.63620994
23BMPR1B1.62831599
24PASK1.59894924
25PLK21.57850632
26BCKDK1.57671947
27VRK11.54892745
28LIMK11.53674769
29MST41.51856478
30BRSK11.51807585
31BRSK21.46521855
32TSSK61.46151626
33EIF2AK11.40670889
34CCNB11.33858149
35PLK11.31980451
36NEK91.25486494
37PAK31.25241160
38NME11.24302943
39PIK3CG1.20926917
40STK38L1.16905114
41PNCK1.13494455
42DAPK21.10726339
43TRIM281.06924952
44PINK11.05980129
45CHEK21.02819377
46DYRK20.98006560
47MAP2K40.96748492
48GRK10.94854803
49AURKB0.92503894
50BUB10.92429138
51MAP3K50.90905197
52ADRBK20.90472718
53STK40.89293380
54RPS6KA40.88697227
55ACVR1B0.86151519
56FRK0.86141561
57EIF2AK30.84392370
58STK160.80527146
59ATR0.78455537
60CSNK1G10.74822148
61STK30.74373752
62PRKCE0.73800297
63ERBB30.69950654
64STK240.68408756
65CASK0.67446410
66ERBB40.62456789
67DAPK10.60148009
68MAPKAPK50.59993096
69CDK190.59259323
70DYRK1A0.57754149
71NEK20.56505896
72TGFBR10.56333922
73MAPK130.56056086
74CSNK1G20.55735837
75ATM0.55441491
76CHEK10.55087308
77OXSR10.54918933
78CAMK2D0.54603704
79PRKCI0.53997881
80PRKCG0.53776656
81NEK60.52646942
82MUSK0.52622009
83CSNK1G30.47337307
84CDK30.47043553
85PTK2B0.46783976
86CDK70.46265201
87MELK0.42831278
88MAP2K60.42433976
89MAPK150.40206166
90BCR0.40081760
91PDK20.39504402
92CSNK2A10.36912040
93CDK180.35902947
94CSNK1A1L0.34866275
95CDK11A0.33804253
96CDK150.32641391
97INSRR0.32223404
98OBSCN0.32045729
99TESK10.30164478
100RPS6KA50.29985292

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.95942101
2Homologous recombination_Homo sapiens_hsa034402.80100282
3Propanoate metabolism_Homo sapiens_hsa006402.78893379
4Proteasome_Homo sapiens_hsa030502.75660197
5Mismatch repair_Homo sapiens_hsa034302.66462668
6Renin-angiotensin system_Homo sapiens_hsa046142.52110289
7DNA replication_Homo sapiens_hsa030302.38332973
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36303873
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23517286
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17342619
11Fanconi anemia pathway_Homo sapiens_hsa034602.10196923
12RNA polymerase_Homo sapiens_hsa030201.97553245
13Oxidative phosphorylation_Homo sapiens_hsa001901.90171788
14Vitamin B6 metabolism_Homo sapiens_hsa007501.87246894
15Folate biosynthesis_Homo sapiens_hsa007901.85614413
16Base excision repair_Homo sapiens_hsa034101.79301250
17Butanoate metabolism_Homo sapiens_hsa006501.74512243
18One carbon pool by folate_Homo sapiens_hsa006701.72842870
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67556664
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66300867
21Tryptophan metabolism_Homo sapiens_hsa003801.57927447
22Parkinsons disease_Homo sapiens_hsa050121.55388079
23RNA degradation_Homo sapiens_hsa030181.50276209
24Spliceosome_Homo sapiens_hsa030401.49987843
25RNA transport_Homo sapiens_hsa030131.49035738
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.47944817
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46937134
28Arginine and proline metabolism_Homo sapiens_hsa003301.42902232
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40131550
30Regulation of autophagy_Homo sapiens_hsa041401.36881863
31Nucleotide excision repair_Homo sapiens_hsa034201.34920812
32beta-Alanine metabolism_Homo sapiens_hsa004101.34727901
33Pyruvate metabolism_Homo sapiens_hsa006201.34430942
34Basal transcription factors_Homo sapiens_hsa030221.31842577
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29582742
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25189199
37Nitrogen metabolism_Homo sapiens_hsa009101.23160598
38Non-homologous end-joining_Homo sapiens_hsa034501.19920331
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16303786
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15145110
41Pyrimidine metabolism_Homo sapiens_hsa002401.12231158
42Purine metabolism_Homo sapiens_hsa002301.11302311
43Sulfur metabolism_Homo sapiens_hsa009201.05325177
44Huntingtons disease_Homo sapiens_hsa050161.05105940
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04927626
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.04668121
47Peroxisome_Homo sapiens_hsa041461.03331457
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01688630
49Cell cycle_Homo sapiens_hsa041101.00906223
50Galactose metabolism_Homo sapiens_hsa000520.97310821
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.94782055
52Glutathione metabolism_Homo sapiens_hsa004800.91295282
53Fatty acid degradation_Homo sapiens_hsa000710.90309817
54Ribosome_Homo sapiens_hsa030100.88839989
55Collecting duct acid secretion_Homo sapiens_hsa049660.87351115
56Steroid biosynthesis_Homo sapiens_hsa001000.86724481
57Alzheimers disease_Homo sapiens_hsa050100.85662714
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85169371
59Carbon metabolism_Homo sapiens_hsa012000.84589987
60Metabolic pathways_Homo sapiens_hsa011000.82832165
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81205790
62Fatty acid elongation_Homo sapiens_hsa000620.79756598
63TGF-beta signaling pathway_Homo sapiens_hsa043500.77614049
64Starch and sucrose metabolism_Homo sapiens_hsa005000.75433033
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74189812
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74124724
67Biosynthesis of amino acids_Homo sapiens_hsa012300.73914938
68p53 signaling pathway_Homo sapiens_hsa041150.73752122
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71405309
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69009055
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63535745
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63209889
73Linoleic acid metabolism_Homo sapiens_hsa005910.63139089
74Sulfur relay system_Homo sapiens_hsa041220.61934287
75Retinol metabolism_Homo sapiens_hsa008300.61647771
76Mineral absorption_Homo sapiens_hsa049780.61042163
77Selenocompound metabolism_Homo sapiens_hsa004500.59508958
78N-Glycan biosynthesis_Homo sapiens_hsa005100.57282356
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55566634
80Phototransduction_Homo sapiens_hsa047440.55025016
81Basal cell carcinoma_Homo sapiens_hsa052170.54588754
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54520468
83Caffeine metabolism_Homo sapiens_hsa002320.50663086
84Chemical carcinogenesis_Homo sapiens_hsa052040.49999908
85Histidine metabolism_Homo sapiens_hsa003400.49734634
86Serotonergic synapse_Homo sapiens_hsa047260.48857524
87Renin secretion_Homo sapiens_hsa049240.48001732
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47596207
89Vibrio cholerae infection_Homo sapiens_hsa051100.46652671
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46091111
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42699398
92Hippo signaling pathway_Homo sapiens_hsa043900.42439959
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41572606
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.41195385
95Wnt signaling pathway_Homo sapiens_hsa043100.40911019
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39487617
97Oocyte meiosis_Homo sapiens_hsa041140.39174257
98mRNA surveillance pathway_Homo sapiens_hsa030150.36883706
99Cardiac muscle contraction_Homo sapiens_hsa042600.36820321
100Fatty acid metabolism_Homo sapiens_hsa012120.36409829

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