SETP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA endoreduplication (GO:0032875)5.56769740
2establishment of integrated proviral latency (GO:0075713)5.19395205
3CENP-A containing nucleosome assembly (GO:0034080)5.04553150
4chromatin remodeling at centromere (GO:0031055)5.03205707
5formation of translation preinitiation complex (GO:0001731)4.76892019
6proteasome assembly (GO:0043248)4.57967160
7transcription from mitochondrial promoter (GO:0006390)4.56231868
8ribosome assembly (GO:0042255)4.46932133
9DNA strand elongation involved in DNA replication (GO:0006271)4.44721329
10histone exchange (GO:0043486)4.39618939
11mitochondrial RNA metabolic process (GO:0000959)4.38284161
12negative regulation of DNA-dependent DNA replication (GO:2000104)4.32472947
13DNA replication-dependent nucleosome assembly (GO:0006335)4.29025593
14DNA replication-dependent nucleosome organization (GO:0034723)4.29025593
15DNA strand elongation (GO:0022616)4.17666099
16DNA replication-independent nucleosome assembly (GO:0006336)4.08521426
17DNA replication-independent nucleosome organization (GO:0034724)4.08521426
18establishment of viral latency (GO:0019043)3.88625118
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.87477769
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.83195321
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.83195321
22spliceosomal snRNP assembly (GO:0000387)3.79609475
23termination of RNA polymerase II transcription (GO:0006369)3.70836965
24DNA replication checkpoint (GO:0000076)3.67843824
25telomere maintenance via semi-conservative replication (GO:0032201)3.67556227
26regulation of helicase activity (GO:0051095)3.66547641
27DNA ligation (GO:0006266)3.64858005
28DNA replication initiation (GO:0006270)3.64146394
29positive regulation of cellular response to oxidative stress (GO:1900409)3.60591444
30positive regulation of response to oxidative stress (GO:1902884)3.60591444
31mitotic metaphase plate congression (GO:0007080)3.58911728
32pseudouridine synthesis (GO:0001522)3.58751172
33protein localization to kinetochore (GO:0034501)3.58022610
34cullin deneddylation (GO:0010388)3.55595664
35histone mRNA metabolic process (GO:0008334)3.49039031
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.47899253
37protein deneddylation (GO:0000338)3.45718664
38regulation of centriole replication (GO:0046599)3.40715759
39maturation of 5.8S rRNA (GO:0000460)3.35150024
40metaphase plate congression (GO:0051310)3.32613621
41ribosome biogenesis (GO:0042254)3.30685125
42rRNA modification (GO:0000154)3.28981786
43telomere maintenance via recombination (GO:0000722)3.28315041
44L-serine metabolic process (GO:0006563)3.27777350
45mRNA splicing, via spliceosome (GO:0000398)3.27552026
46RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.27552026
47ATP-dependent chromatin remodeling (GO:0043044)3.27003212
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.25050805
49RNA splicing, via transesterification reactions (GO:0000375)3.24537437
50DNA-templated transcription, termination (GO:0006353)3.23592662
51DNA double-strand break processing (GO:0000729)3.21992325
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19909750
53kinetochore organization (GO:0051383)3.19708481
54cilium or flagellum-dependent cell motility (GO:0001539)3.19258621
55mitotic recombination (GO:0006312)3.16702444
56double-strand break repair via nonhomologous end joining (GO:0006303)3.10937281
57non-recombinational repair (GO:0000726)3.10937281
58chaperone-mediated protein transport (GO:0072321)3.07505239
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.06852759
60termination of RNA polymerase III transcription (GO:0006386)3.06852759
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06506357
62negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.03792748
63tRNA methylation (GO:0030488)3.03609449
64regulation of transcription from RNA polymerase I promoter (GO:0006356)3.03205444
65regulation of nuclear cell cycle DNA replication (GO:0033262)3.00929308
66tRNA aminoacylation for protein translation (GO:0006418)3.00034295
67DNA topological change (GO:0006265)2.99961246
68DNA unwinding involved in DNA replication (GO:0006268)2.97254018
69negative regulation of RNA splicing (GO:0033119)2.96549534
70regulation of oxidative stress-induced neuron death (GO:1903203)2.95720954
71rRNA processing (GO:0006364)2.95594535
72regulation of double-strand break repair via homologous recombination (GO:0010569)2.94892533
73regulation of mitochondrial translation (GO:0070129)2.93929924
74nucleotide-excision repair, DNA gap filling (GO:0006297)2.92092188
75negative regulation of mRNA processing (GO:0050686)2.91550252
76mitochondrial respiratory chain complex assembly (GO:0033108)2.91055865
77postreplication repair (GO:0006301)2.90428056
78tRNA aminoacylation (GO:0043039)2.89506249
79amino acid activation (GO:0043038)2.89506249
80telomere maintenance via telomere lengthening (GO:0010833)2.88832247
81chromatin assembly or disassembly (GO:0006333)2.88135550
82regulation of DNA-dependent DNA replication (GO:0090329)2.84891860
83somatic diversification of immunoglobulins (GO:0016445)2.83774539
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83516307
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82993367
86isotype switching (GO:0045190)2.82993367
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82993367
88somatic recombination of immunoglobulin gene segments (GO:0016447)2.81932026
89DNA deamination (GO:0045006)2.81920071
90rRNA metabolic process (GO:0016072)2.81181142
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80094861
92purine nucleobase biosynthetic process (GO:0009113)2.79287439
93regulation of mitotic spindle checkpoint (GO:1903504)2.79134971
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79134971
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78049530
96DNA damage response, detection of DNA damage (GO:0042769)2.77869715
97kinetochore assembly (GO:0051382)2.77567811
98protein localization to chromosome, centromeric region (GO:0071459)2.77173045
99ribonucleoprotein complex assembly (GO:0022618)2.76020747
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74201410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93120308
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43979310
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04691537
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.93850085
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76254848
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.47523957
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.24694733
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04049883
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.89429202
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.84569916
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.79389666
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77609711
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74051929
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71457269
15ELK1_19687146_ChIP-ChIP_HELA_Human2.69760241
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59558923
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58764756
18VDR_23849224_ChIP-Seq_CD4+_Human2.53233467
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44781967
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39721831
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39511143
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37662034
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35960549
24FOXP3_21729870_ChIP-Seq_TREG_Human2.30648778
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.22761983
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20038549
27YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15706005
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10699702
29PADI4_21655091_ChIP-ChIP_MCF-7_Human2.01252298
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95460399
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90698191
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.84372369
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81709265
34TTF2_22483619_ChIP-Seq_HELA_Human1.81198974
35AR_21909140_ChIP-Seq_LNCAP_Human1.81156804
36IGF1R_20145208_ChIP-Seq_DFB_Human1.78792944
37GABP_19822575_ChIP-Seq_HepG2_Human1.75243314
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74826035
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74465640
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73801238
41DCP1A_22483619_ChIP-Seq_HELA_Human1.73652518
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73110406
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.69764084
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.68326993
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68263803
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67723080
47EWS_26573619_Chip-Seq_HEK293_Human1.62064509
48XRN2_22483619_ChIP-Seq_HELA_Human1.60439784
49MYC_18940864_ChIP-ChIP_HL60_Human1.59019058
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58848665
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56405642
52VDR_22108803_ChIP-Seq_LS180_Human1.54159293
53ZNF274_21170338_ChIP-Seq_K562_Hela1.45054053
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42604558
55IRF1_19129219_ChIP-ChIP_H3396_Human1.38326223
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37645817
57FUS_26573619_Chip-Seq_HEK293_Human1.35732909
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.34180003
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31258701
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29437217
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27611280
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.26130006
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22140972
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21930648
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.15806570
66CIITA_25753668_ChIP-Seq_RAJI_Human1.10989511
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.10478304
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08425311
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07580715
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05882060
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05844474
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05008470
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02785314
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01696485
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00119036
76KDM5A_27292631_Chip-Seq_BREAST_Human0.99547304
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96016713
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90829141
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88616596
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86920913
81SOX17_20123909_ChIP-Seq_XEN_Mouse0.84151792
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84092016
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83663774
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82693822
85TP53_22573176_ChIP-Seq_HFKS_Human0.75553160
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.73338864
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73195200
88ELF5_23300383_ChIP-Seq_T47D_Human0.73032817
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72291468
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72090563
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71754462
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.70793588
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69343084
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68012486
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.67868776
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67864982
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.67784149
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.67507964
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67444767
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.66338771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.08315286
2MP0010094_abnormal_chromosome_stability4.73734262
3MP0008007_abnormal_cellular_replicative3.98637537
4MP0003693_abnormal_embryo_hatching3.71928679
5MP0004957_abnormal_blastocyst_morpholog3.66008118
6MP0008058_abnormal_DNA_repair3.57627368
7MP0003111_abnormal_nucleus_morphology3.54693000
8MP0009697_abnormal_copulation3.03565232
9MP0008057_abnormal_DNA_replication2.87081919
10MP0003077_abnormal_cell_cycle2.86636104
11MP0003806_abnormal_nucleotide_metabolis2.33649780
12MP0003136_yellow_coat_color2.26062967
13MP0008877_abnormal_DNA_methylation2.08975338
14MP0001730_embryonic_growth_arrest2.04814777
15MP0001293_anophthalmia2.02961465
16MP0003718_maternal_effect2.00225584
17MP0008932_abnormal_embryonic_tissue1.98084299
18MP0003786_premature_aging1.84804572
19MP0000350_abnormal_cell_proliferation1.83867194
20MP0003941_abnormal_skin_development1.72536435
21MP0003315_abnormal_perineum_morphology1.70145393
22MP0006035_abnormal_mitochondrial_morpho1.65977158
23MP0001188_hyperpigmentation1.65140384
24MP0005187_abnormal_penis_morphology1.64370638
25MP0006036_abnormal_mitochondrial_physio1.62088645
26MP0001697_abnormal_embryo_size1.56155834
27MP0002085_abnormal_embryonic_tissue1.55258189
28MP0009379_abnormal_foot_pigmentation1.54314532
29MP0002234_abnormal_pharynx_morphology1.53803636
30MP0006072_abnormal_retinal_apoptosis1.53482890
31MP0002938_white_spotting1.44777358
32MP0003937_abnormal_limbs/digits/tail_de1.42128386
33MP0004133_heterotaxia1.40025936
34MP0005380_embryogenesis_phenotype1.38810729
35MP0001672_abnormal_embryogenesis/_devel1.38810729
36MP0002084_abnormal_developmental_patter1.38689668
37MP0005084_abnormal_gallbladder_morpholo1.38663561
38MP0003186_abnormal_redox_activity1.37686888
39MP0000647_abnormal_sebaceous_gland1.36553587
40MP0003984_embryonic_growth_retardation1.35824239
41MP0000313_abnormal_cell_death1.33758537
42MP0002088_abnormal_embryonic_growth/wei1.31914635
43MP0002396_abnormal_hematopoietic_system1.29218457
44MP0002080_prenatal_lethality1.27617507
45MP0004808_abnormal_hematopoietic_stem1.25386416
46MP0000358_abnormal_cell_content/1.23004542
47MP0003567_abnormal_fetal_cardiomyocyte1.22776523
48MP0000428_abnormal_craniofacial_morphol1.20792356
49MP0005174_abnormal_tail_pigmentation1.17306415
50MP0002277_abnormal_respiratory_mucosa1.17049289
51MP0000049_abnormal_middle_ear1.13063071
52MP0001286_abnormal_eye_development1.11957591
53MP0004197_abnormal_fetal_growth/weight/1.11773293
54MP0002254_reproductive_system_inflammat1.10851488
55MP0002160_abnormal_reproductive_system1.01840486
56MP0000372_irregular_coat_pigmentation1.01635518
57MP0002653_abnormal_ependyma_morphology1.01261733
58MP0002233_abnormal_nose_morphology1.00481828
59MP0001929_abnormal_gametogenesis1.00390457
60MP0002210_abnormal_sex_determination1.00287056
61MP0000569_abnormal_digit_pigmentation0.98832030
62MP0009672_abnormal_birth_weight0.96546917
63MP0000653_abnormal_sex_gland0.95000827
64MP0008789_abnormal_olfactory_epithelium0.94006637
65MP0005253_abnormal_eye_physiology0.93185553
66MP0001145_abnormal_male_reproductive0.93082158
67MP0000678_abnormal_parathyroid_gland0.92527356
68MP0005408_hypopigmentation0.90016814
69MP0008995_early_reproductive_senescence0.89230808
70MP0001177_atelectasis0.87137070
71MP0010352_gastrointestinal_tract_polyps0.86227884
72MP0003890_abnormal_embryonic-extraembry0.85044117
73MP0003861_abnormal_nervous_system0.82216187
74MP0002111_abnormal_tail_morphology0.80519045
75MP0005391_vision/eye_phenotype0.80449282
76MP0001661_extended_life_span0.78512167
77MP0002019_abnormal_tumor_incidence0.78446695
78MP0002697_abnormal_eye_size0.77343063
79MP0000631_abnormal_neuroendocrine_gland0.76674791
80MP0002282_abnormal_trachea_morphology0.74993788
81MP0002086_abnormal_extraembryonic_tissu0.74939290
82MP0003698_abnormal_male_reproductive0.74228051
83MP0005389_reproductive_system_phenotype0.74078726
84MP0005220_abnormal_exocrine_pancreas0.73543404
85MP0001346_abnormal_lacrimal_gland0.73204025
86MP0005395_other_phenotype0.73104185
87MP0001529_abnormal_vocalization0.71194228
88MP0010030_abnormal_orbit_morphology0.70067306
89MP0000579_abnormal_nail_morphology0.69599087
90MP0003938_abnormal_ear_development0.69403693
91MP0003119_abnormal_digestive_system0.67816714
92MP0002796_impaired_skin_barrier0.67788938
93MP0001119_abnormal_female_reproductive0.67612174
94MP0002638_abnormal_pupillary_reflex0.67280964
95MP0002177_abnormal_outer_ear0.67122986
96MP0005248_abnormal_Harderian_gland0.64688081
97MP0010307_abnormal_tumor_latency0.64011166
98MP0010234_abnormal_vibrissa_follicle0.63656978
99MP0000432_abnormal_head_morphology0.62962046
100MP0003755_abnormal_palate_morphology0.62434316

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.01551868
2Absent/shortened dynein arms (HP:0200106)4.01551868
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.35634775
4Colon cancer (HP:0003003)3.23014661
5Birth length less than 3rd percentile (HP:0003561)3.19532930
6Increased hepatocellular lipid droplets (HP:0006565)3.18601377
7Supernumerary spleens (HP:0009799)3.17712359
8Abnormality of alanine metabolism (HP:0010916)3.11177528
9Hyperalaninemia (HP:0003348)3.11177528
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.11177528
11Tubulointerstitial nephritis (HP:0001970)3.06793704
12Pancreatic fibrosis (HP:0100732)3.05607367
13Lipid accumulation in hepatocytes (HP:0006561)3.03237200
14True hermaphroditism (HP:0010459)3.00174584
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.87794278
16Acute necrotizing encephalopathy (HP:0006965)2.85630820
17Chronic bronchitis (HP:0004469)2.79728545
18Delayed CNS myelination (HP:0002188)2.76230392
19Chromsome breakage (HP:0040012)2.72557466
20Pancreatic cysts (HP:0001737)2.70751628
21Mitochondrial inheritance (HP:0001427)2.63600584
22Acute encephalopathy (HP:0006846)2.59876003
23Volvulus (HP:0002580)2.54798985
24Increased CSF lactate (HP:0002490)2.54644475
25Abnormal ciliary motility (HP:0012262)2.54258606
26Increased serum lactate (HP:0002151)2.53357054
27Abnormality of chromosome stability (HP:0003220)2.50248952
28Abnormal respiratory motile cilium morphology (HP:0005938)2.48034475
29Abnormal respiratory epithelium morphology (HP:0012253)2.48034475
30Abnormal mitochondria in muscle tissue (HP:0008316)2.46124386
31Congenital, generalized hypertrichosis (HP:0004540)2.43338677
32Chronic hepatic failure (HP:0100626)2.42529871
33Abnormal respiratory motile cilium physiology (HP:0012261)2.42505892
34Progressive muscle weakness (HP:0003323)2.41278871
35Increased intramyocellular lipid droplets (HP:0012240)2.41158497
36Premature ovarian failure (HP:0008209)2.40946685
37Ependymoma (HP:0002888)2.40516225
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37275849
39Renal Fanconi syndrome (HP:0001994)2.35362151
40Abnormality of the labia minora (HP:0012880)2.33573078
41Median cleft lip (HP:0000161)2.32463761
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31120617
43Multiple enchondromatosis (HP:0005701)2.29678305
44Pendular nystagmus (HP:0012043)2.27460464
45Progressive macrocephaly (HP:0004481)2.24208911
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22933656
47Hypoplasia of the uterus (HP:0000013)2.22462218
48Abnormal biliary tract physiology (HP:0012439)2.21880305
49Bile duct proliferation (HP:0001408)2.21880305
50Abnormal rod and cone electroretinograms (HP:0008323)2.20389231
51Abnormality of serum amino acid levels (HP:0003112)2.19495772
52Amniotic constriction ring (HP:0009775)2.19293557
53Abnormality of placental membranes (HP:0011409)2.19293557
54Hepatocellular necrosis (HP:0001404)2.18461144
55Sensory axonal neuropathy (HP:0003390)2.14346752
56Nephronophthisis (HP:0000090)2.12421017
57Reduced antithrombin III activity (HP:0001976)2.11090236
58Glioma (HP:0009733)2.09978216
59Abnormality of midbrain morphology (HP:0002418)2.08704428
60Molar tooth sign on MRI (HP:0002419)2.08704428
61Oral leukoplakia (HP:0002745)2.06663846
62Constricted visual fields (HP:0001133)2.06012744
63Septo-optic dysplasia (HP:0100842)2.05350561
64Exertional dyspnea (HP:0002875)2.05261993
65Leukodystrophy (HP:0002415)2.04266858
66Poor eye contact (HP:0000817)1.99910702
67Respiratory difficulties (HP:0002880)1.99395260
68Cystic liver disease (HP:0006706)1.99166326
69Hyperglycinemia (HP:0002154)1.98000016
70Hypergonadotropic hypogonadism (HP:0000815)1.96549944
71Cellular immunodeficiency (HP:0005374)1.94849390
72Aplasia/hypoplasia of the uterus (HP:0008684)1.93859196
73Increased muscle lipid content (HP:0009058)1.92717504
74Lactic acidosis (HP:0003128)1.92441281
75Cerebral edema (HP:0002181)1.91724043
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91660313
77Rhinitis (HP:0012384)1.90740310
78Hepatic necrosis (HP:0002605)1.89858396
79Type I transferrin isoform profile (HP:0003642)1.87478764
80Anencephaly (HP:0002323)1.84336999
81Adrenal hypoplasia (HP:0000835)1.83584240
82Sparse eyelashes (HP:0000653)1.83417773
83Esophageal atresia (HP:0002032)1.82954489
84Sclerocornea (HP:0000647)1.82944350
85Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.82029300
86Meckel diverticulum (HP:0002245)1.81911115
87Acute lymphatic leukemia (HP:0006721)1.81099019
88Abnormal social behavior (HP:0012433)1.79771500
89Impaired social interactions (HP:0000735)1.79771500
90Abnormal lung lobation (HP:0002101)1.76757107
91Squamous cell carcinoma (HP:0002860)1.76228171
92Small hand (HP:0200055)1.75674827
93Neoplasm of the adrenal cortex (HP:0100641)1.75416610
94Asplenia (HP:0001746)1.75396118
95Absent septum pellucidum (HP:0001331)1.72826367
96Pancreatic islet-cell hyperplasia (HP:0004510)1.71681296
97Aplasia/Hypoplasia of the spleen (HP:0010451)1.71403454
98Abnormality of the ileum (HP:0001549)1.68832895
99Hyperglycinuria (HP:0003108)1.68560990
100Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67170637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.78698409
2MST44.43935211
3CDC73.55881278
4VRK23.26854937
5ZAK3.09269568
6MAP4K22.94064050
7MKNK12.94053245
8PLK22.71010998
9SRPK12.57024793
10PBK2.53097612
11SCYL22.44799641
12TTK2.25969981
13TAF12.21816563
14PLK32.11051773
15TNIK2.09147737
16MKNK22.06352380
17WNK42.05611541
18VRK12.03983177
19PLK41.96638142
20BRD41.93260980
21NEK11.90765968
22RPS6KA41.65531703
23BUB11.63288559
24STK161.57074122
25DYRK31.55071814
26EIF2AK11.37329778
27ATR1.36820233
28CDK121.36042291
29TLK11.33187822
30PLK11.32642552
31ALK1.30036848
32OXSR11.23468847
33BMPR1B1.22929669
34TSSK61.19045502
35AURKB1.11935073
36PRKCI1.10478180
37ACVR1B1.07570866
38WEE11.04268098
39CHEK20.99553764
40NME10.90358884
41CHEK10.87126266
42EIF2AK30.86920841
43ATM0.86855270
44CDK30.84496022
45CDK70.84422837
46NUAK10.82696836
47NEK20.81838993
48STK390.81582289
49FLT30.79776543
50PNCK0.78041978
51CSNK1G10.76968152
52CSNK1E0.75730702
53MAP3K40.72952743
54RPS6KB20.69928541
55BCR0.68670952
56CSNK1G30.66343022
57RPS6KA50.65686099
58CSNK2A20.64853197
59GRK10.63651693
60AURKA0.62071257
61CSNK1G20.59934405
62TGFBR10.59472755
63FRK0.58037389
64STK40.53761002
65AKT20.52706263
66CSNK2A10.52485714
67MAP2K70.51033049
68DAPK10.50742180
69CDK20.50583203
70TRIM280.49420636
71CSNK1A1L0.47613734
72STK30.47524769
73ADRBK20.46099846
74DYRK20.45578551
75MUSK0.44309887
76STK38L0.42487976
77CDK10.41024546
78CSNK1A10.40382293
79PRKDC0.37019102
80CCNB10.36976964
81MAP3K80.35941853
82PASK0.33068620
83ERBB40.32952558
84NME20.32120196
85CLK10.31888921
86INSRR0.29855527
87STK100.29618946
88PIK3CG0.29581277
89FGFR10.28370499
90PRKACB0.27422308
91PRKCE0.25952920
92PIM10.25442538
93CDK60.23168412
94MAPK130.22705248
95EIF2AK20.20095942
96WNK30.19218759
97CSNK1D0.18773618
98PRKD30.17381965
99GSK3B0.17141206
100TIE10.16923797

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.15476402
2Mismatch repair_Homo sapiens_hsa034303.69897889
3Non-homologous end-joining_Homo sapiens_hsa034503.69452892
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55014219
5Spliceosome_Homo sapiens_hsa030403.47397216
6Proteasome_Homo sapiens_hsa030503.39212611
7RNA polymerase_Homo sapiens_hsa030203.07809844
8Base excision repair_Homo sapiens_hsa034102.95226207
9One carbon pool by folate_Homo sapiens_hsa006702.56676879
10Homologous recombination_Homo sapiens_hsa034402.49576752
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48925749
12RNA transport_Homo sapiens_hsa030132.45563009
13Basal transcription factors_Homo sapiens_hsa030222.21716421
14Nucleotide excision repair_Homo sapiens_hsa034202.21070528
15Ribosome_Homo sapiens_hsa030102.18304285
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.12499519
17RNA degradation_Homo sapiens_hsa030182.08286224
18Oxidative phosphorylation_Homo sapiens_hsa001902.07278492
19Cell cycle_Homo sapiens_hsa041102.02561892
20Protein export_Homo sapiens_hsa030602.00483395
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.88343644
22Selenocompound metabolism_Homo sapiens_hsa004501.88032153
23Pyrimidine metabolism_Homo sapiens_hsa002401.84374694
24Parkinsons disease_Homo sapiens_hsa050121.78312918
25Huntingtons disease_Homo sapiens_hsa050161.78277527
26Fanconi anemia pathway_Homo sapiens_hsa034601.67038237
27mRNA surveillance pathway_Homo sapiens_hsa030151.65145116
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56986710
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45658064
30Systemic lupus erythematosus_Homo sapiens_hsa053221.44046850
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41033563
32Propanoate metabolism_Homo sapiens_hsa006401.33952318
33Purine metabolism_Homo sapiens_hsa002301.31453487
34Steroid biosynthesis_Homo sapiens_hsa001001.30512076
35Pyruvate metabolism_Homo sapiens_hsa006201.25298199
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15335442
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10949019
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04884388
39Vitamin B6 metabolism_Homo sapiens_hsa007501.01046724
40Glutathione metabolism_Homo sapiens_hsa004800.92943931
41Alzheimers disease_Homo sapiens_hsa050100.88878589
42Phototransduction_Homo sapiens_hsa047440.87265785
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86668876
44p53 signaling pathway_Homo sapiens_hsa041150.83480908
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80532302
46Biosynthesis of amino acids_Homo sapiens_hsa012300.77396173
47Alcoholism_Homo sapiens_hsa050340.72753130
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71371713
49Oocyte meiosis_Homo sapiens_hsa041140.71127213
50Peroxisome_Homo sapiens_hsa041460.68363911
51beta-Alanine metabolism_Homo sapiens_hsa004100.63690480
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61169808
53Carbon metabolism_Homo sapiens_hsa012000.59678164
54Metabolic pathways_Homo sapiens_hsa011000.56359279
55Epstein-Barr virus infection_Homo sapiens_hsa051690.51365629
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50626303
57Asthma_Homo sapiens_hsa053100.46110482
58Tryptophan metabolism_Homo sapiens_hsa003800.43932639
59Arginine and proline metabolism_Homo sapiens_hsa003300.43836491
60Cardiac muscle contraction_Homo sapiens_hsa042600.43287561
61TGF-beta signaling pathway_Homo sapiens_hsa043500.41674963
62Olfactory transduction_Homo sapiens_hsa047400.40306413
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37876662
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37330515
65Viral carcinogenesis_Homo sapiens_hsa052030.35205400
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34507144
67Butanoate metabolism_Homo sapiens_hsa006500.34298964
68Fatty acid elongation_Homo sapiens_hsa000620.34160573
69Herpes simplex infection_Homo sapiens_hsa051680.32920906
70Tight junction_Homo sapiens_hsa045300.32500281
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32234010
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31152182
73Pentose phosphate pathway_Homo sapiens_hsa000300.30474030
74Thyroid cancer_Homo sapiens_hsa052160.30248074
75Fatty acid degradation_Homo sapiens_hsa000710.29507772
76Collecting duct acid secretion_Homo sapiens_hsa049660.28643697
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26666464
78Nitrogen metabolism_Homo sapiens_hsa009100.25562145
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24244331
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.24075151
81Fatty acid metabolism_Homo sapiens_hsa012120.24053496
82Hippo signaling pathway_Homo sapiens_hsa043900.22422188
83Primary immunodeficiency_Homo sapiens_hsa053400.21532677
84Wnt signaling pathway_Homo sapiens_hsa043100.20617790
85Vitamin digestion and absorption_Homo sapiens_hsa049770.20458340
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19753281
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18467543
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17222923
89Arachidonic acid metabolism_Homo sapiens_hsa005900.13721573
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12239024
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11379038
92Basal cell carcinoma_Homo sapiens_hsa052170.09693692
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09451903
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.07884249
95Regulation of autophagy_Homo sapiens_hsa041400.07432035
96Retinol metabolism_Homo sapiens_hsa008300.07401915
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.07386088
98Folate biosynthesis_Homo sapiens_hsa007900.06682307
99Chemical carcinogenesis_Homo sapiens_hsa052040.06626820
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.05919130

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