SETP17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to ethanol (GO:0048149)9.10857167
2negative regulation of cytosolic calcium ion concentration (GO:0051481)8.61429546
3ether lipid metabolic process (GO:0046485)7.31965634
4regulation of protein glycosylation (GO:0060049)6.72163314
5negative regulation of calcium ion-dependent exocytosis (GO:0045955)6.61837031
6negative regulation of nitric oxide biosynthetic process (GO:0045019)6.23531511
7negative regulation of cAMP-mediated signaling (GO:0043951)6.12035823
8sphingosine metabolic process (GO:0006670)5.90734039
9opioid receptor signaling pathway (GO:0038003)5.62633061
10regulation of translational termination (GO:0006449)5.37565964
11diol metabolic process (GO:0034311)5.26218519
12mRNA cleavage (GO:0006379)5.16313934
13glycerol ether metabolic process (GO:0006662)5.09037841
14sphingoid metabolic process (GO:0046519)4.94379708
15regulation of acrosome reaction (GO:0060046)4.87194147
16adult feeding behavior (GO:0008343)4.75821623
17positive regulation of natural killer cell differentiation (GO:0032825)4.67396007
18ether metabolic process (GO:0018904)4.64523304
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.52603682
20brain morphogenesis (GO:0048854)4.52546095
21ovulation cycle (GO:0042698)4.39393554
22aggressive behavior (GO:0002118)4.38289350
23cellular response to interferon-alpha (GO:0035457)4.35232990
24positive regulation of cAMP-mediated signaling (GO:0043950)4.32153578
25piRNA metabolic process (GO:0034587)4.14878315
26negative regulation of glycoprotein biosynthetic process (GO:0010561)4.12621909
27pyrimidine dimer repair (GO:0006290)4.12369143
28vagina development (GO:0060068)3.86102187
29thrombin receptor signaling pathway (GO:0070493)3.86027942
30regulation of extracellular matrix disassembly (GO:0010715)3.85516458
31positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.79053569
32smooth muscle tissue development (GO:0048745)3.77216383
33N-terminal protein amino acid acetylation (GO:0006474)3.72089711
34regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.70403267
35cellular response to ammonium ion (GO:0071242)3.67268763
36positive regulation of natural killer cell activation (GO:0032816)3.60321840
37mitotic cell cycle arrest (GO:0071850)3.57643277
38endothelium development (GO:0003158)3.55236470
39fibroblast migration (GO:0010761)3.50682162
40photoreceptor cell maintenance (GO:0045494)3.43752921
41adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.43516396
42DNA replication-dependent nucleosome organization (GO:0034723)3.43058685
43DNA replication-dependent nucleosome assembly (GO:0006335)3.43058685
44negative regulation of glycoprotein metabolic process (GO:1903019)3.41740412
45hepatocyte apoptotic process (GO:0097284)3.38139105
46regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.35676950
47detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35309879
48response to pheromone (GO:0019236)3.35298028
49relaxation of smooth muscle (GO:0044557)3.30995180
50positive regulation of protein autophosphorylation (GO:0031954)3.30499806
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30286623
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.18417608
53NADH dehydrogenase complex assembly (GO:0010257)3.18417608
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18417608
55negative regulation of neurotransmitter secretion (GO:0046929)3.15655230
56negative regulation of keratinocyte proliferation (GO:0010839)3.13713847
57negative regulation of cell aging (GO:0090344)3.13572874
58water-soluble vitamin biosynthetic process (GO:0042364)3.13056492
59forebrain morphogenesis (GO:0048853)3.10739656
60muscle organ morphogenesis (GO:0048644)3.09069814
61coenzyme catabolic process (GO:0009109)3.08587997
62regulation of Rac protein signal transduction (GO:0035020)3.07263815
63cellular response to alkaloid (GO:0071312)3.04382420
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.99057145
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97501811
66protein complex biogenesis (GO:0070271)2.96524460
67mitochondrial respiratory chain complex assembly (GO:0033108)2.93625984
68regulation of natural killer cell differentiation (GO:0032823)2.93353629
69negative regulation of exocytosis (GO:0045920)2.91465065
70nitric oxide mediated signal transduction (GO:0007263)2.90616352
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87885956
72regulation of helicase activity (GO:0051095)2.87831991
73regulation of glutamate receptor signaling pathway (GO:1900449)2.86160836
74branched-chain amino acid catabolic process (GO:0009083)2.85107771
75proteasome assembly (GO:0043248)2.80405273
76regulation of hypersensitivity (GO:0002883)2.76147173
77preassembly of GPI anchor in ER membrane (GO:0016254)2.75570309
78microtubule severing (GO:0051013)2.73166289
79female genitalia development (GO:0030540)2.68625586
80succinate metabolic process (GO:0006105)2.62265203
81respiratory chain complex IV assembly (GO:0008535)2.62034178
82quinone biosynthetic process (GO:1901663)2.61971959
83ncRNA catabolic process (GO:0034661)2.61187643
84single strand break repair (GO:0000012)2.59808078
85branched-chain amino acid metabolic process (GO:0009081)2.59234573
86regulation of glycoprotein biosynthetic process (GO:0010559)2.59078425
87regulation of execution phase of apoptosis (GO:1900117)2.58097045
88negative regulation of cell-matrix adhesion (GO:0001953)2.53515820
89negative regulation of fatty acid biosynthetic process (GO:0045717)2.53225723
90tachykinin receptor signaling pathway (GO:0007217)2.51196662
91platelet dense granule organization (GO:0060155)2.50982710
92positive regulation of glycoprotein biosynthetic process (GO:0010560)2.49721250
93ribonucleoprotein complex disassembly (GO:0032988)2.49700577
94neuron remodeling (GO:0016322)2.47035718
95tRNA modification (GO:0006400)2.46918016
96positive regulation of cholesterol transport (GO:0032376)2.45622406
97positive regulation of sterol transport (GO:0032373)2.45622406
98regulation of natural killer cell activation (GO:0032814)2.45436726
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45221846
100cytochrome complex assembly (GO:0017004)2.44442408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.13625617
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.62852535
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.85225183
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77300931
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01418586
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.60884069
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.58631503
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.53688115
9VDR_22108803_ChIP-Seq_LS180_Human2.52952550
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.52309612
11ZNF274_21170338_ChIP-Seq_K562_Hela2.40246474
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.22918787
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21749109
14TAF15_26573619_Chip-Seq_HEK293_Human1.96256642
15SOX2_19829295_ChIP-Seq_ESCs_Human1.92823114
16NANOG_19829295_ChIP-Seq_ESCs_Human1.92823114
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92814770
18EZH2_27294783_Chip-Seq_NPCs_Mouse1.87005159
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.82640293
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81801974
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.81718572
22CBP_20019798_ChIP-Seq_JUKART_Human1.78572389
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.78572389
24HTT_18923047_ChIP-ChIP_STHdh_Human1.75278375
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73731521
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72218311
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68500198
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66153976
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62370684
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62037391
31VDR_23849224_ChIP-Seq_CD4+_Human1.59000513
32EWS_26573619_Chip-Seq_HEK293_Human1.56790281
33CRX_20693478_ChIP-Seq_RETINA_Mouse1.56248622
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54839696
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.53019769
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52131843
37CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49438238
38ELK1_19687146_ChIP-ChIP_HELA_Human1.48624032
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44839336
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.43938738
41TFEB_21752829_ChIP-Seq_HELA_Human1.43751130
42FUS_26573619_Chip-Seq_HEK293_Human1.43441432
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37465045
44TP53_22573176_ChIP-Seq_HFKS_Human1.36331258
45SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.33828497
46OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33598110
47BRD4_25478319_ChIP-Seq_HGPS_Human1.33023024
48NANOG_20526341_ChIP-Seq_ESCs_Human1.30971426
49FLI1_21867929_ChIP-Seq_TH2_Mouse1.28080462
50P300_19829295_ChIP-Seq_ESCs_Human1.22178231
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19766875
52DCP1A_22483619_ChIP-Seq_HELA_Human1.19004086
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18467032
54FOXP3_21729870_ChIP-Seq_TREG_Human1.15696149
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15635851
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15632437
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15032731
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13211747
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.12075224
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10107747
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09873204
62E2F7_22180533_ChIP-Seq_HELA_Human1.08360830
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07959266
64TCF4_23295773_ChIP-Seq_U87_Human1.06415919
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06288608
66P300_18555785_Chip-Seq_ESCs_Mouse1.04828971
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.03828878
68GBX2_23144817_ChIP-Seq_PC3_Human1.01470193
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99433729
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99353164
71EGR1_19032775_ChIP-ChIP_M12_Human0.98460098
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97352981
73IRF8_21731497_ChIP-ChIP_J774_Mouse0.97264370
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97096111
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97096111
76SCL_19346495_ChIP-Seq_HPC-7_Human0.97010805
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96473532
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.95256390
79CDX2_22108803_ChIP-Seq_LS180_Human0.94500303
80SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92971599
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.92897802
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92734618
83STAT3_23295773_ChIP-Seq_U87_Human0.92424564
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91880674
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91572338
86CTCF_18555785_Chip-Seq_ESCs_Mouse0.91193782
87SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90141788
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90138289
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89990816
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89833072
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89306355
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87853769
93GATA4_25053715_ChIP-Seq_YYC3_Human0.87540550
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87292330
95TP53_18474530_ChIP-ChIP_U2OS_Human0.86406264
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85734148
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85323752
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.84817759
99NFYB_21822215_ChIP-Seq_K562_Human0.84302183
100NMYC_18555785_Chip-Seq_ESCs_Mouse0.84234136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage4.58632357
2MP0005360_urolithiasis4.16092861
3MP0009780_abnormal_chondrocyte_physiolo3.96330483
4MP0000015_abnormal_ear_pigmentation3.75903443
5MP0009278_abnormal_bone_marrow3.75555897
6MP0000569_abnormal_digit_pigmentation3.23721802
7MP0002876_abnormal_thyroid_physiology3.03099773
8MP0003195_calcinosis2.75188842
9MP0006035_abnormal_mitochondrial_morpho2.59218488
10MP0010234_abnormal_vibrissa_follicle2.58735455
11MP0005084_abnormal_gallbladder_morpholo2.56983577
12MP0002254_reproductive_system_inflammat2.56165145
13MP0005397_hematopoietic_system_phenotyp2.37270722
14MP0001545_abnormal_hematopoietic_system2.37270722
15MP0003191_abnormal_cellular_cholesterol2.29196298
16MP0005646_abnormal_pituitary_gland2.19090812
17MP0001968_abnormal_touch/_nociception2.16527300
18MP0005310_abnormal_salivary_gland1.97888727
19MP0005645_abnormal_hypothalamus_physiol1.94495398
20MP0001501_abnormal_sleep_pattern1.87346778
21MP0009764_decreased_sensitivity_to1.85573807
22MP0008775_abnormal_heart_ventricle1.85477543
23MP0009333_abnormal_splenocyte_physiolog1.84699850
24MP0005503_abnormal_tendon_morphology1.75814183
25MP0003950_abnormal_plasma_membrane1.67808043
26MP0005551_abnormal_eye_electrophysiolog1.64445298
27MP0005332_abnormal_amino_acid1.58368203
28MP0005174_abnormal_tail_pigmentation1.58002300
29MP0003136_yellow_coat_color1.57259464
30MP0008004_abnormal_stomach_pH1.56772843
31MP0003806_abnormal_nucleotide_metabolis1.54827254
32MP0003633_abnormal_nervous_system1.53648537
33MP0003045_fibrosis1.52160137
34MP0010352_gastrointestinal_tract_polyps1.50623696
35MP0001664_abnormal_digestion1.45704280
36MP0003183_abnormal_peptide_metabolism1.43748641
37MP0002733_abnormal_thermal_nociception1.43550832
38MP0001756_abnormal_urination1.36742640
39MP0000372_irregular_coat_pigmentation1.36720184
40MP0008058_abnormal_DNA_repair1.35128759
41MP0000681_abnormal_thyroid_gland1.33848903
42MP0008057_abnormal_DNA_replication1.33544866
43MP0002168_other_aberrant_phenotype1.32737013
44MP0000003_abnormal_adipose_tissue1.30252945
45MP0004134_abnormal_chest_morphology1.23985736
46MP0006036_abnormal_mitochondrial_physio1.22656985
47MP0001970_abnormal_pain_threshold1.19600234
48MP0000358_abnormal_cell_content/1.19551900
49MP0001661_extended_life_span1.18811967
50MP0001485_abnormal_pinna_reflex1.14086884
51MP0003941_abnormal_skin_development1.13047992
52MP0002090_abnormal_vision1.11808471
53MP0003724_increased_susceptibility_to1.11188403
54MP0005464_abnormal_platelet_physiology1.08164277
55MP0006072_abnormal_retinal_apoptosis1.07207178
56MP0002148_abnormal_hypersensitivity_rea1.07096831
57MP0002837_dystrophic_cardiac_calcinosis1.03148047
58MP0002006_tumorigenesis1.00846238
59MP0008877_abnormal_DNA_methylation0.97917053
60MP0003075_altered_response_to0.97740623
61MP0010307_abnormal_tumor_latency0.95485800
62MP0003959_abnormal_lean_body0.94337539
63MP0001851_eye_inflammation0.91440710
64MP0000685_abnormal_immune_system0.90975232
65MP0009046_muscle_twitch0.90448892
66MP0002009_preneoplasia0.90191630
67MP0003646_muscle_fatigue0.89143838
68MP0002971_abnormal_brown_adipose0.87091464
69MP0002095_abnormal_skin_pigmentation0.85120316
70MP0002166_altered_tumor_susceptibility0.84642519
71MP0005623_abnormal_meninges_morphology0.83987727
72MP0005220_abnormal_exocrine_pancreas0.82871398
73MP0003638_abnormal_response/metabolism_0.80619901
74MP0003329_amyloid_beta_deposits0.78366288
75MP0003631_nervous_system_phenotype0.77810997
76MP0000749_muscle_degeneration0.77761662
77MP0001486_abnormal_startle_reflex0.77646082
78MP0005367_renal/urinary_system_phenotyp0.76390571
79MP0000516_abnormal_urinary_system0.76390571
80MP0001835_abnormal_antigen_presentation0.74947059
81MP0002796_impaired_skin_barrier0.74391591
82MP0009745_abnormal_behavioral_response0.68741761
83MP0010329_abnormal_lipoprotein_level0.68558075
84MP0005165_increased_susceptibility_to0.68047445
85MP0006082_CNS_inflammation0.67331587
86MP0001764_abnormal_homeostasis0.67149532
87MP0000604_amyloidosis0.66371349
88MP0000230_abnormal_systemic_arterial0.65279051
89MP0005389_reproductive_system_phenotype0.63118975
90MP0009765_abnormal_xenobiotic_induced0.62849482
91MP0004484_altered_response_of0.62245896
92MP0002163_abnormal_gland_morphology0.61960981
93MP0000465_gastrointestinal_hemorrhage0.61498582
94MP0001879_abnormal_lymphatic_vessel0.61371799
95MP0002102_abnormal_ear_morphology0.61368591
96MP0002693_abnormal_pancreas_physiology0.61155144
97MP0004147_increased_porphyrin_level0.59289436
98MP0009643_abnormal_urine_homeostasis0.58081098
99MP0001984_abnormal_olfaction0.57171452
100MP0000427_abnormal_hair_cycle0.55757044

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)8.08892832
2Sensory axonal neuropathy (HP:0003390)5.99533559
3Volvulus (HP:0002580)5.60117293
4Facial diplegia (HP:0001349)4.43568073
5Progressive inability to walk (HP:0002505)4.21488310
6Large for gestational age (HP:0001520)3.98079548
7Hyperthyroidism (HP:0000836)3.91454294
8Intestinal atresia (HP:0011100)3.78553092
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.64024512
10Pancreatic islet-cell hyperplasia (HP:0004510)3.59781024
11Poor head control (HP:0002421)3.57057781
12Increased hepatocellular lipid droplets (HP:0006565)3.04695146
13Hypoproteinemia (HP:0003075)2.85975385
14Neuroendocrine neoplasm (HP:0100634)2.80058645
15Myositis (HP:0100614)2.70513796
16Poor speech (HP:0002465)2.64939421
17Pheochromocytoma (HP:0002666)2.64510887
18Constricted visual fields (HP:0001133)2.63901144
19Chromsome breakage (HP:0040012)2.60707892
20Congenital ichthyosiform erythroderma (HP:0007431)2.60290618
21Broad alveolar ridges (HP:0000187)2.60196810
22Thickened helices (HP:0000391)2.59603041
23Abnormal rod and cone electroretinograms (HP:0008323)2.59246283
24Attenuation of retinal blood vessels (HP:0007843)2.55547413
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.55056199
26Lipid accumulation in hepatocytes (HP:0006561)2.53449248
27Cerebral hypomyelination (HP:0006808)2.52940298
28Focal motor seizures (HP:0011153)2.46708631
29Respiratory difficulties (HP:0002880)2.46405447
30Inability to walk (HP:0002540)2.45418898
31Orchitis (HP:0100796)2.43929120
32Hemiparesis (HP:0001269)2.39496731
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35201039
34Albinism (HP:0001022)2.33031431
35Large eyes (HP:0001090)2.32227736
36Microretrognathia (HP:0000308)2.32225874
37Severe visual impairment (HP:0001141)2.31920489
38Pigmentary retinal degeneration (HP:0001146)2.22919481
39Hepatocellular necrosis (HP:0001404)2.21544166
40Recurrent skin infections (HP:0001581)2.19777255
41Autoimmune hemolytic anemia (HP:0001890)2.19061438
42Increased CSF lactate (HP:0002490)2.18470161
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15487718
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15487718
45Abnormality of the ileum (HP:0001549)2.12755762
46Hepatic necrosis (HP:0002605)2.12064601
47Choroideremia (HP:0001139)2.10963065
48Pancreatic cysts (HP:0001737)2.10755026
49Abnormality of the aortic arch (HP:0012303)2.09985207
50Optic neuritis (HP:0100653)2.08992256
51Retrobulbar optic neuritis (HP:0100654)2.08992256
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07988963
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07882195
54Intention tremor (HP:0002080)2.05458829
55Increased intramyocellular lipid droplets (HP:0012240)2.04352672
56Retinal atrophy (HP:0001105)2.03713956
57Mitochondrial inheritance (HP:0001427)2.02244663
58Difficulty running (HP:0009046)1.99579213
59Tented upper lip vermilion (HP:0010804)1.99286966
60Methylmalonic acidemia (HP:0002912)1.98891978
61Progressive macrocephaly (HP:0004481)1.98176184
62Medial flaring of the eyebrow (HP:0010747)1.94214056
63Abnormality of urine glucose concentration (HP:0011016)1.91238710
64Glycosuria (HP:0003076)1.91238710
65Absent speech (HP:0001344)1.91188962
66Acute necrotizing encephalopathy (HP:0006965)1.90341643
67Hamartoma of the eye (HP:0010568)1.88668462
68Abnormality of chromosome stability (HP:0003220)1.88599307
69Pancreatic fibrosis (HP:0100732)1.87989651
70Abnormality of transition element cation homeostasis (HP:0011030)1.86201663
71Facial shape deformation (HP:0011334)1.83150456
72Potter facies (HP:0002009)1.83150456
73Chorioretinal atrophy (HP:0000533)1.81402727
74Delayed gross motor development (HP:0002194)1.79511888
75Ragged-red muscle fibers (HP:0003200)1.79466198
76Renal cortical cysts (HP:0000803)1.79361337
77Methylmalonic aciduria (HP:0012120)1.78651885
78Abnormality of vitamin B metabolism (HP:0004340)1.78379075
79Aqueductal stenosis (HP:0002410)1.77840014
80Hypertensive crisis (HP:0100735)1.72985894
81Hydroxyprolinuria (HP:0003080)1.72685540
82Abnormality of proline metabolism (HP:0010907)1.72685540
83Abnormality of iron homeostasis (HP:0011031)1.72502984
84Prolonged bleeding time (HP:0003010)1.71668190
85Osteolytic defects of the hand bones (HP:0009699)1.71543610
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.71543610
87Spastic paraparesis (HP:0002313)1.70667800
88Hyperpituitarism (HP:0010514)1.69995374
89Episodic fever (HP:0001954)1.69609692
90Abnormality of macular pigmentation (HP:0008002)1.69505329
91Increased serum lactate (HP:0002151)1.69390280
92Renal Fanconi syndrome (HP:0001994)1.67261524
93Gaze-evoked nystagmus (HP:0000640)1.67035741
94Parakeratosis (HP:0001036)1.66849244
95Tubular atrophy (HP:0000092)1.66702759
96Amelogenesis imperfecta (HP:0000705)1.66645814
97Elevated erythrocyte sedimentation rate (HP:0003565)1.66630081
98Abnormality of endocrine pancreas physiology (HP:0012093)1.64084961
99Abnormality of the pancreatic islet cells (HP:0006476)1.64084961
100Gastrointestinal atresia (HP:0002589)1.63458345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.51799628
2ADRBK25.52953264
3PINK14.06062245
4STK243.63931880
5STK38L3.22833837
6ACVR1B2.52200002
7MST42.35579777
8STK392.14932605
9PAK32.14212603
10GRK11.96956694
11OXSR11.93316737
12EIF2AK31.90607008
13BMPR1B1.86972278
14PBK1.85777609
15LIMK11.78001540
16IRAK31.71719110
17ADRBK11.71288948
18FGFR21.66338147
19ERN11.57310066
20PRKCE1.45525498
21DYRK31.43018102
22MKNK21.38567868
23TGFBR11.30634053
24NEK91.30536448
25STK31.12012671
26STK381.06557981
27DDR21.06416494
28STK160.99479872
29BRD40.97828218
30MKNK10.91598322
31PRKCG0.89967867
32ZAP700.80747429
33TRPM70.78965179
34GRK60.78481095
35TNIK0.76695771
36PRKCI0.74710125
37TEC0.73819253
38CDK90.72971425
39MAP3K30.72722769
40CAMK2D0.72575638
41PLK20.69657753
42MAP2K30.69562736
43CAMK2A0.69498911
44TXK0.68772849
45BCKDK0.68509994
46HCK0.66792442
47SYK0.66727825
48EIF2AK20.66029960
49DAPK20.64398668
50FER0.63648973
51TNK20.61791922
52TESK10.54345483
53PRKD20.54135120
54CHEK20.53974366
55STK100.52084307
56OBSCN0.51717999
57ABL10.50730617
58MAPK110.50561501
59PNCK0.48474809
60PDK20.46673211
61TBK10.46448751
62IKBKB0.45678328
63CSNK1A1L0.45485438
64GSK3A0.45409888
65CLK10.44495717
66CDC70.43318558
67MAPK130.42130674
68GRK70.41971129
69CSNK2A20.41607712
70PAK20.41228922
71NME20.39870619
72MAP2K60.39735920
73ERBB30.39090590
74MAP2K10.38351578
75WNK40.38017921
76TYK20.37371260
77MAPKAPK30.37267985
78PLK30.36563912
79SRPK10.36269187
80PHKG20.36185853
81PHKG10.36185853
82RPS6KB20.36153946
83CSNK1G20.35061244
84LCK0.34541112
85PRKD10.34499474
86AKT20.33932167
87CSNK1A10.33353910
88PRKCQ0.32863186
89PRKACB0.32090783
90AURKB0.31954891
91CSNK1G30.31907342
92PRKCA0.31546201
93CDC42BPA0.30176254
94ATM0.28819345
95ATR0.28816080
96INSR0.24470129
97BMPR20.23986312
98CSNK1G10.23480284
99BTK0.22886699
100MAPK30.22769173

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.94060136
2Non-homologous end-joining_Homo sapiens_hsa034503.62345692
3Vitamin B6 metabolism_Homo sapiens_hsa007503.37588253
4Dorso-ventral axis formation_Homo sapiens_hsa043203.00142374
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.76802017
6Proteasome_Homo sapiens_hsa030502.74605543
7Fatty acid elongation_Homo sapiens_hsa000622.61612557
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45010986
9Propanoate metabolism_Homo sapiens_hsa006402.35547153
10Nitrogen metabolism_Homo sapiens_hsa009102.30021530
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.24712494
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19694050
13RNA polymerase_Homo sapiens_hsa030202.11615892
14Sulfur metabolism_Homo sapiens_hsa009202.00708058
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96652455
16Fatty acid degradation_Homo sapiens_hsa000711.89824685
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75723686
18Phototransduction_Homo sapiens_hsa047441.72842104
19Homologous recombination_Homo sapiens_hsa034401.72478992
20Collecting duct acid secretion_Homo sapiens_hsa049661.71671779
21Mineral absorption_Homo sapiens_hsa049781.70439765
22Sphingolipid metabolism_Homo sapiens_hsa006001.69065829
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68402999
24One carbon pool by folate_Homo sapiens_hsa006701.57855258
25Pyrimidine metabolism_Homo sapiens_hsa002401.47200513
26Olfactory transduction_Homo sapiens_hsa047401.45468134
27RNA degradation_Homo sapiens_hsa030181.41907640
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41511114
29Purine metabolism_Homo sapiens_hsa002301.36597487
30Sulfur relay system_Homo sapiens_hsa041221.31953661
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30728980
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.24374425
33Oxidative phosphorylation_Homo sapiens_hsa001901.20882299
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17034644
35Tryptophan metabolism_Homo sapiens_hsa003801.10985952
36Caffeine metabolism_Homo sapiens_hsa002320.99412171
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.98946825
38Primary bile acid biosynthesis_Homo sapiens_hsa001200.98284210
39Salivary secretion_Homo sapiens_hsa049700.97639448
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96634208
41Legionellosis_Homo sapiens_hsa051340.95885955
42ABC transporters_Homo sapiens_hsa020100.95047521
43Starch and sucrose metabolism_Homo sapiens_hsa005000.93470542
44Arachidonic acid metabolism_Homo sapiens_hsa005900.92099732
45Butanoate metabolism_Homo sapiens_hsa006500.86747920
46Lysosome_Homo sapiens_hsa041420.86654470
47Pancreatic secretion_Homo sapiens_hsa049720.86128619
48Parkinsons disease_Homo sapiens_hsa050120.85510628
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85101855
50Fanconi anemia pathway_Homo sapiens_hsa034600.84938406
51Peroxisome_Homo sapiens_hsa041460.83704582
52Basal transcription factors_Homo sapiens_hsa030220.82610360
53Ovarian steroidogenesis_Homo sapiens_hsa049130.79691352
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79582910
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79157945
56Metabolic pathways_Homo sapiens_hsa011000.77076106
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72011867
58mRNA surveillance pathway_Homo sapiens_hsa030150.69024968
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68851028
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67160320
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66908591
62Glutathione metabolism_Homo sapiens_hsa004800.65763363
63Complement and coagulation cascades_Homo sapiens_hsa046100.62943619
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60968951
65Huntingtons disease_Homo sapiens_hsa050160.59468777
66Chemical carcinogenesis_Homo sapiens_hsa052040.56851150
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.55156007
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.54339161
69Rheumatoid arthritis_Homo sapiens_hsa053230.53274651
70Alzheimers disease_Homo sapiens_hsa050100.52146189
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49929920
72Protein export_Homo sapiens_hsa030600.48796068
73Base excision repair_Homo sapiens_hsa034100.47597114
74Taste transduction_Homo sapiens_hsa047420.45925795
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45097020
76Selenocompound metabolism_Homo sapiens_hsa004500.43526200
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42822190
78Asthma_Homo sapiens_hsa053100.42261387
79Primary immunodeficiency_Homo sapiens_hsa053400.41490732
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40690675
81Renin secretion_Homo sapiens_hsa049240.38426872
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38155853
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37218739
84Fatty acid metabolism_Homo sapiens_hsa012120.35213442
85Glycerolipid metabolism_Homo sapiens_hsa005610.34349096
86MicroRNAs in cancer_Homo sapiens_hsa052060.33102165
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32934818
88Circadian rhythm_Homo sapiens_hsa047100.32881399
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31420063
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29658924
91Folate biosynthesis_Homo sapiens_hsa007900.29037030
92Nucleotide excision repair_Homo sapiens_hsa034200.28597459
93African trypanosomiasis_Homo sapiens_hsa051430.28535177
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28188822
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28092810
96Platelet activation_Homo sapiens_hsa046110.27715531
97Calcium signaling pathway_Homo sapiens_hsa040200.27624835
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27611213
99Vibrio cholerae infection_Homo sapiens_hsa051100.25808370
100Circadian entrainment_Homo sapiens_hsa047130.25215085

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »