

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neuronal action potential propagation (GO:0019227) | 8.66252501 |
| 2 | gamma-aminobutyric acid transport (GO:0015812) | 7.35437736 |
| 3 | detection of light stimulus involved in sensory perception (GO:0050962) | 6.11127929 |
| 4 | detection of light stimulus involved in visual perception (GO:0050908) | 6.11127929 |
| 5 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 5.19697738 |
| 6 | regulation of translation, ncRNA-mediated (GO:0045974) | 5.19697738 |
| 7 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 5.19697738 |
| 8 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 5.01207737 |
| 9 | regulation of voltage-gated calcium channel activity (GO:1901385) | 4.77355706 |
| 10 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 4.75898153 |
| 11 | Peyers patch development (GO:0048541) | 4.34758788 |
| 12 | mucosal-associated lymphoid tissue development (GO:0048537) | 4.34758788 |
| 13 | chemosensory behavior (GO:0007635) | 4.30960258 |
| 14 | regulation of posttranscriptional gene silencing (GO:0060147) | 4.16568425 |
| 15 | regulation of gene silencing by miRNA (GO:0060964) | 4.16568425 |
| 16 | regulation of gene silencing by RNA (GO:0060966) | 4.16568425 |
| 17 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 4.11435616 |
| 18 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.98783735 |
| 19 | histone H4-K8 acetylation (GO:0043982) | 3.97655448 |
| 20 | histone H4-K5 acetylation (GO:0043981) | 3.97655448 |
| 21 | negative regulation of actin filament bundle assembly (GO:0032232) | 3.95023776 |
| 22 | positive regulation of mRNA catabolic process (GO:0061014) | 3.92721071 |
| 23 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.83320388 |
| 24 | regulation of sarcomere organization (GO:0060297) | 3.74377700 |
| 25 | positive regulation of mRNA 3-end processing (GO:0031442) | 3.72340508 |
| 26 | pseudouridine synthesis (GO:0001522) | 3.71936780 |
| 27 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.70712859 |
| 28 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213) | 3.67792391 |
| 29 | regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211) | 3.67792391 |
| 30 | maturation of 5.8S rRNA (GO:0000460) | 3.63302191 |
| 31 | intra-S DNA damage checkpoint (GO:0031573) | 3.59461358 |
| 32 | positive regulation of mRNA metabolic process (GO:1903313) | 3.58920372 |
| 33 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.58559087 |
| 34 | synaptic transmission, glutamatergic (GO:0035249) | 3.58158800 |
| 35 | gonadal mesoderm development (GO:0007506) | 3.55564977 |
| 36 | cellular ketone body metabolic process (GO:0046950) | 3.53463751 |
| 37 | regulation of chromatin binding (GO:0035561) | 3.50776600 |
| 38 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.47118312 |
| 39 | phosphatidylethanolamine acyl-chain remodeling (GO:0036152) | 3.45959939 |
| 40 | response to misfolded protein (GO:0051788) | 3.42909540 |
| 41 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151) | 3.41120742 |
| 42 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO | 3.41120742 |
| 43 | positive regulation of mRNA processing (GO:0050685) | 3.40310450 |
| 44 | reflex (GO:0060004) | 3.39389012 |
| 45 | positive regulation of inositol phosphate biosynthetic process (GO:0060732) | 3.39292474 |
| 46 | regulation of mRNA catabolic process (GO:0061013) | 3.39166165 |
| 47 | positive regulation of DNA-templated transcription, initiation (GO:2000144) | 3.37418711 |
| 48 | righting reflex (GO:0060013) | 3.36724187 |
| 49 | DNA deamination (GO:0045006) | 3.35070069 |
| 50 | nucleoside diphosphate catabolic process (GO:0009134) | 3.34106560 |
| 51 | serotonin metabolic process (GO:0042428) | 3.23560843 |
| 52 | regulation of mRNA 3-end processing (GO:0031440) | 3.18991815 |
| 53 | kynurenine metabolic process (GO:0070189) | 3.16122291 |
| 54 | auditory receptor cell stereocilium organization (GO:0060088) | 3.14371727 |
| 55 | behavioral response to nicotine (GO:0035095) | 3.12127605 |
| 56 | primary amino compound metabolic process (GO:1901160) | 3.11171899 |
| 57 | single strand break repair (GO:0000012) | 3.10325419 |
| 58 | L-methionine salvage (GO:0071267) | 3.10150915 |
| 59 | L-methionine biosynthetic process (GO:0071265) | 3.10150915 |
| 60 | amino acid salvage (GO:0043102) | 3.10150915 |
| 61 | ketone body metabolic process (GO:1902224) | 3.09115690 |
| 62 | keratinocyte development (GO:0003334) | 3.04997179 |
| 63 | sodium-independent organic anion transport (GO:0043252) | 3.02337911 |
| 64 | membrane depolarization during action potential (GO:0086010) | 3.01971162 |
| 65 | regulation of hippo signaling (GO:0035330) | 3.01243539 |
| 66 | glutamate receptor signaling pathway (GO:0007215) | 3.00232633 |
| 67 | photoreceptor cell maintenance (GO:0045494) | 2.98213282 |
| 68 | cAMP catabolic process (GO:0006198) | 2.97828237 |
| 69 | response to acidic pH (GO:0010447) | 2.95239603 |
| 70 | cAMP metabolic process (GO:0046058) | 2.89804040 |
| 71 | protein-chromophore linkage (GO:0018298) | 2.85491724 |
| 72 | histone H4-K16 acetylation (GO:0043984) | 2.85112967 |
| 73 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052 | 2.82729522 |
| 74 | phosphatidylcholine acyl-chain remodeling (GO:0036151) | 2.78846959 |
| 75 | vocalization behavior (GO:0071625) | 2.77674309 |
| 76 | ribosome biogenesis (GO:0042254) | 2.75578020 |
| 77 | regulation of gene silencing (GO:0060968) | 2.74581937 |
| 78 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.74544011 |
| 79 | cellular response to pH (GO:0071467) | 2.70353837 |
| 80 | forebrain neuron differentiation (GO:0021879) | 2.68190481 |
| 81 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.67226201 |
| 82 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.65948683 |
| 83 | protein K48-linked deubiquitination (GO:0071108) | 2.62144850 |
| 84 | cyclic nucleotide catabolic process (GO:0009214) | 2.60493246 |
| 85 | protein localization to synapse (GO:0035418) | 2.59179392 |
| 86 | glycerophospholipid catabolic process (GO:0046475) | 2.58132383 |
| 87 | phosphatidylglycerol acyl-chain remodeling (GO:0036148) | 2.57890131 |
| 88 | behavioral response to ethanol (GO:0048149) | 2.55530768 |
| 89 | histone-serine phosphorylation (GO:0035404) | 2.55324209 |
| 90 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.55032630 |
| 91 | appendage development (GO:0048736) | 2.54949734 |
| 92 | limb development (GO:0060173) | 2.54949734 |
| 93 | positive regulation of CREB transcription factor activity (GO:0032793) | 2.51666050 |
| 94 | spinal cord motor neuron differentiation (GO:0021522) | 2.50712845 |
| 95 | negative regulation of gene silencing (GO:0060969) | 2.48945405 |
| 96 | parturition (GO:0007567) | 2.48081767 |
| 97 | negative regulation by host of viral transcription (GO:0043922) | 2.46239052 |
| 98 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.46045878 |
| 99 | dendritic spine morphogenesis (GO:0060997) | 2.45143016 |
| 100 | NLS-bearing protein import into nucleus (GO:0006607) | 2.44791653 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 7.16831732 |
| 2 | VDR_22108803_ChIP-Seq_LS180_Human | 4.75576573 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.17341828 |
| 4 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.01138206 |
| 5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.63301066 |
| 6 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.58344680 |
| 7 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.37186990 |
| 8 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.31912269 |
| 9 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.24868888 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.23092188 |
| 11 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.20872326 |
| 12 | BCAT_22108803_ChIP-Seq_LS180_Human | 2.17923768 |
| 13 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.11937309 |
| 14 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.98014306 |
| 15 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.91850728 |
| 16 | EWS_26573619_Chip-Seq_HEK293_Human | 1.87344777 |
| 17 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.86699909 |
| 18 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.86468145 |
| 19 | FUS_26573619_Chip-Seq_HEK293_Human | 1.74072751 |
| 20 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.73595436 |
| 21 | STAT3_23295773_ChIP-Seq_U87_Human | 1.70709866 |
| 22 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.69598667 |
| 23 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.69327359 |
| 24 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.68387197 |
| 25 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.66639595 |
| 26 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.65348065 |
| 27 | P300_19829295_ChIP-Seq_ESCs_Human | 1.64144378 |
| 28 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.62365449 |
| 29 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.60373308 |
| 30 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.58415248 |
| 31 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.58108061 |
| 32 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.57707442 |
| 33 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.54076383 |
| 34 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.47505025 |
| 35 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.47223236 |
| 36 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.45874346 |
| 37 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.45784120 |
| 38 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.45765295 |
| 39 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.45765295 |
| 40 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.45463796 |
| 41 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.45139957 |
| 42 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.42042456 |
| 43 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.42042456 |
| 44 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.40790147 |
| 45 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.39964895 |
| 46 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.37946167 |
| 47 | TCF4_23295773_ChIP-Seq_U87_Human | 1.35137351 |
| 48 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.34551465 |
| 49 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.34162859 |
| 50 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.33055819 |
| 51 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.32923797 |
| 52 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.31228496 |
| 53 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.30844541 |
| 54 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.29875032 |
| 55 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.29706550 |
| 56 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.29578539 |
| 57 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.29578539 |
| 58 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.27061431 |
| 59 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.23876442 |
| 60 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.21829824 |
| 61 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.21524406 |
| 62 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.21036373 |
| 63 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.19549988 |
| 64 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.19512003 |
| 65 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.18089279 |
| 66 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.17802607 |
| 67 | AR_25329375_ChIP-Seq_VCAP_Human | 1.17507040 |
| 68 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.17362418 |
| 69 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.15150615 |
| 70 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.14816676 |
| 71 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.14781382 |
| 72 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.14363755 |
| 73 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11918892 |
| 74 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.11462853 |
| 75 | TP53_16413492_ChIP-PET_HCT116_Human | 1.09904710 |
| 76 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.09586835 |
| 77 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.08553974 |
| 78 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.08228988 |
| 79 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.08163362 |
| 80 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.07082205 |
| 81 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.05359080 |
| 82 | JUN_21703547_ChIP-Seq_K562_Human | 1.05027198 |
| 83 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.03577187 |
| 84 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.03235961 |
| 85 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.03087518 |
| 86 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.02000891 |
| 87 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.01465492 |
| 88 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.01116311 |
| 89 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.00220889 |
| 90 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.99602564 |
| 91 | KDM2B_26808549_Chip-Seq_REH_Human | 0.97924714 |
| 92 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.97524610 |
| 93 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.97465930 |
| 94 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.97465930 |
| 95 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.95865062 |
| 96 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.92930818 |
| 97 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.91018217 |
| 98 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.90968549 |
| 99 | AR_20517297_ChIP-Seq_VCAP_Human | 0.90671107 |
| 100 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.90595846 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005377_hearing/vestibular/ear_phenot | 3.28497571 |
| 2 | MP0003878_abnormal_ear_physiology | 3.28497571 |
| 3 | MP0002102_abnormal_ear_morphology | 3.27893127 |
| 4 | MP0005423_abnormal_somatic_nervous | 3.13354618 |
| 5 | MP0006292_abnormal_olfactory_placode | 3.01266346 |
| 6 | MP0001501_abnormal_sleep_pattern | 2.83385121 |
| 7 | MP0009745_abnormal_behavioral_response | 2.67205626 |
| 8 | MP0002653_abnormal_ependyma_morphology | 2.58710092 |
| 9 | MP0002822_catalepsy | 2.55581800 |
| 10 | MP0001188_hyperpigmentation | 2.52325860 |
| 11 | MP0005645_abnormal_hypothalamus_physiol | 2.46909249 |
| 12 | MP0000631_abnormal_neuroendocrine_gland | 2.37091336 |
| 13 | MP0004742_abnormal_vestibular_system | 2.20609969 |
| 14 | MP0008789_abnormal_olfactory_epithelium | 2.14179855 |
| 15 | MP0002272_abnormal_nervous_system | 2.13021304 |
| 16 | MP0008057_abnormal_DNA_replication | 2.07057939 |
| 17 | MP0003195_calcinosis | 2.04983518 |
| 18 | MP0005084_abnormal_gallbladder_morpholo | 1.98648078 |
| 19 | MP0005647_abnormal_sex_gland | 1.98324558 |
| 20 | MP0001485_abnormal_pinna_reflex | 1.97094608 |
| 21 | MP0001968_abnormal_touch/_nociception | 1.93768222 |
| 22 | MP0001486_abnormal_startle_reflex | 1.93013648 |
| 23 | MP0003950_abnormal_plasma_membrane | 1.89172460 |
| 24 | MP0003635_abnormal_synaptic_transmissio | 1.86685968 |
| 25 | MP0008058_abnormal_DNA_repair | 1.85245706 |
| 26 | MP0002138_abnormal_hepatobiliary_system | 1.84293883 |
| 27 | MP0009046_muscle_twitch | 1.82956614 |
| 28 | MP0005551_abnormal_eye_electrophysiolog | 1.73747272 |
| 29 | MP0003693_abnormal_embryo_hatching | 1.73415699 |
| 30 | MP0002736_abnormal_nociception_after | 1.73004936 |
| 31 | MP0002572_abnormal_emotion/affect_behav | 1.71886550 |
| 32 | MP0001440_abnormal_grooming_behavior | 1.68677471 |
| 33 | MP0005394_taste/olfaction_phenotype | 1.67447993 |
| 34 | MP0005499_abnormal_olfactory_system | 1.67447993 |
| 35 | MP0002733_abnormal_thermal_nociception | 1.67048093 |
| 36 | MP0000566_synostosis | 1.64935444 |
| 37 | MP0001905_abnormal_dopamine_level | 1.64699501 |
| 38 | MP0001348_abnormal_lacrimal_gland | 1.53180332 |
| 39 | MP0003866_abnormal_defecation | 1.53128030 |
| 40 | MP0002064_seizures | 1.52177308 |
| 41 | MP0004147_increased_porphyrin_level | 1.51871328 |
| 42 | MP0002557_abnormal_social/conspecific_i | 1.47992367 |
| 43 | MP0002067_abnormal_sensory_capabilities | 1.44142114 |
| 44 | MP0002735_abnormal_chemical_nociception | 1.40561886 |
| 45 | MP0001970_abnormal_pain_threshold | 1.39290663 |
| 46 | MP0003880_abnormal_central_pattern | 1.36151510 |
| 47 | MP0003119_abnormal_digestive_system | 1.34494369 |
| 48 | MP0008877_abnormal_DNA_methylation | 1.33216521 |
| 49 | MP0003567_abnormal_fetal_cardiomyocyte | 1.31804864 |
| 50 | MP0001963_abnormal_hearing_physiology | 1.30495932 |
| 51 | MP0005671_abnormal_response_to | 1.29479506 |
| 52 | MP0002928_abnormal_bile_duct | 1.27722375 |
| 53 | MP0005386_behavior/neurological_phenoty | 1.22002407 |
| 54 | MP0004924_abnormal_behavior | 1.22002407 |
| 55 | MP0003943_abnormal_hepatobiliary_system | 1.20445028 |
| 56 | MP0008875_abnormal_xenobiotic_pharmacok | 1.19100211 |
| 57 | MP0000026_abnormal_inner_ear | 1.18668354 |
| 58 | MP0003011_delayed_dark_adaptation | 1.14718588 |
| 59 | MP0003252_abnormal_bile_duct | 1.12805055 |
| 60 | MP0002752_abnormal_somatic_nervous | 1.12394217 |
| 61 | MP0002938_white_spotting | 1.12278498 |
| 62 | MP0002184_abnormal_innervation | 1.12225156 |
| 63 | MP0004885_abnormal_endolymph | 1.09662676 |
| 64 | MP0003718_maternal_effect | 1.08968301 |
| 65 | MP0005167_abnormal_blood-brain_barrier | 1.06685371 |
| 66 | MP0004142_abnormal_muscle_tone | 1.04259636 |
| 67 | MP0004145_abnormal_muscle_electrophysio | 1.04047135 |
| 68 | MP0002734_abnormal_mechanical_nocicepti | 1.00821898 |
| 69 | MP0008872_abnormal_physiological_respon | 0.98280871 |
| 70 | MP0006276_abnormal_autonomic_nervous | 0.96361048 |
| 71 | MP0002063_abnormal_learning/memory/cond | 0.94266002 |
| 72 | MP0003183_abnormal_peptide_metabolism | 0.94260629 |
| 73 | MP0003698_abnormal_male_reproductive | 0.93734771 |
| 74 | MP0005379_endocrine/exocrine_gland_phen | 0.93506900 |
| 75 | MP0000955_abnormal_spinal_cord | 0.92697936 |
| 76 | MP0010094_abnormal_chromosome_stability | 0.92469987 |
| 77 | MP0001293_anophthalmia | 0.91342945 |
| 78 | MP0002210_abnormal_sex_determination | 0.88437968 |
| 79 | MP0002152_abnormal_brain_morphology | 0.88110171 |
| 80 | MP0000653_abnormal_sex_gland | 0.88060814 |
| 81 | MP0000569_abnormal_digit_pigmentation | 0.83671517 |
| 82 | MP0002909_abnormal_adrenal_gland | 0.81302067 |
| 83 | MP0001929_abnormal_gametogenesis | 0.80153094 |
| 84 | MP0000049_abnormal_middle_ear | 0.79248740 |
| 85 | MP0003115_abnormal_respiratory_system | 0.78524947 |
| 86 | MP0003111_abnormal_nucleus_morphology | 0.78335707 |
| 87 | MP0003136_yellow_coat_color | 0.75285235 |
| 88 | MP0005389_reproductive_system_phenotype | 0.74196890 |
| 89 | MP0002396_abnormal_hematopoietic_system | 0.74174792 |
| 90 | MP0002066_abnormal_motor_capabilities/c | 0.72891150 |
| 91 | MP0001765_abnormal_ion_homeostasis | 0.70870395 |
| 92 | MP0003315_abnormal_perineum_morphology | 0.70060897 |
| 93 | MP0000639_abnormal_adrenal_gland | 0.69788431 |
| 94 | MP0002882_abnormal_neuron_morphology | 0.69697781 |
| 95 | MP0002693_abnormal_pancreas_physiology | 0.68094183 |
| 96 | MP0001145_abnormal_male_reproductive | 0.67615970 |
| 97 | MP0008770_decreased_survivor_rate | 0.66340502 |
| 98 | MP0001119_abnormal_female_reproductive | 0.66148515 |
| 99 | MP0005083_abnormal_biliary_tract | 0.65724744 |
| 100 | MP0002160_abnormal_reproductive_system | 0.64981212 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Bilateral sensorineural hearing impairment (HP:0008619) | 5.11362298 |
| 2 | Facial shape deformation (HP:0011334) | 4.75728883 |
| 3 | Potter facies (HP:0002009) | 4.75728883 |
| 4 | Gaze-evoked nystagmus (HP:0000640) | 4.74508172 |
| 5 | Decreased central vision (HP:0007663) | 4.69460226 |
| 6 | Abnormality of the pons (HP:0007361) | 4.26321892 |
| 7 | Genetic anticipation (HP:0003743) | 4.15728190 |
| 8 | Hyperventilation (HP:0002883) | 4.07817561 |
| 9 | Abnormality of the diencephalon (HP:0010662) | 3.89237146 |
| 10 | Duplicated collecting system (HP:0000081) | 3.65393037 |
| 11 | Progressive cerebellar ataxia (HP:0002073) | 3.55172849 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.50110872 |
| 13 | Absent/shortened dynein arms (HP:0200106) | 3.42485518 |
| 14 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.42485518 |
| 15 | Febrile seizures (HP:0002373) | 3.25357663 |
| 16 | Retinal dysplasia (HP:0007973) | 3.24985472 |
| 17 | Tubulointerstitial fibrosis (HP:0005576) | 3.23675166 |
| 18 | Clumsiness (HP:0002312) | 3.23311568 |
| 19 | Abnormality of the renal collecting system (HP:0004742) | 3.19671164 |
| 20 | Abnormality of alanine metabolism (HP:0010916) | 3.13868991 |
| 21 | Hyperalaninemia (HP:0003348) | 3.13868991 |
| 22 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.13868991 |
| 23 | Fair hair (HP:0002286) | 3.13707191 |
| 24 | Increased corneal curvature (HP:0100692) | 2.90369586 |
| 25 | Keratoconus (HP:0000563) | 2.90369586 |
| 26 | Inability to walk (HP:0002540) | 2.87043602 |
| 27 | Hypoplasia of the pons (HP:0012110) | 2.85990387 |
| 28 | Inappropriate behavior (HP:0000719) | 2.85286508 |
| 29 | Tubular atrophy (HP:0000092) | 2.81632321 |
| 30 | Dysmetric saccades (HP:0000641) | 2.71055211 |
| 31 | Dysautonomia (HP:0002459) | 2.65047633 |
| 32 | Polydipsia (HP:0001959) | 2.62237118 |
| 33 | Abnormal drinking behavior (HP:0030082) | 2.62237118 |
| 34 | Diplopia (HP:0000651) | 2.61369590 |
| 35 | Abnormality of binocular vision (HP:0011514) | 2.61369590 |
| 36 | Nephronophthisis (HP:0000090) | 2.60308888 |
| 37 | Abnormality of the renal medulla (HP:0100957) | 2.58389021 |
| 38 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.58339480 |
| 39 | Abnormality of the renal cortex (HP:0011035) | 2.54270321 |
| 40 | Attenuation of retinal blood vessels (HP:0007843) | 2.53785039 |
| 41 | Sclerocornea (HP:0000647) | 2.52976039 |
| 42 | Protruding tongue (HP:0010808) | 2.52907378 |
| 43 | Generalized hypopigmentation of hair (HP:0011358) | 2.47742027 |
| 44 | Pancreatic cysts (HP:0001737) | 2.43350103 |
| 45 | Poor eye contact (HP:0000817) | 2.40742362 |
| 46 | Large for gestational age (HP:0001520) | 2.37437507 |
| 47 | Abnormal urine output (HP:0012590) | 2.36101746 |
| 48 | Severe visual impairment (HP:0001141) | 2.35775057 |
| 49 | Abnormal ciliary motility (HP:0012262) | 2.34394527 |
| 50 | Widely spaced teeth (HP:0000687) | 2.34287916 |
| 51 | Abolished electroretinogram (ERG) (HP:0000550) | 2.32891921 |
| 52 | Tubulointerstitial abnormality (HP:0001969) | 2.25558585 |
| 53 | Intestinal atresia (HP:0011100) | 2.24704115 |
| 54 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.22723021 |
| 55 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.22723021 |
| 56 | Abnormality of dentin (HP:0010299) | 2.20620456 |
| 57 | Concave nail (HP:0001598) | 2.20544369 |
| 58 | Abnormality of renal excretion (HP:0011036) | 2.20210828 |
| 59 | Focal seizures (HP:0007359) | 2.19157577 |
| 60 | Proximal tubulopathy (HP:0000114) | 2.18776433 |
| 61 | Focal motor seizures (HP:0011153) | 2.16908641 |
| 62 | Central scotoma (HP:0000603) | 2.16729227 |
| 63 | Abnormality of T cell physiology (HP:0011840) | 2.16008899 |
| 64 | Tinnitus (HP:0000360) | 2.15716765 |
| 65 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.14261642 |
| 66 | Cerebellar dysplasia (HP:0007033) | 2.14240703 |
| 67 | Congenital stationary night blindness (HP:0007642) | 2.13970644 |
| 68 | Polyuria (HP:0000103) | 2.13387386 |
| 69 | Narrow nasal bridge (HP:0000446) | 2.09868686 |
| 70 | Microretrognathia (HP:0000308) | 2.06025176 |
| 71 | Abnormality of the labia minora (HP:0012880) | 2.03748391 |
| 72 | Volvulus (HP:0002580) | 1.97375811 |
| 73 | Pendular nystagmus (HP:0012043) | 1.94516476 |
| 74 | Hypoplasia of the iris (HP:0007676) | 1.94320873 |
| 75 | Abnormal glycosylation (HP:0012345) | 1.94125489 |
| 76 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.94125489 |
| 77 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.94125489 |
| 78 | Abnormal protein glycosylation (HP:0012346) | 1.94125489 |
| 79 | Acute lymphatic leukemia (HP:0006721) | 1.93109417 |
| 80 | Epileptic encephalopathy (HP:0200134) | 1.92863882 |
| 81 | Progressive inability to walk (HP:0002505) | 1.92840046 |
| 82 | Flat occiput (HP:0005469) | 1.92419164 |
| 83 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.91333400 |
| 84 | Small hand (HP:0200055) | 1.91009494 |
| 85 | Cortical visual impairment (HP:0100704) | 1.88386777 |
| 86 | Nonprogressive disorder (HP:0003680) | 1.87152854 |
| 87 | Intellectual disability, progressive (HP:0006887) | 1.86838515 |
| 88 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.86669273 |
| 89 | Atonic seizures (HP:0010819) | 1.79282894 |
| 90 | Broad-based gait (HP:0002136) | 1.77345716 |
| 91 | Aplasia cutis congenita (HP:0001057) | 1.76018332 |
| 92 | Methylmalonic aciduria (HP:0012120) | 1.75240492 |
| 93 | Hemiparesis (HP:0001269) | 1.74631684 |
| 94 | Severe muscular hypotonia (HP:0006829) | 1.73194538 |
| 95 | Patellar aplasia (HP:0006443) | 1.73105490 |
| 96 | Macroorchidism (HP:0000053) | 1.71953596 |
| 97 | Impaired smooth pursuit (HP:0007772) | 1.71811357 |
| 98 | Gonadotropin excess (HP:0000837) | 1.71596464 |
| 99 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.71192550 |
| 100 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.70284189 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TNIK | 4.39930601 |
| 2 | MAP3K4 | 3.58725884 |
| 3 | MAP3K9 | 3.09332426 |
| 4 | MKNK2 | 3.09047577 |
| 5 | MAP3K6 | 2.90277657 |
| 6 | FRK | 2.83423385 |
| 7 | ACVR1B | 2.52790727 |
| 8 | TXK | 2.51196337 |
| 9 | MAP2K7 | 2.49907038 |
| 10 | SIK2 | 2.37744956 |
| 11 | INSRR | 2.33831987 |
| 12 | WNK4 | 2.21219321 |
| 13 | TLK1 | 2.15461702 |
| 14 | TAOK3 | 2.11171788 |
| 15 | PASK | 2.10973161 |
| 16 | BUB1 | 1.97692942 |
| 17 | STK39 | 1.92131474 |
| 18 | MAP4K2 | 1.77823567 |
| 19 | STK16 | 1.71963244 |
| 20 | PTK2B | 1.71672339 |
| 21 | DYRK3 | 1.71178949 |
| 22 | MKNK1 | 1.67132362 |
| 23 | ZAK | 1.63619534 |
| 24 | NUAK1 | 1.58749838 |
| 25 | MARK3 | 1.56721037 |
| 26 | BMPR1B | 1.55750772 |
| 27 | VRK1 | 1.51990350 |
| 28 | VRK2 | 1.41001746 |
| 29 | GRK1 | 1.34952214 |
| 30 | ADRBK2 | 1.28984892 |
| 31 | WNK3 | 1.25610441 |
| 32 | MAP2K4 | 1.21809272 |
| 33 | PLK4 | 1.17848216 |
| 34 | TNK2 | 1.17277019 |
| 35 | DAPK2 | 1.16843502 |
| 36 | IRAK2 | 1.16523798 |
| 37 | PNCK | 1.10808474 |
| 38 | NEK2 | 1.10463492 |
| 39 | BMPR2 | 1.08215437 |
| 40 | TAF1 | 1.08083787 |
| 41 | PRKCH | 1.06730731 |
| 42 | TSSK6 | 1.05938358 |
| 43 | CSF1R | 0.98110822 |
| 44 | ALK | 0.97119629 |
| 45 | PRKCE | 0.96476940 |
| 46 | NTRK3 | 0.95308377 |
| 47 | SIK3 | 0.94301414 |
| 48 | CDC7 | 0.94290168 |
| 49 | PRKCQ | 0.89699173 |
| 50 | PRKCG | 0.87232221 |
| 51 | MST4 | 0.85393829 |
| 52 | ADRBK1 | 0.82700392 |
| 53 | OXSR1 | 0.81849008 |
| 54 | RIPK4 | 0.73891414 |
| 55 | DYRK2 | 0.68594549 |
| 56 | SGK223 | 0.65970699 |
| 57 | SGK494 | 0.65970699 |
| 58 | CDK12 | 0.65090552 |
| 59 | TGFBR1 | 0.64883039 |
| 60 | PBK | 0.63738111 |
| 61 | PIK3CG | 0.62538268 |
| 62 | DAPK1 | 0.60146412 |
| 63 | SGK2 | 0.59672414 |
| 64 | RET | 0.58921669 |
| 65 | MAPK13 | 0.57997544 |
| 66 | RPS6KB2 | 0.53945354 |
| 67 | CAMK4 | 0.53562433 |
| 68 | NLK | 0.52379964 |
| 69 | SIK1 | 0.51229375 |
| 70 | NTRK2 | 0.50645863 |
| 71 | PLK3 | 0.49762790 |
| 72 | CAMK1 | 0.46644833 |
| 73 | MAP2K6 | 0.46101614 |
| 74 | RPS6KA6 | 0.45409656 |
| 75 | CASK | 0.44362556 |
| 76 | CAMK2A | 0.44234707 |
| 77 | PLK1 | 0.43189368 |
| 78 | RPS6KA4 | 0.41831437 |
| 79 | FLT3 | 0.40739557 |
| 80 | MATK | 0.40716238 |
| 81 | CAMK1G | 0.38372634 |
| 82 | CHEK2 | 0.37294470 |
| 83 | SYK | 0.37260484 |
| 84 | SGK3 | 0.37131630 |
| 85 | MAP3K5 | 0.35309189 |
| 86 | CAMKK1 | 0.34289188 |
| 87 | CSNK1D | 0.32894111 |
| 88 | DYRK1A | 0.32469759 |
| 89 | MAP2K1 | 0.31607232 |
| 90 | EIF2AK2 | 0.31191279 |
| 91 | MARK1 | 0.30736641 |
| 92 | ATM | 0.30210313 |
| 93 | SRPK1 | 0.29782842 |
| 94 | AKT3 | 0.29665333 |
| 95 | BRAF | 0.29368847 |
| 96 | STK38 | 0.28975453 |
| 97 | ATR | 0.28925046 |
| 98 | STK38L | 0.28758346 |
| 99 | CSNK1E | 0.27568454 |
| 100 | KIT | 0.27074696 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 4.02197267 |
| 2 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 3.75025487 |
| 3 | Taste transduction_Homo sapiens_hsa04742 | 2.76085219 |
| 4 | Ether lipid metabolism_Homo sapiens_hsa00565 | 2.64714112 |
| 5 | Nicotine addiction_Homo sapiens_hsa05033 | 2.51966704 |
| 6 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.48645039 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.35588884 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.26758802 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.25568534 |
| 10 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.21953938 |
| 11 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 2.14162666 |
| 12 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.13306305 |
| 13 | RNA polymerase_Homo sapiens_hsa03020 | 2.07970099 |
| 14 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.00907879 |
| 15 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.89808291 |
| 16 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.86608964 |
| 17 | Phototransduction_Homo sapiens_hsa04744 | 1.78672521 |
| 18 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.76841384 |
| 19 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.71905774 |
| 20 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.70507087 |
| 21 | GABAergic synapse_Homo sapiens_hsa04727 | 1.60719890 |
| 22 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.56041958 |
| 23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.53480879 |
| 24 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.51179206 |
| 25 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.48777710 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.48745336 |
| 27 | Olfactory transduction_Homo sapiens_hsa04740 | 1.44727897 |
| 28 | Circadian entrainment_Homo sapiens_hsa04713 | 1.42556301 |
| 29 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.42366636 |
| 30 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.36384952 |
| 31 | Homologous recombination_Homo sapiens_hsa03440 | 1.36246695 |
| 32 | Long-term depression_Homo sapiens_hsa04730 | 1.30288511 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.22878779 |
| 34 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.21919304 |
| 35 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.19971376 |
| 36 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.12010124 |
| 37 | RNA degradation_Homo sapiens_hsa03018 | 1.12000444 |
| 38 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.07090404 |
| 39 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.07062403 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.04901527 |
| 41 | Insulin secretion_Homo sapiens_hsa04911 | 1.04132863 |
| 42 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.00481901 |
| 43 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.99933638 |
| 44 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.93088962 |
| 45 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.92951703 |
| 46 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.91650385 |
| 47 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.88937084 |
| 48 | RNA transport_Homo sapiens_hsa03013 | 0.85879518 |
| 49 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.85295964 |
| 50 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.85192557 |
| 51 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.85141853 |
| 52 | Renin secretion_Homo sapiens_hsa04924 | 0.84607255 |
| 53 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.81053799 |
| 54 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.80623875 |
| 55 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.78631619 |
| 56 | Retinol metabolism_Homo sapiens_hsa00830 | 0.77910116 |
| 57 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.76320281 |
| 58 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.66312517 |
| 59 | Salivary secretion_Homo sapiens_hsa04970 | 0.65371261 |
| 60 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.61346277 |
| 61 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.59995938 |
| 62 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.59592525 |
| 63 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.58622447 |
| 64 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.57816729 |
| 65 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57102850 |
| 66 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.56462931 |
| 67 | Peroxisome_Homo sapiens_hsa04146 | 0.55848015 |
| 68 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.53303500 |
| 69 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.51602829 |
| 70 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.51212711 |
| 71 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.51013860 |
| 72 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.50435030 |
| 73 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.50154473 |
| 74 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.49958692 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.49478891 |
| 76 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.48636299 |
| 77 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.48134899 |
| 78 | Platelet activation_Homo sapiens_hsa04611 | 0.47813576 |
| 79 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.45860607 |
| 80 | Base excision repair_Homo sapiens_hsa03410 | 0.44839324 |
| 81 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.43549906 |
| 82 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.40149739 |
| 83 | Metabolic pathways_Homo sapiens_hsa01100 | 0.37613572 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.37232062 |
| 85 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.36154033 |
| 86 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.33436188 |
| 87 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.32035278 |
| 88 | Lysine degradation_Homo sapiens_hsa00310 | 0.29882858 |
| 89 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.29450623 |
| 90 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.28333201 |
| 91 | Long-term potentiation_Homo sapiens_hsa04720 | 0.27843845 |
| 92 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.26824978 |
| 93 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.26375519 |
| 94 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.25598608 |
| 95 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.24848631 |
| 96 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.24171777 |
| 97 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.23539648 |
| 98 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.23461658 |
| 99 | Basal transcription factors_Homo sapiens_hsa03022 | 0.22995866 |
| 100 | Melanoma_Homo sapiens_hsa05218 | 0.22641214 |

