SETP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)8.66252501
2gamma-aminobutyric acid transport (GO:0015812)7.35437736
3detection of light stimulus involved in sensory perception (GO:0050962)6.11127929
4detection of light stimulus involved in visual perception (GO:0050908)6.11127929
5negative regulation of translation, ncRNA-mediated (GO:0040033)5.19697738
6regulation of translation, ncRNA-mediated (GO:0045974)5.19697738
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.19697738
8G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.01207737
9regulation of voltage-gated calcium channel activity (GO:1901385)4.77355706
10phosphatidylinositol acyl-chain remodeling (GO:0036149)4.75898153
11Peyers patch development (GO:0048541)4.34758788
12mucosal-associated lymphoid tissue development (GO:0048537)4.34758788
13chemosensory behavior (GO:0007635)4.30960258
14regulation of posttranscriptional gene silencing (GO:0060147)4.16568425
15regulation of gene silencing by miRNA (GO:0060964)4.16568425
16regulation of gene silencing by RNA (GO:0060966)4.16568425
17phosphatidylserine acyl-chain remodeling (GO:0036150)4.11435616
18monoubiquitinated protein deubiquitination (GO:0035520)3.98783735
19histone H4-K8 acetylation (GO:0043982)3.97655448
20histone H4-K5 acetylation (GO:0043981)3.97655448
21negative regulation of actin filament bundle assembly (GO:0032232)3.95023776
22positive regulation of mRNA catabolic process (GO:0061014)3.92721071
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.83320388
24regulation of sarcomere organization (GO:0060297)3.74377700
25positive regulation of mRNA 3-end processing (GO:0031442)3.72340508
26pseudouridine synthesis (GO:0001522)3.71936780
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.70712859
28positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.67792391
29regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.67792391
30maturation of 5.8S rRNA (GO:0000460)3.63302191
31intra-S DNA damage checkpoint (GO:0031573)3.59461358
32positive regulation of mRNA metabolic process (GO:1903313)3.58920372
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.58559087
34synaptic transmission, glutamatergic (GO:0035249)3.58158800
35gonadal mesoderm development (GO:0007506)3.55564977
36cellular ketone body metabolic process (GO:0046950)3.53463751
37regulation of chromatin binding (GO:0035561)3.50776600
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.47118312
39phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.45959939
40response to misfolded protein (GO:0051788)3.42909540
41regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.41120742
42positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.41120742
43positive regulation of mRNA processing (GO:0050685)3.40310450
44reflex (GO:0060004)3.39389012
45positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.39292474
46regulation of mRNA catabolic process (GO:0061013)3.39166165
47positive regulation of DNA-templated transcription, initiation (GO:2000144)3.37418711
48righting reflex (GO:0060013)3.36724187
49DNA deamination (GO:0045006)3.35070069
50nucleoside diphosphate catabolic process (GO:0009134)3.34106560
51serotonin metabolic process (GO:0042428)3.23560843
52regulation of mRNA 3-end processing (GO:0031440)3.18991815
53kynurenine metabolic process (GO:0070189)3.16122291
54auditory receptor cell stereocilium organization (GO:0060088)3.14371727
55behavioral response to nicotine (GO:0035095)3.12127605
56primary amino compound metabolic process (GO:1901160)3.11171899
57single strand break repair (GO:0000012)3.10325419
58L-methionine salvage (GO:0071267)3.10150915
59L-methionine biosynthetic process (GO:0071265)3.10150915
60amino acid salvage (GO:0043102)3.10150915
61ketone body metabolic process (GO:1902224)3.09115690
62keratinocyte development (GO:0003334)3.04997179
63sodium-independent organic anion transport (GO:0043252)3.02337911
64membrane depolarization during action potential (GO:0086010)3.01971162
65regulation of hippo signaling (GO:0035330)3.01243539
66glutamate receptor signaling pathway (GO:0007215)3.00232633
67photoreceptor cell maintenance (GO:0045494)2.98213282
68cAMP catabolic process (GO:0006198)2.97828237
69response to acidic pH (GO:0010447)2.95239603
70cAMP metabolic process (GO:0046058)2.89804040
71protein-chromophore linkage (GO:0018298)2.85491724
72histone H4-K16 acetylation (GO:0043984)2.85112967
73prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.82729522
74phosphatidylcholine acyl-chain remodeling (GO:0036151)2.78846959
75vocalization behavior (GO:0071625)2.77674309
76ribosome biogenesis (GO:0042254)2.75578020
77regulation of gene silencing (GO:0060968)2.74581937
78retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74544011
79cellular response to pH (GO:0071467)2.70353837
80forebrain neuron differentiation (GO:0021879)2.68190481
81regulation of glutamate receptor signaling pathway (GO:1900449)2.67226201
82cilium or flagellum-dependent cell motility (GO:0001539)2.65948683
83protein K48-linked deubiquitination (GO:0071108)2.62144850
84cyclic nucleotide catabolic process (GO:0009214)2.60493246
85protein localization to synapse (GO:0035418)2.59179392
86glycerophospholipid catabolic process (GO:0046475)2.58132383
87phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.57890131
88behavioral response to ethanol (GO:0048149)2.55530768
89histone-serine phosphorylation (GO:0035404)2.55324209
90water-soluble vitamin biosynthetic process (GO:0042364)2.55032630
91appendage development (GO:0048736)2.54949734
92limb development (GO:0060173)2.54949734
93positive regulation of CREB transcription factor activity (GO:0032793)2.51666050
94spinal cord motor neuron differentiation (GO:0021522)2.50712845
95negative regulation of gene silencing (GO:0060969)2.48945405
96parturition (GO:0007567)2.48081767
97negative regulation by host of viral transcription (GO:0043922)2.46239052
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46045878
99dendritic spine morphogenesis (GO:0060997)2.45143016
100NLS-bearing protein import into nucleus (GO:0006607)2.44791653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.16831732
2VDR_22108803_ChIP-Seq_LS180_Human4.75576573
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.17341828
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01138206
5ZNF274_21170338_ChIP-Seq_K562_Hela2.63301066
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.58344680
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37186990
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31912269
9DROSHA_22980978_ChIP-Seq_HELA_Human2.24868888
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23092188
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20872326
12BCAT_22108803_ChIP-Seq_LS180_Human2.17923768
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.11937309
14REST_21632747_ChIP-Seq_MESCs_Mouse1.98014306
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91850728
16EWS_26573619_Chip-Seq_HEK293_Human1.87344777
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86699909
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86468145
19FUS_26573619_Chip-Seq_HEK293_Human1.74072751
20RNF2_27304074_Chip-Seq_NSC_Mouse1.73595436
21STAT3_23295773_ChIP-Seq_U87_Human1.70709866
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69598667
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69327359
24GBX2_23144817_ChIP-Seq_PC3_Human1.68387197
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66639595
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.65348065
27P300_19829295_ChIP-Seq_ESCs_Human1.64144378
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.62365449
29TDRD3_21172665_ChIP-Seq_MCF-7_Human1.60373308
30ER_23166858_ChIP-Seq_MCF-7_Human1.58415248
31TAF15_26573619_Chip-Seq_HEK293_Human1.58108061
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57707442
33RUNX2_22187159_ChIP-Seq_PCA_Human1.54076383
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47505025
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47223236
36GATA3_21878914_ChIP-Seq_MCF-7_Human1.45874346
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45784120
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45765295
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45765295
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.45463796
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.45139957
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.42042456
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42042456
44SMAD4_21799915_ChIP-Seq_A2780_Human1.40790147
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39964895
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.37946167
47TCF4_23295773_ChIP-Seq_U87_Human1.35137351
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34551465
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34162859
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33055819
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32923797
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31228496
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.30844541
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29875032
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29706550
56CBP_20019798_ChIP-Seq_JUKART_Human1.29578539
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29578539
58IRF1_19129219_ChIP-ChIP_H3396_Human1.27061431
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23876442
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21829824
61TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21524406
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21036373
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19549988
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19512003
65SMAD3_21741376_ChIP-Seq_ESCs_Human1.18089279
66TCF4_22108803_ChIP-Seq_LS180_Human1.17802607
67AR_25329375_ChIP-Seq_VCAP_Human1.17507040
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.17362418
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15150615
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14816676
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.14781382
72TP53_22573176_ChIP-Seq_HFKS_Human1.14363755
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11918892
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11462853
75TP53_16413492_ChIP-PET_HCT116_Human1.09904710
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.09586835
77SMAD4_21741376_ChIP-Seq_HESCs_Human1.08553974
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.08228988
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08163362
80FOXH1_21741376_ChIP-Seq_EPCs_Human1.07082205
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05359080
82JUN_21703547_ChIP-Seq_K562_Human1.05027198
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03577187
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.03235961
85P53_21459846_ChIP-Seq_SAOS-2_Human1.03087518
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02000891
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01465492
88MYC_18940864_ChIP-ChIP_HL60_Human1.01116311
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00220889
90IGF1R_20145208_ChIP-Seq_DFB_Human0.99602564
91KDM2B_26808549_Chip-Seq_REH_Human0.97924714
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97524610
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97465930
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97465930
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.95865062
96AR_21572438_ChIP-Seq_LNCaP_Human0.92930818
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91018217
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.90968549
99AR_20517297_ChIP-Seq_VCAP_Human0.90671107
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90595846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot3.28497571
2MP0003878_abnormal_ear_physiology3.28497571
3MP0002102_abnormal_ear_morphology3.27893127
4MP0005423_abnormal_somatic_nervous3.13354618
5MP0006292_abnormal_olfactory_placode3.01266346
6MP0001501_abnormal_sleep_pattern2.83385121
7MP0009745_abnormal_behavioral_response2.67205626
8MP0002653_abnormal_ependyma_morphology2.58710092
9MP0002822_catalepsy2.55581800
10MP0001188_hyperpigmentation2.52325860
11MP0005645_abnormal_hypothalamus_physiol2.46909249
12MP0000631_abnormal_neuroendocrine_gland2.37091336
13MP0004742_abnormal_vestibular_system2.20609969
14MP0008789_abnormal_olfactory_epithelium2.14179855
15MP0002272_abnormal_nervous_system2.13021304
16MP0008057_abnormal_DNA_replication2.07057939
17MP0003195_calcinosis2.04983518
18MP0005084_abnormal_gallbladder_morpholo1.98648078
19MP0005647_abnormal_sex_gland1.98324558
20MP0001485_abnormal_pinna_reflex1.97094608
21MP0001968_abnormal_touch/_nociception1.93768222
22MP0001486_abnormal_startle_reflex1.93013648
23MP0003950_abnormal_plasma_membrane1.89172460
24MP0003635_abnormal_synaptic_transmissio1.86685968
25MP0008058_abnormal_DNA_repair1.85245706
26MP0002138_abnormal_hepatobiliary_system1.84293883
27MP0009046_muscle_twitch1.82956614
28MP0005551_abnormal_eye_electrophysiolog1.73747272
29MP0003693_abnormal_embryo_hatching1.73415699
30MP0002736_abnormal_nociception_after1.73004936
31MP0002572_abnormal_emotion/affect_behav1.71886550
32MP0001440_abnormal_grooming_behavior1.68677471
33MP0005394_taste/olfaction_phenotype1.67447993
34MP0005499_abnormal_olfactory_system1.67447993
35MP0002733_abnormal_thermal_nociception1.67048093
36MP0000566_synostosis1.64935444
37MP0001905_abnormal_dopamine_level1.64699501
38MP0001348_abnormal_lacrimal_gland1.53180332
39MP0003866_abnormal_defecation1.53128030
40MP0002064_seizures1.52177308
41MP0004147_increased_porphyrin_level1.51871328
42MP0002557_abnormal_social/conspecific_i1.47992367
43MP0002067_abnormal_sensory_capabilities1.44142114
44MP0002735_abnormal_chemical_nociception1.40561886
45MP0001970_abnormal_pain_threshold1.39290663
46MP0003880_abnormal_central_pattern1.36151510
47MP0003119_abnormal_digestive_system1.34494369
48MP0008877_abnormal_DNA_methylation1.33216521
49MP0003567_abnormal_fetal_cardiomyocyte1.31804864
50MP0001963_abnormal_hearing_physiology1.30495932
51MP0005671_abnormal_response_to1.29479506
52MP0002928_abnormal_bile_duct1.27722375
53MP0005386_behavior/neurological_phenoty1.22002407
54MP0004924_abnormal_behavior1.22002407
55MP0003943_abnormal_hepatobiliary_system1.20445028
56MP0008875_abnormal_xenobiotic_pharmacok1.19100211
57MP0000026_abnormal_inner_ear1.18668354
58MP0003011_delayed_dark_adaptation1.14718588
59MP0003252_abnormal_bile_duct1.12805055
60MP0002752_abnormal_somatic_nervous1.12394217
61MP0002938_white_spotting1.12278498
62MP0002184_abnormal_innervation1.12225156
63MP0004885_abnormal_endolymph1.09662676
64MP0003718_maternal_effect1.08968301
65MP0005167_abnormal_blood-brain_barrier1.06685371
66MP0004142_abnormal_muscle_tone1.04259636
67MP0004145_abnormal_muscle_electrophysio1.04047135
68MP0002734_abnormal_mechanical_nocicepti1.00821898
69MP0008872_abnormal_physiological_respon0.98280871
70MP0006276_abnormal_autonomic_nervous0.96361048
71MP0002063_abnormal_learning/memory/cond0.94266002
72MP0003183_abnormal_peptide_metabolism0.94260629
73MP0003698_abnormal_male_reproductive0.93734771
74MP0005379_endocrine/exocrine_gland_phen0.93506900
75MP0000955_abnormal_spinal_cord0.92697936
76MP0010094_abnormal_chromosome_stability0.92469987
77MP0001293_anophthalmia0.91342945
78MP0002210_abnormal_sex_determination0.88437968
79MP0002152_abnormal_brain_morphology0.88110171
80MP0000653_abnormal_sex_gland0.88060814
81MP0000569_abnormal_digit_pigmentation0.83671517
82MP0002909_abnormal_adrenal_gland0.81302067
83MP0001929_abnormal_gametogenesis0.80153094
84MP0000049_abnormal_middle_ear0.79248740
85MP0003115_abnormal_respiratory_system0.78524947
86MP0003111_abnormal_nucleus_morphology0.78335707
87MP0003136_yellow_coat_color0.75285235
88MP0005389_reproductive_system_phenotype0.74196890
89MP0002396_abnormal_hematopoietic_system0.74174792
90MP0002066_abnormal_motor_capabilities/c0.72891150
91MP0001765_abnormal_ion_homeostasis0.70870395
92MP0003315_abnormal_perineum_morphology0.70060897
93MP0000639_abnormal_adrenal_gland0.69788431
94MP0002882_abnormal_neuron_morphology0.69697781
95MP0002693_abnormal_pancreas_physiology0.68094183
96MP0001145_abnormal_male_reproductive0.67615970
97MP0008770_decreased_survivor_rate0.66340502
98MP0001119_abnormal_female_reproductive0.66148515
99MP0005083_abnormal_biliary_tract0.65724744
100MP0002160_abnormal_reproductive_system0.64981212

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)5.11362298
2Facial shape deformation (HP:0011334)4.75728883
3Potter facies (HP:0002009)4.75728883
4Gaze-evoked nystagmus (HP:0000640)4.74508172
5Decreased central vision (HP:0007663)4.69460226
6Abnormality of the pons (HP:0007361)4.26321892
7Genetic anticipation (HP:0003743)4.15728190
8Hyperventilation (HP:0002883)4.07817561
9Abnormality of the diencephalon (HP:0010662)3.89237146
10Duplicated collecting system (HP:0000081)3.65393037
11Progressive cerebellar ataxia (HP:0002073)3.55172849
123-Methylglutaconic aciduria (HP:0003535)3.50110872
13Absent/shortened dynein arms (HP:0200106)3.42485518
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.42485518
15Febrile seizures (HP:0002373)3.25357663
16Retinal dysplasia (HP:0007973)3.24985472
17Tubulointerstitial fibrosis (HP:0005576)3.23675166
18Clumsiness (HP:0002312)3.23311568
19Abnormality of the renal collecting system (HP:0004742)3.19671164
20Abnormality of alanine metabolism (HP:0010916)3.13868991
21Hyperalaninemia (HP:0003348)3.13868991
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.13868991
23Fair hair (HP:0002286)3.13707191
24Increased corneal curvature (HP:0100692)2.90369586
25Keratoconus (HP:0000563)2.90369586
26Inability to walk (HP:0002540)2.87043602
27Hypoplasia of the pons (HP:0012110)2.85990387
28Inappropriate behavior (HP:0000719)2.85286508
29Tubular atrophy (HP:0000092)2.81632321
30Dysmetric saccades (HP:0000641)2.71055211
31Dysautonomia (HP:0002459)2.65047633
32Polydipsia (HP:0001959)2.62237118
33Abnormal drinking behavior (HP:0030082)2.62237118
34Diplopia (HP:0000651)2.61369590
35Abnormality of binocular vision (HP:0011514)2.61369590
36Nephronophthisis (HP:0000090)2.60308888
37Abnormality of the renal medulla (HP:0100957)2.58389021
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58339480
39Abnormality of the renal cortex (HP:0011035)2.54270321
40Attenuation of retinal blood vessels (HP:0007843)2.53785039
41Sclerocornea (HP:0000647)2.52976039
42Protruding tongue (HP:0010808)2.52907378
43Generalized hypopigmentation of hair (HP:0011358)2.47742027
44Pancreatic cysts (HP:0001737)2.43350103
45Poor eye contact (HP:0000817)2.40742362
46Large for gestational age (HP:0001520)2.37437507
47Abnormal urine output (HP:0012590)2.36101746
48Severe visual impairment (HP:0001141)2.35775057
49Abnormal ciliary motility (HP:0012262)2.34394527
50Widely spaced teeth (HP:0000687)2.34287916
51Abolished electroretinogram (ERG) (HP:0000550)2.32891921
52Tubulointerstitial abnormality (HP:0001969)2.25558585
53Intestinal atresia (HP:0011100)2.24704115
54Abnormal respiratory epithelium morphology (HP:0012253)2.22723021
55Abnormal respiratory motile cilium morphology (HP:0005938)2.22723021
56Abnormality of dentin (HP:0010299)2.20620456
57Concave nail (HP:0001598)2.20544369
58Abnormality of renal excretion (HP:0011036)2.20210828
59Focal seizures (HP:0007359)2.19157577
60Proximal tubulopathy (HP:0000114)2.18776433
61Focal motor seizures (HP:0011153)2.16908641
62Central scotoma (HP:0000603)2.16729227
63Abnormality of T cell physiology (HP:0011840)2.16008899
64Tinnitus (HP:0000360)2.15716765
65Abnormal rod and cone electroretinograms (HP:0008323)2.14261642
66Cerebellar dysplasia (HP:0007033)2.14240703
67Congenital stationary night blindness (HP:0007642)2.13970644
68Polyuria (HP:0000103)2.13387386
69Narrow nasal bridge (HP:0000446)2.09868686
70Microretrognathia (HP:0000308)2.06025176
71Abnormality of the labia minora (HP:0012880)2.03748391
72Volvulus (HP:0002580)1.97375811
73Pendular nystagmus (HP:0012043)1.94516476
74Hypoplasia of the iris (HP:0007676)1.94320873
75Abnormal glycosylation (HP:0012345)1.94125489
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94125489
77Abnormal protein N-linked glycosylation (HP:0012347)1.94125489
78Abnormal protein glycosylation (HP:0012346)1.94125489
79Acute lymphatic leukemia (HP:0006721)1.93109417
80Epileptic encephalopathy (HP:0200134)1.92863882
81Progressive inability to walk (HP:0002505)1.92840046
82Flat occiput (HP:0005469)1.92419164
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.91333400
84Small hand (HP:0200055)1.91009494
85Cortical visual impairment (HP:0100704)1.88386777
86Nonprogressive disorder (HP:0003680)1.87152854
87Intellectual disability, progressive (HP:0006887)1.86838515
88Urinary bladder sphincter dysfunction (HP:0002839)1.86669273
89Atonic seizures (HP:0010819)1.79282894
90Broad-based gait (HP:0002136)1.77345716
91Aplasia cutis congenita (HP:0001057)1.76018332
92Methylmalonic aciduria (HP:0012120)1.75240492
93Hemiparesis (HP:0001269)1.74631684
94Severe muscular hypotonia (HP:0006829)1.73194538
95Patellar aplasia (HP:0006443)1.73105490
96Macroorchidism (HP:0000053)1.71953596
97Impaired smooth pursuit (HP:0007772)1.71811357
98Gonadotropin excess (HP:0000837)1.71596464
99Bony spicule pigmentary retinopathy (HP:0007737)1.71192550
100Abnormal respiratory motile cilium physiology (HP:0012261)1.70284189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.39930601
2MAP3K43.58725884
3MAP3K93.09332426
4MKNK23.09047577
5MAP3K62.90277657
6FRK2.83423385
7ACVR1B2.52790727
8TXK2.51196337
9MAP2K72.49907038
10SIK22.37744956
11INSRR2.33831987
12WNK42.21219321
13TLK12.15461702
14TAOK32.11171788
15PASK2.10973161
16BUB11.97692942
17STK391.92131474
18MAP4K21.77823567
19STK161.71963244
20PTK2B1.71672339
21DYRK31.71178949
22MKNK11.67132362
23ZAK1.63619534
24NUAK11.58749838
25MARK31.56721037
26BMPR1B1.55750772
27VRK11.51990350
28VRK21.41001746
29GRK11.34952214
30ADRBK21.28984892
31WNK31.25610441
32MAP2K41.21809272
33PLK41.17848216
34TNK21.17277019
35DAPK21.16843502
36IRAK21.16523798
37PNCK1.10808474
38NEK21.10463492
39BMPR21.08215437
40TAF11.08083787
41PRKCH1.06730731
42TSSK61.05938358
43CSF1R0.98110822
44ALK0.97119629
45PRKCE0.96476940
46NTRK30.95308377
47SIK30.94301414
48CDC70.94290168
49PRKCQ0.89699173
50PRKCG0.87232221
51MST40.85393829
52ADRBK10.82700392
53OXSR10.81849008
54RIPK40.73891414
55DYRK20.68594549
56SGK2230.65970699
57SGK4940.65970699
58CDK120.65090552
59TGFBR10.64883039
60PBK0.63738111
61PIK3CG0.62538268
62DAPK10.60146412
63SGK20.59672414
64RET0.58921669
65MAPK130.57997544
66RPS6KB20.53945354
67CAMK40.53562433
68NLK0.52379964
69SIK10.51229375
70NTRK20.50645863
71PLK30.49762790
72CAMK10.46644833
73MAP2K60.46101614
74RPS6KA60.45409656
75CASK0.44362556
76CAMK2A0.44234707
77PLK10.43189368
78RPS6KA40.41831437
79FLT30.40739557
80MATK0.40716238
81CAMK1G0.38372634
82CHEK20.37294470
83SYK0.37260484
84SGK30.37131630
85MAP3K50.35309189
86CAMKK10.34289188
87CSNK1D0.32894111
88DYRK1A0.32469759
89MAP2K10.31607232
90EIF2AK20.31191279
91MARK10.30736641
92ATM0.30210313
93SRPK10.29782842
94AKT30.29665333
95BRAF0.29368847
96STK380.28975453
97ATR0.28925046
98STK38L0.28758346
99CSNK1E0.27568454
100KIT0.27074696

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.02197267
2Linoleic acid metabolism_Homo sapiens_hsa005913.75025487
3Taste transduction_Homo sapiens_hsa047422.76085219
4Ether lipid metabolism_Homo sapiens_hsa005652.64714112
5Nicotine addiction_Homo sapiens_hsa050332.51966704
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48645039
7Glutamatergic synapse_Homo sapiens_hsa047242.35588884
8Morphine addiction_Homo sapiens_hsa050322.26758802
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25568534
10Butanoate metabolism_Homo sapiens_hsa006502.21953938
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.14162666
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13306305
13RNA polymerase_Homo sapiens_hsa030202.07970099
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00907879
15Ovarian steroidogenesis_Homo sapiens_hsa049131.89808291
16Serotonergic synapse_Homo sapiens_hsa047261.86608964
17Phototransduction_Homo sapiens_hsa047441.78672521
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76841384
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.71905774
20Arachidonic acid metabolism_Homo sapiens_hsa005901.70507087
21GABAergic synapse_Homo sapiens_hsa047271.60719890
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56041958
23One carbon pool by folate_Homo sapiens_hsa006701.53480879
24Nitrogen metabolism_Homo sapiens_hsa009101.51179206
25Tryptophan metabolism_Homo sapiens_hsa003801.48777710
26Cocaine addiction_Homo sapiens_hsa050301.48745336
27Olfactory transduction_Homo sapiens_hsa047401.44727897
28Circadian entrainment_Homo sapiens_hsa047131.42556301
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42366636
30Selenocompound metabolism_Homo sapiens_hsa004501.36384952
31Homologous recombination_Homo sapiens_hsa034401.36246695
32Long-term depression_Homo sapiens_hsa047301.30288511
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22878779
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.21919304
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.19971376
36Propanoate metabolism_Homo sapiens_hsa006401.12010124
37RNA degradation_Homo sapiens_hsa030181.12000444
38Oxytocin signaling pathway_Homo sapiens_hsa049211.07090404
39Dopaminergic synapse_Homo sapiens_hsa047281.07062403
40Purine metabolism_Homo sapiens_hsa002301.04901527
41Insulin secretion_Homo sapiens_hsa049111.04132863
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00481901
43Fat digestion and absorption_Homo sapiens_hsa049750.99933638
44Calcium signaling pathway_Homo sapiens_hsa040200.93088962
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.92951703
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91650385
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.88937084
48RNA transport_Homo sapiens_hsa030130.85879518
49beta-Alanine metabolism_Homo sapiens_hsa004100.85295964
50Cholinergic synapse_Homo sapiens_hsa047250.85192557
51Cardiac muscle contraction_Homo sapiens_hsa042600.85141853
52Renin secretion_Homo sapiens_hsa049240.84607255
53Pyrimidine metabolism_Homo sapiens_hsa002400.81053799
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80623875
55Gastric acid secretion_Homo sapiens_hsa049710.78631619
56Retinol metabolism_Homo sapiens_hsa008300.77910116
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.76320281
58Amphetamine addiction_Homo sapiens_hsa050310.66312517
59Salivary secretion_Homo sapiens_hsa049700.65371261
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61346277
61cAMP signaling pathway_Homo sapiens_hsa040240.59995938
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59592525
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58622447
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57816729
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.57102850
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56462931
67Peroxisome_Homo sapiens_hsa041460.55848015
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.53303500
69Ras signaling pathway_Homo sapiens_hsa040140.51602829
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51212711
71Primary immunodeficiency_Homo sapiens_hsa053400.51013860
72Renin-angiotensin system_Homo sapiens_hsa046140.50435030
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.50154473
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49958692
75Chemical carcinogenesis_Homo sapiens_hsa052040.49478891
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48636299
77Glycerolipid metabolism_Homo sapiens_hsa005610.48134899
78Platelet activation_Homo sapiens_hsa046110.47813576
79N-Glycan biosynthesis_Homo sapiens_hsa005100.45860607
80Base excision repair_Homo sapiens_hsa034100.44839324
81Sphingolipid metabolism_Homo sapiens_hsa006000.43549906
82MAPK signaling pathway_Homo sapiens_hsa040100.40149739
83Metabolic pathways_Homo sapiens_hsa011000.37613572
84Arginine and proline metabolism_Homo sapiens_hsa003300.37232062
85Fatty acid biosynthesis_Homo sapiens_hsa000610.36154033
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.33436188
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32035278
88Lysine degradation_Homo sapiens_hsa003100.29882858
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29450623
90Dilated cardiomyopathy_Homo sapiens_hsa054140.28333201
91Long-term potentiation_Homo sapiens_hsa047200.27843845
92Non-homologous end-joining_Homo sapiens_hsa034500.26824978
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26375519
94Estrogen signaling pathway_Homo sapiens_hsa049150.25598608
95GnRH signaling pathway_Homo sapiens_hsa049120.24848631
96VEGF signaling pathway_Homo sapiens_hsa043700.24171777
97Fanconi anemia pathway_Homo sapiens_hsa034600.23539648
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.23461658
99Basal transcription factors_Homo sapiens_hsa030220.22995866
100Melanoma_Homo sapiens_hsa052180.22641214

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »