SETP20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of phospholipase A2 activity (GO:0032429)6.67207171
2regulation of DNA endoreduplication (GO:0032875)5.76957167
3regulation of cholesterol esterification (GO:0010872)5.29254473
4chaperone-mediated protein transport (GO:0072321)4.67927434
5chromatin remodeling at centromere (GO:0031055)4.67853353
6rRNA modification (GO:0000154)4.67502974
7rRNA methylation (GO:0031167)4.39415382
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.34308673
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.33132967
10establishment of integrated proviral latency (GO:0075713)4.32032196
11mitochondrial calcium ion transport (GO:0006851)4.25657992
12CENP-A containing nucleosome assembly (GO:0034080)4.23379343
13positive regulation of response to oxidative stress (GO:1902884)4.20152144
14positive regulation of cellular response to oxidative stress (GO:1900409)4.20152144
15viral mRNA export from host cell nucleus (GO:0046784)4.11098842
16DNA deamination (GO:0045006)4.03152357
17DNA replication checkpoint (GO:0000076)3.95711880
18regulation of Rac protein signal transduction (GO:0035020)3.94906072
19cullin deneddylation (GO:0010388)3.86164768
20kinetochore organization (GO:0051383)3.77526782
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.76335553
22low-density lipoprotein particle remodeling (GO:0034374)3.71071496
23DNA double-strand break processing (GO:0000729)3.67780219
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66211289
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.61856468
26kinetochore assembly (GO:0051382)3.60260247
27regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.56877450
28protein deneddylation (GO:0000338)3.55642682
29histone exchange (GO:0043486)3.55235991
30leukotriene biosynthetic process (GO:0019370)3.53807220
31mitochondrial RNA metabolic process (GO:0000959)3.52614809
32prenylation (GO:0097354)3.51788408
33protein prenylation (GO:0018342)3.51788408
34pseudouridine synthesis (GO:0001522)3.50822770
35pyrimidine nucleotide catabolic process (GO:0006244)3.48779096
36positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.47832891
37DNA replication-independent nucleosome assembly (GO:0006336)3.38654207
38DNA replication-independent nucleosome organization (GO:0034724)3.38654207
39regulation of oxidative stress-induced neuron death (GO:1903203)3.34849318
40rRNA processing (GO:0006364)3.32600347
41establishment of viral latency (GO:0019043)3.29871137
42regulation of helicase activity (GO:0051095)3.29437113
43maturation of 5.8S rRNA (GO:0000460)3.28169307
44ncRNA catabolic process (GO:0034661)3.24029078
45mRNA cleavage (GO:0006379)3.23756241
46RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.23607814
47somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.19876589
48isotype switching (GO:0045190)3.19876589
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.19876589
50DNA strand elongation involved in DNA replication (GO:0006271)3.18870957
51rRNA metabolic process (GO:0016072)3.18593244
52positive regulation of prostaglandin secretion (GO:0032308)3.16703819
53mitotic metaphase plate congression (GO:0007080)3.13361309
54transcription from mitochondrial promoter (GO:0006390)3.13010885
55L-serine metabolic process (GO:0006563)3.09082767
56ether lipid metabolic process (GO:0046485)3.07789794
57serine family amino acid biosynthetic process (GO:0009070)3.06862345
58DNA strand elongation (GO:0022616)2.99557438
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96468307
60DNA ligation (GO:0006266)2.92574445
61histone mRNA metabolic process (GO:0008334)2.88640626
62negative regulation of Notch signaling pathway (GO:0045746)2.88516341
63bundle of His cell to Purkinje myocyte communication (GO:0086069)2.87426718
64positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.86120069
65regulation of prostaglandin secretion (GO:0032306)2.80980333
66pre-miRNA processing (GO:0031054)2.80538864
67mitotic spindle checkpoint (GO:0071174)2.79045791
68telomere maintenance via telomerase (GO:0007004)2.79037946
69tRNA modification (GO:0006400)2.78610721
70ribosome biogenesis (GO:0042254)2.78293221
71mitochondrial respiratory chain complex assembly (GO:0033108)2.76921128
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76365524
73ncRNA processing (GO:0034470)2.74283337
74drinking behavior (GO:0042756)2.73723676
75ribosomal small subunit biogenesis (GO:0042274)2.73326614
76spindle checkpoint (GO:0031577)2.72272017
77ribonucleoprotein complex biogenesis (GO:0022613)2.70787080
78rRNA transcription (GO:0009303)2.70572500
79ribosomal large subunit biogenesis (GO:0042273)2.67501758
80postreplication repair (GO:0006301)2.67494116
81heterochromatin organization (GO:0070828)2.67023176
82formation of translation preinitiation complex (GO:0001731)2.65599582
83mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64092861
84resolution of meiotic recombination intermediates (GO:0000712)2.63618817
85DNA replication-dependent nucleosome assembly (GO:0006335)2.63588450
86DNA replication-dependent nucleosome organization (GO:0034723)2.63588450
87positive regulation of uterine smooth muscle contraction (GO:0070474)2.62906502
88DNA demethylation (GO:0080111)2.60867682
89positive regulation of chromosome segregation (GO:0051984)2.59986600
90regulation of establishment of cell polarity (GO:2000114)2.58056876
91ATP synthesis coupled proton transport (GO:0015986)2.57836359
92energy coupled proton transport, down electrochemical gradient (GO:0015985)2.57836359
93protein localization to chromosome, centromeric region (GO:0071459)2.57708725
94protein targeting to mitochondrion (GO:0006626)2.55347631
95protein neddylation (GO:0045116)2.55019236
96DNA catabolic process, exonucleolytic (GO:0000738)2.54143865
97cell differentiation involved in metanephros development (GO:0072202)2.54094198
98nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.53892087
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52432283
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.52432283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.63973687
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.55712012
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50015565
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97030236
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.51537284
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.48692909
7E2F7_22180533_ChIP-Seq_HELA_Human3.04763869
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90307358
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84214222
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.82279843
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81494885
12ELK1_19687146_ChIP-ChIP_HELA_Human2.80007143
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73023952
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72522846
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.72052499
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71904378
17VDR_23849224_ChIP-Seq_CD4+_Human2.70562833
18FOXP3_21729870_ChIP-Seq_TREG_Human2.61172902
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46385936
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45231287
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39297107
22MYC_18940864_ChIP-ChIP_HL60_Human2.31257693
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.31134125
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30606200
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21736944
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17700414
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08961480
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.03220188
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.94991652
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89245230
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80759229
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79952747
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79919870
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.77502626
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.77021281
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75365490
37CIITA_25753668_ChIP-Seq_RAJI_Human1.71884720
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.70626225
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69933155
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68832308
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65451172
42ZNF274_21170338_ChIP-Seq_K562_Hela1.63688453
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61935589
44TTF2_22483619_ChIP-Seq_HELA_Human1.59553860
45GABP_19822575_ChIP-Seq_HepG2_Human1.59383632
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59253151
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54213222
48IGF1R_20145208_ChIP-Seq_DFB_Human1.54133549
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53181147
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.52847055
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52726559
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52726559
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52726559
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52572035
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52322673
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51304247
57IRF1_19129219_ChIP-ChIP_H3396_Human1.50401783
58DCP1A_22483619_ChIP-Seq_HELA_Human1.49500926
59FUS_26573619_Chip-Seq_HEK293_Human1.47247894
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46719395
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.41727463
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.40579897
63KDM5A_27292631_Chip-Seq_BREAST_Human1.39715683
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38120079
65XRN2_22483619_ChIP-Seq_HELA_Human1.37478152
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37270012
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36375930
68VDR_22108803_ChIP-Seq_LS180_Human1.33733728
69EWS_26573619_Chip-Seq_HEK293_Human1.31721852
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24104771
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.19033178
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16946921
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.12711851
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12192181
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10402075
76ER_23166858_ChIP-Seq_MCF-7_Human1.10382849
77TAF15_26573619_Chip-Seq_HEK293_Human1.07462785
78P300_19829295_ChIP-Seq_ESCs_Human1.05169206
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03388732
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02943536
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96021371
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95772240
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95693987
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93422338
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93169749
86CBP_20019798_ChIP-Seq_JUKART_Human0.92643778
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92643778
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.92367123
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91659114
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90943173
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88586492
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87966304
93ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87533034
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86202078
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84673341
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83765857
97TP53_22573176_ChIP-Seq_HFKS_Human0.83604496
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81762416
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81167565
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.78266209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.00941295
2MP0008007_abnormal_cellular_replicative4.40142648
3MP0003195_calcinosis4.11753761
4MP0002138_abnormal_hepatobiliary_system2.95548601
5MP0002877_abnormal_melanocyte_morpholog2.94273491
6MP0003111_abnormal_nucleus_morphology2.84503590
7MP0003786_premature_aging2.80128055
8MP0002102_abnormal_ear_morphology2.79953696
9MP0003567_abnormal_fetal_cardiomyocyte2.79067644
10MP0008058_abnormal_DNA_repair2.74577243
11MP0010094_abnormal_chromosome_stability2.65149359
12MP0003123_paternal_imprinting2.60713735
13MP0003693_abnormal_embryo_hatching2.46415249
14MP0008877_abnormal_DNA_methylation2.41673299
15MP0003315_abnormal_perineum_morphology2.33669681
16MP0003787_abnormal_imprinting2.25419238
17MP0002009_preneoplasia2.04981567
18MP0005423_abnormal_somatic_nervous2.00990938
19MP0003121_genomic_imprinting2.00779041
20MP0006072_abnormal_retinal_apoptosis1.96815905
21MP0003077_abnormal_cell_cycle1.81423760
22MP0004957_abnormal_blastocyst_morpholog1.81351419
23MP0005248_abnormal_Harderian_gland1.76654384
24MP0002796_impaired_skin_barrier1.75855091
25MP0006292_abnormal_olfactory_placode1.71170596
26MP0003941_abnormal_skin_development1.68292782
27MP0003806_abnormal_nucleotide_metabolis1.66692915
28MP0002277_abnormal_respiratory_mucosa1.66034434
29MP0006276_abnormal_autonomic_nervous1.64695175
30MP0001293_anophthalmia1.56388990
31MP0002396_abnormal_hematopoietic_system1.56305079
32MP0003119_abnormal_digestive_system1.55024693
33MP0008995_early_reproductive_senescence1.45064784
34MP0006035_abnormal_mitochondrial_morpho1.44723937
35MP0003880_abnormal_central_pattern1.38733233
36MP0009697_abnormal_copulation1.38105675
37MP0001188_hyperpigmentation1.37952178
38MP0005220_abnormal_exocrine_pancreas1.37036282
39MP0000350_abnormal_cell_proliferation1.31744057
40MP0000647_abnormal_sebaceous_gland1.26639226
41MP0002736_abnormal_nociception_after1.25678052
42MP0005379_endocrine/exocrine_gland_phen1.25085801
43MP0001270_distended_abdomen1.22520060
44MP0002837_dystrophic_cardiac_calcinosis1.21881631
45MP0000613_abnormal_salivary_gland1.21724772
46MP0002160_abnormal_reproductive_system1.20303144
47MP0004808_abnormal_hematopoietic_stem1.18790436
48MP0005084_abnormal_gallbladder_morpholo1.18301810
49MP0006036_abnormal_mitochondrial_physio1.17150249
50MP0005365_abnormal_bile_salt1.16853667
51MP0001968_abnormal_touch/_nociception1.14294015
52MP0000358_abnormal_cell_content/1.13284794
53MP0001286_abnormal_eye_development1.11119606
54MP0002697_abnormal_eye_size1.09883645
55MP0005501_abnormal_skin_physiology1.08138393
56MP0005389_reproductive_system_phenotype1.05870323
57MP0001764_abnormal_homeostasis1.02447923
58MP0003221_abnormal_cardiomyocyte_apopto1.01971119
59MP0005193_abnormal_anterior_eye1.01809970
60MP0002928_abnormal_bile_duct1.01221159
61MP0004215_abnormal_myocardial_fiber1.00856388
62MP0003984_embryonic_growth_retardation0.98491622
63MP0005380_embryogenesis_phenotype0.97485514
64MP0001672_abnormal_embryogenesis/_devel0.97485514
65MP0003122_maternal_imprinting0.96474844
66MP0003937_abnormal_limbs/digits/tail_de0.96003895
67MP0002088_abnormal_embryonic_growth/wei0.95791116
68MP0004197_abnormal_fetal_growth/weight/0.93880163
69MP0001730_embryonic_growth_arrest0.92562178
70MP0002132_abnormal_respiratory_system0.92534308
71MP0001919_abnormal_reproductive_system0.91785614
72MP0001145_abnormal_male_reproductive0.89922909
73MP0003186_abnormal_redox_activity0.85844984
74MP0001879_abnormal_lymphatic_vessel0.85257301
75MP0005187_abnormal_penis_morphology0.84955333
76MP0002638_abnormal_pupillary_reflex0.82760856
77MP0001984_abnormal_olfaction0.81939326
78MP0001851_eye_inflammation0.80342755
79MP0005253_abnormal_eye_physiology0.79013979
80MP0000653_abnormal_sex_gland0.76219379
81MP0010030_abnormal_orbit_morphology0.74082891
82MP0001881_abnormal_mammary_gland0.73900634
83MP0003252_abnormal_bile_duct0.73087616
84MP0005391_vision/eye_phenotype0.71706565
85MP0005670_abnormal_white_adipose0.71686605
86MP0000427_abnormal_hair_cycle0.71678618
87MP0004270_analgesia0.71169299
88MP0000313_abnormal_cell_death0.69942898
89MP0000631_abnormal_neuroendocrine_gland0.69132871
90MP0001697_abnormal_embryo_size0.67566346
91MP0002019_abnormal_tumor_incidence0.66938323
92MP0002085_abnormal_embryonic_tissue0.66658021
93MP0002166_altered_tumor_susceptibility0.65115698
94MP0001929_abnormal_gametogenesis0.63788653
95MP0002210_abnormal_sex_determination0.62735514
96MP0005408_hypopigmentation0.60500620
97MP0002177_abnormal_outer_ear0.60334431
98MP0009672_abnormal_birth_weight0.59668399
99MP0005384_cellular_phenotype0.59357387
100MP0001119_abnormal_female_reproductive0.59144195

Predicted human phenotypes

RankGene SetZ-score
1Facial shape deformation (HP:0011334)6.35230823
2Potter facies (HP:0002009)6.35230823
3Widely patent fontanelles and sutures (HP:0004492)5.26313102
4Supernumerary spleens (HP:0009799)3.90818706
5Wide cranial sutures (HP:0010537)3.75508698
6Abnormal biliary tract physiology (HP:0012439)3.74369036
7Bile duct proliferation (HP:0001408)3.74369036
8Pancreatic cysts (HP:0001737)3.40912781
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.29802900
10Abnormal urine output (HP:0012590)3.24171644
11Hypoplasia of the uterus (HP:0000013)3.20445569
12Multifactorial inheritance (HP:0001426)3.16729827
13Abnormality of renal excretion (HP:0011036)3.16292930
14Congenital, generalized hypertrichosis (HP:0004540)3.06800634
15Acute necrotizing encephalopathy (HP:0006965)2.95367208
16Acute encephalopathy (HP:0006846)2.76610615
17Premature ovarian failure (HP:0008209)2.65971652
18Abnormality of chromosome stability (HP:0003220)2.64896970
19Occipital encephalocele (HP:0002085)2.64619281
20True hermaphroditism (HP:0010459)2.62473216
21Hyperphosphaturia (HP:0003109)2.61004672
22Molar tooth sign on MRI (HP:0002419)2.60785467
23Abnormality of midbrain morphology (HP:0002418)2.60785467
24Pancreatic fibrosis (HP:0100732)2.59640677
25Acute lymphatic leukemia (HP:0006721)2.59139179
26Abnormal mitochondria in muscle tissue (HP:0008316)2.53800835
27Horseshoe kidney (HP:0000085)2.53548910
28Abnormal umbilical cord blood vessels (HP:0011403)2.50857452
29Single umbilical artery (HP:0001195)2.50857452
30Abnormality of the fetal cardiovascular system (HP:0010948)2.50857452
31Aplasia/hypoplasia of the uterus (HP:0008684)2.44864461
32Short tibia (HP:0005736)2.42515625
33Progressive macrocephaly (HP:0004481)2.38928519
34Abnormality of the 4th metacarpal (HP:0010012)2.36946522
35Abnormality of the preputium (HP:0100587)2.34507211
36Aplasia/Hypoplasia of the hallux (HP:0008362)2.34029359
37Neoplasm of the adrenal cortex (HP:0100641)2.31720692
38Chromsome breakage (HP:0040012)2.27295012
39Increased circulating renin level (HP:0000848)2.23724038
40Short hallux (HP:0010109)2.23416421
41Hypotension (HP:0002615)2.23119127
42Oligohydramnios (HP:0001562)2.22256063
43Cerebellar dysplasia (HP:0007033)2.21951718
44Bifid tongue (HP:0010297)2.20074180
45Cystic liver disease (HP:0006706)2.19827673
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.19441957
47Aplastic anemia (HP:0001915)2.18073641
48Abolished electroretinogram (ERG) (HP:0000550)2.17328427
49Abnormal pancreas size (HP:0012094)2.17260976
50Abnormality of the labia minora (HP:0012880)2.16652488
51Median cleft lip (HP:0000161)2.13727587
52Adrenal hypoplasia (HP:0000835)2.10867619
53Midline defect of the nose (HP:0004122)2.10289822
54Neoplasm of the adrenal gland (HP:0100631)2.03705720
55Cerebral edema (HP:0002181)2.03076260
56Cleft eyelid (HP:0000625)2.02112018
57Delayed CNS myelination (HP:0002188)1.98814470
58Bone marrow hypocellularity (HP:0005528)1.97317720
59Hypophosphatemic rickets (HP:0004912)1.96426748
60Dandy-Walker malformation (HP:0001305)1.94271578
61Pallor (HP:0000980)1.91912300
62Spinal cord lesions (HP:0100561)1.91647655
63Syringomyelia (HP:0003396)1.91647655
64Anencephaly (HP:0002323)1.91460051
65Abnormality of the umbilical cord (HP:0010881)1.89805638
66Absent eyebrow (HP:0002223)1.89628278
67Fair hair (HP:0002286)1.89072887
68Constricted visual fields (HP:0001133)1.88689652
69Abnormal urine phosphate concentration (HP:0012599)1.88473397
70Abnormal lung lobation (HP:0002101)1.87947383
71Type II lissencephaly (HP:0007260)1.87942181
72Fibular aplasia (HP:0002990)1.86964693
73Abnormality of urine glucose concentration (HP:0011016)1.86379589
74Glycosuria (HP:0003076)1.86379589
75Pancreatic islet-cell hyperplasia (HP:0004510)1.85432689
76Abnormal rod and cone electroretinograms (HP:0008323)1.84651803
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84196583
78Testicular atrophy (HP:0000029)1.82630615
79Pendular nystagmus (HP:0012043)1.80108181
80Abnormality of the ileum (HP:0001549)1.79314551
81Mitochondrial inheritance (HP:0001427)1.78267553
82Type I transferrin isoform profile (HP:0003642)1.77977635
83Macrocytic anemia (HP:0001972)1.77931626
84Oral leukoplakia (HP:0002745)1.77023537
85Sloping forehead (HP:0000340)1.75169820
86Abnormality of the pancreatic islet cells (HP:0006476)1.73602429
87Abnormality of endocrine pancreas physiology (HP:0012093)1.73602429
88Birth length less than 3rd percentile (HP:0003561)1.73109237
89Volvulus (HP:0002580)1.72679542
90Sclerocornea (HP:0000647)1.72364263
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71170692
92Meckel diverticulum (HP:0002245)1.71011249
93Abnormality of secondary sexual hair (HP:0009888)1.68988119
94Abnormality of the axillary hair (HP:0100134)1.68988119
95Increased CSF lactate (HP:0002490)1.68941975
96Palpitations (HP:0001962)1.67014380
97Oculomotor apraxia (HP:0000657)1.64832365
98Chronic bronchitis (HP:0004469)1.64734029
99Cellular immunodeficiency (HP:0005374)1.63796734
100Colon cancer (HP:0003003)1.63716517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.60044929
2MAP3K63.56124996
3CDC72.98737938
4MAP3K42.89959278
5TAF12.86100667
6ACVR1B2.84190160
7PLK22.83822118
8VRK22.81885106
9MAP2K72.64864997
10SRPK12.41229418
11DAPK22.36959418
12BMPR1B2.29751117
13EIF2AK12.16734061
14VRK12.04640522
15MKNK22.04436619
16FES1.94922887
17PIK3CG1.91110755
18PLK31.84864625
19MST41.74438022
20TTK1.73850107
21DYRK31.73518462
22BUB11.72191873
23MAP2K41.70854381
24PLK41.66310761
25MAP3K141.45142756
26STK41.41596126
27MKNK11.41467521
28PRKCI1.38973814
29TEC1.38004366
30NEK21.36683415
31PLK11.34111247
32PBK1.33730144
33PASK1.32268014
34TLK11.25429422
35MAP3K51.20096309
36TSSK61.15901654
37EIF2AK31.14617590
38ATR1.09364134
39DAPK11.02188829
40DAPK31.00195749
41TBK10.99816336
42TGFBR10.99333338
43CHEK20.98147039
44CDK90.93082679
45STK30.92841916
46ITK0.89180241
47ALK0.88189660
48BLK0.87180905
49CDK60.86383187
50RPS6KA40.81297067
51BCKDK0.80147295
52CDK120.79245033
53GRK60.78859047
54AURKB0.77428627
55BTK0.76936254
56WNK40.74604786
57EIF2AK20.70601393
58NUAK10.69730929
59CDK30.69652852
60CSNK1E0.69549676
61CSNK2A20.67582213
62RPS6KA50.66286067
63DYRK20.65538947
64IKBKE0.63023990
65WEE10.62869363
66SYK0.62762601
67CHEK10.61495409
68FRK0.60120799
69NME10.59889553
70ATM0.59477692
71RPS6KB20.59300036
72TNIK0.58481625
73ARAF0.53729177
74MATK0.51784581
75RPS6KL10.50258020
76RPS6KC10.50258020
77STK38L0.50083851
78TXK0.49194116
79STK100.46952546
80RPS6KA60.46061910
81CSNK2A10.45994694
82TIE10.44966089
83AKT20.42599242
84ERN10.41871689
85PRKCE0.40490058
86HCK0.40252935
87ERBB40.38010804
88LYN0.37369400
89CDK70.37367259
90BRD40.36266570
91PRKCQ0.35692312
92CSNK1A1L0.35173915
93CSNK1G30.34770221
94SCYL20.33546280
95CSNK1G10.33101445
96FLT30.32060182
97CDK20.31508945
98NEK10.31228182
99NME20.29900160
100CSNK1G20.29113145

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.83763130
2Non-homologous end-joining_Homo sapiens_hsa034503.54660941
3Ribosome_Homo sapiens_hsa030103.41802958
4Proteasome_Homo sapiens_hsa030503.28306159
5RNA degradation_Homo sapiens_hsa030182.91612931
6Mismatch repair_Homo sapiens_hsa034302.89520080
7DNA replication_Homo sapiens_hsa030302.86730280
8Spliceosome_Homo sapiens_hsa030402.75362236
9Basal transcription factors_Homo sapiens_hsa030222.75078908
10Homologous recombination_Homo sapiens_hsa034402.64648974
11Renin-angiotensin system_Homo sapiens_hsa046142.53504480
12RNA transport_Homo sapiens_hsa030132.24938976
13Base excision repair_Homo sapiens_hsa034102.15993917
14Oxidative phosphorylation_Homo sapiens_hsa001902.15175438
15Protein export_Homo sapiens_hsa030602.12455873
16Nucleotide excision repair_Homo sapiens_hsa034202.06652394
17RNA polymerase_Homo sapiens_hsa030202.04767149
18mRNA surveillance pathway_Homo sapiens_hsa030152.00493978
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98532904
20Fanconi anemia pathway_Homo sapiens_hsa034601.98358603
21Parkinsons disease_Homo sapiens_hsa050121.96059449
22Systemic lupus erythematosus_Homo sapiens_hsa053221.95634305
23One carbon pool by folate_Homo sapiens_hsa006701.66187912
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.64107695
25Pyrimidine metabolism_Homo sapiens_hsa002401.46728716
26Cell cycle_Homo sapiens_hsa041101.42846724
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38187298
28Huntingtons disease_Homo sapiens_hsa050161.36749824
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29579183
30Herpes simplex infection_Homo sapiens_hsa051681.17921391
31Propanoate metabolism_Homo sapiens_hsa006401.16359688
32Asthma_Homo sapiens_hsa053101.14483214
33Type I diabetes mellitus_Homo sapiens_hsa049401.13771414
34p53 signaling pathway_Homo sapiens_hsa041151.12522824
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.05253191
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98116239
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96654620
38Allograft rejection_Homo sapiens_hsa053300.95683806
39Folate biosynthesis_Homo sapiens_hsa007900.95638991
40Autoimmune thyroid disease_Homo sapiens_hsa053200.95627236
41Alzheimers disease_Homo sapiens_hsa050100.95463641
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95345730
43Regulation of autophagy_Homo sapiens_hsa041400.93238633
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91234019
45Alcoholism_Homo sapiens_hsa050340.90827450
46Purine metabolism_Homo sapiens_hsa002300.90736500
47Sulfur relay system_Homo sapiens_hsa041220.87689793
48Graft-versus-host disease_Homo sapiens_hsa053320.86907435
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83333722
50Arachidonic acid metabolism_Homo sapiens_hsa005900.79818096
51Peroxisome_Homo sapiens_hsa041460.74325234
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74190660
53Selenocompound metabolism_Homo sapiens_hsa004500.71324237
54Butanoate metabolism_Homo sapiens_hsa006500.67636949
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66543153
56Epstein-Barr virus infection_Homo sapiens_hsa051690.64122676
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.63143461
58Thyroid cancer_Homo sapiens_hsa052160.61917805
59Steroid biosynthesis_Homo sapiens_hsa001000.61544626
60Viral carcinogenesis_Homo sapiens_hsa052030.60345086
61Glutathione metabolism_Homo sapiens_hsa004800.58856706
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57020003
63Primary immunodeficiency_Homo sapiens_hsa053400.56451925
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52725619
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50267261
66Ether lipid metabolism_Homo sapiens_hsa005650.49112093
67Serotonergic synapse_Homo sapiens_hsa047260.48760185
68Wnt signaling pathway_Homo sapiens_hsa043100.46000847
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45439162
70Metabolic pathways_Homo sapiens_hsa011000.38831683
71beta-Alanine metabolism_Homo sapiens_hsa004100.38423962
72Vitamin B6 metabolism_Homo sapiens_hsa007500.37245626
73Melanoma_Homo sapiens_hsa052180.36848811
74Pyruvate metabolism_Homo sapiens_hsa006200.36801952
75Sulfur metabolism_Homo sapiens_hsa009200.36410930
76Viral myocarditis_Homo sapiens_hsa054160.36166953
77Antigen processing and presentation_Homo sapiens_hsa046120.34570328
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.33585095
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.32579036
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31027557
81Shigellosis_Homo sapiens_hsa051310.30525707
82Oocyte meiosis_Homo sapiens_hsa041140.28995794
83Tryptophan metabolism_Homo sapiens_hsa003800.28770772
84Renin secretion_Homo sapiens_hsa049240.25500347
85Adherens junction_Homo sapiens_hsa045200.24122015
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20490942
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19524924
88Hepatitis C_Homo sapiens_hsa051600.18880966
89Fatty acid degradation_Homo sapiens_hsa000710.18189274
90N-Glycan biosynthesis_Homo sapiens_hsa005100.18186826
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15461957
92Taste transduction_Homo sapiens_hsa047420.14961149
93Pathways in cancer_Homo sapiens_hsa052000.14900471
94HTLV-I infection_Homo sapiens_hsa051660.14754604
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14644477
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.13897613
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.13821208
98B cell receptor signaling pathway_Homo sapiens_hsa046620.12794852
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12665211
100Leishmaniasis_Homo sapiens_hsa051400.12510392

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