SETP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K9 demethylation (GO:0033169)9.11470668
2NIK/NF-kappaB signaling (GO:0038061)6.88184807
3negative regulation of Ras GTPase activity (GO:0034261)5.84742770
4positive regulation of growth hormone secretion (GO:0060124)5.20092026
5response to UV-C (GO:0010225)5.17939984
6I-kappaB phosphorylation (GO:0007252)4.86521454
7regulation of interferon-beta biosynthetic process (GO:0045357)4.63801153
8regulation of RIG-I signaling pathway (GO:0039535)4.52682276
9modulation by symbiont of host defense response (GO:0052031)4.50566669
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.50566669
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.50566669
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.50566669
13modulation by symbiont of host immune response (GO:0052553)4.50566669
14positive regulation by symbiont of host defense response (GO:0052509)4.50566669
15regulation of female receptivity (GO:0045924)4.38783766
16growth hormone secretion (GO:0030252)4.29961955
17negative regulation of smooth muscle cell differentiation (GO:0051151)4.26491504
18water-soluble vitamin biosynthetic process (GO:0042364)4.22425267
19natural killer cell differentiation (GO:0001779)4.17409710
20regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.08409011
21oocyte development (GO:0048599)4.01434607
22B cell proliferation (GO:0042100)3.90801069
23sulfation (GO:0051923)3.89994713
24determination of adult lifespan (GO:0008340)3.87777310
25protein localization to kinetochore (GO:0034501)3.86952053
26regulation of growth hormone secretion (GO:0060123)3.83949393
27DNA replication-dependent nucleosome organization (GO:0034723)3.77929658
28DNA replication-dependent nucleosome assembly (GO:0006335)3.77929658
29negative regulation of telomere maintenance (GO:0032205)3.76725573
30regulation of B cell receptor signaling pathway (GO:0050855)3.75260177
31positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.74079521
32female mating behavior (GO:0060180)3.73211934
33N-terminal protein amino acid acetylation (GO:0006474)3.64802249
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.63953822
35positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.50723841
36establishment of integrated proviral latency (GO:0075713)3.48152631
37regulation of ruffle assembly (GO:1900027)3.45493793
38positive regulation of meiotic cell cycle (GO:0051446)3.31901770
39positive regulation of meiosis (GO:0045836)3.31655338
40positive regulation of prostaglandin secretion (GO:0032308)3.29740911
41regulation of histone H3-K9 methylation (GO:0051570)3.28948202
42regulation of exit from mitosis (GO:0007096)3.25934836
43negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.25586615
44protein K6-linked ubiquitination (GO:0085020)3.22123616
45B cell receptor signaling pathway (GO:0050853)3.17840552
46protein K48-linked deubiquitination (GO:0071108)3.16113867
47organelle disassembly (GO:1903008)3.12699516
48coenzyme catabolic process (GO:0009109)3.12564607
49male meiosis I (GO:0007141)3.10607608
50activation of adenylate cyclase activity (GO:0007190)3.09461580
51multicellular organism reproduction (GO:0032504)3.09035925
52somatic diversification of immunoglobulins (GO:0016445)3.06976686
53gonadal mesoderm development (GO:0007506)3.05970587
54DNA synthesis involved in DNA repair (GO:0000731)3.05365567
55poly(A)+ mRNA export from nucleus (GO:0016973)3.03189552
56transmission of nerve impulse (GO:0019226)3.02158291
57mitotic metaphase plate congression (GO:0007080)3.00703071
58regulation of double-strand break repair via homologous recombination (GO:0010569)2.99901922
59positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.99636290
60response to host immune response (GO:0052572)2.99251451
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99251451
62synaptonemal complex organization (GO:0070193)2.98180374
63nucleosome assembly (GO:0006334)2.97781203
64coenzyme A metabolic process (GO:0015936)2.96522500
65regulation of helicase activity (GO:0051095)2.95926248
66regulation of acrosome reaction (GO:0060046)2.92408604
67mismatch repair (GO:0006298)2.92133380
68positive regulation of response to biotic stimulus (GO:0002833)2.92086018
69establishment of viral latency (GO:0019043)2.88895007
70protein-DNA complex assembly (GO:0065004)2.86104445
71non-recombinational repair (GO:0000726)2.85727570
72double-strand break repair via nonhomologous end joining (GO:0006303)2.85727570
73pyrimidine dimer repair (GO:0006290)2.83092551
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82452709
75synaptonemal complex assembly (GO:0007130)2.81959624
76nucleoside diphosphate catabolic process (GO:0009134)2.81848198
77tryptophan catabolic process (GO:0006569)2.80379085
78indole-containing compound catabolic process (GO:0042436)2.80379085
79indolalkylamine catabolic process (GO:0046218)2.80379085
80positive regulation of histone H3-K4 methylation (GO:0051571)2.78158035
81protein localization to chromosome (GO:0034502)2.77958262
82histone lysine demethylation (GO:0070076)2.76414161
83positive regulation of adenylate cyclase activity (GO:0045762)2.74830511
84glomerular visceral epithelial cell development (GO:0072015)2.73138759
85regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.72876425
86protein K63-linked deubiquitination (GO:0070536)2.69945555
87regulation of telomere maintenance via telomerase (GO:0032210)2.67747797
88regulation of T cell chemotaxis (GO:0010819)2.66021702
89positive regulation of T cell chemotaxis (GO:0010820)2.66021702
90CENP-A containing nucleosome assembly (GO:0034080)2.66001498
91kynurenine metabolic process (GO:0070189)2.65264813
92somatic recombination of immunoglobulin gene segments (GO:0016447)2.64848079
93regulation of telomere maintenance (GO:0032204)2.64723191
94macrophage activation involved in immune response (GO:0002281)2.64048948
95DNA ligation (GO:0006266)2.63849907
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61932929
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.61932929
98telomere maintenance via telomerase (GO:0007004)2.61643250
99indolalkylamine metabolic process (GO:0006586)2.61379709
100regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.61274781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.05756185
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.03931163
3VDR_22108803_ChIP-Seq_LS180_Human3.33921582
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14482634
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.09192890
6E2F7_22180533_ChIP-Seq_HELA_Human3.02413893
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.99708510
8IGF1R_20145208_ChIP-Seq_DFB_Human2.93180972
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85606108
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45408812
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43936602
12IRF1_19129219_ChIP-ChIP_H3396_Human2.42749061
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.41321621
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27398311
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25186078
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20538480
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.12854858
18EWS_26573619_Chip-Seq_HEK293_Human2.07469284
19CBP_20019798_ChIP-Seq_JUKART_Human1.99620143
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.99620143
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95340934
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.93806665
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90138850
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89288910
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.85336174
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.84140560
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80800894
28P300_19829295_ChIP-Seq_ESCs_Human1.73236874
29TAF15_26573619_Chip-Seq_HEK293_Human1.70153222
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68218986
31FUS_26573619_Chip-Seq_HEK293_Human1.67558521
32EZH2_22144423_ChIP-Seq_EOC_Human1.66325801
33TCF4_23295773_ChIP-Seq_U87_Human1.64847785
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64460707
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.62027465
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60428700
37ZNF274_21170338_ChIP-Seq_K562_Hela1.58175994
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.56978723
39MYC_18940864_ChIP-ChIP_HL60_Human1.55822467
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47565199
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47065390
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44153018
43GBX2_23144817_ChIP-Seq_PC3_Human1.41892613
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41795763
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41752184
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40531340
47TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.39836363
48VDR_23849224_ChIP-Seq_CD4+_Human1.37791501
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37665787
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37638805
51TP53_22573176_ChIP-Seq_HFKS_Human1.37638549
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33705443
53CIITA_25753668_ChIP-Seq_RAJI_Human1.33696062
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.31790395
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31260582
56JUN_21703547_ChIP-Seq_K562_Human1.27436077
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26817311
58AR_25329375_ChIP-Seq_VCAP_Human1.26328100
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26132434
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.25398396
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19353407
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18680779
63STAT3_23295773_ChIP-Seq_U87_Human1.17777285
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.14804684
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14483693
66SALL4_22934838_ChIP-ChIP_CD34+_Human1.14237859
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13825778
68FOXP3_21729870_ChIP-Seq_TREG_Human1.13709141
69GATA3_26560356_Chip-Seq_TH1_Human1.12164033
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11323340
71RUNX2_22187159_ChIP-Seq_PCA_Human1.09323921
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.09293708
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.09165305
74NCOR_22424771_ChIP-Seq_293T_Human1.08072905
75SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06091140
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04812849
77BCAT_22108803_ChIP-Seq_LS180_Human1.04747986
78ER_23166858_ChIP-Seq_MCF-7_Human1.04692610
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04564346
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.04323012
81SMAD4_21799915_ChIP-Seq_A2780_Human1.04000735
82SMRT_27268052_Chip-Seq_Bcells_Human1.03680210
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02166628
84RXR_22108803_ChIP-Seq_LS180_Human1.01556121
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00789730
86TCF4_22108803_ChIP-Seq_LS180_Human0.99923872
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98946477
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98810965
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98357367
90MYB_26560356_Chip-Seq_TH2_Human0.98085759
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97627469
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97185488
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95866381
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95517673
95ESET_19884257_ChIP-Seq_ESCs_Mouse0.95043707
96GATA3_26560356_Chip-Seq_TH2_Human0.93550148
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.92946929
98KDM2B_26808549_Chip-Seq_REH_Human0.92099965
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.92078516
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92078516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41469803
2MP0002138_abnormal_hepatobiliary_system4.21108350
3MP0008877_abnormal_DNA_methylation4.04850529
4MP0008058_abnormal_DNA_repair3.11426832
5MP0000015_abnormal_ear_pigmentation3.05702166
6MP0002102_abnormal_ear_morphology3.01296758
7MP0006292_abnormal_olfactory_placode2.95886596
8MP0002822_catalepsy2.62137057
9MP0010094_abnormal_chromosome_stability2.55532478
10MP0006276_abnormal_autonomic_nervous2.34695974
11MP0003183_abnormal_peptide_metabolism2.24472516
12MP0002095_abnormal_skin_pigmentation2.22003343
13MP0002638_abnormal_pupillary_reflex2.16822194
14MP0009384_cardiac_valve_regurgitation2.14589826
15MP0001501_abnormal_sleep_pattern2.11705417
16MP0002160_abnormal_reproductive_system1.99827754
17MP0002909_abnormal_adrenal_gland1.97160158
18MP0003077_abnormal_cell_cycle1.91582480
19MP0001800_abnormal_humoral_immune1.90033798
20MP0005410_abnormal_fertilization1.86053722
21MP0002210_abnormal_sex_determination1.78582811
22MP0003787_abnormal_imprinting1.78347629
23MP0005671_abnormal_response_to1.77668535
24MP0005310_abnormal_salivary_gland1.69790051
25MP0001929_abnormal_gametogenesis1.59543059
26MP0003136_yellow_coat_color1.56750863
27MP0000427_abnormal_hair_cycle1.56456797
28MP0001881_abnormal_mammary_gland1.54475373
29MP0005645_abnormal_hypothalamus_physiol1.50985643
30MP0002277_abnormal_respiratory_mucosa1.49359599
31MP0003786_premature_aging1.47212269
32MP0003763_abnormal_thymus_physiology1.46001943
33MP0000372_irregular_coat_pigmentation1.45510149
34MP0003119_abnormal_digestive_system1.41974169
35MP0002254_reproductive_system_inflammat1.36594269
36MP0006072_abnormal_retinal_apoptosis1.35665423
37MP0003866_abnormal_defecation1.33422769
38MP0000653_abnormal_sex_gland1.32587723
39MP0002736_abnormal_nociception_after1.28891240
40MP0002396_abnormal_hematopoietic_system1.28397852
41MP0001348_abnormal_lacrimal_gland1.28234776
42MP0003698_abnormal_male_reproductive1.27950270
43MP0004957_abnormal_blastocyst_morpholog1.26506036
44MP0001664_abnormal_digestion1.24595885
45MP0000685_abnormal_immune_system1.20378197
46MP0002928_abnormal_bile_duct1.17469140
47MP0002452_abnormal_antigen_presenting1.17096249
48MP0001502_abnormal_circadian_rhythm1.15933528
49MP0004145_abnormal_muscle_electrophysio1.15320858
50MP0000350_abnormal_cell_proliferation1.15297495
51MP0000631_abnormal_neuroendocrine_gland1.15294490
52MP0005387_immune_system_phenotype1.13388082
53MP0001790_abnormal_immune_system1.13388082
54MP0003699_abnormal_female_reproductive1.11674033
55MP0000689_abnormal_spleen_morphology1.10287342
56MP0002723_abnormal_immune_serum1.08994475
57MP0003111_abnormal_nucleus_morphology1.08298665
58MP0001145_abnormal_male_reproductive1.06567347
59MP0000230_abnormal_systemic_arterial1.03254346
60MP0008872_abnormal_physiological_respon1.02341538
61MP0005187_abnormal_penis_morphology1.02129697
62MP0001119_abnormal_female_reproductive1.01133617
63MP0005389_reproductive_system_phenotype0.97075537
64MP0003959_abnormal_lean_body0.96722231
65MP0002177_abnormal_outer_ear0.94053932
66MP0002161_abnormal_fertility/fecundity0.92496713
67MP0000647_abnormal_sebaceous_gland0.91172693
68MP0005253_abnormal_eye_physiology0.89758160
69MP0001835_abnormal_antigen_presentation0.89412700
70MP0005084_abnormal_gallbladder_morpholo0.89027508
71MP0005551_abnormal_eye_electrophysiolog0.88859780
72MP0003121_genomic_imprinting0.88714880
73MP0004742_abnormal_vestibular_system0.86001277
74MP0001485_abnormal_pinna_reflex0.84458359
75MP0002398_abnormal_bone_marrow0.84044182
76MP0003283_abnormal_digestive_organ0.83585857
77MP0010386_abnormal_urinary_bladder0.82841476
78MP0000716_abnormal_immune_system0.82279864
79MP0002420_abnormal_adaptive_immunity0.82156024
80MP0001819_abnormal_immune_cell0.80437349
81MP0009046_muscle_twitch0.79907434
82MP0004142_abnormal_muscle_tone0.79018772
83MP0006035_abnormal_mitochondrial_morpho0.78907134
84MP0004808_abnormal_hematopoietic_stem0.78462715
85MP0003950_abnormal_plasma_membrane0.75762050
86MP0003936_abnormal_reproductive_system0.73622375
87MP0002019_abnormal_tumor_incidence0.73091911
88MP0002127_abnormal_cardiovascular_syste0.71485297
89MP0001529_abnormal_vocalization0.70498603
90MP0001730_embryonic_growth_arrest0.70205101
91MP0002405_respiratory_system_inflammati0.68277917
92MP0001905_abnormal_dopamine_level0.68039842
93MP0005646_abnormal_pituitary_gland0.67252365
94MP0009379_abnormal_foot_pigmentation0.67033276
95MP0005075_abnormal_melanosome_morpholog0.65884330
96MP0003868_abnormal_feces_composition0.64584055
97MP0005220_abnormal_exocrine_pancreas0.63816583
98MP0002693_abnormal_pancreas_physiology0.63487185
99MP0005452_abnormal_adipose_tissue0.62811926
100MP0008057_abnormal_DNA_replication0.60467546

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)6.01905931
2Agammaglobulinemia (HP:0004432)4.69489251
3Premature ovarian failure (HP:0008209)4.63433510
4Focal motor seizures (HP:0011153)4.54669766
5Methylmalonic acidemia (HP:0002912)3.73710625
6Recurrent bronchitis (HP:0002837)3.58777812
7Cerebral hypomyelination (HP:0006808)3.42958125
8Severe visual impairment (HP:0001141)3.30456776
9Dysphonia (HP:0001618)3.12678277
10Cellulitis (HP:0100658)3.04044429
11Gastrointestinal stroma tumor (HP:0100723)2.90095279
12Hyperglycinemia (HP:0002154)2.82669936
13Visual hallucinations (HP:0002367)2.82461009
14Chronic sinusitis (HP:0011109)2.78835662
15Prostate neoplasm (HP:0100787)2.73241341
16Abnormality of the labia minora (HP:0012880)2.72804673
17Facial cleft (HP:0002006)2.70565726
18Methylmalonic aciduria (HP:0012120)2.67238227
19Abnormality of chromosome stability (HP:0003220)2.56590648
20Type I transferrin isoform profile (HP:0003642)2.54174497
21Bronchitis (HP:0012387)2.52809403
22Absence seizures (HP:0002121)2.51945122
23Growth hormone deficiency (HP:0000824)2.47637134
24Congenital primary aphakia (HP:0007707)2.47023166
25Recurrent pneumonia (HP:0006532)2.46216821
26Increased hepatocellular lipid droplets (HP:0006565)2.45841402
27Hypobetalipoproteinemia (HP:0003563)2.44465414
28Genital tract atresia (HP:0001827)2.43929650
29Medial flaring of the eyebrow (HP:0010747)2.42200342
30Papillary thyroid carcinoma (HP:0002895)2.41553162
31Papilloma (HP:0012740)2.40425182
32Verrucae (HP:0200043)2.40425182
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35498759
34Gait imbalance (HP:0002141)2.34379838
35Chromsome breakage (HP:0040012)2.34028987
36Retinitis pigmentosa (HP:0000510)2.31204003
37Peripheral hypomyelination (HP:0007182)2.24044000
38Abnormality of the vitamin B12 metabolism (HP:0004341)2.22473995
39Oligodactyly (hands) (HP:0001180)2.22184423
40Spastic paraparesis (HP:0002313)2.18077890
41Abnormal number of incisors (HP:0011064)2.15932104
42Nephrogenic diabetes insipidus (HP:0009806)2.15776887
43Lipid accumulation in hepatocytes (HP:0006561)2.15712708
44Abnormality of serine family amino acid metabolism (HP:0010894)2.11252381
45Abnormality of glycine metabolism (HP:0010895)2.11252381
46Dialeptic seizures (HP:0011146)2.10083581
47Tubulointerstitial abnormality (HP:0001969)2.05751837
48Poor speech (HP:0002465)2.05392372
49Acanthocytosis (HP:0001927)2.04724859
50Bilateral microphthalmos (HP:0007633)2.04170126
51Poor coordination (HP:0002370)2.03791306
52Vaginal atresia (HP:0000148)2.03721405
53Nonimmune hydrops fetalis (HP:0001790)2.03582985
54Clubbing of toes (HP:0100760)2.03523345
55Abnormal auditory evoked potentials (HP:0006958)2.03201252
56Hypoplasia of the pons (HP:0012110)2.03036294
57Recurrent sinusitis (HP:0011108)2.02842998
58Aplasia/Hypoplasia of the tibia (HP:0005772)1.98325393
59Abnormality of the nasal septum (HP:0000419)1.97962698
60Median cleft lip (HP:0000161)1.95765974
61Abnormality of vitamin B metabolism (HP:0004340)1.94423481
62Recurrent lower respiratory tract infections (HP:0002783)1.92813682
63Slow saccadic eye movements (HP:0000514)1.91234030
64Lymphopenia (HP:0001888)1.90930687
65Microvesicular hepatic steatosis (HP:0001414)1.90770400
66Abnormality of the renal cortex (HP:0011035)1.89917180
67Abnormal protein N-linked glycosylation (HP:0012347)1.88653784
68Abnormal protein glycosylation (HP:0012346)1.88653784
69Abnormal glycosylation (HP:0012345)1.88653784
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88653784
71Tubulointerstitial fibrosis (HP:0005576)1.88475766
72Duodenal stenosis (HP:0100867)1.88273726
73Small intestinal stenosis (HP:0012848)1.88273726
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88009886
75Abnormal hair whorl (HP:0010721)1.87749340
76Abnormal albumin level (HP:0012116)1.86002894
77Hypoalbuminemia (HP:0003073)1.86002894
78Hypoplastic left heart (HP:0004383)1.85858292
79Amelogenesis imperfecta (HP:0000705)1.84110427
80Delayed CNS myelination (HP:0002188)1.84002035
81Cellular immunodeficiency (HP:0005374)1.83005115
82Osteomyelitis (HP:0002754)1.82970719
83Mitochondrial inheritance (HP:0001427)1.81981693
84Spontaneous abortion (HP:0005268)1.81848409
85Reduced antithrombin III activity (HP:0001976)1.80428931
86Retinal atrophy (HP:0001105)1.78594230
87Tubulointerstitial nephritis (HP:0001970)1.77305379
88Abnormality of the ileum (HP:0001549)1.76992834
89Aplasia/Hypoplasia of the lens (HP:0008063)1.76855665
90Increased CSF lactate (HP:0002490)1.76464902
91CNS hypomyelination (HP:0003429)1.76289117
92Nephronophthisis (HP:0000090)1.74892320
93Submucous cleft hard palate (HP:0000176)1.72184845
94Hepatic necrosis (HP:0002605)1.71767376
95Short tibia (HP:0005736)1.70978188
96Metaphyseal dysplasia (HP:0100255)1.70912364
97Tubular atrophy (HP:0000092)1.69280563
98Hepatocellular necrosis (HP:0001404)1.67038757
99Congenital sensorineural hearing impairment (HP:0008527)1.66926373
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66896598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.12077375
2VRK13.47961738
3CDK123.47835244
4MST43.20135544
5TLK13.14181762
6SRPK12.65489271
7TNIK2.55089051
8STK162.51613375
9PINK12.48610612
10CDC72.47981786
11MAP3K122.42681830
12IKBKE2.40456988
13PRKD32.28876386
14IRAK42.20542304
15MAP3K42.15564001
16BUB12.07660795
17MAP3K62.00350593
18STK391.98042580
19CDK191.95997317
20KDR1.87280581
21PLK41.53554926
22BCKDK1.50069352
23VRK21.41059464
24TESK21.32020037
25BLK1.29438359
26MAP4K11.28708876
27EIF2AK31.28543959
28FRK1.27426609
29AURKA1.17669843
30NUAK11.15484421
31RPS6KA51.12740506
32OXSR11.12083862
33DAPK11.11471984
34CHEK21.04781982
35PLK31.04165805
36SYK1.03030648
37TTK0.97801216
38TEC0.96463563
39ARAF0.92881801
40RPS6KA40.87058761
41RAF10.86638834
42PBK0.84868327
43MAP2K10.84547491
44BMPR1B0.84019550
45MAPK130.83440519
46IRAK20.81702173
47STK38L0.81668339
48CAMKK20.80723731
49PKN10.79452286
50MAPKAPK30.76339451
51ATR0.74011055
52MAPK150.73823808
53LATS10.68084280
54AURKB0.67845391
55PIM10.64735454
56STK40.64516036
57TXK0.63771470
58TAOK30.63115222
59ADRBK10.62629858
60CSNK1D0.61440971
61PLK10.61059857
62MYLK0.59799385
63CHEK10.59517142
64DDR20.58496975
65MKNK10.57505299
66MKNK20.56878198
67WNK30.55977297
68TRIM280.51789970
69BRAF0.51548979
70LYN0.51172957
71CSNK2A10.50382540
72CAMK10.50293406
73CSNK2A20.50017799
74NEK90.49288758
75ADRBK20.48901680
76PRKCH0.47288856
77CDK30.46775252
78MAP3K30.46495740
79PRKCQ0.43755676
80PIM20.43525424
81MAPKAPK20.43144261
82CDK20.42535031
83TIE10.41780297
84GRK10.41185692
85PRKDC0.40061532
86MAP3K50.39524312
87ERBB40.37963875
88MAPK120.37671958
89ACVR1B0.37649649
90LIMK10.37515119
91TSSK60.36804945
92ATM0.35324795
93PRKG10.32591096
94PRKACA0.31469729
95NLK0.29899190
96CAMK40.29212066
97MAP2K70.28202066
98MARK20.27313354
99PDK20.26722357
100PIK3CA0.25990231

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034505.00563091
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.57859469
3Systemic lupus erythematosus_Homo sapiens_hsa053223.24380704
4Homologous recombination_Homo sapiens_hsa034402.82451088
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.72171796
6Primary immunodeficiency_Homo sapiens_hsa053402.57829043
7Mismatch repair_Homo sapiens_hsa034302.47160907
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44027384
9Fanconi anemia pathway_Homo sapiens_hsa034602.30779593
10RNA polymerase_Homo sapiens_hsa030202.03558470
11Allograft rejection_Homo sapiens_hsa053301.97113298
12Alcoholism_Homo sapiens_hsa050341.96790222
13Graft-versus-host disease_Homo sapiens_hsa053321.94186130
14Vitamin B6 metabolism_Homo sapiens_hsa007501.92547448
15Autoimmune thyroid disease_Homo sapiens_hsa053201.91315428
16Basal transcription factors_Homo sapiens_hsa030221.90368654
17Antigen processing and presentation_Homo sapiens_hsa046121.86393981
18Asthma_Homo sapiens_hsa053101.78353922
19Proteasome_Homo sapiens_hsa030501.76606937
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64084891
21DNA replication_Homo sapiens_hsa030301.58441795
22RNA degradation_Homo sapiens_hsa030181.57291008
23Base excision repair_Homo sapiens_hsa034101.52300140
24Pyrimidine metabolism_Homo sapiens_hsa002401.51904132
25Type I diabetes mellitus_Homo sapiens_hsa049401.43994167
26One carbon pool by folate_Homo sapiens_hsa006701.43706351
27Spliceosome_Homo sapiens_hsa030401.41671626
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39893354
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34407388
30Selenocompound metabolism_Homo sapiens_hsa004501.32527749
31Herpes simplex infection_Homo sapiens_hsa051681.27484940
32RNA transport_Homo sapiens_hsa030131.21434692
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14485510
34Ribosome_Homo sapiens_hsa030101.13556390
35Purine metabolism_Homo sapiens_hsa002301.11634952
36Parkinsons disease_Homo sapiens_hsa050121.09581693
37Oxidative phosphorylation_Homo sapiens_hsa001901.06256620
38Tryptophan metabolism_Homo sapiens_hsa003801.03917154
39mRNA surveillance pathway_Homo sapiens_hsa030151.02710380
40Phototransduction_Homo sapiens_hsa047440.98715886
41Serotonergic synapse_Homo sapiens_hsa047260.93181625
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.92946136
43Huntingtons disease_Homo sapiens_hsa050160.89958780
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88384757
45Propanoate metabolism_Homo sapiens_hsa006400.87821806
46Chemical carcinogenesis_Homo sapiens_hsa052040.84297181
47B cell receptor signaling pathway_Homo sapiens_hsa046620.84147612
48Dorso-ventral axis formation_Homo sapiens_hsa043200.81940911
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.80356830
50Taste transduction_Homo sapiens_hsa047420.80251327
51Epstein-Barr virus infection_Homo sapiens_hsa051690.76270319
52Olfactory transduction_Homo sapiens_hsa047400.76201904
53Peroxisome_Homo sapiens_hsa041460.76068410
54Viral carcinogenesis_Homo sapiens_hsa052030.73870511
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.73661337
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.71847940
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.71227966
58Sulfur relay system_Homo sapiens_hsa041220.69566906
59Hematopoietic cell lineage_Homo sapiens_hsa046400.68180133
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67622360
61Cell cycle_Homo sapiens_hsa041100.65878273
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63526311
63Measles_Homo sapiens_hsa051620.60283920
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59061269
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59050558
66Linoleic acid metabolism_Homo sapiens_hsa005910.56605900
67p53 signaling pathway_Homo sapiens_hsa041150.56395322
68Viral myocarditis_Homo sapiens_hsa054160.53106041
69Oocyte meiosis_Homo sapiens_hsa041140.53030772
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52979925
71Rheumatoid arthritis_Homo sapiens_hsa053230.50095571
72Morphine addiction_Homo sapiens_hsa050320.48214021
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43853607
74Cardiac muscle contraction_Homo sapiens_hsa042600.43623032
75Salivary secretion_Homo sapiens_hsa049700.41606976
76Influenza A_Homo sapiens_hsa051640.41177898
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39997136
78HTLV-I infection_Homo sapiens_hsa051660.39481602
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38248451
80Calcium signaling pathway_Homo sapiens_hsa040200.37676854
81Nucleotide excision repair_Homo sapiens_hsa034200.36199967
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35564037
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33873338
84Sulfur metabolism_Homo sapiens_hsa009200.33693173
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33546552
86Pyruvate metabolism_Homo sapiens_hsa006200.33168205
87Leishmaniasis_Homo sapiens_hsa051400.32998258
88Retinol metabolism_Homo sapiens_hsa008300.30069853
89GABAergic synapse_Homo sapiens_hsa047270.29643404
90Dopaminergic synapse_Homo sapiens_hsa047280.26931943
91Protein export_Homo sapiens_hsa030600.25887618
92Glutamatergic synapse_Homo sapiens_hsa047240.24534266
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24475027
94Collecting duct acid secretion_Homo sapiens_hsa049660.24105201
95Cholinergic synapse_Homo sapiens_hsa047250.23839658
96Butanoate metabolism_Homo sapiens_hsa006500.23773404
97Glutathione metabolism_Homo sapiens_hsa004800.22789055
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19623791
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17632078
100Metabolic pathways_Homo sapiens_hsa011000.16182807

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