SETP22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA modification (GO:0000154)6.24380278
2neurofilament cytoskeleton organization (GO:0060052)5.63904470
3rRNA methylation (GO:0031167)5.45468355
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.43433254
5chaperone-mediated protein transport (GO:0072321)4.83264589
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71047659
7negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.70478780
8ribosomal small subunit biogenesis (GO:0042274)4.68045822
9ATP synthesis coupled proton transport (GO:0015986)4.52535954
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.52535954
11ribosomal large subunit biogenesis (GO:0042273)4.50324389
12proteasome assembly (GO:0043248)4.37444010
13response to pheromone (GO:0019236)4.28147731
14DNA deamination (GO:0045006)4.12933778
15regulation of mitochondrial translation (GO:0070129)4.06314849
16ribonucleoprotein complex biogenesis (GO:0022613)3.94115723
17microtubule depolymerization (GO:0007019)3.92514123
18inner mitochondrial membrane organization (GO:0007007)3.91524396
19negative regulation of DNA recombination (GO:0045910)3.86525835
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85763448
21ribosomal small subunit assembly (GO:0000028)3.82351838
227-methylguanosine mRNA capping (GO:0006370)3.74983364
23termination of RNA polymerase I transcription (GO:0006363)3.67049605
247-methylguanosine RNA capping (GO:0009452)3.64728294
25RNA capping (GO:0036260)3.64728294
26rRNA processing (GO:0006364)3.63528846
27DNA damage response, detection of DNA damage (GO:0042769)3.58688244
28maturation of 5.8S rRNA (GO:0000460)3.56485488
29ribosome biogenesis (GO:0042254)3.55613322
30transcription elongation from RNA polymerase I promoter (GO:0006362)3.54669939
31transcription from RNA polymerase I promoter (GO:0006360)3.50788954
32DNA strand renaturation (GO:0000733)3.50539025
33respiratory electron transport chain (GO:0022904)3.47204431
34translational termination (GO:0006415)3.46054512
35viral transcription (GO:0019083)3.46052841
36positive regulation of amino acid transport (GO:0051957)3.45638103
37regulation of double-strand break repair via homologous recombination (GO:0010569)3.44344956
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43497066
39cellular component biogenesis (GO:0044085)3.43493065
40pseudouridine synthesis (GO:0001522)3.41976996
41neurotransmitter catabolic process (GO:0042135)3.40267795
42spliceosomal snRNP assembly (GO:0000387)3.39804838
43rRNA metabolic process (GO:0016072)3.39783818
44DNA replication-dependent nucleosome organization (GO:0034723)3.39674206
45DNA replication-dependent nucleosome assembly (GO:0006335)3.39674206
46maturation of SSU-rRNA (GO:0030490)3.39643665
47electron transport chain (GO:0022900)3.38018390
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34848749
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32979619
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32052614
51ribosome assembly (GO:0042255)3.30637579
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29262636
53termination of RNA polymerase III transcription (GO:0006386)3.24221391
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.24221391
55formation of translation preinitiation complex (GO:0001731)3.22564120
56negative regulation of RNA splicing (GO:0033119)3.19611406
57negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.19090082
58transcription initiation from RNA polymerase I promoter (GO:0006361)3.10776241
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09999783
60oxidative phosphorylation (GO:0006119)3.09777067
61translational elongation (GO:0006414)3.05944585
62ncRNA catabolic process (GO:0034661)3.04648902
63cotranslational protein targeting to membrane (GO:0006613)2.98970319
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98841458
65peptidyl-histidine modification (GO:0018202)2.98609596
66histone mRNA metabolic process (GO:0008334)2.98277002
67negative regulation of mRNA processing (GO:0050686)2.97406701
68negative regulation of mRNA metabolic process (GO:1903312)2.96771274
69translation (GO:0006412)2.96427747
70establishment of integrated proviral latency (GO:0075713)2.95598047
71transcription from mitochondrial promoter (GO:0006390)2.95190743
72protein targeting to ER (GO:0045047)2.93218043
73mitochondrial respiratory chain complex assembly (GO:0033108)2.92933267
74intracellular protein transmembrane import (GO:0044743)2.92288073
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.91372901
76NADH dehydrogenase complex assembly (GO:0010257)2.91372901
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91372901
78regulation of helicase activity (GO:0051095)2.90567611
79positive regulation of response to oxidative stress (GO:1902884)2.89649017
80positive regulation of cellular response to oxidative stress (GO:1900409)2.89649017
81DNA replication checkpoint (GO:0000076)2.88182272
82cellular protein complex disassembly (GO:0043624)2.87330818
83DNA strand elongation involved in DNA replication (GO:0006271)2.85685427
84anterograde axon cargo transport (GO:0008089)2.85092575
85translational initiation (GO:0006413)2.83367047
86protein complex biogenesis (GO:0070271)2.83029575
87glycerol ether metabolic process (GO:0006662)2.82771242
88pyrimidine nucleotide catabolic process (GO:0006244)2.82119072
89DNA-templated transcription, termination (GO:0006353)2.81846476
90protein localization to endoplasmic reticulum (GO:0070972)2.81240993
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80594634
92non-recombinational repair (GO:0000726)2.78646796
93double-strand break repair via nonhomologous end joining (GO:0006303)2.78646796
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.77847982
95protein targeting to mitochondrion (GO:0006626)2.77086681
96DNA ligation (GO:0006266)2.76365671
97histone exchange (GO:0043486)2.74612559
98ATP biosynthetic process (GO:0006754)2.70991842
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69083260
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69083260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52630031
2E2F7_22180533_ChIP-Seq_HELA_Human3.94507173
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.79568724
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75609784
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.72286729
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.67439897
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.56563067
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.40197326
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12844016
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.00547229
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98275921
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.95110532
13IRF1_19129219_ChIP-ChIP_H3396_Human2.86445260
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84287571
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83817216
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78365854
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65610192
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58871032
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44612950
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.42039556
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41656442
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30056582
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24098964
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20766772
25VDR_23849224_ChIP-Seq_CD4+_Human2.18229670
26MYC_18940864_ChIP-ChIP_HL60_Human2.17941379
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14469290
28XRN2_22483619_ChIP-Seq_HELA_Human2.13710876
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12825250
30TTF2_22483619_ChIP-Seq_HELA_Human2.08293017
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.02949161
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.94426466
33DCP1A_22483619_ChIP-Seq_HELA_Human1.93193722
34SOX2_16153702_ChIP-ChIP_HESCs_Human1.92781163
35FOXP3_21729870_ChIP-Seq_TREG_Human1.86885565
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81616427
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78148089
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77049955
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73719504
40ELK1_19687146_ChIP-ChIP_HELA_Human1.68256968
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67898359
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.63007878
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62153376
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.61822755
45ZNF274_21170338_ChIP-Seq_K562_Hela1.60852726
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.60044188
47GABP_19822575_ChIP-Seq_HepG2_Human1.56270181
48VDR_22108803_ChIP-Seq_LS180_Human1.52500327
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.52325840
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51166628
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49947217
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40165807
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.35962103
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35640452
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.31378750
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25354329
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25112618
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23877396
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20592935
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.19675582
61FUS_26573619_Chip-Seq_HEK293_Human1.19509343
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18832453
63TAF15_26573619_Chip-Seq_HEK293_Human1.16564392
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.14222566
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13641827
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11473007
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11312438
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05718975
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04869230
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03945463
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02709163
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98308849
73BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96406605
74MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96022284
75SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95819020
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95811678
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.95348410
78EWS_26573619_Chip-Seq_HEK293_Human0.94227964
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91887497
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91461244
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90590157
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89144364
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88746059
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88618706
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88513015
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86691388
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82528857
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81264664
89FOXP1_21924763_ChIP-Seq_HESCs_Human0.79668138
90KDM5A_27292631_Chip-Seq_BREAST_Human0.78595823
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77347203
92HTT_18923047_ChIP-ChIP_STHdh_Human0.77266927
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76342494
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75585106
95SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75353848
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74550271
97ERG_20517297_ChIP-Seq_VCAP_Human0.74455865
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74046601
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74012442
100ZNF263_19887448_ChIP-Seq_K562_Human0.72937981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.26921737
2MP0008057_abnormal_DNA_replication3.81266952
3MP0002735_abnormal_chemical_nociception3.51840584
4MP0004957_abnormal_blastocyst_morpholog3.34575546
5MP0002638_abnormal_pupillary_reflex3.32543722
6MP0006292_abnormal_olfactory_placode3.14893038
7MP0003693_abnormal_embryo_hatching2.74693100
8MP0000537_abnormal_urethra_morphology2.70834990
9MP0003111_abnormal_nucleus_morphology2.55646091
10MP0003878_abnormal_ear_physiology2.53135205
11MP0005377_hearing/vestibular/ear_phenot2.53135205
12MP0001293_anophthalmia2.16386132
13MP0008058_abnormal_DNA_repair2.05457023
14MP0008932_abnormal_embryonic_tissue1.91425483
15MP0010094_abnormal_chromosome_stability1.90280821
16MP0009379_abnormal_foot_pigmentation1.87345287
17MP0004145_abnormal_muscle_electrophysio1.86917261
18MP0008995_early_reproductive_senescence1.84826709
19MP0003119_abnormal_digestive_system1.84594837
20MP0005410_abnormal_fertilization1.84537921
21MP0003786_premature_aging1.84236316
22MP0006035_abnormal_mitochondrial_morpho1.83068622
23MP0002938_white_spotting1.81239962
24MP0005085_abnormal_gallbladder_physiolo1.81198045
25MP0002277_abnormal_respiratory_mucosa1.79991637
26MP0003941_abnormal_skin_development1.62697290
27MP0001529_abnormal_vocalization1.62287184
28MP0001730_embryonic_growth_arrest1.61900187
29MP0000049_abnormal_middle_ear1.60698374
30MP0003567_abnormal_fetal_cardiomyocyte1.58730126
31MP0001188_hyperpigmentation1.57611345
32MP0003122_maternal_imprinting1.56951911
33MP0003718_maternal_effect1.56421711
34MP0008007_abnormal_cellular_replicative1.54703556
35MP0003077_abnormal_cell_cycle1.52342729
36MP0002697_abnormal_eye_size1.46256784
37MP0001849_ear_inflammation1.40881720
38MP0006036_abnormal_mitochondrial_physio1.40544285
39MP0002249_abnormal_larynx_morphology1.36774288
40MP0003121_genomic_imprinting1.34178003
41MP0006276_abnormal_autonomic_nervous1.30164098
42MP0009697_abnormal_copulation1.26409483
43MP0004197_abnormal_fetal_growth/weight/1.24231185
44MP0001929_abnormal_gametogenesis1.21905674
45MP0002736_abnormal_nociception_after1.17982020
46MP0003890_abnormal_embryonic-extraembry1.17503196
47MP0003698_abnormal_male_reproductive1.17125174
48MP0002234_abnormal_pharynx_morphology1.16609434
49MP0001661_extended_life_span1.16073488
50MP0002210_abnormal_sex_determination1.10556961
51MP0001286_abnormal_eye_development1.06624251
52MP0003937_abnormal_limbs/digits/tail_de1.04915016
53MP0002085_abnormal_embryonic_tissue1.00715490
54MP0000350_abnormal_cell_proliferation1.00550019
55MP0002092_abnormal_eye_morphology1.00345899
56MP0005391_vision/eye_phenotype0.99215485
57MP0004742_abnormal_vestibular_system0.98998219
58MP0002282_abnormal_trachea_morphology0.92997479
59MP0002084_abnormal_developmental_patter0.92853215
60MP0000653_abnormal_sex_gland0.89816058
61MP0003806_abnormal_nucleotide_metabolis0.89248763
62MP0001346_abnormal_lacrimal_gland0.88833342
63MP0008875_abnormal_xenobiotic_pharmacok0.88530963
64MP0001145_abnormal_male_reproductive0.88378703
65MP0002161_abnormal_fertility/fecundity0.87767034
66MP0006072_abnormal_retinal_apoptosis0.87043664
67MP0009672_abnormal_birth_weight0.85455466
68MP0010030_abnormal_orbit_morphology0.83612798
69MP0002233_abnormal_nose_morphology0.83344675
70MP0005084_abnormal_gallbladder_morpholo0.83179247
71MP0002160_abnormal_reproductive_system0.82037023
72MP0002557_abnormal_social/conspecific_i0.81164114
73MP0001697_abnormal_embryo_size0.77857388
74MP0000534_abnormal_ureter_morphology0.76575952
75MP0003195_calcinosis0.76334541
76MP0010386_abnormal_urinary_bladder0.75518299
77MP0000647_abnormal_sebaceous_gland0.75216285
78MP0005253_abnormal_eye_physiology0.74736655
79MP0008873_increased_physiological_sensi0.73295200
80MP0001970_abnormal_pain_threshold0.73285899
81MP0005380_embryogenesis_phenotype0.72802262
82MP0001672_abnormal_embryogenesis/_devel0.72802262
83MP0005645_abnormal_hypothalamus_physiol0.72513005
84MP0000678_abnormal_parathyroid_gland0.72378456
85MP0002111_abnormal_tail_morphology0.72297570
86MP0003755_abnormal_palate_morphology0.69276430
87MP0002080_prenatal_lethality0.68676050
88MP0002254_reproductive_system_inflammat0.68613245
89MP0003186_abnormal_redox_activity0.68380553
90MP0004142_abnormal_muscle_tone0.66942584
91MP0008877_abnormal_DNA_methylation0.66253756
92MP0002102_abnormal_ear_morphology0.66047402
93MP0002272_abnormal_nervous_system0.64282125
94MP0001963_abnormal_hearing_physiology0.64121403
95MP0003938_abnormal_ear_development0.61858701
96MP0003283_abnormal_digestive_organ0.61679508
97MP0003315_abnormal_perineum_morphology0.61290666
98MP0009703_decreased_birth_body0.61214469
99MP0005248_abnormal_Harderian_gland0.60456937
100MP0000631_abnormal_neuroendocrine_gland0.60445413

Predicted human phenotypes

RankGene SetZ-score
1Acute encephalopathy (HP:0006846)5.32624754
2Acute necrotizing encephalopathy (HP:0006965)4.84667212
3Ulnar claw (HP:0001178)4.63689119
4Abnormal mitochondria in muscle tissue (HP:0008316)4.38397387
5Progressive macrocephaly (HP:0004481)3.63791005
6Hyperglycinemia (HP:0002154)3.44952672
7Cerebral edema (HP:0002181)3.40893331
8Pancreatic islet-cell hyperplasia (HP:0004510)3.32930776
9Mitochondrial inheritance (HP:0001427)3.31513393
10Abnormality of cells of the erythroid lineage (HP:0012130)3.27462484
11Limb hypertonia (HP:0002509)3.18159822
12Abnormality of macular pigmentation (HP:0008002)3.14577870
13Increased CSF lactate (HP:0002490)3.06930454
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03852921
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03852921
16Segmental peripheral demyelination/remyelination (HP:0003481)2.96405627
17Abnormal number of erythroid precursors (HP:0012131)2.82495524
18Abnormality of the labia minora (HP:0012880)2.77986269
19Generalized aminoaciduria (HP:0002909)2.74174859
20Macrocytic anemia (HP:0001972)2.70609826
21Unilateral renal agenesis (HP:0000122)2.65804161
22Hepatic necrosis (HP:0002605)2.64993373
23Reticulocytopenia (HP:0001896)2.61234117
24Hypomagnesemia (HP:0002917)2.55026155
253-Methylglutaconic aciduria (HP:0003535)2.53510771
26Aplasia/hypoplasia of the uterus (HP:0008684)2.49214115
27Stenosis of the external auditory canal (HP:0000402)2.48969586
28Increased serum lactate (HP:0002151)2.48871082
29Tetany (HP:0001281)2.48661883
30Hepatocellular necrosis (HP:0001404)2.47889729
31Hypoplasia of the uterus (HP:0000013)2.43811894
32Lactic acidosis (HP:0003128)2.42991673
33Bilateral microphthalmos (HP:0007633)2.42722736
34Entropion (HP:0000621)2.33625083
35Large for gestational age (HP:0001520)2.32363436
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31179788
37Abnormality of magnesium homeostasis (HP:0004921)2.30740724
38Muscular hypotonia of the trunk (HP:0008936)2.30738505
39Abnormality of the aortic arch (HP:0012303)2.27356417
40Cleft eyelid (HP:0000625)2.19831701
41Rough bone trabeculation (HP:0100670)2.18903297
42Leukodystrophy (HP:0002415)2.17054387
43Myelomeningocele (HP:0002475)2.17023700
44Shoulder girdle muscle weakness (HP:0003547)2.16143822
45Hyperglycinuria (HP:0003108)2.14459961
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11958515
47Poor head control (HP:0002421)2.10215725
48Atonic seizures (HP:0010819)2.07272190
49Abnormality of endocrine pancreas physiology (HP:0012093)2.05802906
50Abnormality of the pancreatic islet cells (HP:0006476)2.05802906
51Absent septum pellucidum (HP:0001331)2.03028687
52Abnormal lung lobation (HP:0002101)2.02657423
53Hyperinsulinemic hypoglycemia (HP:0000825)2.02215571
54Respiratory failure (HP:0002878)2.00570984
55Exercise intolerance (HP:0003546)1.99538162
56Upper limb muscle weakness (HP:0003484)1.99469742
57Truncus arteriosus (HP:0001660)1.99092832
58Lethargy (HP:0001254)1.97223702
59Increased hepatocellular lipid droplets (HP:0006565)1.96949142
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96085760
61Increased serum pyruvate (HP:0003542)1.94401534
62Abnormality of serum amino acid levels (HP:0003112)1.92734060
63Abnormality of the musculature of the hand (HP:0001421)1.92032619
64Prominent metopic ridge (HP:0005487)1.91905072
65Mitral stenosis (HP:0001718)1.91383012
66Hypoglycemic coma (HP:0001325)1.90923845
67Abnormality of serine family amino acid metabolism (HP:0010894)1.90630644
68Abnormality of glycine metabolism (HP:0010895)1.90630644
69Pallor (HP:0000980)1.90256788
70Congenital malformation of the right heart (HP:0011723)1.89775630
71Double outlet right ventricle (HP:0001719)1.89775630
72Birth length less than 3rd percentile (HP:0003561)1.89459659
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89393312
74Abnormality of alanine metabolism (HP:0010916)1.89393312
75Hyperalaninemia (HP:0003348)1.89393312
76Volvulus (HP:0002580)1.88368901
77Sclerocornea (HP:0000647)1.87851337
78Colon cancer (HP:0003003)1.86013105
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85387784
80Polydipsia (HP:0001959)1.85379838
81Abnormal drinking behavior (HP:0030082)1.85379838
82Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84522496
83Pelvic girdle muscle weakness (HP:0003749)1.83245186
84Hyperthyroidism (HP:0000836)1.81586728
85Abnormal respiratory epithelium morphology (HP:0012253)1.79975982
86Abnormal respiratory motile cilium morphology (HP:0005938)1.79975982
87Trismus (HP:0000211)1.77637608
88Multiple enchondromatosis (HP:0005701)1.77586223
89Abnormality of glycolysis (HP:0004366)1.77413892
90Pendular nystagmus (HP:0012043)1.75871560
91Sensory axonal neuropathy (HP:0003390)1.75531940
92Optic disc pallor (HP:0000543)1.75483150
93Congenital, generalized hypertrichosis (HP:0004540)1.74581399
94Overlapping toe (HP:0001845)1.72136379
95Degeneration of anterior horn cells (HP:0002398)1.71932769
96Abnormality of the anterior horn cell (HP:0006802)1.71932769
97Blindness (HP:0000618)1.69034964
98Testicular atrophy (HP:0000029)1.67594704
99Cortical visual impairment (HP:0100704)1.64913038
100Split foot (HP:0001839)1.62312742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.23813221
2TLK13.87571915
3TSSK63.33387780
4BUB13.20378564
5VRK12.66949055
6WNK42.65316008
7BMPR1B2.64940907
8CDC72.60558415
9CAMK1D2.48870567
10ARAF2.46326597
11ACVR1B2.07988784
12PLK42.07896232
13MAP3K92.03161792
14NEK12.02405428
15MKNK21.91370897
16TAF11.90485620
17BCKDK1.86382125
18STK391.84619609
19MST41.67011106
20EIF2AK11.65022441
21SRPK11.63355635
22PLK31.62383493
23CAMK1G1.60925328
24TTK1.53397723
25VRK21.50779708
26DYRK31.42695525
27AURKA1.42627967
28CSNK1G21.37455173
29MKNK11.31024626
30DYRK21.21102874
31RPS6KA51.18081543
32NUAK11.14194240
33ATR1.12062875
34PINK11.10185920
35AURKB1.06104974
36PDK20.99998653
37WNK30.99598145
38PASK0.99394241
39CSNK1G30.97239729
40MAP4K20.97234152
41PLK10.93844432
42OXSR10.93620023
43CSNK1G10.89531697
44EPHA40.88815042
45INSRR0.84956089
46CSNK1E0.83120388
47CHEK10.81567133
48CAMKK20.80391453
49TNIK0.77342019
50TGFBR10.77202864
51PBK0.76045054
52ERBB40.75706087
53LATS20.75403006
54DAPK30.71822124
55BCR0.70958199
56TRIM280.70667215
57PRKCG0.68928700
58STK40.65241033
59CDK70.64589852
60CAMK2A0.62779797
61PLK20.60441270
62ABL20.60429757
63ALK0.59959087
64PRKACB0.59140295
65CSNK2A20.59003410
66MOS0.55702960
67CSNK1A1L0.54341671
68PRKCE0.54234598
69MAP2K10.53458581
70BRD40.49604621
71GRK10.49374295
72BRAF0.49204752
73ATM0.48972497
74RPS6KA40.48588914
75EPHB20.46819259
76WNK10.46627430
77CASK0.45601344
78ILK0.42962277
79CDK40.42317048
80PAK10.41665974
81CDK20.41660434
82RAF10.40367748
83CDK180.40151433
84NME20.40049510
85CSNK1D0.40039822
86CDK150.39701224
87CAMK2D0.39141771
88CDK11A0.37997031
89FGFR10.37723588
90PRKCH0.36773123
91CHEK20.36121372
92CAMK2G0.35634101
93PRKDC0.35183238
94UHMK10.34598229
95CDK10.33008400
96PRKCD0.32643917
97ERBB20.32352475
98CAMK2B0.32282094
99TIE10.32199228
100PRKACG0.31648426

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.66937943
2Proteasome_Homo sapiens_hsa030503.47424880
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35046001
4Oxidative phosphorylation_Homo sapiens_hsa001903.31426403
5Parkinsons disease_Homo sapiens_hsa050122.95488364
6RNA polymerase_Homo sapiens_hsa030202.85194852
7Systemic lupus erythematosus_Homo sapiens_hsa053222.82962776
8Basal transcription factors_Homo sapiens_hsa030222.51853433
9Huntingtons disease_Homo sapiens_hsa050162.42409357
10Spliceosome_Homo sapiens_hsa030402.31216867
11DNA replication_Homo sapiens_hsa030302.29350947
12Alcoholism_Homo sapiens_hsa050342.10708976
13Alzheimers disease_Homo sapiens_hsa050102.07159481
14Sulfur relay system_Homo sapiens_hsa041222.04997277
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03397968
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00468051
17Mismatch repair_Homo sapiens_hsa034301.98880394
18RNA transport_Homo sapiens_hsa030131.95088134
19RNA degradation_Homo sapiens_hsa030181.89882768
20Homologous recombination_Homo sapiens_hsa034401.85458050
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83101679
22Protein export_Homo sapiens_hsa030601.76746642
23Selenocompound metabolism_Homo sapiens_hsa004501.65641952
24Pyrimidine metabolism_Homo sapiens_hsa002401.57778241
25One carbon pool by folate_Homo sapiens_hsa006701.54701191
26Sulfur metabolism_Homo sapiens_hsa009201.54564380
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52471744
28Fanconi anemia pathway_Homo sapiens_hsa034601.51157343
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.50215890
30Vitamin B6 metabolism_Homo sapiens_hsa007501.49298748
31Cardiac muscle contraction_Homo sapiens_hsa042601.40085592
32mRNA surveillance pathway_Homo sapiens_hsa030151.39352054
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.35860763
34Base excision repair_Homo sapiens_hsa034101.34472718
35Nucleotide excision repair_Homo sapiens_hsa034201.32350555
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29830481
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19259593
38Nitrogen metabolism_Homo sapiens_hsa009101.16953209
39Glutathione metabolism_Homo sapiens_hsa004801.15890889
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15844743
41Arginine biosynthesis_Homo sapiens_hsa002201.14774163
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09154408
43Fatty acid biosynthesis_Homo sapiens_hsa000611.07221746
44Non-homologous end-joining_Homo sapiens_hsa034501.03090456
45Purine metabolism_Homo sapiens_hsa002301.02062633
46Cell cycle_Homo sapiens_hsa041100.96202426
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94237428
48Viral carcinogenesis_Homo sapiens_hsa052030.93362404
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93287127
50Tyrosine metabolism_Homo sapiens_hsa003500.89852676
51Arginine and proline metabolism_Homo sapiens_hsa003300.87568160
52Folate biosynthesis_Homo sapiens_hsa007900.86974632
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82161178
54Propanoate metabolism_Homo sapiens_hsa006400.79116024
55Metabolic pathways_Homo sapiens_hsa011000.76633352
56Pyruvate metabolism_Homo sapiens_hsa006200.75914332
57Linoleic acid metabolism_Homo sapiens_hsa005910.72426182
58Phototransduction_Homo sapiens_hsa047440.72144395
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70194832
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69508483
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66069185
62Taste transduction_Homo sapiens_hsa047420.65894118
63Steroid biosynthesis_Homo sapiens_hsa001000.65286582
64Nicotine addiction_Homo sapiens_hsa050330.64199502
65Fat digestion and absorption_Homo sapiens_hsa049750.63126411
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.62241797
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.62031824
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60159610
69Fatty acid elongation_Homo sapiens_hsa000620.59946929
70Biosynthesis of amino acids_Homo sapiens_hsa012300.58638115
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57711778
72Carbon metabolism_Homo sapiens_hsa012000.56085508
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49997543
74Peroxisome_Homo sapiens_hsa041460.47857230
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45739898
76Olfactory transduction_Homo sapiens_hsa047400.44918341
77Arachidonic acid metabolism_Homo sapiens_hsa005900.42983674
78Serotonergic synapse_Homo sapiens_hsa047260.41499836
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38711040
80Tryptophan metabolism_Homo sapiens_hsa003800.37938264
81beta-Alanine metabolism_Homo sapiens_hsa004100.36876855
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36817400
83Ether lipid metabolism_Homo sapiens_hsa005650.32646014
84TGF-beta signaling pathway_Homo sapiens_hsa043500.32148488
85Butanoate metabolism_Homo sapiens_hsa006500.28880441
86Vitamin digestion and absorption_Homo sapiens_hsa049770.27732475
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27164371
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26872474
89Oocyte meiosis_Homo sapiens_hsa041140.24684835
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23137634
91Epstein-Barr virus infection_Homo sapiens_hsa051690.21550826
92Tight junction_Homo sapiens_hsa045300.20718072
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18756460
94Caffeine metabolism_Homo sapiens_hsa002320.16271141
95Renin-angiotensin system_Homo sapiens_hsa046140.15916650
96Chemical carcinogenesis_Homo sapiens_hsa052040.13246653
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12628829
98Phenylalanine metabolism_Homo sapiens_hsa003600.12034197
99Basal cell carcinoma_Homo sapiens_hsa052170.11255720
100Fatty acid metabolism_Homo sapiens_hsa012120.10408370

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