SETP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.34076650
2CENP-A containing nucleosome assembly (GO:0034080)5.30580600
3establishment of integrated proviral latency (GO:0075713)5.21274166
4regulation of translational termination (GO:0006449)4.75931429
5water-soluble vitamin biosynthetic process (GO:0042364)4.75813058
6DNA strand elongation involved in DNA replication (GO:0006271)4.58892093
7histone exchange (GO:0043486)4.40609277
8DNA strand elongation (GO:0022616)4.37733646
9L-serine metabolic process (GO:0006563)4.27250799
10DNA double-strand break processing (GO:0000729)4.25775746
11DNA damage response, detection of DNA damage (GO:0042769)4.23627469
12IMP biosynthetic process (GO:0006188)4.23567078
13DNA ligation (GO:0006266)4.18883045
14establishment of viral latency (GO:0019043)4.11769973
15DNA replication-independent nucleosome assembly (GO:0006336)3.95624749
16DNA replication-independent nucleosome organization (GO:0034724)3.95624749
17negative regulation of DNA-dependent DNA replication (GO:2000104)3.87690970
18IMP metabolic process (GO:0046040)3.84738707
19positive regulation of male gonad development (GO:2000020)3.84344705
20mitotic metaphase plate congression (GO:0007080)3.83183229
21cullin deneddylation (GO:0010388)3.83085671
22negative regulation of mitotic sister chromatid separation (GO:2000816)3.81342339
23negative regulation of sister chromatid segregation (GO:0033046)3.81342339
24negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.81342339
25negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.81342339
26negative regulation of mitotic sister chromatid segregation (GO:0033048)3.81342339
27telomere maintenance via semi-conservative replication (GO:0032201)3.76985513
28negative regulation of chromosome segregation (GO:0051985)3.75414358
29protein localization to kinetochore (GO:0034501)3.75060706
30double-strand break repair via nonhomologous end joining (GO:0006303)3.73534631
31non-recombinational repair (GO:0000726)3.73534631
32replication fork processing (GO:0031297)3.65216987
33protein deneddylation (GO:0000338)3.65012203
34negative regulation of DNA recombination (GO:0045910)3.64534120
35spindle checkpoint (GO:0031577)3.63244061
36ribosome assembly (GO:0042255)3.62812034
37DNA replication-dependent nucleosome organization (GO:0034723)3.60601179
38DNA replication-dependent nucleosome assembly (GO:0006335)3.60601179
39mitotic spindle checkpoint (GO:0071174)3.58749902
40DNA replication checkpoint (GO:0000076)3.56817141
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51016624
42proteasome assembly (GO:0043248)3.50824823
43DNA catabolic process, exonucleolytic (GO:0000738)3.46022711
44telomere maintenance via recombination (GO:0000722)3.42870830
45purine nucleobase biosynthetic process (GO:0009113)3.41209245
46metaphase plate congression (GO:0051310)3.41202537
47mitotic spindle assembly checkpoint (GO:0007094)3.40400758
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.40061090
49regulation of mitotic spindle checkpoint (GO:1903504)3.39594234
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.39594234
51regulation of mitotic metaphase/anaphase transition (GO:0030071)3.38664392
52regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.38664392
53mitotic recombination (GO:0006312)3.37894860
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37257503
55mitotic sister chromatid segregation (GO:0000070)3.36438844
56spindle assembly checkpoint (GO:0071173)3.34811255
57negative regulation of mitosis (GO:0045839)3.34676347
58histone H2A acetylation (GO:0043968)3.32159321
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.31912149
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31912149
61regulation of mitotic sister chromatid separation (GO:0010965)3.28884169
62regulation of mitotic sister chromatid segregation (GO:0033047)3.28884169
63regulation of sister chromatid segregation (GO:0033045)3.28884169
64response to pheromone (GO:0019236)3.28745137
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28620479
66DNA unwinding involved in DNA replication (GO:0006268)3.28619590
67DNA replication initiation (GO:0006270)3.26728599
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25888424
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24402958
70regulation of chromosome segregation (GO:0051983)3.22377048
71rRNA modification (GO:0000154)3.22104169
72tRNA methylation (GO:0030488)3.20852078
73nucleobase biosynthetic process (GO:0046112)3.18731835
74regulation of centriole replication (GO:0046599)3.17790910
75histone mRNA metabolic process (GO:0008334)3.17620773
76negative regulation of ligase activity (GO:0051352)3.16371841
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16371841
78DNA strand renaturation (GO:0000733)3.15361628
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14634246
80pseudouridine synthesis (GO:0001522)3.14413356
81regulation of helicase activity (GO:0051095)3.12427843
82regulation of male gonad development (GO:2000018)3.12078454
83telomere maintenance via telomere lengthening (GO:0010833)3.09121989
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08932142
85cell fate commitment involved in formation of primary germ layer (GO:0060795)3.08904531
86chromatin assembly or disassembly (GO:0006333)3.07678576
87telomere maintenance via telomerase (GO:0007004)3.06612587
88sister chromatid segregation (GO:0000819)3.05009070
89attachment of spindle microtubules to kinetochore (GO:0008608)3.02881377
90establishment of chromosome localization (GO:0051303)3.00064910
91RNA-dependent DNA replication (GO:0006278)2.99966284
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99133091
93recombinational repair (GO:0000725)2.99042107
94negative regulation of nuclear division (GO:0051784)2.98312665
95double-strand break repair via homologous recombination (GO:0000724)2.97660836
96DNA-dependent DNA replication (GO:0006261)2.97444063
97protein localization to chromosome, centromeric region (GO:0071459)2.96678985
98telomere maintenance (GO:0000723)2.94856374
99ATP-dependent chromatin remodeling (GO:0043044)2.94238226
100telomere organization (GO:0032200)2.93191718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.08770327
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.60077550
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.39078805
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.14146819
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.62699759
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.61526103
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.47989937
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.09998336
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.00910383
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92864911
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.88562455
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67238585
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.63092562
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56879109
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51884220
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51715605
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51349576
18ELK1_19687146_ChIP-ChIP_HELA_Human2.39874817
19VDR_23849224_ChIP-Seq_CD4+_Human2.39251142
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36194713
21AR_21909140_ChIP-Seq_LNCAP_Human2.32675941
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22332133
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15919873
24FOXP3_21729870_ChIP-Seq_TREG_Human2.14048315
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09638271
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08881943
27POU5F1_16153702_ChIP-ChIP_HESCs_Human2.08050224
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06213922
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99436884
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94760952
31IRF1_19129219_ChIP-ChIP_H3396_Human1.91747956
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91050527
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89132436
34TTF2_22483619_ChIP-Seq_HELA_Human1.86170705
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.86138105
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83052769
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81954579
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.81053316
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78970365
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75361759
41DCP1A_22483619_ChIP-Seq_HELA_Human1.74411499
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69833002
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69680464
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.69477795
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68855784
46EWS_26573619_Chip-Seq_HEK293_Human1.66705209
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58639240
48GABP_19822575_ChIP-Seq_HepG2_Human1.58416382
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55336491
50MYC_18940864_ChIP-ChIP_HL60_Human1.55057469
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50671792
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.46373828
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46303622
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.44391833
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.43931720
56XRN2_22483619_ChIP-Seq_HELA_Human1.42771977
57ZNF274_21170338_ChIP-Seq_K562_Hela1.34149216
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26929733
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24796662
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23184695
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21667865
62VDR_22108803_ChIP-Seq_LS180_Human1.21426044
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.19691581
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.17173863
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15398725
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09651129
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08643746
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07472808
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07319999
70IGF1R_20145208_ChIP-Seq_DFB_Human1.06285704
71KDM5A_27292631_Chip-Seq_BREAST_Human1.02457682
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97438200
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97199431
74FUS_26573619_Chip-Seq_HEK293_Human0.95311948
75NOTCH1_21737748_ChIP-Seq_TLL_Human0.94717426
76ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93790020
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90940001
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90183180
79ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89032292
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86525373
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85965530
82TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85291197
83NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84262440
84TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84162828
85P300_19829295_ChIP-Seq_ESCs_Human0.82734534
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81426783
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80558010
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.79795234
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.79122940
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78366601
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76921433
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76413145
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72875248
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72364705
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71453625
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71369421
97TP53_22573176_ChIP-Seq_HFKS_Human0.70691622
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.70130290
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.70042941
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69503641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.19979878
2MP0010094_abnormal_chromosome_stability5.08090286
3MP0008058_abnormal_DNA_repair4.51350675
4MP0004957_abnormal_blastocyst_morpholog4.26220983
5MP0003111_abnormal_nucleus_morphology4.14982073
6MP0003077_abnormal_cell_cycle3.10287247
7MP0008932_abnormal_embryonic_tissue2.87454543
8MP0001529_abnormal_vocalization2.70351420
9MP0008007_abnormal_cellular_replicative2.51589104
10MP0002102_abnormal_ear_morphology2.50502405
11MP0008057_abnormal_DNA_replication2.43757909
12MP0008877_abnormal_DNA_methylation2.39595734
13MP0003718_maternal_effect2.37879744
14MP0006035_abnormal_mitochondrial_morpho2.37791478
15MP0003890_abnormal_embryonic-extraembry2.15369246
16MP0003786_premature_aging2.09293781
17MP0009697_abnormal_copulation2.07095543
18MP0003941_abnormal_skin_development2.06733372
19MP0006292_abnormal_olfactory_placode1.98987576
20MP0001293_anophthalmia1.87097206
21MP0002751_abnormal_autonomic_nervous1.80642722
22MP0010352_gastrointestinal_tract_polyps1.79204691
23MP0008789_abnormal_olfactory_epithelium1.76977592
24MP0000566_synostosis1.68330249
25MP0001730_embryonic_growth_arrest1.63233027
26MP0003119_abnormal_digestive_system1.60766379
27MP0000350_abnormal_cell_proliferation1.57996037
28MP0009672_abnormal_birth_weight1.52583567
29MP0003121_genomic_imprinting1.45689669
30MP0003123_paternal_imprinting1.44413064
31MP0005394_taste/olfaction_phenotype1.43979891
32MP0005499_abnormal_olfactory_system1.43979891
33MP0001672_abnormal_embryogenesis/_devel1.39508807
34MP0005380_embryogenesis_phenotype1.39508807
35MP0001727_abnormal_embryo_implantation1.37935291
36MP0002085_abnormal_embryonic_tissue1.37309573
37MP0006072_abnormal_retinal_apoptosis1.37215703
38MP0000490_abnormal_crypts_of1.36894386
39MP0003806_abnormal_nucleotide_metabolis1.35676098
40MP0000647_abnormal_sebaceous_gland1.35628750
41MP0001697_abnormal_embryo_size1.34480044
42MP0000358_abnormal_cell_content/1.32419880
43MP0006036_abnormal_mitochondrial_physio1.30289075
44MP0002254_reproductive_system_inflammat1.30225670
45MP0002736_abnormal_nociception_after1.25785622
46MP0001188_hyperpigmentation1.20979962
47MP0003984_embryonic_growth_retardation1.17141302
48MP0003567_abnormal_fetal_cardiomyocyte1.16525332
49MP0002080_prenatal_lethality1.16225773
50MP0004742_abnormal_vestibular_system1.16070578
51MP0002088_abnormal_embryonic_growth/wei1.15465968
52MP0002084_abnormal_developmental_patter1.14215597
53MP0003122_maternal_imprinting1.13895810
54MP0010307_abnormal_tumor_latency1.12535227
55MP0002938_white_spotting1.11302511
56MP0004197_abnormal_fetal_growth/weight/1.09958170
57MP0005187_abnormal_penis_morphology1.06714711
58MP0002210_abnormal_sex_determination1.03625787
59MP0002396_abnormal_hematopoietic_system1.03615605
60MP0000313_abnormal_cell_death1.02036298
61MP0001485_abnormal_pinna_reflex0.99968541
62MP0001984_abnormal_olfaction0.97307187
63MP0004782_abnormal_surfactant_physiolog0.97175431
64MP0003937_abnormal_limbs/digits/tail_de0.96732173
65MP0001346_abnormal_lacrimal_gland0.94047141
66MP0001286_abnormal_eye_development0.91028970
67MP0001929_abnormal_gametogenesis0.88995979
68MP0002086_abnormal_extraembryonic_tissu0.85552241
69MP0003880_abnormal_central_pattern0.85295893
70MP0003787_abnormal_imprinting0.84478344
71MP0009703_decreased_birth_body0.84159304
72MP0001145_abnormal_male_reproductive0.82579739
73MP0000653_abnormal_sex_gland0.82344817
74MP0002111_abnormal_tail_morphology0.79945547
75MP0010030_abnormal_orbit_morphology0.79690959
76MP0005253_abnormal_eye_physiology0.79177632
77MP0002697_abnormal_eye_size0.76080505
78MP0000383_abnormal_hair_follicle0.75042406
79MP0002019_abnormal_tumor_incidence0.74166343
80MP0003861_abnormal_nervous_system0.72041901
81MP0000537_abnormal_urethra_morphology0.72009252
82MP0004147_increased_porphyrin_level0.69585034
83MP0003315_abnormal_perineum_morphology0.69552459
84MP0008873_increased_physiological_sensi0.69180151
85MP0000427_abnormal_hair_cycle0.68607289
86MP0003936_abnormal_reproductive_system0.66786791
87MP0005391_vision/eye_phenotype0.65941028
88MP0001119_abnormal_female_reproductive0.64651870
89MP0008770_decreased_survivor_rate0.63075414
90MP0001177_atelectasis0.61565109
91MP0001968_abnormal_touch/_nociception0.61213715
92MP0003942_abnormal_urinary_system0.61073098
93MP0005395_other_phenotype0.60912023
94MP0002233_abnormal_nose_morphology0.59908286
95MP0000579_abnormal_nail_morphology0.58978819
96MP0002796_impaired_skin_barrier0.58943392
97MP0001299_abnormal_eye_distance/0.58597925
98MP0002160_abnormal_reproductive_system0.58144451
99MP0005384_cellular_phenotype0.57583556
100MP0000631_abnormal_neuroendocrine_gland0.57398694

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.49160211
2Methylmalonic acidemia (HP:0002912)4.14551619
3Colon cancer (HP:0003003)3.94319215
4Hyperglycinemia (HP:0002154)3.52730923
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37885021
6Methylmalonic aciduria (HP:0012120)3.36941417
7Ependymoma (HP:0002888)3.34687825
8Abnormality of serum amino acid levels (HP:0003112)3.32029088
9Abnormal lung lobation (HP:0002101)3.24411205
10Homocystinuria (HP:0002156)3.23903823
11Abnormality of homocysteine metabolism (HP:0010919)3.23903823
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14267227
13Abnormality of alanine metabolism (HP:0010916)3.14267227
14Hyperalaninemia (HP:0003348)3.14267227
15Abnormality of methionine metabolism (HP:0010901)3.13588594
16Nephroblastoma (Wilms tumor) (HP:0002667)3.05394106
17Meckel diverticulum (HP:0002245)3.04002429
18Abnormality of the ileum (HP:0001549)3.01733361
19Abnormality of chromosome stability (HP:0003220)2.98268854
20Embryonal renal neoplasm (HP:0011794)2.87963636
21Abnormal hair whorl (HP:0010721)2.87826020
22Chromsome breakage (HP:0040012)2.87800695
23Birth length less than 3rd percentile (HP:0003561)2.82383213
24Abnormality of the preputium (HP:0100587)2.80714112
25Agnosia (HP:0010524)2.71008382
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.61745806
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60559396
28Ectopic kidney (HP:0000086)2.59988968
29Acute necrotizing encephalopathy (HP:0006965)2.59758799
30Abnormality of the vitamin B12 metabolism (HP:0004341)2.58750092
31Abnormality of serine family amino acid metabolism (HP:0010894)2.52550498
32Abnormality of glycine metabolism (HP:0010895)2.52550498
33Acute encephalopathy (HP:0006846)2.49403687
34Pancreatic islet-cell hyperplasia (HP:0004510)2.48577317
35Rhabdomyosarcoma (HP:0002859)2.47032004
36Small intestinal stenosis (HP:0012848)2.41405717
37Duodenal stenosis (HP:0100867)2.41405717
38Increased CSF lactate (HP:0002490)2.39969698
39Congenital, generalized hypertrichosis (HP:0004540)2.39144325
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.33857004
41Glioma (HP:0009733)2.33493027
42Abnormality of vitamin B metabolism (HP:0004340)2.33448854
43Abnormality of the duodenum (HP:0002246)2.30542225
44Septo-optic dysplasia (HP:0100842)2.29169757
45Increased hepatocellular lipid droplets (HP:0006565)2.27778363
46Cerebral hypomyelination (HP:0006808)2.24887842
47True hermaphroditism (HP:0010459)2.23902310
48Horseshoe kidney (HP:0000085)2.19504532
49Megaloblastic anemia (HP:0001889)2.18680573
50Astrocytoma (HP:0009592)2.17992486
51Abnormality of the astrocytes (HP:0100707)2.17992486
52Progressive macrocephaly (HP:0004481)2.16061851
53Hyperglycinuria (HP:0003108)2.16043199
54Medulloblastoma (HP:0002885)2.14535007
55Nausea (HP:0002018)2.14506075
56Sloping forehead (HP:0000340)2.12471714
57Adrenal hypoplasia (HP:0000835)2.07801093
58Abnormality of glycolysis (HP:0004366)2.07350654
59Breast aplasia (HP:0100783)2.06920859
60Triphalangeal thumb (HP:0001199)2.04837833
61Pendular nystagmus (HP:0012043)2.03731185
62Hypothermia (HP:0002045)2.00532094
63Mitochondrial inheritance (HP:0001427)2.00443411
64Abnormal mitochondria in muscle tissue (HP:0008316)2.00364967
65Increased serum lactate (HP:0002151)2.00254749
66Lipid accumulation in hepatocytes (HP:0006561)1.99623234
67Hypoplastic pelvis (HP:0008839)1.99525939
68Aplasia involving forearm bones (HP:0009822)1.99157504
69Absent forearm bone (HP:0003953)1.99157504
70Increased serum pyruvate (HP:0003542)1.99027678
71Patellar aplasia (HP:0006443)1.97678757
72Cerebral edema (HP:0002181)1.97286887
73Limb hypertonia (HP:0002509)1.94502298
74Generalized aminoaciduria (HP:0002909)1.93779776
75Absent radius (HP:0003974)1.91086676
76Neoplasm of the colon (HP:0100273)1.90542735
77Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88218401
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88218401
79Hypoplasia of the pons (HP:0012110)1.85036426
80Aplasia/Hypoplasia of the breasts (HP:0010311)1.84696586
813-Methylglutaconic aciduria (HP:0003535)1.84061659
82Aplasia/Hypoplasia of the patella (HP:0006498)1.82607501
83Neoplasm of the pancreas (HP:0002894)1.82374185
84Myelodysplasia (HP:0002863)1.82243108
85Absent septum pellucidum (HP:0001331)1.81808408
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80978542
87Ovarian neoplasm (HP:0100615)1.80359423
88Lactic acidosis (HP:0003128)1.79922639
89Small hand (HP:0200055)1.79710175
90Clubbing of toes (HP:0100760)1.78529848
91Prostate neoplasm (HP:0100787)1.78125306
92Overlapping toe (HP:0001845)1.77556591
93Renal Fanconi syndrome (HP:0001994)1.76095038
94Primary amenorrhea (HP:0000786)1.75319921
95Inability to walk (HP:0002540)1.74734397
96Hepatocellular necrosis (HP:0001404)1.74588282
97Bifid tongue (HP:0010297)1.74336975
98Secondary amenorrhea (HP:0000869)1.72800373
99Micronodular cirrhosis (HP:0001413)1.72269463
100Hepatic necrosis (HP:0002605)1.72186012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.09747898
2VRK24.08714068
3ZAK3.94200780
4BUB13.69978328
5VRK13.18198473
6TNIK2.78066153
7PLK32.67308940
8MKNK22.66277805
9WNK32.61646977
10TLK12.54260227
11CDC72.51394959
12MKNK12.50239224
13TAF12.42987651
14TTK2.39383159
15SRPK12.18991773
16PBK2.17250520
17NUAK12.06333094
18PDK22.04314143
19NEK12.02651802
20EIF2AK31.92151947
21BMPR1B1.89565287
22MST41.79880927
23STK161.78075270
24PLK41.75537614
25PLK11.62267438
26WEE11.51997322
27EIF2AK11.46003115
28CCNB11.29305153
29CSNK1G11.22689318
30CSNK1G31.22167929
31CHEK21.18415076
32CSNK1G21.17445360
33ATR1.16139499
34TRIM281.13789240
35ACVR1B1.13362334
36TGFBR11.12633340
37BRSK21.10782467
38SMG11.06641074
39OXSR11.04620585
40ERBB30.96608581
41NLK0.96206458
42NME10.95556376
43BCKDK0.93856949
44PASK0.92270015
45NEK20.89197994
46STK390.87831902
47AURKB0.85908614
48MELK0.84616084
49MAP3K120.83498519
50DYRK20.81192349
51CSNK1A1L0.80036618
52PAK40.77701234
53BCR0.76070855
54EIF2AK20.75900597
55ATM0.75556870
56ALK0.74848788
57AURKA0.73203628
58STK40.72803951
59TAOK30.71308206
60STK30.64468205
61CDK70.59137560
62CHEK10.58843526
63PNCK0.58313471
64DAPK10.58194964
65ADRBK20.55512632
66DAPK30.54289077
67RPS6KA50.54092437
68RPS6KA40.53171034
69CSNK1E0.52673535
70GRK10.49325027
71NME20.49178640
72CSNK2A10.48335550
73DYRK30.47991346
74CLK10.43771288
75PRKCE0.43334334
76CDK60.42696166
77FGFR20.42068759
78BRSK10.41229154
79CSNK2A20.39814933
80STK38L0.37882983
81CDK20.35763950
82TEC0.35749898
83BRAF0.34872847
84CDK90.34347909
85CAMK1D0.32402480
86CSNK1A10.30025538
87CDK10.29507451
88FGFR10.27548790
89MAP3K80.24987952
90GSK3A0.22602588
91CDK180.21464485
92PIM10.20976111
93NEK90.19208369
94BRD40.18280999
95CDK150.18114518
96CSNK1D0.18008140
97PRKDC0.17177178
98CDK140.17031909
99CDK11A0.16036424
100PRKCG0.15266661

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.97894759
2Mismatch repair_Homo sapiens_hsa034303.91397459
3DNA replication_Homo sapiens_hsa030303.89167724
4Non-homologous end-joining_Homo sapiens_hsa034503.31724372
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96555221
6Homologous recombination_Homo sapiens_hsa034402.90414132
7Fanconi anemia pathway_Homo sapiens_hsa034602.68130992
8Spliceosome_Homo sapiens_hsa030402.55905733
9One carbon pool by folate_Homo sapiens_hsa006702.51244025
10RNA degradation_Homo sapiens_hsa030182.37742749
11Protein export_Homo sapiens_hsa030602.37134944
12RNA transport_Homo sapiens_hsa030132.34110409
13Systemic lupus erythematosus_Homo sapiens_hsa053222.32057646
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30857485
15Basal transcription factors_Homo sapiens_hsa030222.28490849
16Cell cycle_Homo sapiens_hsa041102.18485571
17Propanoate metabolism_Homo sapiens_hsa006402.13905970
18RNA polymerase_Homo sapiens_hsa030202.10759854
19Base excision repair_Homo sapiens_hsa034102.09024346
20Nucleotide excision repair_Homo sapiens_hsa034201.95530540
21Parkinsons disease_Homo sapiens_hsa050121.78838331
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78818741
23Steroid biosynthesis_Homo sapiens_hsa001001.68119599
24Oxidative phosphorylation_Homo sapiens_hsa001901.64396502
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63706475
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63614913
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.56023896
28Pyruvate metabolism_Homo sapiens_hsa006201.55827806
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52551546
30Pyrimidine metabolism_Homo sapiens_hsa002401.51292036
31Ribosome_Homo sapiens_hsa030101.42228134
32Alcoholism_Homo sapiens_hsa050341.41254502
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40570329
34Huntingtons disease_Homo sapiens_hsa050161.36865400
35Fatty acid elongation_Homo sapiens_hsa000621.28840269
36Viral carcinogenesis_Homo sapiens_hsa052031.18687309
37Selenocompound metabolism_Homo sapiens_hsa004501.16929006
38p53 signaling pathway_Homo sapiens_hsa041151.15296718
39Purine metabolism_Homo sapiens_hsa002301.10656668
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09213332
41Vitamin B6 metabolism_Homo sapiens_hsa007501.09137045
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02015592
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00075120
44mRNA surveillance pathway_Homo sapiens_hsa030150.99939571
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91524325
46Alzheimers disease_Homo sapiens_hsa050100.87795398
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84354125
48Oocyte meiosis_Homo sapiens_hsa041140.83098289
49Carbon metabolism_Homo sapiens_hsa012000.79056564
50Biosynthesis of amino acids_Homo sapiens_hsa012300.78674225
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77175761
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75019767
53Phototransduction_Homo sapiens_hsa047440.72605574
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71182877
55Vitamin digestion and absorption_Homo sapiens_hsa049770.63787954
56Glutathione metabolism_Homo sapiens_hsa004800.63377567
57Butanoate metabolism_Homo sapiens_hsa006500.56043321
58TGF-beta signaling pathway_Homo sapiens_hsa043500.53946329
59Sulfur metabolism_Homo sapiens_hsa009200.53379450
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50699214
61Epstein-Barr virus infection_Homo sapiens_hsa051690.50411250
62Sulfur relay system_Homo sapiens_hsa041220.49694476
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49089322
64Metabolic pathways_Homo sapiens_hsa011000.44204822
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.42832792
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42423937
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42271774
68Hippo signaling pathway_Homo sapiens_hsa043900.39673136
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39490767
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37193510
71Basal cell carcinoma_Homo sapiens_hsa052170.37035995
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35652167
73Peroxisome_Homo sapiens_hsa041460.35150543
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32927023
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31884718
76Wnt signaling pathway_Homo sapiens_hsa043100.30622128
77Hedgehog signaling pathway_Homo sapiens_hsa043400.29518792
78Thyroid cancer_Homo sapiens_hsa052160.29299600
79Folate biosynthesis_Homo sapiens_hsa007900.28721202
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28525666
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27753286
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27303477
83Galactose metabolism_Homo sapiens_hsa000520.27007199
84Caffeine metabolism_Homo sapiens_hsa002320.22380492
85Tight junction_Homo sapiens_hsa045300.20985916
86beta-Alanine metabolism_Homo sapiens_hsa004100.20729700
87Colorectal cancer_Homo sapiens_hsa052100.20575789
88Cardiac muscle contraction_Homo sapiens_hsa042600.19902417
89HTLV-I infection_Homo sapiens_hsa051660.17713129
90Legionellosis_Homo sapiens_hsa051340.16943372
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16293615
92Adherens junction_Homo sapiens_hsa045200.15486294
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13970771
94Arginine and proline metabolism_Homo sapiens_hsa003300.11369155
95Lysine degradation_Homo sapiens_hsa003100.10632067
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07131449
97Herpes simplex infection_Homo sapiens_hsa051680.07013963
98Nitrogen metabolism_Homo sapiens_hsa009100.05793680
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.04267541
100Tryptophan metabolism_Homo sapiens_hsa003800.03852909

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