SETP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1translational termination (GO:0006415)6.25015392
2viral transcription (GO:0019083)6.19758578
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.86124831
4ATP synthesis coupled proton transport (GO:0015986)5.72766811
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.72766811
6ribosomal small subunit assembly (GO:0000028)5.68201640
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.60922485
8ribosomal large subunit biogenesis (GO:0042273)5.40251632
9regulation of mitochondrial translation (GO:0070129)5.39477704
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.25917204
11cotranslational protein targeting to membrane (GO:0006613)5.20264864
12establishment of integrated proviral latency (GO:0075713)5.19610073
13protein targeting to ER (GO:0045047)5.15244385
14translational elongation (GO:0006414)5.12457803
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.95551867
16chromatin remodeling at centromere (GO:0031055)4.93088752
17cellular protein complex disassembly (GO:0043624)4.89154540
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.83878881
19translational initiation (GO:0006413)4.82011710
20protein localization to endoplasmic reticulum (GO:0070972)4.81505545
21primitive streak formation (GO:0090009)4.71345537
22CENP-A containing nucleosome assembly (GO:0034080)4.62387737
23viral life cycle (GO:0019058)4.55764346
24DNA damage response, detection of DNA damage (GO:0042769)4.33081380
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.28086784
26protein complex disassembly (GO:0043241)4.25320072
27organelle disassembly (GO:1903008)4.22401734
28macromolecular complex disassembly (GO:0032984)4.19346973
29positive regulation of gastrulation (GO:2000543)4.12586856
30ribosomal small subunit biogenesis (GO:0042274)3.95662321
31peptidyl-histidine modification (GO:0018202)3.90494534
32respiratory electron transport chain (GO:0022904)3.86204793
33establishment of viral latency (GO:0019043)3.85290164
34proteasome assembly (GO:0043248)3.82616429
35histone exchange (GO:0043486)3.80688605
36translation (GO:0006412)3.76931050
37maturation of SSU-rRNA (GO:0030490)3.74070944
38electron transport chain (GO:0022900)3.70537323
39sequestering of actin monomers (GO:0042989)3.69862833
40nuclear-transcribed mRNA catabolic process (GO:0000956)3.58551818
41DNA replication-independent nucleosome organization (GO:0034724)3.56347177
42DNA replication-independent nucleosome assembly (GO:0006336)3.56347177
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.50296240
44regulation of translation, ncRNA-mediated (GO:0045974)3.50296240
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.50296240
46DNA ligation (GO:0006266)3.42221913
47ribonucleoprotein complex biogenesis (GO:0022613)3.41535024
48ribonucleoprotein complex disassembly (GO:0032988)3.41099377
49generation of neurons (GO:0048699)3.40648661
50mRNA catabolic process (GO:0006402)3.39036974
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.36640949
52regulation of posttranscriptional gene silencing (GO:0060147)3.34517891
53regulation of gene silencing by miRNA (GO:0060964)3.34517891
54regulation of gene silencing by RNA (GO:0060966)3.34517891
55chaperone-mediated protein transport (GO:0072321)3.31489429
56protein targeting to membrane (GO:0006612)3.30382542
57spliceosomal snRNP assembly (GO:0000387)3.28448342
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27136971
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27136971
60somite rostral/caudal axis specification (GO:0032525)3.23923994
61RNA catabolic process (GO:0006401)3.19872542
62regulation of sulfur metabolic process (GO:0042762)3.19713720
63spliceosomal complex assembly (GO:0000245)3.18843071
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15733927
65microtubule depolymerization (GO:0007019)3.12046235
66inner mitochondrial membrane organization (GO:0007007)3.11057700
67termination of RNA polymerase I transcription (GO:0006363)3.08215666
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03927147
69ATP biosynthetic process (GO:0006754)3.02162776
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01701123
71protein neddylation (GO:0045116)3.00806253
72genitalia morphogenesis (GO:0035112)3.00528798
73GMP metabolic process (GO:0046037)3.00077355
74cellular component biogenesis (GO:0044085)2.97596220
75IMP biosynthetic process (GO:0006188)2.96701755
76mitochondrial respiratory chain complex assembly (GO:0033108)2.96116740
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.91678541
78NADH dehydrogenase complex assembly (GO:0010257)2.91678541
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91678541
80ATP-dependent chromatin remodeling (GO:0043044)2.85706130
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85038850
82purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84922630
83heterochromatin organization (GO:0070828)2.82511957
84protein complex biogenesis (GO:0070271)2.82324687
85histone mRNA metabolic process (GO:0008334)2.80553068
86regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79395473
87mRNA splice site selection (GO:0006376)2.79321365
88termination of RNA polymerase II transcription (GO:0006369)2.79153199
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77557853
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.77523994
91regulation of helicase activity (GO:0051095)2.76803962
92DNA-templated transcription, termination (GO:0006353)2.76691351
93protein localization to cilium (GO:0061512)2.72568506
94single strand break repair (GO:0000012)2.71395746
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69561930
96female gonad development (GO:0008585)2.69009806
97regulation of coenzyme metabolic process (GO:0051196)2.68069164
98regulation of cofactor metabolic process (GO:0051193)2.68069164
99rRNA processing (GO:0006364)2.67527045
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66529695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.03496793
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.03064973
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.98538960
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.92850201
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.51095735
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.36488151
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.35237584
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04335913
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.89902408
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87782430
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.84196245
12ELK1_19687146_ChIP-ChIP_HELA_Human2.83923234
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82778363
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.67892073
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58823882
16E2F7_22180533_ChIP-Seq_HELA_Human2.54778080
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54341815
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.45377589
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41255586
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29021654
21EWS_26573619_Chip-Seq_HEK293_Human2.24241494
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11043202
23FUS_26573619_Chip-Seq_HEK293_Human2.06349364
24TTF2_22483619_ChIP-Seq_HELA_Human1.99605356
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.98907408
26MYC_18940864_ChIP-ChIP_HL60_Human1.95127771
27VDR_23849224_ChIP-Seq_CD4+_Human1.94235390
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88658329
29XRN2_22483619_ChIP-Seq_HELA_Human1.83858327
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80789578
31VDR_22108803_ChIP-Seq_LS180_Human1.79674255
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78270930
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73452053
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72675933
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69705019
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68486319
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.68441976
38P300_19829295_ChIP-Seq_ESCs_Human1.61557064
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59130380
40FOXP3_21729870_ChIP-Seq_TREG_Human1.56182551
41ZNF274_21170338_ChIP-Seq_K562_Hela1.52944691
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.51759036
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50311112
44DCP1A_22483619_ChIP-Seq_HELA_Human1.50093179
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49659893
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.47342360
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.44853020
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41703043
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.40412534
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40272488
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39465261
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38205119
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37393490
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33244829
55AR_21909140_ChIP-Seq_LNCAP_Human1.32690607
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31011415
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30029925
58TAF15_26573619_Chip-Seq_HEK293_Human1.28669354
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26718173
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26694346
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22231997
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20804866
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.20605749
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15980469
65RNF2_27304074_Chip-Seq_NSC_Mouse1.14613824
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.11438188
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.09768499
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08840783
69IGF1R_20145208_ChIP-Seq_DFB_Human1.07994464
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07700834
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.07141922
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06726921
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01289827
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01168629
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00600236
76TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99478205
77CBP_20019798_ChIP-Seq_JUKART_Human0.98321632
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98321632
79NANOG_19829295_ChIP-Seq_ESCs_Human0.98062145
80SOX2_19829295_ChIP-Seq_ESCs_Human0.98062145
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97502232
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97441996
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95353455
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92825894
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92446670
86TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92380330
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91241685
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90085903
89TP53_22573176_ChIP-Seq_HFKS_Human0.90030327
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89980392
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89969569
92IRF1_19129219_ChIP-ChIP_H3396_Human0.89895664
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86410211
94HTT_18923047_ChIP-ChIP_STHdh_Human0.85664184
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85188935
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.84895092
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83778526
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83609352
99MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83286759
100SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80973346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.66024091
2MP0003890_abnormal_embryonic-extraembry4.14570407
3MP0003315_abnormal_perineum_morphology3.12325386
4MP0001529_abnormal_vocalization3.05821549
5MP0002277_abnormal_respiratory_mucosa2.82529303
6MP0005187_abnormal_penis_morphology2.80924058
7MP0003136_yellow_coat_color2.77938877
8MP0001188_hyperpigmentation2.51852467
9MP0005377_hearing/vestibular/ear_phenot2.39159890
10MP0003878_abnormal_ear_physiology2.39159890
11MP0004957_abnormal_blastocyst_morpholog2.30666633
12MP0006292_abnormal_olfactory_placode2.28070808
13MP0002938_white_spotting2.22300091
14MP0003119_abnormal_digestive_system2.17277485
15MP0008058_abnormal_DNA_repair2.09424472
16MP0010094_abnormal_chromosome_stability2.08161715
17MP0008995_early_reproductive_senescence2.07207897
18MP0000372_irregular_coat_pigmentation2.00243254
19MP0003941_abnormal_skin_development1.99626157
20MP0004133_heterotaxia1.90146077
21MP0003186_abnormal_redox_activity1.89792458
22MP0002736_abnormal_nociception_after1.82659370
23MP0003880_abnormal_central_pattern1.78985580
24MP0001293_anophthalmia1.76442246
25MP0009697_abnormal_copulation1.72811047
26MP0002697_abnormal_eye_size1.71956868
27MP0000569_abnormal_digit_pigmentation1.70611845
28MP0003718_maternal_effect1.66384763
29MP0002751_abnormal_autonomic_nervous1.65696502
30MP0001286_abnormal_eye_development1.64720843
31MP0002928_abnormal_bile_duct1.50505905
32MP0000647_abnormal_sebaceous_gland1.48710417
33MP0003567_abnormal_fetal_cardiomyocyte1.48537918
34MP0001919_abnormal_reproductive_system1.48371508
35MP0003077_abnormal_cell_cycle1.45264055
36MP0001879_abnormal_lymphatic_vessel1.45007993
37MP0006276_abnormal_autonomic_nervous1.44629919
38MP0003121_genomic_imprinting1.44392054
39MP0003123_paternal_imprinting1.42614813
40MP0008932_abnormal_embryonic_tissue1.40778885
41MP0000631_abnormal_neuroendocrine_gland1.36150998
42MP0002210_abnormal_sex_determination1.33492269
43MP0000778_abnormal_nervous_system1.30582038
44MP0008789_abnormal_olfactory_epithelium1.26340602
45MP0002163_abnormal_gland_morphology1.25096221
46MP0006035_abnormal_mitochondrial_morpho1.23023449
47MP0002837_dystrophic_cardiac_calcinosis1.21971095
48MP0005084_abnormal_gallbladder_morpholo1.16753905
49MP0006072_abnormal_retinal_apoptosis1.16366562
50MP0001968_abnormal_touch/_nociception1.14986870
51MP0001984_abnormal_olfaction1.14826464
52MP0002234_abnormal_pharynx_morphology1.13734260
53MP0006054_spinal_hemorrhage1.12680969
54MP0005394_taste/olfaction_phenotype1.10277528
55MP0005499_abnormal_olfactory_system1.10277528
56MP0001485_abnormal_pinna_reflex1.08922741
57MP0003937_abnormal_limbs/digits/tail_de1.06004156
58MP0003938_abnormal_ear_development1.03048006
59MP0003111_abnormal_nucleus_morphology0.98201452
60MP0001324_abnormal_eye_pigmentation0.97824765
61MP0003221_abnormal_cardiomyocyte_apopto0.97133107
62MP0005389_reproductive_system_phenotype0.96938885
63MP0001929_abnormal_gametogenesis0.95727056
64MP0002085_abnormal_embryonic_tissue0.94559270
65MP0008057_abnormal_DNA_replication0.94437898
66MP0003693_abnormal_embryo_hatching0.91143352
67MP0002734_abnormal_mechanical_nocicepti0.90734208
68MP0005075_abnormal_melanosome_morpholog0.88980068
69MP0004742_abnormal_vestibular_system0.85540195
70MP0000653_abnormal_sex_gland0.85443631
71MP0002233_abnormal_nose_morphology0.84828860
72MP0003806_abnormal_nucleotide_metabolis0.84145325
73MP0001672_abnormal_embryogenesis/_devel0.84122317
74MP0005380_embryogenesis_phenotype0.84122317
75MP0001346_abnormal_lacrimal_gland0.83567795
76MP0000049_abnormal_middle_ear0.83129721
77MP0003861_abnormal_nervous_system0.81535138
78MP0002089_abnormal_postnatal_growth/wei0.81409804
79MP0008961_abnormal_basal_metabolism0.80515812
80MP0002090_abnormal_vision0.80273360
81MP0003195_calcinosis0.80187978
82MP0005195_abnormal_posterior_eye0.80017858
83MP0002084_abnormal_developmental_patter0.79387897
84MP0002557_abnormal_social/conspecific_i0.78412038
85MP0003698_abnormal_male_reproductive0.78296609
86MP0000955_abnormal_spinal_cord0.77245466
87MP0003122_maternal_imprinting0.77181993
88MP0005167_abnormal_blood-brain_barrier0.76909254
89MP0005379_endocrine/exocrine_gland_phen0.76882127
90MP0005551_abnormal_eye_electrophysiolog0.76326109
91MP0005408_hypopigmentation0.76245014
92MP0002735_abnormal_chemical_nociception0.75180382
93MP0002088_abnormal_embryonic_growth/wei0.74098957
94MP0001145_abnormal_male_reproductive0.72897459
95MP0003984_embryonic_growth_retardation0.72736463
96MP0002161_abnormal_fertility/fecundity0.71909160
97MP0000350_abnormal_cell_proliferation0.70047755
98MP0009672_abnormal_birth_weight0.69888682
99MP0004270_analgesia0.69681242
100MP0001119_abnormal_female_reproductive0.69369049

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.45210809
2Acute necrotizing encephalopathy (HP:0006965)4.07342394
3Absent septum pellucidum (HP:0001331)3.91962453
4Septo-optic dysplasia (HP:0100842)3.87602884
5Abnormal number of erythroid precursors (HP:0012131)3.71861506
6Abnormality of cells of the erythroid lineage (HP:0012130)3.70375128
7Abnormality of the septum pellucidum (HP:0007375)3.62124690
8Increased hepatocellular lipid droplets (HP:0006565)3.58336854
9Macrocytic anemia (HP:0001972)3.51885470
10Mitochondrial inheritance (HP:0001427)3.44237037
11Progressive macrocephaly (HP:0004481)3.43137714
12Lipid accumulation in hepatocytes (HP:0006561)3.41266443
13Abnormal mitochondria in muscle tissue (HP:0008316)3.36679273
14Acute encephalopathy (HP:0006846)3.28221109
15Hepatic necrosis (HP:0002605)3.17900725
16Colon cancer (HP:0003003)3.15584768
17Increased CSF lactate (HP:0002490)3.15565738
18Hepatocellular necrosis (HP:0001404)3.10244436
19Congenital, generalized hypertrichosis (HP:0004540)3.01861467
20Pancreatic cysts (HP:0001737)2.94701202
21Renal Fanconi syndrome (HP:0001994)2.83432390
22Hyperglycinemia (HP:0002154)2.74083297
23Limb dystonia (HP:0002451)2.72993560
24Cerebral edema (HP:0002181)2.66289589
25Maternal diabetes (HP:0009800)2.64376733
26Optic disc pallor (HP:0000543)2.61532206
27Hypoplastic left heart (HP:0004383)2.61282488
28Supernumerary spleens (HP:0009799)2.60894563
29Bilateral microphthalmos (HP:0007633)2.60300781
30Pallor (HP:0000980)2.59431961
31Pendular nystagmus (HP:0012043)2.57547675
32Confusion (HP:0001289)2.54609240
33Abnormality of renal resorption (HP:0011038)2.51895866
34Hyperglycinuria (HP:0003108)2.40063192
35Generalized aminoaciduria (HP:0002909)2.39699311
36Abnormality of the labia minora (HP:0012880)2.36176983
37Attenuation of retinal blood vessels (HP:0007843)2.31893560
38Carpal bone hypoplasia (HP:0001498)2.30662118
39Abnormal lung lobation (HP:0002101)2.30302217
40True hermaphroditism (HP:0010459)2.28923076
41Hypoplasia of the pons (HP:0012110)2.22918683
42Amniotic constriction ring (HP:0009775)2.21721844
43Abnormality of placental membranes (HP:0011409)2.21721844
44Abnormality of the pons (HP:0007361)2.20397913
45Leukodystrophy (HP:0002415)2.18359553
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18083323
47Meckel diverticulum (HP:0002245)2.17551251
48Pancreatic fibrosis (HP:0100732)2.13012701
49Hypoplastic heart (HP:0001961)2.11648940
50Woolly hair (HP:0002224)2.11498027
51Anencephaly (HP:0002323)2.10805926
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09484059
53Cortical dysplasia (HP:0002539)2.08444272
54Hypothermia (HP:0002045)2.05923930
55Myelomeningocele (HP:0002475)2.05290587
56Exertional dyspnea (HP:0002875)2.03836936
57Absent eyebrow (HP:0002223)2.03216174
58Anophthalmia (HP:0000528)2.02896122
59Optic nerve hypoplasia (HP:0000609)2.00317063
60Rectal fistula (HP:0100590)1.98608826
61Rectovaginal fistula (HP:0000143)1.98608826
62Abnormality of the ileum (HP:0001549)1.97726011
63Abnormality of methionine metabolism (HP:0010901)1.97212790
64Triphalangeal thumb (HP:0001199)1.92237493
65Abnormal rod and cone electroretinograms (HP:0008323)1.92134255
66Febrile seizures (HP:0002373)1.91659558
67Flat occiput (HP:0005469)1.89846508
68Volvulus (HP:0002580)1.88089805
69Respiratory difficulties (HP:0002880)1.86677720
70Glycosuria (HP:0003076)1.84092587
71Abnormality of urine glucose concentration (HP:0011016)1.84092587
72Abnormality of serum amino acid levels (HP:0003112)1.82706302
73Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82491149
74Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80767040
75Molar tooth sign on MRI (HP:0002419)1.79243818
76Abnormality of midbrain morphology (HP:0002418)1.79243818
77Hypogonadotrophic hypogonadism (HP:0000044)1.79048434
78Parakeratosis (HP:0001036)1.78559118
79Aplastic anemia (HP:0001915)1.77661421
80Increased serum lactate (HP:0002151)1.77071565
81Abnormal hair whorl (HP:0010721)1.75856709
82Absent hair (HP:0002298)1.75305628
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74756850
84Nephronophthisis (HP:0000090)1.72862979
85Dysphonia (HP:0001618)1.72757697
86Exercise intolerance (HP:0003546)1.70273067
87Hypoglycemic coma (HP:0001325)1.70217321
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.69868126
89Dandy-Walker malformation (HP:0001305)1.69631672
90Polyuria (HP:0000103)1.69412084
91Oligodactyly (hands) (HP:0001180)1.68540779
92Proximal tubulopathy (HP:0000114)1.67465857
93Sparse eyelashes (HP:0000653)1.66911150
94Abnormality of chromosome stability (HP:0003220)1.66553169
95X-linked dominant inheritance (HP:0001423)1.66518087
96Lactic acidosis (HP:0003128)1.65073893
97Restlessness (HP:0000711)1.64906136
98Atrioventricular canal defect (HP:0006695)1.64581223
99Reduced antithrombin III activity (HP:0001976)1.63265839
100Cellular immunodeficiency (HP:0005374)1.63037982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK8.12664237
2VRK24.91656894
3TRIM282.90001140
4NLK2.71282172
5MARK12.45555485
6DYRK32.45126180
7CDC72.41764372
8BUB12.35163212
9PASK2.22179607
10EIF2AK32.13475409
11TSSK62.10316031
12SRPK12.07723161
13AKT32.02719293
14TAF11.91271341
15VRK11.91125129
16MUSK1.81925779
17MKNK21.78199314
18MAP3K101.67348364
19ZAK1.66044123
20EIF2AK11.62743204
21MKNK11.57260810
22NME11.44242284
23PNCK1.43752620
24PLK41.39595374
25NEK11.39524031
26TTK1.37504683
27DYRK21.32496181
28PLK31.28780038
29PBK1.25208568
30BRAF1.11055773
31GRK71.08144029
32TLK11.07044385
33FLT31.06197048
34MST41.06100412
35ACVR1B0.97517904
36STK160.97207475
37RPS6KA40.96025717
38WNK30.95651384
39FGFR10.89079886
40PKN20.88031349
41DMPK0.86738131
42NEK20.81756033
43MAP3K40.79484109
44NME20.75473797
45NTRK20.75322159
46CSNK1G20.71786341
47KDR0.69782797
48ALK0.68498627
49OXSR10.68464220
50CASK0.66801605
51BCKDK0.65080492
52EPHB20.64885314
53PDK20.61573788
54NTRK10.61068624
55DYRK1A0.60948090
56MAP2K70.58110402
57AURKB0.56746060
58CSNK2A20.56689716
59CDK80.56006672
60TGFBR10.55127928
61CSNK1G10.54960061
62GRK10.54887708
63WEE10.54787597
64SGK20.53866848
65CHUK0.53628517
66NUAK10.53519700
67CSNK2A10.52284540
68CSNK1G30.48326553
69ADRBK20.48093946
70BCR0.47880862
71RPS6KA50.47095309
72PRKCG0.45763117
73STK390.44914181
74CSNK1E0.44160772
75PLK10.42939888
76CSNK1A1L0.41296946
77CHEK20.41288188
78NTRK30.41118834
79PINK10.39822113
80CDK30.39458980
81TYRO30.37336303
82TYK20.36726023
83PLK20.36421120
84CSNK1A10.35615886
85DYRK1B0.32885003
86ATR0.30966040
87IKBKE0.30959369
88PRKG10.30541875
89WNK40.26345706
90KIT0.25881047
91MINK10.25158875
92ATM0.23543636
93PRKCB0.22847215
94MAPK150.22688109
95MAP2K60.22404429
96PTK60.21769845
97ADRBK10.21571857
98STK40.20296540
99MATK0.20295684
100CHEK10.19660400

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.81206843
2Proteasome_Homo sapiens_hsa030504.27446570
3Oxidative phosphorylation_Homo sapiens_hsa001904.14814247
4Parkinsons disease_Homo sapiens_hsa050123.44411456
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95543959
6Huntingtons disease_Homo sapiens_hsa050162.73556995
7RNA polymerase_Homo sapiens_hsa030202.69591699
8Mismatch repair_Homo sapiens_hsa034302.48001299
9Spliceosome_Homo sapiens_hsa030402.45745395
10Alzheimers disease_Homo sapiens_hsa050102.41193949
11Protein export_Homo sapiens_hsa030602.25548564
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06250424
13Non-homologous end-joining_Homo sapiens_hsa034502.04448307
14Homologous recombination_Homo sapiens_hsa034401.95639312
15Cardiac muscle contraction_Homo sapiens_hsa042601.94698804
16RNA transport_Homo sapiens_hsa030131.93456432
17DNA replication_Homo sapiens_hsa030301.90418408
18RNA degradation_Homo sapiens_hsa030181.85884661
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83083357
20One carbon pool by folate_Homo sapiens_hsa006701.82011146
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.74678966
22Basal transcription factors_Homo sapiens_hsa030221.70907902
23Pyruvate metabolism_Homo sapiens_hsa006201.57365800
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44375851
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42583580
26Base excision repair_Homo sapiens_hsa034101.42133257
27Basal cell carcinoma_Homo sapiens_hsa052171.33355907
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29924358
29Thyroid cancer_Homo sapiens_hsa052161.24690222
30mRNA surveillance pathway_Homo sapiens_hsa030151.22990496
31Purine metabolism_Homo sapiens_hsa002301.19176136
32Nucleotide excision repair_Homo sapiens_hsa034201.18301327
33Selenocompound metabolism_Homo sapiens_hsa004501.17146104
34Phototransduction_Homo sapiens_hsa047441.13376185
35Fanconi anemia pathway_Homo sapiens_hsa034601.13115604
36Propanoate metabolism_Homo sapiens_hsa006401.10633774
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07991321
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.07671046
39Steroid biosynthesis_Homo sapiens_hsa001001.03974141
40Pyrimidine metabolism_Homo sapiens_hsa002401.01393553
41Cell cycle_Homo sapiens_hsa041101.01253265
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00134389
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96767600
44Wnt signaling pathway_Homo sapiens_hsa043100.89029144
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81749565
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81370199
47p53 signaling pathway_Homo sapiens_hsa041150.74572676
48Nicotine addiction_Homo sapiens_hsa050330.71728765
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66868246
50Mineral absorption_Homo sapiens_hsa049780.66720160
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61187749
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60327925
53Starch and sucrose metabolism_Homo sapiens_hsa005000.57487950
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56469056
55Tryptophan metabolism_Homo sapiens_hsa003800.56186642
56Metabolic pathways_Homo sapiens_hsa011000.55586965
57Epstein-Barr virus infection_Homo sapiens_hsa051690.54349488
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53169805
59Butanoate metabolism_Homo sapiens_hsa006500.52295969
60Biosynthesis of amino acids_Homo sapiens_hsa012300.50036408
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48629504
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45933739
63Hippo signaling pathway_Homo sapiens_hsa043900.42047471
64Olfactory transduction_Homo sapiens_hsa047400.41898638
65Vitamin digestion and absorption_Homo sapiens_hsa049770.41347208
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41172467
67Taste transduction_Homo sapiens_hsa047420.40943255
68Glutathione metabolism_Homo sapiens_hsa004800.38245912
69Carbon metabolism_Homo sapiens_hsa012000.37773526
70Caffeine metabolism_Homo sapiens_hsa002320.37613347
71Colorectal cancer_Homo sapiens_hsa052100.35893821
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34692200
73Oocyte meiosis_Homo sapiens_hsa041140.34232363
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33852714
75Collecting duct acid secretion_Homo sapiens_hsa049660.32438944
76Folate biosynthesis_Homo sapiens_hsa007900.32284839
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31327801
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30989391
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30578328
80Adherens junction_Homo sapiens_hsa045200.29121733
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28327131
82Systemic lupus erythematosus_Homo sapiens_hsa053220.26747245
83Regulation of autophagy_Homo sapiens_hsa041400.25087923
84Chemical carcinogenesis_Homo sapiens_hsa052040.24707550
85Phenylalanine metabolism_Homo sapiens_hsa003600.21749138
86Tyrosine metabolism_Homo sapiens_hsa003500.18986618
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18517724
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18202242
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17843340
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17387252
91Retinol metabolism_Homo sapiens_hsa008300.13209291
92Serotonergic synapse_Homo sapiens_hsa047260.12948284
93Histidine metabolism_Homo sapiens_hsa003400.11270906
94Prostate cancer_Homo sapiens_hsa052150.10941893
95Linoleic acid metabolism_Homo sapiens_hsa005910.10485840
96Alcoholism_Homo sapiens_hsa050340.10015865
97Ether lipid metabolism_Homo sapiens_hsa005650.09087927
98Fat digestion and absorption_Homo sapiens_hsa049750.07208623
99Hedgehog signaling pathway_Homo sapiens_hsa043400.06517482
100Nitrogen metabolism_Homo sapiens_hsa009100.06293275

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