ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of somitogenesis (GO:0014807)	7.81045452
2	otic vesicle formation (GO:0030916)	6.96209822
3	prenylation (GO:0097354)	6.93883541
4	protein prenylation (GO:0018342)	6.93883541
5	mesonephros development (GO:0001823)	6.25385299
6	DNA replication-dependent nucleosome organization (GO:0034723)	6.23922339
7	DNA replication-dependent nucleosome assembly (GO:0006335)	6.23922339
8	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	5.64596638
9	lymphangiogenesis (GO:0001946)	5.40835858
10	viral mRNA export from host cell nucleus (GO:0046784)	5.33742144
11	membrane protein intracellular domain proteolysis (GO:0031293)	5.33347269
12	negative regulation of glycogen metabolic process (GO:0070874)	5.27931698
13	membrane protein ectodomain proteolysis (GO:0006509)	5.05607892
14	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	4.97235646
15	pharyngeal system development (GO:0060037)	4.91939701
16	lung morphogenesis (GO:0060425)	4.91209135
17	negative regulation of cardiac muscle tissue development (GO:0055026)	4.83063396
18	fat-soluble vitamin catabolic process (GO:0042363)	4.82871517
19	vitamin catabolic process (GO:0009111)	4.82871517
20	sulfation (GO:0051923)	4.81184933
21	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	4.62461986
22	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	4.46098849
23	adult heart development (GO:0007512)	4.44872541
24	cell proliferation in forebrain (GO:0021846)	4.43637812
25	branching involved in salivary gland morphogenesis (GO:0060445)	4.40662992
26	embryonic hindlimb morphogenesis (GO:0035116)	4.35087571
27	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	4.22526717
28	cell migration involved in gastrulation (GO:0042074)	4.19998915
29	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	4.13688260
30	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	4.11973954
31	adrenergic receptor signaling pathway (GO:0071875)	4.10774436
32	regulation of DNA damage checkpoint (GO:2000001)	4.05812969
33	DNA integration (GO:0015074)	4.05045890
34	anterior/posterior axis specification, embryo (GO:0008595)	3.91966370
35	organ growth (GO:0035265)	3.86121219
36	post-anal tail morphogenesis (GO:0036342)	3.79884539
37	positive regulation of RNA splicing (GO:0033120)	3.74887761
38	IMP biosynthetic process (GO:0006188)	3.71941950
39	venous blood vessel morphogenesis (GO:0048845)	3.69660522
40	positive regulation of heart rate (GO:0010460)	3.64987976
41	dopaminergic neuron differentiation (GO:0071542)	3.64361859
42	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.61413154
43	morphogenesis of embryonic epithelium (GO:0016331)	3.59581496
44	male genitalia development (GO:0030539)	3.54679287
45	heparin biosynthetic process (GO:0030210)	3.54320096
46	heparin metabolic process (GO:0030202)	3.54320096
47	thyroid gland development (GO:0030878)	3.53822875
48	hindlimb morphogenesis (GO:0035137)	3.45237377
49	forebrain morphogenesis (GO:0048853)	3.31880638
50	desmosome organization (GO:0002934)	3.25216274
51	membrane protein proteolysis (GO:0033619)	3.21038030
52	cell wall macromolecule catabolic process (GO:0016998)	3.20244641
53	eyelid development in camera-type eye (GO:0061029)	3.18260674
54	rRNA catabolic process (GO:0016075)	3.15832596
55	positive regulation of glycogen metabolic process (GO:0070875)	3.15743418
56	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13411816
57	NADH dehydrogenase complex assembly (GO:0010257)	3.13411816
58	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13411816
59	embryonic skeletal joint morphogenesis (GO:0060272)	3.08370487
60	aorta morphogenesis (GO:0035909)	3.06487266
61	embryonic forelimb morphogenesis (GO:0035115)	3.05792974
62	negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)	3.05226224
63	auditory receptor cell differentiation (GO:0042491)	3.01757125
64	branching involved in mammary gland duct morphogenesis (GO:0060444)	3.01452085
65	outflow tract septum morphogenesis (GO:0003148)	3.00352786
66	organ induction (GO:0001759)	2.92769211
67	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.89560205
68	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.87980685
69	negative regulation of Rho protein signal transduction (GO:0035024)	2.85234838
70	trophoblast giant cell differentiation (GO:0060707)	2.82498820
71	negative regulation of viral release from host cell (GO:1902187)	2.81493836
72	intestinal epithelial cell development (GO:0060576)	2.81136117
73	regulation of histone H3-K27 methylation (GO:0061085)	2.80917435
74	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.79787851
75	endoderm formation (GO:0001706)	2.78638916
76	negative regulation of protein tyrosine kinase activity (GO:0061099)	2.77786812
77	regulation of gene expression by genetic imprinting (GO:0006349)	2.76776237
78	DNA methylation involved in gamete generation (GO:0043046)	2.76029906
79	blood vessel remodeling (GO:0001974)	2.73784395
80	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.73420379
81	positive regulation of fatty acid oxidation (GO:0046321)	2.70633602
82	regulation of cell proliferation involved in kidney development (GO:1901722)	2.69847292
83	IMP metabolic process (GO:0046040)	2.69421460
84	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	2.69224206
85	forebrain neuron development (GO:0021884)	2.69085218
86	forelimb morphogenesis (GO:0035136)	2.68860750
87	regulation of axon extension involved in axon guidance (GO:0048841)	2.67737999
88	lateral sprouting from an epithelium (GO:0060601)	2.67238744
89	positive regulation of mitosis (GO:0045840)	2.66654204
90	regulation of megakaryocyte differentiation (GO:0045652)	2.65807058
91	regulation of glomerulus development (GO:0090192)	2.65757225
92	positive regulation of mRNA metabolic process (GO:1903313)	2.64268085
93	prostate gland growth (GO:0060736)	2.63475487
94	cardiac epithelial to mesenchymal transition (GO:0060317)	2.61311291
95	T cell mediated immunity (GO:0002456)	2.61111219
96	cell wall macromolecule metabolic process (GO:0044036)	2.60391998
97	negative regulation of gluconeogenesis (GO:0045721)	2.59179285
98	reproductive system development (GO:0061458)	2.58807777
99	response to UV-C (GO:0010225)	2.56056594
100	regulation of the force of heart contraction (GO:0002026)	2.55822838

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	7.40311775
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.90556675
3	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.89670860
4	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.61673298
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53402761
6	AR_21572438_ChIP-Seq_LNCaP_Human	2.39696713
7	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.25924704
8	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.18037876
9	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.00919065
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	14.8047562
11	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.93519994
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.91769540
13	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.91751728
14	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.86972955
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.77512288
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75330060
17	AHR_22903824_ChIP-Seq_MCF-7_Human	1.70662325
18	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.68297633
19	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.68061775
20	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.57272637
21	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.56758883
22	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.56758883
23	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.56758883
24	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.55519878
25	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.46801902
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44782942
27	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.42707239
28	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.40911017
29	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38314971
30	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.35099662
31	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.32485371
32	EZH2_22144423_ChIP-Seq_EOC_Human	1.24835256
33	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.21733381
34	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.17113653
35	VDR_22108803_ChIP-Seq_LS180_Human	1.16949311
36	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.15417800
37	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.14312056
38	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.12740970
39	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.11994822
40	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.11405859
41	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.11405859
42	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.11083902
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.10541465
44	CJUN_26792858_Chip-Seq_BT549_Human	1.09676717
45	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.08489798
46	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.06361356
47	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.05395741
48	GBX2_23144817_ChIP-Seq_PC3_Human	1.01449857
49	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.00921722
50	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.00395438
51	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.98019811
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96897345
53	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.95508982
54	TP53_16413492_ChIP-PET_HCT116_Human	0.93154308
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.91590454
56	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.91248626
57	ZNF274_21170338_ChIP-Seq_K562_Hela	0.88888400
58	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	0.86491697
59	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.83836600
60	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.83836600
61	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.83766918
62	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.83723816
63	IGF1R_20145208_ChIP-Seq_DFB_Human	0.82145628
64	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.81806312
65	FUS_26573619_Chip-Seq_HEK293_Human	0.81176207
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.80477851
67	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.80132041
68	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.79979085
69	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.79058296
70	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.78209833
71	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.77067671
72	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.76847326
73	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.75789828
74	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.75368339
75	ER_23166858_ChIP-Seq_MCF-7_Human	0.75291928
76	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.74976268
77	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.73559261
78	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.72088129
79	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.71868722
80	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.71336610
81	IRF1_19129219_ChIP-ChIP_H3396_Human	0.70074689
82	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.69415055
83	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.69261926
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.68123842
85	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.67100143
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.65826834
87	RXR_22108803_ChIP-Seq_LS180_Human	0.64658452
88	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.63073775
89	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.62887294
90	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.61865220
91	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.61628414
92	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.60277276
93	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.60034616
94	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.60033106
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.60018379
96	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.59288397
97	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.58435905
98	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.58154407
99	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.58133448
100	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.56950956

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005083_abnormal_biliary_tract	5.17466626
2	MP0002254_reproductive_system_inflammat	4.56678448
3	MP0002138_abnormal_hepatobiliary_system	4.17992801
4	MP0000678_abnormal_parathyroid_gland	4.15887647
5	MP0000383_abnormal_hair_follicle	3.89117035
6	MP0002160_abnormal_reproductive_system	3.88580169
7	MP0003693_abnormal_embryo_hatching	3.61480079
8	MP0002822_catalepsy	3.57023561
9	MP0000569_abnormal_digit_pigmentation	3.35087106
10	MP0009780_abnormal_chondrocyte_physiolo	3.33225675
11	MP0005076_abnormal_cell_differentiation	2.79218322
12	MP0005409_darkened_coat_color	2.77568092
13	MP0003191_abnormal_cellular_cholesterol	2.59481220
14	MP0010678_abnormal_skin_adnexa	2.53723885
15	MP0000049_abnormal_middle_ear	2.30074144
16	MP0005389_reproductive_system_phenotype	2.28764356
17	MP0000762_abnormal_tongue_morphology	2.06161037
18	MP0003942_abnormal_urinary_system	1.87630192
19	MP0002249_abnormal_larynx_morphology	1.83303963
20	MP0005423_abnormal_somatic_nervous	1.81506853
21	MP0004885_abnormal_endolymph	1.76969179
22	MP0000467_abnormal_esophagus_morphology	1.75112449
23	MP0006276_abnormal_autonomic_nervous	1.70380517
24	MP0009250_abnormal_appendicular_skeleto	1.68565287
25	MP0000733_abnormal_muscle_development	1.65710829
26	MP0009053_abnormal_anal_canal	1.65150982
27	MP0000579_abnormal_nail_morphology	1.64177087
28	MP0002127_abnormal_cardiovascular_syste	1.54253179
29	MP0004272_abnormal_basement_membrane	1.54013274
30	MP0005647_abnormal_sex_gland	1.53057192
31	MP0000750_abnormal_muscle_regeneration	1.40508118
32	MP0005646_abnormal_pituitary_gland	1.38614478
33	MP0002089_abnormal_postnatal_growth/wei	1.37408287
34	MP0002796_impaired_skin_barrier	1.36585117
35	MP0002108_abnormal_muscle_morphology	1.35250215
36	MP0000534_abnormal_ureter_morphology	1.26884988
37	MP0004197_abnormal_fetal_growth/weight/	1.25811745
38	MP0005503_abnormal_tendon_morphology	1.22388644
39	MP0001270_distended_abdomen	1.18530290
40	MP0001879_abnormal_lymphatic_vessel	1.17704132
41	MP0003941_abnormal_skin_development	1.17594099
42	MP0001340_abnormal_eyelid_morphology	1.15803724
43	MP0002111_abnormal_tail_morphology	1.15295614
44	MP0002139_abnormal_hepatobiliary_system	1.14813444
45	MP0000681_abnormal_thyroid_gland	1.14698973
46	MP0003937_abnormal_limbs/digits/tail_de	1.13116954
47	MP0002009_preneoplasia	1.13016054
48	MP0002116_abnormal_craniofacial_bone	1.10786683
49	MP0003880_abnormal_central_pattern	1.09537591
50	MP0004134_abnormal_chest_morphology	1.08941209
51	MP0004782_abnormal_surfactant_physiolog	1.08435649
52	MP0002060_abnormal_skin_morphology	1.07840725
53	MP0000163_abnormal_cartilage_morphology	1.05494672
54	MP0003935_abnormal_craniofacial_develop	1.05436640
55	MP0000767_abnormal_smooth_muscle	1.02084286
56	MP0003828_pulmonary_edema	1.00539811
57	MP0000613_abnormal_salivary_gland	0.97041220
58	MP0002928_abnormal_bile_duct	0.96670302
59	MP0003755_abnormal_palate_morphology	0.96366389
60	MP0010368_abnormal_lymphatic_system	0.94705419
61	MP0000631_abnormal_neuroendocrine_gland	0.92411652
62	MP0004085_abnormal_heartbeat	0.90994882
63	MP0000428_abnormal_craniofacial_morphol	0.90738904
64	MP0002932_abnormal_joint_morphology	0.89104815
65	MP0004270_analgesia	0.88360509
66	MP0002282_abnormal_trachea_morphology	0.85439240
67	MP0002396_abnormal_hematopoietic_system	0.85276103
68	MP0003252_abnormal_bile_duct	0.85099394
69	MP0009278_abnormal_bone_marrow	0.84807420
70	MP0001216_abnormal_epidermal_layer	0.84287960
71	MP0001873_stomach_inflammation	0.84283200
72	MP0003890_abnormal_embryonic-extraembry	0.83021303
73	MP0002971_abnormal_brown_adipose	0.80135042
74	MP0003866_abnormal_defecation	0.80124809
75	MP0006138_congestive_heart_failure	0.78987780
76	MP0003936_abnormal_reproductive_system	0.78426932
77	MP0005377_hearing/vestibular/ear_phenot	0.77195804
78	MP0003878_abnormal_ear_physiology	0.77195804
79	MP0009115_abnormal_fat_cell	0.76713774
80	MP0004264_abnormal_extraembryonic_tissu	0.75870587
81	MP0005595_abnormal_vascular_smooth	0.75362279
82	MP0010771_integument_phenotype	0.73702290
83	MP0005508_abnormal_skeleton_morphology	0.70360839
84	MP0005085_abnormal_gallbladder_physiolo	0.70360185
85	MP0004510_myositis	0.70172380
86	MP0004484_altered_response_of	0.60361919
87	MP0008770_decreased_survivor_rate	0.60013016
88	MP0001485_abnormal_pinna_reflex	0.59258329
89	MP0002109_abnormal_limb_morphology	0.58071125
90	MP0003077_abnormal_cell_cycle	0.57197686
91	MP0002114_abnormal_axial_skeleton	0.56835070
92	MP0002135_abnormal_kidney_morphology	0.55264110
93	MP0002177_abnormal_outer_ear	0.55197306
94	MP0005390_skeleton_phenotype	0.54957664
95	MP0004957_abnormal_blastocyst_morpholog	0.52441715
96	MP0002896_abnormal_bone_mineralization	0.50552319
97	MP0003638_abnormal_response/metabolism_	0.50200751
98	MP0009765_abnormal_xenobiotic_induced	0.50028077
99	MP0009840_abnormal_foam_cell	0.49523275
100	MP0001784_abnormal_fluid_regulation	0.48489449

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Anomalous pulmonary venous return (HP:0010772)	7.21140705
2	Abnormality of the pulmonary veins (HP:0011718)	6.35189297
3	Oral leukoplakia (HP:0002745)	6.02078472
4	Tongue fasciculations (HP:0001308)	5.60837170
5	Muscle fibrillation (HP:0010546)	4.98862184
6	Slow saccadic eye movements (HP:0000514)	4.34354526
7	Aortic regurgitation (HP:0001659)	3.86423952
8	Fibular aplasia (HP:0002990)	3.85625487
9	Lymphangioma (HP:0100764)	3.75259856
10	Oligodontia (HP:0000677)	3.62832517
11	Myelomeningocele (HP:0002475)	3.43593871
12	Abnormality of the nasal septum (HP:0000419)	3.33860749
13	Abnormality of the odontoid process (HP:0003310)	3.30719704
14	Rectal prolapse (HP:0002035)	3.29000168
15	Urethral obstruction (HP:0000796)	3.27539790
16	Coronal craniosynostosis (HP:0004440)	3.26674922
17	Impaired smooth pursuit (HP:0007772)	3.25195266
18	Ectopic kidney (HP:0000086)	3.07504480
19	Abnormality of incisor morphology (HP:0011063)	2.97330942
20	Morphological abnormality of the middle ear (HP:0008609)	2.97275627
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.95028599
22	Abnormality of the preputium (HP:0100587)	2.86233139
23	True hermaphroditism (HP:0010459)	2.84982105
24	Pendular nystagmus (HP:0012043)	2.83768943
25	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.81400692
26	Rough bone trabeculation (HP:0100670)	2.78669221
27	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.78627741
28	Squamous cell carcinoma (HP:0002860)	2.77552122
29	Gonadotropin excess (HP:0000837)	2.75649403
30	Abnormal pancreas size (HP:0012094)	2.73037922
31	Cutaneous finger syndactyly (HP:0010554)	2.70683023
32	Abnormality of the intervertebral disk (HP:0005108)	2.68926075
33	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.65739267
34	Abnormality of ocular smooth pursuit (HP:0000617)	2.61248740
35	Abnormality of nail color (HP:0100643)	2.49658955
36	Abnormality of the frontal sinuses (HP:0002687)	2.47369749
37	Severe visual impairment (HP:0001141)	2.43949737
38	Small hand (HP:0200055)	2.41779446
39	Concave nail (HP:0001598)	2.41710560
40	Pancreatic cysts (HP:0001737)	2.41546469
41	Conical tooth (HP:0000698)	2.40537986
42	Periauricular skin pits (HP:0100277)	2.36490554
43	Preauricular pit (HP:0004467)	2.36490554
44	Lip pit (HP:0100267)	2.35464224
45	Pancreatic fibrosis (HP:0100732)	2.33048402
46	Long nose (HP:0003189)	2.32253218
47	Skin pits (HP:0100276)	2.30829107
48	Abnormal albumin level (HP:0012116)	2.27000153
49	Hypoalbuminemia (HP:0003073)	2.27000153
50	Premature graying of hair (HP:0002216)	2.24651203
51	Congenital, generalized hypertrichosis (HP:0004540)	2.24588969
52	Cystic liver disease (HP:0006706)	2.22320134
53	Hypoplastic pelvis (HP:0008839)	2.18796399
54	Anal stenosis (HP:0002025)	2.17016959
55	Horseshoe kidney (HP:0000085)	2.16734097
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.16519549
57	Abnormality of the phalanges of the hallux (HP:0010057)	2.16008569
58	Difficulty running (HP:0009046)	2.15229471
59	Prostate neoplasm (HP:0100787)	2.14473467
60	Vertebral fusion (HP:0002948)	2.13571493
61	Cutaneous syndactyly (HP:0012725)	2.09793107
62	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.07086268
63	Short 1st metacarpal (HP:0010034)	2.07086268
64	Spina bifida occulta (HP:0003298)	2.06331752
65	Abnormality of the 2nd finger (HP:0004100)	2.03864807
66	Persistence of primary teeth (HP:0006335)	2.03538531
67	Woolly hair (HP:0002224)	2.03475785
68	Abnormality of chromosome stability (HP:0003220)	2.02872693
69	Abnormal trabecular bone morphology (HP:0100671)	2.02449462
70	Genetic anticipation (HP:0003743)	2.02351791
71	Narrow palate (HP:0000189)	2.01672698
72	Decreased central vision (HP:0007663)	2.01046276
73	Short phalanx of the thumb (HP:0009660)	2.00854778
74	Increased number of teeth (HP:0011069)	1.98174548
75	Progressive muscle weakness (HP:0003323)	1.97367033
76	Rectovaginal fistula (HP:0000143)	1.97352854
77	Rectal fistula (HP:0100590)	1.97352854
78	Asplenia (HP:0001746)	1.96319859
79	Hemivertebrae (HP:0002937)	1.95567034
80	Clubbing of toes (HP:0100760)	1.93039485
81	Smooth philtrum (HP:0000319)	1.91282492
82	Chromsome breakage (HP:0040012)	1.91120237
83	Hyperkalemia (HP:0002153)	1.90244164
84	Sparse lateral eyebrow (HP:0005338)	1.90151453
85	Hypoplastic iliac wings (HP:0002866)	1.89244443
86	Carpal bone hypoplasia (HP:0001498)	1.88735910
87	Furrowed tongue (HP:0000221)	1.88579064
88	Abnormality of the carotid arteries (HP:0005344)	1.88305281
89	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.87433526
90	Intestinal fistula (HP:0100819)	1.85873317
91	Vertebral arch anomaly (HP:0008438)	1.83631492
92	Hypoplasia of the uterus (HP:0000013)	1.83350270
93	Meckel diverticulum (HP:0002245)	1.82735426
94	Abnormality of the columella (HP:0009929)	1.80702858
95	Radial bowing (HP:0002986)	1.78570600
96	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.78407627
97	Chronic hepatic failure (HP:0100626)	1.78403182
98	Abnormality of the 1st metacarpal (HP:0010009)	1.78081992
99	Abnormality of secondary sexual hair (HP:0009888)	1.77163908
100	Abnormality of the axillary hair (HP:0100134)	1.77163908

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	7.84456503
2	BLK	6.52079193
3	MAP3K9	5.59981301
4	ZAK	5.12972398
5	RIPK1	3.30547716
6	SIK1	2.55811326
7	FGFR1	2.34925514
8	EIF2AK3	2.32784788
9	EPHA2	2.28538177
10	MST1R	2.10275276
11	MAP3K3	1.88397293
12	VRK1	1.69611636
13	MAPK7	1.37957276
14	MAP3K2	1.36168780
15	TNIK	1.30157778
16	CAMK4	1.25927174
17	DAPK2	1.25608268
18	MAP3K10	1.17497531
19	MAP3K7	1.16835424
20	SGK2	1.05404094
21	IKBKB	1.02877053
22	RPS6KA5	1.00444693
23	DAPK3	0.98663786
24	RPS6KL1	0.98333074
25	RPS6KC1	0.98333074
26	GRK1	0.97437634
27	CDK12	0.93193209
28	CHUK	0.92423069
29	RPS6KA2	0.92124364
30	RPS6KA6	0.91872482
31	NME1	0.91528994
32	HIPK2	0.91476301
33	BRD4	0.89690071
34	MAP3K6	0.89578432
35	AURKA	0.87590727
36	PIK3CA	0.86871105
37	STK4	0.84315677
38	MET	0.78297952
39	MELK	0.77743996
40	SGK223	0.72691463
41	SGK494	0.72691463
42	DDR2	0.67513905
43	SGK3	0.67115086
44	CSF1R	0.67018291
45	TGFBR2	0.66681521
46	CAMK2B	0.64812027
47	ERBB2	0.64378251
48	CDK9	0.58895357
49	MST4	0.57782925
50	PKN1	0.57722018
51	MTOR	0.56960838
52	TIE1	0.56645164
53	EIF2AK1	0.55376837
54	PRKAA1	0.54743166
55	PDGFRB	0.53384313
56	NEK6	0.51985900
57	LMTK2	0.50455527
58	EPHA3	0.47554090
59	BRSK1	0.47290662
60	RPS6KB1	0.46039790
61	STK11	0.45710950
62	AURKB	0.45548308
63	LATS2	0.45076385
64	BMPR1B	0.44928418
65	CDC42BPA	0.43494409
66	MAPK1	0.41197171
67	RPS6KA1	0.40621880
68	FRK	0.39893200
69	MAP2K7	0.38882173
70	ABL2	0.38879845
71	ROCK1	0.37278825
72	TAOK3	0.35093584
73	SYK	0.31669085
74	MAPK4	0.31053395
75	MAPK8	0.29776300
76	MAPKAPK5	0.29230341
77	CAMK2D	0.29111319
78	GRK7	0.27514982
79	AKT3	0.26333765
80	INSRR	0.26281609
81	NLK	0.26164182
82	PIM1	0.26150377
83	STK38	0.25346353
84	SGK1	0.25312469
85	PRPF4B	0.22134078
86	MATK	0.21901938
87	TRPM7	0.21225838
88	MAPK3	0.20210949
89	PHKG2	0.18155324
90	PHKG1	0.18155324
91	IGF1R	0.18000373
92	MARK2	0.17709952
93	CAMK2G	0.17220145
94	PKN2	0.16623653
95	PRKCZ	0.16484996
96	EGFR	0.15945213
97	RPS6KA3	0.12982181
98	INSR	0.12862922
99	HCK	0.12009421
100	ABL1	0.11819251

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	8.30829500
2	Alcoholism_Homo sapiens_hsa05034	5.52190005
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.10072964
4	Viral carcinogenesis_Homo sapiens_hsa05203	2.64980638
5	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.34077120
6	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.84042588
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.59206210
8	Melanoma_Homo sapiens_hsa05218	1.44942653
9	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.44346264
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.43403774
11	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.33303687
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25966918
13	Other glycan degradation_Homo sapiens_hsa00511	1.24385828
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14143778
15	MicroRNAs in cancer_Homo sapiens_hsa05206	1.08720109
16	mTOR signaling pathway_Homo sapiens_hsa04150	1.07575989
17	Type II diabetes mellitus_Homo sapiens_hsa04930	1.04805229
18	ABC transporters_Homo sapiens_hsa02010	1.01880489
19	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.01202417
20	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.00695234
21	Prolactin signaling pathway_Homo sapiens_hsa04917	0.98624871
22	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.97197621
23	Selenocompound metabolism_Homo sapiens_hsa00450	0.96449917
24	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.94800402
25	Influenza A_Homo sapiens_hsa05164	0.92568094
26	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.91177865
27	Cholinergic synapse_Homo sapiens_hsa04725	0.90654880
28	Small cell lung cancer_Homo sapiens_hsa05222	0.89757384
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88792934
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.88157120
31	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.87597157
32	Salivary secretion_Homo sapiens_hsa04970	0.85491883
33	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.85033919
34	Morphine addiction_Homo sapiens_hsa05032	0.83995725
35	TNF signaling pathway_Homo sapiens_hsa04668	0.83216579
36	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.81927320
37	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.79484262
38	Insulin resistance_Homo sapiens_hsa04931	0.78573687
39	Axon guidance_Homo sapiens_hsa04360	0.75249561
40	Basal cell carcinoma_Homo sapiens_hsa05217	0.74924826
41	Rap1 signaling pathway_Homo sapiens_hsa04015	0.73960465
42	Circadian rhythm_Homo sapiens_hsa04710	0.72959670
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70034300
44	Lysine degradation_Homo sapiens_hsa00310	0.69132100
45	Nicotine addiction_Homo sapiens_hsa05033	0.68184429
46	Ribosome_Homo sapiens_hsa03010	0.65693084
47	Ras signaling pathway_Homo sapiens_hsa04014	0.64734222
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.64684109
49	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.64238783
50	Choline metabolism in cancer_Homo sapiens_hsa05231	0.64014578
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62407392
52	Homologous recombination_Homo sapiens_hsa03440	0.61895155
53	MAPK signaling pathway_Homo sapiens_hsa04010	0.61672768
54	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.60858908
55	Pathways in cancer_Homo sapiens_hsa05200	0.60427075
56	Hippo signaling pathway_Homo sapiens_hsa04390	0.60093648
57	Gap junction_Homo sapiens_hsa04540	0.59682148
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58604617
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.58471681
60	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.58431059
61	ErbB signaling pathway_Homo sapiens_hsa04012	0.57487700
62	Taste transduction_Homo sapiens_hsa04742	0.56869173
63	Basal transcription factors_Homo sapiens_hsa03022	0.56439671
64	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.56433101
65	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.53765817
66	Apoptosis_Homo sapiens_hsa04210	0.53618387
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52373621
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.52229073
69	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.52199941
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50151936
71	Hepatitis C_Homo sapiens_hsa05160	0.49930461
72	HTLV-I infection_Homo sapiens_hsa05166	0.49360421
73	Olfactory transduction_Homo sapiens_hsa04740	0.49100721
74	Measles_Homo sapiens_hsa05162	0.47990620
75	Osteoclast differentiation_Homo sapiens_hsa04380	0.47881112
76	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.46821092
77	Herpes simplex infection_Homo sapiens_hsa05168	0.44835025
78	Bile secretion_Homo sapiens_hsa04976	0.44622871
79	Adherens junction_Homo sapiens_hsa04520	0.42251423
80	ECM-receptor interaction_Homo sapiens_hsa04512	0.41626937
81	Acute myeloid leukemia_Homo sapiens_hsa05221	0.41074551
82	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.40379962
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.40015033
84	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.39350823
85	Melanogenesis_Homo sapiens_hsa04916	0.37233375
86	Estrogen signaling pathway_Homo sapiens_hsa04915	0.37079143
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.37044172
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36520393
89	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.36419702
90	Renal cell carcinoma_Homo sapiens_hsa05211	0.36311029
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.35025848
92	FoxO signaling pathway_Homo sapiens_hsa04068	0.34821576
93	Gastric acid secretion_Homo sapiens_hsa04971	0.33309651
94	GABAergic synapse_Homo sapiens_hsa04727	0.33177833
95	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.33104603
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32817545
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32453661
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.32061647
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.31658727
100	Circadian entrainment_Homo sapiens_hsa04713	0.31584096

SETP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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