ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA strand renaturation (GO:0000733)	6.23029516
2	translesion synthesis (GO:0019985)	5.01203231
3	DNA replication-dependent nucleosome organization (GO:0034723)	4.78213736
4	DNA replication-dependent nucleosome assembly (GO:0006335)	4.78213736
5	DNA double-strand break processing (GO:0000729)	4.69408096
6	histone H2A acetylation (GO:0043968)	4.67482805
7	chromatin remodeling at centromere (GO:0031055)	4.58015850
8	CENP-A containing nucleosome assembly (GO:0034080)	4.40347798
9	centriole replication (GO:0007099)	4.14805293
10	protein heterotetramerization (GO:0051290)	4.08264982
11	postreplication repair (GO:0006301)	4.08074361
12	regulation of DNA endoreduplication (GO:0032875)	3.96508346
13	intraciliary transport (GO:0042073)	3.93943143
14	ether lipid metabolic process (GO:0046485)	3.79164794
15	rRNA methylation (GO:0031167)	3.71929445
16	histone exchange (GO:0043486)	3.70485303
17	synapsis (GO:0007129)	3.64144714
18	double-strand break repair via homologous recombination (GO:0000724)	3.62291551
19	lactate metabolic process (GO:0006089)	3.59321434
20	recombinational repair (GO:0000725)	3.58310341
21	DNA strand elongation involved in DNA replication (GO:0006271)	3.56866002
22	DNA replication-independent nucleosome assembly (GO:0006336)	3.53559013
23	DNA replication-independent nucleosome organization (GO:0034724)	3.53559013
24	replication fork processing (GO:0031297)	3.50222786
25	DNA strand elongation (GO:0022616)	3.39419549
26	telomere maintenance via semi-conservative replication (GO:0032201)	3.37533981
27	rRNA modification (GO:0000154)	3.29905374
28	telomere maintenance via recombination (GO:0000722)	3.29416095
29	ribosome assembly (GO:0042255)	3.28837307
30	non-recombinational repair (GO:0000726)	3.24712783
31	double-strand break repair via nonhomologous end joining (GO:0006303)	3.24712783
32	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.24247021
33	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.24247021
34	resolution of meiotic recombination intermediates (GO:0000712)	3.23739947
35	protein localization to kinetochore (GO:0034501)	3.19670487
36	DNA catabolic process, exonucleolytic (GO:0000738)	3.13799570
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.13026846
38	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09884529
39	DNA replication checkpoint (GO:0000076)	3.09704811
40	alternative mRNA splicing, via spliceosome (GO:0000380)	3.09529297
41	forebrain morphogenesis (GO:0048853)	3.07114962
42	cullin deneddylation (GO:0010388)	2.97602355
43	protein localization to cilium (GO:0061512)	2.97448999
44	mitotic recombination (GO:0006312)	2.97446165
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97216854
46	double-strand break repair (GO:0006302)	2.96613865
47	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.92603061
48	base-excision repair, AP site formation (GO:0006285)	2.91171603
49	nonmotile primary cilium assembly (GO:0035058)	2.90216141
50	negative regulation of axon guidance (GO:1902668)	2.88678790
51	deoxyribonucleotide biosynthetic process (GO:0009263)	2.83634854
52	regulation of helicase activity (GO:0051095)	2.82726742
53	negative regulation of DNA recombination (GO:0045910)	2.78689587
54	positive regulation of RNA splicing (GO:0033120)	2.78430856
55	positive regulation of male gonad development (GO:2000020)	2.78293606
56	centriole assembly (GO:0098534)	2.78161969
57	cilium assembly (GO:0042384)	2.75695021
58	cilium organization (GO:0044782)	2.73900504
59	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.73870130
60	smoothened signaling pathway (GO:0007224)	2.72082822
61	lateral ventricle development (GO:0021670)	2.69055641
62	response to X-ray (GO:0010165)	2.67864175
63	attachment of spindle microtubules to kinetochore (GO:0008608)	2.67595604
64	protein K11-linked ubiquitination (GO:0070979)	2.65437297
65	pseudouridine synthesis (GO:0001522)	2.63133356
66	protein neddylation (GO:0045116)	2.62110251
67	protein deneddylation (GO:0000338)	2.61170545
68	DNA recombination (GO:0006310)	2.59575262
69	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.59357619
70	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.59357619
71	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.59357619
72	DNA replication initiation (GO:0006270)	2.59098620
73	spindle checkpoint (GO:0031577)	2.58832716
74	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.58358973
75	regulation of mitotic spindle checkpoint (GO:1903504)	2.58358973
76	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.58354026
77	IMP biosynthetic process (GO:0006188)	2.57168455
78	mRNA splice site selection (GO:0006376)	2.56854926
79	mitotic sister chromatid segregation (GO:0000070)	2.56218566
80	epithelial cell differentiation involved in kidney development (GO:0035850)	2.55694729
81	telomere maintenance (GO:0000723)	2.54747549
82	cornea development in camera-type eye (GO:0061303)	2.53480093
83	single strand break repair (GO:0000012)	2.51572909
84	C4-dicarboxylate transport (GO:0015740)	2.51441796
85	kinetochore assembly (GO:0051382)	2.51299886
86	chromatin assembly or disassembly (GO:0006333)	2.50415371
87	L-serine metabolic process (GO:0006563)	2.49163079
88	microtubule polymerization or depolymerization (GO:0031109)	2.48374021
89	prenylation (GO:0097354)	2.48238502
90	protein prenylation (GO:0018342)	2.48238502
91	histone H2A ubiquitination (GO:0033522)	2.47967403
92	glycerol ether metabolic process (GO:0006662)	2.47908448
93	purine nucleobase biosynthetic process (GO:0009113)	2.47577736
94	regulation of sister chromatid cohesion (GO:0007063)	2.47390736
95	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.46912877
96	telomere organization (GO:0032200)	2.46904185
97	branched-chain amino acid catabolic process (GO:0009083)	2.46879421
98	centrosome organization (GO:0051297)	2.46740402
99	telomere maintenance via telomere lengthening (GO:0010833)	2.46194154
100	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.45263860

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.17990095
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.92845675
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.57354720
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.30671992
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.94910700
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.74688163
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.71712807
8	FUS_26573619_Chip-Seq_HEK293_Human	2.65728926
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.62278530
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.56048661
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.50945014
12	VDR_22108803_ChIP-Seq_LS180_Human	2.44193931
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25092895
14	EWS_26573619_Chip-Seq_HEK293_Human	2.21347391
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.17564990
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.14599887
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.11377477
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.06796502
19	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.84590855
20	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.83593084
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.82726543
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.80515708
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.79834896
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76258711
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72712372
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.70049859
27	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.67416333
28	P300_19829295_ChIP-Seq_ESCs_Human	1.66541765
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63881822
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.62072018
31	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.60722318
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60542748
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.60323839
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59278176
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53865260
36	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.51647683
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46451307
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.46065587
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43058038
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.41082082
41	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.40687052
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.39547444
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39371814
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38358326
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38164140
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34262733
47	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.31767571
48	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31623780
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.31564924
50	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.31106756
51	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.27563700
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27302677
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.26488633
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26393756
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25748319
56	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.23655036
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23477592
58	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.23141999
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.22427136
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20667395
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18608318
62	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16294178
63	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.16013082
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.14827496
65	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.13205308
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12418499
67	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10927841
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10911387
69	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10066718
70	TTF2_22483619_ChIP-Seq_HELA_Human	1.09684554
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09601607
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08770923
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08748758
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07276581
75	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.06674029
76	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05667039
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04269431
78	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.03917359
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.02743492
80	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01645666
81	AR_25329375_ChIP-Seq_VCAP_Human	1.00855932
82	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00494421
83	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99493097
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96789221
85	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96505990
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.96478641
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96278121
88	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96190403
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95894810
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95849003
91	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.94428033
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93984512
93	TCF4_23295773_ChIP-Seq_U87_Human	0.93941185
94	TCF4_22108803_ChIP-Seq_LS180_Human	0.93893981
95	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.93780979
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.93344385
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93263579
98	TP53_22573176_ChIP-Seq_HFKS_Human	0.92428213
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91131805
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91131805

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.87817229
2	MP0008057_abnormal_DNA_replication	3.55588366
3	MP0010094_abnormal_chromosome_stability	3.37558582
4	MP0008058_abnormal_DNA_repair	3.11869287
5	MP0001346_abnormal_lacrimal_gland	2.87266463
6	MP0002163_abnormal_gland_morphology	2.84970217
7	MP0001529_abnormal_vocalization	2.81844758
8	MP0002938_white_spotting	2.81088528
9	MP0006054_spinal_hemorrhage	2.73121499
10	MP0002234_abnormal_pharynx_morphology	2.71746673
11	MP0003880_abnormal_central_pattern	2.60892753
12	MP0009697_abnormal_copulation	2.54372446
13	MP0002876_abnormal_thyroid_physiology	2.33921364
14	MP0005379_endocrine/exocrine_gland_phen	2.26228757
15	MP0002638_abnormal_pupillary_reflex	2.04531406
16	MP0006276_abnormal_autonomic_nervous	1.98978477
17	MP0001348_abnormal_lacrimal_gland	1.94435567
18	MP0003123_paternal_imprinting	1.89902043
19	MP0001293_anophthalmia	1.84135913
20	MP0003718_maternal_effect	1.83642225
21	MP0005551_abnormal_eye_electrophysiolog	1.79523940
22	MP0003111_abnormal_nucleus_morphology	1.77429346
23	MP0000372_irregular_coat_pigmentation	1.68881856
24	MP0008877_abnormal_DNA_methylation	1.65950553
25	MP0009278_abnormal_bone_marrow	1.56232979
26	MP0005084_abnormal_gallbladder_morpholo	1.55635472
27	MP0003121_genomic_imprinting	1.55010450
28	MP0002282_abnormal_trachea_morphology	1.54942947
29	MP0002160_abnormal_reproductive_system	1.51123997
30	MP0001764_abnormal_homeostasis	1.48825004
31	MP0002736_abnormal_nociception_after	1.39538068
32	MP0006072_abnormal_retinal_apoptosis	1.39444043
33	MP0003077_abnormal_cell_cycle	1.36327118
34	MP0003943_abnormal_hepatobiliary_system	1.35062539
35	MP0003786_premature_aging	1.34163929
36	MP0008875_abnormal_xenobiotic_pharmacok	1.31098203
37	MP0005167_abnormal_blood-brain_barrier	1.30326255
38	MP0004957_abnormal_blastocyst_morpholog	1.27496472
39	MP0005310_abnormal_salivary_gland	1.27301128
40	MP0000631_abnormal_neuroendocrine_gland	1.26261233
41	MP0006035_abnormal_mitochondrial_morpho	1.23387837
42	MP0003567_abnormal_fetal_cardiomyocyte	1.18479254
43	MP0008932_abnormal_embryonic_tissue	1.17361324
44	MP0000383_abnormal_hair_follicle	1.16599489
45	MP0000778_abnormal_nervous_system	1.16356621
46	MP0005253_abnormal_eye_physiology	1.15046356
47	MP0001929_abnormal_gametogenesis	1.09600365
48	MP0004147_increased_porphyrin_level	1.08631316
49	MP0000358_abnormal_cell_content/	1.06592118
50	MP0004043_abnormal_pH_regulation	1.05067802
51	MP0002697_abnormal_eye_size	1.04641181
52	MP0006036_abnormal_mitochondrial_physio	1.04513267
53	MP0002928_abnormal_bile_duct	1.03851759
54	MP0005389_reproductive_system_phenotype	1.03203198
55	MP0001968_abnormal_touch/_nociception	1.03134334
56	MP0005187_abnormal_penis_morphology	1.01171525
57	MP0005391_vision/eye_phenotype	1.00534203
58	MP0003698_abnormal_male_reproductive	0.99817052
59	MP0003136_yellow_coat_color	0.96536677
60	MP0000653_abnormal_sex_gland	0.96056373
61	MP0005645_abnormal_hypothalamus_physiol	0.95151183
62	MP0001119_abnormal_female_reproductive	0.94970355
63	MP0002751_abnormal_autonomic_nervous	0.94745515
64	MP0006082_CNS_inflammation	0.92668352
65	MP0003693_abnormal_embryo_hatching	0.92054563
66	MP0004782_abnormal_surfactant_physiolog	0.91873289
67	MP0001286_abnormal_eye_development	0.87507655
68	MP0001177_atelectasis	0.86165168
69	MP0008872_abnormal_physiological_respon	0.84676639
70	MP0000647_abnormal_sebaceous_gland	0.84427849
71	MP0000049_abnormal_middle_ear	0.84426853
72	MP0008007_abnormal_cellular_replicative	0.83868085
73	MP0002090_abnormal_vision	0.82474285
74	MP0010678_abnormal_skin_adnexa	0.82432283
75	MP0005195_abnormal_posterior_eye	0.81846420
76	MP0005410_abnormal_fertilization	0.80949804
77	MP0001697_abnormal_embryo_size	0.80464657
78	MP0001145_abnormal_male_reproductive	0.79121019
79	MP0002210_abnormal_sex_determination	0.78949385
80	MP0009745_abnormal_behavioral_response	0.78749334
81	MP0008789_abnormal_olfactory_epithelium	0.77755444
82	MP0001486_abnormal_startle_reflex	0.77668791
83	MP0004133_heterotaxia	0.75098169
84	MP0009046_muscle_twitch	0.73680746
85	MP0002102_abnormal_ear_morphology	0.73501627
86	MP0002822_catalepsy	0.71709703
87	MP0004215_abnormal_myocardial_fiber	0.70673807
88	MP0005647_abnormal_sex_gland	0.68270262
89	MP0001188_hyperpigmentation	0.68175109
90	MP0004142_abnormal_muscle_tone	0.67333387
91	MP0001324_abnormal_eye_pigmentation	0.66308272
92	MP0004808_abnormal_hematopoietic_stem	0.66099126
93	MP0002092_abnormal_eye_morphology	0.64926703
94	MP0003195_calcinosis	0.64048930
95	MP0003937_abnormal_limbs/digits/tail_de	0.63287905
96	MP0004924_abnormal_behavior	0.62919008
97	MP0005386_behavior/neurological_phenoty	0.62919008
98	MP0003861_abnormal_nervous_system	0.62916892
99	MP0008775_abnormal_heart_ventricle	0.62856279
100	MP0002752_abnormal_somatic_nervous	0.60943698

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.91199318
2	Pancreatic fibrosis (HP:0100732)	3.86026488
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.70286494
4	Abnormality of the labia minora (HP:0012880)	3.46607805
5	Abnormality of the preputium (HP:0100587)	3.42364327
6	Abnormality of chromosome stability (HP:0003220)	3.29625946
7	Chromsome breakage (HP:0040012)	3.24739103
8	Pancreatic cysts (HP:0001737)	3.17217860
9	Volvulus (HP:0002580)	3.11560010
10	Abnormality of the ileum (HP:0001549)	3.08592572
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.06039586
12	Meckel diverticulum (HP:0002245)	3.02995923
13	Abnormality of macular pigmentation (HP:0008002)	3.01089192
14	Pancreatic islet-cell hyperplasia (HP:0004510)	2.91928544
15	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.86714749
16	Sloping forehead (HP:0000340)	2.84014214
17	Sclerocornea (HP:0000647)	2.82717037
18	Hypoplastic pelvis (HP:0008839)	2.82330117
19	Nephronophthisis (HP:0000090)	2.74554560
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.70868774
21	Hyperglycinemia (HP:0002154)	2.66330681
22	Molar tooth sign on MRI (HP:0002419)	2.66234158
23	Abnormality of midbrain morphology (HP:0002418)	2.66234158
24	Cystic liver disease (HP:0006706)	2.64480195
25	Decreased central vision (HP:0007663)	2.53340625
26	Conjugated hyperbilirubinemia (HP:0002908)	2.48461889
27	Oligodactyly (hands) (HP:0001180)	2.46138145
28	Facial hemangioma (HP:0000329)	2.43375196
29	Abnormality of endocrine pancreas physiology (HP:0012093)	2.39550728
30	Abnormality of the pancreatic islet cells (HP:0006476)	2.39550728
31	Nephrogenic diabetes insipidus (HP:0009806)	2.38954620
32	Autoimmune thrombocytopenia (HP:0001973)	2.38881279
33	Type II lissencephaly (HP:0007260)	2.35892106
34	Congenital hepatic fibrosis (HP:0002612)	2.32370378
35	Methylmalonic acidemia (HP:0002912)	2.29653285
36	Abnormality of the renal medulla (HP:0100957)	2.28270305
37	Carpal bone hypoplasia (HP:0001498)	2.27395311
38	Cerebellar dysplasia (HP:0007033)	2.27308920
39	Lissencephaly (HP:0001339)	2.25949740
40	Colon cancer (HP:0003003)	2.23150140
41	Abnormality of DNA repair (HP:0003254)	2.22831620
42	Limb hypertonia (HP:0002509)	2.21864313
43	Male pseudohermaphroditism (HP:0000037)	2.21278674
44	Broad distal phalanx of finger (HP:0009836)	2.21115363
45	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.20154028
46	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.15332193
47	Absent/shortened dynein arms (HP:0200106)	2.15332193
48	Tubulointerstitial abnormality (HP:0001969)	2.15029996
49	Optic nerve hypoplasia (HP:0000609)	2.14802518
50	Postaxial foot polydactyly (HP:0001830)	2.11710840
51	Oligodactyly (HP:0012165)	2.11079243
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.08053478
53	Small intestinal stenosis (HP:0012848)	2.05867958
54	Duodenal stenosis (HP:0100867)	2.05867958
55	Oligohydramnios (HP:0001562)	2.04041111
56	Triphalangeal thumb (HP:0001199)	2.03198477
57	Tubulointerstitial nephritis (HP:0001970)	2.02764573
58	Ectopic kidney (HP:0000086)	2.01013928
59	Abnormality of lateral ventricle (HP:0030047)	1.98709660
60	Attenuation of retinal blood vessels (HP:0007843)	1.97559311
61	Retinal dysplasia (HP:0007973)	1.96734355
62	Abnormality of the carotid arteries (HP:0005344)	1.96452977
63	Tubulointerstitial fibrosis (HP:0005576)	1.92123020
64	Clubbing of toes (HP:0100760)	1.90068379
65	Abnormal lung lobation (HP:0002101)	1.89858861
66	Bifid scrotum (HP:0000048)	1.89417342
67	Constricted visual fields (HP:0001133)	1.88922886
68	Abnormality of the duodenum (HP:0002246)	1.87660480
69	Myelodysplasia (HP:0002863)	1.87040189
70	Hypoplasia of the pons (HP:0012110)	1.86793386
71	Acute encephalopathy (HP:0006846)	1.86537985
72	Acute necrotizing encephalopathy (HP:0006965)	1.86487674
73	Irregular epiphyses (HP:0010582)	1.85827321
74	Supernumerary spleens (HP:0009799)	1.85601279
75	Cerebral edema (HP:0002181)	1.85354322
76	Central scotoma (HP:0000603)	1.82533775
77	Dandy-Walker malformation (HP:0001305)	1.82276534
78	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80257757
79	Patellar aplasia (HP:0006443)	1.79589271
80	Pendular nystagmus (HP:0012043)	1.79184008
81	Hip dysplasia (HP:0001385)	1.79172158
82	Increased CSF lactate (HP:0002490)	1.77642893
83	Abnormality of methionine metabolism (HP:0010901)	1.77280406
84	Abnormal sex determination (HP:0012244)	1.76612486
85	Sex reversal (HP:0012245)	1.76612486
86	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76202393
87	Medial flaring of the eyebrow (HP:0010747)	1.75850965
88	Anencephaly (HP:0002323)	1.75255446
89	Thyroiditis (HP:0100646)	1.74894337
90	Methylmalonic aciduria (HP:0012120)	1.74856597
91	Absent thumb (HP:0009777)	1.74148968
92	Absent forearm bone (HP:0003953)	1.73970528
93	Aplasia involving forearm bones (HP:0009822)	1.73970528
94	Eosinophilia (HP:0001880)	1.73911704
95	Scotoma (HP:0000575)	1.73165851
96	Preaxial hand polydactyly (HP:0001177)	1.71585577
97	Hepatocellular necrosis (HP:0001404)	1.71075263
98	Asplenia (HP:0001746)	1.70512577
99	Stenosis of the external auditory canal (HP:0000402)	1.70207589
100	Renal hypoplasia (HP:0000089)	1.69563032

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	5.18185114
2	BCR	5.07584163
3	EPHA3	3.29321494
4	EIF2AK3	2.98115085
5	VRK2	2.64256207
6	TNIK	2.47775778
7	PNCK	2.43454376
8	VRK1	2.36593418
9	WEE1	2.32500856
10	CASK	2.12720640
11	NEK1	2.06998201
12	WNK3	2.06841012
13	PLK2	1.98343821
14	FRK	1.92801841
15	TAF1	1.92688823
16	MKNK1	1.88867941
17	BUB1	1.88675652
18	BRSK2	1.85603787
19	ZAK	1.82964265
20	SIK3	1.80238340
21	NUAK1	1.76706111
22	MKNK2	1.69349977
23	BMPR1B	1.63200483
24	PLK4	1.58238691
25	PLK3	1.53567388
26	BCKDK	1.49199423
27	TSSK6	1.29094752
28	MAPK13	1.28021036
29	MAP2K7	1.27222354
30	TTK	1.25621178
31	OXSR1	1.23123783
32	MAP3K4	1.21682058
33	MINK1	1.16203614
34	PLK1	1.15520983
35	CDC7	1.08656630
36	ACVR1B	1.07925167
37	WNK4	1.06452646
38	INSRR	1.06124608
39	STK39	1.04584005
40	BRD4	1.01425807
41	CSNK1G3	0.99322509
42	TLK1	0.99306877
43	STK3	0.98426563
44	CSNK1G2	0.96676939
45	CSNK1G1	0.94365692
46	ERBB3	0.91711124
47	DYRK3	0.89618520
48	RPS6KA4	0.89438656
49	AURKB	0.83785336
50	SRPK1	0.79090666
51	DYRK1A	0.77412081
52	MAP3K3	0.77274070
53	STK38L	0.75319602
54	CCNB1	0.74354205
55	ATR	0.73902370
56	FER	0.71861958
57	PRKD3	0.68372842
58	FGFR1	0.67695570
59	DYRK2	0.66858682
60	ATM	0.64694487
61	UHMK1	0.64311558
62	TAOK1	0.63014418
63	EIF2AK1	0.63003455
64	EIF2AK2	0.62892978
65	FGFR2	0.62669560
66	CSNK1A1L	0.61679813
67	CHEK1	0.58401246
68	BRSK1	0.57615750
69	TGFBR1	0.57524621
70	NME1	0.56328399
71	GRK1	0.54751321
72	EPHB2	0.53457524
73	CHEK2	0.52961793
74	NEK2	0.50595965
75	PASK	0.49862964
76	DYRK1B	0.47597709
77	NEK9	0.45294228
78	PIK3CG	0.45058292
79	STK4	0.44676371
80	CDK18	0.44475711
81	MARK1	0.41624800
82	EPHA4	0.39421113
83	CDK3	0.36071034
84	RPS6KA5	0.35839756
85	PRKCE	0.35406377
86	MET	0.34915555
87	PKN1	0.33690826
88	PBK	0.33618387
89	CSNK1A1	0.32686149
90	CDK15	0.32156570
91	MAP4K2	0.29746538
92	CDK19	0.27222523
93	CDK14	0.26301074
94	CDK11A	0.25341909
95	GSK3A	0.24335364
96	MAP2K4	0.24254802
97	PRKAA1	0.24159027
98	CDK1	0.23756419
99	ADRBK2	0.23606413
100	MAP2K6	0.23215153

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.80155773
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.59102597
3	DNA replication_Homo sapiens_hsa03030	3.06072804
4	Homologous recombination_Homo sapiens_hsa03440	3.05376884
5	Mismatch repair_Homo sapiens_hsa03430	2.75927738
6	Propanoate metabolism_Homo sapiens_hsa00640	2.51623179
7	Spliceosome_Homo sapiens_hsa03040	2.29028360
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.20513052
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.13941479
10	RNA degradation_Homo sapiens_hsa03018	2.11330285
11	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.06860566
12	Protein export_Homo sapiens_hsa03060	2.06013034
13	Base excision repair_Homo sapiens_hsa03410	1.99115728
14	Basal transcription factors_Homo sapiens_hsa03022	1.91291907
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.91057621
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70885715
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.69038644
18	Caffeine metabolism_Homo sapiens_hsa00232	1.69008714
19	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.68241177
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.63551227
21	RNA transport_Homo sapiens_hsa03013	1.59509416
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.59050134
23	Phototransduction_Homo sapiens_hsa04744	1.58848964
24	RNA polymerase_Homo sapiens_hsa03020	1.56850546
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.56280903
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.55151859
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.49946930
28	Cell cycle_Homo sapiens_hsa04110	1.49345285
29	Alcoholism_Homo sapiens_hsa05034	1.46787579
30	Butanoate metabolism_Homo sapiens_hsa00650	1.43884652
31	p53 signaling pathway_Homo sapiens_hsa04115	1.33302525
32	Glutathione metabolism_Homo sapiens_hsa00480	1.28881620
33	One carbon pool by folate_Homo sapiens_hsa00670	1.28478987
34	Nicotine addiction_Homo sapiens_hsa05033	1.21286577
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.20110922
36	Purine metabolism_Homo sapiens_hsa00230	1.18995676
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.17577264
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.15897649
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.14637015
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.10284379
41	Proteasome_Homo sapiens_hsa03050	1.08816972
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.97943671
43	Olfactory transduction_Homo sapiens_hsa04740	0.97553206
44	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.95539601
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94938899
46	Peroxisome_Homo sapiens_hsa04146	0.94712194
47	Oocyte meiosis_Homo sapiens_hsa04114	0.90688511
48	Basal cell carcinoma_Homo sapiens_hsa05217	0.90635426
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.88801704
50	Huntingtons disease_Homo sapiens_hsa05016	0.85048657
51	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.84427229
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83105395
53	Parkinsons disease_Homo sapiens_hsa05012	0.80838686
54	Cocaine addiction_Homo sapiens_hsa05030	0.80666451
55	Oxidative phosphorylation_Homo sapiens_hsa00190	0.80422063
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.77238519
57	Lysine degradation_Homo sapiens_hsa00310	0.77039937
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76356332
59	Fatty acid degradation_Homo sapiens_hsa00071	0.73709560
60	Circadian rhythm_Homo sapiens_hsa04710	0.72778755
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.71859144
62	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.68515442
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67835046
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67310222
65	Carbon metabolism_Homo sapiens_hsa01200	0.66851958
66	African trypanosomiasis_Homo sapiens_hsa05143	0.64462219
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.63596289
68	Metabolic pathways_Homo sapiens_hsa01100	0.62489337
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61856042
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59881689
71	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.58986688
72	Fatty acid elongation_Homo sapiens_hsa00062	0.57974230
73	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.57482565
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57185545
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.57038146
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.55471369
77	Alzheimers disease_Homo sapiens_hsa05010	0.52907341
78	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52834177
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51881666
80	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.49736341
81	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.48826233
82	GABAergic synapse_Homo sapiens_hsa04727	0.46992047
83	Regulation of autophagy_Homo sapiens_hsa04140	0.41667745
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41621819
85	Renin-angiotensin system_Homo sapiens_hsa04614	0.41217345
86	Viral carcinogenesis_Homo sapiens_hsa05203	0.39953904
87	Insulin secretion_Homo sapiens_hsa04911	0.39258978
88	Melanogenesis_Homo sapiens_hsa04916	0.38730986
89	Morphine addiction_Homo sapiens_hsa05032	0.38092233
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38087667
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37981656
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37506150
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.37451593
94	Serotonergic synapse_Homo sapiens_hsa04726	0.37168961
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36556243
96	Circadian entrainment_Homo sapiens_hsa04713	0.34895772
97	Hippo signaling pathway_Homo sapiens_hsa04390	0.34731726
98	Amphetamine addiction_Homo sapiens_hsa05031	0.34339878
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.33799240
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31645155

SETP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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