SETP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucose import in response to insulin stimulus (GO:2001273)6.81011804
2negative regulation of glucose import (GO:0046325)6.56888126
3negative regulation of glucose transport (GO:0010829)6.33683711
4positive regulation of gamma-delta T cell activation (GO:0046645)5.82457705
5NIK/NF-kappaB signaling (GO:0038061)5.30393042
6interleukin-6-mediated signaling pathway (GO:0070102)4.83641680
7cellular response to ethanol (GO:0071361)4.66717924
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.64726981
9negative regulation of cell killing (GO:0031342)4.64726981
10regulation of B cell receptor signaling pathway (GO:0050855)4.38965721
11regulation of gamma-delta T cell activation (GO:0046643)4.28577574
12mannose metabolic process (GO:0006013)4.23034240
13negative regulation of interleukin-12 production (GO:0032695)4.22758078
14B cell receptor signaling pathway (GO:0050853)4.20370489
15regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.14011872
16natural killer cell activation involved in immune response (GO:0002323)4.10234372
17regulation of MHC class I biosynthetic process (GO:0045343)4.01379983
18natural killer cell differentiation (GO:0001779)3.94535256
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.94369219
20ER overload response (GO:0006983)3.82643555
21regulation of B cell differentiation (GO:0045577)3.80417243
22regulation of B cell proliferation (GO:0030888)3.76610117
23histone H3-K4 trimethylation (GO:0080182)3.73694635
24B cell proliferation (GO:0042100)3.70033320
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.68165967
26modulation by symbiont of host immune response (GO:0052553)3.68165967
27positive regulation by symbiont of host defense response (GO:0052509)3.68165967
28modulation by symbiont of host defense response (GO:0052031)3.68165967
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68165967
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68165967
31negative regulation of T cell mediated immunity (GO:0002710)3.67258771
32positive regulation of B cell differentiation (GO:0045579)3.64723209
33cellular extravasation (GO:0045123)3.63454372
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.62071682
35type I interferon signaling pathway (GO:0060337)3.60869580
36cellular response to type I interferon (GO:0071357)3.60869580
37response to type I interferon (GO:0034340)3.57389834
38negative regulation of cellular response to insulin stimulus (GO:1900077)3.57158034
39embryonic process involved in female pregnancy (GO:0060136)3.55955196
40T cell homeostasis (GO:0043029)3.55120547
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54826516
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51740038
43positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.48890147
44regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.48890147
45interferon-gamma production (GO:0032609)3.48561329
46positive regulation of protein homooligomerization (GO:0032464)3.48062913
47T cell migration (GO:0072678)3.47038036
48respiratory burst (GO:0045730)3.44187360
49B cell homeostasis (GO:0001782)3.36834120
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36757430
51antigen processing and presentation of endogenous antigen (GO:0019883)3.34060754
52GDP-mannose metabolic process (GO:0019673)3.30967350
53positive T cell selection (GO:0043368)3.27949762
54regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.26912705
55immunoglobulin mediated immune response (GO:0016064)3.23478591
56detection of molecule of bacterial origin (GO:0032490)3.22855511
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18717391
58regulation of T cell mediated cytotoxicity (GO:0001914)3.18178094
59leukocyte aggregation (GO:0070486)3.18165817
60positive regulation of immunoglobulin production (GO:0002639)3.14231827
61negative thymic T cell selection (GO:0045060)3.13595333
62negative regulation of lymphocyte mediated immunity (GO:0002707)3.12202855
63natural killer cell activation (GO:0030101)3.12072649
64intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)3.07322797
65positive regulation of defense response to virus by host (GO:0002230)3.05583550
66histone-serine phosphorylation (GO:0035404)3.05489116
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04804428
68negative T cell selection (GO:0043383)3.04779725
69neutrophil activation involved in immune response (GO:0002283)3.04769941
70regulation of cytokine secretion involved in immune response (GO:0002739)3.01690479
71positive thymic T cell selection (GO:0045059)3.01428387
72negative regulation of interleukin-6 production (GO:0032715)3.01215674
73regulation of B cell activation (GO:0050864)2.99720976
74interferon-gamma-mediated signaling pathway (GO:0060333)2.99619097
75regulation of gamma-delta T cell differentiation (GO:0045586)2.98578833
76regulation of fibroblast apoptotic process (GO:2000269)2.98528306
77necroptotic process (GO:0070266)2.96695649
78cellular response to glucose starvation (GO:0042149)2.96183284
79lymphocyte homeostasis (GO:0002260)2.95821436
80macrophage activation involved in immune response (GO:0002281)2.95773002
81regulation of energy homeostasis (GO:2000505)2.95467872
82positive regulation of granulocyte differentiation (GO:0030854)2.94510786
83protein maturation by protein folding (GO:0022417)2.94277209
84lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92670988
85positive regulation of B cell proliferation (GO:0030890)2.91222906
86mast cell activation (GO:0045576)2.89335800
87response to peptidoglycan (GO:0032494)2.87718459
88hepatocyte apoptotic process (GO:0097284)2.87139346
89positive regulation of toll-like receptor signaling pathway (GO:0034123)2.83993480
90B cell mediated immunity (GO:0019724)2.82305154
91regulation of necroptotic process (GO:0060544)2.81899845
92T cell selection (GO:0045058)2.77479324
93T cell activation involved in immune response (GO:0002286)2.77088089
94tolerance induction (GO:0002507)2.76971604
95myeloid cell activation involved in immune response (GO:0002275)2.76071278
96signal peptide processing (GO:0006465)2.75940922
97positive regulation of B cell activation (GO:0050871)2.74620710
98ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.73702675
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73273805
100regulation of T cell migration (GO:2000404)2.73185469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.51919514
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.63537521
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.71459541
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.23441218
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.57424328
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.49215321
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38688772
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28039472
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.20562618
10MYB_26560356_Chip-Seq_TH2_Human3.00546586
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87091819
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86900655
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.81416910
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73987087
15RUNX_20019798_ChIP-Seq_JUKART_Human2.65947604
16MYC_22102868_ChIP-Seq_BL_Human2.64216110
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62070123
18SPI1_23547873_ChIP-Seq_NB4_Human2.52801887
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40135403
20GATA1_22025678_ChIP-Seq_K562_Human2.39229997
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38241249
22MYB_26560356_Chip-Seq_TH1_Human2.34198889
23SCL_19346495_ChIP-Seq_HPC-7_Human2.32386968
24GATA3_27048872_Chip-Seq_THYMUS_Human2.31561016
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31196966
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.17218101
27GATA3_26560356_Chip-Seq_TH2_Human2.11335646
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06271442
29MAF_26560356_Chip-Seq_TH1_Human2.03777591
30NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.97538611
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.89968389
32UTX_26944678_Chip-Seq_JUKART_Human1.82137276
33VDR_24763502_ChIP-Seq_THP-1_Human1.81841169
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.81697685
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80845697
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75860461
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.75493618
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61147578
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.58904874
40VDR_24787735_ChIP-Seq_THP-1_Human1.58726658
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55537967
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54006070
43TFEB_21752829_ChIP-Seq_HELA_Human1.53057418
44SPI1_23127762_ChIP-Seq_K562_Human1.50093606
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48424909
46MAF_26560356_Chip-Seq_TH2_Human1.45603396
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44424235
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42586491
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41880400
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41474370
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38828854
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35562979
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34058607
54PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33964919
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31969763
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29211021
57VDR_21846776_ChIP-Seq_THP-1_Human1.29072683
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28040413
59CIITA_25753668_ChIP-Seq_RAJI_Human1.23521101
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22873368
61IRF1_19129219_ChIP-ChIP_H3396_Human1.21897783
62GATA3_26560356_Chip-Seq_TH1_Human1.19765644
63PU_27001747_Chip-Seq_BMDM_Mouse1.19022473
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18620110
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18121520
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16885795
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14709211
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14709211
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14709211
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13924874
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12209794
72TCF7_22412390_ChIP-Seq_EML_Mouse1.11706503
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11553695
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09337662
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08756513
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03328946
77SMRT_27268052_Chip-Seq_Bcells_Human0.97596467
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95018120
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93628606
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88094310
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87691357
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87614451
83GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87551588
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87115584
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84802419
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84418873
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82952652
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82771021
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82661339
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82282147
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81681689
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80735775
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79764489
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.79657189
95STAT1_20625510_ChIP-Seq_HELA_Human0.79419505
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77522934
97KDM2B_26808549_Chip-Seq_DND41_Human0.77066905
98VDR_23849224_ChIP-Seq_CD4+_Human0.75878395
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.73901213
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73037068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.20473224
2MP0005671_abnormal_response_to4.17900290
3MP0001835_abnormal_antigen_presentation3.73068887
4MP0001800_abnormal_humoral_immune3.57985641
5MP0005000_abnormal_immune_tolerance3.10930654
6MP0003436_decreased_susceptibility_to3.10076648
7MP0000685_abnormal_immune_system3.08474413
8MP0000015_abnormal_ear_pigmentation3.03829844
9MP0002148_abnormal_hypersensitivity_rea2.89655919
10MP0002452_abnormal_antigen_presenting2.83523331
11MP0003724_increased_susceptibility_to2.82979869
12MP0002723_abnormal_immune_serum2.80624075
13MP0005387_immune_system_phenotype2.72821194
14MP0001790_abnormal_immune_system2.72821194
15MP0002420_abnormal_adaptive_immunity2.59665221
16MP0001819_abnormal_immune_cell2.57151026
17MP0003763_abnormal_thymus_physiology2.56035906
18MP0005464_abnormal_platelet_physiology2.48430322
19MP0002419_abnormal_innate_immunity2.45417314
20MP0009785_altered_susceptibility_to2.42570781
21MP0005025_abnormal_response_to2.37410531
22MP0002398_abnormal_bone_marrow2.30681700
23MP0002254_reproductive_system_inflammat2.26878309
24MP0003656_abnormal_erythrocyte_physiolo2.24595633
25MP0000716_abnormal_immune_system2.11145406
26MP0000689_abnormal_spleen_morphology1.94705122
27MP0002138_abnormal_hepatobiliary_system1.84086888
28MP0002722_abnormal_immune_system1.82044018
29MP0008260_abnormal_autophagy1.81216099
30MP0004510_myositis1.79649294
31MP0001845_abnormal_inflammatory_respons1.79294135
32MP0010155_abnormal_intestine_physiology1.74724681
33MP0002277_abnormal_respiratory_mucosa1.73421344
34MP0002429_abnormal_blood_cell1.72026212
35MP0006082_CNS_inflammation1.71895008
36MP0002405_respiratory_system_inflammati1.69575435
37MP0003300_gastrointestinal_ulcer1.67577053
38MP0001873_stomach_inflammation1.65250986
39MP0002653_abnormal_ependyma_morphology1.65150218
40MP0004808_abnormal_hematopoietic_stem1.64653865
41MP0005310_abnormal_salivary_gland1.59153914
42MP0000703_abnormal_thymus_morphology1.58251664
43MP0009333_abnormal_splenocyte_physiolog1.57519565
44MP0001533_abnormal_skeleton_physiology1.57304522
45MP0001545_abnormal_hematopoietic_system1.53532861
46MP0005397_hematopoietic_system_phenotyp1.53532861
47MP0009764_decreased_sensitivity_to1.45663661
48MP0006054_spinal_hemorrhage1.44627344
49MP0002132_abnormal_respiratory_system1.41246114
50MP0004947_skin_inflammation1.38464985
51MP0003045_fibrosis1.36904945
52MP0009278_abnormal_bone_marrow1.35267932
53MP0004130_abnormal_muscle_cell1.24606139
54MP0005075_abnormal_melanosome_morpholog1.24366309
55MP0008469_abnormal_protein_level1.19727092
56MP0004381_abnormal_hair_follicle1.17732535
57MP0003866_abnormal_defecation1.11347308
58MP0004036_abnormal_muscle_relaxation1.10811769
59MP0001348_abnormal_lacrimal_gland1.05453286
60MP0000569_abnormal_digit_pigmentation0.99847187
61MP0003075_altered_response_to0.99275998
62MP0003950_abnormal_plasma_membrane0.98584234
63MP0002396_abnormal_hematopoietic_system0.96933548
64MP0001853_heart_inflammation0.95415481
65MP0002693_abnormal_pancreas_physiology0.92955649
66MP0001919_abnormal_reproductive_system0.91614040
67MP0001663_abnormal_digestive_system0.90666561
68MP0003172_abnormal_lysosome_physiology0.88574640
69MP0001851_eye_inflammation0.86922281
70MP0002095_abnormal_skin_pigmentation0.86032844
71MP0001529_abnormal_vocalization0.85535497
72MP0008004_abnormal_stomach_pH0.84237801
73MP0000465_gastrointestinal_hemorrhage0.79237662
74MP0002998_abnormal_bone_remodeling0.78679923
75MP0002166_altered_tumor_susceptibility0.75977002
76MP0001986_abnormal_taste_sensitivity0.74946439
77MP0003795_abnormal_bone_structure0.71728201
78MP0000490_abnormal_crypts_of0.71122025
79MP0003828_pulmonary_edema0.70837293
80MP0002933_joint_inflammation0.70453213
81MP0002019_abnormal_tumor_incidence0.69142564
82MP0004145_abnormal_muscle_electrophysio0.67303965
83MP0005451_abnormal_body_composition0.66480416
84MP0009765_abnormal_xenobiotic_induced0.62673645
85MP0001727_abnormal_embryo_implantation0.62457115
86MP0000249_abnormal_blood_vessel0.61982418
87MP0001915_intracranial_hemorrhage0.60025660
88MP0003091_abnormal_cell_migration0.59978702
89MP0005167_abnormal_blood-brain_barrier0.59892580
90MP0000858_altered_metastatic_potential0.59545537
91MP0000604_amyloidosis0.58617198
92MP0000371_diluted_coat_color0.58430084
93MP0002136_abnormal_kidney_physiology0.57966675
94MP0008874_decreased_physiological_sensi0.57022377
95MP0002006_tumorigenesis0.56174333
96MP0009763_increased_sensitivity_to0.55556546
97MP0003448_altered_tumor_morphology0.55538133
98MP0004142_abnormal_muscle_tone0.53900931
99MP0003183_abnormal_peptide_metabolism0.52684425
100MP0001501_abnormal_sleep_pattern0.52587522

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)6.27794557
2Stomatitis (HP:0010280)4.50140626
3Agammaglobulinemia (HP:0004432)4.34407055
4Thrombocytosis (HP:0001894)4.25663884
5Gastrointestinal infarctions (HP:0005244)4.20131510
6Hypoplasia of the pons (HP:0012110)3.91637299
7IgA deficiency (HP:0002720)3.88698426
8Abnormality of the pons (HP:0007361)3.82935171
9Chronic sinusitis (HP:0011109)3.81682380
10Global brain atrophy (HP:0002283)3.77302791
11Abnormality of macrophages (HP:0004311)3.62538387
12Acute hepatic failure (HP:0006554)3.60626107
13Retrobulbar optic neuritis (HP:0100654)3.59309530
14Optic neuritis (HP:0100653)3.59309530
15Meningitis (HP:0001287)3.54820898
16Type I transferrin isoform profile (HP:0003642)3.48204559
17Nuclear cataract (HP:0100018)3.46100656
18Recurrent bacterial skin infections (HP:0005406)3.40965200
19Reduced antithrombin III activity (HP:0001976)3.34733662
20Gingival bleeding (HP:0000225)3.33961127
21Papilloma (HP:0012740)3.32428035
22Verrucae (HP:0200043)3.32428035
23Recurrent viral infections (HP:0004429)3.25039983
24Recurrent abscess formation (HP:0002722)3.24481480
25Orchitis (HP:0100796)3.23269951
26Glucose intolerance (HP:0000833)3.21348963
27Mediastinal lymphadenopathy (HP:0100721)3.15751309
28IgG deficiency (HP:0004315)3.15444337
29Eczematoid dermatitis (HP:0000976)3.14916896
30Myositis (HP:0100614)3.14418392
31Pulmonary infiltrates (HP:0002113)3.13148252
32Lymphopenia (HP:0001888)3.07419385
33Vasculitis (HP:0002633)3.02305863
34Recurrent pneumonia (HP:0006532)2.98136344
35Abnormality of cells of the lymphoid lineage (HP:0012140)2.94726551
36Albinism (HP:0001022)2.94161793
37Spastic paraparesis (HP:0002313)2.93168643
38Recurrent fungal infections (HP:0002841)2.91412945
39Chest pain (HP:0100749)2.90060192
40Abnormality of glycolipid metabolism (HP:0010969)2.81589123
41Abnormality of liposaccharide metabolism (HP:0010968)2.81589123
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.81589123
43Cellulitis (HP:0100658)2.81388087
44Cutaneous melanoma (HP:0012056)2.78072682
45Testicular atrophy (HP:0000029)2.76964483
46Elevated erythrocyte sedimentation rate (HP:0003565)2.76841108
47Obstructive lung disease (HP:0006536)2.74936337
48Chronic obstructive pulmonary disease (HP:0006510)2.74936337
49Abnormality of homocysteine metabolism (HP:0010919)2.72803454
50Homocystinuria (HP:0002156)2.72803454
51Megaloblastic anemia (HP:0001889)2.70249552
52Peritonitis (HP:0002586)2.69244890
53Abnormality of T cell number (HP:0011839)2.67829227
54Gastrointestinal stroma tumor (HP:0100723)2.67400106
55T lymphocytopenia (HP:0005403)2.67289935
56Spontaneous abortion (HP:0005268)2.66057556
57Epistaxis (HP:0000421)2.64821091
58Keratoconjunctivitis sicca (HP:0001097)2.64024449
59Arterial thrombosis (HP:0004420)2.61014718
60Inflammation of the large intestine (HP:0002037)2.60050474
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.55275088
62Abnormality of T cells (HP:0002843)2.50789962
63Recurrent bronchitis (HP:0002837)2.48833269
64Keratoconjunctivitis (HP:0001096)2.48792117
65Osteomyelitis (HP:0002754)2.45049824
66Restrictive lung disease (HP:0002091)2.42061311
67Hematochezia (HP:0002573)2.41370295
68Encephalitis (HP:0002383)2.41353525
69Gastrointestinal inflammation (HP:0004386)2.41267186
70Purpura (HP:0000979)2.40031626
71Prolonged partial thromboplastin time (HP:0003645)2.39710299
72Abnormality of T cell physiology (HP:0011840)2.36595897
73Chronic otitis media (HP:0000389)2.36132344
74Abnormality of the pericardium (HP:0001697)2.34494681
75Increased IgM level (HP:0003496)2.34297982
76Petechiae (HP:0000967)2.33552177
77Abnormal protein glycosylation (HP:0012346)2.32307127
78Abnormal glycosylation (HP:0012345)2.32307127
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32307127
80Abnormal protein N-linked glycosylation (HP:0012347)2.32307127
81Hypoalbuminemia (HP:0003073)2.31476499
82Abnormal albumin level (HP:0012116)2.31476499
83Recurrent gram-negative bacterial infections (HP:0005420)2.29848285
84Increased serum ferritin (HP:0003281)2.28781390
85Polyneuropathy (HP:0001271)2.27331052
86Recurrent lower respiratory tract infections (HP:0002783)2.25457339
87Fatigue (HP:0012378)2.24601068
88Keratitis (HP:0000491)2.24545306
89Sepsis (HP:0100806)2.23805883
90Abnormal glucose tolerance (HP:0001952)2.23275837
91Myocardial infarction (HP:0001658)2.21281375
92Hemoptysis (HP:0002105)2.20787760
93Severe visual impairment (HP:0001141)2.18731990
94Leukocytosis (HP:0001974)2.17604261
95Vacuolated lymphocytes (HP:0001922)2.15204019
96Prolonged bleeding time (HP:0003010)2.14018058
97Recurrent skin infections (HP:0001581)2.11930603
98Recurrent sinusitis (HP:0011108)2.10958880
99Chronic mucocutaneous candidiasis (HP:0002728)2.10722979
100Recurrent cutaneous fungal infections (HP:0011370)2.10722979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK25.97305475
2PKN25.14119621
3BRSK24.73165296
4IRAK43.78135978
5CAMKK13.30274810
6FLT33.26347611
7IRAK22.88061098
8TYK22.70084397
9MAP4K12.59837229
10IRAK12.41761249
11RIPK42.34569884
12PASK2.22213752
13TXK2.13454182
14MAP3K142.08349360
15IKBKE2.03095601
16BRSK11.97460126
17JAK31.88782626
18BTK1.85335332
19SIK31.75867903
20PIK3CG1.69733623
21AKT31.69248265
22SYK1.62572585
23TEC1.59905504
24TBK11.56100614
25BLK1.52943402
26HCK1.51173475
27ITK1.49103761
28PRPF4B1.31577471
29EIF2AK31.20899628
30TLK11.20517019
31IKBKB1.15128678
32MAP3K91.04337876
33CSK1.04190722
34ERN11.03415014
35JAK10.93196002
36STK100.92331644
37MAP3K100.92092850
38JAK20.89960382
39SIK20.86196757
40MAPK110.86011176
41TNK20.81933298
42LYN0.81887704
43MAP3K130.81080011
44TAOK20.80626930
45MATK0.79203954
46PRKCQ0.77849088
47FES0.77843385
48FGR0.76744923
49CSF1R0.74773668
50MAP3K110.74713411
51MAP2K30.74241127
52ZAP700.73185986
53STK240.73137662
54MARK30.67821467
55KIT0.66006894
56GRK60.62275639
57BMPR20.62076097
58LCK0.61403359
59TYRO30.60500603
60TAOK30.58216324
61TAOK10.56468290
62CHUK0.54699415
63STK110.52725986
64ACVR1B0.52712655
65PRKAA20.49826174
66SIK10.46737893
67PDK10.46536038
68GRK70.45953164
69IGF1R0.43866701
70MAPKAPK50.43491733
71MELK0.40559327
72NME20.40538562
73MAP3K30.38988773
74PKN10.36574458
75MET0.36538313
76TAF10.35506989
77STK40.34525890
78RET0.33247885
79ABL10.32538300
80MAP3K50.30591803
81PAK30.28461680
82NLK0.28448521
83PIM10.24917722
84BRAF0.22867034
85FGFR10.21962562
86MAP3K10.20775051
87CDC42BPA0.20585560
88SMG10.19873762
89STK38L0.17597499
90EIF2AK20.16506590
91IRAK30.16078894
92GRK50.15879705
93EGFR0.14773015
94SGK20.14630268
95MAPK30.14185117
96MST40.13171202
97CDK40.12947142
98HIPK20.11295352
99MAPK70.09617423
100MAPK120.08435168

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.58954723
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.35119706
3B cell receptor signaling pathway_Homo sapiens_hsa046623.05780395
4Allograft rejection_Homo sapiens_hsa053302.95530820
5Autoimmune thyroid disease_Homo sapiens_hsa053202.88801394
6Graft-versus-host disease_Homo sapiens_hsa053322.70853939
7Osteoclast differentiation_Homo sapiens_hsa043802.68168652
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.62699144
9Asthma_Homo sapiens_hsa053102.37085513
10Leishmaniasis_Homo sapiens_hsa051402.35961042
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24357278
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16841774
13Type I diabetes mellitus_Homo sapiens_hsa049402.08592809
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08374987
15Protein export_Homo sapiens_hsa030601.92642682
16Staphylococcus aureus infection_Homo sapiens_hsa051501.85952807
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85178320
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83514553
19T cell receptor signaling pathway_Homo sapiens_hsa046601.81041769
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79739781
21Measles_Homo sapiens_hsa051621.77113606
22Antigen processing and presentation_Homo sapiens_hsa046121.72184593
23Herpes simplex infection_Homo sapiens_hsa051681.69861784
24Regulation of autophagy_Homo sapiens_hsa041401.69840110
25Tuberculosis_Homo sapiens_hsa051521.57310852
26Influenza A_Homo sapiens_hsa051641.56927538
27Viral myocarditis_Homo sapiens_hsa054161.55895996
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.51871947
29TNF signaling pathway_Homo sapiens_hsa046681.49870287
30Toxoplasmosis_Homo sapiens_hsa051451.47998900
31Hematopoietic cell lineage_Homo sapiens_hsa046401.45989803
32Chemokine signaling pathway_Homo sapiens_hsa040621.44397739
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30747016
34Legionellosis_Homo sapiens_hsa051341.27213904
35Hepatitis B_Homo sapiens_hsa051611.24379729
36Acute myeloid leukemia_Homo sapiens_hsa052211.23736583
37Rheumatoid arthritis_Homo sapiens_hsa053231.20195797
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16232657
39Malaria_Homo sapiens_hsa051441.15201512
40Epstein-Barr virus infection_Homo sapiens_hsa051691.08294772
41Other glycan degradation_Homo sapiens_hsa005111.06644174
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01306975
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99894468
44Hepatitis C_Homo sapiens_hsa051600.91756334
45Apoptosis_Homo sapiens_hsa042100.91009994
46Non-small cell lung cancer_Homo sapiens_hsa052230.85644560
47Prolactin signaling pathway_Homo sapiens_hsa049170.83582416
48Basal transcription factors_Homo sapiens_hsa030220.82690206
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82649183
50Renal cell carcinoma_Homo sapiens_hsa052110.81426995
51FoxO signaling pathway_Homo sapiens_hsa040680.81253408
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80699457
53Olfactory transduction_Homo sapiens_hsa047400.79641406
54Chronic myeloid leukemia_Homo sapiens_hsa052200.76254261
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74823731
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.73775300
57African trypanosomiasis_Homo sapiens_hsa051430.70790092
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.69985913
59Shigellosis_Homo sapiens_hsa051310.65440905
60Viral carcinogenesis_Homo sapiens_hsa052030.64348814
61mTOR signaling pathway_Homo sapiens_hsa041500.62718719
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62441110
63Phagosome_Homo sapiens_hsa041450.61780137
64HTLV-I infection_Homo sapiens_hsa051660.59245154
65Platelet activation_Homo sapiens_hsa046110.58821718
66Pancreatic cancer_Homo sapiens_hsa052120.58460079
67Lysosome_Homo sapiens_hsa041420.58364734
68Thyroid cancer_Homo sapiens_hsa052160.56069442
69Pertussis_Homo sapiens_hsa051330.54988046
70VEGF signaling pathway_Homo sapiens_hsa043700.54891982
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54379992
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53143475
73Prostate cancer_Homo sapiens_hsa052150.51958941
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51566720
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51511780
76MAPK signaling pathway_Homo sapiens_hsa040100.49525752
77RNA degradation_Homo sapiens_hsa030180.46986738
78Colorectal cancer_Homo sapiens_hsa052100.46342339
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.43083641
80Sulfur metabolism_Homo sapiens_hsa009200.41156451
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41114247
82Endometrial cancer_Homo sapiens_hsa052130.41057292
83ErbB signaling pathway_Homo sapiens_hsa040120.38043059
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34710652
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34345401
86Dorso-ventral axis formation_Homo sapiens_hsa043200.30396461
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.28769905
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28523560
89Insulin resistance_Homo sapiens_hsa049310.27491258
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25817308
91Cholinergic synapse_Homo sapiens_hsa047250.25607562
92Rap1 signaling pathway_Homo sapiens_hsa040150.24962836
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24793041
94Type II diabetes mellitus_Homo sapiens_hsa049300.24577073
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.24407314
96Estrogen signaling pathway_Homo sapiens_hsa049150.23800592
97Inositol phosphate metabolism_Homo sapiens_hsa005620.23764884
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23543995
99Insulin signaling pathway_Homo sapiens_hsa049100.20927463
100Bladder cancer_Homo sapiens_hsa052190.20252098

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