SETSIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.91036581
2regulation of T-helper 2 cell differentiation (GO:0045628)9.82111966
3seminiferous tubule development (GO:0072520)9.76361432
4negative regulation of type 2 immune response (GO:0002829)9.73699211
5negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.87477241
6cAMP biosynthetic process (GO:0006171)8.76095059
7detection of chemical stimulus involved in sensory perception (GO:0050907)8.58697285
8negative regulation of alpha-beta T cell differentiation (GO:0046639)8.18825945
9enteric nervous system development (GO:0048484)8.08967035
10regulation of protein sumoylation (GO:0033233)7.45910491
11righting reflex (GO:0060013)7.07306441
12dendritic spine morphogenesis (GO:0060997)7.02221452
13synaptic transmission, dopaminergic (GO:0001963)6.96270632
14positive regulation of mitochondrial fission (GO:0090141)6.93705399
15heterotypic cell-cell adhesion (GO:0034113)6.43403592
16positive regulation of T-helper 1 type immune response (GO:0002827)6.29179801
17hepatocyte apoptotic process (GO:0097284)6.15799202
18detection of chemical stimulus (GO:0009593)6.15560746
19icosanoid secretion (GO:0032309)5.91110724
20arachidonic acid secretion (GO:0050482)5.91110724
21phosphatidylinositol acyl-chain remodeling (GO:0036149)5.71294428
22positive regulation of T-helper cell differentiation (GO:0045624)5.66633051
23drug transmembrane transport (GO:0006855)5.36313550
24phosphatidylserine acyl-chain remodeling (GO:0036150)5.29551432
25phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.15338214
26regulation of mitochondrial fission (GO:0090140)5.12394538
27neural tube formation (GO:0001841)4.96815716
28neuronal ion channel clustering (GO:0045161)4.91860600
29chemosensory behavior (GO:0007635)4.87918193
30icosanoid transport (GO:0071715)4.84469600
31fatty acid derivative transport (GO:1901571)4.84469600
32attachment of spindle microtubules to kinetochore (GO:0008608)4.76290470
33negative regulation of alpha-beta T cell activation (GO:0046636)4.70959125
34cilium or flagellum-dependent cell motility (GO:0001539)4.58565857
35embryonic digestive tract morphogenesis (GO:0048557)4.56848338
36hyaluronan catabolic process (GO:0030214)4.56332773
37regulation of T-helper 1 type immune response (GO:0002825)4.49855870
38vocalization behavior (GO:0071625)4.48384585
39nephron epithelium morphogenesis (GO:0072088)4.42008914
40nephron tubule morphogenesis (GO:0072078)4.42008914
41energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.39908491
42ATP hydrolysis coupled proton transport (GO:0015991)4.39908491
43positive regulation of membrane potential (GO:0045838)4.31230473
44negative regulation of actin filament bundle assembly (GO:0032232)4.31052181
45positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.30139641
46cyclic purine nucleotide metabolic process (GO:0052652)4.29431441
47retina layer formation (GO:0010842)4.27370138
48response to dietary excess (GO:0002021)4.20336311
49cellular response to glucagon stimulus (GO:0071377)4.18533175
50regulation of cAMP-mediated signaling (GO:0043949)4.17391253
51cyclic nucleotide biosynthetic process (GO:0009190)4.15960098
52protein localization to synapse (GO:0035418)4.13606175
53regulation of T-helper cell differentiation (GO:0045622)4.06117249
54water transport (GO:0006833)4.04619385
55cAMP metabolic process (GO:0046058)4.01949190
56negative regulation of cytosolic calcium ion concentration (GO:0051481)3.97264275
57dendritic spine organization (GO:0097061)3.92152812
58mitochondrial fusion (GO:0008053)3.91563048
59regulation of type 2 immune response (GO:0002828)3.89862739
60positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.76817219
61phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.76568056
62pre-miRNA processing (GO:0031054)3.66028978
63negative regulation of T cell differentiation (GO:0045581)3.65025515
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.64324930
65drug transport (GO:0015893)3.61894308
66fluid transport (GO:0042044)3.61240559
67leukotriene biosynthetic process (GO:0019370)3.59344406
68monoamine transport (GO:0015844)3.57337966
69cellular zinc ion homeostasis (GO:0006882)3.54113630
70neurofilament cytoskeleton organization (GO:0060052)3.51443464
71positive regulation of protein targeting to membrane (GO:0090314)3.48155104
72prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.47832028
73cellular response to ATP (GO:0071318)3.45550752
74positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.42199348
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41576000
76sulfur amino acid catabolic process (GO:0000098)3.38899487
77reflex (GO:0060004)3.36092689
78sequestering of metal ion (GO:0051238)3.32790979
79negative regulation of homotypic cell-cell adhesion (GO:0034111)3.26681508
80phosphatidylcholine acyl-chain remodeling (GO:0036151)3.26298741
81left/right axis specification (GO:0070986)3.23902171
82positive regulation of alpha-beta T cell differentiation (GO:0046638)3.23243431
83renal tubule morphogenesis (GO:0061333)3.21628716
84adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.18902750
85regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.18482641
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18271105
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18053127
88negative regulation of astrocyte differentiation (GO:0048712)3.17876686
89response to glucagon (GO:0033762)3.16506697
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15567305
91positive regulation of dendritic spine development (GO:0060999)3.11333922
92adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.10842612
93tooth mineralization (GO:0034505)14.1728099
94detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.8083718
95positive regulation of protein sumoylation (GO:0033235)11.7611350
96negative regulation of T-helper cell differentiation (GO:0045623)11.0987698
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.0987698
98protein K11-linked deubiquitination (GO:0035871)10.9741608
99regulation of T-helper 1 cell differentiation (GO:0045625)10.1253953
100activation of protein kinase A activity (GO:0034199)10.0339038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.21599184
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.02931382
3AR_21572438_ChIP-Seq_LNCaP_Human4.98876972
4IGF1R_20145208_ChIP-Seq_DFB_Human4.90607693
5VDR_22108803_ChIP-Seq_LS180_Human4.42624813
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.31422760
7PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.23076432
8TP53_16413492_ChIP-PET_HCT116_Human2.05120008
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01415769
10POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.01415769
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.8899396
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94086812
13YY1_22570637_ChIP-Seq_MALME-3M_Human1.89523136
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81223232
15ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76795744
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72940717
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69750768
18NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63228466
19DROSHA_22980978_ChIP-Seq_HELA_Human1.62227743
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62011958
21EZH2_22144423_ChIP-Seq_EOC_Human1.60921686
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.56865337
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55998827
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.55764882
25SMAD3_21741376_ChIP-Seq_HESCs_Human1.48093525
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46984661
27GATA1_19941826_ChIP-Seq_K562_Human1.45672969
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.45363485
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44027422
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39152876
31EGR1_19032775_ChIP-ChIP_M12_Human1.39083617
32RNF2_27304074_Chip-Seq_NSC_Mouse1.36785609
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.33239354
34RXR_22108803_ChIP-Seq_LS180_Human1.29154251
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.27687215
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26642228
37GBX2_23144817_ChIP-Seq_PC3_Human1.24861038
38ZNF274_21170338_ChIP-Seq_K562_Hela1.22952412
39ER_23166858_ChIP-Seq_MCF-7_Human1.22543098
40TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.21717094
41BCAT_22108803_ChIP-Seq_LS180_Human1.18159077
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17976109
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.17252374
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15181477
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.12275542
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11474145
47SOX2_18555785_Chip-Seq_ESCs_Mouse1.11307578
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07461707
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07079176
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06836882
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06522393
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.06423852
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06397054
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.06291948
55GATA6_21074721_ChIP-Seq_CACO-2_Human1.06039612
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.05954612
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04672345
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04515849
59STAT3_23295773_ChIP-Seq_U87_Human1.04310799
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03198922
61PHF8_20622853_ChIP-Seq_HELA_Human1.03029888
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02913728
63TBL1_22424771_ChIP-Seq_293T_Human1.02888736
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01527043
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.00980850
66SMAD4_21741376_ChIP-Seq_HESCs_Human1.00817226
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00816709
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00688557
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00256977
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98797386
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97401945
72SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95897250
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95624348
74ARNT_22903824_ChIP-Seq_MCF-7_Human0.95344240
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95269597
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92241284
77ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91309331
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90946545
79NMYC_18555785_Chip-Seq_ESCs_Mouse0.90701902
80E2F1_18555785_Chip-Seq_ESCs_Mouse0.90575117
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90529803
82PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.90454151
83SMAD4_21799915_ChIP-Seq_A2780_Human0.90430284
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.89301145
85REST_21632747_ChIP-Seq_MESCs_Mouse0.87885720
86NANOG_16518401_ChIP-PET_MESCs_Mouse0.86757213
87KLF4_18555785_Chip-Seq_ESCs_Mouse0.86613362
88HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85786439
89P53_22387025_ChIP-Seq_ESCs_Mouse0.85225098
90TCF4_22108803_ChIP-Seq_LS180_Human0.84525176
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84228859
92RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83827189
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83827189
94DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83727623
95CJUN_26792858_Chip-Seq_BT549_Human0.82590168
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82476430
97CBP_20019798_ChIP-Seq_JUKART_Human0.82476430
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.82396293
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81826867
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81022688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.44535446
2MP0004130_abnormal_muscle_cell4.66087366
3MP0004264_abnormal_extraembryonic_tissu3.98543961
4MP0003252_abnormal_bile_duct3.63080381
5MP0004133_heterotaxia2.97896839
6MP0006072_abnormal_retinal_apoptosis2.77856879
7MP0002928_abnormal_bile_duct2.74652676
8MP0002751_abnormal_autonomic_nervous2.47193422
9MP0005448_abnormal_energy_balance2.23806896
10MP0005408_hypopigmentation2.18846153
11MP0001270_distended_abdomen2.18610958
12MP0005084_abnormal_gallbladder_morpholo12.6994298
13MP0004272_abnormal_basement_membrane1.88867520
14MP0005379_endocrine/exocrine_gland_phen1.86671786
15MP0003329_amyloid_beta_deposits1.82443835
16MP0003943_abnormal_hepatobiliary_system1.71644167
17MP0005220_abnormal_exocrine_pancreas1.59675112
18MP0001529_abnormal_vocalization1.49350275
19MP0009764_decreased_sensitivity_to1.46083222
20MP0003718_maternal_effect1.44519020
21MP0005165_increased_susceptibility_to1.41558138
22MP0001905_abnormal_dopamine_level1.18208878
23MP0001958_emphysema1.16539365
24MP0002572_abnormal_emotion/affect_behav1.12389623
25MP0000604_amyloidosis1.10909756
26MP0005646_abnormal_pituitary_gland1.09551734
27MP0000470_abnormal_stomach_morphology0.99133414
28MP0002909_abnormal_adrenal_gland0.98393995
29MP0001944_abnormal_pancreas_morphology0.98043879
30MP0008569_lethality_at_weaning0.96599381
31MP0003121_genomic_imprinting0.91574803
32MP0003638_abnormal_response/metabolism_0.89259736
33MP0000465_gastrointestinal_hemorrhage0.88133865
34MP0005253_abnormal_eye_physiology0.88009893
35MP0002822_catalepsy0.82953115
36MP0000371_diluted_coat_color0.76201273
37MP0001800_abnormal_humoral_immune0.73341676
38MP0002405_respiratory_system_inflammati0.70470510
39MP0002693_abnormal_pancreas_physiology0.70350178
40MP0005164_abnormal_response_to0.69532264
41MP0001915_intracranial_hemorrhage0.69430373
42MP0004019_abnormal_vitamin_homeostasis0.67434900
43MP0002098_abnormal_vibrissa_morphology0.67191196
44MP0008469_abnormal_protein_level0.67177393
45MP0008875_abnormal_xenobiotic_pharmacok0.66534718
46MP0001790_abnormal_immune_system0.64801679
47MP0005387_immune_system_phenotype0.64801679
48MP0000703_abnormal_thymus_morphology0.63796432
49MP0002136_abnormal_kidney_physiology0.63038441
50MP0002102_abnormal_ear_morphology0.62942765
51MP0000609_abnormal_liver_physiology0.62791228
52MP0002078_abnormal_glucose_homeostasis0.62344826
53MP0003953_abnormal_hormone_level0.62191778
54MP0002735_abnormal_chemical_nociception0.62073527
55MP0005551_abnormal_eye_electrophysiolog0.59868141
56MP0003866_abnormal_defecation0.56437747
57MP0005423_abnormal_somatic_nervous0.53819063
58MP0001851_eye_inflammation0.53734427
59MP0001501_abnormal_sleep_pattern0.51949775
60MP0001986_abnormal_taste_sensitivity0.50965861
61MP0003195_calcinosis0.49401061
62MP0005645_abnormal_hypothalamus_physiol0.43767988
63MP0002736_abnormal_nociception_after0.43684226
64MP0009642_abnormal_blood_homeostasis0.43402651
65MP0001533_abnormal_skeleton_physiology0.43008759
66MP0002722_abnormal_immune_system0.42968698
67MP0001845_abnormal_inflammatory_respons0.42672871
68MP0008932_abnormal_embryonic_tissue0.40262630
69MP0002882_abnormal_neuron_morphology0.40232747
70MP0002229_neurodegeneration0.38931131
71MP0002998_abnormal_bone_remodeling0.38061893
72MP0004947_skin_inflammation0.37208215
73MP0002163_abnormal_gland_morphology0.37195008
74MP0003880_abnormal_central_pattern0.37068874
75MP0002396_abnormal_hematopoietic_system0.35814046
76MP0005395_other_phenotype0.34941732
77MP0002429_abnormal_blood_cell0.33787048
78MP0000477_abnormal_intestine_morphology0.32051449
79MP0009053_abnormal_anal_canal0.31961732
80MP0000598_abnormal_liver_morphology0.31646812
81MP0000920_abnormal_myelination0.30689869
82MP0005391_vision/eye_phenotype0.29748799
83MP0005334_abnormal_fat_pad0.29208697
84MP0002452_abnormal_antigen_presenting0.29155907
85MP0009931_abnormal_skin_appearance0.28995536
86MP0003635_abnormal_synaptic_transmissio0.28848415
87MP0002066_abnormal_motor_capabilities/c0.28344808
88MP0000716_abnormal_immune_system0.27414718
89MP0005332_abnormal_amino_acid0.27039043
90MP0000639_abnormal_adrenal_gland0.27006788
91MP0002398_abnormal_bone_marrow0.26436569
92MP0003136_yellow_coat_color0.25459705
93MP0001175_abnormal_lung_morphology0.25282817
94MP0002557_abnormal_social/conspecific_i0.25272525
95MP0004197_abnormal_fetal_growth/weight/0.25118682
96MP0002420_abnormal_adaptive_immunity0.25105073
97MP0005377_hearing/vestibular/ear_phenot0.25026535
98MP0003878_abnormal_ear_physiology0.25026535
99MP0000759_abnormal_skeletal_muscle0.24633553
100MP0002277_abnormal_respiratory_mucosa0.24390607

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.70901450
2Abnormality of renal resorption (HP:0011038)8.20954538
3Abnormality of dental color (HP:0011073)7.92255613
4Polyuria (HP:0000103)7.81142672
5Osteomalacia (HP:0002749)7.38406552
6Abnormality of the dental pulp (HP:0006479)7.24919397
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.65347362
8Abnormal urine output (HP:0012590)6.62854433
9Abnormality of renal excretion (HP:0011036)5.76056541
10Round ear (HP:0100830)5.53816958
11Volvulus (HP:0002580)4.98195373
12Chronic bronchitis (HP:0004469)4.97336241
13Toxemia of pregnancy (HP:0100603)4.64140705
14IgM deficiency (HP:0002850)4.60866585
15Molar tooth sign on MRI (HP:0002419)4.16132481
16Abnormality of midbrain morphology (HP:0002418)4.16132481
17Autoimmune thrombocytopenia (HP:0001973)4.15325904
18Lip pit (HP:0100267)3.86036086
19Nephrocalcinosis (HP:0000121)3.67141347
20Esophageal varix (HP:0002040)3.54766137
21Large earlobe (HP:0009748)3.33357840
22Rhinitis (HP:0012384)3.31894434
23Abnormal respiratory motile cilium physiology (HP:0012261)3.30527333
24Tachypnea (HP:0002789)3.25890947
25Lipoatrophy (HP:0100578)3.23708547
26Drooling (HP:0002307)3.15252274
27Depressed nasal tip (HP:0000437)3.11725882
28Panhypogammaglobulinemia (HP:0003139)3.08348783
29Excessive salivation (HP:0003781)3.01125307
30Nephronophthisis (HP:0000090)2.99344969
31Sparse lateral eyebrow (HP:0005338)2.98375853
32Hyperphosphaturia (HP:0003109)2.93662175
33Hypoparathyroidism (HP:0000829)2.86611005
34Intestinal fistula (HP:0100819)2.84516996
35Thick eyebrow (HP:0000574)2.77287579
36Glycosuria (HP:0003076)2.51526587
37Abnormality of urine glucose concentration (HP:0011016)2.51526587
38Abnormal urine phosphate concentration (HP:0012599)2.44645056
39Ectopic kidney (HP:0000086)2.41171522
40Inability to walk (HP:0002540)2.40078636
41Hepatitis (HP:0012115)2.39150653
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.36678774
43Petechiae (HP:0000967)2.36563682
44Striae distensae (HP:0001065)2.35861412
45Ureteral stenosis (HP:0000071)2.35152409
46Abnormality of the renal medulla (HP:0100957)2.34241778
47Personality changes (HP:0000751)2.32974665
48Dilated cardiomyopathy (HP:0001644)2.25813384
49Bronchitis (HP:0012387)2.25721722
50Decreased muscle mass (HP:0003199)2.24724216
51Recurrent cutaneous fungal infections (HP:0011370)2.21665461
52Chronic mucocutaneous candidiasis (HP:0002728)2.21665461
53Nephropathy (HP:0000112)2.20027104
54Agammaglobulinemia (HP:0004432)2.19309440
55Short 5th finger (HP:0009237)2.15539922
56Ureteral obstruction (HP:0006000)2.15113929
57Gingival overgrowth (HP:0000212)2.11895037
58Recurrent otitis media (HP:0000403)2.10325599
59Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.06941117
60Hypercalciuria (HP:0002150)2.02684666
61Chorioretinal coloboma (HP:0000567)2.02533217
62Sudden cardiac death (HP:0001645)2.01941775
63Abnormality of transition element cation homeostasis (HP:0011030)2.00809782
64Abnormality of the fingertips (HP:0001211)2.00476205
65Amelogenesis imperfecta (HP:0000705)11.4015199
66Overgrowth (HP:0001548)11.3712184
67Prominent supraorbital ridges (HP:0000336)1.99004148
68Abnormality of salivation (HP:0100755)1.97057220
69Periauricular skin pits (HP:0100277)1.96476241
70Preauricular pit (HP:0004467)1.96476241
71Anal stenosis (HP:0002025)1.90794663
72Preauricular skin tag (HP:0000384)1.90100993
73Delayed eruption of teeth (HP:0000684)1.88308646
74Small hand (HP:0200055)1.85291475
75Colitis (HP:0002583)1.84048902
76Renal tubular dysfunction (HP:0000124)1.83322570
77Truncal ataxia (HP:0002078)1.82492399
78Blepharitis (HP:0000498)1.81795551
79Oculomotor apraxia (HP:0000657)1.79303821
80Chondrocalcinosis (HP:0000934)1.77846243
81Stage 5 chronic kidney disease (HP:0003774)1.75348273
82Abnormality of Sharpey fibers (HP:0100685)1.74764887
83Limited elbow extension (HP:0001377)1.74693002
84Ectropion (HP:0000656)1.72175283
85Bronchiectasis (HP:0002110)1.64282585
86Prenatal maternal abnormality (HP:0002686)1.64129520
87Highly arched eyebrow (HP:0002553)1.62858984
88Skin tags (HP:0010609)1.58183498
89Palmoplantar keratoderma (HP:0000982)1.56797848
90Delayed gross motor development (HP:0002194)1.55695671
91Abnormality of small intestinal villus morphology (HP:0011472)1.55101458
92Villous atrophy (HP:0011473)1.55101458
93Torticollis (HP:0000473)1.50131650
94Aplasia/Hypoplasia of the earlobes (HP:0009906)1.48682115
95Abnormality of T cell physiology (HP:0011840)1.48675265
96Proximal placement of thumb (HP:0009623)1.42599482
97Polyneuropathy (HP:0001271)1.40373638
98Viral hepatitis (HP:0006562)1.38276933
99Abnormality of sodium homeostasis (HP:0010931)1.33484856
100Widely spaced teeth (HP:0000687)1.29876097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.57416830
2BLK4.36189957
3STK33.93977796
4RIPK43.07457001
5BMPR22.12104904
6NTRK213.8412903
7CDC42BPA1.91955795
8HIPK21.20018716
9FGFR10.93173153
10WNK30.89966864
11MAP4K20.88161910
12ZAK0.85101695
13INSRR0.77216187
14ROCK20.75703994
15SRPK10.65488874
16SYK0.63107804
17PRKCQ0.62434661
18TLK10.60027544
19PRKAA10.59189879
20SRC0.56767861
21OBSCN0.56559893
22GRK10.55896641
23FRK0.54787159
24ROCK10.54312138
25ADRBK20.53805385
26VRK10.51589447
27WNK40.49510620
28PLK40.47452136
29STK390.47081753
30MAPK150.46687876
31PLK10.46286243
32TIE10.45405416
33MUSK0.44520733
34PRKACG0.43022695
35CAMK2A0.40260085
36PRKACA0.39757275
37ABL10.38243197
38PRKACB0.36484274
39ERBB40.36367215
40OXSR10.36116907
41BUB10.34597215
42MAP3K40.33509535
43STK160.32758869
44KDR0.30714001
45TXK0.30169169
46GRK70.29295516
47MAP2K70.27152322
48WEE10.26108140
49LMTK20.25727437
50TNK20.24622435
51PRKCA0.24325229
52CSNK1A10.24284691
53PKN10.24004829
54MAPK140.23406384
55PRKCB0.23247940
56GSK3B0.23101851
57CDK30.22894034
58LYN0.22606825
59PHKG20.22361937
60PHKG10.22361937
61NTRK30.22185678
62EPHA40.22149699
63CCNB10.21704674
64CDC70.21535024
65TAOK30.21452848
66PRKCE0.20770043
67CDK10.19800435
68CASK0.19743482
69RPS6KA30.19741199
70RPS6KA50.19344804
71MARK10.17834294
72GRK50.17739452
73ITK0.17385477
74PRKCG0.17222541
75MAPK130.16168566
76PRKDC0.14288268
77GRK60.14065283
78DYRK30.13009231
79TEC0.12997013
80PIK3CG0.12968617
81MST1R0.12640890
82TNIK0.12536762
83PRKCD0.11039282
84EPHA20.10903712
85MAPK90.09972812
86RPS6KA40.09450979
87MAP2K60.09234239
88FYN0.08981645
89DAPK30.08192252
90FES0.08107168
91PIK3CA0.07700636
92ADRBK10.07330546
93IGF1R0.07300149
94CAMK2G0.06723728
95CAMK2D0.06660070
96PLK30.06588507
97AURKA0.06464481
98PINK10.06245568
99CAMK2B0.05842312
100INSR0.05642468

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.28977857
2Sulfur relay system_Homo sapiens_hsa041223.68393752
3Sulfur metabolism_Homo sapiens_hsa009203.58539157
4Ovarian steroidogenesis_Homo sapiens_hsa049133.35286979
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.30392397
6Linoleic acid metabolism_Homo sapiens_hsa005913.02825132
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.80458557
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.65526547
9Collecting duct acid secretion_Homo sapiens_hsa049662.48836295
10Bile secretion_Homo sapiens_hsa049762.34210482
11Vibrio cholerae infection_Homo sapiens_hsa051102.34126333
12Fat digestion and absorption_Homo sapiens_hsa049752.21129486
13Thyroid hormone synthesis_Homo sapiens_hsa049182.16985431
14Pancreatic secretion_Homo sapiens_hsa049722.16839982
15Salivary secretion_Homo sapiens_hsa049702.11307666
16Gastric acid secretion_Homo sapiens_hsa049712.08240103
17Cocaine addiction_Homo sapiens_hsa050302.02955894
18Synaptic vesicle cycle_Homo sapiens_hsa047211.99273724
19Circadian entrainment_Homo sapiens_hsa047131.90503971
20Glutamatergic synapse_Homo sapiens_hsa047241.85182703
21Taste transduction_Homo sapiens_hsa047421.83012218
22Insulin secretion_Homo sapiens_hsa049111.82976714
23GABAergic synapse_Homo sapiens_hsa047271.81553808
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78073350
25Morphine addiction_Homo sapiens_hsa050321.76851484
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.70995931
27Ether lipid metabolism_Homo sapiens_hsa005651.70177501
28Dilated cardiomyopathy_Homo sapiens_hsa054141.59724571
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.57378897
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52532092
31Gap junction_Homo sapiens_hsa045401.50173197
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46782393
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45352042
34Amphetamine addiction_Homo sapiens_hsa050311.41800457
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37652420
36Melanogenesis_Homo sapiens_hsa049161.34381667
37Arachidonic acid metabolism_Homo sapiens_hsa005901.32105157
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25924086
39GnRH signaling pathway_Homo sapiens_hsa049121.24652834
40Oxytocin signaling pathway_Homo sapiens_hsa049211.15365120
41Cholinergic synapse_Homo sapiens_hsa047251.14711376
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08863392
43Calcium signaling pathway_Homo sapiens_hsa040201.05859885
44Platelet activation_Homo sapiens_hsa046111.03068112
45Estrogen signaling pathway_Homo sapiens_hsa049151.01546883
46Circadian rhythm_Homo sapiens_hsa047100.98607999
47Oocyte meiosis_Homo sapiens_hsa041140.91057429
48Pyruvate metabolism_Homo sapiens_hsa006200.91030552
49Dorso-ventral axis formation_Homo sapiens_hsa043200.84820265
50Serotonergic synapse_Homo sapiens_hsa047260.83117593
51Alcoholism_Homo sapiens_hsa050340.75452502
52RNA degradation_Homo sapiens_hsa030180.75054481
53Chemokine signaling pathway_Homo sapiens_hsa040620.65197546
54ECM-receptor interaction_Homo sapiens_hsa045120.63020365
55Parkinsons disease_Homo sapiens_hsa050120.61650129
56Rheumatoid arthritis_Homo sapiens_hsa053230.61255187
57Primary immunodeficiency_Homo sapiens_hsa053400.60236516
58Systemic lupus erythematosus_Homo sapiens_hsa053220.59488420
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59206567
60Oxidative phosphorylation_Homo sapiens_hsa001900.46752962
61cAMP signaling pathway_Homo sapiens_hsa040240.43113391
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.42523115
63Purine metabolism_Homo sapiens_hsa002300.39125839
64Dopaminergic synapse_Homo sapiens_hsa047280.37652733
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34050086
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33933557
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33777604
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.28268095
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.27398220
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.26928136
71Hedgehog signaling pathway_Homo sapiens_hsa043400.23551438
72Retinol metabolism_Homo sapiens_hsa008300.23275887
73Nicotine addiction_Homo sapiens_hsa050330.21014719
74Prion diseases_Homo sapiens_hsa050200.17981368
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17443720
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.16406492
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15438549
78Type I diabetes mellitus_Homo sapiens_hsa049400.14808811
79Rap1 signaling pathway_Homo sapiens_hsa040150.14110315
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12939327
81Glucagon signaling pathway_Homo sapiens_hsa049220.12711067
82Phototransduction_Homo sapiens_hsa047440.12345187
83Staphylococcus aureus infection_Homo sapiens_hsa051500.11988605
84HTLV-I infection_Homo sapiens_hsa051660.11005046
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09035202
86Renin secretion_Homo sapiens_hsa049240.08773153
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08300171
88Ras signaling pathway_Homo sapiens_hsa040140.06921558
89Chemical carcinogenesis_Homo sapiens_hsa052040.05562901
90Viral carcinogenesis_Homo sapiens_hsa052030.05494495
91Phagosome_Homo sapiens_hsa041450.03866179
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.02476736
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.02475593
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.02187906
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.01957720
96Caffeine metabolism_Homo sapiens_hsa002320.00932613
97Asthma_Homo sapiens_hsa05310-0.0380812
98Antigen processing and presentation_Homo sapiens_hsa04612-0.0247323
99Tuberculosis_Homo sapiens_hsa05152-0.0076909
100Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0064392

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