SEZ6L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.17429319
2synaptic vesicle maturation (GO:0016188)6.15130271
3locomotory exploration behavior (GO:0035641)5.97544220
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.73955916
5presynaptic membrane organization (GO:0097090)5.25509103
6synaptic vesicle exocytosis (GO:0016079)5.20621034
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17185292
8vocalization behavior (GO:0071625)5.14426743
9regulation of synaptic vesicle exocytosis (GO:2000300)5.04835716
10glutamate secretion (GO:0014047)5.02532471
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.95639184
12regulation of glutamate receptor signaling pathway (GO:1900449)4.69280529
13exploration behavior (GO:0035640)4.60250935
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.57324308
15neuron cell-cell adhesion (GO:0007158)4.55873191
16regulation of synaptic vesicle transport (GO:1902803)4.53251492
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.42155017
18neurotransmitter secretion (GO:0007269)4.32926178
19regulation of neuronal synaptic plasticity (GO:0048168)4.31821695
20protein localization to synapse (GO:0035418)4.29346626
21neuronal action potential propagation (GO:0019227)4.19943230
22layer formation in cerebral cortex (GO:0021819)4.17582877
23dendritic spine morphogenesis (GO:0060997)4.16053138
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13085799
25mechanosensory behavior (GO:0007638)4.06646495
26pyrimidine nucleobase catabolic process (GO:0006208)3.96050693
27synaptic transmission, glutamatergic (GO:0035249)3.95899521
28proline transport (GO:0015824)3.93918059
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91432282
30regulation of synapse structural plasticity (GO:0051823)3.83915899
31central nervous system myelination (GO:0022010)3.83118589
32axon ensheathment in central nervous system (GO:0032291)3.83118589
33glutamate receptor signaling pathway (GO:0007215)3.79078294
34gamma-aminobutyric acid transport (GO:0015812)3.75633374
35L-amino acid import (GO:0043092)3.72000778
36activation of protein kinase A activity (GO:0034199)3.69729612
37cellular potassium ion homeostasis (GO:0030007)3.69692100
38long-term memory (GO:0007616)3.66416874
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65260472
40cerebellar Purkinje cell differentiation (GO:0021702)3.63477531
41positive regulation of membrane potential (GO:0045838)3.62622250
42neuromuscular process controlling posture (GO:0050884)3.60286054
43neurotransmitter-gated ion channel clustering (GO:0072578)3.59216092
44sodium ion export (GO:0071436)3.57885341
45potassium ion homeostasis (GO:0055075)3.57662811
46cell communication by electrical coupling (GO:0010644)3.56881093
47neuron recognition (GO:0008038)3.55635572
48C4-dicarboxylate transport (GO:0015740)3.53715019
49neuron-neuron synaptic transmission (GO:0007270)3.51851031
50nucleobase catabolic process (GO:0046113)3.51311327
51neurotransmitter transport (GO:0006836)3.50798412
52chemosensory behavior (GO:0007635)3.46942352
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44340437
54auditory behavior (GO:0031223)3.44107133
55dendrite morphogenesis (GO:0048813)3.43635456
56axonal fasciculation (GO:0007413)3.42139897
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40010277
58postsynaptic membrane organization (GO:0001941)3.36628723
59positive regulation of synapse maturation (GO:0090129)3.36361184
60regulation of synaptic plasticity (GO:0048167)3.32094859
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30392646
62response to pheromone (GO:0019236)3.30154240
63synaptic vesicle endocytosis (GO:0048488)3.29306788
64innervation (GO:0060384)3.29178151
65neuromuscular process controlling balance (GO:0050885)3.27546053
66regulation of postsynaptic membrane potential (GO:0060078)3.27235279
67prepulse inhibition (GO:0060134)3.27016533
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24188291
69transmission of nerve impulse (GO:0019226)3.23536426
70cellular sodium ion homeostasis (GO:0006883)3.22368423
71regulation of vesicle fusion (GO:0031338)3.21547481
72regulation of neurotransmitter levels (GO:0001505)3.21084859
73response to auditory stimulus (GO:0010996)3.20984846
74regulation of ARF protein signal transduction (GO:0032012)3.20773687
75regulation of neurotransmitter secretion (GO:0046928)3.20029709
76amino acid import (GO:0043090)3.19834607
77neuromuscular synaptic transmission (GO:0007274)3.19040934
78startle response (GO:0001964)3.16837812
79regulation of calcium ion-dependent exocytosis (GO:0017158)3.14605085
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12019545
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11504860
82neurotransmitter uptake (GO:0001504)3.10076273
83detection of calcium ion (GO:0005513)3.09416447
84dendritic spine organization (GO:0097061)3.08660632
85gamma-aminobutyric acid signaling pathway (GO:0007214)3.08280609
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07599084
87long-term synaptic potentiation (GO:0060291)3.06736244
88negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04870202
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03621751
90vesicle transport along microtubule (GO:0047496)3.03297969
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01760258
92cochlea development (GO:0090102)3.00279011
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00185583
94* cerebellar Purkinje cell layer development (GO:0021680)2.99486078
95neuronal ion channel clustering (GO:0045161)2.99380371
96membrane depolarization during action potential (GO:0086010)2.97877136
97intraspecies interaction between organisms (GO:0051703)2.96800882
98social behavior (GO:0035176)2.96800882
99positive regulation of dendritic spine morphogenesis (GO:0061003)2.96283018
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95943637
101regulation of dendritic spine morphogenesis (GO:0061001)2.94750638
102adult walking behavior (GO:0007628)2.94065987
103positive regulation of synapse assembly (GO:0051965)2.93816394
104positive regulation of potassium ion transmembrane transport (GO:1901381)2.91310288
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.90826124
106regulation of respiratory system process (GO:0044065)2.90418335
107establishment of mitochondrion localization (GO:0051654)2.90096021
108membrane depolarization (GO:0051899)2.89463404
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88410114
110cerebellum development (GO:0021549)2.88083446
111regulation of neurotransmitter transport (GO:0051588)2.87646554
112synapse assembly (GO:0007416)2.87532240
113presynaptic membrane assembly (GO:0097105)2.86379761
114neuromuscular process (GO:0050905)2.83895420
115learning (GO:0007612)2.83859230
116negative regulation of dendrite development (GO:2000171)2.82090479
117central nervous system projection neuron axonogenesis (GO:0021952)2.82026478
118regulation of dendritic spine development (GO:0060998)2.81631044
119positive regulation of dendritic spine development (GO:0060999)2.81324427
120regulation of synaptic transmission (GO:0050804)2.81082523
121signal release (GO:0023061)2.80618088
122glycine transport (GO:0015816)2.80494544
123positive regulation of exocytosis (GO:0045921)2.78676590
124potassium ion import (GO:0010107)2.78646992
125acidic amino acid transport (GO:0015800)2.78473705
126* synapse organization (GO:0050808)2.78247384
127regulation of exocytosis (GO:0017157)2.77724615
128membrane hyperpolarization (GO:0060081)2.77336028
129cerebellar granule cell differentiation (GO:0021707)2.76345609
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75909664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47220212
2GBX2_23144817_ChIP-Seq_PC3_Human3.14062816
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00776859
4REST_21632747_ChIP-Seq_MESCs_Mouse2.95605770
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93815742
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90725342
7DROSHA_22980978_ChIP-Seq_HELA_Human2.59736112
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58112049
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58112049
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56150625
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53908007
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.52962816
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47770145
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45143158
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.44931900
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.44591073
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41780650
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36453676
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35162206
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33816216
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.30155025
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29206932
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.17443040
24* EED_16625203_ChIP-ChIP_MESCs_Mouse2.15612088
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06867689
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06228630
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91784370
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90212787
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90202512
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87580171
31ZNF274_21170338_ChIP-Seq_K562_Hela1.77008315
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66248873
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61142010
34AR_21572438_ChIP-Seq_LNCaP_Human1.54668568
35SMAD4_21799915_ChIP-Seq_A2780_Human1.53817732
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.47484739
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45860807
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44235376
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43806143
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42089556
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.36320760
42IGF1R_20145208_ChIP-Seq_DFB_Human1.35313927
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33876729
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32749036
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.32649255
46* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28057321
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27045531
48AR_19668381_ChIP-Seq_PC3_Human1.26713046
49KDM2B_26808549_Chip-Seq_K562_Human1.24609506
50STAT3_23295773_ChIP-Seq_U87_Human1.22900804
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21240389
52* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20069253
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19712915
54FUS_26573619_Chip-Seq_HEK293_Human1.19100347
55* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18680602
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18490375
57LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16947286
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.15804177
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15142430
60* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14600388
61* AR_25329375_ChIP-Seq_VCAP_Human1.14399748
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14179460
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12434505
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11165567
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11035371
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10278769
67P300_19829295_ChIP-Seq_ESCs_Human1.10113333
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.10061630
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09664883
70* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09223124
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09129496
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09099787
73TAF15_26573619_Chip-Seq_HEK293_Human1.08844753
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.08299045
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07899496
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07515971
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.07131139
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06286611
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06044211
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.05725050
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05140357
82BCAT_22108803_ChIP-Seq_LS180_Human1.04996749
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01971440
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.01421006
85VDR_22108803_ChIP-Seq_LS180_Human1.01353822
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01199548
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00513032
88SMAD3_21741376_ChIP-Seq_ESCs_Human1.00508575
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00324809
90* TCF4_23295773_ChIP-Seq_U87_Human1.00322639
91* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99461481
92ER_23166858_ChIP-Seq_MCF-7_Human0.98593793
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98446776
94SOX9_26525672_Chip-Seq_HEART_Mouse0.98362375
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.98337490
96TET1_21490601_ChIP-Seq_MESCs_Mouse0.96494968
97RNF2_27304074_Chip-Seq_NSC_Mouse0.96396165
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95957669
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.95903895
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95860953
101* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95090321
102AHR_22903824_ChIP-Seq_MCF-7_Human0.94151011
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92970602
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92077335
105KDM2B_26808549_Chip-Seq_REH_Human0.91175926
106P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90977273
107ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90208276
108FLI1_21867929_ChIP-Seq_TH2_Mouse0.89790838
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89747493
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89478547
111CTCF_27219007_Chip-Seq_Bcells_Human0.87923397
112* RUNX2_22187159_ChIP-Seq_PCA_Human0.86985295
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86313943
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84935939
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.83750928
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82697101
117RXR_22108803_ChIP-Seq_LS180_Human0.82538761
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81846951
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80657271
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79640339
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79640339
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.77708017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38943414
2MP0003880_abnormal_central_pattern4.15859159
3MP0003635_abnormal_synaptic_transmissio3.98852732
4MP0004270_analgesia3.72169159
5MP0002063_abnormal_learning/memory/cond3.17057950
6MP0009745_abnormal_behavioral_response3.06403642
7MP0002064_seizures2.91647551
8MP0005423_abnormal_somatic_nervous2.78851524
9MP0009780_abnormal_chondrocyte_physiolo2.71060627
10MP0009046_muscle_twitch2.70467071
11MP0002572_abnormal_emotion/affect_behav2.66626659
12MP0002909_abnormal_adrenal_gland2.60045149
13MP0002734_abnormal_mechanical_nocicepti2.53664293
14MP0001968_abnormal_touch/_nociception2.51950299
15MP0002272_abnormal_nervous_system2.37332611
16MP0001486_abnormal_startle_reflex2.28529553
17MP0001501_abnormal_sleep_pattern2.15504340
18MP0003283_abnormal_digestive_organ2.13466126
19MP0005645_abnormal_hypothalamus_physiol2.10998456
20MP0003122_maternal_imprinting2.07615632
21MP0002733_abnormal_thermal_nociception2.03710691
22MP0001440_abnormal_grooming_behavior1.97818468
23MP0004858_abnormal_nervous_system1.93502652
24MP0006276_abnormal_autonomic_nervous1.92540074
25MP0005646_abnormal_pituitary_gland1.91495054
26MP0002735_abnormal_chemical_nociception1.89741887
27MP0001970_abnormal_pain_threshold1.84538569
28MP0008569_lethality_at_weaning1.82446155
29MP0000778_abnormal_nervous_system1.81847067
30MP0002067_abnormal_sensory_capabilities1.81287576
31MP0003329_amyloid_beta_deposits1.79793354
32MP0002184_abnormal_innervation1.78911591
33MP0002557_abnormal_social/conspecific_i1.75844792
34MP0004811_abnormal_neuron_physiology1.75669395
35MP0002736_abnormal_nociception_after1.68158611
36MP0010386_abnormal_urinary_bladder1.65685258
37MP0003879_abnormal_hair_cell1.65171543
38MP0003787_abnormal_imprinting1.60713572
39MP0000955_abnormal_spinal_cord1.60051160
40MP0005386_behavior/neurological_phenoty1.55121689
41MP0004924_abnormal_behavior1.55121689
42MP0004885_abnormal_endolymph1.48016794
43MP0008961_abnormal_basal_metabolism1.46869463
44MP0000013_abnormal_adipose_tissue1.41528507
45MP0002882_abnormal_neuron_morphology1.38620397
46MP0000569_abnormal_digit_pigmentation1.38503975
47MP0001502_abnormal_circadian_rhythm1.38201604
48MP0002822_catalepsy1.37148889
49MP0003136_yellow_coat_color1.36372431
50* MP0002066_abnormal_motor_capabilities/c1.35886213
51MP0001984_abnormal_olfaction1.34761703
52MP0004043_abnormal_pH_regulation1.25138452
53MP0003633_abnormal_nervous_system1.23889924
54MP0002653_abnormal_ependyma_morphology1.21538189
55MP0003172_abnormal_lysosome_physiology1.18465770
56MP0002638_abnormal_pupillary_reflex1.10958750
57MP0002152_abnormal_brain_morphology1.09878455
58MP0004145_abnormal_muscle_electrophysio1.09814626
59MP0003183_abnormal_peptide_metabolism1.04708726
60MP0002837_dystrophic_cardiac_calcinosis1.04695175
61MP0001905_abnormal_dopamine_level1.04513481
62MP0005253_abnormal_eye_physiology1.04260689
63MP0001529_abnormal_vocalization1.04237476
64MP0004142_abnormal_muscle_tone1.04105314
65MP0002069_abnormal_eating/drinking_beha1.03825997
66MP0002693_abnormal_pancreas_physiology1.03794464
67MP0008877_abnormal_DNA_methylation1.02840735
68MP0003631_nervous_system_phenotype1.02473235
69MP0001188_hyperpigmentation1.00015338
70MP0005535_abnormal_body_temperature0.98022057
71MP0000631_abnormal_neuroendocrine_gland0.96499950
72MP0000566_synostosis0.93172502
73MP0001944_abnormal_pancreas_morphology0.92752232
74MP0002229_neurodegeneration0.91827389
75MP0003868_abnormal_feces_composition0.91727550
76MP0003634_abnormal_glial_cell0.90256873
77MP0000026_abnormal_inner_ear0.86012900
78MP0005379_endocrine/exocrine_gland_phen0.80783399
79MP0004085_abnormal_heartbeat0.80037451
80MP0001299_abnormal_eye_distance/0.79739156
81MP0003632_abnormal_nervous_system0.79314388
82MP0001986_abnormal_taste_sensitivity0.78381620
83MP0002234_abnormal_pharynx_morphology0.78127482
84MP0006072_abnormal_retinal_apoptosis0.77122440
85MP0004742_abnormal_vestibular_system0.75057416
86MP0002877_abnormal_melanocyte_morpholog0.74387893
87MP0003861_abnormal_nervous_system0.73648803
88MP0002078_abnormal_glucose_homeostasis0.73589686
89MP0003011_delayed_dark_adaptation0.72868006
90MP0003690_abnormal_glial_cell0.71490976
91MP0000604_amyloidosis0.71426871
92MP0001177_atelectasis0.70854312
93MP0000751_myopathy0.70723595
94MP0001963_abnormal_hearing_physiology0.70540682
95MP0003075_altered_response_to0.69816896
96MP0002928_abnormal_bile_duct0.68832697
97MP0005187_abnormal_penis_morphology0.68510725
98MP0003121_genomic_imprinting0.68193872
99MP0003123_paternal_imprinting0.66700955
100MP0002751_abnormal_autonomic_nervous0.66632127
101MP0003953_abnormal_hormone_level0.66580585
102MP0004133_heterotaxia0.65951090
103MP0000678_abnormal_parathyroid_gland0.65545170
104MP0008872_abnormal_physiological_respon0.65075918
105MP0002876_abnormal_thyroid_physiology0.64359630
106MP0005167_abnormal_blood-brain_barrier0.64211626
107MP0005551_abnormal_eye_electrophysiolog0.63639684
108MP0000920_abnormal_myelination0.63575775
109MP0003137_abnormal_impulse_conducting0.63166561
110MP0005394_taste/olfaction_phenotype0.63145653
111MP0005499_abnormal_olfactory_system0.63145653
112MP0010770_preweaning_lethality0.62993377
113MP0002082_postnatal_lethality0.62993377
114MP0001664_abnormal_digestion0.62413944
115MP0010769_abnormal_survival0.61375829
116MP0008874_decreased_physiological_sensi0.60840353
117MP0001485_abnormal_pinna_reflex0.60802963
118MP0002752_abnormal_somatic_nervous0.60338068

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.77152547
2Visual hallucinations (HP:0002367)5.84456494
3Myokymia (HP:0002411)5.60622061
4Focal seizures (HP:0007359)5.29278509
5Epileptic encephalopathy (HP:0200134)4.16833257
6Progressive cerebellar ataxia (HP:0002073)4.10143033
7Absence seizures (HP:0002121)3.96897766
8Atonic seizures (HP:0010819)3.89263804
9Action tremor (HP:0002345)3.86308648
10Papilledema (HP:0001085)3.79284643
11Supranuclear gaze palsy (HP:0000605)3.72891444
12Generalized tonic-clonic seizures (HP:0002069)3.64484267
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.62862827
14Dialeptic seizures (HP:0011146)3.57300740
15Febrile seizures (HP:0002373)3.56629029
16Ankle clonus (HP:0011448)3.38508365
17Depression (HP:0000716)3.27359884
18Agitation (HP:0000713)3.06408995
19Impaired vibration sensation in the lower limbs (HP:0002166)3.03374755
20Poor eye contact (HP:0000817)3.00420575
21Epileptiform EEG discharges (HP:0011182)2.93099079
22Broad-based gait (HP:0002136)2.91914860
23Truncal ataxia (HP:0002078)2.89271156
24Mutism (HP:0002300)2.89132142
25EEG with generalized epileptiform discharges (HP:0011198)2.87564533
26Abnormal eating behavior (HP:0100738)2.85791372
27Anxiety (HP:0000739)2.84588787
28Postural instability (HP:0002172)2.83601310
29Hypsarrhythmia (HP:0002521)2.80759610
30Impaired smooth pursuit (HP:0007772)2.79073583
31Impaired social interactions (HP:0000735)2.75450289
32Abnormal social behavior (HP:0012433)2.75450289
33Genetic anticipation (HP:0003743)2.75016804
34Gaze-evoked nystagmus (HP:0000640)2.73186521
35Dysmetria (HP:0001310)2.72909596
36Excessive salivation (HP:0003781)2.70659724
37Drooling (HP:0002307)2.70659724
38Urinary bladder sphincter dysfunction (HP:0002839)2.69736652
39Hemiparesis (HP:0001269)2.69579170
40Dysdiadochokinesis (HP:0002075)2.65325161
41Neurofibrillary tangles (HP:0002185)2.63367391
42Abnormality of the lower motor neuron (HP:0002366)2.60624867
43Pheochromocytoma (HP:0002666)2.58834677
44Amblyopia (HP:0000646)2.57636290
45Failure to thrive in infancy (HP:0001531)2.56583550
46Cerebral inclusion bodies (HP:0100314)2.56397515
47Gait imbalance (HP:0002141)2.52703395
48Ventricular fibrillation (HP:0001663)2.52418580
49Spastic gait (HP:0002064)2.51933177
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.49227250
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.49227250
52Hemiplegia (HP:0002301)2.47235754
53Intestinal atresia (HP:0011100)2.44395286
54Abnormality of ocular smooth pursuit (HP:0000617)2.44258180
55Sleep apnea (HP:0010535)2.42753093
56Intention tremor (HP:0002080)2.41017648
57Abnormality of binocular vision (HP:0011514)2.39284978
58Diplopia (HP:0000651)2.39284978
59Hyperventilation (HP:0002883)2.34482750
60Bradykinesia (HP:0002067)2.34340786
61Insomnia (HP:0100785)2.33337849
62Polyphagia (HP:0002591)2.31134518
63Megalencephaly (HP:0001355)2.25870998
64Urinary urgency (HP:0000012)2.23359469
65Limb dystonia (HP:0002451)2.23262709
66Split foot (HP:0001839)2.23145363
67Oligodactyly (hands) (HP:0001180)2.21356369
68Abnormality of calcium-phosphate metabolism (HP:0100530)2.19464024
69Torticollis (HP:0000473)2.19175414
70Hyperinsulinemic hypoglycemia (HP:0000825)2.15285857
71Progressive inability to walk (HP:0002505)2.14140262
72Neuroendocrine neoplasm (HP:0100634)2.13447134
73Abnormality of the corticospinal tract (HP:0002492)2.08306306
74Peripheral hypomyelination (HP:0007182)2.07943131
75Amyotrophic lateral sclerosis (HP:0007354)2.07834537
76Stereotypic behavior (HP:0000733)2.06023744
77Focal dystonia (HP:0004373)2.05607615
78Neoplasm of the heart (HP:0100544)2.05172450
79Lower limb muscle weakness (HP:0007340)2.02397446
80Absent speech (HP:0001344)2.02303826
81Scanning speech (HP:0002168)2.02243790
82Specific learning disability (HP:0001328)2.00627852
83Decreased circulating renin level (HP:0003351)2.00159301
84Retinal dysplasia (HP:0007973)1.99230797
85Postural tremor (HP:0002174)1.98062866
86Medial flaring of the eyebrow (HP:0010747)1.97033935
87Clonus (HP:0002169)1.96907679
88Fetal akinesia sequence (HP:0001989)1.96126470
89Hypercortisolism (HP:0001578)1.95096945
90Gait ataxia (HP:0002066)1.94340369
91Spastic tetraplegia (HP:0002510)1.94173537
92Morphological abnormality of the pyramidal tract (HP:0002062)1.93888641
93Generalized myoclonic seizures (HP:0002123)1.93398292
94Psychosis (HP:0000709)1.92590929
95Bundle branch block (HP:0011710)1.92470756
96Macroorchidism (HP:0000053)1.91758764
97Neuronal loss in central nervous system (HP:0002529)1.90405221
98Menstrual irregularities (HP:0000858)1.88119952
99Impaired vibratory sensation (HP:0002495)1.88059542
100Hypoglycemic seizures (HP:0002173)1.86593126
101Increased circulating renin level (HP:0000848)1.86506706
102Status epilepticus (HP:0002133)1.84486731
103Abnormality of the labia minora (HP:0012880)1.83116838
104Congenital primary aphakia (HP:0007707)1.82999961
105Pachygyria (HP:0001302)1.82981301
106Hypoplasia of the corpus callosum (HP:0002079)1.82438503
107Obstructive sleep apnea (HP:0002870)1.81759696
108Hepatoblastoma (HP:0002884)1.81677752
109Blue irides (HP:0000635)1.80514226
110Termporal pattern (HP:0011008)1.78569624
111Insidious onset (HP:0003587)1.78569624
112Poor suck (HP:0002033)1.77388238
113Abnormality of salivation (HP:0100755)1.77026396
114Pointed chin (HP:0000307)1.76360115
115Craniofacial dystonia (HP:0012179)1.75971731
116Rapidly progressive (HP:0003678)1.75878975
117Akinesia (HP:0002304)1.75851617
118Protruding tongue (HP:0010808)1.75233720
119Muscular hypotonia of the trunk (HP:0008936)1.74349376
120Rigidity (HP:0002063)1.74326340
121Aqueductal stenosis (HP:0002410)1.73608925
122Nephrogenic diabetes insipidus (HP:0009806)1.73172048
123Inability to walk (HP:0002540)1.71464887
124Large for gestational age (HP:0001520)1.69094998
125True hermaphroditism (HP:0010459)1.68934332
126Genital tract atresia (HP:0001827)1.68459176
127Gastrointestinal atresia (HP:0002589)1.68133040
128Type II lissencephaly (HP:0007260)1.67815258
129Neoplasm of the oral cavity (HP:0100649)1.63869032
130Optic nerve hypoplasia (HP:0000609)1.62891444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.87200681
2MAP3K94.03538113
3MARK13.58487599
4EPHA42.91917319
5MAP3K42.79924515
6PRKD32.75644027
7MINK12.56856807
8PAK62.43968205
9NTRK22.32215822
10MAP2K72.16542853
11FRK2.14662964
12DAPK22.13285657
13NTRK12.02731490
14CAMKK11.84076330
15KSR21.79838194
16UHMK11.78978371
17MAP3K121.75115415
18MAP2K41.74292400
19CDK51.60732587
20KSR11.59367017
21MAP3K21.55122390
22TNIK1.46323242
23INSRR1.43543123
24MAPK131.43513863
25DYRK21.41862654
26TYRO31.32536126
27CAMKK21.30216142
28PNCK1.27772536
29DAPK11.25795633
30CDK191.24863265
31STK381.23525465
32GRK51.23014313
33CASK1.22667011
34PRKCG1.21111183
35SIK21.19804856
36PRPF4B1.15039408
37PRKCH1.13531816
38MAPK151.12514695
39CSNK1G31.11902286
40PKN11.10297083
41PAK31.10061566
42RIPK41.04322603
43PLK21.03035407
44FES1.02030769
45ALK1.01064507
46RET1.00328649
47CSNK1G10.99565962
48PHKG20.99016346
49PHKG10.99016346
50CSNK1A1L0.98057182
51SCYL20.97863897
52TAOK10.96706827
53MAP4K20.96097001
54MAP3K10.94015501
55CDK180.92337959
56CAMK2A0.91257222
57CAMK10.90240643
58CDK150.89972410
59SGK4940.88756879
60SGK2230.88756879
61CDC42BPA0.88370516
62STK110.87632995
63CDK140.85952061
64BMPR1B0.82775526
65CAMK2B0.79221676
66LATS20.78007672
67CAMK1G0.77979654
68CDK11A0.77711071
69PDGFRA0.77405071
70WNK30.77061177
71ARAF0.76909972
72MARK20.75194461
73HIPK20.75179329
74CSNK1G20.74494504
75DYRK1A0.70758994
76FER0.66789150
77SGK20.66222501
78SGK10.65358237
79MAP3K130.65231223
80SGK30.64569870
81RIPK10.64014916
82CAMK1D0.63458834
83PDK10.56335794
84RPS6KA30.53025241
85ADRBK20.53014274
86ERBB20.52685682
87PRKCE0.52566692
88PDPK10.51772640
89OXSR10.51093820
90PRKCZ0.49466897
91PRKG10.49401304
92STK390.49202099
93CSNK1A10.48518896
94CAMK2D0.46834087
95CSNK1D0.46637976
96ROCK20.46538483
97NEK60.46443369
98FYN0.46414536
99EPHA30.46021468
100MAPK100.46015075
101TAOK30.45940022
102PRKACA0.45926729
103RPS6KA20.45916511
104BRSK10.45039511
105LMTK20.44723940
106GRK10.44510100
107PASK0.44190481
108ROCK10.43983344
109SIK30.43820213
110TNK20.43478369
111FGFR20.43116609
112BCR0.41532926
113PINK10.40652785
114ICK0.40084630
115CDK30.39827561
116PTK20.38891460
117PTK2B0.38879251
118WNK10.38081868
119TRIM280.36906421
120CAMK40.36200549
121EPHB20.36180831
122ERBB30.35847841
123WNK40.35348648
124CAMK2G0.34816940
125BMPR20.34645746
126TSSK60.34365192
127PRKD20.33351311
128LIMK10.32848207
129CCNB10.32523218
130PRKCA0.32487941
131CSNK1E0.31562276
132PRKAA10.31019301

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43587255
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18271628
3Insulin secretion_Homo sapiens_hsa049112.65031228
4GABAergic synapse_Homo sapiens_hsa047272.60528039
5Long-term potentiation_Homo sapiens_hsa047202.58022964
6Circadian entrainment_Homo sapiens_hsa047132.57711172
7Amphetamine addiction_Homo sapiens_hsa050312.45842294
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44984262
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44083076
10Glutamatergic synapse_Homo sapiens_hsa047242.43322854
11Morphine addiction_Homo sapiens_hsa050322.24344229
12Olfactory transduction_Homo sapiens_hsa047402.24067157
13Dopaminergic synapse_Homo sapiens_hsa047282.11327609
14Salivary secretion_Homo sapiens_hsa049701.95894337
15Cholinergic synapse_Homo sapiens_hsa047251.90281059
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89610931
17Cocaine addiction_Homo sapiens_hsa050301.85395690
18Taste transduction_Homo sapiens_hsa047421.83599245
19Type II diabetes mellitus_Homo sapiens_hsa049301.82203938
20Gastric acid secretion_Homo sapiens_hsa049711.77862417
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71042253
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61293678
23Serotonergic synapse_Homo sapiens_hsa047261.60301882
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58249228
25Long-term depression_Homo sapiens_hsa047301.56218079
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.56093529
27Renin secretion_Homo sapiens_hsa049241.44468941
28Oxytocin signaling pathway_Homo sapiens_hsa049211.43987631
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40061898
30GnRH signaling pathway_Homo sapiens_hsa049121.36995938
31Calcium signaling pathway_Homo sapiens_hsa040201.35864948
32Gap junction_Homo sapiens_hsa045401.28103763
33Collecting duct acid secretion_Homo sapiens_hsa049661.25339321
34Estrogen signaling pathway_Homo sapiens_hsa049151.25272187
35Vibrio cholerae infection_Homo sapiens_hsa051101.20547030
36cAMP signaling pathway_Homo sapiens_hsa040241.19802490
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18217332
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13184806
39Butanoate metabolism_Homo sapiens_hsa006501.11497856
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09815262
41Glioma_Homo sapiens_hsa052141.09688053
42Pancreatic secretion_Homo sapiens_hsa049721.08770558
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07573888
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07017539
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06570460
46Axon guidance_Homo sapiens_hsa043601.06003218
47Type I diabetes mellitus_Homo sapiens_hsa049401.05772962
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03984961
49Melanogenesis_Homo sapiens_hsa049161.02771753
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01662436
51Nitrogen metabolism_Homo sapiens_hsa009101.00239904
52ErbB signaling pathway_Homo sapiens_hsa040120.99270943
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99184468
54Vitamin B6 metabolism_Homo sapiens_hsa007500.98836647
55Thyroid hormone synthesis_Homo sapiens_hsa049180.95837412
56Dorso-ventral axis formation_Homo sapiens_hsa043200.89352199
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88371459
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.87000692
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.79441423
60Oocyte meiosis_Homo sapiens_hsa041140.78494519
61Glucagon signaling pathway_Homo sapiens_hsa049220.74020928
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.71918086
63Choline metabolism in cancer_Homo sapiens_hsa052310.71623461
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71437162
65Cardiac muscle contraction_Homo sapiens_hsa042600.69373913
66mTOR signaling pathway_Homo sapiens_hsa041500.68339242
67MAPK signaling pathway_Homo sapiens_hsa040100.67948480
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65677111
69Dilated cardiomyopathy_Homo sapiens_hsa054140.64307219
70Circadian rhythm_Homo sapiens_hsa047100.62129040
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61862552
72Alzheimers disease_Homo sapiens_hsa050100.61821196
73Oxidative phosphorylation_Homo sapiens_hsa001900.59747375
74Prion diseases_Homo sapiens_hsa050200.58740502
75VEGF signaling pathway_Homo sapiens_hsa043700.58609011
76Inositol phosphate metabolism_Homo sapiens_hsa005620.54415189
77Alcoholism_Homo sapiens_hsa050340.54237794
78Ras signaling pathway_Homo sapiens_hsa040140.53844261
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52934846
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52780460
81Endocytosis_Homo sapiens_hsa041440.52577151
82Insulin signaling pathway_Homo sapiens_hsa049100.52172861
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51938827
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50776600
85Endometrial cancer_Homo sapiens_hsa052130.50556030
86Bile secretion_Homo sapiens_hsa049760.47249998
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.47094507
88Renal cell carcinoma_Homo sapiens_hsa052110.45325204
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45103463
90Ether lipid metabolism_Homo sapiens_hsa005650.44941539
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44754003
92Parkinsons disease_Homo sapiens_hsa050120.44555073
93Wnt signaling pathway_Homo sapiens_hsa043100.43956591
94Rap1 signaling pathway_Homo sapiens_hsa040150.41433161
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41300204
96beta-Alanine metabolism_Homo sapiens_hsa004100.41286773
97Regulation of autophagy_Homo sapiens_hsa041400.41229325
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40823762
99Hippo signaling pathway_Homo sapiens_hsa043900.40076991
100Prolactin signaling pathway_Homo sapiens_hsa049170.39904976
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39511766
102Phototransduction_Homo sapiens_hsa047440.39018201
103Fatty acid metabolism_Homo sapiens_hsa012120.39012918
104Fatty acid biosynthesis_Homo sapiens_hsa000610.36801936
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36634620
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36189733
107Ovarian steroidogenesis_Homo sapiens_hsa049130.35456942
108Non-small cell lung cancer_Homo sapiens_hsa052230.35088775
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34935711
110Hedgehog signaling pathway_Homo sapiens_hsa043400.34392805
111Mineral absorption_Homo sapiens_hsa049780.33807140
112Propanoate metabolism_Homo sapiens_hsa006400.32611765
113ABC transporters_Homo sapiens_hsa020100.31923803
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30434865
115Protein export_Homo sapiens_hsa030600.29510725
116Lysosome_Homo sapiens_hsa041420.28696766
117Fatty acid elongation_Homo sapiens_hsa000620.27231948
118Chemokine signaling pathway_Homo sapiens_hsa040620.26567851
119N-Glycan biosynthesis_Homo sapiens_hsa005100.25438913
120Insulin resistance_Homo sapiens_hsa049310.23706248
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23265121

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