SF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.43472057
2DNA unwinding involved in DNA replication (GO:0006268)4.56134255
3negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.55631516
4regulation of histone H3-K27 methylation (GO:0061085)4.43373294
5pre-miRNA processing (GO:0031054)4.34274231
6histone H3-K36 demethylation (GO:0070544)4.15724996
7negative regulation of RNA splicing (GO:0033119)4.06987252
8thymic T cell selection (GO:0045061)4.01349993
9dosage compensation (GO:0007549)3.96140598
10heterochromatin organization (GO:0070828)3.91560223
11negative regulation of mRNA processing (GO:0050686)3.91537119
12glucocorticoid receptor signaling pathway (GO:0042921)3.75271166
13mRNA stabilization (GO:0048255)3.74088591
14RNA stabilization (GO:0043489)3.74088591
15nuclear pore complex assembly (GO:0051292)3.73137682
16nuclear pore organization (GO:0006999)3.72664585
17negative regulation of mRNA metabolic process (GO:1903312)3.69474207
18protein localization to kinetochore (GO:0034501)3.68816737
19regulation of translational fidelity (GO:0006450)3.65209861
20negative regulation of histone methylation (GO:0031061)3.63279672
21response to muramyl dipeptide (GO:0032495)3.61461056
22intracellular estrogen receptor signaling pathway (GO:0030520)3.58573983
23negative thymic T cell selection (GO:0045060)3.56836714
24mannose metabolic process (GO:0006013)3.51472055
253-UTR-mediated mRNA stabilization (GO:0070935)3.45951361
26positive regulation of histone deacetylation (GO:0031065)3.45414367
27T cell selection (GO:0045058)3.40615049
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38760780
29negative regulation of cell killing (GO:0031342)3.38760780
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36611881
31mitotic nuclear envelope disassembly (GO:0007077)3.36246402
32negative T cell selection (GO:0043383)3.35716940
33protein-DNA complex disassembly (GO:0032986)3.34878931
34nucleosome disassembly (GO:0006337)3.34878931
35mitotic sister chromatid cohesion (GO:0007064)3.34398120
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.34135604
37regulation of RNA export from nucleus (GO:0046831)3.33321885
38tolerance induction (GO:0002507)3.30616851
39positive T cell selection (GO:0043368)3.30478220
40alternative mRNA splicing, via spliceosome (GO:0000380)3.26059674
41histone H4-K12 acetylation (GO:0043983)3.25658871
42DNA duplex unwinding (GO:0032508)3.24437391
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20488840
44DNA geometric change (GO:0032392)3.20254313
45antigen processing and presentation of endogenous antigen (GO:0019883)3.18689529
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17313484
47nuclear envelope disassembly (GO:0051081)3.17185320
48membrane disassembly (GO:0030397)3.17185320
49protein localization to chromosome, centromeric region (GO:0071459)3.15131949
50regulation of sister chromatid cohesion (GO:0007063)3.14252442
51folic acid-containing compound biosynthetic process (GO:0009396)3.13980485
52histone lysine demethylation (GO:0070076)3.12355980
53positive regulation of gene expression, epigenetic (GO:0045815)3.11694977
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10704732
55embryonic process involved in female pregnancy (GO:0060136)3.09418097
56sister chromatid segregation (GO:0000819)3.09405896
57response to laminar fluid shear stress (GO:0034616)3.06472681
58histone H3-K9 demethylation (GO:0033169)3.04716610
59corticosteroid receptor signaling pathway (GO:0031958)3.04104304
60leukocyte aggregation (GO:0070486)3.00743221
61positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.00478908
62regulation of mRNA stability (GO:0043488)3.00070196
63histone demethylation (GO:0016577)2.99222707
64modulation by virus of host process (GO:0019054)2.96344095
65negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.96155164
66positive thymic T cell selection (GO:0045059)2.94275842
67mitotic sister chromatid segregation (GO:0000070)2.90418649
68regulation of gamma-delta T cell differentiation (GO:0045586)2.90094419
69spliceosomal tri-snRNP complex assembly (GO:0000244)2.88509520
70chromatin assembly (GO:0031497)2.88042701
71peptidyl-lysine dimethylation (GO:0018027)2.87786144
72B cell receptor signaling pathway (GO:0050853)2.85515847
73negative regulation of gene expression, epigenetic (GO:0045814)2.83134300
74positive regulation of RNA splicing (GO:0033120)2.82966351
75regulation of RNA stability (GO:0043487)2.82251613
76trophectodermal cell differentiation (GO:0001829)2.80885765
77regulation of histone H3-K9 methylation (GO:0051570)2.80685190
78regulation of stem cell maintenance (GO:2000036)2.80566253
79apoptotic process involved in morphogenesis (GO:0060561)2.78217055
80NIK/NF-kappaB signaling (GO:0038061)2.77173673
81modulation by symbiont of host cellular process (GO:0044068)2.76620455
82Peyers patch development (GO:0048541)2.76034192
83mucosal-associated lymphoid tissue development (GO:0048537)2.76034192
84histone H2A monoubiquitination (GO:0035518)2.75155474
85peptidyl-arginine omega-N-methylation (GO:0035247)2.73641343
86regulation of chromatin binding (GO:0035561)2.73567137
87regulation of ARF protein signal transduction (GO:0032012)2.73494632
88NLS-bearing protein import into nucleus (GO:0006607)2.73248730
89histone H4 deacetylation (GO:0070933)2.73023169
90positive regulation of chromosome segregation (GO:0051984)2.72351799
91regulation of translational termination (GO:0006449)2.71834720
92chromatin silencing (GO:0006342)2.70753261
93regulation of gene silencing by RNA (GO:0060966)2.70496233
94regulation of posttranscriptional gene silencing (GO:0060147)2.70496233
95regulation of gene silencing by miRNA (GO:0060964)2.70496233
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70277128
97paraxial mesoderm development (GO:0048339)2.69979458
98gene silencing (GO:0016458)2.69646544
99nuclear envelope organization (GO:0006998)2.69276896
100focal adhesion assembly (GO:0048041)2.69213114
101cell-substrate adherens junction assembly (GO:0007045)2.69213114
102histone H4-K16 acetylation (GO:0043984)2.68978942
103regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68303970
104adherens junction assembly (GO:0034333)2.67704243
105pore complex assembly (GO:0046931)2.67572929
106regulation of B cell receptor signaling pathway (GO:0050855)2.67170431
107histone H3 deacetylation (GO:0070932)2.65250010
108gene silencing by RNA (GO:0031047)2.65072741
109maternal placenta development (GO:0001893)2.63668794
110* mRNA splicing, via spliceosome (GO:0000398)2.63416214
111* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.63416214
112nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.63359370
113translesion synthesis (GO:0019985)2.62925577
114positive regulation of protein deacetylation (GO:0090312)2.62473465
115modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61753223
116positive regulation by organism of defense response of other organism involved in symbiotic interact2.61753223
117modulation by symbiont of host immune response (GO:0052553)2.61753223
118positive regulation by symbiont of host defense response (GO:0052509)2.61753223
119modulation by symbiont of host defense response (GO:0052031)2.61753223
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61753223
121histone H3-K4 methylation (GO:0051568)2.61307039
122germinal center formation (GO:0002467)2.61204965
123regulation of histone H3-K4 methylation (GO:0051569)2.60992112
124histone H4-K8 acetylation (GO:0043982)2.60583747
125histone H4-K5 acetylation (GO:0043981)2.60583747
126regulation of ARF GTPase activity (GO:0032312)2.59616566
127regulation of nucleobase-containing compound transport (GO:0032239)2.59088784
128* RNA splicing, via transesterification reactions (GO:0000375)2.58933036
129positive regulation of SMAD protein import into nucleus (GO:0060391)2.57976757
130IMP biosynthetic process (GO:0006188)2.56958640
131signal complex assembly (GO:0007172)2.56833109
132establishment of apical/basal cell polarity (GO:0035089)2.56415614
133protein demethylation (GO:0006482)2.55735321
134protein dealkylation (GO:0008214)2.55735321
135DNA strand elongation involved in DNA replication (GO:0006271)2.55586722
136cytoplasmic mRNA processing body assembly (GO:0033962)2.55263602
137poly(A)+ mRNA export from nucleus (GO:0016973)2.55074861
138positive regulation of Rap GTPase activity (GO:0032854)2.53232684
139cellular response to interleukin-4 (GO:0071353)2.52443823
140cellular response to epidermal growth factor stimulus (GO:0071364)2.52369137
141activation of Rac GTPase activity (GO:0032863)2.51146155
142negative regulation of myotube differentiation (GO:0010832)2.50728184
143positive regulation by host of viral transcription (GO:0043923)2.49628681
144regulation of gamma-delta T cell activation (GO:0046643)2.49116984
145histone H3-K4 trimethylation (GO:0080182)2.49017499
146regulation of defense response to virus by virus (GO:0050690)2.48840427
147peptidyl-arginine N-methylation (GO:0035246)2.48638466
148peptidyl-arginine methylation (GO:0018216)2.48638466
149protein localization to chromosome (GO:0034502)2.48388636
150mitotic chromosome condensation (GO:0007076)2.48176283
151activation of MAPKKK activity (GO:0000185)2.46751116
152termination of RNA polymerase II transcription (GO:0006369)2.46750048
153detection of bacterium (GO:0016045)2.46656568
154DNA replication initiation (GO:0006270)2.46369887
155DNA conformation change (GO:0071103)2.45968445
156regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45708228
157positive regulation of granulocyte differentiation (GO:0030854)2.45324082
158regulation of DNA damage checkpoint (GO:2000001)2.44356764
159mRNA transport (GO:0051028)2.43299286
160natural killer cell differentiation (GO:0001779)2.43202549
161regulation of telomere maintenance via telomerase (GO:0032210)2.43005944
162negative regulation of histone modification (GO:0031057)2.42624508
163histone H4 acetylation (GO:0043967)2.42401565
164regulation of NFAT protein import into nucleus (GO:0051532)2.42246516
165positive regulation of gamma-delta T cell activation (GO:0046645)2.42149552
166positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.40985122
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.39933570
168cellular response to virus (GO:0098586)2.39713720
169response to peptidoglycan (GO:0032494)2.39622617
170activation of JUN kinase activity (GO:0007257)2.39471757
171stress fiber assembly (GO:0043149)2.39339673
172regulation of mammary gland epithelial cell proliferation (GO:0033599)2.39165566
173megakaryocyte development (GO:0035855)2.37104262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36138457
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.69421077
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.17671540
4MYC_22102868_ChIP-Seq_BL_Human4.16355013
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13278300
6VDR_21846776_ChIP-Seq_THP-1_Human2.82692309
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55231373
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51963176
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.35648976
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31296593
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27274667
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.24251972
13KDM2B_26808549_Chip-Seq_DND41_Human2.18736038
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.07017290
15CIITA_25753668_ChIP-Seq_RAJI_Human2.06408978
16* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04974040
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02468504
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91702852
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.83268435
20MAF_26560356_Chip-Seq_TH1_Human1.81277962
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.78882207
22UTX_26944678_Chip-Seq_JUKART_Human1.77506006
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76655790
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70581275
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67060902
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.63255150
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62345071
28* XRN2_22483619_ChIP-Seq_HELA_Human1.61006775
29* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59471975
30SCL_19346495_ChIP-Seq_HPC-7_Human1.55299760
31* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55259849
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54909930
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52684340
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51481367
35* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49152952
36VDR_24763502_ChIP-Seq_THP-1_Human1.46962612
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46891834
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44790866
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.44337302
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43420936
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.42907916
42* P68_20966046_ChIP-Seq_HELA_Human1.40788256
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40576501
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40203170
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38621897
46* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38112856
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37922513
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37241997
49AR_21909140_ChIP-Seq_LNCAP_Human1.35689165
50LXR_22292898_ChIP-Seq_THP-1_Human1.35147612
51NCOR1_26117541_ChIP-Seq_K562_Human1.35059489
52* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32798995
53* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32671372
54KDM5A_27292631_Chip-Seq_BREAST_Human1.32332868
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32023844
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31680803
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31113378
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.31105680
59* MYB_26560356_Chip-Seq_TH1_Human1.30508704
60* SMC4_20622854_ChIP-Seq_HELA_Human1.27478403
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26516982
62* MYB_26560356_Chip-Seq_TH2_Human1.25775734
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25745351
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23946764
65* MAF_26560356_Chip-Seq_TH2_Human1.23240079
66RACK7_27058665_Chip-Seq_MCF-7_Human1.22537280
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22506669
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21778821
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21778821
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21778821
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21746905
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21038818
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20425149
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19716635
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19445429
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18612170
77RUNX_20019798_ChIP-Seq_JUKART_Human1.18440285
78* TET1_21451524_ChIP-Seq_MESCs_Mouse1.18404330
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18343116
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17851565
81SPI1_23127762_ChIP-Seq_K562_Human1.17842489
82* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17824602
83* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17276554
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.17039482
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.16858838
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16587135
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15591532
88ATF3_27146783_Chip-Seq_COLON_Human1.15167716
89* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14945223
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14675902
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13742408
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.13456560
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.13255880
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.12848794
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12834777
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12676517
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11572977
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11465442
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.10778195
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10685410
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10217340
102ZNF263_19887448_ChIP-Seq_K562_Human1.09930414
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09861985
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09636577
105* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09373768
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08867286
107CHD1_26751641_Chip-Seq_LNCaP_Human1.08594171
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07778075
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04684483
110* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04114324
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04068408
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03385421
113* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03251523
114* CLOCK_20551151_ChIP-Seq_293T_Human1.02815435
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02599141
116* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02424957
117STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02346007
118TFEB_21752829_ChIP-Seq_HELA_Human1.01140705
119KDM2B_26808549_Chip-Seq_K562_Human1.00317176
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00197962
121* BCOR_27268052_Chip-Seq_Bcells_Human0.99055310
122* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98546432
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98025559
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97745926
125* SPI1_23547873_ChIP-Seq_NB4_Human0.97585681
126MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96683684
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96200440
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95964008
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95305929
130* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95203931
131TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94347605
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94100475
133CREB1_26743006_Chip-Seq_LNCaP_Human0.93637224
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93436291
135GATA1_19941826_ChIP-Seq_K562_Human0.92666626
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92513112
137TP53_22127205_ChIP-Seq_IMR90_Human0.92267310
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91738689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.08441292
2MP0005076_abnormal_cell_differentiation3.04602944
3MP0003436_decreased_susceptibility_to2.93877074
4MP0008057_abnormal_DNA_replication2.84900474
5MP0003111_abnormal_nucleus_morphology2.76530348
6MP0009278_abnormal_bone_marrow2.65847211
7MP0003705_abnormal_hypodermis_morpholog2.53935113
8MP0010094_abnormal_chromosome_stability2.48198238
9MP0003077_abnormal_cell_cycle2.45823997
10MP0004957_abnormal_blastocyst_morpholog2.42015535
11MP0002396_abnormal_hematopoietic_system2.35708394
12MP0005451_abnormal_body_composition2.35364832
13MP0002009_preneoplasia2.31346279
14MP0010030_abnormal_orbit_morphology2.31229520
15MP0003693_abnormal_embryo_hatching2.25570954
16MP0004808_abnormal_hematopoietic_stem2.05888527
17MP0001730_embryonic_growth_arrest2.05831778
18MP0000350_abnormal_cell_proliferation2.04274337
19MP0001348_abnormal_lacrimal_gland2.01197647
20MP0008961_abnormal_basal_metabolism1.97254920
21MP0003300_gastrointestinal_ulcer1.96802928
22MP0003303_peritoneal_inflammation1.83587719
23MP0003172_abnormal_lysosome_physiology1.82511633
24MP0004197_abnormal_fetal_growth/weight/1.82190456
25MP0001835_abnormal_antigen_presentation1.81780880
26MP0008260_abnormal_autophagy1.79074289
27MP0002653_abnormal_ependyma_morphology1.77757770
28MP0002084_abnormal_developmental_patter1.75380376
29MP0005380_embryogenesis_phenotype1.71029601
30MP0001672_abnormal_embryogenesis/_devel1.71029601
31MP0003984_embryonic_growth_retardation1.67936984
32MP0002088_abnormal_embryonic_growth/wei1.66932057
33MP0005000_abnormal_immune_tolerance1.66694760
34MP0008007_abnormal_cellular_replicative1.66511145
35MP0002085_abnormal_embryonic_tissue1.65035016
36MP0005397_hematopoietic_system_phenotyp1.64631733
37MP0001545_abnormal_hematopoietic_system1.64631733
38MP0002086_abnormal_extraembryonic_tissu1.63817117
39MP0001697_abnormal_embryo_size1.62311287
40MP0003566_abnormal_cell_adhesion1.61799504
41MP0001849_ear_inflammation1.61499733
42MP0000703_abnormal_thymus_morphology1.61338825
43MP0005409_darkened_coat_color1.59868014
44MP0010307_abnormal_tumor_latency1.58469233
45MP0005666_abnormal_adipose_tissue1.57081551
46MP0000733_abnormal_muscle_development1.56561112
47MP0001790_abnormal_immune_system1.56365262
48MP0005387_immune_system_phenotype1.56365262
49MP0003763_abnormal_thymus_physiology1.55031009
50MP0000678_abnormal_parathyroid_gland1.49924055
51MP0004381_abnormal_hair_follicle1.49910926
52MP0009053_abnormal_anal_canal1.48580048
53MP0002723_abnormal_immune_serum1.48278389
54MP0002080_prenatal_lethality1.46671169
55MP0005025_abnormal_response_to1.44317430
56MP0000537_abnormal_urethra_morphology1.44287788
57MP0002398_abnormal_bone_marrow1.40996142
58MP0005058_abnormal_lysosome_morphology1.40014062
59MP0003123_paternal_imprinting1.39540417
60MP0000490_abnormal_crypts_of1.38852072
61MP0002419_abnormal_innate_immunity1.36790195
62MP0000685_abnormal_immune_system1.36115046
63MP0002249_abnormal_larynx_morphology1.32663643
64MP0001851_eye_inflammation1.27537678
65MP0003567_abnormal_fetal_cardiomyocyte1.25740180
66MP0001853_heart_inflammation1.24900043
67MP0008058_abnormal_DNA_repair1.24367381
68MP0008932_abnormal_embryonic_tissue1.22980751
69MP0003115_abnormal_respiratory_system1.22527550
70MP0005375_adipose_tissue_phenotype1.21152943
71MP0003119_abnormal_digestive_system1.20951797
72MP0005023_abnormal_wound_healing1.20300319
73MP0002722_abnormal_immune_system1.19786877
74MP0004858_abnormal_nervous_system1.19198275
75MP0002019_abnormal_tumor_incidence1.18627998
76MP0005671_abnormal_response_to1.16277253
77MP0002925_abnormal_cardiovascular_devel1.15523369
78MP0009672_abnormal_birth_weight1.15294106
79MP0000428_abnormal_craniofacial_morphol1.14786499
80MP0004510_myositis1.14440751
81MP0003283_abnormal_digestive_organ1.12866201
82MP0000313_abnormal_cell_death1.11002975
83MP0002998_abnormal_bone_remodeling1.10714786
84MP0005464_abnormal_platelet_physiology1.10215143
85MP0001293_anophthalmia1.09343872
86MP0006054_spinal_hemorrhage1.08717641
87MP0000689_abnormal_spleen_morphology1.07808498
88MP0001915_intracranial_hemorrhage1.07321774
89MP0009333_abnormal_splenocyte_physiolog1.06857376
90MP0003890_abnormal_embryonic-extraembry1.06673131
91MP0003121_genomic_imprinting1.06510387
92MP0002796_impaired_skin_barrier1.04672835
93MP0001800_abnormal_humoral_immune1.04269894
94MP0005310_abnormal_salivary_gland1.03084688
95MP0002092_abnormal_eye_morphology1.01990753
96MP0009703_decreased_birth_body1.01534273
97MP0004185_abnormal_adipocyte_glucose0.99803253
98MP0002877_abnormal_melanocyte_morpholog0.97651158
99MP0004264_abnormal_extraembryonic_tissu0.97140440
100MP0001533_abnormal_skeleton_physiology0.96915942
101MP0002429_abnormal_blood_cell0.95860599
102MP0003828_pulmonary_edema0.95335208
103MP0002089_abnormal_postnatal_growth/wei0.95279154
104MP0000716_abnormal_immune_system0.94575213
105MP0008770_decreased_survivor_rate0.92554969
106MP0003935_abnormal_craniofacial_develop0.91540655
107MP0003453_abnormal_keratinocyte_physiol0.90974569
108MP0002132_abnormal_respiratory_system0.90615834
109MP0002405_respiratory_system_inflammati0.89608645
110MP0003091_abnormal_cell_migration0.89500955
111MP0002006_tumorigenesis0.89341070
112MP0003191_abnormal_cellular_cholesterol0.88202348
113MP0002697_abnormal_eye_size0.88129728
114MP0000858_altered_metastatic_potential0.87345124
115MP0010630_abnormal_cardiac_muscle0.86798729
116MP0002166_altered_tumor_susceptibility0.84017097
117MP0004233_abnormal_muscle_weight0.83710985
118MP0000266_abnormal_heart_morphology0.83113513
119MP0002932_abnormal_joint_morphology0.82670777
120MP0010234_abnormal_vibrissa_follicle0.82132396
121MP0000003_abnormal_adipose_tissue0.82025788
122MP0003866_abnormal_defecation0.81996043
123MP0001873_stomach_inflammation0.81739404
124MP0009931_abnormal_skin_appearance0.81261432
125MP0004947_skin_inflammation0.81071964
126MP0005621_abnormal_cell_physiology0.77947072
127MP0002933_joint_inflammation0.77767288
128MP0000477_abnormal_intestine_morphology0.77050805
129MP0002111_abnormal_tail_morphology0.76844832
130MP0001784_abnormal_fluid_regulation0.76249547
131MP0002420_abnormal_adaptive_immunity0.76068193
132MP0000465_gastrointestinal_hemorrhage0.75595024
133MP0002452_abnormal_antigen_presenting0.75285813
134MP0010155_abnormal_intestine_physiology0.74334990
135MP0002970_abnormal_white_adipose0.74143663
136MP0001819_abnormal_immune_cell0.73990901
137MP0000432_abnormal_head_morphology0.72517736
138MP0004133_heterotaxia0.72291743
139MP0009115_abnormal_fat_cell0.71243530

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.77599696
2Hyperacusis (HP:0010780)3.54590183
3Broad face (HP:0000283)3.29998710
4Eczematoid dermatitis (HP:0000976)3.20202698
5Abnormality of the fingertips (HP:0001211)3.07560757
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02425696
7Short 4th metacarpal (HP:0010044)3.02425696
8Ependymoma (HP:0002888)2.95687673
9Increased nuchal translucency (HP:0010880)2.95542603
10Increased density of long bones (HP:0006392)2.87777787
11Long eyelashes (HP:0000527)2.73905153
12Selective tooth agenesis (HP:0001592)2.66207943
13Abnormal number of incisors (HP:0011064)2.64740206
14Proximal placement of thumb (HP:0009623)2.64172323
15Renal duplication (HP:0000075)2.62608561
16Cerebral aneurysm (HP:0004944)2.61076618
17Increased IgE level (HP:0003212)2.58037582
18Deviation of the thumb (HP:0009603)2.57348703
19Pseudobulbar signs (HP:0002200)2.56281321
20Basal cell carcinoma (HP:0002671)2.53822552
21Trigonocephaly (HP:0000243)2.51139946
22Colitis (HP:0002583)2.50282633
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41512433
24Gastrointestinal stroma tumor (HP:0100723)2.39932196
25Shallow orbits (HP:0000586)2.38277958
26Skin tags (HP:0010609)2.37108109
27Volvulus (HP:0002580)2.36134661
28Heterotopia (HP:0002282)2.31263771
29Slow saccadic eye movements (HP:0000514)2.28318185
30Abnormality of the 4th metacarpal (HP:0010012)2.27990471
31Broad palm (HP:0001169)2.27561023
32Macroorchidism (HP:0000053)2.26717151
33Agammaglobulinemia (HP:0004432)2.25464421
34Dislocated radial head (HP:0003083)2.22521241
35Prominent nose (HP:0000448)2.20713023
36Panhypogammaglobulinemia (HP:0003139)2.15617213
37Abnormality of the astrocytes (HP:0100707)2.15428231
38Astrocytoma (HP:0009592)2.15428231
39Renovascular hypertension (HP:0100817)2.13768057
40Segmental peripheral demyelination/remyelination (HP:0003481)2.13657925
41Flat acetabular roof (HP:0003180)2.12950043
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.12655392
43Abnormality of the distal phalanx of the thumb (HP:0009617)2.12548348
44Metaphyseal cupping (HP:0003021)2.12238893
45Ulnar bowing (HP:0003031)2.10813410
46Elfin facies (HP:0004428)2.10326780
47Meningitis (HP:0001287)2.10068976
48Genu recurvatum (HP:0002816)2.09388873
49Abnormality of the columella (HP:0009929)2.08783444
50Preauricular skin tag (HP:0000384)2.07292504
51Dysmetric saccades (HP:0000641)2.06720128
52Abnormality of the radial head (HP:0003995)2.04699722
53Inflammation of the large intestine (HP:0002037)2.00961881
54Cutis marmorata (HP:0000965)1.99165955
55Medulloblastoma (HP:0002885)1.99019861
56Pointed chin (HP:0000307)1.97807793
57Distal lower limb amyotrophy (HP:0008944)1.97704592
58Polygenic inheritance (HP:0010982)1.97174861
59High pitched voice (HP:0001620)1.97061783
60Spinal cord lesions (HP:0100561)1.96847503
61Syringomyelia (HP:0003396)1.96847503
62Emphysema (HP:0002097)1.96617136
63Fatigue (HP:0012378)1.96282672
64Abnormality of the thoracic spine (HP:0100711)1.95887085
65Overriding aorta (HP:0002623)1.95540653
66Insomnia (HP:0100785)1.95517934
67Seborrheic dermatitis (HP:0001051)1.95390695
68Skull defect (HP:0001362)1.95151583
69Broad thumb (HP:0011304)1.95095164
70Disproportionate tall stature (HP:0001519)1.94709438
71Neoplasm of the oral cavity (HP:0100649)1.94633193
72Recurrent fungal infections (HP:0002841)1.93988209
73Viral hepatitis (HP:0006562)1.93395525
74Cellulitis (HP:0100658)1.92764261
75Protrusio acetabuli (HP:0003179)1.92630330
76Supernumerary ribs (HP:0005815)1.89667177
77Malignant gastrointestinal tract tumors (HP:0006749)1.89150711
78Gastrointestinal carcinoma (HP:0002672)1.89150711
79Abnormal delayed hypersensitivity skin test (HP:0002963)1.87392819
80Recurrent abscess formation (HP:0002722)1.86319166
81Recurrent bacterial skin infections (HP:0005406)1.85621130
82Hallux valgus (HP:0001822)1.84583072
83Bicuspid aortic valve (HP:0001647)1.84186209
84Limited elbow extension (HP:0001377)1.84100709
85Thin bony cortex (HP:0002753)1.83710171
86Neoplasm of striated muscle (HP:0009728)1.83481117
87Chronic obstructive pulmonary disease (HP:0006510)1.82806795
88Obstructive lung disease (HP:0006536)1.82806795
89Deviation of the hallux (HP:0010051)1.82708065
90Overlapping toe (HP:0001845)1.82660895
91Rib fusion (HP:0000902)1.80325825
92Obsessive-compulsive behavior (HP:0000722)1.79940539
93Bowel diverticulosis (HP:0005222)1.79524835
94Anal stenosis (HP:0002025)1.78715161
95Mediastinal lymphadenopathy (HP:0100721)1.78264426
96Germ cell neoplasia (HP:0100728)1.77227528
97Neonatal hypoglycemia (HP:0001998)1.76728707
98Gingivitis (HP:0000230)1.76673141
99Thoracic kyphosis (HP:0002942)1.76157698
100Prolonged bleeding time (HP:0003010)1.74213818
101Easy fatigability (HP:0003388)1.74041191
102Bowel incontinence (HP:0002607)1.73428129
103Mitral valve prolapse (HP:0001634)1.72682159
104Persistence of primary teeth (HP:0006335)1.72673547
105Gastrointestinal infarctions (HP:0005244)1.72441682
106Facial hemangioma (HP:0000329)1.71570923
107Megalocornea (HP:0000485)1.71275802
108Rectal prolapse (HP:0002035)1.71066722
109Urethral obstruction (HP:0000796)1.70916876
110Spontaneous hematomas (HP:0007420)1.70528169
111Recurrent viral infections (HP:0004429)1.70154948
112Lymphopenia (HP:0001888)1.69877941
113Abnormality of cells of the lymphoid lineage (HP:0012140)1.69514194
114Ectopic kidney (HP:0000086)1.69510087
115Large earlobe (HP:0009748)1.69194322
116Hemorrhage of the eye (HP:0011885)1.68839713
117Increased variability in muscle fiber diameter (HP:0003557)1.68326953
118Supernumerary bones of the axial skeleton (HP:0009144)1.68136707
119Increased connective tissue (HP:0009025)1.67900801
120Hypercortisolism (HP:0001578)1.67855260
121Vertebral arch anomaly (HP:0008438)1.66894865
122Aortic aneurysm (HP:0004942)1.66529832
123Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66468297
124Verrucae (HP:0200043)1.66435279
125Papilloma (HP:0012740)1.66435279
126Pustule (HP:0200039)1.66378499
127Thin ribs (HP:0000883)1.66082968
128Mitral regurgitation (HP:0001653)1.66038021
129Flat cornea (HP:0007720)1.65719866
130Long palpebral fissure (HP:0000637)1.65444829
131Atresia of the external auditory canal (HP:0000413)1.64181596
132Patellar aplasia (HP:0006443)1.63752671
133Abnormality of macrophages (HP:0004311)1.63114055
134Hypertensive crisis (HP:0100735)1.62301639
135Short phalanx of the thumb (HP:0009660)1.62266544
136Neoplasm of the heart (HP:0100544)1.62096023
137Narrow palate (HP:0000189)1.61846659
138Peripheral hypomyelination (HP:0007182)1.61534972
139Abnormality of oral frenula (HP:0000190)1.61513645
140Annular pancreas (HP:0001734)1.61422499
141Abnormality of the intervertebral disk (HP:0005108)1.61067996
142Achilles tendon contracture (HP:0001771)1.60774088
143Gastrointestinal inflammation (HP:0004386)1.60683337
144Deep palmar crease (HP:0006191)1.60417129
145Spina bifida occulta (HP:0003298)1.60244014
146Asymmetry of the thorax (HP:0001555)1.60198191
147Short 5th finger (HP:0009237)1.59993121
148Papilledema (HP:0001085)1.59796754
149Subacute progressive viral hepatitis (HP:0006572)1.59436311
150Abnormality of skeletal muscle fiber size (HP:0012084)1.58140374
151Aneurysm (HP:0002617)1.57268180
152Abnormal large intestine physiology (HP:0012700)1.56882233
153Restrictive lung disease (HP:0002091)1.56680198
154Glioma (HP:0009733)1.56556336
155Aplasia/Hypoplasia of the thymus (HP:0010515)1.56015537
156Neuronal loss in central nervous system (HP:0002529)1.55723678
157Patellar dislocation (HP:0002999)1.55712758
158Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.55692279
159Ankle contracture (HP:0006466)1.55610742
160Broad phalanges of the hand (HP:0009768)1.54620329
161Osteomyelitis (HP:0002754)1.54542155
162Sparse lateral eyebrow (HP:0005338)1.54026977
163Ankyloglossia (HP:0010296)1.53668128
164Arnold-Chiari malformation (HP:0002308)1.52827932
165Abnormality of the peritoneum (HP:0002585)1.51923631
166Cafe-au-lait spot (HP:0000957)1.51484349
167Aplasia/Hypoplasia of the patella (HP:0006498)1.51214586
168Low anterior hairline (HP:0000294)1.50859767
169Oligodactyly (HP:0012165)1.50657755
170Broad hallux (HP:0010055)1.50244323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.77402634
2MAP3K104.10944728
3PRPF4B4.09505980
4EEF2K3.80235809
5SMG13.44422244
6TRIB33.17533020
7PKN22.69439440
8ERN12.37275536
9CDC72.34838404
10MAP4K12.34240438
11ICK2.27781095
12NEK22.12158853
13BRD42.07042126
14RIPK42.05099605
15MAP3K131.94510623
16STK101.83198789
17PASK1.79295996
18ALK1.60885521
19CDK41.55168035
20PAK41.51668599
21PTK61.45570072
22SIK31.43043292
23MARK21.42673496
24MTOR1.41931285
25SIK21.41853813
26SIK11.34552672
27CDK71.33095921
28CDK61.30846939
29GRK61.28933982
30RPS6KB21.28901910
31RPS6KA41.26183595
32MAP3K141.25784030
33BMX1.18387406
34KSR21.16935882
35LRRK21.14993713
36PDGFRA1.14431728
37TSSK61.10912828
38TNK21.08824717
39TTN1.07366194
40TYK21.07286583
41IRAK41.06780098
42DMPK1.04258000
43TYRO31.00408156
44MAP3K81.00374718
45BUB10.98665351
46IRAK30.96026476
47CHEK10.95949377
48ATR0.94718385
49WEE10.91756268
50TESK20.91521721
51TTK0.91242848
52MAP3K10.89490516
53PAK20.87324660
54BTK0.86902499
55FGFR30.86231033
56FGFR40.85372684
57FES0.83933627
58CAMK1G0.83481841
59SCYL20.83461098
60STK30.82197668
61CLK10.79773995
62PRKD30.78520881
63MAP2K20.78057800
64CAMK1D0.77849297
65FGFR10.76768370
66TAOK10.76289694
67ZAP700.74717096
68NEK10.74401026
69CAMKK10.74144052
70PDPK10.73961350
71RIPK10.73812743
72* CDK20.73017626
73HIPK20.71538799
74JAK30.70840901
75CHUK0.70766357
76TBK10.70022954
77PIM10.68603740
78MAP3K30.68589401
79IRAK20.68387690
80CDK90.68371199
81LATS10.68367110
82RPS6KL10.67849856
83DYRK30.67681575
84FLT30.66692487
85MKNK10.66555565
86PDK10.65267900
87PDGFRB0.63787893
88MELK0.63437654
89ITK0.63260314
90MAP3K70.62792626
91CSF1R0.62501257
92MAP2K30.62020874
93PLK10.61433760
94SGK30.61295162
95EPHA20.60666224
96CSK0.60508881
97MAP3K110.60501823
98MAPK120.60431802
99PTK20.60192554
100EPHB10.60106808
101DYRK1B0.58714278
102RET0.58103310
103RPS6KA20.57956653
104BLK0.57381930
105MKNK20.57312785
106HCK0.57017299
107JAK10.56701618
108MAPKAPK30.56336602
109ATM0.56325470
110AURKB0.56204927
111STK40.56072486
112RPS6KA10.55875089
113TGFBR10.55657930
114MAPK70.55502116
115IKBKE0.51251138
116MARK30.50646971
117MAPK110.49548358
118LATS20.48447453
119AKT20.47722426
120PRKD20.47241087
121CDC42BPA0.47050987
122PRKCH0.46993183
123STK380.46495081
124TAOK20.46203613
125CDK10.45836713
126CHEK20.44888702
127MAPK100.44270140
128KSR10.44237682
129SYK0.43734876
130LCK0.42972218
131MAPK10.42152035
132MAPKAPK20.42020742
133NME20.40521308
134ARAF0.40208877
135* MAPK140.40077220
136JAK20.39563983
137MAP3K90.38940699
138DDR20.38940664
139BRSK10.38807667
140RPS6KA60.36857206
141RPS6KC10.36514452

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.63478339
2Spliceosome_Homo sapiens_hsa030402.50834590
3mRNA surveillance pathway_Homo sapiens_hsa030152.16913899
4RNA transport_Homo sapiens_hsa030132.08933560
5Notch signaling pathway_Homo sapiens_hsa043302.00631268
6Chronic myeloid leukemia_Homo sapiens_hsa052202.00049654
7Cell cycle_Homo sapiens_hsa041101.98800765
8Base excision repair_Homo sapiens_hsa034101.93019921
9Mismatch repair_Homo sapiens_hsa034301.87068631
10Lysine degradation_Homo sapiens_hsa003101.77522177
11One carbon pool by folate_Homo sapiens_hsa006701.70754727
12MicroRNAs in cancer_Homo sapiens_hsa052061.59649224
13B cell receptor signaling pathway_Homo sapiens_hsa046621.58221222
14Acute myeloid leukemia_Homo sapiens_hsa052211.57326160
15Primary immunodeficiency_Homo sapiens_hsa053401.53141575
16Basal cell carcinoma_Homo sapiens_hsa052171.51541224
17Other glycan degradation_Homo sapiens_hsa005111.51286312
18HTLV-I infection_Homo sapiens_hsa051661.47494321
19Small cell lung cancer_Homo sapiens_hsa052221.46932260
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46173544
21mTOR signaling pathway_Homo sapiens_hsa041501.38733338
22Colorectal cancer_Homo sapiens_hsa052101.36553020
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36168597
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33912416
25Antigen processing and presentation_Homo sapiens_hsa046121.32256059
26Non-small cell lung cancer_Homo sapiens_hsa052231.30359708
27Adherens junction_Homo sapiens_hsa045201.25334279
28T cell receptor signaling pathway_Homo sapiens_hsa046601.24823105
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23199260
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22775518
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22541349
32Proteoglycans in cancer_Homo sapiens_hsa052051.21025309
33Hippo signaling pathway_Homo sapiens_hsa043901.19917346
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19330986
35Choline metabolism in cancer_Homo sapiens_hsa052311.19061421
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18290680
37Herpes simplex infection_Homo sapiens_hsa051681.17464559
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17250579
39Non-homologous end-joining_Homo sapiens_hsa034501.16241977
40Hepatitis B_Homo sapiens_hsa051611.15836314
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15406297
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.14794603
43Bladder cancer_Homo sapiens_hsa052191.14703766
44Viral carcinogenesis_Homo sapiens_hsa052031.14238308
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12945927
46Pancreatic cancer_Homo sapiens_hsa052121.12315868
47Viral myocarditis_Homo sapiens_hsa054161.10842332
48p53 signaling pathway_Homo sapiens_hsa041151.10213688
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.08117089
50Thyroid cancer_Homo sapiens_hsa052161.06789227
51Endometrial cancer_Homo sapiens_hsa052131.06401944
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.05087364
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05063732
54VEGF signaling pathway_Homo sapiens_hsa043701.03702526
55Inositol phosphate metabolism_Homo sapiens_hsa005621.03331052
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01918900
57Osteoclast differentiation_Homo sapiens_hsa043801.01810423
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01495559
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01304735
60Hepatitis C_Homo sapiens_hsa051601.01100118
61Epstein-Barr virus infection_Homo sapiens_hsa051690.98948770
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.96839511
63Prion diseases_Homo sapiens_hsa050200.96643890
64Leishmaniasis_Homo sapiens_hsa051400.96624706
65GnRH signaling pathway_Homo sapiens_hsa049120.96403495
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.95784126
67Long-term potentiation_Homo sapiens_hsa047200.95549392
68Dorso-ventral axis formation_Homo sapiens_hsa043200.94017088
69Hedgehog signaling pathway_Homo sapiens_hsa043400.93053839
70Shigellosis_Homo sapiens_hsa051310.92731036
71Homologous recombination_Homo sapiens_hsa034400.92335208
72Nucleotide excision repair_Homo sapiens_hsa034200.91621282
73Prostate cancer_Homo sapiens_hsa052150.90874153
74Allograft rejection_Homo sapiens_hsa053300.90287381
75Measles_Homo sapiens_hsa051620.90030513
76Renal cell carcinoma_Homo sapiens_hsa052110.89970475
77RNA degradation_Homo sapiens_hsa030180.89287732
78Toxoplasmosis_Homo sapiens_hsa051450.88281865
79Autoimmune thyroid disease_Homo sapiens_hsa053200.88167423
80Apoptosis_Homo sapiens_hsa042100.87411192
81Pathways in cancer_Homo sapiens_hsa052000.86986958
82Tuberculosis_Homo sapiens_hsa051520.85449745
83Focal adhesion_Homo sapiens_hsa045100.83146216
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82336327
85Wnt signaling pathway_Homo sapiens_hsa043100.81512717
86Glioma_Homo sapiens_hsa052140.81284603
87Graft-versus-host disease_Homo sapiens_hsa053320.80242946
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78306308
89Oocyte meiosis_Homo sapiens_hsa041140.78191479
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78141036
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77865791
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.76622041
93Insulin resistance_Homo sapiens_hsa049310.76554629
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.76236162
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73887123
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73478336
97Fanconi anemia pathway_Homo sapiens_hsa034600.73154577
98Prolactin signaling pathway_Homo sapiens_hsa049170.72665809
99Type II diabetes mellitus_Homo sapiens_hsa049300.71463249
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70294249
101TGF-beta signaling pathway_Homo sapiens_hsa043500.69901133
102HIF-1 signaling pathway_Homo sapiens_hsa040660.69609454
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69283487
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68895861
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68353768
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.68166650
107Platelet activation_Homo sapiens_hsa046110.67820107
108Influenza A_Homo sapiens_hsa051640.67062394
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65881457
110FoxO signaling pathway_Homo sapiens_hsa040680.63724282
111Estrogen signaling pathway_Homo sapiens_hsa049150.63151196
112AMPK signaling pathway_Homo sapiens_hsa041520.62299159
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61425789
114Amoebiasis_Homo sapiens_hsa051460.60326138
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60000744
116ErbB signaling pathway_Homo sapiens_hsa040120.57250089
117Insulin signaling pathway_Homo sapiens_hsa049100.55876264
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.55793464
119Legionellosis_Homo sapiens_hsa051340.55726936
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55680774
121MAPK signaling pathway_Homo sapiens_hsa040100.55379552
122TNF signaling pathway_Homo sapiens_hsa046680.54220267
123Pentose phosphate pathway_Homo sapiens_hsa000300.53471098
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53156317
125Hematopoietic cell lineage_Homo sapiens_hsa046400.51921968
126Chemokine signaling pathway_Homo sapiens_hsa040620.51323000
127Endocytosis_Homo sapiens_hsa041440.49609720
128Ribosome_Homo sapiens_hsa030100.49590889
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48263432
130Rap1 signaling pathway_Homo sapiens_hsa040150.47251868

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