SF3A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.40978359
2negative regulation of erythrocyte differentiation (GO:0045647)4.73609676
3protein localization to kinetochore (GO:0034501)4.51101386
4nuclear pore organization (GO:0006999)4.23066845
53-UTR-mediated mRNA stabilization (GO:0070935)4.21784275
6mitotic nuclear envelope disassembly (GO:0007077)4.10396483
7pre-miRNA processing (GO:0031054)4.09496166
8DNA replication initiation (GO:0006270)4.09441392
9nuclear pore complex assembly (GO:0051292)4.08788227
10DNA strand elongation involved in DNA replication (GO:0006271)4.08098832
11mitotic sister chromatid segregation (GO:0000070)4.02641350
12regulation of RNA export from nucleus (GO:0046831)3.97850695
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.93813491
14sister chromatid segregation (GO:0000819)3.92802276
15DNA strand elongation (GO:0022616)3.84348077
16membrane disassembly (GO:0030397)3.82855193
17nuclear envelope disassembly (GO:0051081)3.82855193
18DNA replication-dependent nucleosome organization (GO:0034723)3.75620736
19DNA replication-dependent nucleosome assembly (GO:0006335)3.75620736
20protein localization to chromosome, centromeric region (GO:0071459)3.74514477
21telomere maintenance via semi-conservative replication (GO:0032201)3.71955182
22mitotic metaphase plate congression (GO:0007080)3.68834981
23DNA duplex unwinding (GO:0032508)3.66319019
24folic acid-containing compound biosynthetic process (GO:0009396)3.63935422
25negative regulation of RNA splicing (GO:0033119)3.63113940
26DNA geometric change (GO:0032392)3.63051832
27regulation of nucleobase-containing compound transport (GO:0032239)3.60336025
28RNA stabilization (GO:0043489)3.58529094
29mRNA stabilization (GO:0048255)3.58529094
30regulation of histone H3-K27 methylation (GO:0061085)3.57069758
31formation of translation preinitiation complex (GO:0001731)3.55222401
32IMP biosynthetic process (GO:0006188)3.53344268
33heterochromatin organization (GO:0070828)3.47384984
34maturation of SSU-rRNA (GO:0030490)3.45969528
35mitotic chromosome condensation (GO:0007076)3.44647421
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.43575545
37negative regulation of histone methylation (GO:0031061)3.42187106
38regulation of chromatin binding (GO:0035561)3.40942195
39negative regulation of mRNA processing (GO:0050686)3.39561298
40regulation of NFAT protein import into nucleus (GO:0051532)3.39277513
41ribosomal small subunit biogenesis (GO:0042274)3.37220948
42peptidyl-arginine omega-N-methylation (GO:0035247)3.35992677
43regulation of posttranscriptional gene silencing (GO:0060147)3.35829502
44regulation of gene silencing by miRNA (GO:0060964)3.35829502
45regulation of gene silencing by RNA (GO:0060966)3.35829502
46mitotic recombination (GO:0006312)3.34015000
47DNA replication checkpoint (GO:0000076)3.33833335
48metaphase plate congression (GO:0051310)3.32648146
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28599385
50regulation of spindle organization (GO:0090224)3.27317297
51telomere maintenance via recombination (GO:0000722)3.26117550
52regulation of translational fidelity (GO:0006450)3.22814185
53nucleobase biosynthetic process (GO:0046112)3.22708584
54thymic T cell selection (GO:0045061)3.21479795
55dosage compensation (GO:0007549)3.20173425
56positive regulation of gamma-delta T cell activation (GO:0046645)3.18730394
57positive regulation of chromosome segregation (GO:0051984)3.17877997
58mitotic sister chromatid cohesion (GO:0007064)3.17444098
59negative regulation of mRNA metabolic process (GO:1903312)3.17104889
60pore complex assembly (GO:0046931)3.16783417
61ribosomal small subunit assembly (GO:0000028)3.15953610
62telomere maintenance via telomere lengthening (GO:0010833)3.14857009
63spliceosomal tri-snRNP complex assembly (GO:0000244)3.12430497
64kinetochore organization (GO:0051383)3.12199728
65positive thymic T cell selection (GO:0045059)3.12176659
66* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.11877447
67* mRNA splicing, via spliceosome (GO:0000398)3.11877447
68* RNA splicing, via transesterification reactions (GO:0000375)3.11058689
69regulation of histone H3-K9 methylation (GO:0051570)3.09920162
70intracellular estrogen receptor signaling pathway (GO:0030520)3.09855426
71regulation of sister chromatid cohesion (GO:0007063)3.08693761
72viral transcription (GO:0019083)3.08224839
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.08063140
74negative regulation of chromosome segregation (GO:0051985)3.06081318
75regulation of mammary gland epithelial cell proliferation (GO:0033599)3.03821665
76translational termination (GO:0006415)3.03286484
77nuclear envelope organization (GO:0006998)3.01681505
78apoptotic process involved in morphogenesis (GO:0060561)3.01239645
79paraxial mesoderm development (GO:0048339)3.01071396
80translesion synthesis (GO:0019985)2.99449825
81regulation of chromosome segregation (GO:0051983)2.98314393
82IMP metabolic process (GO:0046040)2.98092247
83attachment of spindle microtubules to kinetochore (GO:0008608)2.97561127
84establishment of chromosome localization (GO:0051303)2.97239524
85spindle assembly checkpoint (GO:0071173)2.96884957
86DNA conformation change (GO:0071103)2.96658578
87negative regulation of mitotic sister chromatid separation (GO:2000816)2.96472511
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96472511
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96472511
90negative regulation of sister chromatid segregation (GO:0033046)2.96472511
91mitotic spindle assembly checkpoint (GO:0007094)2.96241262
92DNA replication-independent nucleosome organization (GO:0034724)2.94789500
93DNA replication-independent nucleosome assembly (GO:0006336)2.94789500
94chromatin assembly or disassembly (GO:0006333)2.94718548
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94424282
96peptidyl-arginine methylation (GO:0018216)2.94098451
97peptidyl-arginine N-methylation (GO:0035246)2.94098451
98histone arginine methylation (GO:0034969)2.93090911
99protein localization to chromosome (GO:0034502)2.92641958
100histone H3-K36 demethylation (GO:0070544)2.92471766
101cellular response to interleukin-4 (GO:0071353)2.92088691
102chromatin assembly (GO:0031497)2.91708216
103DNA topological change (GO:0006265)2.90091735
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90088301
105translational initiation (GO:0006413)2.89972967
106ribosomal large subunit biogenesis (GO:0042273)2.89750638
107ribosome biogenesis (GO:0042254)2.89575816
108spliceosomal snRNP assembly (GO:0000387)2.88589288
109regulation of mitotic spindle organization (GO:0060236)2.88483355
110ribosome assembly (GO:0042255)2.88261298
111protein-DNA complex disassembly (GO:0032986)2.87785092
112nucleosome disassembly (GO:0006337)2.87785092
113alternative mRNA splicing, via spliceosome (GO:0000380)2.87537396
114antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87389356
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87385390
116spindle checkpoint (GO:0031577)2.87136781
117chromosome condensation (GO:0030261)2.87055663
118histone H4-K12 acetylation (GO:0043983)2.86869083
119mitotic spindle checkpoint (GO:0071174)2.85896397
120ATP-dependent chromatin remodeling (GO:0043044)2.85124515
121modulation by virus of host process (GO:0019054)2.82940399
122protein export from nucleus (GO:0006611)2.78759750
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78491171
124negative regulation of cell killing (GO:0031342)2.78491171
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77050856
126trophectodermal cell differentiation (GO:0001829)2.75061538
127protein complex localization (GO:0031503)2.72299926
128embryonic process involved in female pregnancy (GO:0060136)2.71881347
129cellular protein complex localization (GO:0034629)2.68130486
130cellular response to epidermal growth factor stimulus (GO:0071364)2.67646021
131cellular hyperosmotic response (GO:0071474)2.66947239
132adherens junction assembly (GO:0034333)2.65555507
133negative thymic T cell selection (GO:0045060)2.65323331
134response to interleukin-4 (GO:0070670)2.64070740
135antigen processing and presentation of endogenous antigen (GO:0019883)2.62130244
136glucocorticoid receptor signaling pathway (GO:0042921)2.61560161
137modulation by symbiont of host cellular process (GO:0044068)2.61400266
138regulation of early endosome to late endosome transport (GO:2000641)2.59718515
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59167181
140positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.57291008
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.55732059
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.55732059
143modulation by symbiont of host immune response (GO:0052553)2.55732059
144positive regulation by symbiont of host defense response (GO:0052509)2.55732059
145modulation by symbiont of host defense response (GO:0052031)2.55732059
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55732059
147NIK/NF-kappaB signaling (GO:0038061)2.55562185
148regulation of mRNA stability (GO:0043488)2.54863693
149focal adhesion assembly (GO:0048041)2.52994365
150cell-substrate adherens junction assembly (GO:0007045)2.52994365
151T cell selection (GO:0045058)2.52167644
152regulation of gamma-delta T cell differentiation (GO:0045586)2.51479213
153pentose-phosphate shunt (GO:0006098)2.51298123
154response to muramyl dipeptide (GO:0032495)2.50427059
155regulation of RNA stability (GO:0043487)2.49986962
156regulation of translational termination (GO:0006449)2.49692144
157protein localization to endosome (GO:0036010)2.48783696
158Golgi transport vesicle coating (GO:0048200)2.48509815
159COPI coating of Golgi vesicle (GO:0048205)2.48509815
160negative T cell selection (GO:0043383)2.46639997
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46359874
162regulation of gamma-delta T cell activation (GO:0046643)2.45868918
163leukocyte aggregation (GO:0070486)2.45195511
164activation of Rac GTPase activity (GO:0032863)2.44419114
165response to laminar fluid shear stress (GO:0034616)2.43967959
166maternal placenta development (GO:0001893)2.43113731
167DNA packaging (GO:0006323)2.41456741
168positive regulation of gene expression, epigenetic (GO:0045815)2.40810955
169positive regulation by host of viral transcription (GO:0043923)2.39461601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.22612462
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.32679383
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.89410862
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75834661
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43948434
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43013171
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08929549
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.93304820
9MYC_22102868_ChIP-Seq_BL_Human2.69116124
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56266810
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35795209
12XRN2_22483619_ChIP-Seq_HELA_Human2.35389609
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33873427
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14022650
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13287698
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.10215582
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.08313796
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06518575
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06348628
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.06163468
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.05893767
22CIITA_25753668_ChIP-Seq_RAJI_Human2.04714216
23LXR_22292898_ChIP-Seq_THP-1_Human1.99943702
24AR_21909140_ChIP-Seq_LNCAP_Human1.98430838
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.95463659
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90161878
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87572379
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83789361
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81807658
30MAF_26560356_Chip-Seq_TH1_Human1.81367417
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78916975
32TTF2_22483619_ChIP-Seq_HELA_Human1.72543914
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71288967
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69916748
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68203093
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68050787
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.67279567
38VDR_24763502_ChIP-Seq_THP-1_Human1.66160518
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66048081
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64821489
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64037243
42VDR_21846776_ChIP-Seq_THP-1_Human1.61805209
43* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61423830
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59666899
45RACK7_27058665_Chip-Seq_MCF-7_Human1.59219754
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57898136
47FOXP3_21729870_ChIP-Seq_TREG_Human1.57329793
48* VDR_23849224_ChIP-Seq_CD4+_Human1.55328656
49* GABP_19822575_ChIP-Seq_HepG2_Human1.53673007
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.53610274
51MAF_26560356_Chip-Seq_TH2_Human1.53567898
52KDM5A_27292631_Chip-Seq_BREAST_Human1.51067644
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49009900
54DCP1A_22483619_ChIP-Seq_HELA_Human1.48766902
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47969857
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44316084
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.44151851
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44080350
59* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43981210
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43092323
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41913090
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.41849456
63NCOR1_26117541_ChIP-Seq_K562_Human1.41663804
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41046722
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.40227446
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37104476
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36709430
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36438186
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33478935
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32350691
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32226611
72KDM2B_26808549_Chip-Seq_K562_Human1.32173738
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30124827
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30086194
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29326677
76* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26559333
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26418639
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.26180344
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25784594
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25193704
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24905681
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22205286
83* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21760011
84P68_20966046_ChIP-Seq_HELA_Human1.21246840
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.20107001
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19915436
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19793095
88* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18381856
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18143407
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18088495
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.16199835
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16002282
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15463191
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14879093
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14003313
96MYB_26560356_Chip-Seq_TH1_Human1.13874952
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13461732
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13161297
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.12743155
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12620807
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12133126
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11008942
103* TET1_21451524_ChIP-Seq_MESCs_Mouse1.10796425
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10716049
105TFEB_21752829_ChIP-Seq_HELA_Human1.10537814
106TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09902606
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09336027
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09336027
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09336027
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08538073
111CLOCK_20551151_ChIP-Seq_293T_Human1.08293472
112ZNF263_19887448_ChIP-Seq_K562_Human1.08255518
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07536711
114TCF7_22412390_ChIP-Seq_EML_Mouse1.06156224
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.05661272
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04589973
117STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04403476
118* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04348191
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04229267
120SPI1_23547873_ChIP-Seq_NB4_Human1.03515075
121* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03083215
122CREB1_26743006_Chip-Seq_LNCaP_Human1.02412477
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01319234
124MYB_26560356_Chip-Seq_TH2_Human1.01043161
125SCL_19346495_ChIP-Seq_HPC-7_Human1.00622005
126STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00187986
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99794650
128SMC4_20622854_ChIP-Seq_HELA_Human0.99718770
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98807184
130ELK1_19687146_ChIP-ChIP_HELA_Human0.98692491
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98457701
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98401657
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97981495
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97542279
135FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97140518
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97131943
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96511436
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96168640
139SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95907662
140ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95380321
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95122046
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94250731
143UTX_26944678_Chip-Seq_JUKART_Human0.93920224
144KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93617835
145HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93307025
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92757759
147KDM2B_26808549_Chip-Seq_DND41_Human0.91573462
148SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90015045
149PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87820590
150TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87764103
151CHD1_26751641_Chip-Seq_LNCaP_Human0.86423296
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85939806
153OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85695682
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85669067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.05661764
2MP0003111_abnormal_nucleus_morphology4.00817666
3MP0003693_abnormal_embryo_hatching3.93027309
4MP0004957_abnormal_blastocyst_morpholog3.73054649
5MP0003077_abnormal_cell_cycle3.65443590
6MP0008057_abnormal_DNA_replication3.44752042
7MP0003123_paternal_imprinting2.87765109
8MP0005451_abnormal_body_composition2.77158383
9MP0008007_abnormal_cellular_replicative2.47299604
10MP0002877_abnormal_melanocyte_morpholog2.45397170
11MP0008058_abnormal_DNA_repair2.45202884
12MP0001730_embryonic_growth_arrest2.44201379
13MP0003303_peritoneal_inflammation2.41394326
14MP0000350_abnormal_cell_proliferation2.36775834
15MP0008932_abnormal_embryonic_tissue2.28982683
16MP0010030_abnormal_orbit_morphology2.28073146
17MP0010352_gastrointestinal_tract_polyps2.26812947
18MP0003436_decreased_susceptibility_to2.16874295
19MP0005076_abnormal_cell_differentiation2.01337648
20MP0005380_embryogenesis_phenotype2.01162852
21MP0001672_abnormal_embryogenesis/_devel2.01162852
22MP0003300_gastrointestinal_ulcer1.99960700
23MP0002085_abnormal_embryonic_tissue1.94945983
24MP0002084_abnormal_developmental_patter1.93165001
25MP0008877_abnormal_DNA_methylation1.92665057
26MP0003121_genomic_imprinting1.91349893
27MP0002396_abnormal_hematopoietic_system1.91348463
28MP0001697_abnormal_embryo_size1.90172827
29MP0008260_abnormal_autophagy1.90085403
30MP0004197_abnormal_fetal_growth/weight/1.88269463
31MP0004185_abnormal_adipocyte_glucose1.86123965
32MP0003984_embryonic_growth_retardation1.83659833
33MP0000537_abnormal_urethra_morphology1.83510096
34MP0002088_abnormal_embryonic_growth/wei1.81623495
35MP0010307_abnormal_tumor_latency1.81378442
36MP0003890_abnormal_embryonic-extraembry1.79666122
37MP0004808_abnormal_hematopoietic_stem1.71744730
38MP0003283_abnormal_digestive_organ1.71210551
39MP0002796_impaired_skin_barrier1.67794452
40MP0002080_prenatal_lethality1.66766680
41MP0000678_abnormal_parathyroid_gland1.64844702
42MP0003119_abnormal_digestive_system1.64734635
43MP0004947_skin_inflammation1.64039996
44MP0002086_abnormal_extraembryonic_tissu1.62599538
45MP0001348_abnormal_lacrimal_gland1.59480620
46MP0009278_abnormal_bone_marrow1.57883401
47MP0009053_abnormal_anal_canal1.55598263
48MP0003091_abnormal_cell_migration1.52182975
49MP0003453_abnormal_keratinocyte_physiol1.51930442
50MP0001293_anophthalmia1.50558193
51MP0002009_preneoplasia1.50468761
52MP0000490_abnormal_crypts_of1.48641108
53MP0003567_abnormal_fetal_cardiomyocyte1.41913624
54MP0001835_abnormal_antigen_presentation1.40373011
55MP0001849_ear_inflammation1.40219767
56MP0000685_abnormal_immune_system1.39843452
57MP0000858_altered_metastatic_potential1.38944210
58MP0002653_abnormal_ependyma_morphology1.38383655
59MP0003786_premature_aging1.37007834
60MP0003172_abnormal_lysosome_physiology1.36293147
61MP0004381_abnormal_hair_follicle1.34080624
62MP0000313_abnormal_cell_death1.33977376
63MP0004133_heterotaxia1.30965762
64MP0004858_abnormal_nervous_system1.30392526
65MP0005623_abnormal_meninges_morphology1.29772308
66MP0005000_abnormal_immune_tolerance1.27811775
67MP0001800_abnormal_humoral_immune1.27400702
68MP0003705_abnormal_hypodermis_morpholog1.26743659
69MP0002420_abnormal_adaptive_immunity1.24962177
70MP0002429_abnormal_blood_cell1.24877309
71MP0005666_abnormal_adipose_tissue1.23683462
72MP0001819_abnormal_immune_cell1.22846636
73MP0000716_abnormal_immune_system1.21944873
74MP0005501_abnormal_skin_physiology1.21218444
75MP0000703_abnormal_thymus_morphology1.20547726
76MP0001790_abnormal_immune_system1.20062862
77MP0005387_immune_system_phenotype1.20062862
78MP0000428_abnormal_craniofacial_morphol1.17656297
79MP0005058_abnormal_lysosome_morphology1.16613699
80MP0002019_abnormal_tumor_incidence1.16237916
81MP0000689_abnormal_spleen_morphology1.11534837
82MP0005409_darkened_coat_color1.11374105
83MP0003941_abnormal_skin_development1.10830662
84MP0005025_abnormal_response_to1.09695293
85MP0000733_abnormal_muscle_development1.09496508
86MP0002723_abnormal_immune_serum1.09008640
87MP0005464_abnormal_platelet_physiology1.07830862
88MP0002452_abnormal_antigen_presenting1.07676619
89MP0003115_abnormal_respiratory_system1.06986336
90MP0001873_stomach_inflammation1.06924151
91MP0005671_abnormal_response_to1.06552335
92MP0002111_abnormal_tail_morphology1.06523947
93MP0002405_respiratory_system_inflammati1.04806754
94MP0003315_abnormal_perineum_morphology1.03481829
95MP0009672_abnormal_birth_weight1.03360703
96MP0001851_eye_inflammation1.03056730
97MP0002419_abnormal_innate_immunity1.02922991
98MP0002166_altered_tumor_susceptibility1.02529995
99MP0003861_abnormal_nervous_system1.02234136
100MP0003937_abnormal_limbs/digits/tail_de1.01916146
101MP0002132_abnormal_respiratory_system1.01741829
102MP0005397_hematopoietic_system_phenotyp0.99606084
103MP0001545_abnormal_hematopoietic_system0.99606084
104MP0003935_abnormal_craniofacial_develop0.98481197
105MP0004264_abnormal_extraembryonic_tissu0.98322540
106MP0002210_abnormal_sex_determination0.97132587
107MP0003122_maternal_imprinting0.96944301
108MP0009703_decreased_birth_body0.94688235
109MP0010234_abnormal_vibrissa_follicle0.94552424
110MP0002092_abnormal_eye_morphology0.93965518
111MP0004233_abnormal_muscle_weight0.93470117
112MP0002932_abnormal_joint_morphology0.91803949
113MP0008961_abnormal_basal_metabolism0.91516341
114MP0002697_abnormal_eye_size0.90718528
115MP0010630_abnormal_cardiac_muscle0.89238704
116MP0003828_pulmonary_edema0.88910410
117MP0001145_abnormal_male_reproductive0.88898348
118MP0001346_abnormal_lacrimal_gland0.88602111
119MP0001915_intracranial_hemorrhage0.88416906
120MP0000432_abnormal_head_morphology0.87594700
121MP0000049_abnormal_middle_ear0.87160365
122MP0003763_abnormal_thymus_physiology0.86889799
123MP0002398_abnormal_bone_marrow0.86533292
124MP0005375_adipose_tissue_phenotype0.86389490
125MP0009333_abnormal_splenocyte_physiolog0.85674976
126MP0005023_abnormal_wound_healing0.85633860
127MP0002925_abnormal_cardiovascular_devel0.85417306
128MP0010155_abnormal_intestine_physiology0.84656735
129MP0001286_abnormal_eye_development0.84527631
130MP0003566_abnormal_cell_adhesion0.83456403
131MP0002089_abnormal_postnatal_growth/wei0.83127315
132MP0003385_abnormal_body_wall0.80758024
133MP0002722_abnormal_immune_system0.80268519
134MP0003942_abnormal_urinary_system0.79269633
135MP0002116_abnormal_craniofacial_bone0.78329964
136MP0008789_abnormal_olfactory_epithelium0.76755315
137MP0003787_abnormal_imprinting0.75129276
138MP0003755_abnormal_palate_morphology0.73910075
139MP0008770_decreased_survivor_rate0.73841524
140MP0002114_abnormal_axial_skeleton0.73418604
141MP0003943_abnormal_hepatobiliary_system0.72564896
142MP0006292_abnormal_olfactory_placode0.71892452
143MP0002282_abnormal_trachea_morphology0.71685053
144MP0005384_cellular_phenotype0.71232384
145MP0005621_abnormal_cell_physiology0.70861654
146MP0001929_abnormal_gametogenesis0.69135576
147MP0000653_abnormal_sex_gland0.68317178
148MP0002075_abnormal_coat/hair_pigmentati0.67820276
149MP0005499_abnormal_olfactory_system0.67349055
150MP0005394_taste/olfaction_phenotype0.67349055
151MP0002938_white_spotting0.66995171
152MP0002102_abnormal_ear_morphology0.66427959
153MP0002081_perinatal_lethality0.66102768
154MP0002249_abnormal_larynx_morphology0.66058043

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.67827402
2Selective tooth agenesis (HP:0001592)3.26398675
3Colon cancer (HP:0003003)3.19529995
4Medulloblastoma (HP:0002885)3.19497121
5Increased nuchal translucency (HP:0010880)3.13091224
6Abnormal number of incisors (HP:0011064)3.12343170
7Reticulocytopenia (HP:0001896)3.11715043
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.99731199
9Short 4th metacarpal (HP:0010044)2.99731199
10Patellar aplasia (HP:0006443)2.94434805
11Renal duplication (HP:0000075)2.93377171
12Hyperacusis (HP:0010780)2.91154293
13Urethral obstruction (HP:0000796)2.86628140
14Obstructive sleep apnea (HP:0002870)2.79472560
15Birth length less than 3rd percentile (HP:0003561)2.78995150
16Aplasia/Hypoplasia of the patella (HP:0006498)2.76844722
17Abnormality of the astrocytes (HP:0100707)2.68203736
18Astrocytoma (HP:0009592)2.68203736
19Abnormality of the labia minora (HP:0012880)2.63913882
20Increased connective tissue (HP:0009025)2.63219470
21Degeneration of anterior horn cells (HP:0002398)2.58309765
22Abnormality of the anterior horn cell (HP:0006802)2.58309765
23Progressive muscle weakness (HP:0003323)2.58186895
24Eczematoid dermatitis (HP:0000976)2.56767492
25Insomnia (HP:0100785)2.56448357
26Overlapping toe (HP:0001845)2.55194085
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.54077821
28Long palpebral fissure (HP:0000637)2.53541814
29Proximal placement of thumb (HP:0009623)2.52575723
30Chromsome breakage (HP:0040012)2.51109886
31Cellulitis (HP:0100658)2.48367537
32Deviation of the thumb (HP:0009603)2.47270014
33Deep palmar crease (HP:0006191)2.46573205
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46458094
35Basal cell carcinoma (HP:0002671)2.44388945
36Disproportionate tall stature (HP:0001519)2.43570120
37Missing ribs (HP:0000921)2.43122362
38Rhabdomyosarcoma (HP:0002859)2.42337789
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37326971
40Progressive external ophthalmoplegia (HP:0000590)2.36818847
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.36813681
42Absent thumb (HP:0009777)2.35870351
43Neoplasm of striated muscle (HP:0009728)2.34085110
4411 pairs of ribs (HP:0000878)2.33230498
45Dysmetric saccades (HP:0000641)2.32498706
46Glioma (HP:0009733)2.30827958
47Meckel diverticulum (HP:0002245)2.30396561
48Abnormality of the phalanges of the hallux (HP:0010057)2.28644787
49Long eyelashes (HP:0000527)2.28269070
50Abnormality of the ileum (HP:0001549)2.26890875
51Ectopic kidney (HP:0000086)2.26412757
52Volvulus (HP:0002580)2.25808345
53Abnormality of oral frenula (HP:0000190)2.25550393
54Segmental peripheral demyelination/remyelination (HP:0003481)2.24814831
55Oral leukoplakia (HP:0002745)2.24093121
56Increased IgE level (HP:0003212)2.23615650
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.23431520
58Slow saccadic eye movements (HP:0000514)2.23088386
59Absent radius (HP:0003974)2.22932581
60Abdominal situs inversus (HP:0003363)2.22455279
61Abnormality of abdominal situs (HP:0011620)2.22455279
62Broad face (HP:0000283)2.21922398
63Abnormality of chromosome stability (HP:0003220)2.21261328
64Facial hemangioma (HP:0000329)2.19414179
65Ankyloglossia (HP:0010296)2.17741700
66Atresia of the external auditory canal (HP:0000413)2.17589356
67Breast hypoplasia (HP:0003187)2.16105349
68Duodenal stenosis (HP:0100867)2.14455042
69Small intestinal stenosis (HP:0012848)2.14455042
70Fatigue (HP:0012378)2.14318427
71Abnormality of the 4th metacarpal (HP:0010012)2.14142516
72Distal lower limb amyotrophy (HP:0008944)2.11907422
73Peripheral hypomyelination (HP:0007182)2.11830358
74Broad distal phalanx of finger (HP:0009836)2.10949343
75Myelodysplasia (HP:0002863)2.10748745
76Abnormality of cells of the erythroid lineage (HP:0012130)2.10662042
77Neoplasm of the pancreas (HP:0002894)2.10500914
78Aplasia involving forearm bones (HP:0009822)2.08496915
79Absent forearm bone (HP:0003953)2.08496915
80Neoplasm of the oral cavity (HP:0100649)2.08057990
81Impulsivity (HP:0100710)2.07644785
82Dislocated radial head (HP:0003083)2.05651925
83Ulnar bowing (HP:0003031)2.05021563
84High anterior hairline (HP:0009890)2.04843075
85Aplasia/Hypoplasia of the sternum (HP:0006714)2.04421077
86Recurrent viral infections (HP:0004429)2.04386646
87Metaphyseal cupping (HP:0003021)2.03776319
88Trigonocephaly (HP:0000243)2.03501212
89Achilles tendon contracture (HP:0001771)2.02978872
90Abnormality of the preputium (HP:0100587)2.00990701
91Abnormality of the carotid arteries (HP:0005344)1.99578786
92Bowel incontinence (HP:0002607)1.99106504
93Spinal cord lesions (HP:0100561)1.98888836
94Syringomyelia (HP:0003396)1.98888836
95Rib fusion (HP:0000902)1.98564981
96Cafe-au-lait spot (HP:0000957)1.97626839
97Malignant gastrointestinal tract tumors (HP:0006749)1.97483495
98Gastrointestinal carcinoma (HP:0002672)1.97483495
99Prominent nose (HP:0000448)1.97088172
100Gastrointestinal inflammation (HP:0004386)1.96526800
101Patellar dislocation (HP:0002999)1.96378509
102Broad palm (HP:0001169)1.95487070
103High pitched voice (HP:0001620)1.95161844
104Abnormal lung lobation (HP:0002101)1.94495871
105Abnormal number of erythroid precursors (HP:0012131)1.93925771
106Tracheoesophageal fistula (HP:0002575)1.93852991
107Elfin facies (HP:0004428)1.93076950
108Abnormal gallbladder physiology (HP:0012438)1.93026773
109Cholecystitis (HP:0001082)1.93026773
110Renovascular hypertension (HP:0100817)1.91909188
111Abnormal large intestine physiology (HP:0012700)1.91249855
112Abnormality of the fingertips (HP:0001211)1.90229908
113Overriding aorta (HP:0002623)1.90130612
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.90026924
115Recurrent abscess formation (HP:0002722)1.89532171
116Skull defect (HP:0001362)1.88870857
117Obstructive lung disease (HP:0006536)1.88650178
118Chronic obstructive pulmonary disease (HP:0006510)1.88650178
119Flat acetabular roof (HP:0003180)1.87942247
120Gastrointestinal stroma tumor (HP:0100723)1.87750138
121Abnormality of the radial head (HP:0003995)1.87454166
122Abnormality of skeletal muscle fiber size (HP:0012084)1.87109269
123Colitis (HP:0002583)1.86713327
124Carpal bone hypoplasia (HP:0001498)1.85519668
125Skin tags (HP:0010609)1.84950651
126Abnormality of the thoracic spine (HP:0100711)1.83665965
127Increased variability in muscle fiber diameter (HP:0003557)1.83270571
128Broad thumb (HP:0011304)1.82814304
129Reticulocytosis (HP:0001923)1.82721363
130Hypertensive crisis (HP:0100735)1.81941483
131Supernumerary bones of the axial skeleton (HP:0009144)1.81748603
132Squamous cell carcinoma (HP:0002860)1.81215658
133Megalocornea (HP:0000485)1.80741003
134Supernumerary ribs (HP:0005815)1.80223312
135Agnosia (HP:0010524)1.79722657
136Abnormality of the duodenum (HP:0002246)1.79314166
137Abnormality of the salivary glands (HP:0010286)1.76869520
138Preauricular skin tag (HP:0000384)1.76293034
139Aplasia/Hypoplasia of the thymus (HP:0010515)1.76242036
140Pointed chin (HP:0000307)1.76180116
141Angiofibromas (HP:0010615)1.75445817
142Adenoma sebaceum (HP:0009720)1.75445817
143Cutis marmorata (HP:0000965)1.75342737
144Persistence of primary teeth (HP:0006335)1.75137274
145Abnormality of the columella (HP:0009929)1.74523821
146Pelvic girdle muscle weakness (HP:0003749)1.73731271
147Abnormality of the Achilles tendon (HP:0005109)1.73456972
148Truncus arteriosus (HP:0001660)1.73283999
149Abnormality of the calcaneus (HP:0008364)1.72515526
150Supernumerary spleens (HP:0009799)1.72475331
151Abnormality of the distal phalanges of the toes (HP:0010182)1.71799819
152Ragged-red muscle fibers (HP:0003200)1.71703728
153Aplasia/hypoplasia of the humerus (HP:0006507)1.71554007
154Seborrheic dermatitis (HP:0001051)1.70998131
155Viral hepatitis (HP:0006562)1.70981354
156Meningitis (HP:0001287)1.70863611
157Broad alveolar ridges (HP:0000187)1.70732264
158Trismus (HP:0000211)1.70429664
159Flat cornea (HP:0007720)1.69315912
160Agammaglobulinemia (HP:0004432)1.69234474
161Recurrent bacterial skin infections (HP:0005406)1.68456012
162Bowel diverticulosis (HP:0005222)1.68427767
163Thoracic kyphosis (HP:0002942)1.68147589
164Pseudobulbar signs (HP:0002200)1.67020513
165Esophageal atresia (HP:0002032)1.66884835
166Polygenic inheritance (HP:0010982)1.63927236
167Abnormality of macrophages (HP:0004311)1.63880496
168Progressive hearing impairment (HP:0001730)1.60176731
169Inflammation of the large intestine (HP:0002037)1.59087718
170Abnormality of reticulocytes (HP:0004312)1.59047024
171Difficulty climbing stairs (HP:0003551)1.56528239
172Mediastinal lymphadenopathy (HP:0100721)1.56412627
173Arnold-Chiari malformation (HP:0002308)1.55685399
174Genu recurvatum (HP:0002816)1.55286409
175Premature skin wrinkling (HP:0100678)1.53427635
176Gingivitis (HP:0000230)1.53342631
177Self-mutilation (HP:0000742)1.52539941
178Protrusio acetabuli (HP:0003179)1.52447144
179Sparse lateral eyebrow (HP:0005338)1.52237193
180Abnormality of cells of the lymphoid lineage (HP:0012140)1.50712174
181Annular pancreas (HP:0001734)1.50507058
182Emphysema (HP:0002097)1.50305782
183Obsessive-compulsive behavior (HP:0000722)1.48871949
184Vertebral compression fractures (HP:0002953)1.48221298
185Cerebral aneurysm (HP:0004944)1.48160142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.23512181
2CDK124.18186849
3PRPF4B3.92541335
4SMG13.88601588
5EEF2K3.35812161
6BUB13.28276675
7WEE13.06763404
8NEK22.86340973
9NEK12.79029910
10MAP3K102.72013320
11TTK2.50115157
12TSSK62.33243568
13BRD42.13961060
14PASK2.07292408
15STK101.99639471
16ERN11.99144303
17MAP3K131.92713097
18RIPK41.89980323
19CDK71.89630576
20SIK11.86843643
21RPS6KB21.83768336
22PLK11.79541374
23MKNK11.75374631
24PKN21.73957070
25ATR1.72410441
26CDK41.70896974
27FGFR41.63465593
28KSR21.61683883
29TRIB31.60977395
30SRPK11.56303411
31ALK1.49193353
32IRAK31.45672221
33CHEK11.45536012
34TESK21.42310409
35TAOK11.42220080
36BRSK21.40984060
37AURKB1.40747667
38MAP3K81.38998232
39TGFBR11.38315609
40CHEK21.34983278
41MKNK21.34511625
42SCYL21.33968170
43BRSK11.31043789
44DYRK31.29190271
45PLK31.28521445
46PAK41.23220822
47AURKA1.12568939
48MAP3K11.10254651
49ICK1.10182592
50EIF2AK11.09097181
51NME21.08649665
52RPS6KA41.07798814
53CDK21.07211206
54MAP3K31.06166589
55MTOR1.05589504
56MAP3K141.03641078
57FES1.03335921
58RIPK11.02164463
59MAP3K91.01788506
60IRAK41.01385482
61CDK61.01055018
62MELK0.99731784
63PLK40.97725674
64ATM0.97658565
65EPHB10.96174513
66TYRO30.95080802
67MAP4K10.93586404
68CLK10.92983375
69MARK20.92807282
70TLK10.91815582
71PDGFRA0.91404892
72LRRK20.89194477
73EPHA20.87926128
74HIPK20.85666040
75LATS20.85230407
76STK40.79962641
77CDK10.79502730
78PRKD30.78924886
79CDK80.76365095
80TYK20.76315098
81SIK30.75329629
82ACVR1B0.74276983
83PRKD20.74044407
84PIM10.73857034
85IRAK20.73529653
86CAMK1D0.72054951
87FGFR10.71630355
88CSK0.69160312
89ZAP700.67709333
90MAPK110.67650825
91PTK60.67599957
92KSR10.65959747
93BMX0.65854938
94CDC42BPA0.65604792
95AKT20.62949806
96UHMK10.62771680
97PAK10.62326723
98JAK30.62079185
99PAK20.60783476
100PDPK10.60525032
101BRAF0.60006023
102VRK10.59761476
103MAP2K20.58347788
104CDK90.56603263
105PNCK0.56379481
106ARAF0.56302916
107CSNK2A20.53638955
108MAP2K30.53570548
109HCK0.53465969
110CSNK1E0.51567558
111PRKCI0.48364297
112CAMK1G0.47220310
113VRK20.45461639
114PRKDC0.45408497
115MAPK140.45298522
116PDK10.44325595
117RPS6KA20.44098880
118RAF10.43417974
119STK30.42976007
120GRK60.42908313
121FGFR30.42375623
122SIK20.41863467
123CCNB10.41254139
124TAOK20.40447539
125MARK30.39438095
126RPS6KC10.39163196
127RPS6KL10.39163196
128MOS0.38844116
129RPS6KA10.38815517
130PRKCH0.38804357
131TTN0.38396440
132CSNK2A10.37548687
133MAP3K70.37378849
134RET0.37039999
135AKT10.36245746
136TNK20.36239173
137MAP3K20.35474377
138CSNK1D0.35307977
139TESK10.35148719
140FLT30.34940246
141MAPK100.34864706
142ILK0.34101915
143GSK3B0.32994024
144RPS6KA60.30614646
145MAPK10.29842336
146CDK11A0.29067953
147LATS10.27803041
148MAPKAPK20.27624161
149MAP3K110.27158033
150CHUK0.26058625
151BTK0.25986435

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47889209
2Mismatch repair_Homo sapiens_hsa034303.81068038
3* Spliceosome_Homo sapiens_hsa030403.49133004
4RNA transport_Homo sapiens_hsa030133.19894923
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09943004
6Base excision repair_Homo sapiens_hsa034103.00682591
7Cell cycle_Homo sapiens_hsa041102.90363271
8Homologous recombination_Homo sapiens_hsa034402.57135643
9One carbon pool by folate_Homo sapiens_hsa006702.55587159
10Nucleotide excision repair_Homo sapiens_hsa034202.54304658
11Ribosome_Homo sapiens_hsa030102.42294733
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41721339
13mRNA surveillance pathway_Homo sapiens_hsa030152.36879060
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14035028
15RNA polymerase_Homo sapiens_hsa030202.12535957
16Fanconi anemia pathway_Homo sapiens_hsa034602.00318719
17Non-homologous end-joining_Homo sapiens_hsa034501.73326782
18RNA degradation_Homo sapiens_hsa030181.69919744
19Pyrimidine metabolism_Homo sapiens_hsa002401.68810982
20Basal transcription factors_Homo sapiens_hsa030221.51429946
21p53 signaling pathway_Homo sapiens_hsa041151.49477378
22Proteasome_Homo sapiens_hsa030501.41000957
23Notch signaling pathway_Homo sapiens_hsa043301.36334314
24Basal cell carcinoma_Homo sapiens_hsa052171.34929840
25Osteoclast differentiation_Homo sapiens_hsa043801.30309946
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29569180
27MicroRNAs in cancer_Homo sapiens_hsa052061.27840468
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27094698
29Oocyte meiosis_Homo sapiens_hsa041141.23169128
30Epstein-Barr virus infection_Homo sapiens_hsa051691.22850513
31Viral carcinogenesis_Homo sapiens_hsa052031.18723360
32Chronic myeloid leukemia_Homo sapiens_hsa052201.18166210
33HTLV-I infection_Homo sapiens_hsa051661.17571859
34Hippo signaling pathway_Homo sapiens_hsa043901.15088206
35Leishmaniasis_Homo sapiens_hsa051401.14583518
36Prion diseases_Homo sapiens_hsa050201.10307500
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09493724
38Colorectal cancer_Homo sapiens_hsa052101.08291160
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06370141
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04083858
41Thyroid cancer_Homo sapiens_hsa052161.01438129
42Small cell lung cancer_Homo sapiens_hsa052220.94495179
43Other glycan degradation_Homo sapiens_hsa005110.94291377
44Antigen processing and presentation_Homo sapiens_hsa046120.93853310
45Hedgehog signaling pathway_Homo sapiens_hsa043400.92988887
46Herpes simplex infection_Homo sapiens_hsa051680.92898391
47Insulin signaling pathway_Homo sapiens_hsa049100.92876499
48Hepatitis C_Homo sapiens_hsa051600.87234199
49Choline metabolism in cancer_Homo sapiens_hsa052310.86863937
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86124452
51Toxoplasmosis_Homo sapiens_hsa051450.85586887
52Chemokine signaling pathway_Homo sapiens_hsa040620.82060440
53mTOR signaling pathway_Homo sapiens_hsa041500.82000015
54Non-small cell lung cancer_Homo sapiens_hsa052230.80554194
55Adherens junction_Homo sapiens_hsa045200.79859445
56Inositol phosphate metabolism_Homo sapiens_hsa005620.79527267
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78446774
58Acute myeloid leukemia_Homo sapiens_hsa052210.77721596
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77709664
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77395641
61Systemic lupus erythematosus_Homo sapiens_hsa053220.76967496
62Endometrial cancer_Homo sapiens_hsa052130.76436446
63Purine metabolism_Homo sapiens_hsa002300.75782111
64TNF signaling pathway_Homo sapiens_hsa046680.75211717
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.74753419
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.74741038
67TGF-beta signaling pathway_Homo sapiens_hsa043500.74310497
68Lysine degradation_Homo sapiens_hsa003100.72313847
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69562661
70GnRH signaling pathway_Homo sapiens_hsa049120.69176393
71Wnt signaling pathway_Homo sapiens_hsa043100.68665724
72Bladder cancer_Homo sapiens_hsa052190.67762037
73Hepatitis B_Homo sapiens_hsa051610.66134304
74Long-term potentiation_Homo sapiens_hsa047200.65999817
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65367436
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.65250771
77Pathways in cancer_Homo sapiens_hsa052000.64253192
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.62854849
79Proteoglycans in cancer_Homo sapiens_hsa052050.62355295
80Viral myocarditis_Homo sapiens_hsa054160.61781162
81Biosynthesis of amino acids_Homo sapiens_hsa012300.61565241
82Primary immunodeficiency_Homo sapiens_hsa053400.61457693
83Shigellosis_Homo sapiens_hsa051310.61171879
84Endocytosis_Homo sapiens_hsa041440.59980469
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59206920
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.58462502
87Tuberculosis_Homo sapiens_hsa051520.57649832
88Apoptosis_Homo sapiens_hsa042100.57393458
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57036829
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.56826103
91AMPK signaling pathway_Homo sapiens_hsa041520.56652131
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56316698
93Fructose and mannose metabolism_Homo sapiens_hsa000510.56281225
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54967346
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54838713
96Pancreatic cancer_Homo sapiens_hsa052120.54669459
97HIF-1 signaling pathway_Homo sapiens_hsa040660.54050140
98Prostate cancer_Homo sapiens_hsa052150.53415310
99MAPK signaling pathway_Homo sapiens_hsa040100.51441084
100Platelet activation_Homo sapiens_hsa046110.51069405
101Autoimmune thyroid disease_Homo sapiens_hsa053200.50337547
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45591420
103Alcoholism_Homo sapiens_hsa050340.45408207
104VEGF signaling pathway_Homo sapiens_hsa043700.44948184
105Pentose phosphate pathway_Homo sapiens_hsa000300.43240069
106Glioma_Homo sapiens_hsa052140.42659500
107Legionellosis_Homo sapiens_hsa051340.42488987
108Renal cell carcinoma_Homo sapiens_hsa052110.42070733
109T cell receptor signaling pathway_Homo sapiens_hsa046600.41769152
110B cell receptor signaling pathway_Homo sapiens_hsa046620.40952860
111Tight junction_Homo sapiens_hsa045300.40811799
112Selenocompound metabolism_Homo sapiens_hsa004500.40591533
113Melanoma_Homo sapiens_hsa052180.39374069
114Measles_Homo sapiens_hsa051620.37807209
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37558692
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.36610303
117N-Glycan biosynthesis_Homo sapiens_hsa005100.34717728
118Focal adhesion_Homo sapiens_hsa045100.33607087
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32040271
120Influenza A_Homo sapiens_hsa051640.31611358
121FoxO signaling pathway_Homo sapiens_hsa040680.30552831
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28247967
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27706501
124ErbB signaling pathway_Homo sapiens_hsa040120.25491000
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25299597
126Estrogen signaling pathway_Homo sapiens_hsa049150.25225662
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.25214283
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.23454605
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22388935
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22230084
131Prolactin signaling pathway_Homo sapiens_hsa049170.21998845

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