SF3A3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfur amino acid catabolic process (GO:0000098)6.56711536
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.13401389
3tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.13401389
4folic acid-containing compound biosynthetic process (GO:0009396)5.81647442
5adenosine metabolic process (GO:0046085)4.81364741
6cell wall macromolecule catabolic process (GO:0016998)4.67856999
7epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.67147488
8behavioral response to nicotine (GO:0035095)4.53958827
9cysteine metabolic process (GO:0006534)4.42199032
10homocysteine metabolic process (GO:0050667)4.30632605
11mitochondrial RNA metabolic process (GO:0000959)4.28183665
12microtubule nucleation (GO:0007020)4.16251250
13pseudouridine synthesis (GO:0001522)4.15778227
14purine nucleotide salvage (GO:0032261)4.15708634
15CENP-A containing nucleosome assembly (GO:0034080)3.88700378
16IMP biosynthetic process (GO:0006188)3.84314586
17cell wall macromolecule metabolic process (GO:0044036)3.82453425
18pteridine-containing compound biosynthetic process (GO:0042559)3.77798667
19regulation of plasminogen activation (GO:0010755)3.74385185
20chromatin remodeling at centromere (GO:0031055)3.74233380
21tetrahydrofolate metabolic process (GO:0046653)3.72545965
22transcription from mitochondrial promoter (GO:0006390)3.65664942
23regulation of mitotic spindle checkpoint (GO:1903504)3.56433243
24regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56433243
25galactose catabolic process (GO:0019388)3.46436399
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44734939
27cartilage morphogenesis (GO:0060536)3.44168766
28positive regulation of endothelial cell differentiation (GO:0045603)3.40403645
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.34596561
30NADH dehydrogenase complex assembly (GO:0010257)3.34596561
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34596561
32proteasome assembly (GO:0043248)3.33192635
33preassembly of GPI anchor in ER membrane (GO:0016254)3.32554301
34G-protein coupled receptor internalization (GO:0002031)3.30564649
35folic acid-containing compound metabolic process (GO:0006760)3.28483994
36protein-cofactor linkage (GO:0018065)3.24355464
37primary amino compound metabolic process (GO:1901160)3.23875790
38organelle disassembly (GO:1903008)3.18599083
39rRNA methylation (GO:0031167)3.12032319
40response to folic acid (GO:0051593)3.11090954
41mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.10829950
42protein complex biogenesis (GO:0070271)3.09425679
43white fat cell differentiation (GO:0050872)3.09200332
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08353034
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05453526
46rRNA modification (GO:0000154)3.02559664
47histone exchange (GO:0043486)3.02084091
48tRNA modification (GO:0006400)3.00008832
49energy coupled proton transport, down electrochemical gradient (GO:0015985)2.99574147
50ATP synthesis coupled proton transport (GO:0015986)2.99574147
51sulfur amino acid metabolic process (GO:0000096)2.98413620
52regulation of vitamin D biosynthetic process (GO:0060556)2.96104351
53tRNA processing (GO:0008033)2.94809141
54nucleobase biosynthetic process (GO:0046112)2.92890898
55organic cation transport (GO:0015695)2.91771164
56neuron cell-cell adhesion (GO:0007158)2.91397264
57platelet dense granule organization (GO:0060155)2.90662592
58lung lobe morphogenesis (GO:0060463)2.90361709
59mitochondrial respiratory chain complex assembly (GO:0033108)2.90259717
60negative regulation of DNA biosynthetic process (GO:2000279)2.89742828
61regulation of mesenchymal cell apoptotic process (GO:2001053)2.89008446
62regulation of sequestering of triglyceride (GO:0010889)2.88581608
63respiratory chain complex IV assembly (GO:0008535)2.87004056
64regulation of interleukin-6 biosynthetic process (GO:0045408)2.85092651
65DNA double-strand break processing (GO:0000729)2.78894041
66single strand break repair (GO:0000012)2.78707158
67maturation of 5.8S rRNA (GO:0000460)2.75834999
68water-soluble vitamin biosynthetic process (GO:0042364)2.74842210
69purine nucleobase biosynthetic process (GO:0009113)2.74537937
707-methylguanosine mRNA capping (GO:0006370)2.71765265
71purine-containing compound salvage (GO:0043101)2.71227024
72regulation of endothelial cell differentiation (GO:0045601)2.70929320
73galactose metabolic process (GO:0006012)2.69781118
74signal peptide processing (GO:0006465)2.69433940
75respiratory electron transport chain (GO:0022904)2.67452757
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67437661
77electron transport chain (GO:0022900)2.67011385
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66531366
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66531366
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66531366
81amino acid salvage (GO:0043102)2.66189223
82L-methionine salvage (GO:0071267)2.66189223
83L-methionine biosynthetic process (GO:0071265)2.66189223
84cellular ketone body metabolic process (GO:0046950)2.66027990
85GTP biosynthetic process (GO:0006183)2.65589471
867-methylguanosine RNA capping (GO:0009452)2.64993849
87RNA capping (GO:0036260)2.64993849
88IMP metabolic process (GO:0046040)2.64824835
89regulation of centriole replication (GO:0046599)2.64124346
90positive regulation of meiosis (GO:0045836)2.63868127
91histone mRNA metabolic process (GO:0008334)2.62690510
92pteridine-containing compound metabolic process (GO:0042558)2.62296998
93energy homeostasis (GO:0097009)2.61007096
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60880847
95histone-serine phosphorylation (GO:0035404)2.59255795
96mesenchymal cell proliferation (GO:0010463)2.55990637
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55862225
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55862225
99mRNA splice site selection (GO:0006376)2.55237413
100protein localization to kinetochore (GO:0034501)2.54779774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.88387731
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79614232
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.62608415
4VDR_22108803_ChIP-Seq_LS180_Human3.30710978
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.02047883
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.00039317
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.83951305
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66104692
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59905185
10ZNF274_21170338_ChIP-Seq_K562_Hela2.53274756
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47625942
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.30209986
13E2F7_22180533_ChIP-Seq_HELA_Human2.21759602
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14345133
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01526438
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01469267
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01361825
18EWS_26573619_Chip-Seq_HEK293_Human1.92212605
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86570781
20SUZ12_27294783_Chip-Seq_NPCs_Mouse1.83385502
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80227430
22GBX2_23144817_ChIP-Seq_PC3_Human1.79183010
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73722870
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71265069
25VDR_23849224_ChIP-Seq_CD4+_Human1.71229022
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.71072912
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69147840
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.67613903
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67139333
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64999390
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64927885
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.61688294
33ELK1_19687146_ChIP-ChIP_HELA_Human1.59493595
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.56007682
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52174465
36TP53_22573176_ChIP-Seq_HFKS_Human1.50185519
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49079991
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46035340
39P300_19829295_ChIP-Seq_ESCs_Human1.44119555
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41280341
41MYC_18940864_ChIP-ChIP_HL60_Human1.41256933
42IGF1R_20145208_ChIP-Seq_DFB_Human1.39814499
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39561830
44FOXP3_21729870_ChIP-Seq_TREG_Human1.39497962
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38655562
46NANOG_19829295_ChIP-Seq_ESCs_Human1.36841580
47SOX2_19829295_ChIP-Seq_ESCs_Human1.36841580
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36423974
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36293371
50BCAT_22108803_ChIP-Seq_LS180_Human1.35686103
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.33107178
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31932138
53FUS_26573619_Chip-Seq_HEK293_Human1.31513000
54ER_23166858_ChIP-Seq_MCF-7_Human1.20428561
55HTT_18923047_ChIP-ChIP_STHdh_Human1.20076976
56CDX2_22108803_ChIP-Seq_LS180_Human1.20075088
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20031609
58TCF4_22108803_ChIP-Seq_LS180_Human1.17583002
59STAT3_23295773_ChIP-Seq_U87_Human1.13317866
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12404533
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12351670
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.12351670
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11080681
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.10259843
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.09972301
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09291808
67IRF1_19129219_ChIP-ChIP_H3396_Human1.08624477
68NCOR_22424771_ChIP-Seq_293T_Human1.08535416
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.08035673
70TAF15_26573619_Chip-Seq_HEK293_Human1.07440628
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04304115
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04153938
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03845899
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.01992066
75OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01812719
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.01199786
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.01082918
78AR_20517297_ChIP-Seq_VCAP_Human1.00948500
79P53_22387025_ChIP-Seq_ESCs_Mouse0.98625943
80TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97392563
81MYC_18555785_ChIP-Seq_MESCs_Mouse0.96838320
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96631098
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96083059
84SMAD4_21741376_ChIP-Seq_EPCs_Human0.95093958
85OCT4_18555785_Chip-Seq_ESCs_Mouse0.95085699
86P300_18555785_Chip-Seq_ESCs_Mouse0.93710986
87SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93289678
88SMAD4_21799915_ChIP-Seq_A2780_Human0.91159688
89GABP_19822575_ChIP-Seq_HepG2_Human0.90936758
90CTCF_18555785_Chip-Seq_ESCs_Mouse0.90854082
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90274615
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90126799
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89946492
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89418931
95SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88832504
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.88363036
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88034412
98EZH2_22144423_ChIP-Seq_EOC_Human0.87303780
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86783318
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86536578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence4.12689677
2MP0004885_abnormal_endolymph3.61537416
3MP0005646_abnormal_pituitary_gland3.58008097
4MP0004147_increased_porphyrin_level3.39177468
5MP0005670_abnormal_white_adipose3.26064106
6MP0009697_abnormal_copulation2.93736711
7MP0002938_white_spotting2.89957599
8MP0002234_abnormal_pharynx_morphology2.86419980
9MP0002736_abnormal_nociception_after2.81784195
10MP0003786_premature_aging2.31031214
11MP0001968_abnormal_touch/_nociception2.23254678
12MP0008875_abnormal_xenobiotic_pharmacok2.22912239
13MP0005551_abnormal_eye_electrophysiolog2.14301503
14MP0005167_abnormal_blood-brain_barrier2.04172445
15MP0003724_increased_susceptibility_to1.98750734
16MP0005645_abnormal_hypothalamus_physiol1.94901434
17MP0003890_abnormal_embryonic-extraembry1.93345730
18MP0006292_abnormal_olfactory_placode1.92016534
19MP0001661_extended_life_span1.90853114
20MP0008058_abnormal_DNA_repair1.90343860
21MP0005360_urolithiasis1.85549302
22MP0000566_synostosis1.85535515
23MP0001293_anophthalmia1.78707190
24MP0006072_abnormal_retinal_apoptosis1.75802464
25MP0000372_irregular_coat_pigmentation1.65445144
26MP0000631_abnormal_neuroendocrine_gland1.59095034
27MP0003646_muscle_fatigue1.58355506
28MP0004742_abnormal_vestibular_system1.57672246
29MP0010094_abnormal_chromosome_stability1.46189123
30MP0000013_abnormal_adipose_tissue1.41720504
31MP0004043_abnormal_pH_regulation1.37812739
32MP0004019_abnormal_vitamin_homeostasis1.36318467
33MP0005253_abnormal_eye_physiology1.36258981
34MP0003806_abnormal_nucleotide_metabolis1.34725136
35MP0008775_abnormal_heart_ventricle1.33011620
36MP0005084_abnormal_gallbladder_morpholo1.32784025
37MP0004133_heterotaxia1.32529872
38MP0006035_abnormal_mitochondrial_morpho1.29444636
39MP0008872_abnormal_physiological_respon1.29345203
40MP0002095_abnormal_skin_pigmentation1.28943674
41MP0003950_abnormal_plasma_membrane1.27734305
42MP0003186_abnormal_redox_activity1.27420284
43MP0003195_calcinosis1.22407389
44MP0003718_maternal_effect1.21935271
45MP0002735_abnormal_chemical_nociception1.18837158
46MP0003938_abnormal_ear_development1.16268517
47MP0003283_abnormal_digestive_organ1.15371941
48MP0002138_abnormal_hepatobiliary_system1.14853052
49MP0001764_abnormal_homeostasis1.12119004
50MP0003567_abnormal_fetal_cardiomyocyte1.10712964
51MP0008961_abnormal_basal_metabolism1.09745951
52MP0001485_abnormal_pinna_reflex1.07727953
53MP0003880_abnormal_central_pattern1.07495950
54MP0005367_renal/urinary_system_phenotyp1.00020842
55MP0000516_abnormal_urinary_system1.00020842
56MP0003183_abnormal_peptide_metabolism0.97079694
57MP0001346_abnormal_lacrimal_gland0.96609230
58MP0005332_abnormal_amino_acid0.96392172
59MP0009333_abnormal_splenocyte_physiolog0.95046323
60MP0000026_abnormal_inner_ear0.93529017
61MP0003119_abnormal_digestive_system0.91687821
62MP0010307_abnormal_tumor_latency0.88716450
63MP0000371_diluted_coat_color0.88286690
64MP0002928_abnormal_bile_duct0.88110652
65MP0001919_abnormal_reproductive_system0.88083288
66MP0003878_abnormal_ear_physiology0.87930263
67MP0005377_hearing/vestibular/ear_phenot0.87930263
68MP0001486_abnormal_startle_reflex0.87343714
69MP0003111_abnormal_nucleus_morphology0.86494658
70MP0001873_stomach_inflammation0.84993445
71MP0003638_abnormal_response/metabolism_0.84987419
72MP0003937_abnormal_limbs/digits/tail_de0.83826977
73MP0005391_vision/eye_phenotype0.80572150
74MP0009764_decreased_sensitivity_to0.79386200
75MP0006036_abnormal_mitochondrial_physio0.77101794
76MP0001440_abnormal_grooming_behavior0.76607124
77MP0004142_abnormal_muscle_tone0.74461259
78MP0002638_abnormal_pupillary_reflex0.73492081
79MP0005195_abnormal_posterior_eye0.71841532
80MP0002876_abnormal_thyroid_physiology0.70767979
81MP0010030_abnormal_orbit_morphology0.68793052
82MP0005647_abnormal_sex_gland0.67702502
83MP0001502_abnormal_circadian_rhythm0.66732578
84MP0002733_abnormal_thermal_nociception0.65758589
85MP0009745_abnormal_behavioral_response0.65420517
86MP0003077_abnormal_cell_cycle0.65245605
87MP0003252_abnormal_bile_duct0.64379916
88MP0002697_abnormal_eye_size0.64320523
89MP0003633_abnormal_nervous_system0.63906275
90MP0003698_abnormal_male_reproductive0.63660245
91MP0000653_abnormal_sex_gland0.63097151
92MP0001929_abnormal_gametogenesis0.62552451
93MP0001286_abnormal_eye_development0.62073613
94MP0002837_dystrophic_cardiac_calcinosis0.61979560
95MP0002210_abnormal_sex_determination0.61476692
96MP0000647_abnormal_sebaceous_gland0.61370139
97MP0008873_increased_physiological_sensi0.61319532
98MP0006276_abnormal_autonomic_nervous0.61302294
99MP0002282_abnormal_trachea_morphology0.61231560
100MP0005671_abnormal_response_to0.61105879

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)6.06830637
2Hyperalaninemia (HP:0003348)6.06830637
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.06830637
4Birth length less than 3rd percentile (HP:0003561)4.35826484
53-Methylglutaconic aciduria (HP:0003535)4.15105195
6Congenital sensorineural hearing impairment (HP:0008527)3.78887096
7Conjugated hyperbilirubinemia (HP:0002908)3.75621998
8Constricted visual fields (HP:0001133)3.69884544
9Duplicated collecting system (HP:0000081)3.51136268
10Attenuation of retinal blood vessels (HP:0007843)3.47824291
11Abnormality of the renal collecting system (HP:0004742)3.27169255
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.22089168
13Abnormality of the labia minora (HP:0012880)2.89827325
14Congenital stationary night blindness (HP:0007642)2.87226586
15Supernumerary spleens (HP:0009799)2.82560541
16Acute encephalopathy (HP:0006846)2.77859053
17Concave nail (HP:0001598)2.76151640
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74778545
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73690836
20Pigmentary retinal degeneration (HP:0001146)2.66965890
21Poor speech (HP:0002465)2.62548826
22Acute necrotizing encephalopathy (HP:0006965)2.61467941
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.59084212
24Generalized aminoaciduria (HP:0002909)2.56589663
25Abnormality of serum amino acid levels (HP:0003112)2.54499240
26Homocystinuria (HP:0002156)2.50635268
27Abnormality of homocysteine metabolism (HP:0010919)2.50635268
28Spontaneous hematomas (HP:0007420)2.46687687
29Abnormality of the pons (HP:0007361)2.44920299
30Mitochondrial inheritance (HP:0001427)2.42084514
31Large for gestational age (HP:0001520)2.36128495
32Molar tooth sign on MRI (HP:0002419)2.35351077
33Abnormality of midbrain morphology (HP:0002418)2.35351077
34Oligodactyly (hands) (HP:0001180)2.34226481
35Abnormality of chromosome stability (HP:0003220)2.33714594
36Abnormality of the ileum (HP:0001549)2.32534922
37Increased CSF lactate (HP:0002490)2.32317975
38Increased serum lactate (HP:0002151)2.30885354
39Meckel diverticulum (HP:0002245)2.29881747
40Abnormality of the renal cortex (HP:0011035)2.29291046
41Abnormality of DNA repair (HP:0003254)2.28883194
42Conjunctival telangiectasia (HP:0000524)2.25988407
43Pendular nystagmus (HP:0012043)2.25711306
44Nephrogenic diabetes insipidus (HP:0009806)2.25170204
45Abnormality of the carotid arteries (HP:0005344)2.25105284
46Abnormality of the preputium (HP:0100587)2.23857552
47Arteriovenous malformation (HP:0100026)2.23768629
48Esophageal varix (HP:0002040)2.21216671
49Progressive macrocephaly (HP:0004481)2.20701190
50Decreased subcutaneous fat (HP:0001002)2.19925152
51Duodenal stenosis (HP:0100867)2.17900332
52Small intestinal stenosis (HP:0012848)2.17900332
53Chronic hepatic failure (HP:0100626)2.16423070
54Chromsome breakage (HP:0040012)2.15965677
55Optic disc pallor (HP:0000543)2.15651664
56Fatigue (HP:0012378)2.14110847
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13073937
58Thyroid-stimulating hormone excess (HP:0002925)2.13006438
59Hepatic necrosis (HP:0002605)2.12478092
60Clubbing of toes (HP:0100760)2.12347611
61Pancreatic fibrosis (HP:0100732)2.10850482
62Abnormal mitochondria in muscle tissue (HP:0008316)2.09463236
63Hyperglycinemia (HP:0002154)2.08733716
64Nephronophthisis (HP:0000090)2.07967969
65Cortical visual impairment (HP:0100704)2.05059212
66Abnormality of the renal medulla (HP:0100957)2.04925344
67Premature ovarian failure (HP:0008209)2.04435558
68Hepatocellular necrosis (HP:0001404)2.02484225
69Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98355994
70Maternal diabetes (HP:0009800)1.97739823
71White forelock (HP:0002211)1.95838604
72Increased hepatocellular lipid droplets (HP:0006565)1.94730321
73Hyperphosphaturia (HP:0003109)1.92070475
74True hermaphroditism (HP:0010459)1.89905236
75Lactic acidosis (HP:0003128)1.86857335
76Increased serum pyruvate (HP:0003542)1.86102493
77Metabolic acidosis (HP:0001942)1.86064612
78Nausea (HP:0002018)1.85571748
79Absent septum pellucidum (HP:0001331)1.85553320
80Hypoplastic iliac wings (HP:0002866)1.85223639
81Lipid accumulation in hepatocytes (HP:0006561)1.85126504
82Lethargy (HP:0001254)1.85120237
83Type I transferrin isoform profile (HP:0003642)1.85057179
84Cerebral edema (HP:0002181)1.84884174
85Progressive cerebellar ataxia (HP:0002073)1.83828027
86Renal cortical cysts (HP:0000803)1.83244177
87Methylmalonic acidemia (HP:0002912)1.83048322
88Abnormality of the fetal cardiovascular system (HP:0010948)1.81916006
89Abnormal umbilical cord blood vessels (HP:0011403)1.81916006
90Single umbilical artery (HP:0001195)1.81916006
91Congenital, generalized hypertrichosis (HP:0004540)1.81368925
92Abnormality of the fovea (HP:0000493)1.80148556
93Oligodactyly (HP:0012165)1.79664582
94Abnormality of urine glucose concentration (HP:0011016)1.79442622
95Glycosuria (HP:0003076)1.79442622
96Sensory axonal neuropathy (HP:0003390)1.78854746
97Abnormal lung lobation (HP:0002101)1.78679115
98Clitoromegaly (HP:0000057)1.78418204
99IgG deficiency (HP:0004315)1.78044384
100Abnormality of the duodenum (HP:0002246)1.77938941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.03646320
2TIE14.71150870
3ZAK3.51157194
4VRK22.93856724
5ACVR1B2.91583155
6NUAK12.80093300
7BUB12.58773163
8BMPR1B2.29841744
9MST42.21277696
10PLK42.09040269
11VRK11.89233783
12GRK11.89192082
13WNK41.84807437
14ADRBK21.73216968
15DYRK31.64129537
16CCNB11.51426246
17TTK1.51224248
18TXK1.47432325
19FRK1.45790028
20BCKDK1.44138179
21NEK11.40979931
22SRPK11.40098367
23TNIK1.39784184
24TAF11.37546858
25EIF2AK31.37047717
26MKNK21.34142455
27SGK21.30537813
28LATS11.26794893
29PLK31.24883798
30TLK11.22289239
31SGK4941.16674635
32SGK2231.16674635
33TESK21.16043130
34MAP3K31.13262660
35CDC71.11265058
36JAK31.07448237
37WNK31.07245044
38MKNK11.03925240
39TEC1.03436979
40PINK10.97853215
41STK390.94574940
42STK40.94439311
43TSSK60.90833957
44DYRK20.90057327
45EIF2AK10.89417246
46ERBB20.89158851
47NEK90.88484850
48TGFBR10.85943334
49RPS6KB20.81731530
50SGK30.81360924
51OXSR10.80287727
52ADRBK10.75959923
53STK100.75033223
54MAP3K100.74497527
55AKT30.72798921
56NME10.72312813
57PDK20.72258444
58ATR0.71817751
59WEE10.71661216
60PLK10.70785975
61CSNK1G10.69132469
62FGFR10.67572284
63AURKB0.66935825
64CDK90.65578026
65FGR0.64075366
66KDR0.62291753
67MATK0.61243470
68FLT30.57370732
69PAK30.53048562
70CDK80.52815371
71CSNK1A10.48710812
72WNK10.46626398
73EPHB20.45207321
74PRKCQ0.44247810
75MAP4K20.42951626
76PIM10.42162395
77OBSCN0.39453327
78CHEK20.38700256
79CSNK1A1L0.38034690
80SIK20.37243366
81PBK0.36522188
82CSNK2A10.35098388
83ATM0.34950822
84CSNK1G30.34000316
85NTRK20.33819110
86NEK60.31702058
87KIT0.31289725
88MAP4K10.30866978
89MAP2K30.30769633
90PRKCE0.30453302
91TRIM280.29841907
92EIF2AK20.29645136
93RPS6KB10.28856862
94MAPK130.28695637
95AURKA0.27993858
96PHKG20.27497187
97PHKG10.27497187
98CAMK10.27287521
99CSNK2A20.26776539
100CSNK1E0.26278404

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.74787228
2Proteasome_Homo sapiens_hsa030503.68349273
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.17766958
4Oxidative phosphorylation_Homo sapiens_hsa001903.09060676
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.08942694
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.59338670
7Basal transcription factors_Homo sapiens_hsa030222.40234547
8Protein export_Homo sapiens_hsa030602.33598703
9Parkinsons disease_Homo sapiens_hsa050122.25032033
10Homologous recombination_Homo sapiens_hsa034402.19681225
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17054739
12Fanconi anemia pathway_Homo sapiens_hsa034602.15372309
13Butanoate metabolism_Homo sapiens_hsa006501.89867670
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.87720323
15Collecting duct acid secretion_Homo sapiens_hsa049661.85356457
16Sulfur metabolism_Homo sapiens_hsa009201.83365197
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70426108
18RNA polymerase_Homo sapiens_hsa030201.64122739
19Mismatch repair_Homo sapiens_hsa034301.56685341
20Sulfur relay system_Homo sapiens_hsa041221.56443938
21Huntingtons disease_Homo sapiens_hsa050161.54600843
22Alzheimers disease_Homo sapiens_hsa050101.46694759
23Propanoate metabolism_Homo sapiens_hsa006401.44469929
24Nicotine addiction_Homo sapiens_hsa050331.43673191
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43367440
26Arginine biosynthesis_Homo sapiens_hsa002201.42732133
27Spliceosome_Homo sapiens_hsa030401.42603789
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42167477
29Selenocompound metabolism_Homo sapiens_hsa004501.41857057
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39962396
31Caffeine metabolism_Homo sapiens_hsa002321.36506443
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32289581
33Ribosome_Homo sapiens_hsa030101.25806563
34Nitrogen metabolism_Homo sapiens_hsa009101.25371630
35DNA replication_Homo sapiens_hsa030301.16712530
36Nucleotide excision repair_Homo sapiens_hsa034201.15385967
37Retinol metabolism_Homo sapiens_hsa008301.15321549
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14114302
39RNA degradation_Homo sapiens_hsa030181.10727320
40Peroxisome_Homo sapiens_hsa041461.09968633
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05960995
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04568546
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.02404977
44RNA transport_Homo sapiens_hsa030131.02385879
45Morphine addiction_Homo sapiens_hsa050321.00380579
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.96980540
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95843513
48Chemical carcinogenesis_Homo sapiens_hsa052040.87846849
49ABC transporters_Homo sapiens_hsa020100.87017498
50Linoleic acid metabolism_Homo sapiens_hsa005910.86854010
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82407767
52GABAergic synapse_Homo sapiens_hsa047270.82350854
53Regulation of autophagy_Homo sapiens_hsa041400.81388350
54Olfactory transduction_Homo sapiens_hsa047400.80046563
55Purine metabolism_Homo sapiens_hsa002300.79255183
56Tryptophan metabolism_Homo sapiens_hsa003800.79215513
57Cardiac muscle contraction_Homo sapiens_hsa042600.78702439
58Systemic lupus erythematosus_Homo sapiens_hsa053220.77717833
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75977346
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75539278
61Taste transduction_Homo sapiens_hsa047420.75512421
62Pyruvate metabolism_Homo sapiens_hsa006200.75056101
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74451926
64Rheumatoid arthritis_Homo sapiens_hsa053230.73958086
65Folate biosynthesis_Homo sapiens_hsa007900.73765056
66Phototransduction_Homo sapiens_hsa047440.73659700
67Vitamin digestion and absorption_Homo sapiens_hsa049770.72239671
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.71971590
69Steroid biosynthesis_Homo sapiens_hsa001000.71067712
70Metabolic pathways_Homo sapiens_hsa011000.71012148
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.67040813
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66306234
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65160155
74Pyrimidine metabolism_Homo sapiens_hsa002400.64998525
75Ether lipid metabolism_Homo sapiens_hsa005650.64739488
76Base excision repair_Homo sapiens_hsa034100.64730201
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60375241
78mRNA surveillance pathway_Homo sapiens_hsa030150.58399328
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55559345
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54600740
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52136013
82Cell cycle_Homo sapiens_hsa041100.50048853
83Alcoholism_Homo sapiens_hsa050340.48994537
84Serotonergic synapse_Homo sapiens_hsa047260.47528713
85Non-homologous end-joining_Homo sapiens_hsa034500.44676101
86Fat digestion and absorption_Homo sapiens_hsa049750.41734767
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41416744
88Circadian entrainment_Homo sapiens_hsa047130.39423470
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38494551
90beta-Alanine metabolism_Homo sapiens_hsa004100.36127567
91Glutamatergic synapse_Homo sapiens_hsa047240.35316029
92Phenylalanine metabolism_Homo sapiens_hsa003600.31613833
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31547769
94Glutathione metabolism_Homo sapiens_hsa004800.30136120
95Histidine metabolism_Homo sapiens_hsa003400.29587169
96Glycerolipid metabolism_Homo sapiens_hsa005610.28712835
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26675226
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26434488
99Malaria_Homo sapiens_hsa051440.26343704
100Vibrio cholerae infection_Homo sapiens_hsa051100.24751167

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