SF3B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.07599136
2protein localization to kinetochore (GO:0034501)4.58318986
3ribosomal small subunit biogenesis (GO:0042274)4.34386290
4nuclear pore organization (GO:0006999)4.20409797
5heterochromatin organization (GO:0070828)4.18446503
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.09438805
7nuclear pore complex assembly (GO:0051292)4.08071966
8regulation of translational fidelity (GO:0006450)3.97335692
9histone H2B ubiquitination (GO:0033523)3.95994260
10DNA strand elongation involved in DNA replication (GO:0006271)3.95730296
11sister chromatid segregation (GO:0000819)3.94408713
12DNA duplex unwinding (GO:0032508)3.93159887
13DNA geometric change (GO:0032392)3.89599306
14mitotic nuclear envelope disassembly (GO:0007077)3.87677490
15peptidyl-lysine dimethylation (GO:0018027)3.81644857
16mitotic sister chromatid segregation (GO:0000070)3.81529856
17mitotic chromosome condensation (GO:0007076)3.75737860
18pre-miRNA processing (GO:0031054)3.73810021
19ribosomal small subunit assembly (GO:0000028)3.73595459
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71221120
21DNA replication-dependent nucleosome organization (GO:0034723)3.69698889
22DNA replication-dependent nucleosome assembly (GO:0006335)3.69698889
23DNA strand elongation (GO:0022616)3.68796040
24membrane disassembly (GO:0030397)3.68014898
25nuclear envelope disassembly (GO:0051081)3.68014898
26protein localization to chromosome, centromeric region (GO:0071459)3.66231460
27regulation of nucleobase-containing compound transport (GO:0032239)3.65053513
28negative regulation of RNA splicing (GO:0033119)3.64623649
29dosage compensation (GO:0007549)3.64529470
30spliceosomal tri-snRNP complex assembly (GO:0000244)3.61906391
31peptidyl-arginine omega-N-methylation (GO:0035247)3.59253900
32IMP biosynthetic process (GO:0006188)3.57671666
33DNA replication initiation (GO:0006270)3.54945859
34negative regulation of histone methylation (GO:0031061)3.50506619
35retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.49716265
36proline biosynthetic process (GO:0006561)3.49075197
37formation of translation preinitiation complex (GO:0001731)3.48710348
38regulation of sister chromatid cohesion (GO:0007063)3.45192460
39folic acid-containing compound biosynthetic process (GO:0009396)3.45099060
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43713549
41negative regulation of mRNA processing (GO:0050686)3.39050092
42chromatin assembly (GO:0031497)3.38906017
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36389666
44mitotic sister chromatid cohesion (GO:0007064)3.34579945
45regulation of translational termination (GO:0006449)3.33588346
46protein export from nucleus (GO:0006611)3.32241138
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31499716
48translesion synthesis (GO:0019985)3.29832722
49regulation of histone H3-K27 methylation (GO:0061085)3.26783358
50regulation of histone H3-K9 methylation (GO:0051570)3.26565709
51protein retention in ER lumen (GO:0006621)3.23892329
52regulation of spindle organization (GO:0090224)3.21855866
53negative regulation of mRNA metabolic process (GO:1903312)3.19905094
54peptidyl-arginine methylation (GO:0018216)3.17546769
55peptidyl-arginine N-methylation (GO:0035246)3.17546769
56telomere maintenance via semi-conservative replication (GO:0032201)3.16433037
57glucocorticoid receptor signaling pathway (GO:0042921)3.16034236
58protein-DNA complex disassembly (GO:0032986)3.14030353
59nucleosome disassembly (GO:0006337)3.14030353
60alternative mRNA splicing, via spliceosome (GO:0000380)3.12967575
61regulation of NFAT protein import into nucleus (GO:0051532)3.09334593
62DNA conformation change (GO:0071103)3.09157686
63histone H2A monoubiquitination (GO:0035518)3.08591677
64* mRNA splicing, via spliceosome (GO:0000398)3.05770784
65* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.05770784
66mitotic metaphase plate congression (GO:0007080)3.04775125
67protein localization to microtubule (GO:0035372)3.03777240
68positive regulation of chromosome segregation (GO:0051984)3.03407738
69positive regulation of RNA splicing (GO:0033120)3.03206613
70pore complex assembly (GO:0046931)3.03161247
71regulation of DNA damage checkpoint (GO:2000001)3.03061892
72* RNA splicing, via transesterification reactions (GO:0000375)3.02311467
73postreplication repair (GO:0006301)3.01050771
74viral transcription (GO:0019083)3.00674003
75positive regulation of DNA-templated transcription, elongation (GO:0032786)3.00006513
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99490906
77nuclear envelope organization (GO:0006998)2.98722815
78modulation by virus of host process (GO:0019054)2.97618660
79protein localization to chromosome (GO:0034502)2.96484441
80IMP metabolic process (GO:0046040)2.96316212
81RNA stabilization (GO:0043489)2.96157134
82mRNA stabilization (GO:0048255)2.96157134
83mitotic recombination (GO:0006312)2.96148300
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93928584
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.93928584
86regulation of chromosome segregation (GO:0051983)2.93578657
87ncRNA 3-end processing (GO:0043628)2.93462831
88regulation of RNA export from nucleus (GO:0046831)2.93110825
89establishment of integrated proviral latency (GO:0075713)2.91891474
90intracellular estrogen receptor signaling pathway (GO:0030520)2.91869081
91protein complex localization (GO:0031503)2.91447128
92ribonucleoprotein complex biogenesis (GO:0022613)2.90337210
93chromatin assembly or disassembly (GO:0006333)2.88875175
943-UTR-mediated mRNA stabilization (GO:0070935)2.88643896
95positive regulation of nuclease activity (GO:0032075)2.88398788
96DNA topological change (GO:0006265)2.87705016
97DNA replication checkpoint (GO:0000076)2.87462412
98histone arginine methylation (GO:0034969)2.87190872
99regulation of posttranscriptional gene silencing (GO:0060147)2.86812853
100regulation of gene silencing by miRNA (GO:0060964)2.86812853
101regulation of gene silencing by RNA (GO:0060966)2.86812853
102regulation of mitotic spindle organization (GO:0060236)2.86000398
103activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.85189226
104nucleobase biosynthetic process (GO:0046112)2.84755916
105chromosome condensation (GO:0030261)2.84579376
106modulation by symbiont of host cellular process (GO:0044068)2.84009608
107pentose-phosphate shunt (GO:0006098)2.83122764
108embryonic process involved in female pregnancy (GO:0060136)2.82548862
109negative regulation of chromosome segregation (GO:0051985)2.80052005
110Golgi transport vesicle coating (GO:0048200)2.79920695
111COPI coating of Golgi vesicle (GO:0048205)2.79920695
112mitotic spindle assembly checkpoint (GO:0007094)2.79313224
113protein maturation by protein folding (GO:0022417)2.78094132
114telomere maintenance via recombination (GO:0000722)2.78036518
115viral mRNA export from host cell nucleus (GO:0046784)2.77333264
116spindle assembly checkpoint (GO:0071173)2.76907956
117transcription from RNA polymerase I promoter (GO:0006360)2.75330412
118translational termination (GO:0006415)2.75308503
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.73904086
120apoptotic process involved in morphogenesis (GO:0060561)2.73644408
121histone H2A acetylation (GO:0043968)2.73393706
122activation of Rac GTPase activity (GO:0032863)2.73197477
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.72959058
124negative regulation of sister chromatid segregation (GO:0033046)2.72959058
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.72959058
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.72959058
127maturation of SSU-rRNA (GO:0030490)2.72026057
128mRNA transport (GO:0051028)2.71960585
129metaphase plate congression (GO:0051310)2.70268340
130ribosome biogenesis (GO:0042254)2.70125143
131ATP-dependent chromatin remodeling (GO:0043044)2.70068801
132DNA packaging (GO:0006323)2.65141516
133paraxial mesoderm development (GO:0048339)2.64405620
134telomere maintenance via telomere lengthening (GO:0010833)2.64356804
135mitotic spindle checkpoint (GO:0071174)2.64097920
136regulation of nuclease activity (GO:0032069)2.63961881
137positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63944615
138regulation of chromatin binding (GO:0035561)2.63346515
139endoplasmic reticulum unfolded protein response (GO:0030968)2.63251682
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60927372
141cellular protein complex localization (GO:0034629)2.59551667
142modulation by virus of host morphology or physiology (GO:0019048)2.59412492
143mitotic G1 DNA damage checkpoint (GO:0031571)2.58726409
144ER-nucleus signaling pathway (GO:0006984)2.56652776
145mRNA polyadenylation (GO:0006378)2.55467035
146mitotic nuclear envelope reassembly (GO:0007084)2.55444992
147nuclear envelope reassembly (GO:0031468)2.55444992
148establishment of mitotic spindle localization (GO:0040001)2.55273117
149translational initiation (GO:0006413)2.53347737
150vesicle coating (GO:0006901)2.52521047
151rRNA transcription (GO:0009303)2.52210887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.03012524
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.16632995
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.49124844
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45635756
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39485515
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.24756889
7MYC_22102868_ChIP-Seq_BL_Human3.11254481
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90277164
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66924510
10XRN2_22483619_ChIP-Seq_HELA_Human2.24820515
11CIITA_25753668_ChIP-Seq_RAJI_Human2.21523051
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17808268
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16642207
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.13143288
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06544097
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.01401107
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99788253
18AR_21909140_ChIP-Seq_LNCAP_Human1.96934321
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96239515
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95114876
21VDR_21846776_ChIP-Seq_THP-1_Human1.91730809
22* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84403393
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82256599
24* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77887285
25LXR_22292898_ChIP-Seq_THP-1_Human1.77589798
26RACK7_27058665_Chip-Seq_MCF-7_Human1.75731016
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72463388
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.68227945
29* ETS1_20019798_ChIP-Seq_JURKAT_Human1.68176645
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61347003
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60907329
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60446451
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59728039
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53201554
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52258400
36KDM5A_27292631_Chip-Seq_BREAST_Human1.51977692
37* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50702851
38* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48856876
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47103065
40TTF2_22483619_ChIP-Seq_HELA_Human1.46861458
41* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46366986
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.45997091
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44139870
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43731482
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41757733
46GABP_19822575_ChIP-Seq_HepG2_Human1.40729319
47* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39675118
48FOXP3_21729870_ChIP-Seq_TREG_Human1.37598750
49TCF7_22412390_ChIP-Seq_EML_Mouse1.36964337
50KDM2B_26808549_Chip-Seq_DND41_Human1.36860986
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35413522
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34775697
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31471349
54* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31363728
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30992511
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30584848
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30000034
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29519480
59* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27123915
60VDR_23849224_ChIP-Seq_CD4+_Human1.26816546
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25799502
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25742762
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25721591
64TFEB_21752829_ChIP-Seq_HELA_Human1.24521552
65DCP1A_22483619_ChIP-Seq_HELA_Human1.23693819
66ZNF263_19887448_ChIP-Seq_K562_Human1.23365795
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23242146
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23129456
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.21271101
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21098448
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.19730080
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19521120
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19209494
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18768566
75UTX_26944678_Chip-Seq_JUKART_Human1.18649276
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18508501
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18403152
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17354275
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.16673021
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.16456371
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15704800
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15451682
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14356191
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14085044
85P68_20966046_ChIP-Seq_HELA_Human1.11234170
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10290573
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10091305
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09620305
89* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07903085
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06715788
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06491363
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.06387185
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05333903
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05023825
95CHD1_26751641_Chip-Seq_LNCaP_Human1.04960258
96MAF_26560356_Chip-Seq_TH2_Human1.04729468
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04722394
98TP53_22127205_ChIP-Seq_IMR90_Human1.04330154
99* MAF_26560356_Chip-Seq_TH1_Human1.04078107
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03926599
101* GABP_17652178_ChIP-ChIP_JURKAT_Human1.01926955
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01141293
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00995969
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00113015
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99693763
106KDM2B_26808549_Chip-Seq_K562_Human0.98898062
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98707626
108SMC4_20622854_ChIP-Seq_HELA_Human0.98154714
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98065294
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97096232
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95532904
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95402718
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95236751
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94324335
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93968871
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93617422
117CLOCK_20551151_ChIP-Seq_293T_Human0.93312015
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90305135
119* ATF3_27146783_Chip-Seq_COLON_Human0.88338883
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87728729
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87539501
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86711088
123NCOR1_26117541_ChIP-Seq_K562_Human0.84961402
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84013480
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83614217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.53834297
2MP0003111_abnormal_nucleus_morphology3.49977340
3MP0004957_abnormal_blastocyst_morpholog3.35066485
4MP0003693_abnormal_embryo_hatching3.34375264
5MP0003077_abnormal_cell_cycle3.24051750
6MP0010352_gastrointestinal_tract_polyps2.85770327
7MP0003123_paternal_imprinting2.80706278
8MP0001730_embryonic_growth_arrest2.58299526
9MP0005076_abnormal_cell_differentiation2.57438523
10MP0003705_abnormal_hypodermis_morpholog2.53613101
11MP0000537_abnormal_urethra_morphology2.45485561
12MP0008260_abnormal_autophagy2.41786849
13MP0008007_abnormal_cellular_replicative2.38721814
14MP0004185_abnormal_adipocyte_glucose2.36231851
15MP0008057_abnormal_DNA_replication2.30692661
16MP0000350_abnormal_cell_proliferation2.29331551
17MP0010030_abnormal_orbit_morphology2.28229138
18MP0002653_abnormal_ependyma_morphology2.12461172
19MP0003121_genomic_imprinting2.09736161
20MP0005451_abnormal_body_composition2.04902412
21MP0008877_abnormal_DNA_methylation2.04223373
22MP0010307_abnormal_tumor_latency1.96383170
23MP0001348_abnormal_lacrimal_gland1.95651815
24MP0008058_abnormal_DNA_repair1.92960474
25MP0004197_abnormal_fetal_growth/weight/1.90873906
26MP0002084_abnormal_developmental_patter1.89883244
27MP0001697_abnormal_embryo_size1.89311236
28MP0008932_abnormal_embryonic_tissue1.87009178
29MP0004808_abnormal_hematopoietic_stem1.84731395
30MP0002085_abnormal_embryonic_tissue1.83410595
31MP0001672_abnormal_embryogenesis/_devel1.83158190
32MP0005380_embryogenesis_phenotype1.83158190
33MP0004858_abnormal_nervous_system1.78840197
34MP0002080_prenatal_lethality1.74463361
35MP0003984_embryonic_growth_retardation1.73225597
36MP0002088_abnormal_embryonic_growth/wei1.70641973
37MP0003283_abnormal_digestive_organ1.66917237
38MP0009278_abnormal_bone_marrow1.65958782
39MP0002396_abnormal_hematopoietic_system1.61345673
40MP0004264_abnormal_extraembryonic_tissu1.59554195
41MP0006054_spinal_hemorrhage1.56069810
42MP0005623_abnormal_meninges_morphology1.54945987
43MP0002086_abnormal_extraembryonic_tissu1.53353811
44MP0003122_maternal_imprinting1.49953213
45MP0001849_ear_inflammation1.48870800
46MP0004233_abnormal_muscle_weight1.48390111
47MP0000678_abnormal_parathyroid_gland1.48257129
48MP0000428_abnormal_craniofacial_morphol1.47204350
49MP0001346_abnormal_lacrimal_gland1.46559283
50MP0003119_abnormal_digestive_system1.44134802
51MP0009053_abnormal_anal_canal1.41913579
52MP0005501_abnormal_skin_physiology1.41207942
53MP0003566_abnormal_cell_adhesion1.39919437
54MP0001727_abnormal_embryo_implantation1.39201326
55MP0003115_abnormal_respiratory_system1.38992121
56MP0002796_impaired_skin_barrier1.38951712
57MP0000569_abnormal_digit_pigmentation1.38833621
58MP0004947_skin_inflammation1.33891953
59MP0003567_abnormal_fetal_cardiomyocyte1.33101719
60MP0009672_abnormal_birth_weight1.32519933
61MP0002877_abnormal_melanocyte_morpholog1.31882789
62MP0003315_abnormal_perineum_morphology1.29069916
63MP0003890_abnormal_embryonic-extraembry1.27665323
64MP0002060_abnormal_skin_morphology1.26226922
65MP0008961_abnormal_basal_metabolism1.25107756
66MP0000313_abnormal_cell_death1.23819851
67MP0001293_anophthalmia1.23261273
68MP0005257_abnormal_intraocular_pressure1.21946693
69MP0000703_abnormal_thymus_morphology1.20587035
70MP0003787_abnormal_imprinting1.18982247
71MP0003453_abnormal_keratinocyte_physiol1.17766741
72MP0000733_abnormal_muscle_development1.17320255
73MP0009703_decreased_birth_body1.16682006
74MP0002019_abnormal_tumor_incidence1.16574466
75MP0005058_abnormal_lysosome_morphology1.15197552
76MP0005666_abnormal_adipose_tissue1.14976062
77MP0010234_abnormal_vibrissa_follicle1.13855499
78MP0002009_preneoplasia1.10102764
79MP0003942_abnormal_urinary_system1.09057580
80MP0001915_intracranial_hemorrhage1.08559719
81MP0000377_abnormal_hair_follicle1.08557416
82MP0008438_abnormal_cutaneous_collagen1.07406194
83MP0000566_synostosis1.07086144
84MP0000534_abnormal_ureter_morphology1.06292533
85MP0009333_abnormal_splenocyte_physiolog1.05451618
86MP0003861_abnormal_nervous_system1.04761783
87MP0001873_stomach_inflammation1.02825678
88MP0001216_abnormal_epidermal_layer1.02749493
89MP0005023_abnormal_wound_healing1.00608591
90MP0002234_abnormal_pharynx_morphology1.00299518
91MP0003300_gastrointestinal_ulcer0.99611335
92MP0003763_abnormal_thymus_physiology0.98791510
93MP0002111_abnormal_tail_morphology0.98762981
94MP0002089_abnormal_postnatal_growth/wei0.96244471
95MP0002697_abnormal_eye_size0.96236494
96MP0000490_abnormal_crypts_of0.93752463
97MP0003935_abnormal_craniofacial_develop0.92705093
98MP0002925_abnormal_cardiovascular_devel0.92415956
99MP0003091_abnormal_cell_migration0.91620789
100MP0005375_adipose_tissue_phenotype0.91315139
101MP0002092_abnormal_eye_morphology0.91171207
102MP0009931_abnormal_skin_appearance0.90150210
103MP0001851_eye_inflammation0.87279975
104MP0005384_cellular_phenotype0.86010671
105MP0005621_abnormal_cell_physiology0.85788275
106MP0003943_abnormal_hepatobiliary_system0.85014296
107MP0005197_abnormal_uvea_morphology0.83832923
108MP0003385_abnormal_body_wall0.83677142
109MP0009379_abnormal_foot_pigmentation0.82752669
110MP0003786_premature_aging0.82696898
111MP0003329_amyloid_beta_deposits0.82186366
112MP0000627_abnormal_mammary_gland0.81079269
113MP0002249_abnormal_larynx_morphology0.80091394
114MP0000358_abnormal_cell_content/0.79533478
115MP0008789_abnormal_olfactory_epithelium0.78006800
116MP0002398_abnormal_bone_marrow0.77920321
117MP0003937_abnormal_limbs/digits/tail_de0.77894813
118MP0000477_abnormal_intestine_morphology0.77451504
119MP0005397_hematopoietic_system_phenotyp0.77093785
120MP0001545_abnormal_hematopoietic_system0.77093785
121MP0001853_heart_inflammation0.75938989
122MP0003221_abnormal_cardiomyocyte_apopto0.75442697
123MP0002166_altered_tumor_susceptibility0.75166000
124MP0001881_abnormal_mammary_gland0.75159087
125MP0008770_decreased_survivor_rate0.74903450
126MP0004133_heterotaxia0.74810065
127MP0000858_altered_metastatic_potential0.73616281
128MP0010630_abnormal_cardiac_muscle0.73430842
129MP0000003_abnormal_adipose_tissue0.72421798
130MP0000462_abnormal_digestive_system0.72326782
131MP0000266_abnormal_heart_morphology0.71500142
132MP0005409_darkened_coat_color0.71141903
133MP0005408_hypopigmentation0.70707098
134MP0002081_perinatal_lethality0.70188012
135MP0002970_abnormal_white_adipose0.70088871
136MP0002932_abnormal_joint_morphology0.69531306
137MP0002722_abnormal_immune_system0.68352458
138MP0005394_taste/olfaction_phenotype0.66749198
139MP0005499_abnormal_olfactory_system0.66749198
140MP0001145_abnormal_male_reproductive0.66350824
141MP0001286_abnormal_eye_development0.65786038
142MP0002116_abnormal_craniofacial_bone0.65766014
143MP0003303_peritoneal_inflammation0.65154527
144MP0002210_abnormal_sex_determination0.64863595

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.72260599
2Ependymoma (HP:0002888)3.59014561
3Increased nuchal translucency (HP:0010880)3.51471905
4Selective tooth agenesis (HP:0001592)3.31664713
5Renal duplication (HP:0000075)3.23166254
6Deep philtrum (HP:0002002)3.22891601
7Achilles tendon contracture (HP:0001771)3.15337842
8Short 4th metacarpal (HP:0010044)3.14118583
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.14118583
10Colon cancer (HP:0003003)3.05196409
11Medulloblastoma (HP:0002885)2.96404989
12Volvulus (HP:0002580)2.83107985
13Astrocytoma (HP:0009592)2.75740678
14Abnormality of the astrocytes (HP:0100707)2.75740678
15Abnormality of the Achilles tendon (HP:0005109)2.74298524
16Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73991551
17Proximal placement of thumb (HP:0009623)2.73449973
18Deviation of the thumb (HP:0009603)2.69310944
19Periodontitis (HP:0000704)2.64320115
20Missing ribs (HP:0000921)2.59973250
21Progressive muscle weakness (HP:0003323)2.57261777
22Pointed chin (HP:0000307)2.55718277
23Insomnia (HP:0100785)2.54842195
24Abnormal number of incisors (HP:0011064)2.52600685
25Trismus (HP:0000211)2.50934605
26Elfin facies (HP:0004428)2.49255408
27Renovascular hypertension (HP:0100817)2.48896827
28Basal cell carcinoma (HP:0002671)2.45462586
29Sparse scalp hair (HP:0002209)2.45445035
30Overriding aorta (HP:0002623)2.41939061
31Bowel diverticulosis (HP:0005222)2.40903134
32Patellar dislocation (HP:0002999)2.37728475
33Abnormality of the 4th metacarpal (HP:0010012)2.37619135
34Shallow orbits (HP:0000586)2.37401622
35Long palpebral fissure (HP:0000637)2.35888455
36Cupped ribs (HP:0000887)2.35035514
37Ulnar bowing (HP:0003031)2.34576695
38Premature rupture of membranes (HP:0001788)2.33939564
39Metaphyseal cupping (HP:0003021)2.33839772
40Cerebral aneurysm (HP:0004944)2.32642772
41Vertebral compression fractures (HP:0002953)2.32640028
42High pitched voice (HP:0001620)2.31953407
43Abnormality of the intervertebral disk (HP:0005108)2.31926933
44Pelvic girdle muscle weakness (HP:0003749)2.29794558
45Recurrent gram-negative bacterial infections (HP:0005420)2.29476376
46Malignant gastrointestinal tract tumors (HP:0006749)2.28472218
47Gastrointestinal carcinoma (HP:0002672)2.28472218
48Abnormality of the lower motor neuron (HP:0002366)2.28056003
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.27795046
50Abnormality of the anterior horn cell (HP:0006802)2.25292006
51Degeneration of anterior horn cells (HP:0002398)2.25292006
52Abnormal gallbladder physiology (HP:0012438)2.25111683
53Cholecystitis (HP:0001082)2.25111683
54Glioma (HP:0009733)2.24177324
55Disproportionate tall stature (HP:0001519)2.21779689
56Shoulder girdle muscle weakness (HP:0003547)2.21661065
57Vertebral arch anomaly (HP:0008438)2.21361998
58Rectal prolapse (HP:0002035)2.21026704
59Short nail (HP:0001799)2.20349989
60Asymmetry of the thorax (HP:0001555)2.19056018
61Progressive external ophthalmoplegia (HP:0000590)2.16138414
62Flat acetabular roof (HP:0003180)2.15815335
63Dysmetric saccades (HP:0000641)2.15669038
64Insidious onset (HP:0003587)2.14153379
65Termporal pattern (HP:0011008)2.14153379
66Entropion (HP:0000621)2.11953218
67Nasal speech (HP:0001611)2.11943934
68Testicular atrophy (HP:0000029)2.08248626
69Hypoplastic toenails (HP:0001800)2.08176613
70Deep palmar crease (HP:0006191)2.08043070
7111 pairs of ribs (HP:0000878)2.07690989
72Back pain (HP:0003418)2.07667288
73Intestinal polyp (HP:0005266)2.07665010
74Abnormality of the calcaneus (HP:0008364)2.07006576
75Ankyloglossia (HP:0010296)2.06642044
76Abnormality of oral frenula (HP:0000190)2.06162650
77Biconcave vertebral bodies (HP:0004586)2.04880900
78Neoplasm of the pancreas (HP:0002894)2.04253959
79Truncus arteriosus (HP:0001660)2.03925740
80Angiofibromas (HP:0010615)2.03719989
81Adenoma sebaceum (HP:0009720)2.03719989
82Cutaneous melanoma (HP:0012056)2.03576150
83Atresia of the external auditory canal (HP:0000413)2.03143648
84Increased density of long bones (HP:0006392)2.02542719
85Intestinal polyposis (HP:0200008)2.00978746
86Reticulocytosis (HP:0001923)2.00499384
87Trigonocephaly (HP:0000243)1.99816422
88Patellar aplasia (HP:0006443)1.99001192
89Rhabdomyosarcoma (HP:0002859)1.97335567
90Bowel incontinence (HP:0002607)1.97090951
91Biliary tract neoplasm (HP:0100574)1.96185969
92Broad palm (HP:0001169)1.95903781
93Hyperparathyroidism (HP:0000843)1.95597046
94Cafe-au-lait spot (HP:0000957)1.93833861
95Broad face (HP:0000283)1.93816185
96Overlapping toe (HP:0001845)1.93772818
97Abnormality of reticulocytes (HP:0004312)1.93548015
98Ankle contracture (HP:0006466)1.93191187
99Spinal cord compression (HP:0002176)1.92804422
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.92256472
101Cellulitis (HP:0100658)1.91584256
102Abnormality of the distal phalanges of the toes (HP:0010182)1.90608125
103Microvesicular hepatic steatosis (HP:0001414)1.90592606
104Neoplasm of striated muscle (HP:0009728)1.90357291
105Skin tags (HP:0010609)1.90275282
106Flat cornea (HP:0007720)1.89751017
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89705486
108Abnormality of the musculature of the pelvis (HP:0001469)1.89327447
109Abnormality of the hip-girdle musculature (HP:0001445)1.89327447
110Bladder diverticulum (HP:0000015)1.88563597
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.87972106
112Neoplasm of the oral cavity (HP:0100649)1.87862214
113Aplasia/Hypoplasia of the patella (HP:0006498)1.87649692
114Obsessive-compulsive behavior (HP:0000722)1.86960171
115Autoimmune hemolytic anemia (HP:0001890)1.86300569
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.85520026
117Arnold-Chiari malformation (HP:0002308)1.84540926
118Abnormal large intestine physiology (HP:0012700)1.84270364
119Heterotopia (HP:0002282)1.83484911
120Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82655755
121Prominent nose (HP:0000448)1.81997101
122Skull defect (HP:0001362)1.81839746
123Abnormality of the labia minora (HP:0012880)1.81166208
124Orthostatic hypotension (HP:0001278)1.80674724
125Hand muscle atrophy (HP:0009130)1.80321731
126Urethral obstruction (HP:0000796)1.80112623
127Ovarian neoplasm (HP:0100615)1.79270266
128Preauricular skin tag (HP:0000384)1.79166629
129Cutis marmorata (HP:0000965)1.78813833
130Septate vagina (HP:0001153)1.78450626
131Sparse lateral eyebrow (HP:0005338)1.77994850
132Abnormal ossification of hand bones (HP:0005921)1.77507917
133Segmental peripheral demyelination/remyelination (HP:0003481)1.76599558
134Protrusio acetabuli (HP:0003179)1.76219384
135Progressive hearing impairment (HP:0001730)1.76181793
136Truncal obesity (HP:0001956)1.75877732
137Abnormality of the tricuspid valve (HP:0001702)1.75758890
138Increased connective tissue (HP:0009025)1.75280418
139Gingivitis (HP:0000230)1.74764148
140Abnormality of carpal bone ossification (HP:0006257)1.74028564
141Hypoparathyroidism (HP:0000829)1.73585589
142Fragile skin (HP:0001030)1.72881918
143Reticulocytopenia (HP:0001896)1.72814452
144Poikiloderma (HP:0001029)1.72751300
145Megalocornea (HP:0000485)1.72678949
146Bicuspid aortic valve (HP:0001647)1.72351596
147Broad thumb (HP:0011304)1.71714493
148Abnormality of the diencephalon (HP:0010662)1.71458567
149Hypertensive crisis (HP:0100735)1.71325949
150Fibrous tissue neoplasm (HP:0012316)1.70901216
151Persistence of primary teeth (HP:0006335)1.69847634
152Esophageal atresia (HP:0002032)1.69696730
153Hallux valgus (HP:0001822)1.69553063
154Broad distal phalanx of finger (HP:0009836)1.69462884
155Spastic diplegia (HP:0001264)1.69327591
156Squamous cell carcinoma (HP:0002860)1.68850416
157Enlarged penis (HP:0000040)1.68572591
158Deviation of the hallux (HP:0010051)1.68511472
159Subacute progressive viral hepatitis (HP:0006572)1.68111262
160Unilateral renal agenesis (HP:0000122)1.66945687
161Freckling (HP:0001480)1.66311317
162Atelectasis (HP:0100750)1.65747345
163Multiple enchondromatosis (HP:0005701)1.65539841
164Fibroma (HP:0010614)1.65320376
165Sandal gap (HP:0001852)1.65058352
166Abnormality of the fingertips (HP:0001211)1.64882483
167Chromsome breakage (HP:0040012)1.64471799
168Uterine neoplasm (HP:0010784)1.64466845
169Distal upper limb amyotrophy (HP:0007149)1.64216548
170Upper limb amyotrophy (HP:0009129)1.64216548
171Pseudobulbar signs (HP:0002200)1.63823928
172Rough bone trabeculation (HP:0100670)1.63774028
173Spina bifida occulta (HP:0003298)1.63532208
174Chronic bronchitis (HP:0004469)1.63178161
175Distal lower limb amyotrophy (HP:0008944)1.61285072
176Neoplasm of the colon (HP:0100273)1.61008592
177Amaurosis fugax (HP:0100576)1.60782216
178Long eyelashes (HP:0000527)1.59892612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.94802561
2CDC73.93969828
3EEF2K3.90616522
4TRIB33.82068965
5PKN23.44726591
6PASK3.43772638
7MAP3K103.13059678
8BUB12.69453623
9NEK22.68710063
10NEK12.64063131
11PBK2.57240965
12CDK122.33236602
13NME22.22709010
14TSSK62.18123130
15PRPF4B2.15060462
16WEE12.07471732
17FGFR41.92672584
18IRAK31.92507747
19SCYL21.92416712
20TESK21.74182845
21ALK1.73954840
22EIF2AK11.69156043
23PAK41.67498742
24RPS6KB21.59941791
25TTK1.58018437
26STK101.52279505
27LRRK21.48217828
28ATR1.43134727
29TESK11.43007654
30CDK41.42732915
31PTK61.42192029
32PRKCH1.39836440
33PRKD31.37861099
34RPS6KA41.30217253
35TTN1.29065853
36PLK11.28231800
37MAP3K81.27295486
38CHEK11.22998101
39TGFBR11.17753875
40PDGFRA1.16584249
41AURKB1.14793552
42BRSK11.13412807
43VRK21.12729862
44KSR21.10938221
45MTOR1.07489624
46EPHB11.06979563
47PLK31.02836298
48MKNK11.02513167
49CDK71.01397023
50MAP4K10.98858443
51RIPK10.98092273
52CAMK1D0.96680851
53FGFR10.93367930
54CDK20.93202089
55TLK10.91180590
56BRSK20.91180235
57BRD40.90180591
58MST1R0.89922410
59DYRK30.85968486
60NTRK10.83546244
61CDK60.83270587
62ILK0.81434558
63PAK20.81002256
64SIK20.80835132
65ATM0.80461448
66UHMK10.80038383
67PNCK0.79871212
68ICK0.77729713
69FLT30.76616840
70GRK60.75242143
71DAPK10.73151523
72CCNB10.72753938
73PTK20.72331743
74SRPK10.70415998
75AURKA0.68441680
76CDK90.67759185
77CDK10.67624105
78CAMK1G0.66752995
79CHEK20.66673539
80ARAF0.65611520
81LIMK10.65333447
82MAP3K10.65305507
83BMX0.65193208
84TAOK20.62705441
85STK40.61743551
86PAK10.58183092
87PRKD20.58145602
88TYRO30.56726613
89MARK20.56261491
90EPHA20.55390516
91MAPK110.55003134
92PRKDC0.54291698
93BRAF0.51995537
94CDK150.51061064
95CAMKK10.50418298
96CDK11A0.49432337
97AKT20.48886331
98MELK0.48813630
99RAF10.48422070
100CDK80.48238124
101MKNK20.48096481
102MAP3K90.47609335
103CDK180.47460660
104MAP3K130.46848421
105SIK10.46642359
106KSR10.46453065
107PRKCI0.45858150
108MAP2K30.45319344
109MAP2K20.44627901
110CDK140.44543039
111CLK10.43866558
112* CSNK1E0.43677831
113BTK0.43534035
114CSNK2A20.43062393
115PDPK10.42611552
116RPS6KA10.41100108
117LATS20.40556857
118RPS6KA20.40556817
119TAOK10.40512505
120MAPK140.39670195
121CSNK1D0.39363161
122HIPK20.38004487
123RPS6KL10.37659557
124RPS6KC10.37659557
125IRAK20.37171237
126ERN10.37153495
127ZAP700.36880357
128RET0.36572777
129PDGFRB0.35826862
130ERBB40.35749826
131MAP3K110.35310051
132MAPK90.34763633
133DYRK1B0.33955227
134STK30.33068324

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.06662310
2Mismatch repair_Homo sapiens_hsa034303.44658859
3* Spliceosome_Homo sapiens_hsa030403.13976400
4RNA transport_Homo sapiens_hsa030132.79063832
5Cell cycle_Homo sapiens_hsa041102.63806248
6Base excision repair_Homo sapiens_hsa034102.58722393
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43101232
8mRNA surveillance pathway_Homo sapiens_hsa030152.23333741
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15531345
10Nucleotide excision repair_Homo sapiens_hsa034202.12775109
11One carbon pool by folate_Homo sapiens_hsa006702.00999122
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87803458
13Homologous recombination_Homo sapiens_hsa034401.64683771
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61587877
15Pentose phosphate pathway_Homo sapiens_hsa000301.52603521
16Chronic myeloid leukemia_Homo sapiens_hsa052201.50980262
17Oocyte meiosis_Homo sapiens_hsa041141.47011476
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.44152837
19Non-homologous end-joining_Homo sapiens_hsa034501.40925961
20Viral carcinogenesis_Homo sapiens_hsa052031.37987084
21Colorectal cancer_Homo sapiens_hsa052101.36115643
22HTLV-I infection_Homo sapiens_hsa051661.30811869
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30805845
24Prion diseases_Homo sapiens_hsa050201.28936755
25Ribosome_Homo sapiens_hsa030101.27111653
26MicroRNAs in cancer_Homo sapiens_hsa052061.27060265
27RNA degradation_Homo sapiens_hsa030181.25901189
28Non-small cell lung cancer_Homo sapiens_hsa052231.22888266
29Notch signaling pathway_Homo sapiens_hsa043301.22394116
30Fructose and mannose metabolism_Homo sapiens_hsa000511.22179788
31Basal cell carcinoma_Homo sapiens_hsa052171.19165393
32Antigen processing and presentation_Homo sapiens_hsa046121.19152734
33p53 signaling pathway_Homo sapiens_hsa041151.18989091
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.17275040
35Carbon metabolism_Homo sapiens_hsa012001.17021792
36mTOR signaling pathway_Homo sapiens_hsa041501.16921319
37Hippo signaling pathway_Homo sapiens_hsa043901.15235064
38Fanconi anemia pathway_Homo sapiens_hsa034601.14628211
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13958450
40Thyroid cancer_Homo sapiens_hsa052161.11277492
41Epstein-Barr virus infection_Homo sapiens_hsa051691.11081828
42Small cell lung cancer_Homo sapiens_hsa052221.07319339
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06279485
44ErbB signaling pathway_Homo sapiens_hsa040121.05643704
45Endometrial cancer_Homo sapiens_hsa052131.03779626
46Bladder cancer_Homo sapiens_hsa052190.99704999
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98949338
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96376171
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93120549
50Glioma_Homo sapiens_hsa052140.91880885
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.91451226
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90895824
53Proteoglycans in cancer_Homo sapiens_hsa052050.90010190
54Systemic lupus erythematosus_Homo sapiens_hsa053220.87867209
55Pyrimidine metabolism_Homo sapiens_hsa002400.86824528
56Hedgehog signaling pathway_Homo sapiens_hsa043400.86427737
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86356622
58Proteasome_Homo sapiens_hsa030500.85506861
59Alcoholism_Homo sapiens_hsa050340.84997970
60Adherens junction_Homo sapiens_hsa045200.84113820
61Pancreatic cancer_Homo sapiens_hsa052120.81738554
62Estrogen signaling pathway_Homo sapiens_hsa049150.78615330
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78416346
64Biosynthesis of amino acids_Homo sapiens_hsa012300.78294813
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77964961
66Acute myeloid leukemia_Homo sapiens_hsa052210.77926766
67Lysine degradation_Homo sapiens_hsa003100.77913779
68Hepatitis C_Homo sapiens_hsa051600.73903529
69Viral myocarditis_Homo sapiens_hsa054160.71941209
70RNA polymerase_Homo sapiens_hsa030200.71867820
71HIF-1 signaling pathway_Homo sapiens_hsa040660.71532151
72Pathways in cancer_Homo sapiens_hsa052000.69730924
73Other glycan degradation_Homo sapiens_hsa005110.69594681
74Hepatitis B_Homo sapiens_hsa051610.68111968
75VEGF signaling pathway_Homo sapiens_hsa043700.68017397
76Choline metabolism in cancer_Homo sapiens_hsa052310.67751034
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67160634
78Measles_Homo sapiens_hsa051620.67155468
79Wnt signaling pathway_Homo sapiens_hsa043100.66388536
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66232334
81Herpes simplex infection_Homo sapiens_hsa051680.65490132
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64579644
83Prostate cancer_Homo sapiens_hsa052150.64271654
84Apoptosis_Homo sapiens_hsa042100.63932878
85Focal adhesion_Homo sapiens_hsa045100.62890406
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62310736
87Renal cell carcinoma_Homo sapiens_hsa052110.61990421
88Basal transcription factors_Homo sapiens_hsa030220.61865158
89B cell receptor signaling pathway_Homo sapiens_hsa046620.61650077
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60246360
91Gap junction_Homo sapiens_hsa045400.60226492
92Galactose metabolism_Homo sapiens_hsa000520.60072361
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.59996529
94Tight junction_Homo sapiens_hsa045300.59327131
95Primary immunodeficiency_Homo sapiens_hsa053400.57225421
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57097167
97Selenocompound metabolism_Homo sapiens_hsa004500.56963493
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55974489
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55646728
100Amoebiasis_Homo sapiens_hsa051460.54537571
101Melanogenesis_Homo sapiens_hsa049160.52621422
102Glucagon signaling pathway_Homo sapiens_hsa049220.52463826
103Vibrio cholerae infection_Homo sapiens_hsa051100.52408325
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51865787
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51123724
106Shigellosis_Homo sapiens_hsa051310.50977808
107T cell receptor signaling pathway_Homo sapiens_hsa046600.50977492
108Purine metabolism_Homo sapiens_hsa002300.49638908
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49593420
110TGF-beta signaling pathway_Homo sapiens_hsa043500.49009917
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.48761912
112Insulin signaling pathway_Homo sapiens_hsa049100.47978118
113Legionellosis_Homo sapiens_hsa051340.46263807
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45659235
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.44410670
116FoxO signaling pathway_Homo sapiens_hsa040680.44377424
117N-Glycan biosynthesis_Homo sapiens_hsa005100.44161798
118Melanoma_Homo sapiens_hsa052180.43288993
119Prolactin signaling pathway_Homo sapiens_hsa049170.41987960
120AMPK signaling pathway_Homo sapiens_hsa041520.41878211
121Platelet activation_Homo sapiens_hsa046110.41532405
122Endocytosis_Homo sapiens_hsa041440.40796613
123Influenza A_Homo sapiens_hsa051640.39368127
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37372230

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