SF3B3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.64835197
2nuclear pore organization (GO:0006999)5.46700872
3nuclear pore complex assembly (GO:0051292)5.40477883
4protein localization to kinetochore (GO:0034501)4.81789707
5IMP biosynthetic process (GO:0006188)4.54557061
6folic acid-containing compound biosynthetic process (GO:0009396)4.43848481
7mitotic nuclear envelope disassembly (GO:0007077)4.41646908
8DNA strand elongation involved in DNA replication (GO:0006271)4.33657367
9DNA replication initiation (GO:0006270)4.29021080
10membrane disassembly (GO:0030397)4.14502673
11nuclear envelope disassembly (GO:0051081)4.14502673
12DNA strand elongation (GO:0022616)4.10143034
13pore complex assembly (GO:0046931)4.09578605
14nucleobase biosynthetic process (GO:0046112)3.99114008
15DNA replication-dependent nucleosome organization (GO:0034723)3.98440452
16DNA replication-dependent nucleosome assembly (GO:0006335)3.98440452
17DNA duplex unwinding (GO:0032508)3.96526552
18DNA geometric change (GO:0032392)3.94308359
19IMP metabolic process (GO:0046040)3.93295836
20protein localization to chromosome, centromeric region (GO:0071459)3.89460748
21formation of translation preinitiation complex (GO:0001731)3.89239258
22pre-miRNA processing (GO:0031054)3.75734763
23mitotic chromosome condensation (GO:0007076)3.70764139
24regulation of translational fidelity (GO:0006450)3.70722502
25telomere maintenance via semi-conservative replication (GO:0032201)3.69913347
26chromosome condensation (GO:0030261)3.63750087
27regulation of histone H3-K9 methylation (GO:0051570)3.58234618
28negative regulation of histone methylation (GO:0031061)3.57270794
29sister chromatid segregation (GO:0000819)3.56933862
30dosage compensation (GO:0007549)3.55023353
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51182411
32heterochromatin organization (GO:0070828)3.50313822
33protein complex localization (GO:0031503)3.50071046
34maturation of SSU-rRNA (GO:0030490)3.47692493
35mitotic sister chromatid segregation (GO:0000070)3.47662661
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.43698958
37mitotic metaphase plate congression (GO:0007080)3.40500398
38mitotic sister chromatid cohesion (GO:0007064)3.39957573
39mitotic recombination (GO:0006312)3.39609272
40purine nucleobase biosynthetic process (GO:0009113)3.39109233
41regulation of centriole replication (GO:0046599)3.37032586
42establishment of integrated proviral latency (GO:0075713)3.36584617
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35555637
44ribosomal small subunit assembly (GO:0000028)3.35298380
45telomere maintenance via recombination (GO:0000722)3.34656827
46DNA replication checkpoint (GO:0000076)3.33948386
47regulation of spindle organization (GO:0090224)3.29894661
48positive regulation of chromosome segregation (GO:0051984)3.29690247
49non-recombinational repair (GO:0000726)3.28610497
50double-strand break repair via nonhomologous end joining (GO:0006303)3.28610497
51protein-DNA complex disassembly (GO:0032986)3.26359620
52nucleosome disassembly (GO:0006337)3.26359620
53nuclear envelope organization (GO:0006998)3.26300668
54negative regulation of RNA splicing (GO:0033119)3.25015710
55regulation of gene silencing by RNA (GO:0060966)3.24765977
56regulation of posttranscriptional gene silencing (GO:0060147)3.24765977
57regulation of gene silencing by miRNA (GO:0060964)3.24765977
58DNA packaging (GO:0006323)3.21614615
59cellular protein complex localization (GO:0034629)3.19843933
60spliceosomal tri-snRNP complex assembly (GO:0000244)3.19044924
61protein export from nucleus (GO:0006611)3.18372969
62ribosome assembly (GO:0042255)3.17776232
63translesion synthesis (GO:0019985)3.17646710
64chromatin assembly (GO:0031497)3.14734942
65DNA conformation change (GO:0071103)3.13438808
66metaphase plate congression (GO:0051310)3.11689039
67regulation of mammary gland epithelial cell proliferation (GO:0033599)3.10501259
68regulation of sister chromatid cohesion (GO:0007063)3.09425475
69telomere maintenance via telomere lengthening (GO:0010833)3.09241931
70regulation of translational termination (GO:0006449)3.08446801
71Golgi transport vesicle coating (GO:0048200)3.07617718
72COPI coating of Golgi vesicle (GO:0048205)3.07617718
73regulation of centrosome cycle (GO:0046605)3.06977527
74proline biosynthetic process (GO:0006561)3.06342852
75chromatin assembly or disassembly (GO:0006333)3.04235164
76attachment of spindle microtubules to kinetochore (GO:0008608)3.02788269
77DNA synthesis involved in DNA repair (GO:0000731)3.00965758
78viral transcription (GO:0019083)3.00540627
79translational termination (GO:0006415)2.99986291
80regulation of mitotic spindle organization (GO:0060236)2.99502114
81negative regulation of mRNA processing (GO:0050686)2.99452750
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99234913
83somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98657842
84somatic hypermutation of immunoglobulin genes (GO:0016446)2.98657842
85DNA replication-independent nucleosome assembly (GO:0006336)2.97714313
86DNA replication-independent nucleosome organization (GO:0034724)2.97714313
87protein localization to chromosome (GO:0034502)2.97108979
88ribosome biogenesis (GO:0042254)2.96723063
89DNA strand renaturation (GO:0000733)2.96214516
90postreplication repair (GO:0006301)2.95543824
91chromatin remodeling at centromere (GO:0031055)2.93890935
92chromosome segregation (GO:0007059)2.93593124
93negative regulation of DNA repair (GO:0045738)2.92723637
94viral mRNA export from host cell nucleus (GO:0046784)2.92625397
95histone H2A monoubiquitination (GO:0035518)2.92023870
96nucleotide-excision repair, DNA gap filling (GO:0006297)2.91837227
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91518690
98meiotic chromosome segregation (GO:0045132)2.90770764
99regulation of nucleobase-containing compound transport (GO:0032239)2.90514157
100translational initiation (GO:0006413)2.90402776
101regulation of chromosome segregation (GO:0051983)2.90044174
102kinetochore organization (GO:0051383)2.88834560
103regulation of centrosome duplication (GO:0010824)2.88733200
104peptidyl-arginine omega-N-methylation (GO:0035247)2.88286142
105mRNA transport (GO:0051028)2.87338998
106establishment of chromosome localization (GO:0051303)2.87027117
107regulation of DNA damage checkpoint (GO:2000001)2.86239392
108CENP-A containing nucleosome assembly (GO:0034080)2.84706128
109regulation of helicase activity (GO:0051095)2.84673822
110V(D)J recombination (GO:0033151)2.84195662
111regulation of RNA export from nucleus (GO:0046831)2.83682293
112* mRNA splicing, via spliceosome (GO:0000398)2.83298944
113* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83298944
114translational elongation (GO:0006414)2.82721718
115negative regulation of mRNA metabolic process (GO:1903312)2.82043100
116negative regulation of chromosome segregation (GO:0051985)2.81882612
117* RNA splicing, via transesterification reactions (GO:0000375)2.81867942
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.81451824
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.81451824
120positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.81451824
121regulation of histone H3-K27 methylation (GO:0061085)2.80818273
122peptidyl-arginine N-methylation (GO:0035246)2.80222179
123peptidyl-arginine methylation (GO:0018216)2.80222179
124histone arginine methylation (GO:0034969)2.79693306
125ATP-dependent chromatin remodeling (GO:0043044)2.79626699
126rRNA transcription (GO:0009303)2.79291412
127spindle assembly checkpoint (GO:0071173)2.78021790
128DNA topological change (GO:0006265)2.77474382
129RNA stabilization (GO:0043489)2.76278331
130mRNA stabilization (GO:0048255)2.76278331
131mRNA cleavage (GO:0006379)2.76059214
132ribonucleoprotein complex biogenesis (GO:0022613)2.75945359
133ribosomal large subunit biogenesis (GO:0042273)2.75620240
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75490414
135negative regulation of sister chromatid segregation (GO:0033046)2.75490414
136positive regulation of DNA-dependent DNA replication (GO:2000105)2.73543078
137RNA transport (GO:0050658)2.73405621
138establishment of RNA localization (GO:0051236)2.73405621
139nucleic acid transport (GO:0050657)2.73405621
140folic acid metabolic process (GO:0046655)2.72016748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.92317414
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.66858926
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.91539419
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73516952
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36938153
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.23066383
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97704375
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88572415
9MYC_22102868_ChIP-Seq_BL_Human2.54386281
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51092134
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24693473
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21967042
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21375693
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.15796441
15* XRN2_22483619_ChIP-Seq_HELA_Human2.15076055
16AR_21909140_ChIP-Seq_LNCAP_Human2.10328763
17* EST1_17652178_ChIP-ChIP_JURKAT_Human1.94657974
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.87512448
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85103310
20* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84532539
21CIITA_25753668_ChIP-Seq_RAJI_Human1.80180879
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80106595
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79323825
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76005518
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73779582
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65008376
27* VDR_23849224_ChIP-Seq_CD4+_Human1.64765836
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63949322
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.61806602
30FOXP3_21729870_ChIP-Seq_TREG_Human1.60739558
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59694038
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59690119
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55405744
34* TTF2_22483619_ChIP-Seq_HELA_Human1.54967859
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54277638
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53670204
37* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53383097
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52632057
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52092158
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49739878
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48685946
42* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47473791
43KDM5A_27292631_Chip-Seq_BREAST_Human1.46342558
44GABP_19822575_ChIP-Seq_HepG2_Human1.45900688
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45419731
46VDR_21846776_ChIP-Seq_THP-1_Human1.45272961
47DCP1A_22483619_ChIP-Seq_HELA_Human1.45035748
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43642869
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39173891
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37782358
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.34599879
52* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30927562
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30356401
54* ELK1_19687146_ChIP-ChIP_HELA_Human1.28081034
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.28031225
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27375791
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27293260
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26834504
59TFEB_21752829_ChIP-Seq_HELA_Human1.26313535
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.25257146
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23713183
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21234024
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18901947
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17562035
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16594849
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15738751
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14654634
68* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14126598
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13102022
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12171435
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11568944
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10919965
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10553266
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10388309
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08827878
76* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07967077
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06237690
78* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04538090
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04412035
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02949638
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02562824
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01032351
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.00574602
84TCF7_22412390_ChIP-Seq_EML_Mouse1.00542466
85TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99484017
86CLOCK_20551151_ChIP-Seq_293T_Human0.99482042
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98361139
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97459004
89UTX_26944678_Chip-Seq_JUKART_Human0.96333973
90* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96166726
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95852500
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95757437
93MAF_26560356_Chip-Seq_TH1_Human0.93528519
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92714319
95* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92210897
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91885441
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91885441
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91885441
99RACK7_27058665_Chip-Seq_MCF-7_Human0.91069795
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90037370
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89756353
102ZNF263_19887448_ChIP-Seq_K562_Human0.89425103
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88857687
104YY1_21170310_ChIP-Seq_MESCs_Mouse0.88499557
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88126880
106CHD1_26751641_Chip-Seq_LNCaP_Human0.88074463
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87739205
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87070062
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85852950
110MYB_26560356_Chip-Seq_TH1_Human0.85419904
111MYB_26560356_Chip-Seq_TH2_Human0.85033490
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85027252
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84282220
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83527210
115SPI1_23547873_ChIP-Seq_NB4_Human0.82840410
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79607914
117ATF3_27146783_Chip-Seq_COLON_Human0.79359678
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79008607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.09504745
2MP0003693_abnormal_embryo_hatching4.08365925
3MP0003111_abnormal_nucleus_morphology3.91347428
4MP0004957_abnormal_blastocyst_morpholog3.76222475
5MP0003077_abnormal_cell_cycle3.46805183
6MP0008057_abnormal_DNA_replication3.29479038
7MP0010352_gastrointestinal_tract_polyps3.19105251
8MP0008007_abnormal_cellular_replicative2.54183424
9MP0001730_embryonic_growth_arrest2.50652028
10MP0008058_abnormal_DNA_repair2.43605952
11MP0010307_abnormal_tumor_latency2.40683083
12MP0002396_abnormal_hematopoietic_system2.39821307
13MP0003123_paternal_imprinting2.38394215
14MP0000350_abnormal_cell_proliferation2.31980624
15MP0005076_abnormal_cell_differentiation2.19131381
16MP0003705_abnormal_hypodermis_morpholog2.08354683
17MP0008932_abnormal_embryonic_tissue2.05451279
18MP0002009_preneoplasia2.00159177
19MP0004808_abnormal_hematopoietic_stem1.92256737
20MP0001672_abnormal_embryogenesis/_devel1.86713226
21MP0005380_embryogenesis_phenotype1.86713226
22MP0004197_abnormal_fetal_growth/weight/1.85672435
23MP0001697_abnormal_embryo_size1.80110258
24MP0002084_abnormal_developmental_patter1.79961133
25MP0003984_embryonic_growth_retardation1.74146088
26MP0002088_abnormal_embryonic_growth/wei1.71543167
27MP0002085_abnormal_embryonic_tissue1.69987644
28MP0002080_prenatal_lethality1.65012140
29MP0000490_abnormal_crypts_of1.63256697
30MP0002086_abnormal_extraembryonic_tissu1.62402489
31MP0000537_abnormal_urethra_morphology1.61677661
32MP0001346_abnormal_lacrimal_gland1.58712108
33MP0008877_abnormal_DNA_methylation1.57873036
34MP0003121_genomic_imprinting1.56976390
35MP0003786_premature_aging1.49893560
36MP0003567_abnormal_fetal_cardiomyocyte1.43668301
37MP0009278_abnormal_bone_marrow1.42976897
38MP0010030_abnormal_orbit_morphology1.39972809
39MP0003566_abnormal_cell_adhesion1.36784710
40MP0000313_abnormal_cell_death1.35995490
41MP0006054_spinal_hemorrhage1.35059717
42MP0001293_anophthalmia1.34242916
43MP0002019_abnormal_tumor_incidence1.33900012
44MP0004185_abnormal_adipocyte_glucose1.31479639
45MP0001661_extended_life_span1.28939458
46MP0000703_abnormal_thymus_morphology1.28752113
47MP0003890_abnormal_embryonic-extraembry1.27987890
48MP0009053_abnormal_anal_canal1.27652535
49MP0001849_ear_inflammation1.25284808
50MP0003763_abnormal_thymus_physiology1.25210808
51MP0009697_abnormal_copulation1.24303042
52MP0005501_abnormal_skin_physiology1.21906596
53MP0005397_hematopoietic_system_phenotyp1.19954721
54MP0001545_abnormal_hematopoietic_system1.19954721
55MP0005023_abnormal_wound_healing1.19918029
56MP0000566_synostosis1.15038902
57MP0002398_abnormal_bone_marrow1.14011963
58MP0002877_abnormal_melanocyte_morpholog1.12655406
59MP0002796_impaired_skin_barrier1.12506371
60MP0010234_abnormal_vibrissa_follicle1.11844126
61MP0000733_abnormal_muscle_development1.11042215
62MP0003942_abnormal_urinary_system1.10726471
63MP0000579_abnormal_nail_morphology1.08901900
64MP0001915_intracranial_hemorrhage1.08312790
65MP0003119_abnormal_digestive_system1.05722635
66MP0002722_abnormal_immune_system1.03511163
67MP0009333_abnormal_splenocyte_physiolog1.02730299
68MP0009672_abnormal_birth_weight1.02065737
69MP0003385_abnormal_body_wall0.99077955
70MP0005451_abnormal_body_composition0.98964154
71MP0000428_abnormal_craniofacial_morphol0.98953009
72MP0005409_darkened_coat_color0.98851238
73MP0002098_abnormal_vibrissa_morphology0.98744376
74MP0000689_abnormal_spleen_morphology0.94082445
75MP0000003_abnormal_adipose_tissue0.93665495
76MP0002092_abnormal_eye_morphology0.93421685
77MP0009703_decreased_birth_body0.92539842
78MP0002249_abnormal_larynx_morphology0.91332958
79MP0002111_abnormal_tail_morphology0.88423708
80MP0002089_abnormal_postnatal_growth/wei0.87714229
81MP0003861_abnormal_nervous_system0.87677464
82MP0002653_abnormal_ependyma_morphology0.83514313
83MP0005621_abnormal_cell_physiology0.82158255
84MP0001348_abnormal_lacrimal_gland0.81703096
85MP0000627_abnormal_mammary_gland0.81605401
86MP0002429_abnormal_blood_cell0.81366505
87MP0002697_abnormal_eye_size0.80929446
88MP0000477_abnormal_intestine_morphology0.80803449
89MP0000534_abnormal_ureter_morphology0.80708552
90MP0002210_abnormal_sex_determination0.80682454
91MP0002925_abnormal_cardiovascular_devel0.80151120
92MP0003453_abnormal_keratinocyte_physiol0.80072605
93MP0005384_cellular_phenotype0.79615684
94MP0003115_abnormal_respiratory_system0.78798440
95MP0000377_abnormal_hair_follicle0.78428749
96MP0004272_abnormal_basement_membrane0.78364121
97MP0003937_abnormal_limbs/digits/tail_de0.77788789
98MP0010678_abnormal_skin_adnexa0.77510819
99MP0000858_altered_metastatic_potential0.77339628
100MP0003718_maternal_effect0.75969566
101MP0003300_gastrointestinal_ulcer0.75956280
102MP0002060_abnormal_skin_morphology0.75374300
103MP0002166_altered_tumor_susceptibility0.74624094
104MP0003315_abnormal_perineum_morphology0.74416325
105MP0004264_abnormal_extraembryonic_tissu0.74192263
106MP0001145_abnormal_male_reproductive0.73703709
107MP0000685_abnormal_immune_system0.72707924
108MP0000371_diluted_coat_color0.71974694
109MP0000716_abnormal_immune_system0.70414630
110MP0003755_abnormal_palate_morphology0.69923019
111MP0003935_abnormal_craniofacial_develop0.68751859
112MP0002114_abnormal_axial_skeleton0.68345210
113MP0003283_abnormal_digestive_organ0.67880489
114MP0010630_abnormal_cardiac_muscle0.67674927
115MP0001216_abnormal_epidermal_layer0.67559731
116MP0000383_abnormal_hair_follicle0.67547673
117MP0002075_abnormal_coat/hair_pigmentati0.66893075
118MP0002081_perinatal_lethality0.66671976
119MP0001800_abnormal_humoral_immune0.66584181
120MP0008770_decreased_survivor_rate0.65826170
121MP0000762_abnormal_tongue_morphology0.65660893
122MP0003221_abnormal_cardiomyocyte_apopto0.64562518
123MP0002006_tumorigenesis0.64471432
124MP0000432_abnormal_head_morphology0.64153968
125MP0001286_abnormal_eye_development0.63786272
126MP0005187_abnormal_penis_morphology0.62894243
127MP0000358_abnormal_cell_content/0.62728576
128MP0004233_abnormal_muscle_weight0.61717443
129MP0003943_abnormal_hepatobiliary_system0.61294457
130MP0005623_abnormal_meninges_morphology0.59779877
131MP0001873_stomach_inflammation0.59356233
132MP0003448_altered_tumor_morphology0.58216701
133MP0003941_abnormal_skin_development0.56820927
134MP0001835_abnormal_antigen_presentation0.56255610

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.00709090
2Selective tooth agenesis (HP:0001592)3.56841740
3Colon cancer (HP:0003003)3.48906181
4Medulloblastoma (HP:0002885)3.38629495
5Birth length less than 3rd percentile (HP:0003561)3.01534772
6Reticulocytopenia (HP:0001896)2.99242855
7Abnormality of the astrocytes (HP:0100707)2.95934394
8Astrocytoma (HP:0009592)2.95934394
9Proximal placement of thumb (HP:0009623)2.88004104
10Deviation of the thumb (HP:0009603)2.85996260
11Short 4th metacarpal (HP:0010044)2.84780295
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.84780295
13Increased nuchal translucency (HP:0010880)2.79298856
14Chromsome breakage (HP:0040012)2.76472744
15Basal cell carcinoma (HP:0002671)2.66572958
16Agnosia (HP:0010524)2.66079992
17Nephroblastoma (Wilms tumor) (HP:0002667)2.63572105
18Rhabdomyosarcoma (HP:0002859)2.63237994
19Septate vagina (HP:0001153)2.63236372
20Amaurosis fugax (HP:0100576)2.61207662
21Abnormal number of incisors (HP:0011064)2.60432749
22Asymmetry of the thorax (HP:0001555)2.58731229
23High anterior hairline (HP:0009890)2.55810875
24Patellar aplasia (HP:0006443)2.51338463
25Neoplasm of the oral cavity (HP:0100649)2.49568064
26Glioma (HP:0009733)2.48116256
27Degeneration of anterior horn cells (HP:0002398)2.47315226
28Abnormality of the anterior horn cell (HP:0006802)2.47315226
29Volvulus (HP:0002580)2.47224881
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46128332
31Abnormality of chromosome stability (HP:0003220)2.44361106
32Progressive muscle weakness (HP:0003323)2.41820486
33Embryonal renal neoplasm (HP:0011794)2.41052809
34Hyperacusis (HP:0010780)2.35874965
35Myelodysplasia (HP:0002863)2.34333452
36Insomnia (HP:0100785)2.33581011
37Microvesicular hepatic steatosis (HP:0001414)2.33421484
38Aplasia/Hypoplasia of the patella (HP:0006498)2.33315102
39Deep philtrum (HP:0002002)2.32802946
40Abnormality of cells of the erythroid lineage (HP:0012130)2.31116263
41Prominent nose (HP:0000448)2.30493280
42Biliary tract neoplasm (HP:0100574)2.28343731
43Thrombocytosis (HP:0001894)2.27539753
44Abnormality of the labia minora (HP:0012880)2.26666621
45Missing ribs (HP:0000921)2.26546860
46Heterotopia (HP:0002282)2.25940083
47Neoplasm of striated muscle (HP:0009728)2.25919414
48Dysmetric saccades (HP:0000641)2.25161347
49Neoplasm of the pancreas (HP:0002894)2.24652803
50Ectopic kidney (HP:0000086)2.22883219
51High pitched voice (HP:0001620)2.22000476
5211 pairs of ribs (HP:0000878)2.17835864
53Cutaneous melanoma (HP:0012056)2.15935343
54Meckel diverticulum (HP:0002245)2.14391376
55Cortical dysplasia (HP:0002539)2.13812575
56Oral leukoplakia (HP:0002745)2.10662768
57Ulnar bowing (HP:0003031)2.08456128
58Gastrointestinal carcinoma (HP:0002672)2.07557911
59Malignant gastrointestinal tract tumors (HP:0006749)2.07557911
60Renal duplication (HP:0000075)2.06241196
61Increased density of long bones (HP:0006392)2.05915119
62Abnormality of cochlea (HP:0000375)2.04846900
63Overriding aorta (HP:0002623)2.04603146
64Duplication of thumb phalanx (HP:0009942)2.04468793
65Abnormality of the ileum (HP:0001549)2.04298458
66Abnormal number of erythroid precursors (HP:0012131)2.03888120
67Atresia of the external auditory canal (HP:0000413)2.03412003
68Absent thumb (HP:0009777)2.02417672
69Cafe-au-lait spot (HP:0000957)2.02053807
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.01484195
71Ankle contracture (HP:0006466)2.00940531
72Breast hypoplasia (HP:0003187)2.00613850
73Progressive external ophthalmoplegia (HP:0000590)1.99331881
74Abnormality of the 4th metacarpal (HP:0010012)1.99062555
75Abnormality of the preputium (HP:0100587)1.97371805
76Abnormality of the calcaneus (HP:0008364)1.97288068
77Abnormality of the fingertips (HP:0001211)1.96341409
78Long eyelashes (HP:0000527)1.96068057
79Small intestinal stenosis (HP:0012848)1.95067526
80Duodenal stenosis (HP:0100867)1.95067526
81Elfin facies (HP:0004428)1.94347034
82Carpal bone hypoplasia (HP:0001498)1.93561856
83Urethral obstruction (HP:0000796)1.92583946
84Short thumb (HP:0009778)1.91188736
85Multiple enchondromatosis (HP:0005701)1.90651557
86Sparse lateral eyebrow (HP:0005338)1.88631412
87Abnormality of oral frenula (HP:0000190)1.88580138
88Absent radius (HP:0003974)1.84681346
89Ankyloglossia (HP:0010296)1.84450689
90Skin tags (HP:0010609)1.84408210
91Choanal atresia (HP:0000453)1.84068245
92Broad palm (HP:0001169)1.83987663
93Anal stenosis (HP:0002025)1.82902594
94Ovarian neoplasm (HP:0100615)1.82644483
95Abnormality of the carotid arteries (HP:0005344)1.82263733
96Obsessive-compulsive behavior (HP:0000722)1.82090324
97Abnormality of chromosome segregation (HP:0002916)1.81664520
98Abnormality of the distal phalanx of the thumb (HP:0009617)1.81299825
99Termporal pattern (HP:0011008)1.80991552
100Insidious onset (HP:0003587)1.80991552
101Duplicated collecting system (HP:0000081)1.80778096
102Hypopigmentation of the fundus (HP:0007894)1.80759059
103Poikiloderma (HP:0001029)1.80696208
104Broad distal phalanx of finger (HP:0009836)1.80351102
105Cutis marmorata (HP:0000965)1.79897578
106Tracheoesophageal fistula (HP:0002575)1.79835430
107Adenoma sebaceum (HP:0009720)1.79450670
108Angiofibromas (HP:0010615)1.79450670
109Embryonal neoplasm (HP:0002898)1.79011115
110Pelvic girdle muscle weakness (HP:0003749)1.78849285
111Capillary hemangiomas (HP:0005306)1.77502618
112Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77052899
113Neoplasm of the colon (HP:0100273)1.77011492
114Overlapping toe (HP:0001845)1.77005647
115Facial hemangioma (HP:0000329)1.76364720
116Preauricular skin tag (HP:0000384)1.75522117
117Microglossia (HP:0000171)1.75083497
118Squamous cell carcinoma (HP:0002860)1.73098430
119Skull defect (HP:0001362)1.73031747
120Bowel diverticulosis (HP:0005222)1.73002820
121Impulsivity (HP:0100710)1.72783298
122Smooth philtrum (HP:0000319)1.72408755
123Abnormality of DNA repair (HP:0003254)1.72276498
124Freckling (HP:0001480)1.70800143
125Abnormality of the duodenum (HP:0002246)1.70350961
126Trismus (HP:0000211)1.70246771
127Aplasia involving forearm bones (HP:0009822)1.69765619
128Absent forearm bone (HP:0003953)1.69765619
129Sloping forehead (HP:0000340)1.69592402
130Abnormality of reticulocytes (HP:0004312)1.69520031
131Abnormal lung lobation (HP:0002101)1.69390687
132Trigonocephaly (HP:0000243)1.68745055
133Aplastic anemia (HP:0001915)1.68345126
134Protrusio acetabuli (HP:0003179)1.67580157
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.67262659
136IgM deficiency (HP:0002850)1.67138777
137Slender long bone (HP:0003100)1.65674054
138Lymphoma (HP:0002665)1.65098604
139Spinal muscular atrophy (HP:0007269)1.64271836
140Sandal gap (HP:0001852)1.64003984
141Aplasia/hypoplasia of the humerus (HP:0006507)1.63677626
142Pointed chin (HP:0000307)1.63283103
143Abnormality of glycolysis (HP:0004366)1.63110202
144Abnormal gallbladder physiology (HP:0012438)1.62540475
145Cholecystitis (HP:0001082)1.62540475
146Renovascular hypertension (HP:0100817)1.62449727
147Patellar dislocation (HP:0002999)1.61544834
148Arteriovenous malformation (HP:0100026)1.61161745
149Horseshoe kidney (HP:0000085)1.60667788
150Spastic diplegia (HP:0001264)1.59985763
151Facial cleft (HP:0002006)1.58644381
152Limited elbow extension (HP:0001377)1.58103469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.31454537
2SMG13.61119560
3EEF2K3.52703337
4CDK123.29319714
5WEE13.21194011
6NEK22.73139288
7BUB12.63252603
8PASK2.47797598
9PKN22.47601169
10TSSK62.43256193
11MAP3K102.36120540
12RPS6KB22.13390370
13SCYL22.04886986
14NEK11.96198679
15TTK1.93652355
16TGFBR11.93638692
17PBK1.92946816
18TRIB31.82262085
19SRPK11.80749331
20EIF2AK11.74652209
21ATR1.70916234
22STK101.70339399
23BRD41.66540877
24ACVR1B1.65730815
25MKNK11.65021518
26CDK41.57669723
27CDK71.56712928
28MAP3K81.52112388
29PLK11.51814519
30FLT31.50036449
31TAF11.47098366
32AURKB1.42550470
33RPS6KA41.39197378
34TESK21.37306702
35EPHA21.36669374
36MAP4K11.35466673
37PAK41.35286011
38VRK21.35035320
39CHEK11.31496169
40ALK1.30480701
41ZAK1.27797644
42FGFR41.25465399
43IRAK31.24799410
44LRRK21.24081202
45PLK31.23450405
46BRSK21.22827760
47MST1R1.16544652
48CDK61.15025242
49CAMK1G1.14101463
50DYRK31.07850886
51CHEK21.07213389
52TTN1.05156876
53STK41.04265458
54CDK81.03086340
55SIK11.01140975
56EIF2AK30.99839369
57MTOR0.95007933
58CDK20.94304736
59ATM0.93033640
60PIM10.92743240
61TLK10.90673271
62PTK60.89425202
63MKNK20.88199813
64STK30.85448048
65LATS20.84408803
66MAP2K30.83655584
67NME20.82542660
68MAPK110.77622508
69PLK40.76910044
70VRK10.75087959
71MELK0.73911090
72BRSK10.73296114
73AURKA0.73121954
74PAK20.72009267
75FGFR10.71933217
76PDGFRA0.68616321
77JAK30.66302449
78LATS10.66272369
79CDK90.65235128
80BTK0.64358007
81CDK10.64166692
82EIF2AK20.62510211
83ERBB40.57376477
84KSR20.56063146
85PRPF4B0.55729574
86TESK10.53819572
87TYRO30.53623575
88ZAP700.53087882
89CSNK2A20.52277090
90GRK60.51935983
91NEK60.51581555
92CSF1R0.50860412
93RIPK10.50161927
94PAK10.47289564
95CHUK0.46773026
96AKT20.45272256
97NTRK10.44575317
98PRKDC0.44189644
99BMX0.44086106
100MAP3K90.43062920
101CSNK1D0.42745074
102CDK150.41477157
103RPS6KA50.40513761
104PTK20.40349991
105CDK180.39990325
106CSNK1E0.39254900
107RAF10.38798878
108CDK11A0.38693225
109NEK90.37815604
110ICK0.37075955
111ILK0.36850332
112GSK3B0.36552716
113MAPK140.35545264
114MAPKAPK30.35417774
115BRAF0.34763977
116RPS6KA10.33802297
117CSNK2A10.31822735
118CAMK1D0.31523232
119AKT10.31278694
120CSNK1A1L0.30497474
121MET0.29909609
122PNCK0.29838762
123CDK140.29617066
124MAPK10.29527447
125MAPK100.29336980
126KDR0.26951224
127CLK10.26040528
128CCNB10.25833671
129KIT0.24632333
130TAOK20.24286153
131RPS6KB10.23757334
132PRKCI0.23446521
133RPS6KC10.22526809

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61009665
2Mismatch repair_Homo sapiens_hsa034303.79314160
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20575167
4RNA transport_Homo sapiens_hsa030133.13853698
5* Spliceosome_Homo sapiens_hsa030403.11945043
6One carbon pool by folate_Homo sapiens_hsa006702.97200027
7Cell cycle_Homo sapiens_hsa041102.78739504
8Base excision repair_Homo sapiens_hsa034102.74531858
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71589149
10Nucleotide excision repair_Homo sapiens_hsa034202.40593828
11Homologous recombination_Homo sapiens_hsa034402.38980617
12Ribosome_Homo sapiens_hsa030102.14978686
13mRNA surveillance pathway_Homo sapiens_hsa030152.08671594
14Non-homologous end-joining_Homo sapiens_hsa034502.00191758
15RNA polymerase_Homo sapiens_hsa030201.95442255
16Fanconi anemia pathway_Homo sapiens_hsa034601.75637505
17RNA degradation_Homo sapiens_hsa030181.65986486
18p53 signaling pathway_Homo sapiens_hsa041151.63174231
19Pyrimidine metabolism_Homo sapiens_hsa002401.62327173
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55789938
21Systemic lupus erythematosus_Homo sapiens_hsa053221.48833564
22Viral carcinogenesis_Homo sapiens_hsa052031.44606151
23Proteasome_Homo sapiens_hsa030501.41969105
24Antigen processing and presentation_Homo sapiens_hsa046121.36402230
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35797274
26Epstein-Barr virus infection_Homo sapiens_hsa051691.24986829
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24983247
28Basal transcription factors_Homo sapiens_hsa030221.22115521
29Herpes simplex infection_Homo sapiens_hsa051681.19804052
30Carbon metabolism_Homo sapiens_hsa012001.18716970
31MicroRNAs in cancer_Homo sapiens_hsa052061.18534112
32HTLV-I infection_Homo sapiens_hsa051661.17987018
33Chronic myeloid leukemia_Homo sapiens_hsa052201.12313624
34Small cell lung cancer_Homo sapiens_hsa052221.12026069
35Vitamin B6 metabolism_Homo sapiens_hsa007501.09358073
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09292220
37Fructose and mannose metabolism_Homo sapiens_hsa000511.00245725
38Oocyte meiosis_Homo sapiens_hsa041140.93740358
39Colorectal cancer_Homo sapiens_hsa052100.92416032
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91367446
41Thyroid cancer_Homo sapiens_hsa052160.91343684
42Primary immunodeficiency_Homo sapiens_hsa053400.90795789
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89361753
44Notch signaling pathway_Homo sapiens_hsa043300.88867120
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88144789
46Legionellosis_Homo sapiens_hsa051340.87925498
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.86090786
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84055286
49Selenocompound metabolism_Homo sapiens_hsa004500.82927836
50Sulfur relay system_Homo sapiens_hsa041220.81743207
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80663304
52Glioma_Homo sapiens_hsa052140.78747814
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78654259
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78613947
55Hippo signaling pathway_Homo sapiens_hsa043900.77991682
56Apoptosis_Homo sapiens_hsa042100.77506834
57Basal cell carcinoma_Homo sapiens_hsa052170.76947235
58Pyruvate metabolism_Homo sapiens_hsa006200.76911528
59Steroid biosynthesis_Homo sapiens_hsa001000.76808609
60Biosynthesis of amino acids_Homo sapiens_hsa012300.76584573
61Hepatitis B_Homo sapiens_hsa051610.75651318
62mTOR signaling pathway_Homo sapiens_hsa041500.75429451
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.75149554
64Purine metabolism_Homo sapiens_hsa002300.74803542
65Adherens junction_Homo sapiens_hsa045200.74361964
66Measles_Homo sapiens_hsa051620.74056730
67Viral myocarditis_Homo sapiens_hsa054160.74052959
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73362582
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71320389
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.69072290
71Non-small cell lung cancer_Homo sapiens_hsa052230.68603741
72Acute myeloid leukemia_Homo sapiens_hsa052210.68519806
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66911966
74Bladder cancer_Homo sapiens_hsa052190.65674659
75TGF-beta signaling pathway_Homo sapiens_hsa043500.65642719
76Proteoglycans in cancer_Homo sapiens_hsa052050.64639406
77Renal cell carcinoma_Homo sapiens_hsa052110.64551386
78Shigellosis_Homo sapiens_hsa051310.63733545
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63531144
80AMPK signaling pathway_Homo sapiens_hsa041520.62906878
81Lysine degradation_Homo sapiens_hsa003100.62535459
82Alcoholism_Homo sapiens_hsa050340.62390738
83ErbB signaling pathway_Homo sapiens_hsa040120.60318859
84Insulin signaling pathway_Homo sapiens_hsa049100.60267954
85B cell receptor signaling pathway_Homo sapiens_hsa046620.60068012
86Pancreatic cancer_Homo sapiens_hsa052120.58990258
87T cell receptor signaling pathway_Homo sapiens_hsa046600.55159732
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54970384
89Melanoma_Homo sapiens_hsa052180.54009519
90HIF-1 signaling pathway_Homo sapiens_hsa040660.53975721
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53813674
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53741694
93Pathways in cancer_Homo sapiens_hsa052000.53076317
94Endometrial cancer_Homo sapiens_hsa052130.52131309
95Influenza A_Homo sapiens_hsa051640.50925375
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.50186759
97Prostate cancer_Homo sapiens_hsa052150.49642058
98Pentose phosphate pathway_Homo sapiens_hsa000300.48806389
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48636403
100Leishmaniasis_Homo sapiens_hsa051400.48234382
101Toxoplasmosis_Homo sapiens_hsa051450.47572518
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46995301
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46989592
104Fatty acid biosynthesis_Homo sapiens_hsa000610.46340143
105Inositol phosphate metabolism_Homo sapiens_hsa005620.44796985
106N-Glycan biosynthesis_Homo sapiens_hsa005100.44461722
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44103848
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.43921853
109Hedgehog signaling pathway_Homo sapiens_hsa043400.43820491
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.42553915
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40864384
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40401797
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40101472
114Galactose metabolism_Homo sapiens_hsa000520.38004829
115Hematopoietic cell lineage_Homo sapiens_hsa046400.37255432
116Glucagon signaling pathway_Homo sapiens_hsa049220.36257629
117Focal adhesion_Homo sapiens_hsa045100.35593659
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.35169102
119Arginine biosynthesis_Homo sapiens_hsa002200.31933102
120FoxO signaling pathway_Homo sapiens_hsa040680.31212161
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.31210060
122VEGF signaling pathway_Homo sapiens_hsa043700.30864859
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30748392
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30114970
125Allograft rejection_Homo sapiens_hsa053300.29998881
126TNF signaling pathway_Homo sapiens_hsa046680.28988185
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28258709
128Wnt signaling pathway_Homo sapiens_hsa043100.27557900
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26293710
130Tight junction_Homo sapiens_hsa045300.26208769

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