SF3B4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.72447641
2COPI coating of Golgi vesicle (GO:0048205)4.67306018
3Golgi transport vesicle coating (GO:0048200)4.67306018
4DNA unwinding involved in DNA replication (GO:0006268)4.66878356
5formation of translation preinitiation complex (GO:0001731)4.65686080
6DNA deamination (GO:0045006)4.53206611
7DNA strand elongation (GO:0022616)4.47250453
8telomere maintenance via semi-conservative replication (GO:0032201)4.34061793
9DNA replication initiation (GO:0006270)4.25519798
10maturation of SSU-rRNA (GO:0030490)4.17393517
11viral transcription (GO:0019083)4.13495231
12translational termination (GO:0006415)4.03496046
13protein localization to kinetochore (GO:0034501)4.01677349
14DNA replication checkpoint (GO:0000076)3.93439737
15folic acid-containing compound biosynthetic process (GO:0009396)3.92736341
16ribosomal small subunit assembly (GO:0000028)3.92642158
17ribosomal small subunit biogenesis (GO:0042274)3.82115140
18translational initiation (GO:0006413)3.80990666
19mitotic nuclear envelope disassembly (GO:0007077)3.80432513
20translational elongation (GO:0006414)3.75438847
21ribosome biogenesis (GO:0042254)3.73771908
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.73346225
23telomere maintenance via recombination (GO:0000722)3.72463714
24protein maturation by protein folding (GO:0022417)3.72235113
25ribonucleoprotein complex biogenesis (GO:0022613)3.68803762
26ribosomal large subunit biogenesis (GO:0042273)3.68621934
27pentose-phosphate shunt (GO:0006098)3.67931429
28nucleobase biosynthetic process (GO:0046112)3.67930404
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.62421961
30mitotic chromosome condensation (GO:0007076)3.61826473
31DNA replication-dependent nucleosome assembly (GO:0006335)3.60435357
32DNA replication-dependent nucleosome organization (GO:0034723)3.60435357
33nuclear envelope reassembly (GO:0031468)3.59235337
34mitotic nuclear envelope reassembly (GO:0007084)3.59235337
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55986944
36regulation of mammary gland epithelial cell proliferation (GO:0033599)3.53840180
37protein localization to chromosome, centromeric region (GO:0071459)3.52921683
38nuclear envelope disassembly (GO:0051081)3.52881953
39membrane disassembly (GO:0030397)3.52881953
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51868553
41mitotic recombination (GO:0006312)3.50397273
42telomere maintenance via telomere lengthening (GO:0010833)3.50333480
43spliceosomal snRNP assembly (GO:0000387)3.46540029
44IMP biosynthetic process (GO:0006188)3.44651021
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43684701
46regulation of translational termination (GO:0006449)3.40746633
47mitotic metaphase plate congression (GO:0007080)3.38793747
48NIK/NF-kappaB signaling (GO:0038061)3.38677338
49proline biosynthetic process (GO:0006561)3.37042328
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36722882
51ribosome assembly (GO:0042255)3.36044382
52establishment of viral latency (GO:0019043)3.35539005
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.30007363
54purine nucleobase biosynthetic process (GO:0009113)3.28395876
55rRNA processing (GO:0006364)3.28121510
56protein targeting to ER (GO:0045047)3.26343397
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.25539468
58negative regulation of RNA splicing (GO:0033119)3.25225794
59cotranslational protein targeting to membrane (GO:0006613)3.25065313
60cellular protein complex disassembly (GO:0043624)3.23521822
61viral life cycle (GO:0019058)3.23429196
62NADPH regeneration (GO:0006740)3.19490582
63mitotic sister chromatid segregation (GO:0000070)3.17522551
64rRNA metabolic process (GO:0016072)3.17345634
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16270286
66peptidyl-arginine omega-N-methylation (GO:0035247)3.12360026
67heterochromatin organization (GO:0070828)3.11910985
68protein retention in ER lumen (GO:0006621)3.09017504
69proteasome assembly (GO:0043248)3.08575307
70pseudouridine synthesis (GO:0001522)3.07793819
71establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07701400
72protein complex disassembly (GO:0043241)3.05834613
733-UTR-mediated mRNA stabilization (GO:0070935)3.05678507
74* RNA splicing, via transesterification reactions (GO:0000375)3.05642126
75* mRNA splicing, via spliceosome (GO:0000398)3.04201697
76* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.04201697
77peptidyl-arginine methylation (GO:0018216)3.03744751
78peptidyl-arginine N-methylation (GO:0035246)3.03744751
79protein localization to endoplasmic reticulum (GO:0070972)3.03696640
80regulation of translational fidelity (GO:0006450)3.01882833
81glucose catabolic process (GO:0006007)3.00609390
82histone arginine methylation (GO:0034969)2.98895912
83pentose metabolic process (GO:0019321)2.98753523
84retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97977326
85negative regulation of mRNA processing (GO:0050686)2.95885766
86termination of RNA polymerase II transcription (GO:0006369)2.95620029
87IMP metabolic process (GO:0046040)2.94946170
88folic acid metabolic process (GO:0046655)2.94556712
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93464619
90establishment of integrated proviral latency (GO:0075713)2.91395646
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91201359
92nuclear pore organization (GO:0006999)2.90290240
93DNA duplex unwinding (GO:0032508)2.89727546
94DNA replication-independent nucleosome organization (GO:0034724)2.88935557
95DNA replication-independent nucleosome assembly (GO:0006336)2.88935557
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.88866278
97macromolecular complex disassembly (GO:0032984)2.88428714
98regulation of posttranscriptional gene silencing (GO:0060147)2.88222797
99regulation of gene silencing by miRNA (GO:0060964)2.88222797
100regulation of gene silencing by RNA (GO:0060966)2.88222797
101nucleobase-containing small molecule interconversion (GO:0015949)2.88074702
102chromatin remodeling at centromere (GO:0031055)2.88000587
103spliceosomal complex assembly (GO:0000245)2.87864458
104nuclear-transcribed mRNA catabolic process (GO:0000956)2.87751042
105translation (GO:0006412)2.87685432
106CENP-A containing nucleosome assembly (GO:0034080)2.87395325
107DNA geometric change (GO:0032392)2.87274997
108negative regulation of cell size (GO:0045792)2.84636806
109metaphase plate congression (GO:0051310)2.83737763
110nuclear envelope organization (GO:0006998)2.82767976
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82472272
112viral mRNA export from host cell nucleus (GO:0046784)2.82132195
113negative regulation of chromosome segregation (GO:0051985)2.81886520
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81465734
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.81465734
116transcription-coupled nucleotide-excision repair (GO:0006283)2.81067258
117negative regulation of mRNA metabolic process (GO:1903312)2.81036942
118base-excision repair (GO:0006284)2.80530324
119sister chromatid segregation (GO:0000819)2.77688082
120RNA catabolic process (GO:0006401)2.74512963
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74203170
122positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.74156395
123GDP-mannose metabolic process (GO:0019673)2.73828902
124regulation of double-strand break repair via homologous recombination (GO:0010569)2.72655940
125G1/S transition of mitotic cell cycle (GO:0000082)2.72449416
126cell cycle G1/S phase transition (GO:0044843)2.72449416
127negative regulation of mitotic sister chromatid separation (GO:2000816)2.72401851
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.72401851
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.72401851
130negative regulation of sister chromatid segregation (GO:0033046)2.72401851
131negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.67249529
132protein complex localization (GO:0031503)2.66620958
133modulation by virus of host process (GO:0019054)2.66593454
134apoptotic process involved in morphogenesis (GO:0060561)2.64046084
135rRNA transcription (GO:0009303)2.63205419
136pyrimidine-containing compound salvage (GO:0008655)2.53223593
137pyrimidine nucleoside salvage (GO:0043097)2.53223593
138positive regulation of Cdc42 GTPase activity (GO:0043089)2.51855832
139negative regulation of ligase activity (GO:0051352)2.49032156
140negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49032156
141regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.48482392
142intracellular estrogen receptor signaling pathway (GO:0030520)2.47933977
143nucleosome disassembly (GO:0006337)2.47012099
144protein-DNA complex disassembly (GO:0032986)2.47012099
145deoxyribonucleotide biosynthetic process (GO:0009263)2.44105693
146deoxyribose phosphate biosynthetic process (GO:0046385)2.43797819
1472-deoxyribonucleotide biosynthetic process (GO:0009265)2.43797819
148regulation of chromatin binding (GO:0035561)2.43079939
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.41560789
150cellular protein complex localization (GO:0034629)2.40635017
151modulation by symbiont of host cellular process (GO:0044068)2.39965169
152positive regulation of DNA-dependent DNA replication (GO:2000105)2.39597760
153negative regulation of DNA-templated transcription, elongation (GO:0032785)2.37307644
154pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.37232307
155pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.36948472
156tRNA methylation (GO:0030488)2.36244170
157negative regulation of B cell apoptotic process (GO:0002903)2.35079846
158chaperone mediated protein folding requiring cofactor (GO:0051085)2.34770837
159pinocytosis (GO:0006907)2.34585184
160glucose 6-phosphate metabolic process (GO:0051156)2.33914065
161activation of Rac GTPase activity (GO:0032863)2.33705804
162DNA topological change (GO:0006265)2.32665706
163pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.32610227
164cellular response to interleukin-4 (GO:0071353)2.30665083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.10813736
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.16458681
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96221039
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.57019388
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04162621
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99027622
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80950392
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76154085
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70276768
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.59534913
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.57131414
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47123108
13XRN2_22483619_ChIP-Seq_HELA_Human2.45494710
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41079893
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.40553199
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29831712
17MYC_22102868_ChIP-Seq_BL_Human2.23639638
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19282108
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.16853232
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16562924
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15399207
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02363647
23ZNF263_19887448_ChIP-Seq_K562_Human1.96439218
24VDR_23849224_ChIP-Seq_CD4+_Human1.91588243
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90601997
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89785159
27DCP1A_22483619_ChIP-Seq_HELA_Human1.87605138
28* GABP_19822575_ChIP-Seq_HepG2_Human1.82527460
29* TTF2_22483619_ChIP-Seq_HELA_Human1.79152276
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.72383322
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72355920
32AR_21909140_ChIP-Seq_LNCAP_Human1.71401794
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70416139
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70316484
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69613533
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.69263657
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67136903
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67019715
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66997682
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65280772
41LXR_22292898_ChIP-Seq_THP-1_Human1.65053319
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.62644384
43RACK7_27058665_Chip-Seq_MCF-7_Human1.62349047
44CIITA_25753668_ChIP-Seq_RAJI_Human1.61043151
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57657518
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56763303
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55985758
48VDR_21846776_ChIP-Seq_THP-1_Human1.55299256
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.51662953
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51470980
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51456108
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49768888
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49705314
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48872081
55* KDM5A_27292631_Chip-Seq_BREAST_Human1.44847196
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40082973
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39906057
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39601308
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37874387
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36243850
61* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35258051
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.33717437
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32996707
64* TET1_21451524_ChIP-Seq_MESCs_Mouse1.32822268
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30595449
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29384982
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26842997
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25769640
69TFEB_21752829_ChIP-Seq_HELA_Human1.25408260
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25366652
71* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25343205
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22962178
73TCF7_22412390_ChIP-Seq_EML_Mouse1.21620385
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21531799
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20428041
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20428041
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20428041
78* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19263783
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18521730
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18335618
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18105236
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17595220
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17240628
84P68_20966046_ChIP-Seq_HELA_Human1.16659413
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15582554
86KDM2B_26808549_Chip-Seq_DND41_Human1.15383235
87MAF_26560356_Chip-Seq_TH2_Human1.14440940
88ELK1_19687146_ChIP-ChIP_HELA_Human1.14294191
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14079197
90* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14064481
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10933668
92VDR_24763502_ChIP-Seq_THP-1_Human1.10225635
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.10038905
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09554585
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09534812
96* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08891608
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07266151
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07138639
99NCOR1_26117541_ChIP-Seq_K562_Human1.06575294
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.06159993
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05860565
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04782375
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04347352
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.02518393
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01871005
106* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01457355
107ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00513571
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99940022
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99867420
110RUNX1_22412390_ChIP-Seq_EML_Mouse0.99308741
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.98846860
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98776593
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98559409
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97299904
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.96743205
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94527577
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94505869
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94374400
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93185161
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.92693169
121* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92276939
122* SPI1_23547873_ChIP-Seq_NB4_Human0.91316507
123SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90191285
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.89945431
125UTX_26944678_Chip-Seq_JUKART_Human0.89890464
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88880453
127MAF_26560356_Chip-Seq_TH1_Human0.88182771
128ATF3_27146783_Chip-Seq_COLON_Human0.88127826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.81561032
2MP0004957_abnormal_blastocyst_morpholog4.25080066
3MP0003111_abnormal_nucleus_morphology4.08022124
4MP0010094_abnormal_chromosome_stability3.78627874
5MP0003077_abnormal_cell_cycle3.55510024
6MP0008057_abnormal_DNA_replication3.05788504
7MP0002877_abnormal_melanocyte_morpholog2.97503696
8MP0010352_gastrointestinal_tract_polyps2.79983630
9MP0008007_abnormal_cellular_replicative2.74191420
10MP0008932_abnormal_embryonic_tissue2.69185811
11MP0010030_abnormal_orbit_morphology2.59100773
12MP0008058_abnormal_DNA_repair2.47665599
13MP0001730_embryonic_growth_arrest2.36505198
14MP0005058_abnormal_lysosome_morphology2.29291451
15MP0000350_abnormal_cell_proliferation2.28589394
16MP0003123_paternal_imprinting2.20142444
17MP0008260_abnormal_autophagy2.09682350
18MP0005451_abnormal_body_composition2.08766110
19MP0002796_impaired_skin_barrier2.05302444
20MP0002396_abnormal_hematopoietic_system1.97056095
21MP0000490_abnormal_crypts_of1.85145271
22MP0001697_abnormal_embryo_size1.84545313
23MP0005380_embryogenesis_phenotype1.76504210
24MP0001672_abnormal_embryogenesis/_devel1.76504210
25MP0002085_abnormal_embryonic_tissue1.67189475
26MP0002080_prenatal_lethality1.65329415
27MP0004858_abnormal_nervous_system1.64923804
28MP0005076_abnormal_cell_differentiation1.63797584
29MP0003786_premature_aging1.63355068
30MP0009333_abnormal_splenocyte_physiolog1.63094106
31MP0003984_embryonic_growth_retardation1.61264400
32MP0004185_abnormal_adipocyte_glucose1.59966994
33MP0002653_abnormal_ependyma_morphology1.59633555
34MP0002088_abnormal_embryonic_growth/wei1.58379840
35MP0010307_abnormal_tumor_latency1.57356433
36MP0002084_abnormal_developmental_patter1.55016596
37MP0000313_abnormal_cell_death1.49673532
38MP0002086_abnormal_extraembryonic_tissu1.46741689
39MP0001348_abnormal_lacrimal_gland1.45872742
40MP0005397_hematopoietic_system_phenotyp1.45007056
41MP0001545_abnormal_hematopoietic_system1.45007056
42MP0004197_abnormal_fetal_growth/weight/1.43795624
43MP0002019_abnormal_tumor_incidence1.42792564
44MP0003763_abnormal_thymus_physiology1.41563334
45MP0004808_abnormal_hematopoietic_stem1.39611475
46MP0005623_abnormal_meninges_morphology1.37445562
47MP0004133_heterotaxia1.36510446
48MP0003119_abnormal_digestive_system1.34441625
49MP0003705_abnormal_hypodermis_morpholog1.32278254
50MP0003453_abnormal_keratinocyte_physiol1.31833178
51MP0009278_abnormal_bone_marrow1.31052026
52MP0008877_abnormal_DNA_methylation1.30702741
53MP0000703_abnormal_thymus_morphology1.29941293
54MP0003191_abnormal_cellular_cholesterol1.28388281
55MP0001293_anophthalmia1.27690535
56MP0009840_abnormal_foam_cell1.27252831
57MP0001873_stomach_inflammation1.26818593
58MP0003890_abnormal_embryonic-extraembry1.20819835
59MP0002060_abnormal_skin_morphology1.19854461
60MP0000858_altered_metastatic_potential1.19567309
61MP0004947_skin_inflammation1.18119058
62MP0004264_abnormal_extraembryonic_tissu1.17121439
63MP0002398_abnormal_bone_marrow1.15966643
64MP0005257_abnormal_intraocular_pressure1.14736526
65MP0002722_abnormal_immune_system1.14411441
66MP0005023_abnormal_wound_healing1.13646788
67MP0001216_abnormal_epidermal_layer1.12512898
68MP0003567_abnormal_fetal_cardiomyocyte1.11203037
69MP0010234_abnormal_vibrissa_follicle1.11067985
70MP0001881_abnormal_mammary_gland1.10164534
71MP0002132_abnormal_respiratory_system1.07699474
72MP0000689_abnormal_spleen_morphology1.07077106
73MP0001853_heart_inflammation1.06829173
74MP0009053_abnormal_anal_canal1.06228901
75MP0000537_abnormal_urethra_morphology1.05060455
76MP0001835_abnormal_antigen_presentation1.03345067
77MP0004381_abnormal_hair_follicle1.02461877
78MP0005464_abnormal_platelet_physiology1.00551489
79MP0009931_abnormal_skin_appearance0.99271608
80MP0002089_abnormal_postnatal_growth/wei0.95344836
81MP0002111_abnormal_tail_morphology0.94507342
82MP0005000_abnormal_immune_tolerance0.94127639
83MP0002210_abnormal_sex_determination0.93962836
84MP0003121_genomic_imprinting0.93767464
85MP0001346_abnormal_lacrimal_gland0.92587249
86MP0003186_abnormal_redox_activity0.92334827
87MP0000358_abnormal_cell_content/0.92113172
88MP0003315_abnormal_perineum_morphology0.91954979
89MP0001727_abnormal_embryo_implantation0.91291379
90MP0008438_abnormal_cutaneous_collagen0.91154735
91MP0001849_ear_inflammation0.91080349
92MP0000627_abnormal_mammary_gland0.90718218
93MP0005025_abnormal_response_to0.90528395
94MP0002429_abnormal_blood_cell0.90507007
95MP0003566_abnormal_cell_adhesion0.90104877
96MP0001145_abnormal_male_reproductive0.88275580
97MP0006292_abnormal_olfactory_placode0.88069124
98MP0003718_maternal_effect0.87466203
99MP0002405_respiratory_system_inflammati0.86679825
100MP0002098_abnormal_vibrissa_morphology0.85706106
101MP0003941_abnormal_skin_development0.83820556
102MP0001819_abnormal_immune_cell0.83488707
103MP0002420_abnormal_adaptive_immunity0.83356559
104MP0002148_abnormal_hypersensitivity_rea0.81333106
105MP0001243_abnormal_dermal_layer0.80981632
106MP0009672_abnormal_birth_weight0.80635298
107MP0000428_abnormal_craniofacial_morphol0.79745159
108MP0005384_cellular_phenotype0.78768257
109MP0004782_abnormal_surfactant_physiolog0.78345509
110MP0000477_abnormal_intestine_morphology0.77777806
111MP0005621_abnormal_cell_physiology0.77303597
112MP0002723_abnormal_immune_serum0.77282169
113MP0002160_abnormal_reproductive_system0.77053883
114MP0006035_abnormal_mitochondrial_morpho0.76263091
115MP0002452_abnormal_antigen_presenting0.76197510
116MP0000049_abnormal_middle_ear0.76050599
117MP0000716_abnormal_immune_system0.75927820
118MP0000003_abnormal_adipose_tissue0.75365190
119MP0001915_intracranial_hemorrhage0.74739390
120MP0003448_altered_tumor_morphology0.74279560
121MP0000750_abnormal_muscle_regeneration0.73334483
122MP0000685_abnormal_immune_system0.71409696
123MP0000733_abnormal_muscle_development0.71369524
124MP0006054_spinal_hemorrhage0.71330564
125MP0003806_abnormal_nucleotide_metabolis0.70703432
126MP0002092_abnormal_eye_morphology0.70697761
127MP0003436_decreased_susceptibility_to0.67465700
128MP0008770_decreased_survivor_rate0.66246199
129MP0000653_abnormal_sex_gland0.65822452
130MP0005501_abnormal_skin_physiology0.65342590
131MP0008789_abnormal_olfactory_epithelium0.64708613
132MP0002932_abnormal_joint_morphology0.63196645
133MP0001929_abnormal_gametogenesis0.63044247
134MP0001286_abnormal_eye_development0.62289251
135MP0004233_abnormal_muscle_weight0.61848206
136MP0000678_abnormal_parathyroid_gland0.61514962
137MP0003303_peritoneal_inflammation0.60867397
138MP0002925_abnormal_cardiovascular_devel0.60618253
139MP0000432_abnormal_head_morphology0.60264116
140MP0001119_abnormal_female_reproductive0.59680857
141MP0005389_reproductive_system_phenotype0.58202385
142MP0003942_abnormal_urinary_system0.58186543
143MP0009703_decreased_birth_body0.58134233

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.12045137
2Breast hypoplasia (HP:0003187)4.01524350
3Reticulocytopenia (HP:0001896)4.00728812
4Abnormality of the anterior horn cell (HP:0006802)3.87391993
5Degeneration of anterior horn cells (HP:0002398)3.87391993
6Abnormality of cells of the erythroid lineage (HP:0012130)3.82861512
7Abnormal number of erythroid precursors (HP:0012131)3.69488849
8Selective tooth agenesis (HP:0001592)3.61062939
9Vertebral compression fractures (HP:0002953)3.40509869
10Patellar aplasia (HP:0006443)3.35506471
11Hyperacusis (HP:0010780)3.32760819
12Oral leukoplakia (HP:0002745)3.20819444
13Aplasia/Hypoplasia of the patella (HP:0006498)3.17868946
14Progressive muscle weakness (HP:0003323)3.10347213
15Colon cancer (HP:0003003)3.07258451
16Carpal bone hypoplasia (HP:0001498)3.04635663
17Multiple enchondromatosis (HP:0005701)3.00678893
18Ependymoma (HP:0002888)3.00181546
19Rough bone trabeculation (HP:0100670)2.93523779
20Ragged-red muscle fibers (HP:0003200)2.93491067
21Microvesicular hepatic steatosis (HP:0001414)2.87250841
22Achilles tendon contracture (HP:0001771)2.87086792
23Pallor (HP:0000980)2.79631558
24Long palpebral fissure (HP:0000637)2.74504085
25Macrocytic anemia (HP:0001972)2.74402167
26Atrophy/Degeneration involving motor neurons (HP:0007373)2.73300691
27Abnormal gallbladder physiology (HP:0012438)2.72194964
28Cholecystitis (HP:0001082)2.72194964
29Cerebral hypomyelination (HP:0006808)2.69642850
30Distal lower limb muscle weakness (HP:0009053)2.65332075
31Premature rupture of membranes (HP:0001788)2.65275627
32Basal cell carcinoma (HP:0002671)2.60675027
33Microretrognathia (HP:0000308)2.60556353
34Abnormality of the distal phalanges of the toes (HP:0010182)2.58785472
35Aplastic anemia (HP:0001915)2.56774334
36Medulloblastoma (HP:0002885)2.55650481
37Abnormal number of incisors (HP:0011064)2.51242876
38Abnormality of the Achilles tendon (HP:0005109)2.49820163
39Meckel diverticulum (HP:0002245)2.46996183
40Abnormality of the ileum (HP:0001549)2.46382935
41Neoplasm of the pancreas (HP:0002894)2.45561481
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44519678
43* Trismus (HP:0000211)2.42736460
44Abnormal umbilical cord blood vessels (HP:0011403)2.38663674
45Single umbilical artery (HP:0001195)2.38663674
46Abnormality of the fetal cardiovascular system (HP:0010948)2.38663674
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35294115
48Petechiae (HP:0000967)2.35204791
49J-shaped sella turcica (HP:0002680)2.33592867
50Premature graying of hair (HP:0002216)2.33203925
51Distal upper limb amyotrophy (HP:0007149)2.32293639
52Upper limb amyotrophy (HP:0009129)2.32293639
53Glossoptosis (HP:0000162)2.30997311
54Broad face (HP:0000283)2.28157174
55Insomnia (HP:0100785)2.27034803
56Rhabdomyosarcoma (HP:0002859)2.26693770
57Hypertensive crisis (HP:0100735)2.23172909
58Septate vagina (HP:0001153)2.22863102
59Abnormality of abdominal situs (HP:0011620)2.22683125
60Abdominal situs inversus (HP:0003363)2.22683125
61Distal lower limb amyotrophy (HP:0008944)2.21127292
62Tracheoesophageal fistula (HP:0002575)2.19388882
63Premature ovarian failure (HP:0008209)2.18724064
6411 pairs of ribs (HP:0000878)2.18279649
65Fasciculations (HP:0002380)2.17932199
66Slender long bone (HP:0003100)2.17696464
67Nonimmune hydrops fetalis (HP:0001790)2.17282640
68Broad distal phalanx of finger (HP:0009836)2.17154021
69Increased density of long bones (HP:0006392)2.14529401
70Proximal placement of thumb (HP:0009623)2.14341375
71Abnormality of the labia minora (HP:0012880)2.13738146
72Abnormality of the preputium (HP:0100587)2.13616131
73Hepatosplenomegaly (HP:0001433)2.13168077
74Supernumerary spleens (HP:0009799)2.11379608
75Micronodular cirrhosis (HP:0001413)2.11303206
76Aplasia/hypoplasia of the humerus (HP:0006507)2.11186792
77Increased nuchal translucency (HP:0010880)2.09747902
78Horseshoe kidney (HP:0000085)2.08851807
79Missing ribs (HP:0000921)2.07820720
80Chromsome breakage (HP:0040012)2.07423885
81Rib fusion (HP:0000902)2.07293792
82Agnosia (HP:0010524)2.07191076
83Deviation of the thumb (HP:0009603)2.06851629
84* Atresia of the external auditory canal (HP:0000413)2.06657992
85Protrusio acetabuli (HP:0003179)2.06458122
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.05179239
87* Absent thumb (HP:0009777)2.03976010
88Myelodysplasia (HP:0002863)2.03030337
89Small intestinal stenosis (HP:0012848)2.01507541
90Duodenal stenosis (HP:0100867)2.01507541
91Tongue fasciculations (HP:0001308)2.00734941
92Centrally nucleated skeletal muscle fibers (HP:0003687)2.00015020
93Generalized amyotrophy (HP:0003700)1.99469255
94Abnormal trabecular bone morphology (HP:0100671)1.99334234
95Abnormality of reticulocytes (HP:0004312)1.98263948
96Neoplasm of striated muscle (HP:0009728)1.97849556
97* Absent radius (HP:0003974)1.96906797
98Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95758058
99Hyperparathyroidism (HP:0000843)1.95620506
100Hypokinesia (HP:0002375)1.94744567
101Testicular atrophy (HP:0000029)1.94248020
102Fatigue (HP:0012378)1.94113451
103Reticulocytosis (HP:0001923)1.92755106
104Spinal muscular atrophy (HP:0007269)1.92321870
105Abnormal lung lobation (HP:0002101)1.92133742
106Bone marrow hypocellularity (HP:0005528)1.91940550
107Ulnar bowing (HP:0003031)1.89660172
108Hand muscle atrophy (HP:0009130)1.89654619
109Increased serum ferritin (HP:0003281)1.89507931
110Abnormalities of placenta or umbilical cord (HP:0001194)1.88931509
111Reduced subcutaneous adipose tissue (HP:0003758)1.88722777
112Squamous cell carcinoma (HP:0002860)1.88721411
113Sparse lateral eyebrow (HP:0005338)1.88220764
114Back pain (HP:0003418)1.87328565
115Secondary amenorrhea (HP:0000869)1.86247294
116Elbow flexion contracture (HP:0002987)1.84360738
117Muscle fibrillation (HP:0010546)1.83941010
118Biconcave vertebral bodies (HP:0004586)1.82786050
119Abnormality of chromosome stability (HP:0003220)1.82115498
120* Absent forearm bone (HP:0003953)1.81418074
121* Aplasia involving forearm bones (HP:0009822)1.81418074
122Adenoma sebaceum (HP:0009720)1.80973001
123Angiofibromas (HP:0010615)1.80973001
124Orthostatic hypotension (HP:0001278)1.80681661
125Renal duplication (HP:0000075)1.80648496
126Facial hemangioma (HP:0000329)1.80275507
127Short nail (HP:0001799)1.79021195
128Patellar dislocation (HP:0002999)1.78977972
129Cellular immunodeficiency (HP:0005374)1.78799575
130Abnormality of the astrocytes (HP:0100707)1.78666601
131Astrocytoma (HP:0009592)1.78666601
132Impulsivity (HP:0100710)1.78528236
133Spinal cord lesions (HP:0100561)1.78299306
134Syringomyelia (HP:0003396)1.78299306
135Short 4th metacarpal (HP:0010044)1.78259562
136Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78259562
137Ectopic kidney (HP:0000086)1.78076271
138Optic nerve coloboma (HP:0000588)1.77469631
139Overriding aorta (HP:0002623)1.76228467
140Progressive external ophthalmoplegia (HP:0000590)1.75115970
141Entropion (HP:0000621)1.74177198
142Poor head control (HP:0002421)1.73744000
143Muscle fiber atrophy (HP:0100295)1.72765051
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.72710848
145Breech presentation (HP:0001623)1.71658139
146Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71541439
147Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71541439
148Asymmetry of the thorax (HP:0001555)1.71509498
149Genu recurvatum (HP:0002816)1.70290938
150Abnormal neuron morphology (HP:0012757)1.69643001
151Abnormality of the motor neurons (HP:0002450)1.69643001
152Flat acetabular roof (HP:0003180)1.69554150
153Abnormality of the duodenum (HP:0002246)1.69091426
154Lymphoma (HP:0002665)1.68977964
155Progressive hearing impairment (HP:0001730)1.68712262
156Abnormality of the calcaneus (HP:0008364)1.68205160
157Personality changes (HP:0000751)1.67755084
158Increased connective tissue (HP:0009025)1.67708759
159Increased IgM level (HP:0003496)1.66800349
160Spastic paraparesis (HP:0002313)1.66580806
161Abnormality of the umbilical cord (HP:0010881)1.65897437
162Cellulitis (HP:0100658)1.64977932
163Abnormality of the thoracic spine (HP:0100711)1.61998814
164Disproportionate tall stature (HP:0001519)1.59816861
165Prolonged neonatal jaundice (HP:0006579)1.59022147
166Loss of speech (HP:0002371)1.56196944
167Progressive neurologic deterioration (HP:0002344)1.55950700
168Natal tooth (HP:0000695)1.55410495
169Abnormality of glycolipid metabolism (HP:0010969)1.54426518
170Abnormality of liposaccharide metabolism (HP:0010968)1.54426518
171Abnormality of glycosphingolipid metabolism (HP:0004343)1.54426518
172Pseudobulbar signs (HP:0002200)1.53910861
173Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53655760
174Upper limb muscle weakness (HP:0003484)1.52507142
175Dysautonomia (HP:0002459)1.52500779
176Upper motor neuron abnormality (HP:0002127)1.51343837
177Increased cerebral lipofuscin (HP:0011813)1.51274156
178Poikiloderma (HP:0001029)1.51271272
179Seborrheic dermatitis (HP:0001051)1.51100547
180Type I transferrin isoform profile (HP:0003642)1.51020901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.72963766
2SMG13.64596942
3TESK23.60595737
4WEE13.28947805
5EIF2AK13.20208712
6CDC73.19826708
7VRK23.13227429
8IRAK32.55155679
9NME22.43519817
10SIK12.42991556
11NEK22.29390787
12PRPF4B2.20742193
13MAP3K102.16109102
14CDK122.12801890
15TSSK61.94798441
16RPS6KA41.93835077
17CDK71.93438055
18TESK11.93028218
19MAP3K111.84160440
20DYRK31.76851109
21TTK1.74809397
22SIK31.70502006
23PLK11.64301886
24SRPK11.63376500
25RPS6KB21.62085822
26KDR1.60572628
27EEF2K1.59925869
28PAK41.59729348
29PIM21.59198635
30STK101.56537255
31EPHA21.51299000
32MAP4K11.50898958
33SCYL21.45021110
34NEK11.42481773
35MAP3K81.37609038
36TLK11.33614986
37PASK1.31964676
38AURKA1.31202506
39ATR1.30176688
40PLK41.28962593
41AURKB1.28230177
42TRIB31.27385493
43CDK41.22495827
44ACVR1B1.20842159
45CHEK21.18070902
46BRSK21.17087096
47PKN21.13535777
48STK161.11796833
49ERN11.11769039
50EIF2AK31.09242042
51LIMK11.08261626
52MKNK11.06129225
53VRK11.02887914
54CHEK11.02348987
55ARAF1.01762497
56MST1R1.00271108
57ALK0.97524155
58LATS20.94446803
59BCKDK0.92981934
60BRSK10.91512522
61TGFBR10.90682435
62PAK10.90005249
63PBK0.86392111
64TBK10.85522555
65PLK30.84303666
66PIM10.83525046
67LRRK20.83522783
68CDK90.82571991
69STK40.79489671
70MAPKAPK30.79079483
71FGFR40.78845363
72BLK0.78320646
73ZAP700.77693802
74CDK20.77647678
75ICK0.76688023
76EPHB10.76536127
77DAPK10.74636318
78PTK20.74486031
79MKNK20.74130242
80BRD40.74033769
81TAOK20.72493954
82PRKD20.71933793
83GRK60.70698373
84CDK60.70289243
85IRAK40.70136249
86PTK60.67639795
87TAF10.66593440
88CDK80.66257027
89MTOR0.62917867
90MAP3K140.61775917
91TAOK10.60455520
92DYRK1B0.60372158
93CSNK2A20.60152442
94ATM0.58735482
95MAP2K30.56682218
96PRKCI0.56546316
97FLT30.56456970
98NME10.56181924
99CSNK2A10.56176442
100MAP3K10.54467669
101AKT20.53404924
102DYRK20.49785630
103PRKG20.47596216
104TTN0.47231582
105PRKD30.47138107
106CLK10.46713382
107CDK10.46497632
108ILK0.44009314
109BMX0.43684808
110PAK20.41260507
111BTK0.40646271
112MAPKAPK20.40549549
113CDK11A0.40435250
114HIPK20.39803035
115PDGFRA0.39126049
116LMTK20.39027649
117CCNB10.37604974
118RIPK10.37387638
119ABL20.36017555
120KSR20.35872555
121CSF1R0.35409554
122IKBKB0.34639309
123MAP2K20.34183490
124MELK0.33662888
125CDK140.32709719
126RPS6KA10.32183760
127RPS6KA50.31536002
128MAP3K30.31023556
129RPS6KA60.30837123
130RPS6KC10.30592458
131RPS6KL10.30592458
132FGFR10.29127792
133MAPK110.28207652
134BRAF0.27845818
135CSNK1E0.27808774
136MATK0.27482212

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83105322
2Mismatch repair_Homo sapiens_hsa034304.00982413
3Ribosome_Homo sapiens_hsa030103.58872918
4* Spliceosome_Homo sapiens_hsa030403.44463454
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42511739
6Base excision repair_Homo sapiens_hsa034103.11377855
7RNA transport_Homo sapiens_hsa030133.04579182
8Proteasome_Homo sapiens_hsa030503.03640479
9RNA polymerase_Homo sapiens_hsa030202.83262858
10Nucleotide excision repair_Homo sapiens_hsa034202.67119583
11Cell cycle_Homo sapiens_hsa041102.59678828
12One carbon pool by folate_Homo sapiens_hsa006702.59212566
13Homologous recombination_Homo sapiens_hsa034402.53210404
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31824506
15Pyrimidine metabolism_Homo sapiens_hsa002402.24669097
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84534016
17mRNA surveillance pathway_Homo sapiens_hsa030151.82385713
18p53 signaling pathway_Homo sapiens_hsa041151.71748315
19Fanconi anemia pathway_Homo sapiens_hsa034601.67811086
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62415767
21RNA degradation_Homo sapiens_hsa030181.58364033
22Basal transcription factors_Homo sapiens_hsa030221.56708239
23Non-homologous end-joining_Homo sapiens_hsa034501.44775237
24Epstein-Barr virus infection_Homo sapiens_hsa051691.31418405
25Other glycan degradation_Homo sapiens_hsa005111.28831818
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07563165
27Antigen processing and presentation_Homo sapiens_hsa046121.06587843
28Herpes simplex infection_Homo sapiens_hsa051681.03869062
29Sulfur relay system_Homo sapiens_hsa041221.03834443
30Vibrio cholerae infection_Homo sapiens_hsa051101.02987826
31HTLV-I infection_Homo sapiens_hsa051661.01633713
32Purine metabolism_Homo sapiens_hsa002300.99700841
33Cyanoamino acid metabolism_Homo sapiens_hsa004600.98188255
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97464769
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96588178
36Viral carcinogenesis_Homo sapiens_hsa052030.95937831
37Thyroid cancer_Homo sapiens_hsa052160.93912223
38Shigellosis_Homo sapiens_hsa051310.87637929
39Fatty acid elongation_Homo sapiens_hsa000620.87506356
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83415569
41Oocyte meiosis_Homo sapiens_hsa041140.83343443
42Biosynthesis of amino acids_Homo sapiens_hsa012300.82865884
43Folate biosynthesis_Homo sapiens_hsa007900.81810036
44Bladder cancer_Homo sapiens_hsa052190.81142660
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80659369
46Legionellosis_Homo sapiens_hsa051340.79799840
47Primary immunodeficiency_Homo sapiens_hsa053400.76868120
48Notch signaling pathway_Homo sapiens_hsa043300.75649238
49Pentose phosphate pathway_Homo sapiens_hsa000300.75138615
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74977333
51Hepatitis C_Homo sapiens_hsa051600.73468475
52Hippo signaling pathway_Homo sapiens_hsa043900.73068423
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.72947273
54MicroRNAs in cancer_Homo sapiens_hsa052060.71648244
55Chronic myeloid leukemia_Homo sapiens_hsa052200.71141076
56Basal cell carcinoma_Homo sapiens_hsa052170.70521037
57Endometrial cancer_Homo sapiens_hsa052130.69207517
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69074438
59Small cell lung cancer_Homo sapiens_hsa052220.69011409
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.68188924
61Prion diseases_Homo sapiens_hsa050200.67834940
62Acute myeloid leukemia_Homo sapiens_hsa052210.67572662
63Apoptosis_Homo sapiens_hsa042100.67266158
64Selenocompound metabolism_Homo sapiens_hsa004500.65656084
65Salmonella infection_Homo sapiens_hsa051320.63946447
66Colorectal cancer_Homo sapiens_hsa052100.62103659
67Lysosome_Homo sapiens_hsa041420.61639636
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61058986
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60277486
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58879569
71Hepatitis B_Homo sapiens_hsa051610.58698229
72TGF-beta signaling pathway_Homo sapiens_hsa043500.57697087
73Measles_Homo sapiens_hsa051620.57533652
74Endocytosis_Homo sapiens_hsa041440.54319582
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53890998
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53587875
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52979692
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51429788
79Systemic lupus erythematosus_Homo sapiens_hsa053220.49178329
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.48847839
81Hedgehog signaling pathway_Homo sapiens_hsa043400.47585954
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.46220491
83TNF signaling pathway_Homo sapiens_hsa046680.46021428
84Osteoclast differentiation_Homo sapiens_hsa043800.44942670
85Viral myocarditis_Homo sapiens_hsa054160.44719760
86HIF-1 signaling pathway_Homo sapiens_hsa040660.43104321
87Adherens junction_Homo sapiens_hsa045200.42423557
88Renal cell carcinoma_Homo sapiens_hsa052110.40392015
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39469290
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.39236889
91Protein export_Homo sapiens_hsa030600.39095063
92Pathways in cancer_Homo sapiens_hsa052000.37852254
93N-Glycan biosynthesis_Homo sapiens_hsa005100.37364395
94Glutathione metabolism_Homo sapiens_hsa004800.37203207
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36466593
96Fructose and mannose metabolism_Homo sapiens_hsa000510.35767628
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35747931
98Leishmaniasis_Homo sapiens_hsa051400.34191858
99mTOR signaling pathway_Homo sapiens_hsa041500.34144093
100Influenza A_Homo sapiens_hsa051640.33039069
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32984880
102AMPK signaling pathway_Homo sapiens_hsa041520.32801648
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31851054
104Toxoplasmosis_Homo sapiens_hsa051450.31697069
105Carbon metabolism_Homo sapiens_hsa012000.31302698
106Galactose metabolism_Homo sapiens_hsa000520.29755294
107Proteoglycans in cancer_Homo sapiens_hsa052050.28656952
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28298394
109T cell receptor signaling pathway_Homo sapiens_hsa046600.27495582
110Wnt signaling pathway_Homo sapiens_hsa043100.27422138
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27373816
112Hematopoietic cell lineage_Homo sapiens_hsa046400.26475274
113B cell receptor signaling pathway_Homo sapiens_hsa046620.26365238
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26270356
115Vitamin B6 metabolism_Homo sapiens_hsa007500.26194671
116Pancreatic cancer_Homo sapiens_hsa052120.26119543
117Non-small cell lung cancer_Homo sapiens_hsa052230.25069661
118Prostate cancer_Homo sapiens_hsa052150.24408137
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.24034566
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22284318
121Huntingtons disease_Homo sapiens_hsa050160.22213072
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.20540989
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20321741
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19797702
125VEGF signaling pathway_Homo sapiens_hsa043700.19611617

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »